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221AD302 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease (EMERGE)

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2017 by Biogen
Sponsor:
Information provided by (Responsible Party):
Biogen
ClinicalTrials.gov Identifier:
NCT02484547
First received: June 18, 2015
Last updated: March 14, 2017
Last verified: March 2017
  Purpose
The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD. Secondary objectives are to assess the effect of monthly doses of aducanumab as compared with placebo on clinical progression as measured by Mini-Mental State Examination (MMSE), AD Assessment Scale-Cognitive Subscale (13 items) [ADAS-Cog 13], and AD Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) [ADCS-ADL-MCI].

Condition Intervention Phase
Alzheimer's Disease
Drug: Aducanumab (BIIB037)
Drug: Placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Participant, Care Provider, Investigator, Outcomes Assessor
Primary Purpose: Treatment
Official Title: A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects With Early Alzheimer's Disease

Resource links provided by NLM:


Further study details as provided by Biogen:

Primary Outcome Measures:
  • Change from baseline in CDR-SB score [ Time Frame: Week 78 ]

Secondary Outcome Measures:
  • Change from baseline in MMSE score [ Time Frame: Week 78 ]
  • Change from baseline in Alzheimer's Disease Assessment Scale-Cognitive Subscale (13 items) (ADAS-Cog 13) [ Time Frame: Week 78 ]
  • Change from baseline in Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) (ADCS-ADL-MCI) score [ Time Frame: Week 78 ]

Estimated Enrollment: 1350
Study Start Date: September 2015
Estimated Study Completion Date: April 2022
Estimated Primary Completion Date: February 2020 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Low Dose
Monthly intravenous (IV) infusions
Drug: Aducanumab (BIIB037)
Low dose
Drug: Placebo
Placebo
Experimental: High Dose
Monthly intravenous (IV) infusions
Drug: Aducanumab (BIIB037)
High dose
Drug: Placebo
Placebo

  Eligibility

Ages Eligible for Study:   50 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Key Inclusion Criteria:

  • Must meet all of the following clinical criteria for MCI due to AD or mild AD and must have:
  • A Clinical Dementia Rating (CDR)-Global Score of 0.5.
  • Objective evidence of cognitive impairment at screening
  • An MMSE score between 24 and 30 (inclusive)
  • Must have a positive amyloid Positron Emission Tomography (PET) scan
  • Must consent to apolipoprotein E (ApoE) genotyping
  • If using drugs to treat symptoms related to AD, doses must be stable for at least 8 weeks prior to screening visit 1
  • Must have a reliable informant or caregiver

Key Exclusion Criteria:

  • Any medical or neurological condition (other than Alzheimer's Disease) that might be a contributing cause of the subject's cognitive impairment
  • Have had a stroke or Transient Ischemic Attack (TIA) or unexplained loss of consciousness in the past 1 year
  • Clinically significant psychiatric illness in past 6 months
  • History of unstable angina, myocardial infarction, advanced chronic heart failure, or clinically significant conduction abnormalities within 1 year prior to Screening
  • Indication of impaired renal or liver function
  • Have human immunodeficiency virus (HIV) infection
  • Have a significant systematic illness or infection in past 30 days
  • Relevant brain hemorrhage, bleeding disorder and cerebrovascular abnormalities
  • Any contraindications to brain magnetic resonance imaging (MRI) or PET scans
  • Alcohol or substance abuse in past 1 year
  • Taking blood thinners (except for aspirin at a prophylactic dose or less)

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT02484547

Contacts
Contact: Aducanumab Global Clinical Trial Center clinicaltrials@biogen.com
Contact: Aducanumab US Call Center 877-231-7271 clinicaltrials@biogen.com

