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The Effect Of Aspirin On Survival in in Patients Undergoing Chronic Hemodialysis

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ClinicalTrials.gov Identifier: NCT02261025
Recruitment Status : Completed
First Posted : October 9, 2014
Last Update Posted : October 23, 2014
Sponsor:
Information provided by (Responsible Party):
Hui Min Jin, Shanghai Jiao Tong University School of Medicine

Study Description
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Brief Summary:
The aim of present study is to examine the effect of low-dose aspirin on the incidence of cardiovascular events and mortality in patients undergoing chronic hemodialysis.

Condition or disease Intervention/treatment Phase
Hemodialysis Drug: acetylsalicylic acid Not Applicable

Detailed Description:
This study prospectively evaluate the impacts of low dose aspirin on survival and cardio-cerebral vascular events in a large cohort of Chinese patients undergoing chronic hemodialysis. Between January 2008, consecutive patients with hemodialysis with aspirin were enrolled.We examine the association of aspirin with all-cause mortality in patients matched by propensity scores using the Kaplan-Meier method and Cox models in "intention-to-treat" analyses.The secondary endpoint was rate of cardio-cerebral events.
Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 410 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: The Effect Of Aspirin On Survival in in Patients Undergoing Chronic Hemodialysis
Study Start Date : January 2008
Actual Primary Completion Date : September 2014
Actual Study Completion Date : September 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Dialysis
Drug Information available for: Aspirin

Arms and Interventions
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Arm Intervention/treatment
Experimental: Aspirin group
Aspirin 75-100mg,per day，oral
 Drug: acetylsalicylic acid
75-100mg,per day
Other Name: Aspirin
No Intervention: non-aspirin group
No interventions


Outcome Measures
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Primary Outcome Measures :
  1. survival rate [ Time Frame: 5 years ]

Secondary Outcome Measures :
  1. cardio-cerebral event [ Time Frame: 5 years ]

Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

All patients aged 18 to 85, undergoing chronic hemodialysis, who have none of the following exclusion criteria.

Exclusion Criteria:

History of gastric or duodenal ulcers Known allergy to aspirin or other NSAIDs

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Contacts and Locations
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No Contacts or Locations Provided
More Information
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Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Hui Min Jin, Shanghai Jiao Tong University School of Medicine
ClinicalTrials.gov Identifier: NCT02261025    
Other Study ID Numbers: 20120308
First Posted: October 9, 2014    Key Record Dates
Last Update Posted: October 23, 2014
Last Verified: October 2014
Keywords provided by Hui Min Jin, Shanghai Jiao Tong University School of Medicine:
aspirin
Additional relevant MeSH terms:
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Aspirin
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
 Antirheumatic Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Platelet Aggregation Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Antipyretics