An Efficacy and Safety Study of JNJ-56021927 (Apalutamide) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy: ATLAS
|
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. |
| ClinicalTrials.gov Identifier: NCT02531516 |
|
Recruitment Status
:
Recruiting
First Posted
: August 24, 2015
Last Update Posted
: April 6, 2018
|
Sponsor:
Aragon Pharmaceuticals, Inc.
Information provided by (Responsible Party):
Aragon Pharmaceuticals, Inc.
- Study Details
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- No Results Posted
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Brief Summary:
The purpose of this study is to determine if apalutamide plus gonadotropin releasing hormone (GnRH) agonist in participants with high-risk, localized or locally advanced prostate cancer receiving primary radiation therapy results in an improvement of metastasis-free survival.
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Prostatic Neoplasms | Drug: Apalutamide Drug: Bicalutamide Drug: Bicalutamide Placebo Drug: Apalutamide Placebo Drug: GnRH (agonist) Radiation: 74-80 Grays (units of radiation) | Phase 3 |
This is a randomized, double-blind, placebo-controlled, multicenter study of apalutamide plus GnRH agonist compared with GnRH agonist among participants with high-risk, localized or locally advanced prostate cancer receiving primary radiation therapy (RT). The study will include a Screening Phase, Treatment Phase, a Posttreatment Phase, and a Long-term Follow-up Phase. Participants will either receive either apalutamide (experimental) or bicalutamide 50 milligram (mg) capsule plus placebo as control group. Safety will be monitored throughout the study.
| Study Type : | Interventional (Clinical Trial) |
| Estimated Enrollment : | 1500 participants |
| Allocation: | Randomized |
| Intervention Model: | Parallel Assignment |
| Masking: | Double (Participant, Investigator) |
| Primary Purpose: | Treatment |
| Official Title: | ATLAS: A Randomized, Double-blind, Placebo-controlled Phase 3 Study of JNJ-56021927 in Subjects With High-risk, Localized or Locally Advanced Prostate Cancer Receiving Treatment With Primary Radiation Therapy |
| Actual Study Start Date : | November 19, 2015 |
| Estimated Primary Completion Date : | December 30, 2022 |
| Estimated Study Completion Date : | October 6, 2026 |
Resource links provided by the National Library of Medicine
Genetics Home Reference related topics:
Prostate cancer
MedlinePlus related topics:
Prostate Cancer
U.S. FDA Resources
| Arm | Intervention/treatment |
|---|---|
|
Experimental: Apalutamide
Participants will receive apalutamide (240 mg), by mouth, once daily for overall 30 months, plus bicalutamide placebo, by mouth, once daily, for four months from randomization. All participants are treated with gonadotropin releasing hormone (GnRH) agonist for 30 months from randomization and radiation therapy to the prostate started at about 8 weeks after randomization.
|
Drug: Apalutamide Drug: Bicalutamide Placebo Drug: GnRH (agonist) Radiation: 74-80 Grays (units of radiation) |
|
Active Comparator: Control group
Participants will receive apalutamide placebo, by mouth, once daily for overall 30 months, plus bicalutamide (50 mg), by mouth, once daily, for four months from randomization. All participants are treated with gonadotropin releasing hormone (GnRH) agonist for 30 months from randomization and radiation therapy to the prostate started at about 8 weeks after randomization.
|
Drug: Bicalutamide Drug: Apalutamide Placebo Drug: GnRH (agonist) Radiation: 74-80 Grays (units of radiation) |
Primary Outcome Measures
:
- Metastasis-free survival [ Time Frame: 84 Months ]
Secondary Outcome Measures
:
- Time to Local-regional Recurrence [ Time Frame: 84 Months ]
- Time to Castration-resistant Prostate Cancer (CRPC) [ Time Frame: 84 Months ]
- Time to Distant Metastasis [ Time Frame: 84 Months ]
- Overall Survival (OS) [ Time Frame: 84 Months ]
Information from the National Library of Medicine
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
| Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
| Sexes Eligible for Study: | Male |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Age >= 18 years
- Indicated and planned to receive primary radiation therapy for prostate cancer
- Histologically confirmed adenocarcinoma of an intact prostate, and 1 of the following at diagnosis: 1) Gleason score >=8 and >=cT2c, 2) Gleason score >=7, PSA >=20 nanogram per milliliters (ng/mL), and >=cT2c
- Charlson index (CCI) <=3
- An Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) grade of 0 or 1
- Adequate organ function: (1) aspartate aminotransferase (AST), alanine aminotransferase (ALT), within normal limits (WNL), (2) serum creatinine less than (<) 1.5 milligram/deciliter (mg/dL) (<133 micromoles/Liter [mcmol/L]), (3) platelets greater than or equal to (>=)140,000/microLiter (mcL), independent of transfusion and/or growth factors within 3 months prior to randomization, (4) Hemoglobin >= 12.0 gram/deciliter (g/dL) (7.4 millimloes [mmol], independent of transfusion and/or growth factors within 3 months prior to randomization
- Participants who are sexually active (even men with vasectomies) and willing to use a condom and agree not to donate sperm during the trial
- Signed, written, informed consent
- Be able to swallow whole study drug tablets
Exclusion Criteria: -
- Presence of distant metastasis, (clinical stage M1). Isolated pelvic nodal disease below the iliac bifurcation (clinical stage N1) is not an exclusion. Diagnosis of distant metastasis (clinical M stage; M0 versus M1a, M1b, M1c) and pelvic nodal disease (clinical N stage; N1 versus N0) will be assessed by central radiological review. Patients are considered eligible only if the central radiological review confirms clinical stage M0.