  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35233
Contact    205-996-3679      
Principal Investigator: David Geldmacher         
United States, Arizona
Banner Alzheimer's Institute Recruiting
Phoenix, Arizona, United States, 85006
Contact    623-832-6500      
Principal Investigator: David Weidman         
Xenoscience Inc. Recruiting
Phoenix, Arizona, United States, 85013
Contact    602-274-9500      
Principal Investigator: Stephen Flitman         
Banner Sun Health Research Institute Recruiting
Sun City, Arizona, United States, 85351
Contact    623-832-6530      
Principal Investigator: Edward Zamrini         
United States, California
Institute for Memory Impairments Recruiting
Irvine, California, United States, 92607
Contact    949-824-3250      
Principal Investigator: Aimee Pierce         
Renewal Behavioral Health Recruiting
Long Beach, California, United States, 85013
Contact    562-426-5222      
Principal Investigator: Laja Ibraheem         
USC Keck School of Medicine Recruiting
Los Angeles, California, United States, 90033
Contact    323-442-7600      
Principal Investigator: Lon Schneider         
Hoag Memorial Hospital Presbyterian Recruiting
Newport Beach, California, United States, 92663
Contact    949-478-8858      
Principal Investigator: William Shankle         
Excell Research, Inc. Recruiting
Oceanside, California, United States, 92056
Contact    760-758-2222      
Principal Investigator: Sheryy Soefje         
Pacific Neuroscience Medical Group Recruiting
Oxnard, California, United States, 93030
Contact    805-278-4148      
Principal Investigator: James Sutton         
Anderson Clinical Research Recruiting
Redlands, California, United States, 92354
Contact    909-792-9007      
Principal Investigator: Donald Anderson         
California Research Foundation Not yet recruiting
San Diego, California, United States, 92103-6204
Pacific Research Network Recruiting
San Diego, California, United States, 92103
Contact    619-294-4302      
Principal Investigator: Stephen Thein         
University of California San Diego Medical Center Recruiting
San Diego, California, United States, 92103
Contact    619-543-6102      
Principal Investigator: James Lohr         
California Pacific Medical Center Not yet recruiting
San Francisco, California, United States, 94114
Syrentis Clinical Research Recruiting
Santa Ana, California, United States, 92705
Contact    714-542-3008      
Principal Investigator: John Duffy         
St Joseph Heritage Healthcare Recruiting
Santa Rosa, California, United States, 95403
Contact    707-521-3814      
Principal Investigator: Marc Bernstein         
Stanford University Medical Center Recruiting
Stanford, California, United States, 94305
Contact    650-725-6563      
Principal Investigator: Sharon Sha         
United States, Colorado
University Of Colorado Denver Recruiting
Aurora, Colorado, United States, 80045
Contact    303-724-7863      
Principal Investigator: Jonathan Woodcock         
IMMUNOe International Research Centers Recruiting
Thornton, Colorado, United States, 80233
Contact    303-771-9000      
Principal Investigator: Ronald Murray         
United States, Connecticut
Associated Neurologists of Southern Connecticut, PC Recruiting
Fairfield, Connecticut, United States, 06824
Contact    203-333-1151      
Principal Investigator: Dario Zagar         
Yale University School Of Medicine Recruiting
New Haven, Connecticut, United States, 06520
Contact    203-764-8100      
Principal Investigator: Christopher Van Dyck         
Research Center for Clinical Studies, Inc. Recruiting
Norwalk, Connecticut, United States, 06851
Contact    203-838-0070      
Principal Investigator: Bart Sloan         
