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Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases

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ClinicalTrials.gov Identifier: NCT02490878
Recruitment Status : Recruiting
First Posted : July 7, 2015
Last Update Posted : May 8, 2018
Sponsor:
Collaborators:
National Cancer Institute (NCI)
Genentech, Inc.
Information provided by (Responsible Party):
Alliance for Clinical Trials in Oncology

Brief Summary:
This randomized phase II study aims to investigate whether the addition of bevacizumab to standard corticosteroid therapy results in greater improvement in symptoms and less treatment-induced symptoms compared with standard corticosteroid therapy for patients with symptomatic brain radionecrosis following radiosurgery. It is hypothesized that the addition of bevacizumab to standard care corticosteroids will reduce treatment-induced toxicities and improve neurologic impairments in patients with brain radionecrosis following radiosurgery for brain metastases.

Condition or disease Intervention/treatment Phase
Radionecrosis Brain Metastases Drug: bevacizumab Drug: corticosteroids Other: placebo Phase 2

Detailed Description:

This is a randomized double-blinded phase II study of corticosteroids with bevacizumab vs. corticosteroids with placebo for brain radionecrosis following radiosurgery for brain metastases. This is a two-arm clinical trial with parallel group design for longitudinal quality of life endpoint. Patients will be stratified according to age (≤ 65 years vs. > 65 years), pathological confirmation of necrosis (yes vs. no), MDASI-BT mean global score (symptom + interference scores) ( < 4.0 vs. > 4.0) and prior whole brain radiotherapy (yes vs. no). The primary and secondary objectives are detailed below.

Primary Objective:

To investigate whether the addition of bevacizumab to standard corticosteroid therapy results in greater improvement in symptoms (clinical and patient-reported symptom improvement associated with radionecrosis and less radionecrosis treatment-induced symptoms) compared with standard corticosteroid therapy.

Secondary Objectives:

  1. To evaluate the toxicity profile associated with bevacizumab and corticosteroid therapy.
  2. To compare self-reported health related quality of life (HRQOL) using LASA, Dexamethasone Symptoms Questionnaire-Chronic (DSQ-C), and MDASI-BT symptom and interference score between treatment arms.
  3. To compare intracranial progression-free survival and time to maximum radiographic response between treatment arms.
  4. To compare the dose and duration of corticosteroids required between treatment arms and correlate steroid requirement with DSQ-C and MDASI-BT scores.

Patient event monitoring will occur every 2 months after treatment up to 6 months. Then event monitoring will occur up to one year.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 130 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Supportive Care
Official Title: Randomized Phase II Study: Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases
Study Start Date : April 2016
Estimated Primary Completion Date : April 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Steroids
Drug Information available for: Bevacizumab
U.S. FDA Resources

Arm Intervention/treatment
Experimental: bevacizumab + corticosteroids

The patient will receive bevacizumab 10 mg/kg IV given on days 1 and 15 of a 28 day cycle for 4 cycles. Once the patient has started the study treatment, the dose of corticosteroids will be tapered every 5 days (e.g., dexamethasone 2 mg or prednisone 15 mg per taper), as tolerated, under the management of the treating MD. If patients deteriorate while tapering, dexamethasone will be increased up to a maximum of 16 mg per day, as per treating MD, to manage symptoms.

Patients who meet the criteria for clinical progression will be treated as per treating MD.

Drug: bevacizumab
IV
Drug: corticosteroids
IV
Experimental: placebo + corticosteroids

The patient will receive placebo 0.9% NaCl volume equal to bevacizumab volume added to 100 mL bag of 0.9% NaCl delivered IV given on days 1 and 15 of a 28-day cycle for 4 cycles. Once the patient has started the study treatment, the dose of corticosteroids will be tapered every 5 days (e.g., dexamethasone 2 mg or prednisone 15 mg per taper), as tolerated, under the management of the treating MD. If patients deteriorate while tapering, dexamethasone will be increased up to a maximum of 16 mg per day, as per treating MD, to manage symptoms.

Patients who meet the criteria for clinical progression will be allowed to receive bevacizumab according to the protocol.

Drug: corticosteroids
IV
Other: placebo
IV



Primary Outcome Measures :
  1. Patient-reported outcome (symptoms) of radionecrosis [ Time Frame: Up to 8 weeks ]

Secondary Outcome Measures :
  1. Toxicities associated with bevacizumab and corticosteroids in patients with radionecrosis using CTCAE Version 4.0 and DSQ-C. [ Time Frame: Up to 1.5 years post-treatment ]
  2. Quality of life measure using the Single Item Linear Analogue Scale (LASA) [ Time Frame: Up to 1.5 years post-treatment ]
  3. Quality of life measure using the Dexamethasone Symptoms Questionnaire - Chronic (DSQ-C) [ Time Frame: Up to 1.5 years post-treatment ]
  4. Quality of life measure using the The M. D. Anderson Symptom Inventory-Brain Tumor Module (MDASI-BT) score. [ Time Frame: Up to 1.5 years post-treatment ]
  5. Progression free survival [ Time Frame: Up to 16 weeks ]
  6. Corticosteroid dose over time [ Time Frame: Up to 16 weeks ]
  7. Maximum radiographic response [ Time Frame: Up to 16 weeks ]
  8. Time to stopping corticosteroids [ Time Frame: Up to 16 weeks ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Pre-Registration Eligibility Criteria:

  1. Patients who present with symptomatic brain radionecrosis after they have received radiosurgery for brain metastases from primary solid tumor including but not limited to lung, breast, colorectal cancer but excluding melanoma, choriocarcinoma, renal cell carcinoma or gliomas
  2. Patients at institutions that elect to utilize central imaging review to confirm eligibility must be pre-registered prior to submission of these images; images should be submitted as soon as possible after the pre-registration magnetic resonance imaging (MRI) is obtained; turnaround time for this review will be =< 72 business hours after receipt of images by the Imaging and Radiation Oncology Core (IROC)
  3. Patients at institutions that elect to confirm eligibility locally may be pre-registered at the same time as they are randomized

Registration/Randomization Eligibility Criteria:

  1. A diagnosis of radionecrosis will be based on a clinical onset of symptoms and radiological findings of radionecrosis at 3-24 months following radiosurgery, with or without pathological confirmation.

