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A Study of Atezolizumab in Combination With Nab-Paclitaxel Compared With Placebo With Nab-Paclitaxel for Participants With Previously Untreated Metastatic Triple-Negative Breast Cancer (IMpassion130)
This study is currently recruiting participants.
Verified July 2017 by Hoffmann-La Roche
Sponsor:
Hoffmann-La Roche
Information provided by (Responsible Party):
Hoffmann-La Roche
ClinicalTrials.gov Identifier:
NCT02425891
First received: April 21, 2015
Last updated: July 7, 2017
Last verified: July 2017
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Purpose
This multicenter, randomized, double-blind study will evaluate the efficacy, safety, and pharmacokinetics of atezolizumab (MPDL3280A) administered with nab-paclitaxel compared with placebo in combination with nab-paclitaxel in participants with locally advanced or metastatic triple-negative breast cancer (TNBC) who have not received prior systemic therapy for metastatic breast cancer (mBC). The safety of single-agent nab-paclitaxel has been determined in previous studies of participants with mBC and the safety data to date suggest that atezolizumab can be safely combined with standard chemotherapy agents.
| Condition | Intervention | Phase |
|---|---|---|
| Triple Negative Breast Cancer | Drug: Atezolizumab (MPDL3280A), an engineered anti-PDL1 antibody Drug: Nab-Paclitaxel Drug: Placebo | Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Participant, Investigator Primary Purpose: Treatment |
| Official Title: | A Phase III, Multicenter, Randomized, Placebo-Controlled Study of Atezolizumab (Anti-PD-L1 Antibody) in Combination With Nab-Paclitaxel Compared With Placebo With Nab-Paclitaxel for Patients With Previously Untreated Metastatic Triple-Negative Breast Cancer |
Resource links provided by NLM:
Genetics Home Reference related topics:
breast cancer
MedlinePlus related topics:
Breast Cancer
U.S. FDA Resources
Further study details as provided by Hoffmann-La Roche:
Primary Outcome Measures:
- Progression Free Survival (PFS) According to Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1 (v1.1) in all Randomized Participants [ Time Frame: Baseline up to 53 months (assessed at Screening, every 8 weeks for the first 12 months, thereafter every 12 weeks until disease progression or death, whichever occurs first) ]
- PFS According to RECIST v1.1 in Participants with Detectable Programmed Death-Ligand 1 (PD-L1) [ Time Frame: Baseline up to 53 months (assessed at Screening, every 8 weeks for the first 12 months, thereafter every 12 weeks until disease progression or death, whichever occurs first) ]
- Overall Survival (OS) in all Randomized Participants [ Time Frame: Baseline until death due to any cause (up to 53 months) ]
- OS in Participants with Detectable PD-L1 [ Time Frame: Baseline until death due to any cause (up to 53 months) ]
Secondary Outcome Measures:
- Percentage of Participants With an Objective Response of Complete Response (CR) or Partial Response (PR) According to RECIST v1.1 in all Randomized Participants [ Time Frame: Baseline up to 53 months (assessed at Screening, every 8 weeks for the first 12 months, thereafter every 12 weeks until disease progression or death, whichever occurs first) ]
- Percentage of Participants With an Objective Response of CR or PR According to RECIST v1.1 in Participants with Detectable PD-L1 [ Time Frame: Baseline up to 53 months (assessed at Screening, every 8 weeks for the first 12 months, thereafter every 12 weeks until disease progression or death, whichever occurs first) ]
- Duration of Response (DOR) According to RECIST v1.1 in all Randomized Participants [ Time Frame: Baseline up to 53 months (assessed at Screening, every 8 weeks for the first 12 months, thereafter every 12 weeks until disease progression or death, whichever occurs first) ]
- DOR Acccording to RECIST v1.1 in Participants with Detectable PD-L1 [ Time Frame: Baseline up to 53 months (assessed at Screening, every 8 weeks for the first 12 months, thereafter every 12 weeks until disease progression or death, whichever occurs first) ]
- Time to Deterioration (TTD) in Global Health Status/Health Related Quality of Life According to European Organisation for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire Core 30 (QLQ-C30) v3.0 in all Randomized Participants [ Time Frame: Baseline up to 53 months (assessed at Day 1 of each cycle up to treatment discontinuation [approximately 53 months], every 28 days after treatment discontinuation for 1 year [overall approximately 53 months]) (cycle = 28 days) ]
- TTD in Global Health Status/Health Related Quality of Life According to EORTC QLQ-C30 v3.0 in Participants with Detectable PD-L1 [ Time Frame: Baseline up to 53 months (assessed at Day 1 of each cycle up to treatment discontinuation [approximately 53 months], every 28 days after treatment discontinuation for 1 year [overall approximately 53 months]) (cycle = 28 days) ]
- Percentage of Participants with Adverse Events (AEs) or Serious AEs (SAEs) [ Time Frame: Baseline up to 53 months ]
- Percentage of Participants with Anti-Therapeutic Antibodies (ATAs) Against Atezolizumab [ Time Frame: Baseline up to 53 months (assessed at pre-dose [Hour 0] on Day 1 of Cycles 1, 2, 3, 4, 8, 16, and every 8 cycles thereafter up to treatment discontinuation [approximately 53 months], 120 days after last dose [approximately 53 months]) (Cycle = 28 days) ]
- Maximum Serum Concentration (Cmax) for Atezolizumab [ Time Frame: Pre-dose (Hour 0) on Cycle 1 Day 1 up to 53 months (detailed timeframe is provided in outcome description section) ]Pre-dose (Hour 0), 30 minutes after end of atezolizumab infusion (infusion duration = 60 minutes) on Cycle 1 Day 1; pre-dose (Hour 0) on Day 1 of Cycles 2, 3, 4, 8, 16, and every 8 cycles thereafter up to treatment discontinuation (approximately 53 months), 120 days after last dose (approximately 53 months) (Cycle = 28 days)
- Minimum Serum Concentration (Cmin) for Atezolizumab [ Time Frame: Pre-dose (Hour 0) on Cycle 1 Day 1 up to 53 months (detailed timeframe is provided in outcome description section) ]Pre-dose (Hour 0), 30 minutes after end of atezolizumab infusion (infusion duration = 60 minutes) on Cycle 1 Day 1; pre-dose (Hour 0) on Day 1 of Cycles 2, 3, 4, 8, 16, and every 8 cycles thereafter up to treatment discontinuation (approximately 53 months), 120 days after last dose (approximately 53 months) (Cycle = 28 days)
- Plasma Concentrations of Total Paclitaxel [ Time Frame: Pre-dose (Hour 0) on Cycle 1 Day 1, pre-dose (Hour 0), 5-10 minutes before end of nab-paclitaxel infusion, 1 hour after end of nab-paclitaxel infusion (infusion duration = 30 minutes) on Cycle 3 Day 1 (Cycle = 28 days) ]
| Estimated Enrollment: | 900 |
| Actual Study Start Date: | June 23, 2015 |
| Estimated Study Completion Date: | April 30, 2020 |
| Estimated Primary Completion Date: | April 30, 2020 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: Atezolizumab Plus Nab-Paclitaxel
Participants assigned to atezolizumab plus nab-paclitaxel will receive both agents until loss of clinical benefit, unacceptable toxicity, symptomatic deterioration attributed to disease progression, or death.