United States, Florida
JEM Research Institute Recruiting
Atlantis, Florida, United States, 33462
Contact    561-968-2933      
Principal Investigator: Mark Goldstein         
Florida Atlantic University Recruiting
Boca Raton, Florida, United States, 33431
Contact    561-297-4806      
Principal Investigator: James Galvin         
Bradenton Research Center, Inc. Recruiting
Bradenton, Florida, United States, 34205
Contact    941-708-0005      
Principal Investigator: William McElveen         
Meridien Research Recruiting
Brooksville, Florida, United States, 34601
Contact    352-597-7578      
Principal Investigator: Kelli Max         
Quantum Laboratories Inc. Recruiting
Deerfield Beach, Florida, United States, 33064
Contact    954-786-7331      
Principal Investigator: Jose De La Gandara         
Indago Research & Health Center, Inc. Not yet recruiting
Hialeah, Florida, United States, 33012
Infinity Clinical Research, LLC Recruiting
Hollywood, Florida, United States, 33021
Contact    954-981-3850      
Principal Investigator: Harvey Schwartz         
Mayo Clinic in Florida Recruiting
Jacksonville, Florida, United States, 32224
Contact    904-953-7103      
Principal Investigator: Neill Graff-Radford         
Renstar Medical Research Recruiting
Ocala, Florida, United States, 34471
Contact    352-629-5800      
Principal Investigator: Jay Rubin         
Clinical Neuroscience Solutions, Inc. Recruiting
Orlando, Florida, United States, 32801
Contact    407-425-5100      
Principal Investigator: Linda Harper         
Axiom Clinical Research of Florida Recruiting
Tampa, Florida, United States, 33609
Contact    813-353-9613      
Principal Investigator: Susan Steen         
United States, Georgia
Emory University Cognitive Neurology Clinic & ADRC Recruiting
Atlanta, Georgia, United States, 30329
Contact    404-727-7220      
Principal Investigator: Allan Levey         
Atlanta Center for Medical Research Withdrawn
Atlanta, Georgia, United States, 30331
Medical Research Health and Education Foundation, Inc Recruiting
Columbus, Georgia, United States, 31909
Contact    706-653-8455      
Principal Investigator: Jonathan Liss         
NeuroStudies.net, LLC Recruiting
Decatur, Georgia, United States, 30033
Contact    404-475-0552      
Principal Investigator: Marshall Nash         
United States, Indiana
Josephson, Wallack, Munshower Neurology, PC Recruiting
Indianapolis, Indiana, United States, 46256
Contact    317-537-6060      
Principal Investigator: Kristi George         
United States, Kansas
Mid America Neuroscience Research Foundation Active, not recruiting
Lenexa, Kansas, United States, 66214
Heartland Research Associates, LLC Active, not recruiting
Wichita, Kansas, United States, 67207
United States, Louisiana
J. Gary Booker, MD, APMC Withdrawn
Shreveport, Louisiana, United States, 71104
United States, Massachusetts
McLean Hospital Recruiting
Belmont, Massachusetts, United States, 02478
Contact    617-855-3622      
Principal Investigator: Brent Forester         
Boston Center for Memory Recruiting
Newton, Massachusetts, United States, 05201
Contact    617-699-6927      
Principal Investigator: Paul Solomon         
United States, Mississippi
Hattiesburg Clinic, PA Recruiting
Hattiesburg, Mississippi, United States
Contact    601-268-5620      
Principal Investigator: Ronald Schwartz         
United States, Nevada
Cleveland Clinic Lou Ruvo Center for Brain Health Recruiting
Las Vegas, Nevada, United States, 89106
Contact    702-483-6026      
Principal Investigator: Charles Bernick         
United States, New Hampshire
ActivMed Practices & Research Recruiting
Portsmouth, New Hampshire, United States, 03801
United States, New Jersey