    1.1 'Symptomatic' brain radionecrosis to at least one lesion following radiosurgery treatment for brain metastases where 'symptomatic' is defined as:

    1.1.1 New or increasing headache associated with mass effect, sensory or motor abnormality, cognitive changes, speech difficulty, balance or coordination difficulty, cranial nerve deficits

    1.1.2 Symptoms are persistent or worsening despite administration of at least dexamethasone 4 mg (or equivalent corticosteroid) daily for 1 week

    1.2 Clinical eligibility supported by central imaging real-time review. The presence of at least the following conventional MR image characteristic:

    1.2.1 Conventional MR - Lesion quotient of < 0.3, where lesion quotient is defined as the proportional value of the maximum axial cross-sectional area of the T2-weighted defined lesion over the maximum axial cross-sectional area of the contrast-enhancing lesion on the T1-weighted post-gadolinium sequence on a comparable axial slice. If the conventional MR findings are not seen, the following dynamic susceptibility-contrast (DSC) MR characteristics may be used to meet eligibility for this study.

    1.2.2 DSC MR - The cut-offs below will be based on GRE EPI DSC perfusion images, acquired without using a gadolinium pre-load:

    1.2.2.1 Relative cerebral blood volume (rCBV) <1.5 in the enhancing- lesion relative to normal-appearing white matter (NAWM)

    1.2.2.2. Percentage of signal recovery (PSR) > 76%, where PSR is determined by comparing the lower signal intensity during passage of the contrast bolus with the post-contrast signal intensity on the signal intensity-time curve

    1.2.3 Centers that standardly use PET or MRS to determine a diagnosis of radionecrosis are permitted to use these modalities to assist in their patient selection; however the criteria described for conventional MR and/or DSC should also be met for study eligibility. Both PET and MRS are not mandatory for study eligibility.

  2. Prior to start of treatment

    2.1 Must have been taking a stable dose of corticosteroids for symptom management for at least 1 week before baseline MRI.

    2.2 No systemic therapy within 2 weeks prior to registration or plan for systemic therapy within the first 8 weeks after study registration. The protocol provides a list of 'approved systemic' therapies that are allowed for concurrent use with bevacizumab.

    2.3 No bevacizumab ≤ 3 months of study registration.

    2.4 Central imaging real-time review (72 hour turn around) to confirm eligibility.

  3. Not pregnant and not nursing, because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown. Therefore, for women of childbearing potential only, a negative urine or serum pregnancy test done ≤ 14 days prior to registration and confirmation they are not nursing is required.
  4. Age ≥ 18 years
  5. Karnofsky Performance Status ≥ 60%
  6. Required Initial Laboratory Values ≤14 days of registration:

    6.1 Absolute Neutrophil Count (ANC) ≥ 1,500/mm^3

    6.2 Platelet Count ≥ 100,000/mm3

    6.3 Hemoglobin ≥ 10 g/dL*

    6.3.1 allowing transfusion or other intervention to achieve this minimum hemoglobin

    6.4 BUN < 30 mg/dL

    6.5 Creatinine < 1.7 mg/dL

    6.6 Bilirubin ≤ 2.0 mg/dL

    6.7 ALT ≤ 3.0 x upper limits of normal (ULN)

    6.8 AST ≤ 3.0 x ULN

    6.9 INR <1.5 x ULN**

    6.9.1 unless patients are receiving anti-coagulation therapy. Patients receiving anti-coagulation therapy with an agent such warfarin or heparin are allowed to participate if INR ≤ 3.0.**

    6.10 UPC Ratio <0.5 or if ≥ 0.5

    6.10.1 24-hour urine protein must be <1000 mg

  7. Able to participate in patient-report outcomes (MDASI-BT, DSQ-C, LASA) questionnaires.

    Assistance by research personnel is acceptable if participant has disabilities that make reading or writing difficult.

  8. No evidence of recent hemorrhage at pre-registration MRI of the brain, however the following are permitted: presence of hemosiderin, resolving hemorrhagic changes related to surgery, and presence of punctate hemorrhage in the tumor.
  9. No excess risk of bleeding (any of the following):

    9.1 Bleeding diathesis or coagulopathy

    9.2 Thrombocytopenia

    9.3 Major surgical procedure, open biopsy, or significant traumatic injury within the past 28 days or anticipation of need for major surgical procedure during the course of the study.

    9.4 Minor surgical procedures, stereotactic biopsy, fine needle aspiration, or core biopsy within the past 7 days.

  10. No clinically significant cardiovascular disease.

    10.1 No uncontrolled hypertension (systolic blood pressure ≤ 160 mm Hg or diastolic ≤ 100 mm Hg). Patients with hypertension must be adequately controlled with appropriate anti-hypertensive therapy or diet.

    10.2 No history of arterial thrombotic events within the past 6 months, including:

    10.2.1 transient ischemic attack (TIA)

    10.2.2 cerebrovascular accident (CVA)

    10.2.3 peripheral arterial thrombus

    10.2.4 unstable angina or angina requiring surgical or medial intervention

    10.2.5 myocardial infarction (MI)

    10.2.6 significant peripheral artery disease (i.e., claudication on less than one block)

    10.2.7 significant vascular disease (i.e., aortic aneurysm, history of aortic dissection)

    10.3 Patients who have had a deep vein thrombosis or pulmonary embolus within the past 6 months are eligible if they are on stable therapeutic anticoagulation.

    10.4 No current New York Heart Association classification II, III, or IV congestive heart failure.

  11. No history of bowel obstruction, abdominal fistula, gastrointestinal perforation, or intra- abdominal abscess within past 12 months.
  12. No central lung metastases with excessive active bleeding.
  13. No uncontrolled intercurrent illness including, but not limited to any of the following:

    ongoing or active infection requiring IV antibiotics, cardiac arrhythmia, or psychiatric illness and/or social situations that would limit compliance with study requirements.