|
Drug: Atezolizumab (MPDL3280A), an engineered anti-PDL1 antibody
Atezolizumab at a fixed dose of 840 milligrams via intravenous (IV) infusion on Days 1 and 15 of each 28-day cycle until loss of clinical benefit, unacceptable toxicity, symptomatic deterioration attributed to disease progression, or death.
Other Name: Tecentriq, MPDL3280A
Drug: Nab-Paclitaxel
Nab-Paclitaxel at a starting dose of 100 milligrams per square meter via IV infusion on Days 1, 8, and 15 of each 28-day cycle. Nab-Paclitaxel will be administered for a target of at least 6 cycles, with no maximum in the absence of disease progression or unacceptable toxicity.
Other Name: Abraxane®
|
|
Placebo Comparator: Placebo Plus Nab-Paclitaxel
Participants assigned to placebo plus nab-paclitaxel will receive both agents until loss of clinical benefit, unacceptable toxicity, symptomatic deterioration attributed to disease progression, or death.
|
Drug: Nab-Paclitaxel
Nab-Paclitaxel at a starting dose of 100 milligrams per square meter via IV infusion on Days 1, 8, and 15 of each 28-day cycle. Nab-Paclitaxel will be administered for a target of at least 6 cycles, with no maximum in the absence of disease progression or unacceptable toxicity.
Other Name: Abraxane®
Drug: Placebo
Placebo administered via IV infusion on Days 1 and 15 of each 28-day cycle until loss of clinical benefit, unacceptable toxicity, symptomatic deterioration attributed to disease progression, or death.
|
Eligibility| Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Metastatic or locally advanced, histologically documented TNBC characterized by absence of human epidermal growth factor 2 (HER2), estrogen receptor (ER), and progesterone receptor (PR) expression
- No prior chemotherapy or targeted systemic therapy for inoperable locally advanced or metastatic TNBC
- Eligible for taxane monotherapy (i.e., absence of rapid clinical progression, life-threatening visceral metastases, or the need for rapid symptom and/or disease control)
- A representative formalin-fixed, paraffin-embedded tumor specimen in paraffin blocks, or at least 20 unstained slides with an associated pathology report documenting ER, PR, and HER2 negativity. Participants with fewer than 20 unstained slides available at baseline, and not fewer than 12 unstained slides will be eligible upon discussion with Medical Monitor
- Eastern Cooperative Oncology Group performance status of 0 or 1
- Measurable disease as defined by RECIST v1.1
- Adequate hematologic and end-organ function
Exclusion Criteria:
- Known central nervous system (CNS) disease, except for treated asymptomatic CNS metastases
- Leptomeningeal disease
- Pregnancy or lactation
- History of autoimmune disease
- Prior allogeneic stem cell or solid organ transplantation
- Positive test for human immunodeficiency virus
- Active hepatitis B or hepatitis C
- Receipt of a live, attenuated vaccine within 4 weeks prior to randomization, during treatment, or within 5 months following the last dose of atezolizumab/placebo
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02425891
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Please refer to this study by its ClinicalTrials.gov identifier: NCT02425891
Contacts
| Contact: Reference Study ID Number: WO29522 www.roche.com/about_roche/roche_worldwide.htm | 888-662-6728 (U.S. and Canada) | global-roche-genentech-trials@gene.com |
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Locations
| United States, Alabama | |
| University of Alabama at Birmingham | Active, not recruiting |
| Birmingham, Alabama, United States, 35249 | |
| United States, Alaska | |
| Katmai Oncology | Terminated |
| Anchorage, Alaska, United States, 99508 | |
| United States, Arizona | |
| HonorHealth Research Institute - Pima Center | Terminated |
| Scottsdale, Arizona, United States, 85258 | |
| Arizona Oncology Associates, P.C. | Terminated |
| Tucson, Arizona, United States, 85710 | |
| United States, Arkansas | |
| Highlands Oncology Group | Recruiting |
| Fayetteville, Arkansas, United States, 72703 | |
| United States, California | |
| Marin Cancer Care Inc | Terminated |
| Greenbrae, California, United States, 94904 | |
| Kaiser Permanente of Northern California | Active, not recruiting |
| Oakland, California, United States, 94612 | |
| Emad Ibrahim, Md, Inc | Completed |
| Redlands, California, United States, 92373 | |
| Univ of Calif, San Francisco; Breast Cancer Center | Active, not recruiting |
| San Francisco, California, United States, 94115 | |
| Kaiser Permanente - San Marcos | Active, not recruiting |
| San Marcos, California, United States, 92069 | |
| Cancer Research Collaboration, Inc. | Active, not recruiting |
| Santa Ana, California, United States, 92705 | |
| Stanford Univ School of Med; Oncology | Active, not recruiting |
| Stanford, California, United States, 94305-5821 | |
| United States, Colorado | |
| Kaiser Permanente Of Colorado | Active, not recruiting |
| Denver, Colorado, United States, 80205 | |
| United States, Connecticut | |
| Yale Cancer Center; Medical Oncology | Active, not recruiting |
| New Haven, Connecticut, United States, 06520 | |
| Norwalk Hospital | Active, not recruiting |
| Norwalk, Connecticut, United States, 06856 | |
| Stamford Hospital; BCC, MOHR | Active, not recruiting |
| Stamford, Connecticut, United States, 06904 | |
| United States, District of Columbia | |
| MedStar Georgetown University Hospital (Lombardi Comprehensive Cancer Center) | Recruiting |
| Washington, D.C., District of Columbia, United States, 20007 | |