AdvanceMed Research Recruiting
Lawrenceville, New Jersey, United States, 08648
Contact    609-895-0735      
Principal Investigator: Arnold Witte         
Shua-Haim, Joshua Withdrawn
West Long, New Jersey, United States, 07764
United States, New York
Empire Neurology, PC Recruiting
Latham, New York, United States, 12110
Contact    518-785-1000      
Principal Investigator: Keith Edwards         
Weill Cornell Medical College-New York Presbyterian Hospital Recruiting
New York, New York, United States, 10021
Contact    212-746-2441      
Principal Investigator: Michael Lin         
Mount Sinai School of Medicine Recruiting
New York, New York, United States, 10029
Contact    347-326-2178      
Principal Investigator: Amy Aloysi         
United States, North Carolina
Clinical Trials of America, Inc Withdrawn
Winston-Salem, North Carolina, United States, 27103
PMG Research of Winston-Salem, LLC Recruiting
Winston-Salem, North Carolina, United States, 27103
Contact    336-794-8165      
Principal Investigator: Giles Crowell         
Wake Forest Baptist Health Recruiting
Winston-Salem, North Carolina, United States, 27103
Contact    336-713-8558      
Principal Investigator: Kaycee Sink         
United States, Ohio
University of Cincinnati Not yet recruiting
Cincinnati, Ohio, United States, 45219-0525
Contact    513-558-1141      
Principal Investigator: Rhonna Shatz         
Ohio State University Medical Center Recruiting
Dublin, Ohio, United States, 43017
Contact    614-293-8531      
Principal Investigator: Douglas Scharre         
United States, Pennsylvania
Lehigh Center for Clinical Research, LLC Recruiting
Allentown, Pennsylvania, United States, 18104
Contact    610-820-0342      
Principal Investigator: Paul Gross         
Penn Memory Center Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Grace Stockbower    215-746-3949      
Principal Investigator: David Wolk         
United States, Rhode Island
Rhode Island Hospital Recruiting
Providence, Rhode Island, United States, 02903
Contact    401-444-6440      
Principal Investigator: Brian Ott         
United States, South Carolina
Roper St. Francis Healthcare Recruiting
North Charleston, South Carolina, United States, 29406-6076
Contact    843-724-2302      
Principal Investigator: Jacobo Mintzer         
United States, Texas
Senior Adult Specialty Research Recruiting
Austin, Texas, United States, 78757
Contact    512-407-8628      
Principal Investigator: Jaron Winston         
Clinical Trial Network Recruiting
Houston, Texas, United States, 77074
Contact    713-484-6947      
Principal Investigator: Djamchid Lotfi         
United States, Utah
University of Utah Health Sciences Center Recruiting
Salt Lake City, Utah, United States, 84132
Contact    801-261-8950      
Principal Investigator: Richard King         
United States, Vermont
Clinical Neuroscience Research Association, Inc Recruiting
Bennington, Vermont, United States, 05201
Contact    802-447-1409      
Principal Investigator: Cynthia Murphy         
United States, Washington
University of Washington Medical Center Recruiting
Seattle, Washington, United States, 98195
Contact    206-221-2930      
Principal Investigator: Suman Jayadev         
Northwest Neurological, PLLC Recruiting
Spokane, Washington, United States, 99202
Contact    509-343-3710      
Principal Investigator: David Greeley         
Belgium
Imeldaziekenhuis Not yet recruiting
Bonheiden, Belgium, 2820
A.Z. Klina Not yet recruiting
Brasschaat, Belgium, 2930
Contact: Karine Geens    +32 03/6505052      
AZ Sint-Jan Brugge Recruiting
Brugge, Belgium, 8000
ULB Hôpital Erasme Withdrawn
Bruxelles, Belgium, 1070
Universitair Ziekenhuis Brussel Recruiting