  14. No history of serious non-healing wound, ulcer, or bone fractures.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02490878


Contacts
Contact: Caroline Chung, MD 713-745-5422

  Hide Study Locations
Locations
United States, Alaska
Anchorage Associates in Radiation Medicine Active, not recruiting
Anchorage, Alaska, United States, 98508
Anchorage Radiation Therapy Center Active, not recruiting
Anchorage, Alaska, United States, 99504
Alaska Breast Care and Surgery LLC Active, not recruiting
Anchorage, Alaska, United States, 99508
Alaska Oncology and Hematology LLC Active, not recruiting
Anchorage, Alaska, United States, 99508
Alaska Women's Cancer Care Active, not recruiting
Anchorage, Alaska, United States, 99508
Anchorage Oncology Centre Active, not recruiting
Anchorage, Alaska, United States, 99508
Katmai Oncology Group Active, not recruiting
Anchorage, Alaska, United States, 99508
Providence Alaska Medical Center Active, not recruiting
Anchorage, Alaska, United States, 99508
United States, California
PCR Oncology Recruiting
Arroyo Grande, California, United States, 93420
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Providence Saint Joseph Medical Center/Disney Family Cancer Center Active, not recruiting
Burbank, California, United States, 91505
UC San Diego Moores Cancer Center Recruiting
La Jolla, California, United States, 92093
Contact: David E. Piccioni    858-822-5354    cancercto@ucsd.edu   
Principal Investigator: David E. Piccioni         
United States, Delaware
Beebe Medical Center Recruiting
Lewes, Delaware, United States, 19958
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Delaware Clinical and Laboratory Physicians PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Helen F Graham Cancer Center Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Medical Oncology Hematology Consultants PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Regional Hematology and Oncology PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Beebe Health Campus Recruiting
Rehoboth Beach, Delaware, United States, 19971
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Nanticoke Memorial Hospital Recruiting
Seaford, Delaware, United States, 19973
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Christiana Care Health System-Wilmington Hospital Recruiting
Wilmington, Delaware, United States, 19801
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
United States, Florida
Boca Raton Regional Hospital Recruiting
Boca Raton, Florida, United States, 33486
Contact: Sajeel A. Chowdhary    561-955-4800      
Principal Investigator: Sajeel A. Chowdhary         
Halifax Health Medical Center-Centers for Oncology Recruiting
Daytona Beach, Florida, United States, 32114
Contact: Ruby Anne E. Deveras    773-702-9171    protocols@AllianceNCTN.org   
Principal Investigator: Ruby Anne E. Deveras         
Baptist MD Anderson Cancer Center Recruiting
Jacksonville, Florida, United States, 32207
Contact: Robert Cavaliere    904-202-7051      
Principal Investigator: Robert Cavaliere         
Mayo Clinic in Florida Active, not recruiting
Jacksonville, Florida, United States, 32224-9980
Moffitt Cancer Center Recruiting
Tampa, Florida, United States, 33612
Contact: Sepideh Mokhtari    800-456-7121    canceranswers@moffitt.org   
Principal Investigator: Sepideh Mokhtari         
United States, Georgia
Emory University Hospital/Winship Cancer Institute Recruiting
Atlanta, Georgia, United States, 30322
Contact: Hui-Kuo G. Shu    404-778-1868      
Principal Investigator: Hui-Kuo G. Shu         
Memorial Health University Medical Center Recruiting
Savannah, Georgia, United States, 31404
Contact: Christopher E. Haberman    912-350-8568      
Principal Investigator: Christopher E. Haberman         
Summit Cancer Care-Memorial Recruiting
Savannah, Georgia, United States, 31404
Contact: Christopher E. Haberman    912-350-8568      
Principal Investigator: Christopher E. Haberman         
Low Country Cancer Care Associates PC Recruiting
Savannah, Georgia, United States, 31405
Contact: Christopher E. Haberman    912-350-8568      
Principal Investigator: Christopher E. Haberman         
Summit Cancer Care-Candler Recruiting
Savannah, Georgia, United States, 31405
Contact: Christopher E. Haberman    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Christopher E. Haberman         
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Luke's Mountain States Tumor Institute Active, not recruiting
Boise, Idaho, United States, 83712
Saint Alphonsus Cancer Care Center-Caldwell Recruiting
Caldwell, Idaho, United States, 83605
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Kootenai Medical Center Recruiting
Coeur d'Alene, Idaho, United States, 83814
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Walter Knox Memorial Hospital Recruiting
Emmett, Idaho, United States, 83617
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Luke's Mountain States Tumor Institute - Fruitland Active, not recruiting
Fruitland, Idaho, United States, 83619
Idaho Urologic Institute-Meridian Recruiting
Meridian, Idaho, United States, 83642
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Luke's Mountain States Tumor Institute - Meridian Active, not recruiting
Meridian, Idaho, United States, 83642
Saint Alphonsus Medical Center-Nampa Recruiting
Nampa, Idaho, United States, 83686
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Luke's Mountain States Tumor Institute - Nampa Active, not recruiting
Nampa, Idaho, United States, 83686
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Kootenai Cancer Clinic Recruiting
Sandpoint, Idaho, United States, 83864
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Saint Luke's Mountain States Tumor Institute-Twin Falls Active, not recruiting
Twin Falls, Idaho, United States, 83301
United States, Illinois
Rush - Copley Medical Center Recruiting
Aurora, Illinois, United States, 60504
Contact: Kendrith M. Rowland    630-978-6212    Cancer.Research@rushcopley.com   
Principal Investigator: Kendrith M. Rowland         
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Aidnag Z. Diaz    312-942-5498    clinical_trials@rush.edu   
Principal Investigator: Aidnag Z. Diaz         
Carle on Vermilion Recruiting
Danville, Illinois, United States, 61832
Contact: Kendrith M. Rowland    630-978-6212    Cancer.Research@rushcopley.com   
Principal Investigator: Kendrith M. Rowland         
Carle Physician Group-Effingham Recruiting
Effingham, Illinois, United States, 62401
Contact: Kendrith M. Rowland    630-978-6212    Cancer.Research@rushcopley.com   
Principal Investigator: Kendrith M. Rowland         
Carle Physician Group-Mattoon/Charleston Recruiting
Mattoon, Illinois, United States, 61938
Contact: Kendrith M. Rowland    630-978-6212    Cancer.Research@rushcopley.com   