| United States, Florida | |
| Florida Cancer Specialists - SCRI; Pharmacy | Active, not recruiting |
| Fort Myers, Florida, United States, 33901 | |
| Mayo Clinic | Withdrawn |
| Jacksonville, Florida, United States, 32224 | |
| Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy) | Completed |
| Jacksonville, Florida, United States, 32256 | |
| The Mount Siani Comprehensive Cancer Center | Active, not recruiting |
| Miami Beach, Florida, United States, 33140 | |
| Florida Cancer Research Institute | Completed |
| Plantation, Florida, United States, 33324 | |
| Florida Cancer Specialists (St. Petersburg - St. Anthony's Professional Building) | Active, not recruiting |
| Saint Petersburg, Florida, United States, 33705 | |
| United States, Georgia | |
| Northwest Georgia Oncology Centers PC - Marietta | Active, not recruiting |
| Marietta, Georgia, United States, 30060 | |
| United States, Illinois | |
| Rush University Medical Center - Chicago | Active, not recruiting |
| Chicago, Illinois, United States, 60612 | |
| United States, Louisiana | |
| University hospitals and clinics | Terminated |
| Lafayette, Louisiana, United States, 70506 | |
| LSU Health Sciences Center | Terminated |
| New Orleans, Louisiana, United States, 70112 | |
| United States, Maryland | |
| Mercy Medical Center | Active, not recruiting |
| Baltimore, Maryland, United States, 21202 | |
| John Hopkins Sidney Kimmel Comprehensive Cancer Center | Recruiting |
| Baltimore, Maryland, United States, 21287 | |
| Maryland Oncology Hematology | Recruiting |
| Westminster, Maryland, United States, 21157 | |
| United States, Massachusetts | |
| Massachusetts General Hospital | Terminated |
| Boston, Massachusetts, United States, 02114 | |
| Beth Israel Deaconess Med Ctr; Hem/Onc | Terminated |
| Boston, Massachusetts, United States, 02215 | |
| Dana Farber Cancer Institute | Terminated |
| Boston, Massachusetts, United States, 02215 | |
| United States, Michigan | |
| Barbara Ann Karmanos Cancer Institute; Oncology | Active, not recruiting |
| Detroit, Michigan, United States, 48201 | |
| West Michigan Cancer Center | Active, not recruiting |
| Kalamazoo, Michigan, United States, 49007 | |
| United States, Mississippi | |
| Jackson Oncology Associates, PLLC | Active, not recruiting |
| Jackson, Mississippi, United States, 39202 | |
| United States, Missouri | |
| Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Division, LLC | Completed |
| Kansas City, Missouri, United States, 64132 | |
| Washington University School of Medicine | Active, not recruiting |
| Saint Louis, Missouri, United States, 63110 | |
| United States, New Hampshire | |
| New Hampshire Hematology Oncology | Active, not recruiting |
| Hooksett, New Hampshire, United States, 03106 | |
| United States, New Jersey | |
| Hackensack U Med Ctr | Terminated |
| Hackensack, New Jersey, United States, 07601 | |
| The Valley Hospital | Completed |
| Ridgewood, New Jersey, United States, 07450 | |
| United States, New Mexico | |
| San Juan Oncology Associates | Terminated |
| Farmington, New Mexico, United States, 87401 | |
| United States, New York | |
| New York Oncology Hematology, P.C. | Terminated |
| Albany, New York, United States, 12206 | |
| ProHEALTH Care Associates LLP | Active, not recruiting |
| Lake Success, New York, United States, 11042 | |
| Laura and ISAAC Perlmutter Cancer Center at NYU Langone. | Active, not recruiting |
| New York, New York, United States, 10016 | |
| Montefiore Medical Center | Active, not recruiting |
| The Bronx, New York, United States, 10467 | |
| United States, Ohio | |
| Onc/Hem Care Clin Trials LLC | Active, not recruiting |
| Cincinnati, Ohio, United States, 45242 | |
| The Mark H. Zangmeister Ctr; Mid Ohio Onc/Hem Inc. | Active, not recruiting |
| Columbus, Ohio, United States, 43219 | |
| United States, Oregon | |
| Kaiser Perm NW - Rheuma | Active, not recruiting |
| Portland, Oregon, United States, 97227 | |
| Providence Cancer Center | Active, not recruiting |
| Portland, Oregon, United States, 97231 | |
| United States, Pennsylvania | |
| St. Luke's Cancer Care Associates | Active, not recruiting |
| Bethlehem, Pennsylvania, United States, 18015 | |
| Magee Womens Hospital | Active, not recruiting |
| Pittsburgh, Pennsylvania, United States, 15213 | |
| United States, Rhode Island | |
| Women and Infants Hospital of Rhode Island | Terminated |
| Providence, Rhode Island, United States, 02906 | |
| United States, South Carolina | |
| South Carolina Oncology Associates - SCRI | Withdrawn |
| Columbia, South Carolina, United States, 29210 | |
| Greenville Health System (GHS) Cancer Institute | Recruiting |
| Greenville, South Carolina, United States, 29605 | |
| United States, Tennessee | |
| Wellmont Bristol Regional Medical Center | Active, not recruiting |
| Bristol, Tennessee, United States, 37620 | |
| West Clinic | Active, not recruiting |
| Germantown, Tennessee, United States, 38138 | |
| Tennessee Cancer Specialists | Terminated |
| Knoxville, Tennessee, United States, 37920 | |
| Sarah Cannon Cancer Center - Tennessee Oncology, Pllc | Active, not recruiting |
| Nashville, Tennessee, United States, 37203 | |
| Vanderbilt | Active, not recruiting |
| Nashville, Tennessee, United States, 37232 | |
| United States, Texas | |
| Texas Oncology- El Paso Cancer Treatment Center Gateway | Active, not recruiting |
| El Paso, Texas, United States, 79915 | |
| The Methodist Cancer Center | Completed |
| Houston, Texas, United States, 77030 | |
| University of Texas;M.D. Anderson Cancer Center | Active, not recruiting |
| Houston, Texas, United States, 77030 | |
| United States, Virginia | |
| Inova Medical Group | Recruiting |
| Fairfax, Virginia, United States, 22031 | |
| United States, Washington | |
| Cancer Care Northwest | Active, not recruiting |
| Spokane, Washington, United States, 99204 | |
| Northwest Cancer Specialists - Vancouver | Terminated |
| Vancouver, Washington, United States, 98684 | |
| Yakima Valley Memorial Hospital/North Star Lodge | Terminated |
| Yakima, Washington, United States, 98902 | |
| Argentina | |
| Centro de Oncologia e Investigacion Buenos Aires (COIBA) | Active, not recruiting |
| Buenos Aires, Argentina, B1884BBF | |
| Fundacion Investigar | Active, not recruiting |
| Caba, Argentina, C1025ABI | |
| Centro Oncologico Riojano Integral (CORI) | Active, not recruiting |
| La Rioja, Argentina, F5300COE | |
| Australia, New South Wales | |
| Chris O'Brien Lifehouse | Recruiting |
| Camperdown, New South Wales, Australia, 2050 | |
| Nepean Cancer Care Centre | Completed |
| Sydney, New South Wales, Australia, 2747 | |
| Australia, Queensland | |
| Icon Cancer Foundation | Active, not recruiting |
| South Brisbane, Queensland, Australia, 4101 | |
| Princess Alexandra Hospital; Division of Cancer Services | Recruiting |
| Woolloongabba, Queensland, Australia, 4102 | |
| Australia, Victoria | |
| Peninsula and South Eastern Haematology and Oncology Grou | Active, not recruiting |
| Frankston, Victoria, Australia, 3199 | |
| Peter MacCallum Cancer Centre; Medical Oncology | Active, not recruiting |
| Melbourne, Victoria, Australia, 3000 | |
| Sunshine Hospital | Active, not recruiting |
| St Albans, Victoria, Australia, 3021 | |
| Australia, Western Australia | |
| St John of God Hospital; Bendat Cancer Centre | Active, not recruiting |
| Subiaco, Western Australia, Australia, 6008 | |
| Austria | |
| Lkh-Univ. Klinikum Graz; Klinik Für Innere Medizin I | Active, not recruiting |
| Graz, Austria, 8036 | |
| Kh Der Barmherzigen Schwestern; Interne I X | Active, not recruiting |
| Linz, Austria, 4010 | |
| Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt. | Terminated |
| Salzburg, Austria, 5020 | |
| A.Ö. Lhk; Ii. Medizinische Abt. Mit Schwerpunkt Gaströnter. & Onkologie | Completed |
| Steyr, Austria, 4400 | |
| Medizinische Universität Wien; Univ.Klinik für Frauenheilkunde - Klinik für Gynäkologie | Terminated |
| Wien, Austria, 1090 | |
| Medizinische Universität Wien; Univ.Klinik für Innere Medizin I | Active, not recruiting |
| Wien, Austria, 1090 | |
| Belgium | |
| Institut Jules Bordet | Recruiting |
| Bruxelles, Belgium, 1000 | |
| Cliniques Universitaires St-Luc | Active, not recruiting |
| Bruxelles, Belgium, 1200 | |
| GHdC Site Notre Dame | Active, not recruiting |
| Charleroi, Belgium, 6000 | |
| AZ Groeninge (Loofstraat) | Recruiting |
| Kortrijk, Belgium, 8500 | |
| UZ Leuven Gasthuisberg | Active, not recruiting |
| Leuven, Belgium, 3000 | |
| Sint Augustinus Wilrijk | Active, not recruiting |
| Wilrijk, Belgium, 2610 | |
| Bosnia and Herzegovina | |
| University Clinical Center of the Republic of Srpska | Active, not recruiting |
| Banja Luka, Bosnia and Herzegovina, 78000 | |
| Clinic of Oncology, University Clinical Center Sarajevo | Active, not recruiting |
| Sarajevo, Bosnia and Herzegovina, 71000 | |
| Brazil | |
| Santa Casa de Misericordia de Salvador; Oncologia | Active, not recruiting |
| Salvador, BA, Brazil, 40050-410 | |
| Crio - Centro Regional Integrado de Oncologia | Active, not recruiting |
| Fortaleza, CE, Brazil, 60336-550 | |
| Hospital Araujo Jorge; Departamento de Ginecologia E Mama | Active, not recruiting |
| Goiania, GO, Brazil, 74605-070 | |
| Hospital de Caridade de Ijui; Oncologia | Active, not recruiting |
| Ijui, RS, Brazil, 98700-000 | |
| Hospital de Clinicas de Porto Alegre;Centro de Pesquisa Clinica | Active, not recruiting |
| Porto Alegre, RS, Brazil, 90035-003 | |
| Hospital Sao Lucas - PUCRS | Active, not recruiting |
| Porto Alegre, RS, Brazil, 90610-000 | |
| Centro de Pesquisas Oncologicas - CEPON | Active, not recruiting |
| Florianopolis, SC, Brazil, 88034-000 | |
| Clinica de Neoplasias Litoral | Active, not recruiting |
| Itajai, SC, Brazil, 88301-220 | |
| Hospital Perola Byington | Active, not recruiting |
| Sao Paulo, SP, Brazil, 01317-000 | |
| Hospital Sao Jose | Active, not recruiting |
| São Paulo, SP, Brazil, CEP 01321-001 | |
| Canada, Alberta | |
| Tom Baker Cancer Centre-Calgary | Active, not recruiting |
| Calgary, Alberta, Canada, T2N 4N2 | |
| Cross Cancer Institute ; Dept of Medical Oncology | Active, not recruiting |
| Edmonton, Alberta, Canada, T6G 1Z2 | |
| Canada, British Columbia | |
| Bcca - Cancer Center Southern Interior | Active, not recruiting |
| Kelowna, British Columbia, Canada, V1Y 5L3 | |
| Bcca-Fraser Valley Cancer Centre | Terminated |
| Surrey, British Columbia, Canada, V3V 1Z2 | |
| British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre | Active, not recruiting |
| Vancouver, British Columbia, Canada, V5Z 4E6 | |
| Canada, Nova Scotia | |
| QEII HSC; Oncology | Active, not recruiting |
| Halifax, Nova Scotia, Canada, B3H 2Y9 | |
| Canada, Ontario | |
| Kingston General Hospital | Active, not recruiting |
| Kingston, Ontario, Canada, K7L 2V6 | |
| Lakeridge Health Oshawa; Oncology | Active, not recruiting |
| Oshawa, Ontario, Canada, L1G 2B9 | |
| The Ottawa Hospital Cancer Centre | Active, not recruiting |
| Ottawa, Ontario, Canada, K2H 6C2 | |
| Sunnybrook Odette Cancer Centre | Active, not recruiting |
| Toronto, Ontario, Canada, M4N 3M5 | |
| Canada, Quebec | |
| McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology | Active, not recruiting |
| Montreal, Quebec, Canada, H3T 1E2 | |
| Hospital Du Saint-Sacrement | Active, not recruiting |
| Quebec City, Quebec, Canada, G1S 4L8 | |
| Chile | |
| Fundacion Arturo Lopez Perez | Terminated |
| Santiago, Chile, 7500921 | |
| Centro de Cancer Pontificie Universidad Catolica de Chile | Active, not recruiting |
| Santiago, Chile, 8330074 | |
| Centro Internacional de Estudios Clínicos (CIEC) | Terminated |
| Santiago, Chile, 8420383 | |
| Instituto Clínico Oncolo gico del Sur | Active, not recruiting |
| Temuco, Chile, 4810469 | |
| Colombia | |
| Clinica del Country | Active, not recruiting |
| Bogota, Colombia, 11001 | |
| Oncologos De Occidente, Manizales | Terminated |
| Manizales, Colombia | |
| Oncomedica S.A. | Active, not recruiting |
| Monteria, Colombia, 230002 | |
| Costa Rica | |
| Clinica CIMCA | Active, not recruiting |
| San Jose, Costa Rica, 10103 | |
| ICIMED Instituto de Investigación en Ciencias Médicas | Active, not recruiting |
| San Jose, Costa Rica, 10108 | |
| Czechia | |
| Fakultni nemocnice Olomouc; Onkologicka klinika | Active, not recruiting |
| Olomouc, Czechia, 779 00 | |
| Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika | Active, not recruiting |
| Praha 2, Czechia, 128 08 | |
| Fakultni nemocnice v Motole | Active, not recruiting |
| Praha 5, Czechia, 150 06 | |
| Denmark | |
| Herlev Hospital; Onkologisk afdeling | Terminated |
| Herlev, Denmark, 2730 | |
| Rigshospitalet, Onkologisk Klinik | Terminated |
| København Ø, Denmark, 2100 | |
| Odense Universitetshospital, Onkologisk Afdeling R | Terminated |
| Odense, Denmark, 5000 | |
| Vejle Sygehus Onkologisk Afd | Terminated |
| Vejle, Denmark, 7100 | |
| Estonia | |
| North Estonia Medical Centre Foundation; Oncology Centre | Active, not recruiting |
| Tallinn, Estonia, 13419 | |
| Tartu Uni Hospital; Hematology - Oncology Clinic | Active, not recruiting |
| Tartu, Estonia, 51014 | |
| Finland | |
| Oulu University Hospital; Oncology | Terminated |
| Oulu, Finland, 90029 | |
| KYS Sädesairaala | Terminated |
| Sädesairaala, Finland, 70210 | |
| Tampere University Hospital; Dept of Oncology | Active, not recruiting |
| Tampere, Finland, 33520 | |
| Turku Uni Central Hospital; Oncology Clinics | Terminated |
| Turku, Finland, 20520 | |
| France | |
| Ico - Paul Papin | Active, not recruiting |
| Angers, France, 49000 | |
| Institut Sainte Catherine | Recruiting |
| Avignon, France, 84918 | |
| Hopital Jean Minjoz | Recruiting |
| Besancon, France, 25030 | |
| Institut Bergonie CLCC Bordeaux | Withdrawn |
| Bordeaux, France, 33000 | |
| Centre Francois Baclesse; Comite Sein | Active, not recruiting |
| Caen, France, 14076 | |
| HOPITAL MICHALLON - CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE, Service d'oncologie Médicale | Active, not recruiting |
| Grenoble, France, 38043 | |
| Centre Oscar Lambret | Active, not recruiting |
| Lille, France, 59020 | |
| Centre Leon Berard | Recruiting |
| Lyon, France, 69008 | |
| Institut régional du Cancer Montpellier | Recruiting |
| Montpellier, France, 34298 | |
| Clinique Catherine de Sienne | Active, not recruiting |
| Nantes, France, 44202 | |
| Institut Curie | Active, not recruiting |
| Paris, France, 75005 | |
| Hopital La Pitie Salpetriere | Active, not recruiting |
| Paris, France, 75013 | |
| Institut De Cancerologie De L'Ouest; Medical Oncology | Active, not recruiting |
| Saint Herblain, France, 44115 | |
| Centre Paul Strauss | Recruiting |
| Strasbourg, France, 67085 | |
| Germany | |
| Onkologische Schwerpunktpraxis Kurfürstendamm | Terminated |
| Berlin, Germany, 10707 | |
| Ambulantes Tumorzentrum Spandau; Dres. Benno Mohr und Uwe Peters | Active, not recruiting |
| Berlin, Germany, 13581 | |
| St. Johannes Hospital; Abt. für Hämatologie und Onkologie | Active, not recruiting |
| Dortmund, Germany, 44137 | |
| Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden | Completed |
| Dresden, Germany, 01307 | |
| Universitätsklinikum Erlangen; Frauenklinik | Active, not recruiting |
| Erlangen, Germany, 91054 | |
| Uniklinik Essen; Gynäkologie | Completed |
| Essen, Germany, 45122 | |
| Niels-Stensen-Kliniken Franziskus-Hospital Harderberg GmbH | Active, not recruiting |
| Georgsmarienhütte, Germany, 49124 | |
| Universitätsklinikum Halle (Saale); Universitätsklinik Und Poliklinik Für Gynäkologie | Active, not recruiting |
| Halle, Germany, 06120 | |
| Universitätsklinikum Hamburg-Eppendorf; Frauenklinik | Active, not recruiting |
| Hamburg, Germany, 20246 | |
| Facharztzentrum Eppendorf, Studien GbR | Active, not recruiting |
| Hamburg, Germany, 20249 | |
| Gynaekologisch-Onkologische Schwerpunktpraxis Prof. Dr. med. Lueck, Dr. Schrader und Dr. Noeding | Terminated |
| Hannover, Germany, 30177 | |
| Universitatsklinik Heidelberg; Universitätshautklinik und Nationales Centrum für Tumorerkrankungen | Active, not recruiting |
| Heidelberg, Germany, 69120 | |
| Praxis Köppler, Heymann, Weide, Thomalla; Fä Für Innere Medizin | Active, not recruiting |
| Koblenz, Germany, 56068 | |
| St. Elisabeth-Krankenhaus; Brustzentrum | Active, not recruiting |
| Köln, Germany, 50935 | |
| Universitätsklinikum Schleswig-Holstein; Campus Lübeck | Active, not recruiting |
| Lübeck, Germany, 23538 | |
| Klinikum Magdeburg gemeinnützige GmbH; Klinik Haematologie und Onkologie | Terminated |
| Magdeburg, Germany, 39130 | |
| Klinikum rechts der Isar der TU München; Frauenklinik & Poliklinik | Active, not recruiting |
| München, Germany, 81675 | |
| Gemeinschaftspraxis für Hämatologie und Onkologie | Active, not recruiting |
| Münster, Germany, 48149 | |
| MVZ Nordhausen gGmbH, Praxis Dr. Grafe | Completed |
| Nordhausen, Germany, 99734 | |
| Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe | Withdrawn |
| Offenbach, Germany, 63069 | |
| Oncologianova GmbH - Gesellschaft für Innovationen in der Onkologie | Active, not recruiting |
| Recklinghausen, Germany, 45657 | |
| Universitätsfrauen- und Poliklinik am Klinikum Suedstadt | Active, not recruiting |
| Rostock, Germany, 18059 | |
| Mutterhaus der Borromäerinnen gGmbH, Abteilung Hämatologie-Onkologie | Active, not recruiting |
| Trier, Germany, 54219 | |
| Dres. Helmut Forstbauer, Carsten Ziske und Kollegen; Onkologische Schwerpunktpraxis | Active, not recruiting |
| Troisdorf, Germany, 53840 | |
| Universitätsklinik Tübingen; Frauenklinik & Poliklinik | Active, not recruiting |
| Tübingen, Germany, 72076 | |
| Greece | |
| Anticancer Hospital Ag Savas; 1St Dept of Internal Medicine | Recruiting |
| Athens, Greece, 115 22 | |
| IASO General Hospital of Athens | Recruiting |
| Athens, Greece, 155 62 | |
| Univ General Hosp Heraklion; Medical Oncology | Recruiting |
| Heraklion, Greece, 711 10 | |
| University Hospital of Patras Medical Oncology | Recruiting |
| Patras, Greece, 265 04 | |
| Euromedical General Clinic of Thessaloniki; Oncology Department | Recruiting |
| Thessaloniki, Greece, 546 45 | |
| Guatemala | |
| Grupo Angeles | Active, not recruiting |
| Guatemala City, Guatemala, 01015 | |
| Hong Kong | |
| Queen Elizabeth Hospital; Clinical Oncology | Active, not recruiting |
| Hong Kong, Hong Kong | |
| Queen Mary Hospital; Dept of Medicine | Active, not recruiting |
| Hong Kong, Hong Kong | |
| Tuen Mun Hospital; Clinical Oncology | Active, not recruiting |
| Hong Kong, Hong Kong | |
| Hungary | |
| Semmelweis Egyetem Onkologiai Központ | Terminated |
| Budapest, Hungary, 1083 | |
| Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly | Active, not recruiting |
| Budapest, Hungary, 1122 | |
| Fövárosi Önkormányzat uzsoki utcai Kórház | Active, not recruiting |
| Budapest, Hungary, 1145 | |
| Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ | Active, not recruiting |
| Szeged, Hungary, 6720 | |
| Italy | |
| A.O. Universitaria Federico II Di Napoli; Oncologia Ed Endocrinologia Clinica | Withdrawn |
| Napoli, Campania, Italy, 80131 | |
| Istituto Nazionale Tumori Irccs Fondazione g. PASCALE;U.O.C. Oncologia Medica Senologica | Active, not recruiting |
| Napoli, Campania, Italy, 80131 | |
| Policlinico Universitario Campus Biomedico; Uoc Oncologia Medica | Withdrawn |
| Roma, Lazio, Italy, 00128 | |
| Asst Papa Giovanni XXIII; Oncologia Medica | Terminated |
| Bergamo, Lombardia, Italy, 24128 | |
| Irccs Ospedale San Raffaele;Oncologia Medica | Terminated |
| Milano, Lombardia, Italy, 20132 | |
| Irccs Istituto Europeo Di Oncologia (IEO); Ricerca Di Senologia Medica | Active, not recruiting |
| Milano, Lombardia, Italy, 20141 | |
| Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia | Withdrawn |
| Rozzano, Lombardia, Italy, 20089 | |
| Ospedale Vito Fazzi; Div. Oncoematologia | Terminated |
| Lecce, Puglia, Italy, 73100 | |
| Ospedale Della Misericordia; U.O. Di Medicina Ia - Oncologia Medica | Terminated |
| Grosseto, Toscana, Italy, 58100 | |
| IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda | Withdrawn |
| Padova, Veneto, Italy, 35128 | |
| Japan | |
| Aichi Cancer Center Hospital | Active, not recruiting |
| Aichi, Japan, 464-8681 | |
| National Hospital Organization Shikoku Cancer Center | Active, not recruiting |
| Ehime, Japan, 791-0280 | |
| Fukushima Medical University Hospital | Active, not recruiting |
| Fukushima, Japan, 960-1295 | |
| Gunma Prefectural Cancer Center | Active, not recruiting |
| Gunma, Japan, 373-8550 | |
| Hiroshima City Hiroshima Citizens Hospital | Active, not recruiting |
| Hiroshima, Japan, 730-8518 | |
| Hiroshima University Hospital | Active, not recruiting |
| Hiroshima, Japan, 734-8551 | |
| National Hospital Organization Hokkaido Cancer Center | Active, not recruiting |
| Hokkaido, Japan, 003-0804 | |
| Hyogo College of Medicine Hospital | Active, not recruiting |
| Hyogo, Japan, 663-8501 | |
| Tokai University Hospital | Active, not recruiting |
| Isehara-shi, Japan, 259-1193 | |
| Sagara Hospital | Active, not recruiting |
| Kagoshima, Japan, 892-0833 | |
| St. Marianna University School of Medicine Hospital | Active, not recruiting |
| Kanagawa, Japan, 216-8511 | |
| Kumamoto University Hospital | Active, not recruiting |
| Kumamoto, Japan, 860-8556 | |
| Kyoto University Hospital | Active, not recruiting |
| Kyoto, Japan, 606-8507 | |
| Mie University Hospital | Active, not recruiting |
| Mie, Japan, 514-8507 | |
| Tohoku University Hospital | Active, not recruiting |
| Miyagi, Japan, 980-8574 | |
| Niigata Cancer Center Hospital | Active, not recruiting |
| Niigata-shi, Japan, 951-8566 | |
| Okayama University Hospital | Active, not recruiting |
| Okayama, Japan, 700-8558 | |
| Naha-nishi Clinic | Active, not recruiting |
| Okinawa, Japan, 901-0154 | |
| National Hospital Organization Osaka National Hospital | Active, not recruiting |
| Osaka, Japan, 540-0006 | |
| Osaka International Cancer Institute | Active, not recruiting |
| Osaka, Japan, 541-8567 | |
| Kindai University Hospital | Active, not recruiting |
| Osaka, Japan, 589-8511 | |
| Saitama Medical University International Medical Center | Active, not recruiting |
| Saitama, Japan, 350-1298 | |
| Saitama Cancer Center | Recruiting |
| Saitama, Japan, 362-0806 | |
| Shizuoka General Hospital | Active, not recruiting |
| Shizuoka-shi, Japan, 420-8527 | |
| Shizuoka Cancer Center | Active, not recruiting |
| Shizuoka, Japan, 411-8777 | |
| National Cancer Center Hospital | Active, not recruiting |
| Tokyo, Japan, 104-0045 | |
| St. Luke's International Hospital | Active, not recruiting |
| Tokyo, Japan, 104-8560 | |
| Toranomon Hospital | Active, not recruiting |
| Tokyo, Japan, 105-8470 | |
| Komagome Hospital | Active, not recruiting |
| Tokyo, Japan, 113-8677 | |
| The Cancer Institute Hospital of JFCR | Active, not recruiting |
| Tokyo, Japan, 135-8550 | |
| Korea, Republic of | |
| National Cancer Center | Recruiting |
| Gyeonggi-do, Korea, Republic of, 10408 | |
| Seoul National University Hospital | Recruiting |
| Seoul, Korea, Republic of, 03080 | |
| Severance Hospital, Yonsei University Health System | Active, not recruiting |
| Seoul, Korea, Republic of, 03722 | |
| Asan Medical Center | Active, not recruiting |
| Seoul, Korea, Republic of, 05505 | |
| Samsung Medical Center | Active, not recruiting |
| Seoul, Korea, Republic of, 06351 | |
| Latvia | |
| Daugavpils Regional Hospital | Active, not recruiting |
| Daugavpils, Latvia, 5417 | |
| Riga East Clinical University Hospital Latvian Oncology Centre | Active, not recruiting |
| Riga, Latvia, LV-1079 | |
| Mexico | |
| Centro Médico Zambrano Hellion | Active, not recruiting |
| Monterrey, Nuevo Leon, Mexico, 66278 | |
| Instituto Estatal de Cancerologia Colima | Active, not recruiting |
| Colima, Mexico, 28000 | |
| Iem-Fucam | Active, not recruiting |
| D.f., Mexico, 04980 | |
| Centro Medico Dalinde | Active, not recruiting |
| D.f., Mexico, 06760 | |
| Consultorio de Medicina Especializada; Dentro de Condominio San Francisco | Active, not recruiting |
| Mexico City, Mexico, 03100 | |
| Norway | |
| Helse Bergen HF Haukeland universitetssjukehus kreftavdelingen poliklinikk | Active, not recruiting |
| Bergen, Norway | |
| Sørlandet Sykehus Kristiansand | Active, not recruiting |
| Kristiansand, Norway, 4604 | |
| Stavanger Universitetssykehus, Helse Stavanger HF | Active, not recruiting |
| Stavanger, Norway, 4011 | |
| Panama | |
| Centro Oncológico de Panamá | Active, not recruiting |
| Panama, Panama, 082400133 | |
| Poland | |
| Centrum Onkologii w Bydgoszczy; Oddzial Kliniczny Onkologii | Active, not recruiting |
| Bydgoszcz, Poland, 85-796 | |
| Szpitale Wojewodzkie w Gdyni Sp. z o.o. | Completed |
| Gdynia, Poland, 81-519 | |
| Przychodnia Lekarska KOMED | Active, not recruiting |
| Konin, Poland, 62-500 | |
| Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii | Active, not recruiting |
| Krakow, Poland, 31-531 | |
| Centrum Onkologii Ziemi LUBELSKIEJ im. Sw Jana z Dukli, I oddz. Chemioterapii | Completed |
| Lublin, Poland, 20-090 | |
| Cent.Onkologii-Instytut im. M. S-Curie, Klinika Now. Piersi i Chirurgii Rekon | Active, not recruiting |
| Warszawa, Poland, 02-781 | |
| Wojskowy Instytut Medyczny | Completed |
| Warszawa, Poland, 04-141 | |
| Mazowiecki Szpital Onkologiczny | Terminated |
| Wieliszew, Poland, 05-135 | |
| Portugal | |
| Hospital de Braga; Servico de Oncologia Medica X | Withdrawn |
| Braga, Portugal, 4710-243 | |
| IPO de Lisboa; Servico de Oncologia Medica | Withdrawn |
| Lisboa, Portugal, 1099-023 | |
| Hospital de Santa Maria; Servico de Oncologia Medica | Withdrawn |
| Lisboa, Portugal, 1649-035 | |
| IPO do Porto; Servico de Oncologia Medica | Withdrawn |
| Porto, Portugal, 4200-072 | |
| Romania | |
| Prof. Dr. I. Chiricuta Institute of Oncology | Withdrawn |
| Cluj Napoca, Romania, 400015 | |
| Euroclinic Center of Oncology SRL | Active, not recruiting |
| Iasi, Romania, 700106 | |
| Oncomed SRL | Active, not recruiting |
| Timisoara, Romania, 300239 | |
| Russian Federation | |
| Moscow City Oncology Hospital #62 | Active, not recruiting |
| Moscovskaya Oblast, Moskovskaja Oblast, Russian Federation, 143423 | |
| Arkhangelsk Regional Clinical Oncology Dispensary | Active, not recruiting |
| Arkhangelsk, Russian Federation, 163045 | |
| Ivanovo Regional Oncology Dispensary | Recruiting |
| Ivanovo, Russian Federation, 153040 | |
| Clinical Oncology Dispensary of Ministry of Health of Tatarstan | Active, not recruiting |
| Kazan, Russian Federation, 420029 | |
| Main Military Clinical Hospital named after N.N. Burdenko | Recruiting |
| Moscow, Russian Federation, 105229 | |
| Blokhin Cancer Research Center; Combined Treatment | Active, not recruiting |
| Moscow, Russian Federation, 115478 | |
| S-Pb clinical scientific practical center of specialized kinds of medical care (oncological) | Active, not recruiting |
| Saint-Petersburg, Russian Federation, 197758 | |
| Samara Regional Oncology Dispensary | Withdrawn |
| Samara, Russian Federation, 443031 | |
| Serbia | |
| Institute for Onc/Rad Serbia | Terminated |
| Belgrade, Serbia, 11000 | |
| Clinical Center Bezanijska Kosa | Active, not recruiting |
| Belgrade, Serbia, 11070 | |
| Institute for oncology of Vojvodina | Terminated |
| Sremska Kamenica, Serbia, 21204 | |
| Singapore | |
| National University Hospital | Active, not recruiting |
| Singapore, Singapore, 119074 | |
| National Cancer Centre | Active, not recruiting |
| Singapore, Singapore, 169610 | |
| Slovenia | |
| Institute of Oncology Ljubljana | Active, not recruiting |
| Ljubljana, Slovenia, 1000 | |
| Spain | |
| Hospital de Donostia; Servicio de Oncologia Medica | Active, not recruiting |
| San Sebastian, Guipuzcoa, Spain, 20080 | |
| Hospital del Mar; Servicio de Oncologia | Active, not recruiting |
| Barcelona, Spain, 08003 | |
| Hospital Univ Vall d'Hebron; Servicio de Oncologia | Recruiting |
| Barcelona, Spain, 08035 | |
| Hospital Duran i Reynals; Oncologia | Recruiting |
| Barcelona, Spain, 08907 | |
| Hospital Universitario Reina Sofia; Servicio de Oncologia | Active, not recruiting |
| Cordoba, Spain, 14004 | |
| Hospital Universitario 12 de Octubre; Servicio de Oncologia | Recruiting |
| Madrid, Spain, 28041 | |
| Hospital Universitario La Paz; Servicio de Oncologia | Active, not recruiting |
| Madrid, Spain, 28046 | |
| Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia | Recruiting |
| Malaga, Spain, 29010 | |
| Instituto Valenciano Oncologia; Oncologia Medica | Recruiting |
| Valencia, Spain, 46009 | |
| Sweden | |
| Skånes Universitetssjukhus; Kliniska Forskningsenheten Onkologimottagning medicinsk behandling | Terminated |
| Malmö, Sweden, 205 02 | |
| Sodersjukhuset; Onkologkliniken | Active, not recruiting |
| Stockholm, Sweden, 118 83 | |
| Akademiska sjukhuset, Onkologkliniken | Active, not recruiting |
| Uppsala, Sweden, 75185 | |
| Universitetssjukhuset Örebro, Onkologiska kliniken | Terminated |
| Örebro, Sweden, 701 85 | |
| Switzerland | |
| Universitaetsspital Basel; Onkologie | Completed |
| Basel, Switzerland, 4031 | |
| Kantonsspital Graubünden;Onkologie und Hämatologie | Terminated |
| Chur, Switzerland, 7000 | |
| Kantonsspital St. Gallen; Brustzentrum | Active, not recruiting |
| St. Gallen, Switzerland, 9007 | |
| OnkoZentrum Zuerich | Active, not recruiting |
| Zürich, Switzerland, 8038 | |
| Taiwan | |
| Kaohsiung Medical Uni Chung-Ho Hospital; Dept of Surgery | Active, not recruiting |
| Kaohsiung, Taiwan, 807 | |
| China Medical University Hospital; Surgery | Recruiting |
| Taichung, Taiwan, 404 | |
| VETERANS GENERAL HOSPITAL; Department of General Surgery | Active, not recruiting |
| Taipei, Taiwan, 00112 | |
| National Taiwan Uni Hospital; General Surgery | Completed |
| Taipei, Taiwan, 100 | |
| Thailand | |
| Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc | Active, not recruiting |
| Bangkok, Thailand, 10400 | |
| Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology | Active, not recruiting |
| Bangkok, Thailand, 10700 | |
| Prince of Songkla Uni ; Unit of Medical Oncology | Active, not recruiting |
| Songkhla, Thailand, 90110 | |
| Turkey | |
| Cukurova Uni Faculty of Medicine; Medical Oncology | Recruiting |
| Adana, Turkey, 01330 | |
| Istanbul University Cerrahpasa Medical Faculty; Radiation Oncology Department | Recruiting |
| Istanbul, Turkey, 34098 | |
| Medipol University Medical Faculty; Oncology Department | Active, not recruiting |
| Istanbul, Turkey, 34214 | |
| Ege Uni Medical Faculty Hospital; Oncology Dept | Recruiting |
| Izmir, Turkey, 35100 | |
| Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department | Terminated |
| Malatya, Turkey, 44280 | |
| Hacettepe Uni Medical Faculty Hospital; Oncology Dept | Recruiting |
| Sıhhiye, ANKARA, Turkey, 06100 | |
| Ukraine | |
| CI Dnipropetrovsk CMCH 4 of Dnipropetrovsk RC Dept of Chemotherapy SI Dnipropetrovsk MA of MOHU | Active, not recruiting |
| Dnipropetrovsk, Ukraine, 49102 | |
| Kyiv City Clinical Oncological Center | Active, not recruiting |
| Kyiv, Ukraine, 03115 | |
| Treatment and Prevention Institution Volyn Regional Oncology Dispensary | Active, not recruiting |
| Lutsk, Ukraine, 43018 | |
| Lviv State Oncology Regional Treatment and Diagnostic Centre | Active, not recruiting |
| Lviv, Ukraine, 79031 | |
| United Kingdom | |
| Velindre Cancer Centre | Active, not recruiting |
| Cardiff, United Kingdom, CF14 2TL | |
| Western General Hospital; Clinical Oncology | Active, not recruiting |
| Edinburgh, United Kingdom, EH4 2XU | |
| St Bartholomew's Hospital | Active, not recruiting |
| London, United Kingdom, EC1A 7BE | |
| Guys ST Thomas Hospital | Active, not recruiting |
| London, United Kingdom, SE1 9RT | |
| Royal Marsden Hospital | Active, not recruiting |
| London, United Kingdom, SW3 6JJ | |
| Christie Hospital Nhs Trust; Medical Oncology | Active, not recruiting |
| Manchester, United Kingdom, M2O 4BX | |
| Nottingham University Hospitals NHS Trust | Withdrawn |
| Nottingham, United Kingdom, NG7 2UH | |
| Derriford Hospital | Active, not recruiting |
| Plymouth, United Kingdom, PL6 8DH | |
| Royal Preston Hosptial | Active, not recruiting |
| Preston, United Kingdom, PR2 9HT | |
| Weston Park Hospital | Recruiting |
| Sheffield, United Kingdom, S10 2SJ | |
| Royal Marsden Hospital; Dept of Medical Oncology | Completed |
| Sutton, United Kingdom, SM2 5PT | |
Sponsors and Collaborators
Hoffmann-La Roche
Investigators
| Study Director: | Clinical Trials | Hoffmann-La Roche |
More Information
| Responsible Party: | Hoffmann-La Roche |
| ClinicalTrials.gov Identifier: | NCT02425891 History of Changes |
| Other Study ID Numbers: |
WO29522 2014-005490-37 ( EudraCT Number ) |
| Study First Received: | April 21, 2015 |
| Last Updated: | July 7, 2017 |
Additional relevant MeSH terms:
|
Breast Neoplasms Triple Negative Breast Neoplasms Neoplasms by Site Neoplasms Breast Diseases Skin Diseases Paclitaxel Albumin-Bound Paclitaxel Antibodies Immunoglobulins |
Antibodies, Monoclonal Antineoplastic Agents, Phytogenic Antineoplastic Agents Tubulin Modulators Antimitotic Agents Mitosis Modulators Molecular Mechanisms of Pharmacological Action Immunologic Factors Physiological Effects of Drugs |
ClinicalTrials.gov processed this record on July 14, 2017