Bruxelles, Belgium, 1090
Contact: Versijpt    +3224763739      
Centre Neurologique & de Réadaptation Fonctionnelle Not yet recruiting
Fraiture-en-Condroz, Belgium, 4557
Contact: Guillaume    085/519128      
Universitair Ziekenhuis Gent Not yet recruiting
Gent, Belgium, 9000
AZ Groeninge - Campus Kennedylaan Recruiting
Kortrijk, Belgium, 8500
UZ Leuven Recruiting
Leuven, Belgium, 3000
Contact: Rik Vandenberghe         
AZ Delta Recruiting
Roeselare, Belgium, 8800
Contact: Dr. Philip Bourgeois    +32 51 23 74 41      
Canada, British Columbia
Health Research. Recruiting
Kamloops, British Columbia, Canada
Health Research Recruiting
West Vancouver, British Columbia, Canada
Canada, Nova Scotia
True North Clinical Research - Halifax Inc. Not yet recruiting
Halifax, Nova Scotia, Canada, B3S 1M7
Canada, Ontario
JBN Medical Diagnostic Services Inc. Recruiting
Burlington, Ontario, Canada, L7M 4Y1
St. Joseph's HC- Parkwood Institute Recruiting
London, Ontario, Canada, N6C 5J1
Bruyere Continuing Care Recruiting
Ottawa, Ontario, Canada, K1N 5C8
Kawartha Regional Memory Clinic Recruiting
Peterborough, Ontario, Canada, K9H 2P4
Toronto Western Hospital Recruiting
Toronto, Ontario, Canada, M5T 2S8
Canada, Quebec
Recherches Neuro-Hippocampe Inc. Recruiting
Gatineau, Quebec, Canada, J8T 8J1
Recherche Sepmus, Inc. Recruiting
Greenfield Park, Quebec, Canada, J4V 2J2
DIEX Recherche Sherbrooke Inc. Recruiting
Sherbrooke, Quebec, Canada, J1H 1Z1
Douglas Hospital Research Centre Recruiting
Verdun, Quebec, Canada, H4H 1R3
Finland
Terveystalo Kamppi Not yet recruiting
Helsinki, Finland, 00100
Itä-Suomen yliopisto, Aivotutkimusyksikkö Not yet recruiting
Kuopio, Finland, 70210
Contact: Merja Hallikainen    +358405678433      
CRST, Clinical Research Services Turku Recruiting
Turku, Finland, 20520
France
Hôpital de la Timone Recruiting
Marseille, Bouches-du-Rhône, France, 13385
Contact: Ceccaldi    0033491385928      
CHU de Toulouse - Hôpital Purpan Recruiting
Toulouse cedex 9, Haute Garonne, France, 31059
Contact: Jeremie Pr Pariente    05.61.77.76.86      
Centre de Recherche Clinique du Gérontopôle - Cité de la Santé Recruiting
Toulouse, Haute Garonne, France, 31052
Contact: Vellas    +33 5 61777973      
Hôpital Gui de Chauliac Recruiting
Montpellier, Herault, France, 34295
Contact: Dr. Karim Bennys    00 33 4 67 33 79 57      
CHU Rennes - Hopital Pontchaillou Recruiting
Rennes cedex 09, Ille et Vilaine, France, 35033
CHU Nantes - Hopital Nord Laënnec Recruiting
Nantes cedex 1, Loire Atlantique, France, 44093
Hopital Roger Salengro - CHU Lille Recruiting
Lille Cedex, Nord, France, 59037
Contact: Florence Pasquier    +33 3 20 66 67 28      
Hôpital des Charpennes Recruiting
Villeurbanne, Rhone, France, 69100
Contact: Pr Krolak-Salmon    04.72.43.25.01      
Hôpital Fernand Widal Recruiting
Paris, France, 75010
Contact: Jacques Hugon         
Germany
Bezirkskrankenhaus Guenzburg Recruiting
Guenzburg, Baden Wuerttemberg, Germany, 89312
ISPG - Institut fuer Studien zur Psychischen Gesundheit Recruiting
Mannheim, Baden Wuerttemberg, Germany, 68165
Universitaetsklinikum Tuebingen Withdrawn
Tuebingen, Baden Wuerttemberg, Germany, 72076
Nervenfachaerztlichen Gemeinschaftspraxis Ulm Recruiting
Ulm, Baden Wuerttemberg, Germany, 89078
Universitaetsklinikum Ulm Recruiting
Ulm, Baden Wuerttemberg, Germany, 89081
Klinik Hohe Warte Bayreuth Not yet recruiting
Bayreuth, Bayern, Germany, 95445
Institut fuer Schlaganfall- und Demenzforschung (ISD) Recruiting
Muenchen, Bayern, Germany, 81377
Klinikum rechts der Isar der TU Muenchen Recruiting
Muenchen, Bayern, Germany, 81675
Neuropraxis Muenchen Sued Recruiting
Unterhaching, Bayern, Germany, 82008
Praxis Dr. Kluenemann Recruiting