Principal Investigator: Kendrith M. Rowland         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Kendrith M. Rowland    630-978-6212    Cancer.Research@rushcopley.com   
Principal Investigator: Kendrith M. Rowland         
The Carle Foundation Hospital Recruiting
Urbana, Illinois, United States, 61801
Contact: Kendrith M. Rowland    630-978-6212    Cancer.Research@rushcopley.com   
Principal Investigator: Kendrith M. Rowland         
Rush-Copley Healthcare Center Recruiting
Yorkville, Illinois, United States, 60560
Contact: Kendrith M. Rowland    630-978-6212    Cancer.Research@rushcopley.com   
Principal Investigator: Kendrith M. Rowland         
United States, Indiana
Deaconess Clinic Downtown Recruiting
Evansville, Indiana, United States, 47713
Contact: Kendrith M. Rowland    877-654-0311      
Principal Investigator: Kendrith M. Rowland         
Memorial Regional Cancer Center Day Road Recruiting
Mishawaka, Indiana, United States, 46545
Contact: Thomas J. Reid    800-284-7370      
Principal Investigator: Thomas J. Reid         
Chancellor Center for Oncology Recruiting
Newburgh, Indiana, United States, 47630
Contact: Kendrith M. Rowland    812-426-9576      
Principal Investigator: Kendrith M. Rowland         
Reid Health Active, not recruiting
Richmond, Indiana, United States, 47374
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Thomas J. Reid    800-284-7370      
Principal Investigator: Thomas J. Reid         
United States, Iowa
Iowa Methodist Medical Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    515-239-2621      
Principal Investigator: Robert J. Behrens         
Medical Oncology and Hematology Associates-Des Moines Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    515-239-2621      
Principal Investigator: Robert J. Behrens         
Broadlawns Medical Center Recruiting
Des Moines, Iowa, United States, 50314
Contact: Robert J. Behrens    515-239-2621      
Principal Investigator: Robert J. Behrens         
Iowa Lutheran Hospital Recruiting
Des Moines, Iowa, United States, 50316
Contact: Robert J. Behrens    515-239-2621      
Principal Investigator: Robert J. Behrens         
Methodist West Hospital Recruiting
West Des Moines, Iowa, United States, 50266-7700
Contact: Robert J. Behrens    515-239-2621      
Principal Investigator: Robert J. Behrens         
United States, Kansas
Central Care Cancer Center - Garden City Recruiting
Garden City, Kansas, United States, 67846
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Central Care Cancer Center - Great Bend Recruiting
Great Bend, Kansas, United States, 67530
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Kansas Institute of Medicine Cancer and Blood Center Recruiting
Lenexa, Kansas, United States, 66219
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Minimally Invasive Surgery Hospital Recruiting
Lenexa, Kansas, United States, 66219
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Menorah Medical Center Recruiting
Overland Park, Kansas, United States, 66209
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Luke's South Hospital Recruiting
Overland Park, Kansas, United States, 66213
Contact: Rakesh Gaur    773-702-9171    protocols@AllianceNCTN.org   
Principal Investigator: Rakesh Gaur         
United States, Massachusetts
Alliance for Clinical Trials in Oncology Recruiting
Boston, Massachusetts, United States, 02115
Contact: Caroline Chung    713-745-5422    cchung3@mdanderson.org   
Principal Investigator: Caroline Chung         
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
University of Michigan Comprehensive Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Michelle M. Kim    800-865-1125      
Principal Investigator: Michelle M. Kim         
IHA Hematology Oncology Consultants-Brighton Recruiting
Brighton, Michigan, United States, 48114
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Joseph Mercy Brighton Recruiting
Brighton, Michigan, United States, 48114
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
IHA Hematology Oncology Consultants-Canton Recruiting
Canton, Michigan, United States, 48188
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Joseph Mercy Canton Recruiting
Canton, Michigan, United States, 48188
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Caro Cancer Center Recruiting
Caro, Michigan, United States, 48723
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
IHA Hematology Oncology Consultants-Chelsea Recruiting
Chelsea, Michigan, United States, 48118
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Joseph Mercy Chelsea Recruiting
Chelsea, Michigan, United States, 48118
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Hematology Oncology Consultants-Clarkston Recruiting
Clarkston, Michigan, United States, 48346
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Newland Medical Associates-Clarkston Recruiting
Clarkston, Michigan, United States, 48346
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Beaumont Hospital-Dearborn Active, not recruiting
Dearborn, Michigan, United States, 48124
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Great Lakes Cancer Management Specialists-Doctors Park Recruiting
East China Township, Michigan, United States, 48054
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Botsford Hospital Active, not recruiting
Farmington, Michigan, United States, 48336-5919
Genesee Cancer and Blood Disease Treatment Center Recruiting
Flint, Michigan, United States, 48503
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Genesee Hematology Oncology PC Recruiting
Flint, Michigan, United States, 48503
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Hurley Medical Center Recruiting
Flint, Michigan, United States, 48503
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Recruiting
Grosse Pointe Woods, Michigan, United States, 48236
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Lymphoma Clinic of Michigan Recruiting
Grosse Pointe Woods, Michigan, United States, 48236
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Michigan Breast Specialists-Grosse Pointe Woods Recruiting
Grosse Pointe Woods, Michigan, United States, 48236
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
William Beaumont Hospital-Grosse Point Active, not recruiting
Grosse Pointe, Michigan, United States, 48230
Allegiance Health Suspended
Jackson, Michigan, United States, 49201
Sparrow Hospital Recruiting
Lansing, Michigan, United States, 48912
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Hope Cancer Clinic Recruiting
Livonia, Michigan, United States, 48154
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Great Lakes Cancer Management Specialists-Macomb Medical Campus Recruiting
Macomb, Michigan, United States, 48044