- Prior treatment with gonadotropin releasing hormone (GnRH) analogue or anti-androgen or both for >3 months prior to randomization
- Bilateral orchiectomy
- History of pelvic radiation
- Prior systemic (example [e.g.], chemotherapy) or local (e.g. radical prostatectomy, cryotherapy) treatment for prostate cancer
- History of seizure or any condition that may predispose to seizure (including, but not limited to prior stroke, transient ischemic attack or loss of consciousness <= 1 year prior to randomization; brain arteriovenous malformation; or intracranial masses such as schwannomas and meningiomas that are causing edema or mass effect)
- Prior treatment with enzalutamide, abiraterone acetate, orteronel, galeterone, ketoconazole, aminoglutethimide, estrogens, megestrol acetate, and progestational agents (including cyproterone acetate) for prostate cancer
- Prior treatment with radiopharmaceutical agents (e.g., strontium-89) or immunotherapy (e.g., sipuleucel-T) for prostate cancer
- Prior treatment with systemic glucocorticoids ≤4 weeks prior to randomization or is expected to require long-term use of corticosteroids during the study
- Use of 5-alpha reductase inhibitors (e.g., dutasteride, finasteride) <=4 weeks prior to randomization
- Use of any investigational agent <=4 weeks prior to randomization
- Current chronic use of opioid analgesics for >=3 weeks for oral or >7 days for non-oral formulations
- Major surgery <=4 weeks prior to randomization
- Current or prior treatment with anti-epileptic medications for the treatment of seizures
- Gastrointestinal conditions affecting absorption
- Known or suspected contraindications or hypersensitivity to apalutamide, bicalutamide or GnRH agonists or any of the components of the formulations
- Any condition for which, in the opinion of the investigator, participation would not be in the best interest of the subject
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02531516
Contacts
| Contact: Use link at the bottom of the page to see if you qualify for an enrolling site (see list). If you still have questions: | JNJ.CT@sylogent.com |
Hide Study Locations
Locations
| United States, Alabama | |
| Urology Centers Of Alabama | Completed |
| Homewood, Alabama, United States, 35209 | |
| United States, Arizona | |
| Ironwood Cancer and Research Center | Recruiting |
| Chandler, Arizona, United States, 85224 | |
| 21st Century Oncology | Completed |
| Scottsdale, Arizona, United States, 85251 | |
| Arizona Institute of Urology | Completed |
| Tucson, Arizona, United States, 85704 | |
| El Dorado Urology & Prostate Center | Withdrawn |
| Tucson, Arizona, United States, 85715 | |
| Urological Associates of Southern Arizona, P.C. | Recruiting |
| Tucson, Arizona, United States, 85741 | |
| United States, California | |
| CBCC Global Research | Completed |
| Bakersfield, California, United States, 93309 | |
| Cedars-Sinai Medical Center | Recruiting |
| Los Angeles, California, United States, 90048 | |
| Tower Urology | Recruiting |
| Los Angeles, California, United States, 90048 | |
| VA West Los Angeles Medical Center | Completed |
| Los Angeles, California, United States, 90073 | |
| University of California, Irvine | Recruiting |
| Orange, California, United States, 92868 | |
| San Bernardino Urological Associates | Recruiting |
| San Bernardino, California, United States, 92404 | |
| Genesis Research | Completed |
| San Diego, California, United States, 92123 | |
| California Pacific Medical Center | Completed |
| San Francisco, California, United States, 94115 | |
| Department of Radiation Oncology UCSF | Not yet recruiting |
| San Francisco, California, United States, 98115 | |
| United States, Colorado | |
| University of Colorado | Recruiting |
| Aurora, Colorado, United States, 80045 | |
| The Urology Center of Colorado | Recruiting |
| Denver, Colorado, United States, 80211 | |
| United States, Connecticut | |
| CT Clinical Research Center | Recruiting |
| Middlebury, Connecticut, United States, 6762 | |
| United States, Florida | |
| Manatee Medical Research Center | Recruiting |
| Bradenton, Florida, United States, 34205 | |
| Atlantic Urology Associates | Recruiting |
| Daytona Beach, Florida, United States, 32114 | |
| 21st Century Oncology | Completed |
| Fort Myers, Florida, United States, 33908 | |
| Urology Specialists LLC | Recruiting |
| Hialeah, Florida, United States, 33002 | |
| 21st Century Oncology | Recruiting |
| Lakewood Ranch, Florida, United States, 34202 | |
| 21st Century Oncology | Recruiting |
| Naples, Florida, United States, 34102 | |
| 21st Century Oncology | Recruiting |
| Plantation, Florida, United States, 33324 | |
| United States, Idaho | |
| Saint Alphonsus Regional Medical Center- Cancer Care Center | Withdrawn |
| Boise, Idaho, United States, 83706 | |
| Idaho Urologic Institute | Recruiting |
| Meridian, Idaho, United States, 83642 | |
| United States, Illinois | |
| Research by Design, LLC | Completed |
| Evergreen Park, Illinois, United States, 60805 | |
| Monroe Medical Associates Ingalls | Recruiting |
| Harvey, Illinois, United States, 60426 | |
| United States, Indiana | |
| First Urology | Recruiting |
| Jeffersonville, Indiana, United States, 47130 | |
| United States, Kansas | |
| Wichita Urology Group | Recruiting |
| Wichita, Kansas, United States, 67226 | |
| United States, Kentucky | |
| Ashland-Bellfonte Cancer Center | Recruiting |
| Ashland, Kentucky, United States, 41101 | |
| University of Kentucky Medical Center | Withdrawn |
| Lexington, Kentucky, United States, 40536 | |
| United States, Louisiana | |