Wenzenbach, Bayern, Germany, 93173
Neuro Centrum Odenwald Not yet recruiting
Erbach, Hessen, Germany, 64711
Schwerpunktpraxis fuer Neurologie, Psychiatrie und Klinische Studien Recruiting
Bielefeld, Nordrhein Westfalen, Germany, 33647
Universitaetsklinikum Duesseldorf AoeR Recruiting
Duesseldorf, Nordrhein Westfalen, Germany, 40629
Universitaetsklinikum Muenster Recruiting
Muenster, Nordrhein Westfalen, Germany, 48149
Zentrum f. Neurologisch- Psychiatrische Studien und Begutachtung Recruiting
Siegen, Nordrhein Westfalen, Germany, 57076
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz Not yet recruiting
Mainz, Rheinland Pfalz, Germany, 55131
Klinikum Chemnitz gGmbH Recruiting
Chemnitz, Sachsen, Germany, 09131
Kopfzentrum Leipzig Not yet recruiting
Leipzig, Sachsen, Germany, 04275
emovis GmbH Recruiting
Berlin, Germany, 10629
Neurologie im Tempelhofer Hafen Not yet recruiting
Berlin, Germany, 12099
Contact: Isabella Lemonnier    +49 30 755 123 2456      
Italy
Ospedale degli Infermi Recruiting
Ponderano, Biella, Italy, 13875
Azienda Ospedaliera Card. G. Panico Recruiting
Tricase, Lecce, Italy, 73039
ASST di Monza Recruiting
Monza, Milano, Italy, 20052
Fondazione IRCCS Istituto Neurologico Carlo Besta Recruiting
Milano, Italy, 20133
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone Recruiting
Palermo, Italy, 90100
Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia Recruiting
Perugia, Italy, 06156
Fondazione Santa Lucia IRCCS Recruiting
Roma, Italy, 00179
Umberto I Pol. di Roma-Università di Roma La Sapienza Recruiting
Roma, Italy, 00185
Japan
Research Site Recruiting
Obu-shi, Aichi-Ken, Japan, 474-8511
Research Site Recruiting
Toon-shi, Ehime-Ken, Japan, 791-0295
Research Site Not yet recruiting
Fukuoka-shi, Fukuoka-Ken, Japan, 814-0180
Research Site Not yet recruiting
Kitakyushu-Shi, Fukuoka-Ken, Japan
Research Site Recruiting
Otake-shi, Hiroshima-Ken, Japan, 739-0696
Research Site Not yet recruiting
Amagasaki-shi, Hyogo-Ken, Japan, 660-8511
Research Site Recruiting
Himeji-shi, Hyogo-Ken, Japan, 672-8043
Research Site Recruiting
Kobe-shi, Hyogo-Ken, Japan, 650-0047
Research Site Not yet recruiting
Kita-gun, Kagawa-Ken, Japan, 761-0793
Research Site Not yet recruiting
Kyoto-shi, Kyoto-Fu, Japan, 616-8255
Research Site Recruiting
Tsu-shi, Mie-Ken, Japan, 514-8507
Research Site Recruiting
Nishisonogi-gun, Nagasaki-Ken, Japan, 851-2103
Research Site Recruiting
Yufu-shi, Oita-Ken, Japan, 879-5593
Research Site Not yet recruiting
Kurashiki-shi, Okayama-Ken, Japan, 710-0813
Research Site Not yet recruiting
Okayama-shi, Okayama-Ken, Japan, 703-8265
Research Site Not yet recruiting
Tsukubo-Gun, Okayama-Ken, Japan
Research Site Recruiting
Osaka-shi, Osaka-Fu, Japan, 530-0001
Research Site Not yet recruiting
Osaka-shi, Osaka-Fu, Japan, 530-0005
Research Site Recruiting
Osaka-shi, Osaka-Fu, Japan, 545-8586
Research Site Recruiting
Osaka-shi, Osaka-Fu, Japan, 553-0003
Research Site Not yet recruiting
Sennan-shi, Osaka-Fu, Japan, 590-0503
Research Site Not yet recruiting
Suita-shi, Osaka-Fu, Japan, 565-0871
Research Site Recruiting
Toyonaka-Shi, Osaka-Fu, Japan, 560-0004
Research Site Recruiting
Hamamatsu-shi, Shizuoka-Ken, Japan, 430-8558
Research Site Withdrawn
Hamamatsu-shi, Shizuoka-Ken, Japan, 434-0041
Research Site Not yet recruiting
Shizuoka-shi, Shizuoka-Ken, Japan, 420-8688
Research Site Recruiting
Shizuoka-shi, Shizuoka-Ken, Japan, 424-8636
Netherlands
Alzheimer Research Center Recruiting
Amsterdam, Netherlands, 1081 GM
Contact: Kim Verheul    +31 20 301 71 70      
Amphia Ziekenhuis Recruiting
Breda, Netherlands, 4818 CK
Contact: Dr. A. van Norden    076 595 4127      
Kennemer Gasthuis, Zuid Recruiting
Haarlem, Netherlands, 2035 RC
Erasmus Medisch Centrum Recruiting
Rotterdam, Netherlands, 3015 CE
Poland
Podlaskie Centrum Psychogeriatrii Recruiting
Bialystok, Poland, 15-732
PALLMED Sp. z o.o. Recruiting
Bydgoszcz, Poland, 85-796
Uniwersyteckie Centrum Kliniczne Recruiting
Gdansk, Poland
Novo-Med Zielinski i wspolnicy Sp. j. Recruiting
Katowice, Poland, 40-650
Neuro-Care Site Management Organization Gabriela Klodowska-Duda Recruiting
Katowice, Poland, 40-749
Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii Klinicznej Recruiting
Krakow, Poland, 31-505
SPZOZ Centralny Szpital Kliniczny UM w Lodzi Recruiting
Lodz, Poland, 92-216
Centrum Diagnostyczno - Terapeutyczne "MEDICUS" Sp.z o.o. Recruiting
Lubin, Poland, 59-300
Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie Recruiting
Lublin, Poland, 20-950
Neurologiczny NZOZ Centrum Leczenia SM Recruiting
Plewiska, Poland, 62-064
NZOZ "NEURO-KARD", "Ilkowski i Partnerzy" Sp. Partn. Lek. Recruiting
Poznan, Poland, 61-853
Centrum Medyczne Medyk Not yet recruiting
Rzeszow, Poland, 35-055
NZOZ "SENIOR" Poradnia Psychogeriatryczna Recruiting
Sopot, Poland, 81-855
Osrodek Badan Klinicznych EUROMEDIS Recruiting
Szczecin, Poland, 70-111
mMED Maciej Czarnecki Recruiting
Warszawa, Poland, 01-697
Centralny Szpital Kliniczny MSW w Warszawie Not yet recruiting
Warszawa, Poland, 02-507
Wojewodzki Szpital Specjalistyczny we Wroclawiu Recruiting
Wroclaw, Poland, 51-124
Spain
Hospital General Universitario de Elche Recruiting
Elche, Alicante, Spain, 3203
ALTHAIA Hospital Sant Joan de Deu Recruiting
Manresa, Barcelona, Spain, 08243
Complejo Hospitalario de Caceres Recruiting
Caceres, Cáceres, Spain, 10003
Hospital Universitario Reina Sofía Recruiting
Cordoba, Córdoba, Spain, 14011
Clinica Universidad de Navarra Recruiting
Pamplona, Navarra, Spain, 31008
Contact: Mario Riverol    +34 948 255400 ext 3595      
Hospital de Basurto Recruiting
Bilbao, Vizcaya, Spain, 48013
Hospital del Mar Recruiting
Barcelona, Spain, 08003
Hospital Universitari Quiron Dexeus Recruiting
Barcelona, Spain, 08028
Hospital Universitari de Bellvitge Recruiting
Barcelona, Spain, 8907
Hospital Universitari Arnau de Vilanova Recruiting
Lleida, Spain, 25198
Hospital Universitario de La Princesa Not yet recruiting
Madrid, Spain, 28006
Hospital Universitario Virgen Macarena Recruiting
Sevilla, Spain, 41009
Sweden
Skånes Universitetssjukhus, Malmö Recruiting
Malmö, Sweden, 20502
Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus Recruiting
Mölndal, Sweden, 43141
Karolinska Universitetssjukhuset, Huddinge Recruiting
Stockholm, Sweden, 14186
Contact: Niels Andreasen    +46 858585468      
Akademiska Sjukhuset Recruiting
Uppsala, Sweden, 75185
Switzerland
Universitären Psychiatrischen Kliniken Basel (UPK) Recruiting
Basel, Switzerland, 4025
Medizinisches Zentrum MZB Biel Recruiting
Biel/Bienne, Switzerland, 2502
Hôpitaux Universitaires de Genève - HUG Recruiting
Geneve 14, Switzerland, 1211
Centre Hospitalier Universitaire Vaudois Recruiting
Lausanne, Switzerland, CH-1011
Contact: Prof. Jean-Francois Demonet    +41 21 314 97 19      
Ospedale Civico Recruiting
Lugano, Switzerland, 6903
Abteilung fuer Psychiatrische Forschung, Klinik fuer Alterspsychiatrie Recruiting
Schlieren, Switzerland, 8952
Sponsors and Collaborators
Biogen
Investigators
Study Director: Medical Director Biogen
  More Information

Additional Information:
Responsible Party: Biogen
ClinicalTrials.gov Identifier: NCT02484547     History of Changes
Other Study ID Numbers: 221AD302
2015-000967-15 ( EudraCT Number )
Study First Received: June 18, 2015
Last Updated: March 14, 2017

Keywords provided by Biogen:
Aducanumab
BIIB037

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on March 23, 2017