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Michigan Breast Specialists-Macomb Township Recruiting
Macomb, Michigan, United States, 48044
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Mary's Oncology/Hematology Associates of Marlette Recruiting
Marlette, Michigan, United States, 48453
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Assarian Cancer Center Recruiting
Novi, Michigan, United States, 48374-1236
Contact: Michael J. Kraut    248-849-5337    jaswinder.grewal@stjohn.org   
Principal Investigator: Michael J. Kraut         
21st Century Oncology-Pontiac Recruiting
Pontiac, Michigan, United States, 48341
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Hope Cancer Center Recruiting
Pontiac, Michigan, United States, 48341
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Newland Medical Associates-Pontiac Recruiting
Pontiac, Michigan, United States, 48341
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Huron Medical Center PC Recruiting
Port Huron, Michigan, United States, 48060
Contact: John A. Ellerton    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Lake Huron Medical Center Recruiting
Port Huron, Michigan, United States, 48060
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Great Lakes Cancer Management Specialists-Rochester Hills Recruiting
Rochester Hills, Michigan, United States, 48309
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Michigan Cancer Specialists Active, not recruiting
Roseville, Michigan, United States, 48066
Oakland Colon and Rectal Association Active, not recruiting
Royal Oak, Michigan, United States, 48067
Cancer Care Associates PC Active, not recruiting
Royal Oak, Michigan, United States, 48073
Comprehensive Medical Center PLLC Active, not recruiting
Royal Oak, Michigan, United States, 48073
Hematology Oncology Consultants PC Active, not recruiting
Royal Oak, Michigan, United States, 48073
Oakland Medical Group Active, not recruiting
Royal Oak, Michigan, United States, 48073
William Beaumont Hospital-Royal Oak Active, not recruiting
Royal Oak, Michigan, United States, 48073
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Oncology Hematology Associates of Saginaw Valley PC Recruiting
Saginaw, Michigan, United States, 48604
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Providence Hospital-Southfield Cancer Center Recruiting
Southfield, Michigan, United States, 48075
Contact: Michael J. Kraut    248-849-5337    jaswinder.grewal@stjohn.org   
Principal Investigator: Michael J. Kraut         
Bhadresh Nayak MD PC-Sterling Heights Recruiting
Sterling Heights, Michigan, United States, 48312
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Premier Hematology Oncology Care Active, not recruiting
Sterling Heights, Michigan, United States, 48312
Mitchell Folbe MD PC Active, not recruiting
Sterling Heights, Michigan, United States, 48314
Saint Joseph Health System-Tawas City Recruiting
Tawas City, Michigan, United States, 48764
Contact: Christopher M. Reynolds    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Christopher M. Reynolds         
Michigan Institute of Urology-Town Center Active, not recruiting
Troy, Michigan, United States, 48084
Claudia BR Herke MD PC Active, not recruiting
Troy, Michigan, United States, 48085
Hematology Oncology Consultants PC-Troy Active, not recruiting
Troy, Michigan, United States, 48098
William Beaumont Hospital - Troy Active, not recruiting
Troy, Michigan, United States, 48098
Advanced Breast Care Center PLLC Recruiting
Warren, Michigan, United States, 48088
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Bhadresh Nayak MD PC-Warren Recruiting
Warren, Michigan, United States, 48093
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Great Lakes Cancer Management Specialists-Macomb Professional Building Recruiting
Warren, Michigan, United States, 48093
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Macomb Hematology Oncology PC Recruiting
Warren, Michigan, United States, 48093
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Michigan Breast Specialists-Warren Recruiting
Warren, Michigan, United States, 48093
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Mary's Oncology/Hematology Associates of West Branch Recruiting
West Branch, Michigan, United States, 48661
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Huron Gastroenterology PC Recruiting
Ypsilanti, Michigan, United States, 48106
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
IHA Hematology Oncology Consultants-Ann Arbor Recruiting
Ypsilanti, Michigan, United States, 48197
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
United States, Minnesota
Essentia Health Saint Joseph's Medical Center Recruiting
Brainerd, Minnesota, United States, 56401
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Essentia Health Cancer Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Essentia Health Saint Mary's Medical Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Miller-Dwan Hospital Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Lake Region Healthcare Corporation-Cancer Care Recruiting
Fergus Falls, Minnesota, United States, 56537
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Adams Clinic Recruiting
Hibbing, Minnesota, United States, 55746
Contact: Bret E. Friday    773-702-9171    protocols@AllianceNCTN.org   
Principal Investigator: Bret E. Friday         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Elizabeth Yan    855-776-0015      
Principal Investigator: Elizabeth Yan         
Essentia Health Virginia Clinic Recruiting
Virginia, Minnesota, United States, 55792
Contact: Bret E. Friday    844-681-7944      
Principal Investigator: Bret E. Friday         
United States, Missouri
Central Care Cancer Center - Bolivar Recruiting
Bolivar, Missouri, United States, 65613
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Siteman Cancer Center at West County Hospital Recruiting
Creve Coeur, Missouri, United States, 63141
Contact: Jian L. Campian    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Jian L. Campian         
Centerpoint Medical Center LLC Recruiting
Independence, Missouri, United States, 64057
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Luke's Hospital of Kansas City Recruiting
Kansas City, Missouri, United States, 64111
Contact: Rakesh Gaur    773-702-9171    protocols@AllianceNCTN.org   
Principal Investigator: Rakesh Gaur         
Research Medical Center Recruiting
Kansas City, Missouri, United States, 64132
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Luke's East - Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64086
Contact: Rakesh Gaur    773-702-9171    protocols@AllianceNCTN.org   
Principal Investigator: Rakesh Gaur         
Heartland Regional Medical Center Recruiting
Saint Joseph, Missouri, United States, 64507
