Use of NAC in Alleviation of Hangover Symptoms
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ClinicalTrials.gov Identifier: NCT02541422 |
Recruitment Status :
Completed
First Posted : September 4, 2015
Results First Posted : May 30, 2018
Last Update Posted : May 30, 2018
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Hangover Symptoms, NAC | Dietary Supplement: N Acetyl Cysteine Other: placebo | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 62 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) |
Primary Purpose: | Prevention |
Official Title: | Use of NAC in Alleviation of Hangover Symptoms |
Study Start Date : | August 2015 |
Actual Primary Completion Date : | December 2015 |
Actual Study Completion Date : | December 2015 |

Arm | Intervention/treatment |
---|---|
Active Comparator: NAC group
Patients receiving NAC after drinking to breathalyzer value 0.1
|
Dietary Supplement: N Acetyl Cysteine
Other Name: NAC |
Placebo Comparator: Placebo group
Patients receiving placebo after drinking to breathalyzer value 0.1
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Other: placebo |
- Hangover Symptom Scale [ Time Frame: 12 hours or less ]In the morning, each participate will fill out a Hangover Symptom Score questionnaire, evaluating each hangover symptom on a 0 - 4 point Hangover Symptom Severity scale. 0 representing "strongly disagree" or "feels like I did not drink last night" to 4 representing "strongly agree" or "I'm so hungover / I'm never drinking again" for each symptom. The symptoms on the Hangover Symptom Scale are: feeling thirsty or dehydrated, feeling more tired than usual, headache, nauseated, vomited, feeling weak, difficulty concentrating, more sensitive to light and sound than usual, sweating more than usual, had trouble sleeping, feeling anxious, feeling depressed, experienced trembling or shaking. The total score could range from 0-52 with 0 being no symptoms of hangover and 52 being the worst symptoms of hangover. This study looked specifically at the overall hangover score, nauseated, feeling weak and headache.

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Ages Eligible for Study: | 21 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- healthy volunteers over age 21 years
Exclusion Criteria:
- Volunteers will be excluded from the study if they suffer from any of the following conditions:
- Alcoholism,
- Pregnancy,
- Reactive Airway Disease,
- Diabetes,
- Kidney or bladder stones,
- Kidney disease,
- Liver disease,
- Stomach ulcer,
- Organ transplant patients,
- Dialysis patients,
- and patients with alcohol, egg, milk or wheat allergies.
Volunteers taking the following medications will not be able to participate:
- activated charcoal,
- ampicillin,
- carbamazepine,
- cephaloridine,
- cloxacillin,
- methicillin,
- nitroglycerine,
- oxacillin,
- penicillin G,
- or quinacillin.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02541422
United States, Pennsylvania | |
St. Luke's Hospital | |
Bethlehem, Pennsylvania, United States, 18015 |
Principal Investigator: | Holly A Stankewicz, D.O. | St. Luke's Hospital and Health Network, Pennsylvania |
Responsible Party: | Holly Stankewicz, D.O., Attending physician and faculty emergency medicine residency, St. Luke's Hospital and Health Network, Pennsylvania |
ClinicalTrials.gov Identifier: | NCT02541422 |
Other Study ID Numbers: |
SLHN 2015-27 |
First Posted: | September 4, 2015 Key Record Dates |
Results First Posted: | May 30, 2018 |
Last Update Posted: | May 30, 2018 |
Last Verified: | September 2017 |
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