| Tulane University, Office of Clinical Research | Recruiting |
| New Orleans, Louisiana, United States, 70112 | |
| Regional Urology | Recruiting |
| Shreveport, Louisiana, United States, 71106 | |
| United States, Maine | |
| New England Cancer Specialists | Completed |
| Scarborough, Maine, United States, 4074 | |
| United States, Maryland | |
| University of Maryland | Recruiting |
| Baltimore, Maryland, United States, 21201 | |
| Chesapeake Urology Research Associates | Recruiting |
| Owings Mills, Maryland, United States, 21117 | |
| United States, Massachusetts | |
| Massachusetts General | Recruiting |
| Boston, Massachusetts, United States, 2114 | |
| United States, Michigan | |
| 21st Century Oncology | Withdrawn |
| Farmington Hills, Michigan, United States, 48334 | |
| United States, Missouri | |
| Washington University of St Louis- Alvin J Siteman Cancer Center | Recruiting |
| Saint Louis, Missouri, United States, 63110 | |
| United States, New Jersey | |
| Morristown Medical Center | Recruiting |
| Morristown, New Jersey, United States, 7960 | |
| United States, New York | |
| The Urological Institute of Northeastern New York | Recruiting |
| Albany, New York, United States, 12208 | |
| Montefiore Medical Center | Recruiting |
| Bronx, New York, United States, 10461 | |
| Brooklyn Urology Research Group | Recruiting |
| Brooklyn, New York, United States, 11201 | |
| AccuMed Research Associates | Withdrawn |
| Garden City, New York, United States, 11530 | |
| NYU University Urology | Completed |
| New York, New York, United States, 100016 | |
| Premier Medical Group | Recruiting |
| Poughkeepsie, New York, United States, 12601 | |
| University of Rochester Medical Center | Recruiting |
| Rochester, New York, United States, 14642 | |
| Associated Medical Professionals | Recruiting |
| Syracuse, New York, United States, 13210 | |
| United States, North Carolina | |
| Cary Urology PA | Completed |
| Cary, North Carolina, United States, 27511 | |
| University of North Carolina | Withdrawn |
| Chapel Hill, North Carolina, United States, 27599 | |
| Alliance Urology Specialists | Withdrawn |
| Greensboro, North Carolina, United States, 27403 | |
| Associated Urologists of North Carolina | Completed |
| Raleigh, North Carolina, United States, 27612 | |
| Coastal Carolina Radiation Oncology | Withdrawn |
| Wilmington, North Carolina, United States, 28401 | |
| United States, Ohio | |
| TriState Urologic Services PSC Inc. DBA The Urology Group | Withdrawn |
| Cincinnati, Ohio, United States, 45212 | |
| University Hospitals Case Medical Center | Withdrawn |
| Cleveland, Ohio, United States, 44106 | |
| Signal Point Hematology Oncology | Withdrawn |
| Middletown, Ohio, United States, 45042 | |
| United States, Oregon | |
| Oregon Health & Science University | Recruiting |
| Portland, Oregon, United States, 97239-3098 | |
| Oregon Urology Institute | Recruiting |
| Springfield, Oregon, United States, 97477 | |
| United States, Pennsylvania | |
| Urologic Consultants of SE PA | Recruiting |
| Bala-Cynwyd, Pennsylvania, United States, 19004 | |
| Urology Health Specialists, LLC | Recruiting |
| Bryn Mawr, Pennsylvania, United States, 19010 | |
| Lancaster Urology | Recruiting |
| Lancaster, Pennsylvania, United States, 17604 | |
| Thomas Jefferson University | Recruiting |
| Philadelphia, Pennsylvania, United States, 19107 | |
| United States, Rhode Island | |
| Omega Medical Research | Recruiting |
| Warwick, Rhode Island, United States, 02886 | |
| United States, South Carolina | |
| Charleston Hematology Oncology | Completed |
| Charleston, South Carolina, United States, 29414 | |
| Carolina Urologic Research Center | Recruiting |
| Myrtle Beach, South Carolina, United States, 29572 | |
| United States, Tennessee | |
| Urology Associates | Recruiting |
| Nashville, Tennessee, United States, 37209 | |
| Vanderbilt University | Withdrawn |
| Nashville, Tennessee, United States, 37235 | |
| United States, Texas | |
| Urology Clinics of North Texas | Completed |
| Dallas, Texas, United States, 75231 | |
| Texas Oncology P.A. | Completed |
| Houston, Texas, United States, 77024 | |
| Houston Metro Urology | Recruiting |
| Houston, Texas, United States, 77027 | |
| Houston Methodist Cancer Center | Recruiting |
| Houston, Texas, United States, 77030 | |
| Urology San Antonio Research | Completed |
| San Antonio, Texas, United States, 78229 | |
| United States, Virginia | |
| INOVA Dwiight &Martha Schar Cancer Institute | Recruiting |
| Fairfax, Virginia, United States, 22031 | |
| Sentara Rockingham Memorial Hospital Hahn Cancer Center | Withdrawn |
| Harrisonburg, Virginia, United States, 22801 | |
| Urology of Virginia, PLCC | Recruiting |
| Virginia Beach, Virginia, United States, 23462 | |
| United States, Washington | |
| Seattle Urology Research Center | Recruiting |
| Burien, Washington, United States, 98166 | |
| Medical Oncology Associates, PS | Completed |
| Spokane, Washington, United States, 99208-1129 | |
| United States, West Virginia | |
| West Virginia University Medical Center | Completed |
| Morgantown, West Virginia, United States, 26506 | |
| Argentina | |
| Fundación Investigar | Recruiting |
| C.a.b.a., Argentina, C1025ABI | |
| Instituto Medico Alexander Fleming | Recruiting |
| C.a.b.a., Argentina, C1426ANZ | |
| Hospital Militar Cosme Argerich | Recruiting |
| C.a.b.a., Argentina, C1426BOR | |
| Centro de Urologia (CDU) | Recruiting |
| Caba, Argentina, C1120AAT | |
| Fundacion Favaloro | Not yet recruiting |
| Ciudad Autonoma De Buenos Aires, Argentina, C1093AAS | |
| Centro de Investigacion Pergamino SA | Recruiting |
| Pergamino, Argentina, B2700CPM | |
| Sanatorio Britanico de Rosario | Recruiting |
| Rosario, Argentina, 2000 | |
| Instituto de Oncologia de Rosario (IOR) | Recruiting |
| Rosario, Argentina, S2000KZE | |
| ARS Médica | Recruiting |
| San Salvador De Jujuy, Argentina, Y4600AFW | |
| Clínica Viedma | Withdrawn |
| Viedma, Argentina, R8500ACE | |
| Belgium | |
| OLV Ziekenhuis Aalst | Recruiting |
| Aalst, Belgium, 9300 | |
| Imelda Bonheiden | Completed |
| Bonheiden, Belgium, 2820 | |
| UCL St Luc | Recruiting |
| Brussel, Belgium, B-1200 | |
| Jolimont | Recruiting |
| Haine-St-Paul, Belgium, 7100 | |
| UZ Leuven | Recruiting |
| Leuven, Belgium, 3000 | |
| Sart Tilman | Recruiting |
| Liège, Belgium, 4000 | |
| Clinique et Maternité Sainte Elisabeth | Completed |
| Namur, Belgium, 5000 | |
| Algemeen Ziekenhuis Delta | Recruiting |
| Roeselare, Belgium, 8800 | |
| AZ Nikolaas | Completed |
| Sint-Niklaas, Belgium, 9100 | |
| AZ Turnhout | Recruiting |
| Turnhout, Belgium, 2300 | |
| GZA Ziekenhuis | Recruiting |
| Wilrijk, Belgium, 2610 | |
| Brazil | |
| Fundacao Pio Xii - Hospital De Cancer De Barretos | Recruiting |
| Barretos, Brazil, 14784-400 | |
| Cetus Oncologia | Recruiting |
| Belo Horizonte, Brazil, 30150-270 | |
| Instituto Mario Penna | Recruiting |
| Belo Horizonte, Brazil, 30380-472 | |
| Instituto do Radium de Campinas Ltda. | Recruiting |
| Campinas, Brazil, 13075-460 | |
| Hospital Erasto Gaertner | Recruiting |
| Curitiba, Brazil, 81520-060 | |
| Centro de Pesquisas Oncológicas - CEPON | Recruiting |
| Florianópolis, Brazil, 88034-000 | |
| Hospital Araújo Jorge da Associação de Combate ao Câncer em Goiás | Recruiting |
| Goiânia, Brazil, 74605-070 | |
| Hospital de Caridade de Ijui - CACON | Recruiting |
| Ijui, Brazil, 98700-000 | |
| Liga Norte Riograndense Contra O Cancer | Recruiting |
| Natal, Brazil, 59075-740 | |
| Irmandade Santa Casa de Misericordia de Porto Alegre | Recruiting |
| Porto Alegre, Brazil, 90020-090 | |
| IRPCC - Instituto Ribeiraopretano de Combate ao Cancer | Recruiting |
| Ribeirao Preto, Brazil, 14015-130 | |
| Instituto Nacional do Cancer - INCA | Recruiting |
| Rio De Janeiro, Brazil, 20231-050 | |
| Hospital Universitário Pedro Ernesto | Recruiting |
| Rio De Janeiro, Brazil, 20551-030 | |
| Instituto COI de Pesquisa, Educação e Gestão | Recruiting |
| Rio De Janeiro, Brazil, 22793-080 | |
| Hospital Santa Isabel | Recruiting |
| Salvador, Brazil, 40050-410 | |
| Núcleo de Oncologia da Bahia | Recruiting |
| Salvador, Brazil, 42700-000 | |
| CEPHO - Centro de Estudos e Pesquisa de Hematologia e Oncologia | Recruiting |
| Santo André, Brazil, 09060-650 | |
| Fundacao Faculdade Regional De Medicina De Sao Jose Do Rio Preto | Recruiting |
| Sao Jose Do Rio Preto, Brazil, 15090-000 | |
| Centro de Pesquisa do Instituto do Cancer Arnaldo Vieira de Carvalho | Recruiting |
| Sao Paulo, Brazil, 01221-020 | |
| Santa Casa de Misericordia de São Paulo | Recruiting |
| Sao Paulo, Brazil, 01221-020 | |
| IBCC Instituto Brasileiro de Controle do Cancer | Recruiting |
| Sao Paulo, Brazil, 03102-002 | |
| Hospital Santa Marcelina | Recruiting |
| Sao Paulo, Brazil, 08270-070 | |
| Centro de Estudos e Pesquisas Oncologicas de Sorocaba (Instituto de Oncologia de Sorocaba) | Recruiting |
| Sorocaba, Brazil, 18030-075 | |
| Sociedade Hospital Samaritano | Recruiting |
| São Paulo, Brazil, 01232-010 | |
| Instituto de Estudo e Pesquisa Sao Lucas | Recruiting |
| São Paulo, Brazil, 01236-030 | |
| ICESP - Instituto do Câncer do Estado de São Paulo | Recruiting |
| São Paulo, Brazil, 01246-000 | |
| Hospital Sirio Libanes | Recruiting |
| São Paulo, Brazil, 01308-050 | |
| Fundação Antônio Prudente - A.C. Camargo Cancer Center | Recruiting |
| São Paulo, Brazil, 01509-900 | |
| Instituto de Assistência Médica ao Servidor Público Estadual - HSPE-FMO | Recruiting |
| São Paulo, Brazil, 04039-004 | |
| Hospital Israelita Albert Einstein | Recruiting |
| São Paulo, Brazil, 05651-900 | |
| Canada, Alberta | |
| Tom Baker Cancer Center, University of Calgary | Completed |
| Calgary, Alberta, Canada, T2N 4N2 | |
| Canada, British Columbia | |
| BC Cancer Agency, Fraser Valley Cancer Centre (FVCC) | Recruiting |
| Surrey, British Columbia, Canada, V3V 1Z2 | |
| British Columbia Cancer Agency (BCCA) - Vancouver Centre | Recruiting |
| Vancouver, British Columbia, Canada, V5Z 4E6 | |
| British Columbia Cancer Agency - Vancouver Island Centre | Recruiting |
| Victoria, British Columbia, Canada, V8R 6V5 | |
| Canada, Newfoundland and Labrador | |
| Doctor H. Bliss Murphy Cancer Centre | Withdrawn |
| St. John'S, Newfoundland and Labrador, Canada, A1B 3V6 | |
| Canada, Ontario | |
| Cancer Centre of Southeastern Ontario (Kingston Regional Cancer Centre) | Withdrawn |
| Kingston, Ontario, Canada, K7L 5P9 | |
| London Health Sciences Centre | Recruiting |
| London, Ontario, Canada, N6A 4L6 | |
| The Ottawa Hospital Cancer Centre | Recruiting |
| Ottawa, Ontario, Canada, K1H 8L6 | |
| Sunnybrook Health Sciences Center | Recruiting |
| Toronto, Ontario, Canada, M4N 3M5 | |
| Princess Margaret Cancer Centre | Recruiting |
| Toronto, Ontario, Canada, M5G 2M9 | |
| Canada, Quebec | |
| CISSS de l'Outaouais | Recruiting |
| Gatineau, Quebec, Canada, J8P 7H2 | |
| Hopital de la Cite de la Sante - Centre integre de cancerologie de Laval (CICL) | Recruiting |
| Laval, Quebec, Canada, H7M 3L9 | |
| McGill University - Jewish General Hospital | Recruiting |
| Montreal, Quebec, Canada, H3T 1E2 | |
| Hopital Maisonneuve-Rosemont | Recruiting |
| Montréal, Quebec, Canada, H1T 2M4 | |
| CHUM - Centre hospitalier universitaire de Montreal | Recruiting |
| Montréal, Quebec, Canada, H2X 3E4 | |
| Centre Hospitalier Universitaire de Sherbrooke | Recruiting |
| Sherbrooke, Quebec, Canada, J1H 5N4 | |
| Canada, Saskatchewan | |
| Allan Blair Cancer Centre, Paqua Hospital | Withdrawn |
| Regina, Saskatchewan, Canada, S4T 7T1 | |
| Saskatoon Cancer Centre at the University of Saskatchewan | Withdrawn |
| Saskatoon, Saskatchewan, Canada, S7N 4H4 | |
| Canada | |
| CHUQ - CHU de Quebec | Recruiting |
| Quebec, Canada, G1R 2J6 | |
| China | |
| Peking University First Hospital | Recruiting |
| Beijing, China, 100034 | |
| Beijing Friendship Hospital | Recruiting |
| Beijing, China, 100050 | |
| Peking University Third Hospital | Recruiting |
| Beijing, China, 100083 | |
| Beijing Cancer Hospital of Peking University | Recruiting |
| Beijing, China, 100142 | |
| Beijing Hospital | Recruiting |
| Beijing, China, 100730 | |
| Peking Union Medical College Hospital | Withdrawn |
| Beijing, China, 100730 | |
| Hunan Cancer hospital | Withdrawn |
| Changsha, China, 410013 | |
| The people's Hospital of Sichuan Province | Recruiting |
| Chengdu, China, 610072 | |
| Chongqing Cancer hospital | Recruiting |
| Chongqing, China, 400030 | |
| Sun Yat-Sen University Cancer Center | Withdrawn |
| Guangzhou, China, 430030 | |
| Guangzhou First Municipal People's Hospital | Recruiting |
| Guangzhou, China, 510180 | |
| The Second Affiliated Hospital of Zhejiang University | Recruiting |
| Hangzhou, China, 310009 | |
| Zhejiang Cancer Hospital | Recruiting |
| Hangzhou, China, 310015 | |
| The First Affliated Hospital Of Nanchang University | Recruiting |
| Nanchang, China, 330006 | |
| Jiangsu Cancer Hospital | Recruiting |
| Nanjing, China, 210000 | |
| Nanjing Drum Tower Hospital | Recruiting |
| Nanjing, China, 210008 | |
| Drug clinical trial ethics committee of Ningbo First Hospital | Recruiting |
| Ningbo, China, 315010 | |
| Fudan University Shanghai Cancer Center | Recruiting |
| Shanghai, China, 200032 | |
| Shanghai Zhongshan Hospital | Withdrawn |
| Shanghai, China, 200032 | |
| ShangHai Huadong Hospital | Recruiting |
| Shanghai, China, 200040 | |
| Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine | Recruiting |
| Shanghai, China, 200092 | |
| ShangHai Changhai Hospital | Withdrawn |
| Shanghai, China, 200433 | |
| Shanghai No. 1 Hospital | Recruiting |
| Shanghai, China, 201620 | |
| First Hospital of Shanxi Medical University | Withdrawn |
| Taiyuan, China, 030001 | |
| Wuhan Tongji Hospital, Tongji Medical College | Recruiting |
| Wuhan, China, 430030 | |
| First Affiliated Hospital, Xi'an Jiaotong University | Recruiting |
| Xi'An, China, 710004 | |
| Czechia | |
| Fakultní nemocnici Brno | Withdrawn |
| Brno, Czechia, 625 00 | |
| Fakultni nemocnice Hradec Kralove | Recruiting |
| Hradec Králove, Czechia, 500 05 | |
| Krajská nemocnice Liberec | Recruiting |
| Liberec, Czechia, 460 63 | |
| Nemocnice Novy Jicin a.s., oddeleni radioterapie a onkologie | Recruiting |
| Nový Jicin, Czechia, 741 01 | |
| Uromedical Center s.r.o. | Recruiting |
| Olomouc, Czechia, 77900 | |
| Slezska nemocnice v Opave | Recruiting |
| Opava, Czechia, 746 01 | |
| Onkologicke Centrum Multiscan | Recruiting |
| Pardubice, Czechia, 532 03 | |
| Fakultni nemocnice Kralovske Vinohrady | Recruiting |
| Praha 10, Czechia, 100 34 | |
| Urocentrum Praha | Recruiting |
| Praha 2, Czechia, 120 00 | |
| Urologicka klinika 1.LF UK a VFN | Recruiting |
| Praha 2, Czechia, 120 00 | |
| Thomayerova nemocnice | Recruiting |
| Praha 4, Czechia, 140 59 | |
| Urologicka klinika 2.LF UK a FN Motol | Recruiting |
| Praha 5, Czechia, 150 00 | |
| Nemocnice Na Bulovce | Recruiting |
| Praha 8, Czechia, 180 00 | |
| Krajska Nemocnice T. Bati a.s. (KNTB) - Ambulance Urologicka | Completed |
| Zlin, Czechia, 762 75 | |
| France | |
| Clinique de l'Europe | Recruiting |
| Amiens, France, 80090 | |
| Institut de Cancerologie de Ouest (ICO) Site Paul Papin | Completed |
| Angers Cedex 02, France, 49055 | |
| Institut Sainte Catherine | Recruiting |
| Avignon Cedex 9, France, 84918 | |
| Centre d'Oncologie et de Radiothérapie du Pays Basque | Recruiting |
| Bayonne, France, 64100 | |
| CHRU De Besancon | Recruiting |
| Besancon, France, 25030 | |
| Institut Bergonié | Recruiting |
| Bordeaux, France, 33000 | |
| CHU Brest | Recruiting |
| Brest, France, 29200 | |
| Centre d'oncologie et de radiothérapie du Parc | Recruiting |
| Dijon, France, 21000 | |
| Centre Georges François Leclerc | Recruiting |
| Dijon, France, 21000 | |
| Clinique Sainte Marguerite | Recruiting |
| Hyères, France, 83400 | |
| Clinique Universitaire de cancérologie-Radiothérapie | Recruiting |
| La Tronche, France, 38700 | |
| Centre Jean Bernard - Clinique Victor Hugo | Recruiting |
| Le Mans, France, 72000 | |
| Centre Oscar Lambret | Recruiting |
| Lille, France, 59020 | |
| Hopital La Timone | Recruiting |
| Marseille Cedex 05, France, 13385 | |
| Hôpital Privé Clairval | Recruiting |
| Marseilli, France, 13009 | |
| Institut Regional du Cancer de Montpellier Val d'Aurelle | Recruiting |
| Montpellier, France, 34298 | |
| Hôpital Américain de Paris | Recruiting |
| Neuilly-Sur-Seine, France, 92200 | |
| Hopital Privé des Peupliers | Completed |
| Paris, France, 75013 | |
| Hopital Saint-Louis | Recruiting |
| Paris, France, 75475 | |
| Institut du cancer courlancy | Withdrawn |
| Reims, France, 51100 | |
| Centre de radiothérapie et d'Oncologie médicale de l'Essonne | Recruiting |
| Ris Orangis, France, 91130 | |
| Institut de Cancérologie de l'Ouest (ICO) | Recruiting |
| Saint Herblain, France, 44800 | |
| Clinique Armoricaine de Radiologie | Completed |
| Saint-Brieuc, France, 22015 | |
| Hôpital d'Instruction des Armées BEGIN | Recruiting |
| Saint-Mandé, France, 94160 | |
| Institut de Cancerologie Lucien Neuwirth | Recruiting |
| Saint-Priest-En-Jarez, France, 42270 | |
| Strasbourg Oncologie Libérale | Recruiting |
| Strasbourg, France, 67000 | |
| Clinique Pasteur | Recruiting |
| Toulouse, France, 31300 | |
| CHRU Tours Hôpital Bretonneau | Recruiting |
| Tours, France, 37000 | |
| Institut de Cancérologie de Lorraine | Completed |
| Vandoeuvre-Les-Nancy, France, 54500 | |
| Hôpital Privé Océane | Withdrawn |
| Vannes, France, 56000 | |
| Gustave Roussy | Recruiting |
| Villejuif Cedex, France, 94800 | |
| Germany | |
| Städtisches Klinikum Braunschweig gGmbH - Standort Salzdahlumer | Recruiting |
| Braunschweig, Germany, 38126 | |
| Zeisigwaldkliniken Bethanien Chemnitz | Recruiting |
| Chemnitz, Germany, 9130 | |
| Diakonissenkrankenhaus Dessau | Recruiting |
| Dessau, Germany, 6846 | |
| Universitatsklinikum Frankfurt | Recruiting |
| Frankfurt, Germany, 60590 | |
| St. Antonius-Hospital Gronau GmbH | Recruiting |
| Gronau, Germany, 48599 | |
| Universitätsklinikum Jena | Recruiting |
| Jena, Germany, 7743 | |
| Klinik und Poliklinik für Urologie | Withdrawn |
| Köln, Germany, 50937 | |
| Universitätsklinikum Münster | Recruiting |
| Münster, Germany, 48149 | |
| Studienpraxis Urologie Nürtingen | Recruiting |
| Nürtingen, Germany, 72622 | |
| Gemeinschaftspraxis für Urologie in Traunstein | Withdrawn |
| Traunstein, Germany, 83278 | |
| Universitaetsklinikum Ulm | Recruiting |
| Ulm, Germany, 89081 | |
| Klinikum Weiden | Recruiting |
| Weiden, Germany, 92637 | |
| Israel | |
| Assaf Harofeh Medical Center | Recruiting |
| Beer Yaakov, Israel, 73100 | |
| Soroka Medical Center | Completed |
| Beer-Sheva, Israel, 84101 | |
| Rambam Medical Center | Recruiting |
| Haifa, Israel, 35254 | |
| Hadassah Medical Organization Ein Kerem | Recruiting |
| Jerusalem, Israel, 91120 | |
| Meir Medical Center | Recruiting |
| Kfar Saba, Israel, 44281 | |
| Rabin Medical Center | Recruiting |
| Petach-Tikva, Israel, 49100 | |
| Sheba Medical Center | Recruiting |
| Ramat-Gan, Israel, 52621 | |
| Sourasky (Ichilov) Medical Center | Recruiting |
| Tel-Aviv, Israel, 64239 | |
| Italy | |
| Reparto di Radioterapia Centro di Riferimento Oncologico | Recruiting |
| Aviano, Italy, 33081 | |
| Radioterapia Oncologica, A.O.U. San'T Orsola | Recruiting |
| Bologna, Italy, 40138 | |
| Istituto del Radio Olindo Alberti Spedali Civili Brescia | Recruiting |
| Brescia, Italy, 25123 | |
| Istituto Ricerca Contro il Cancro | Recruiting |
| Candiolo, Italy, 10060 | |
| Humanitas Centro Catanese di Oncologia | Recruiting |
| Catania, Italy, 95126 | |
| Azienda Ospedaliero Universitaria Careggi | Recruiting |
| Firenze, Italy, 50134 | |
| Ospedale San Raffaele | Completed |
| Milano, Italy, 20132 | |
| Istituto Europeo di Oncologia Servizio Radioterapia | Recruiting |
| Milano, Italy, 20141 | |
| Fondazione IRCCS Istituto Nazionale dei Tumori | Completed |
| Napoli, Italy, 80131 | |
| Ospedale Sacro Cuore Negrar-Verona | Recruiting |
| Negrar, Italy, 37024 | |
| U.O.Radioterapia Oncologica, Azienda Ospedaliera Di Perugia | Recruiting |
| Perugia, Italy, 06156 | |
| Irccs Crob | Completed |
| Rionero In Vulture, Italy, 85028 | |
| Università Campus Biomedico di Roma | Recruiting |
| Roma, Italy, 00128 | |
| Fondazione Policlinico Tor Vergata | Recruiting |
| Roma, Italy, 00133 | |
| Istituto Regina Elena, Roma | Recruiting |
| Roma, Italy, 00144 | |
| Gemelli Art ,Università Cattolica S.Cuore | Recruiting |
| Roma, Italy, 00168 | |
| Azienda Ospedaliera Sant Andrea | Recruiting |
| Roma, Italy, 00189 | |
| Istituto Clinico Humanitas | Recruiting |
| Rozzano, Italy, 20089 | |
| Korea, Republic of | |
| Kyungpook National University Chilgok Hospital | Recruiting |
| Daegu, Korea, Republic of, 41404 | |
| Chonnam National University Hwasun Hospital | Recruiting |
| Hwasun-Gun, Korea, Republic of, 519-809 | |
| Seoul National University Bundang Hospital | Recruiting |
| Seongnam-Si, Gyeonggi-Do, Korea, Republic of, 13620 | |
| Seoul National University Hospital | Recruiting |
| Seoul, Korea, Republic of, 03080 | |
| Seoul St. Mary's Hospital | Recruiting |
| Seoul, Korea, Republic of, 06591 | |
| Samsung Medical Center | Recruiting |
| Seoul, Korea, Republic of, 135 710 | |
| Ajou University Hospital | Recruiting |
| Suwon, Korea, Republic of, 443-721 | |
| Malaysia | |
| University Kebangsaan Malaysia Medical Centre | Withdrawn |
| Cheras, Malaysia, 56000 | |
| Pulau Pinang Hospital | Recruiting |
| Georgetown, Malaysia, 10990 | |
| Hospital University Sains Malaysia | Withdrawn |
| Kota Bharu, Malaysia, 15600 | |
| Hospital Kuala Lumpur | Recruiting |
| Kuala Lumpur, Malaysia, 50586 | |
| University Malaya Medical Centre | Withdrawn |
| Kuala Lumpur, Malaysia, 59100 | |
| Sarawak General Hospital | Recruiting |
| Kuching, Malaysia, 93586 | |
| National Cancer Institute | Recruiting |
| Putrajaya, Malaysia, 62250 | |
| Mexico | |
| Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C. 'SINACOR' | Recruiting |
| Culiacan, Mexico, 80230 | |
| Hospital Civil Fray Antonio Alcalde | Recruiting |
| Guadalajara, Mexico, 44280 | |
| Hospital Aranda de la Parra S.A. de C.V. | Recruiting |
| Leon, Mexico, 37000 | |
| Centro Medico Nacional Siglo XXI IMSS | Recruiting |
| Mexico, Mexico, 06720 | |
| Clinica Lomas Altas | Withdrawn |
| Mexico, Mexico, 11950 | |
| Instituto Nacional de Cancerologia | Withdrawn |
| Mexico, Mexico, 14080 | |
| Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán | Not yet recruiting |
| Mexico, Mexico, 14080 | |
| Centro de Investigacion Clinica Chapultepec | Recruiting |
| Morelia, Mexico, 58260 | |
| Centro Oncologico Estatal ISSEMYM | Withdrawn |
| Toluca, Mexico, 50180 | |
| Consultorio Medico | Recruiting |
| Zapopan, Mexico, 45040 | |
| Netherlands | |
| Mc Alkmaar | Completed |
| Alkmaar, Netherlands, 1815 JD | |
| NKI-AVL, Amsterdam | Completed |
| Amsterdam, Netherlands, 1066 CX | |
| VUMC Amsterdam | Recruiting |
| Amsterdam, Netherlands, 1081 HV | |
| Rijnstate Ziekenhuis | Withdrawn |
| Arnhem, Netherlands, 6815 AD | |
| MC Haaglanden | Completed |
| Den Haag, Netherlands, 2512 VA | |
| Catharinaziekenhuis | Withdrawn |
| Eindhoven, Netherlands, 5623 EJ | |
| Spaarne Gasthuis | Withdrawn |
| Hoofddorp, Netherlands, 2134 TM | |
| UMC St. Radboud | Completed |
| Nijmegen, Netherlands, 6525 GA | |
| Canisius-Wilhelminaziekenhuis | Completed |
| Nijmegen, Netherlands, 6532 SZ | |
| Erasmus MC | Recruiting |
| Rotterdam, Netherlands, 3075 EA | |
| Poland | |
| Bialostockie Centrum Onkologii im. Marii Sklodowskiej-Curie w Bialymstoku | Recruiting |
| Bialystok, Poland, 15-027 | |
| Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy | Recruiting |
| Bydgoszcz, Poland, 85-796 | |
| Szpitale Pomorskie Sp. z o.o. | Recruiting |
| Gdynia, Poland, 81-519 | |
| Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie w Gliwicach | Recruiting |
| Gliwice, Poland, 44-101 | |
| Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach | Completed |
| Kielce, Poland, 25-734 | |
| Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi | Recruiting |
| Lodz, Poland, 93-513 | |
| SPZOZ Ministerstwa Spraw Wewnętrznych z Warminsko-Mazurskim Centrum Onkologii w Olsztynie | Recruiting |
| Olsztyn, Poland, 10-228 | |
| Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie w Poznaniu | Recruiting |
| Poznan, Poland, 61-866 | |
| Affidea Onkoterapia Sp z o.o.- Miedzynarodowe Centrum Onkologii | Recruiting |
| Walbrzych, Poland, 58-309 | |
| Romania | |
| Institutul Oncologic Prof.Dr.Al.Trestioreanu Bucuresti | Recruiting |
| Bucuresti, Romania, 022328 | |
| Institut Clinic Fundeni | Withdrawn |
| Bucuresti, Romania, 22328 | |
| Institut Clinic Fundeni | Recruiting |
| Bucuresti, Romania, 22328 | |
| Prof. Dr. Theodor Burghele Clinical Hospital | Recruiting |
| Bucuresti, Romania, 50659 | |
| Institutul Oncologic 'Prof Dr. Ion Chiricuta' Cluj-Napoca | Recruiting |
| Cluj-Napoca, Romania, 400015 | |
| Medisprof SRL | Withdrawn |
| Cluj-Napoca, Romania, 400058 | |
| Radiotherapy Center Cluj | Recruiting |
| Floresti, Romania, 407280 | |
| Institutul Regional de Oncologie Iasi | Recruiting |
| Iasi, Romania, 700483 | |
| RTC Radiology Therapeutic Center | Recruiting |
| Otopeni, Romania, 75100 | |
| Spital Municipal Ploiesti | Recruiting |
| Ploiesti, Romania, 100337 | |
| Spitalul Clinic Judetean Sibiu | Completed |
| Sibiu, Romania, 550245 | |
| SC. Clinica Polisano SRL | Withdrawn |
| Sibiu, Romania, 550253 | |
| Spitalul Clinic Judetean Mures | Recruiting |
| Targu Mures, Romania, 540141 | |
| Spitalul Clinic Municipal de Urgenta Timisoara | Completed |
| Timisoara, Romania, 300594 | |
| Russian Federation | |
| Altai Regional Oncology Dispensary | Recruiting |
| Barnaul, Russian Federation, 656049 | |
| Ivanovo Regional Oncology Dispensary | Recruiting |
| Ivanovo, Russian Federation, 153040 | |
| FSBSI 'N. N. Blokhin Russian Cancer Research Center' | Recruiting |
| Moscow, Russian Federation, 115478 | |
| Russian Scientific Center of Roentgenoradiology | Recruiting |
| Moscow, Russian Federation, 117997 | |
| Moscow City Clinical Hospital # 62 | Recruiting |
| Moscow, Russian Federation, 125130 | |
| Hertzen Oncology Research Institute | Recruiting |
| Moscow, Russian Federation, 125284 | |
| Semashko Regional Clinical Hospital | Recruiting |
| Nizhny Novgorod, Russian Federation, 603126 | |
| National Medical Radiological Research Center | Recruiting |
| Obninsk, Russian Federation, 249036 | |
| Clinical Oncology Dispansary | Recruiting |
| Omsk, Russian Federation, 644013 | |
| LLC Novaya Clinica | Recruiting |
| Pyatigorsk, Russian Federation, 357500 | |
| Hospital for War Veterans | Completed |
| Rostov-On-Don, Russian Federation, 344037 | |
| Regional Clinical Oncology Dispensary | Recruiting |
| Ryazan, Russian Federation, 390011 | |
| Leningrad Regional Oncology Dispensary | Recruiting |
| Saint-Petersburg, Russian Federation, 191104 | |
| City Oncology Dispensary | Recruiting |
| Saint-Petersburg, Russian Federation, 197022 | |
| Republican Oncology Dispensary | Recruiting |
| Saransk, Russian Federation, 430032 | |
| Regional Oncology Dispansary #2 | Withdrawn |
| Saratov, Russian Federation, 410053 | |
| Oncologic Dispensary No.2 | Withdrawn |
| Sochi, Russian Federation, 354057 | |
| Russian Scientific Center of Radiology and Surgical Technologies | Recruiting |
| St Petersburg, Russian Federation, 197758 | |
| Tambov Regional Oncology Clinical Dispansary | Recruiting |
| Tambov, Russian Federation, 392013 | |
| Multifunctional clinical medical center 'Medical city' | Recruiting |
| Tyumen, Russian Federation, 625041 | |
| Bashkiria State Medical University | Recruiting |
| Ufa, Russian Federation, 450000 | |
| Vologda Regional Oncological Dispensary | Recruiting |
| Vologda, Russian Federation, 160012 | |
| Spain | |
| Hosp. Univ. de Cruces | Recruiting |
| Barakaldo, Spain, 48903 | |
| Hosp. Univ. Vall D Hebron | Recruiting |
| Barcelona, Spain, 08035 | |
| Hosp. de La Santa Creu I Sant Pau | Recruiting |
| Barcelona, Spain, 08041 | |
| Fund. Hosp. Prov De Castellon | Recruiting |
| Castellon, Spain, 12002 | |
| Ico Hospitalet (catalan Institute Of Oncology) | Recruiting |
| Hospitalet De Llobregat, Spain, 8907 | |
| Hosp. Univ. de Gran Canaria Dr. Negrin | Recruiting |
| Las Palmas De Gran Canaria, Spain, 35010 | |
| Hosp. Univ. de La Princesa | Recruiting |
| Madrid, Spain, 28006 | |
| Hosp. Univ. Ramon Y Cajal | Recruiting |
| Madrid, Spain, 28034 | |
| Hosp. Univ. 12 de Octubre | Recruiting |
| Madrid, Spain, 28041 | |
| Centro Integral Oncológico Clara Campal | Recruiting |
| Madrid, Spain, 28050 | |
| Hosp. Virgen de La Victoria | Recruiting |
| Málaga, Spain, 29010 | |
| Hosp. Univ. Sant Joan De Reus | Recruiting |
| Reus, Spain, 43204 | |
| Hosp. Clinico Univ. de Santiago | Recruiting |
| Santiago De Compostela, Spain, 15706 | |
| Hosp. Virgen Del Rocio | Recruiting |
| Sevilla, Spain, 41013 | |
| Sweden | |
| Onkologiska kliniken Radiumhemmet | Recruiting |
| Stockholm, Sweden, 17176 | |
| Urologiska kliniken | Recruiting |
| Umeå, Sweden, 90185 | |
| Urologiska kliniken Örebro | Recruiting |
| Örebro, Sweden, 70185 | |
| Taiwan | |
| Kaohsiung Veterans General Hospital | Recruiting |
| Kaohsiung, Taiwan, 81362 | |
| Chang Gung Memorial Hospital | Completed |
| Kaohsiung, Taiwan, 83301 | |
| China Medical University Hospital | Recruiting |
| Taichung, Taiwan, 40447 | |
| National Cheng Kung University Hospital | Recruiting |
| Tainan, Taiwan, 70403 | |
| National Taiwan University Hospital | Recruiting |
| Taipei City, Taiwan, 10002 | |
| Taipei Veterans General Hospital | Recruiting |
| Taipei, Taiwan, 11217 | |
| Chang Gung Memorial Hospital | Recruiting |
| Taoyuan, Taiwan, 33305 | |
| Turkey | |
| Başkent University Medical Faculty Adana Application and Research Center | Recruiting |
| Adana, Turkey, 01250 | |
| Hacettepe University Medical Faculty | Recruiting |
| Ankara, Turkey, 06100 | |
| Gazi University Medical Faculty | Recruiting |
| Ankara, Turkey, 06560 | |
| Ataturk Training and Research Hospital | Recruiting |
| Ankara, Turkey, 06800 | |
| Trakya University Medical Faculty | Recruiting |
| Edirne, Turkey, 22030 | |
| Istanbul University Cerrahpasa Medical Faculty | Recruiting |
| Istanbul, Turkey, 34098 | |
| Ege Universitesi Tip Fakultesi | Recruiting |
| İzmir, Turkey, 35040 | |
| Izmır Medical Park Hospital | Recruiting |
| İzmir, Turkey, 35580 | |
| Erciyes University Medical Faculty | Recruiting |
| Kayseri, Turkey, 38039 | |
| Kocaeli University Medical Faculty | Recruiting |
| Kocaeli, Turkey, 41380 | |
| Ukraine | |
| Dnipropetrovsk State Medical Academy, Dnipropetrovk State Clinical Hospital NA Mechnikov I.I. | Recruiting |
| Dnipro, Ukraine, 49005 | |
| Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4 | Recruiting |
| Dnipro, Ukraine, 49102 | |
| Municipal non-profit enterprise 'Regional Center of Oncology' | Recruiting |
| Khakhiv, Ukraine, 61070 | |
| State Institution National Cancer Institute | Recruiting |
| Kyiv, Ukraine, 03022 | |
| State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center | Recruiting |
| Kyiv, Ukraine, 03115 | |
| Lviv Clinical Regional Hospital | Recruiting |
| Lviv, Ukraine, 79031 | |
| United Kingdom | |
| Aberdeen Royal Infirmary | Recruiting |
| Aberdeen, United Kingdom, AB25 2ZB | |
| University Hospitals Birmingham NHS Trust, | Recruiting |
| Birmingham, United Kingdom, B15 2PR | |
| Royal Blackburn Hospital | Withdrawn |
| Blackburn, United Kingdom, BB2 3HH | |
| Bristol Haematology and Oncology Centre | Recruiting |
| Bristol, United Kingdom, BS2 8ED | |
| Royal Derby Hospital | Recruiting |
| Derby, United Kingdom, DE22 3NE | |
| Beatson West Of Scotland Cancer Centre | Recruiting |
| Glasgow, United Kingdom, G84 7SSE | |
| Churchill Hospital | Recruiting |
| Oxford, United Kingdom, OX3 7LE | |
| Derriford Hospital | Recruiting |
| Plymouth, United Kingdom, PL6 8qh | |
| Lancashire Teaching Hospitals NHS Foundation Trust Royal Preston Hospital | Recruiting |
| Preston, United Kingdom, PR2 9HT | |
| The University Of Sheffield, Weston Park Hospital | Recruiting |
| Sheffield, United Kingdom, S10 2SJ | |
| Royal Marsden Hospital | Recruiting |
| Sutton, United Kingdom, SM2 5PT | |
| New Cross Hospital | Recruiting |
| Wolverhampton, United Kingdom, WV10 0QP | |
Sponsors and Collaborators
Aragon Pharmaceuticals, Inc.
Investigators
| Study Director: | Aragon Pharmaceuticals, Inc. Clinical Trial | Aragon Pharmaceuticals, Inc. |
Additional Information:
| Responsible Party: | Aragon Pharmaceuticals, Inc. |
| ClinicalTrials.gov Identifier: | NCT02531516 History of Changes |
| Other Study ID Numbers: |
CR106935 56021927PCR3003 ( Other Identifier: Aragon Pharmaceuticals, Inc. ) 2015-003007-38 ( EudraCT Number ) |
| First Posted: | August 24, 2015 Key Record Dates |
| Last Update Posted: | April 6, 2018 |
| Last Verified: | April 2018 |
| Studies a U.S. FDA-regulated Device Product: | No | |
Keywords provided by Aragon Pharmaceuticals, Inc.:
|
Prostatic neoplasms Prostate Cancer High-Risk prostate cancer JNJ-56021927 Apalutamide |
ATLAS Radiation Long-term hormone therapy Localized or locally advanced prostate cancer Janssen |
Additional relevant MeSH terms:
|
Prostatic Neoplasms Genital Neoplasms, Male Urogenital Neoplasms Neoplasms by Site Neoplasms Prostatic Diseases Genital Diseases, Male |
Hormones Bicalutamide Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Androgen Antagonists Hormone Antagonists Antineoplastic Agents |