Contact: Rakesh Gaur    816-271-7937    linda.schumacher@mymlc.com   
Principal Investigator: Rakesh Gaur         
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Jian L. Campian    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Jian L. Campian         
Siteman Cancer Center at Saint Peters Hospital Recruiting
Saint Peters, Missouri, United States, 63376
Contact: Jian L. Campian    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Jian L. Campian         
United States, Montana
Community Hospital of Anaconda Recruiting
Anaconda, Montana, United States, 59711
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Great Falls Clinic Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Saint Peter's Community Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Community Medical Hospital Recruiting
Missoula, Montana, United States, 59804
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
United States, Nevada
Carson Tahoe Regional Medical Center Recruiting
Carson City, Nevada, United States, 89703
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Cancer and Blood Specialists-Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada - Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada-Horizon Ridge Recruiting
Henderson, Nevada, United States, 89052
Contact: John A. Ellerton    702-822-2000      
Principal Investigator: John A. Ellerton         
Las Vegas Cancer Center-Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Nevada Cancer Specialists-Saint Rose Recruiting
Henderson, Nevada, United States, 89052
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
21st Century Oncology-Henderson Recruiting
Henderson, Nevada, United States, 89074
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada-Southeast Henderson Recruiting
Henderson, Nevada, United States, 89074
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Desert West Surgery Recruiting
Las Vegas, Nevada, United States, 89102
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Nevada Cancer Specialists?Oakey Recruiting
Las Vegas, Nevada, United States, 89102
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
University Medical Center of Southern Nevada Recruiting
Las Vegas, Nevada, United States, 89102
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Cancer and Blood Specialists-Shadow Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Radiation Oncology Centers of Nevada Central Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
21st Century Oncology Recruiting
Las Vegas, Nevada, United States, 89109
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Recruiting
Las Vegas, Nevada, United States, 89109
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-San Martin Recruiting
Las Vegas, Nevada, United States, 89113
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Radiation Oncology Centers of Nevada Southeast Recruiting
Las Vegas, Nevada, United States, 89119
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Cancer Therapy and Integrative Medicine Recruiting
Las Vegas, Nevada, United States, 89121
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
21st Century Oncology-Vegas Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Ann M Wierman MD LTD Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Cancer and Blood Specialists-Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada - Northwest Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Nevada Cancer Specialists-Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada-Summerlin Recruiting
Las Vegas, Nevada, United States, 89144
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Summerlin Hospital Medical Center Recruiting
Las Vegas, Nevada, United States, 89144
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Las Vegas Cancer Center-Medical Center Recruiting
Las Vegas, Nevada, United States, 89148-2405
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
21st Century Oncology-Fort Apache Recruiting
Las Vegas, Nevada, United States, 89148
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada Recruiting
Las Vegas, Nevada, United States, 89148
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Nevada Cancer Specialists-Fort Apache Recruiting
Las Vegas, Nevada, United States, 89148
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Recruiting
Las Vegas, Nevada, United States, 89149
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada - Central Valley Recruiting
Las Vegas, Nevada, United States, 89169
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
University Cancer Center Recruiting
Las Vegas, Nevada, United States, 89169
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Hope Cancer Care of Nevada-Pahrump Recruiting
Pahrump, Nevada, United States, 89048
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Renown Regional Medical Center Recruiting
Reno, Nevada, United States, 89502
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Saint Mary's Regional Medical Center Recruiting
Reno, Nevada, United States, 89503
Contact: John A. Ellerton    773-702-9171    protocols@AllianceNCTN.org   
Principal Investigator: John A. Ellerton         
Radiation Oncology Associates Recruiting
Reno, Nevada, United States, 89509
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
United States, New Hampshire
New Hampshire Oncology Hematology PA-Concord Recruiting
Concord, New Hampshire, United States, 03301
Contact: Douglas J. Weckstein    603-663-1800      
Principal Investigator: Douglas J. Weckstein         
New Hampshire Oncology Hematology PA-Hooksett Recruiting
Hooksett, New Hampshire, United States, 03106
Contact: Douglas J. Weckstein    603-663-1800      
Principal Investigator: Douglas J. Weckstein         
United States, New Jersey
Englewood Hospital and Medical Center Recruiting
Englewood, New Jersey, United States, 07631
Contact: Maxwell Janosky    201-894-3456      
Principal Investigator: Maxwell Janosky         
Overlook Hospital Recruiting
Summit, New Jersey, United States, 07902
Contact: Kurt A. Jaeckle    855-776-0015      
Principal Investigator: Kurt A. Jaeckle         
United States, New York
Roswell Park Cancer Institute Recruiting
Buffalo, New York, United States, 14263
Contact: Dheerendra Prasad    877-275-7724      
Principal Investigator: Dheerendra Prasad         
Laura and Isaac Perlmutter Cancer Center at NYU Langone Recruiting
New York, New York, United States, 10016
Contact: Andrew S. Chi    877-726-5130      
Principal Investigator: Andrew S. Chi         
United States, North Carolina
Carolinas Medical Center/Levine Cancer Institute Recruiting
Charlotte, North Carolina, United States, 28203
Contact: Ashley L. Sumrall    704-355-2884      
Principal Investigator: Ashley L. Sumrall         
Southeastern Medical Oncology Center-Clinton Recruiting
Clinton, North Carolina, United States, 28328
Contact: James N. Atkins    252-399-7491      
Principal Investigator: James N. Atkins         
Southeastern Medical Oncology Center-Goldsboro Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins    252-399-7491      
Principal Investigator: James N. Atkins         
Wayne Memorial Hospital Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins    252-399-7491      
Principal Investigator: James N. Atkins         
East Carolina University Recruiting
Greenville, North Carolina, United States, 27858
Contact: Pamela A. Lepera    252-744-2391      
Principal Investigator: Pamela A. Lepera         
Onslow Memorial Hospital Recruiting
Jacksonville, North Carolina, United States, 28546
Contact: James N. Atkins    252-399-7491      
Principal Investigator: James N. Atkins         
Southeastern Medical Oncology Center-Jacksonville Recruiting
Jacksonville, North Carolina, United States, 28546
Contact: James N. Atkins    252-399-7491      
Principal Investigator: James N. Atkins         
Southeastern Medical Oncology Center-Wilson Suspended
Wilson, North Carolina, United States, 27893
Wake Forest University Health Sciences Recruiting
Winston-Salem, North Carolina, United States, 27157
Contact: Michael D. Chan    336-713-6771      
Principal Investigator: Michael D. Chan         
United States, North Dakota
Essentia Health Cancer Center-South University Clinic Recruiting
Fargo, North Dakota, United States, 58103
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
United States, Ohio
Cleveland Clinic Akron General Active, not recruiting
Akron, Ohio, United States, 44307
Indu and Raj Soin Medical Center Active, not recruiting
Beavercreek, Ohio, United States, 45431
Dayton Physicians LLC-Miami Valley South Active, not recruiting
Centerville, Ohio, United States, 45459
Miami Valley Hospital South Active, not recruiting
Centerville, Ohio, United States, 45459
Oncology Hematology Care Inc-Kenwood Active, not recruiting
Cincinnati, Ohio, United States, 45236
Good Samaritan Hospital - Dayton Active, not recruiting
Dayton, Ohio, United States, 45406
Miami Valley Hospital Active, not recruiting
Dayton, Ohio, United States, 45409
Dayton Physicians LLC-Samaritan North Active, not recruiting
Dayton, Ohio, United States, 45415
Samaritan North Health Center Active, not recruiting
Dayton, Ohio, United States, 45415
Armes Family Cancer Center Active, not recruiting
Findlay, Ohio, United States, 45840
Blanchard Valley Hospital Active, not recruiting
Findlay, Ohio, United States, 45840
Orion Cancer Care Active, not recruiting
Findlay, Ohio, United States, 45840
Atrium Medical Center-Middletown Regional Hospital Active, not recruiting
Franklin, Ohio, United States, 45005-1066
Dayton Physicians LLC-Atrium Active, not recruiting
Franklin, Ohio, United States, 45005
Dayton Physicians LLC-Wayne Active, not recruiting
Greenville, Ohio, United States, 45331
Wayne Hospital Active, not recruiting
Greenville, Ohio, United States, 45331
Greater Dayton Cancer Center Active, not recruiting
Kettering, Ohio, United States, 45409
First Dayton Cancer Care Active, not recruiting
Kettering, Ohio, United States, 45420
Kettering Medical Center Active, not recruiting
Kettering, Ohio, United States, 45429
Dayton Physicians LLC-Signal Point Active, not recruiting
Middletown, Ohio, United States, 45042
Dayton Physicians LLC-Wilson Active, not recruiting
Sidney, Ohio, United States, 45365
Springfield Regional Cancer Center Active, not recruiting
Springfield, Ohio, United States, 45504
Springfield Regional Medical Center Active, not recruiting
Springfield, Ohio, United States, 45505
Dayton Physicians LLC-Upper Valley Active, not recruiting
Troy, Ohio, United States, 45373
Upper Valley Medical Center Active, not recruiting
Troy, Ohio, United States, 45373
United States, Oregon
Saint Alphonsus Medical Center-Baker City Recruiting
Baker City, Oregon, United States, 97814
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Saint Charles Health System Active, not recruiting
Bend, Oregon, United States, 97701
Clackamas Radiation Oncology Center Active, not recruiting
Clackamas, Oregon, United States, 97015
Providence Oncology and Hematology Care Southeast Active, not recruiting
Clackamas, Oregon, United States, 97015
Bay Area Hospital Active, not recruiting
Coos Bay, Oregon, United States, 97420
Providence Newberg Medical Center Active, not recruiting
Newberg, Oregon, United States, 97132
Saint Alphonsus Medical Center-Ontario Recruiting
Ontario, Oregon, United States, 97914
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Providence Willamette Falls Medical Center Active, not recruiting
Oregon City, Oregon, United States, 97045
Providence Portland Medical Center Active, not recruiting
Portland, Oregon, United States, 97213
Providence Saint Vincent Medical Center Active, not recruiting
Portland, Oregon, United States, 97225
United States, Pennsylvania
Lehigh Valley Hospital-Cedar Crest Recruiting
Allentown, Pennsylvania, United States, 18103
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Lehigh Valley Hospital - Muhlenberg Recruiting
Bethlehem, Pennsylvania, United States, 18017
Contact: Christopher M. Reynolds    208-367-7954      
Principal Investigator: Christopher M. Reynolds         
Christiana Care Health System-Concord Health Center Recruiting
Chadds Ford, Pennsylvania, United States, 19317
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
United States, South Carolina
Roper Hospital Active, not recruiting
Charleston, South Carolina, United States, 29401
Charleston Hematology Oncology Associates-Roper Active, not recruiting
Charleston, South Carolina, United States, 29403
Lowcountry Hematology Oncology PA-North Charleston Active, not recruiting
Charleston, South Carolina, United States, 29406
Bon Secours Saint Francis Hospital Active, not recruiting
Charleston, South Carolina, United States, 29414
Charleston Hematology Oncology Associates PA-Saint Francis Active, not recruiting
Charleston, South Carolina, United States, 29414
Lowcountry Hematology Oncology PA-West Ashley Active, not recruiting
Charleston, South Carolina, United States, 29414
Greenville Health System Cancer Institute-Laurens Recruiting
Clinton, South Carolina, United States, 29325
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Easley Recruiting
Easley, South Carolina, United States, 29640
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Butternut Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Greenville Memorial Hospital Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Eastside Recruiting
Greenville, South Carolina, United States, 29615
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Greer Recruiting
Greer, South Carolina, United States, 29650
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Lowcountry Hematology Oncology PA-Mount Pleasant Active, not recruiting
Mount Pleasant, South Carolina, United States, 29464
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: David L. Grisell    864-679-3966      
Principal Investigator: David L. Grisell         
United States, Tennessee
Vanderbilt-Ingram Cancer Center Cool Springs Recruiting
Franklin, Tennessee, United States, 37067
Contact: Albert Attia    800-811-8480      
Principal Investigator: Albert Attia         
Vanderbilt Breast Center at One Hundred Oaks Recruiting
Nashville, Tennessee, United States, 37204
Contact: Albert Attia    800-811-8480      
Principal Investigator: Albert Attia         
Vanderbilt University/Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Albert Attia    800-811-8480      
Principal Investigator: Albert Attia         
United States, Texas
M D Anderson Cancer Center Recruiting
Houston, Texas, United States, 77030
Contact: Barbara J. O'Brien    713-792-3245      
Principal Investigator: Barbara J. O'Brien         
United States, Washington
Providence Regional Cancer System-Aberdeen Active, not recruiting
Aberdeen, Washington, United States, 98520
Cancer Care Center at Island Hospital Active, not recruiting
Anacortes, Washington, United States, 98221
PeaceHealth Saint Joseph Medical Center Active, not recruiting
Bellingham, Washington, United States, 98225
Providence Regional Cancer System-Centralia Active, not recruiting
Centralia, Washington, United States, 98531
Swedish Medical Center-Edmonds Active, not recruiting
Edmonds, Washington, United States, 98026
Providence Regional Cancer Partnership Active, not recruiting
Everett, Washington, United States, 98201
Swedish Cancer Institute-Issaquah Active, not recruiting
Issaquah, Washington, United States, 98029
Kadlec Clinic Hematology and Oncology Active, not recruiting
Kennewick, Washington, United States, 99336
Providence Regional Cancer System-Lacey Active, not recruiting
Lacey, Washington, United States, 98503
PeaceHealth Saint John Medical Center Active, not recruiting
Longview, Washington, United States, 98632
Pacific Gynecology Specialists Active, not recruiting
Seattle, Washington, United States, 98104
Swedish Medical Center-Ballard Campus Active, not recruiting
Seattle, Washington, United States, 98107
Kaiser Permanente Washington Active, not recruiting
Seattle, Washington, United States, 98112
Swedish Medical Center-First Hill Active, not recruiting
Seattle, Washington, United States, 98122-4307
Swedish Medical Center-Cherry Hill Active, not recruiting
Seattle, Washington, United States, 98122-5711
Providence Regional Cancer System-Shelton Active, not recruiting
Shelton, Washington, United States, 98584
Rockwood Clinic Cancer Treatment Center-Valley Suspended
Spokane Valley, Washington, United States, 99216
Rockwood Cancer Treatment Center-DHEC-Downtown Suspended
Spokane, Washington, United States, 99204
Rockwood North Cancer Treatment Center Suspended
Spokane, Washington, United States, 99218
PeaceHealth Southwest Medical Center Active, not recruiting
Vancouver, Washington, United States, 98664
Providence Saint Mary Regional Cancer Center Active, not recruiting
Walla Walla, Washington, United States, 99362
Providence Regional Cancer System-Yelm Active, not recruiting
Yelm, Washington, United States, 98597
United States, West Virginia
United Hospital Center Recruiting
Bridgeport, West Virginia, United States, 26330
Contact: Aaron P. Provenzano    304-293-7374    cancertrialsinfo@hsc.wvu.edu   
Principal Investigator: Aaron P. Provenzano         
WVUH-East City Hospital Recruiting
Martinsburg, West Virginia, United States, 25401
Contact: Aaron P. Provenzano    304-293-7374    cancertrialsinfo@hsc.wvu.edu   
Principal Investigator: Aaron P. Provenzano         
West Virginia University Healthcare Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Aaron P. Provenzano    304-293-7374    cancertrialsinfo@hsc.wvu.edu   
Principal Investigator: Aaron P. Provenzano         
Camden-Clark Memorial Hospital Recruiting
Parkersburg, West Virginia, United States, 26101
Contact: Aaron P. Provenzano    304-293-7374    cancertrialsinfo@hsc.wvu.edu   
Principal Investigator: Aaron P. Provenzano         
United States, Wisconsin
Duluth Clinic Ashland Recruiting
Ashland, Wisconsin, United States, 54806
Contact: Bret E. Friday    773-702-9171    protocols@AllianceNCTN.org   
Principal Investigator: Bret E. Friday         
United States, Wyoming
Billings Clinic-Cody Recruiting
Cody, Wyoming, United States, 82414
Contact: Benjamin T. Marchello    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Welch Cancer Center Suspended
Sheridan, Wyoming, United States, 82801
Canada, British Columbia
BCCA-Vancouver Cancer Centre Recruiting
Vancouver, British Columbia, Canada, V5Z 4E6
Contact: Alan M. Nichol    888-939-3333      
Principal Investigator: Alan M. Nichol         
Canada, Ontario
Juravinski Cancer Centre at Hamilton Health Sciences Recruiting
Hamilton, Ontario, Canada, L8V 5C2
Contact: Jeffrey N. Greenspoon    905-387-9495      
Principal Investigator: Jeffrey N. Greenspoon         
Odette Cancer Centre- Sunnybrook Health Sciences Centre Recruiting
Toronto, Ontario, Canada, M4N 3M5
Contact: Hany Soliman    416-480-5000      
Principal Investigator: Hany Soliman         
University Health Network-Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: David B. Shultz    416-946-4501    clinical.trials@uhn.on.ca   
Principal Investigator: David B. Shultz         
Canada, Quebec
CHUM - Hopital Notre-Dame Recruiting
Montreal, Quebec, Canada, H2L 4M1
Contact: David Roberge    514-890-8000 ext 23611    sylvie.beaudoin.chum@ssss.gouv.qc.ca   
Principal Investigator: David Roberge         
CHUM - Centre Hospitalier de l'Universite de Montreal Recruiting
Montreal, Quebec, Canada, H2X 3E4
Contact: David Roberge    888-823-5923    ctsucontact@westat.com   
Principal Investigator: David Roberge         
Jewish General Hospital Suspended
Montreal, Quebec, Canada, H3T 1E2
Sponsors and Collaborators
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)
Genentech, Inc.
Investigators
Study Chair: Caroline Chung, MD M.D. Anderson Cancer Center

Responsible Party: Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier: NCT02490878     History of Changes
Obsolete Identifiers: NCT02531659
Other Study ID Numbers: A221208
NCI-2015-01348 ( Registry Identifier: NCI Clinical Trials Reporting Program )
First Posted: July 7, 2015    Key Record Dates
Last Update Posted: May 8, 2018
Last Verified: May 2018

Additional relevant MeSH terms:
Neoplasm Metastasis
Brain Neoplasms
Neoplastic Processes
Neoplasms
Pathologic Processes
Central Nervous System Neoplasms
Nervous System Neoplasms
Neoplasms by Site
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Bevacizumab
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents