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Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

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ClinicalTrials.gov Identifier: NCT02239120
Recruitment Status : Completed
First Posted : September 12, 2014
Last Update Posted : September 3, 2018
Sponsor:
Information provided by (Responsible Party):
Boehringer Ingelheim

Brief Summary:
This trial will enroll approximately 6,000 patients with recent embolic stroke of unknown source (ESUS). Patients will be randomized to dabigatran or acetylsalicyclic acid (ASA) (1:1 ratio) and have visits every three months. The study doctor may prescribe blinded concomitant ASA for pts with coronary artery disease but this is not mandatory. All Adverse Events (AEs), Serious Adverse Events (SAEs), outcome events will be recorded. The trial will conclude when the required number of stroke events are positively adjudicated which is estimated to take 3 years (including 2.5 years of enrollment).

Condition or disease Intervention/treatment Phase
Stroke Secondary Prevention Drug: optional ASA as comedication Drug: placebo to ASA Drug: placebo to optional ASA as comedication Drug: placebo to dabigatran etexilate Drug: ASA 100 mg Drug: dabigatran etexilate Phase 3

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 5390 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Official Title: Randomized, Double-blind, Evaluation in Secondary Stroke Prevention Comparing the EfficaCy and Safety of the Oral Thrombin Inhibitor Dabigatran Etexilate (110 mg or 150 mg, Oral b.i.d.) Versus Acetylsalicylic Acid (100 mg Oral q.d.) in Patients With Embolic Stroke of Undetermined Source (RESPECT ESUS)
Actual Study Start Date : November 27, 2014
Actual Primary Completion Date : August 14, 2018
Actual Study Completion Date : August 14, 2018

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: dabigatran etexilate 110 or 150 mg
Patients will be assigned Dabigatran 150 mg b.i.d. (unless they are 75 years or older, or have a Creatinine Clearance (CrCl) of greater than or equal to 30 to less than 50ml/min (or experience GI bleed during trial), in which case they will receive Dabigatran 110 mg b.i.d.). All patients in this arm will also receive ASA placebo (q.d.)
Drug: optional ASA as comedication
optional concomitant treatment which can be used for patients with coronary artery disease. It is not required for these pts.

Drug: placebo to ASA
placebo to comparator drug

Drug: dabigatran etexilate
active drug

Active Comparator: ASA 100 mg
All patients will receive blinded ASA 100 mg q.d. and dabigatran placebo 150 mg b.i.d. (unless they are 75 years or older, or have a CrCl of greater than or equal to 30 to less than 50ml/min (or experience GI bleed during trial), in which case they will receive placebo Dabigatran 110 mg b.i.d
Drug: placebo to optional ASA as comedication
optional concomitant treatment which can be used for patients with coronary artery disease. It is not required for these pts.

Drug: placebo to dabigatran etexilate
placebo

Drug: ASA 100 mg
active comparator drug




Primary Outcome Measures :
  1. Time to first recurrent stroke (ischemic, hemorrhagic, or unspecified) [ Time Frame: up to 36 months ]

Secondary Outcome Measures :
  1. Time to Ischemic Stroke [ Time Frame: up to 36 months ]
  2. Composite endpoint of (time to) nonfatal stroke, nonfatal myocardial infarction (MI) and cardiovascular death [ Time Frame: up to 36 months ]
  3. Time to Disabling stroke (modified Rankin Scale greater than or equal to 4, as determined 3 months after recurrent stroke) [ Time Frame: up to 36 months ]
  4. Time to All-cause death [ Time Frame: up to 36 months ]
  5. Time to first major bleed [ Time Frame: up to 36 months ]
  6. Time to first intracranial hemorrhage [ Time Frame: up to 36 months ]
  7. Time to life-threatening bleed [ Time Frame: up to 36 months ]
  8. Fatal bleed [ Time Frame: up to 36 months ]
  9. Time to any bleed (all severities) [ Time Frame: up to 36 months ]


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Ages Eligible for Study:   18 Years to 150 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion criteria:

  • Ischemic stroke with a brain lesion visualized by neuroimaging (either brain Computed Tomography (CT) or Magnetic Resonance Image (MRI)). The visualized stroke is a non-lacunar infarct , e.g. involving the cortex or >1.5 cm (>2.0 cm if measured on MRI diffusion-weighted images) in largest diameter if exclusively subcortical.Visualization by CT usually requires delayed imaging >24-48 hours after stroke onset.
  • The index stroke must have occurred either up to 3 months before randomization (Modified Rankin Scale(mRS) <=3 at randomization) or up to 6 months before randomization (mRS <=3 at randomization) in selected patients that are >= 60 years plus at least one additional risk factor for recurrent stroke.
  • Arterial imaging or cervical plus TCD ultrasonography does not show extra-cranial or intracranial atherosclerosis with >= 50% luminal stenosis in artery supplying the area of acute ischemia.
  • As evidenced by cardiac monitoring for >= 20 hours with automated rhythm detection, there is absence of AF > 6 minutes in duration (within a 20 hour period, either as single episode or cumulative time of multiple episodes).

Further inclusion criteria apply.

Exclusion criteria:

  • Modified Rankin Scale of >=4 at time of randomization or inability to swallow medications.
  • Major risk cardioembolic source of embolism such as: a) intracardiac thrombus as evidenced by transthoracic or transesophageal echocardiography, b) paroxysmal, persistent or permanent AF, c) atrial flutter, d) prosthetic cardiac valve (mitral or aortic, bioprosthetic or mechanical), e) atrial myxoma, f) other cardiac tumors, g) moderate or severe mitral stenosis, h) recent (< 4weeks) myocardial infarction, i) valvular vegetations, or j) infective endocarditis.
  • Any indication that requires treatment with an anticoagulant as per Investigator`s judgment.
  • History of atrial fibrillation (unless it was due to reversible causes such as hyperthyroidism or binge drinking, and has been permanently resolved).
  • Other specific stroke etiology (i.e. cerebral arteritis or arterial dissection, migraine with aura/vasospasm, drug abuse).
  • Renal impairment with estimated creatinine clearance (as calculated by Cockcroft-Gault equation) <30mL/min at screening, or where Investigator expects creatinine clearance is likely to drop below 30mL/min during the course of the study.

Further exclusion criteria apply.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02239120


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Locations
United States, Arizona
Bronislava Shafran, MD PC
Phoenix, Arizona, United States, 85006
United States, Arkansas
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205
United States, California
Westside Medical Associates of Los Angeles
Beverly Hills, California, United States, 90211
TriWest Research Associates, LLC
El Cajon, California, United States, 92020
University of California
Fresno, California, United States, 93721
Glendale Adventist Medical Center
Glendale, California, United States, 91206
Collaborative Neuroscience Network, LLC (CNS)
Long Beach, California, United States, 90806
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States, 90027
University of California
Los Angeles, California, United States, 90095
Huntington Hospital
Pasadena, California, United States, 91105
University of California
San Diego, California, United States, 92103
University of California
San Francisco, California, United States, 94143
Harmeet Sachdev, MD
San Jose, California, United States, 95124
United States, Colorado
University of Colorado Denver
Aurora, Colorado, United States, 80045
Colorado Neurological Institute
Englewood, Colorado, United States, 80113
University of Colorado Denver
Fort Collins, Colorado, United States, 80528
St. Mary's Hospital and Regional Medical Center
Grand Junction, Colorado, United States, 81501
United States, Connecticut
Hartford Hospital
Hartford, Connecticut, United States, 06102
United States, District of Columbia
George Washington University Medical Faculty Associates
Washington, District of Columbia, United States, 20037
United States, Florida
JEM Research Institute
Atlantis, Florida, United States, 33462
Boca Raton Regional Hospital
Boca Raton, Florida, United States, 33486
Tenet Florida Physician Services
Boynton Beach, Florida, United States, 33472
Nova Clinical Research, LLC
Bradenton, Florida, United States, 34209
Broward Health North
Deerfield Beach, Florida, United States, 33064
Center for Advanced Research Excellence
Hialeah, Florida, United States, 33016
Bruce W. Carter, Miami VA Healthcare System
Miami, Florida, United States, 33125
University of Miami
Miami, Florida, United States, 33136
Bay Neurological Institute
Panama City, Florida, United States, 32405
Carol L Pappas, MD PhD PA
Saint Petersburg, Florida, United States, 33713
University of South Florida
Tampa, Florida, United States, 33606
Vero Beach Neurology and Research Institute
Vero Beach, Florida, United States, 32960
Palm Beach Neuroscience Institute
West Palm Beach, Florida, United States, 33409
United States, Georgia
Augusta University
Augusta, Georgia, United States, 30912
WellStar Medical Group - Neurosurgery
Marietta, Georgia, United States, 30060
United States, Hawaii
The Queen's Medical Center
Honolulu, Hawaii, United States, 96813
United States, Idaho
Saint Alphonsus Medical Center-Neurology
Boise, Idaho, United States, 83704
United States, Illinois
Northwest Heart Clinical Research, LLC
Arlington Heights, Illinois, United States, 60005
Northwestern University
Chicago, Illinois, United States, 60611
Rush University Medical Center
Chicago, Illinois, United States, 60612
University of Chicago
Chicago, Illinois, United States, 60637
Medicoricium, LLC
Fairview Heights, Illinois, United States, 62208
OSF Saint Francis Medical Center
Peoria, Illinois, United States, 61637
Quincy Physicians and Surgeons Clinic, S.C.
Quincy, Illinois, United States, 62301
Southern Illinois University School of Medicine
Springfield, Illinois, United States, 62702
United States, Indiana
Community Clinical Research Center
Anderson, Indiana, United States, 46011
Parkview Regional Medical Center
Fort Wayne, Indiana, United States, 46845
United States, Iowa
Ruan Neurology Clinic and Research Center
Des Moines, Iowa, United States, 50314
United States, Kentucky
Associates in Neurology, PSC
Lexington, Kentucky, United States, 40513
University of Louisville
Louisville, Kentucky, United States, 40202
United States, Louisiana
Alexandria Cardiology Clinic
Alexandria, Louisiana, United States, 71301
Culicchia Neurological Clinic
Marrero, Louisiana, United States, 70072
Tulane University Hospital and Clinic
New Orleans, Louisiana, United States, 70112
Ochsner Medical Center
New Orleans, Louisiana, United States, 70121
United States, Maryland
Anne Arundel Medical Center
Annapolis, Maryland, United States, 21401
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
United States, Massachusetts
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Newton-Wellesley Hospital
Newton, Massachusetts, United States, 02462
United States, Michigan
Henry Ford Health System
Detroit, Michigan, United States, 48202
McLaren Flint
Flint, Michigan, United States, 48532
Mercy Health Saint Mary's
Grand Rapids, Michigan, United States, 49503
Spectrum Health Medical Center
Grand Rapids, Michigan, United States, 49503
Sparrow Clinical Research Institute
Lansing, Michigan, United States, 48912
St. Joseph Mercy Oakland
Pontiac, Michigan, United States, 48341
United States, Minnesota
The Duluth Clinic dba Essentia Health Duluth Clinic
Duluth, Minnesota, United States, 55805
Abbott Northwestern Hospital, Radiology Department
Minneapolis, Minnesota, United States, 55407
HealthPartners Neuroscience Center
Saint Paul, Minnesota, United States, 55130
United States, Mississippi
Jackson Heart Clinic, P.A.
Jackson, Mississippi, United States, 39216
United States, Missouri
Boone Hospital Center
Columbia, Missouri, United States, 65201
University of Missouri Health System
Columbia, Missouri, United States, 65201
SSM Health St. Clare Hospital
Fenton, Missouri, United States, 63026
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, United States, 64111
Saint Louis University
Saint Louis, Missouri, United States, 63104
Barnes Jewish Hospital Washington University
Saint Louis, Missouri, United States, 63110
St. Louis Heart and Vascular, P.C.
Saint Louis, Missouri, United States, 63136
Mercy Hospital Springfield
Springfield, Missouri, United States, 65804
United States, Nebraska
The Nebraska Medical Center
Omaha, Nebraska, United States, 68198
United States, Nevada
Renown Institute for Neurosciences
Reno, Nevada, United States, 89502
United States, New York
NYC Health + Hospitals/Coney Island
Brooklyn, New York, United States, 11235
New York Presbyterian Hudson Valley Hospital
Cortlandt Manor, New York, United States, 10567
NewYork-Presbyterian/Queens
Flushing, New York, United States, 11355
UHS Wilson Medical Center,Office of Clin Trials
Johnson City, New York, United States, 13790
North Shore University Hospital
Manhasset, New York, United States, 11030
Winthrop University Hospital
Mineola, New York, United States, 11501
Mount Sinai Beth Israel
New York, New York, United States, 10003
Rochester General Hospital
Rochester, New York, United States, 14621
United States, North Carolina
Novant Health Neurology Specialists
Charlotte, North Carolina, United States, 28207
Duke Clinic 1L
Durham, North Carolina, United States, 27710
Cone Health System
Greensboro, North Carolina, United States, 27401
Novant Health Neurology Hickory
Hickory, North Carolina, United States, 28602
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
United States, North Dakota
Altru Health System
Grand Forks, North Dakota, United States, 58201
United States, Ohio
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States, 43210
Holzer Clinic LLC
Gallipolis, Ohio, United States, 45631
Advanced Neurology Associates
Youngstown, Ohio, United States, 44504
United States, Oregon
Oregon Health and Sciences University
Portland, Oregon, United States, 97239
Veterans Affairs Portland Health Care System
Portland, Oregon, United States, 97239
Sacred Heart Medical Center at RiverBend
Springfield, Oregon, United States, 97477
United States, Pennsylvania
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
Temple University School of Medicine
Philadelphia, Pennsylvania, United States, 19140
Einstein Medical Center Philadelphia
Philadelphia, Pennsylvania, United States, 19141
Abington Neurological Associates
Willow Grove, Pennsylvania, United States, 19090
United States, Rhode Island
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
United States, South Carolina
Greenville Memorial Hospital
Greenville, South Carolina, United States, 29605
United States, Tennessee
University of Tennessee Medical Center
Knoxville, Tennessee, United States, 37920
Methodist University Hospital
Memphis, Tennessee, United States, 38105
Centennial Heart Cardiovascular Consultants, LLC
Nashville, Tennessee, United States, 37203
Saint Thomas Health
Nashville, Tennessee, United States, 37205
United States, Texas
Seton Medical Center Austin
Austin, Texas, United States, 78705
Texas Tech University Health Sciences Center of El Paso
El Paso, Texas, United States, 79905
Lyndon Baines Johnson Hospital
Houston, Texas, United States, 77026
Houston Methodist Hospital
Houston, Texas, United States, 77030
The University Of Texas at Houston
Houston, Texas, United States, 77030
Bhupesh Dihenia, M.D.,P.A.
Lubbock, Texas, United States, 79410
United States, Vermont
University of Vermont
Burlington, Vermont, United States, 05401
United States, Virginia
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Carilion Riverside
Roanoke, Virginia, United States, 24016
United States, Washington
Virginia Mason Medical Center
Seattle, Washington, United States, 98101
Swedish Neuroscience Institute
Seattle, Washington, United States, 98122
United States, West Virginia
Marshall University
Huntington, West Virginia, United States, 25701
United States, Wisconsin
Aurora BayCare Medical Center
Green Bay, Wisconsin, United States, 54311
University of Wisconsin
Madison, Wisconsin, United States, 53792
Argentina
STAT Research
Caba, Argentina, C1023AAB
Fundación Favaloro
Caba, Argentina, C1093AAS
Hospital Italiano de Buenos Aires
Caba, Argentina, C1199ABD
Instituto Médico DAMIC S.R.L.
Cordoba, Argentina, X5003DCE
Clinica Coronel Suarez SA
Coronel Suarez, Argentina, B7540DOL
Hospital Privado de Comunidad
Mar del Plata, Argentina, B7600CBM
Australia, New South Wales
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, 2050
St. Vincent's Hospital (SYD)
Darlinghurst, New South Wales, Australia, 2010
Kanwal Medical Complex
Kanwal, New South Wales, Australia, 2259
John Hunter Hospital
New Lambton, New South Wales, Australia, 2305
Royal North Shore Hospital
St Leonards, New South Wales, Australia, 2038
Australia, Queensland
Royal Brisbane & Women's Hospital
Herston, Queensland, Australia, 4029
Nambour General Hospital
Nambour, Queensland, Australia, 4560
Australia, South Australia
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Calvary North Adelaide Hospital
Adelaide, South Australia, Australia, 5001
Australia, Victoria
Box Hill Hospital
Box Hill, Victoria, Australia, 3128
Austin Health
Heidelberg, Victoria, Australia, 3084
Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Australia
Alfred Health
Victoria, Australia, 3004
Austria
LKH-Univ. Klinikum Graz
Graz, Austria, 8036
Medical University of Innsbruck
Innsbruck, Austria, 6020
Kepler Univ. Klinikum Linz
Linz, Austria, 4020
Kepler Univ. Klinikum Linz
Linz, Austria, 4021
KH d. Barmherzigen Brüder Linz, Neurologie
Linz, Austria, 4021
Universitätsklinikum Tulln, Abteilung für Neurologie
Tulln, Austria, 3430
Hosp.Hietzing with Neuro.Centr Rosenhuegel,II Neuro.dep,Wien
Vienna, Austria, 1130
Wilhelminenspital
Wien, Austria, 1160
Belgium
Aalst - HOSP Onze-Lieve-Vrouw
Aalst, Belgium, 9300
Arlon - HOSP Sud Luxembourg - Vivalia
Arlon, Belgium, 6700
AZ Sint-Jan Brugge
Brugge, Belgium, 3000
Brussels-UNIV Brugmann -Horta
Brussel, Belgium, 1020
Brussels - HOSP Europe (Ste-Elisabeth)
Brussel, Belgium, 1180
Brussels - UNIV St-Luc
Bruxelles, Belgium, 1200
UNIV UZ Gent
Gent, Belgium, 9000
Kortrijk - HOSP AZ Groeninge Kennedylaan
Kortrijk, Belgium, 8500
UZ Leuven
Leuven, Belgium, 3000
Liège - HOSP St-Joseph
Liège, Belgium, 4000
Roeselare - HOSP AZ Delta
Roeselare, Belgium, 8800
Rumst - HOSP AZ Heilige Familie
Rumst, Belgium, 2840
Sint-Truiden - HOSP St-Trudo (St-Jozef)
Sint-Truiden, Belgium, 3800
Wilrijk - HOSP GZA (St-Augustinus)
Wilrijk, Belgium, 2610
Yvoir - UNIV UCL de Mont-Godinne
Yvoir, Belgium, 5530
Brazil
Hospital Clinicas de Botucatu
Botucatu, Brazil, 18618-000
Instituto de Medicina Flumignano
Curitiba, Brazil, 80050-250
Clinica Neurologica e Neurocirurgica de Joinvile
Joinvile, Brazil, 89202-165
Hospital de Clínicas de Porto Alegre
Porto Alegre, Brazil, 90035-903
H.C.da Fac. de Medicina de Ribeirao Preto
Ribeirao Preto, Brazil, 14048-900
Hospital Quinta D¿Or
Rio de Janeiro, Brazil
Canada, Alberta
Foothills Medical Centre
Calgary, Alberta, Canada, T2N 2T9
University of Alberta Hospital (University of Alberta)
Edmonton, Alberta, Canada, T6G 2B7
Grey Nuns Hospital
Edmonton, Alberta, Canada, T6L 5X8
Canada, Manitoba
Prairie Mountain Health
Brandon, Manitoba, Canada, R7A 2B3
Canada, Migration Data
CSSS de Chicoutimi
Chicoutimi, Migration Data, Canada, G7H 5H6
Centre de Recherche-Hopital Charles-Lemoyne
Greenfield Park, Migration Data, Canada, J4V 2H1
Hopital Notre-Dame du CHUM
Montreal, Migration Data, Canada, H2L 4M1
CHU de Quebec-Hopital de l'Enfant-Jesus
Quebec, Migration Data, Canada, G1J 1Z4
Canada, New Brunswick
Saint John Regional Hospital
Saint John, New Brunswick, Canada, E2L 4L2
Canada, Newfoundland and Labrador
Eastern Health (MUN)
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Canada, Ontario
Victoria Hospital (LHSC)
London, Ontario, Canada, N6A 5A5
St. Michael's Hospital
Toronto, Ontario, Canada, M5C 1R6
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8
Canada, Quebec
Montreal General Hospital - McGill University Health Centre
Montreal, Quebec, Canada, H3G 1A4
CHUS Fleurimont
Sherbrooke, Quebec, Canada, J1H 5N4
St Jerome Medical Research Inc.
St-Jerome, Quebec, Canada, J7Z 5T3
Chile
Clínica Alemana de Santiago S.A.
Santiago, Chile, 7650568
Clínica Dávila
Santiago, Chile
Clinica Alemana de Temuco
Temuco, Chile
China
Beijing Tiantan Hospital affiliated to Cap Med University
Beijing, China, 100050
Peking University Third Hospital
Beijing, China, 100191
First Hospital of Jilin University
Changchun, China, 130021
Xiangya Hospital, Central South University
Changsha, China, 410008
First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China, 510000
First Affiliated Hospital of Guangzhou University of TCM
Guangzhou, China, 510000
The First Affiliated Hospital of Jinan University
Guangzhou, China, 510630
The Affiliated Hospital of Guizhou Medical University
Guiyang, China, 550000
2nd Affiliated Hosp Zhejiang University College of Medical
Hangzhou, China, 310009
Zhejiang Hospital
Hangzhou, China, 310013
Hangzhou Second People's Hospital
Hangzhou, China, 310015
Sir Run Run Shaw Hospital
Hangzhou, China, 310016
Jinlin Central Hospital
Jilin, China, 132602
The Second Affiliated Hospital to Nanchang University
Nanchang, China, 330006
Nanjing Drum Tower Hospital
Nanjing, China, 210008
Zhongda Hospital Southeast University
Nanjing, China, 210009
QingDao Municipal Hospital
Qingdao, China, 266071
The affiliated hospital of medicalcollege qingdao university
Qingdao, China, 266555
Shanghai Changzheng Hospital
Shanghai, China, 200003
Huashan Hospital, Fudan University
Shanghai, China, 200040
Tongji Hospital, Tongji University
Shanghai, China, 200065
Shanghai First People's Hospital
Shanghai, China, 200080
General Hospital of Shenyang Military Region
Shenyang, China, 110016
First Affiliated Hospital of Xiamen University
Xiamen, China, 361003
Affiliated Hospital, Xuzhou Medical college
Xuzhou, China, 221002
Colombia
Servicios Médicos Muñoz Solano
Bogotá, Colombia
Sociedad de Cirugia de Bogota Hospital de San José
Bogotá, Colombia
Fundación Valle del Lili
Cali, Colombia
Fundación Cardiovascular de Colombia
Floridablanca, Colombia
Croatia
General Hospital Varazdin
Varazdin, Croatia, 42000
Clin.Hosp.Centre Zagreb,Cerebrovascul.disease w/ intens.care
Zagreb, Croatia, 10 000
Clinical Hospital Centre Zagreb
Zagreb, Croatia, 10 000
Univ. Hosp. Sisters of Mercy, Neurology Clinic, Zagreb
Zagreb, Croatia, 100 00
Czechia
Cerebrovascular site, private prac., Brno
Brno, Czechia, 60200
Hospital Jihlava
Jihlava, Czechia, 58633
University Hospital Olomouc
Olomouc, Czechia, 77900
Cerebrovascular site, Ostrava
Ostrava, Czechia, 70300
Cerebrovascular site, Ostrava
Ostrava, Czechia, 70800
Hospital Homolka, Prague
Prague 5, Czechia, 15006
University Hospital Motol
Praha 5, Czechia, 150 06
Estonia
East Estonia Central Hospital, Neurology Dept, Ahtme
Ahtme, Estonia, 31025
West Tallinn Central Hospital, Neurology Dept.
Tallinn, Estonia, 10617
North Estonia Medical Centre Foundation, Tallin
Tallinn, Estonia, 13419
Tartu University Hospital
Tartu, Estonia, 51014
France
HOP Pays d'Aix
Aix en Provence, France, 13616
HOP de Bayonne
Bayonne Cedex, France, 64109
HOP J.Minjoz, Neuro, Besançon
Besançon cedex, France, 25030
HOP Pellegrin
Bordeaux cedex, France, 33076
HOP de la Cavale Blanche
Brest, France, 29609
HOP P. Wertheimer
Bron cedex, France, 69677
HOP Côte de Nacre
Caen, France, 14033
HOP Grenoble, Neuro, Grenoble
Grenoble, France, 38043
HOP Roger Salengro
Lille cedex, France, 59037
HOP CHR Metz-Thionville, Neuro
Metz cedex 03, France, 57085
HOP Saint-Anne
Paris cedex 14, France, 75674
HOP Paris Saint-Joseph
Paris, France, 75014
HOP Purpan
Toulouse, France, 31059
Germany
Klinikum Altenburger Land GmbH
Altenburg, Germany, 04600
Neurologische Klinik GmbH, Bad Neustadt
Bad Neustadt/Saale, Germany, 97616
Vivantes Netzwerk für Gesundheit GmbH
Berlin, Germany, 12351
Evangelisches Klinikum Bethel gGmbH
Bielefeld, Germany, 33611
Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil gGmbH
Bochum, Germany, 44789
St. Josef- und St. Elisabeth-Hospital gGmbH
Bochum, Germany, 44791
Gesundheit Nord gGmbH | Klinikverbund Bremen
Bremen, Germany, 28177
Klinikum Bremerhaven
Bremen, Germany, 28755
Krankenhäuser Buchholz und Winsen gGmbH
Buchholz, Germany, 21244
Allgemeines Krankenhaus, Celle
Celle, Germany, 29223
Klinikum Chemnitz gGmbH
Chemnitz, Germany, 09131
Klinikum Coburg gGmbH
Coburg, Germany, 96450
Klinikzentrum Mitte, Dortmund
Dortmund, Germany, 44137
Städtisches Klinikum Dresden
Dresden, Germany, 01067
Universitätsklinikum Carl Gustav Carus Dresden
Dresden, Germany, 01307
Universitätsklinikum Düsseldorf
Düsseldorf, Germany, 40225
Marien-Hospital, Düsseldorf
Düsseldorf, Germany, 40479
Universitätsklinikum Erlangen
Erlangen, Germany, 91054
Alfried Krupp Krankenhaus Essen
Essen, Germany, 45131
Universitätsklinikum Essen AöR
Essen, Germany, 45147
Universitätsklinikum Frankfurt
Frankfurt am Main, Germany, 60528
Klinikum Frankfurt Höchst GmbH
Frankfurt, Germany, 65929
Klinikum Friedrichshafen
Friedrichshafen, Germany, 88048
Klinikum Fulda gAG
Fulda, Germany, 36043
Evangelische Klinik Gelsenkirchen
Gelsenkirchen, Germany, 45879
SRH Wald-Klinikum Gera GmbH
Gera, Germany, 07548
Universitätsklinikum Gießen und Marburg GmbH
Gießen, Germany, 35385
Universitätsmedizin Greifswald
Greifswald, Germany, 17475
Bezirkskrankenhaus, Günzburg
Günzburg, Germany, 89312
Asklepios Klinik St. Georg
Hamburg, Germany, 20099
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Germany, 20246
Asklepios Klinik Harburg
Hamburg, Germany, 21075
Asklepios Klinik Wandsbek
Hamburg, Germany, 22043
Asklepios Klinik Barmbek
Hamburg, Germany, 22291
Asklepios Klinik Altona
Hamburg, Germany, 22763
Klinikum Hanau GmbH
Hanau, Germany, 63450
Medizinische Hochschule Hannover
Hannover, Germany, 30625
Universitätsklinikum Heidelberg
Heidelberg, Germany, 69120
SLK-Kliniken Heilbronn GmbH
Heilbronn, Germany, 74078
Klinikum Idar-Oberstein
Idar-Oberstein, Germany, 55743
Universitätsklinikum Jena
Jena, Germany, 07747
Universitätsklinikum Schleswig-Holstein, Campus Kiel
Kiel, Germany, 24105
Universitätsklinikum Köln (AöR)
Köln, Germany, 50937
Universitätsklinikum Leipzig
Leipzig, Germany, 04103
Klinikum der Stadt Ludwigshafen am Rhein gGmbH
Ludwigshafen, Germany, 67063
Universitätsklinikum Magdeburg AöR
Magdeburg, Germany, 39120
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, Germany, 55131
Universitätsklinikum Gießen und Marburg GmbH
Marburg, Germany, 35043
Elblandklinikum Meißen
Meißen, Germany, 01662
Johannes Wesling Klinikum
Minden, Germany, 32429
Kliniken Maria Hilf GmbH
Moenchengladbach, Germany, 41063
Ökumenisches Hainich Klinikum gGmbH
Mühlhausen, Germany, 99974
Klinikum der Universität München - Campus Großhadern
München, Germany, 81377
Klinikum rechts der Isar der Technischen Universität München
München, Germany, 81675
Universitätsklinikum Münster
Münster, Germany, 48129
Klinikum Nürnberg Süd
Nürnberg, Germany, 90471
Klinikum Offenbach GmbH
Offenbach, Germany, 63069
Klinikum Osnabrück GmbH
Osnabrück, Germany, 49076
Universitätsklinikum Regensburg
Regensburg, Germany, 93053
Nordwest-Krankenhaus Sanderbusch gGmbH
Sande, Germany, 26452
Kreisklinikum Siegen GmbH
Siegen, Germany, 57076
Bürgerhospital, Stuttgart
Stuttgart, Germany, 70174
Nervenklinik Teupitz, Teupitz
Teupitz, Germany, 15755
Krankenhaus der Barmherzigen Brüder Trier
Trier, Germany, 54292
Universitätsklinikum Tübingen
Tübingen, Germany, 72076
RKU - Universitäts- und Rehabilitationskliniken Ulm gGmbH
Ulm, Germany, 89081
Sophien- und Hufeland-Klinikum gGmbH
Weimar, Germany, 99425
Helios Kliniken Wiesbaden GmbH
Wiesbaden, Germany, 65199
Universitätsklinikum Würzburg
Würzburg, Germany, 97080
Greece
Univ.Hosp. of Alexandroupolis
Alexandroupolis, Greece, 68131
Gen.Hosp.of Ath.Evangelismos
Athens, Greece, 10676
Attikon University Hospital
Athens, Greece, 12462
Gen.Univ. Hosp. of Herakleion
Herakleion, Greece, 71306
Univ. Gen. Hosp. of Larissa
Larissa, Greece, 41110
Univ. Gen. Hosp. of Patras
Patras, Greece, 26504
Univ.Gen.Hosp. of Thessaloniki
Thessaloniki, Greece, 54636
Hong Kong
Prince of Wales Hospital
Hong Kong, Hong Kong, 0
Pamela Youde Nethersole Eastern Hospital
Hong Kong, Hong Kong
Queen Mary Hospital
Hong Kong, Hong Kong
Hungary
Semmelweis Univ, Neurology Clinic, Budapest
Budapest, Hungary, 1083
National Instit.of Neurosciences,Neurology Dept,Budapest
Budapest, Hungary, 1145
Univ. Debrecen Medical Health Science Center, Neurology Dept
Debrecen, Hungary, 4012
Pest Megyei Flor Ferenc Hospital
Kistarcsa, Hungary, 2143
CRU Hungary Ltd, Private Practice, Miskolc
Miskolc, Hungary, 3529
Univ. of Pecs Clinic for Neurology
Pecs, Hungary, 7623
India
St. Johns medical College and Hospital
Bangalore, India, 560034
Post Graduate Institute of Medical Education and Research
Chandigarh, India, 160012
Lalitha Super Specialities Hospital
Guntur, India, 522001
Nizam's Institute of Medical Sciences
Hyderabad, India, 500082
Shree Krishna Hospital and Research Centre
Karamsad, India, 388325
National Neurosciences Centre,Calcutta
Kolkata, India, 700094
Caritas Hospital
Kottayam, India, 686016
Mangala Hospital and Mangala Kidney Foundation
Mangalore, India, 575003
LTMMC & GH Medical College,
Mumbai, India, 400022
Magnum Heart Institute
Nashik, India, 422005
All India Institute of Medical Science
New Delhi, India, 110029
Sahyadri Speciality Hospital
Pune, India, 411004
Israel
Hillel Yaffe Medical Center, Hadera
Hadera, Israel, 38100
Wolfson Medical Center, Neurological department, Holon
Holon, Israel, 58100
Hadassah Medical Center, Ein-Karem
Jerusalem, Israel, 91120
The Chaim Sheba Medical Center Tel Hashomer
Tel Hashomer, Ramat Gan, Israel, 5265601
Sourasky Medical Center
Telaviv, Israel, 64239
Italy
Osp. SS Filippo Nicola
Avezzano, Italy, 67051
Policlinico S. Orsola Malpighi
Bologna, Italy, 40138
A.O. Spedali Civili di Brescia
Brescia, Italy, 25123
Azienda Ospedaliero Universitaria di Ferrara
Cona (FE), Italy, 44124
Policlinico San Martino
Genova, Italy, 16132
A.O.U.Policlinico G.Martino
Messina, Italy, 98125
Fondazione Centro San Raffaele del Monte Tabor
Milano, Italy, 20132
Istituto Auxologico Italiano
Milano, Italy, 20149
Nuovo Ospedale Civile S. Agostino-Estense
Modena, Italy, 41126
Azienda Ospedaliera Universitaria di Padova
Padova, Italy, 35128
Ospedale S.Maria della Misericordia, AO di Perugia
Perugia, Italy, 06156
Osp. Guglielmo da Saliceto AUSL di Piacenza
Piacenza, Italy, 29121
Ospedale Santa Corona Azienda Sanitaria Locale n.2 Savonese
Pietra Ligure, Italy, 17027
Università degli Studi Campus Bio-Medico
Roma, Italy, 00128
A.O. San Camillo Forlanini
Roma, Italy, 00152
Umberto I Pol. di Roma-Università di Roma La Sapienza
Roma, Italy, 00161
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
Roma, Italy, 00189
A.O.U. Senese Policlinico Santa Maria alle Scotte
Siena, Italy, 53100
Ospedale Molinette, AO Città della Salute e della
Torino, Italy, 10126
Ospedale Maria Vittoria
Torino, Italy, 10144
Ospedale S. Maria di Ca' Foncello Azienda ULSS9 TREVISO
Treviso, Italy, 31100
A. O. Ospedale Circolo Fond. Macchi
Varese, Italy, 21100
Ist. Ospitalieri "Borgo Trento"
Verona, Italy, 37126
Japan
Chubu Rosai Hospital
Aichi, Nagoya, Japan, 455-8530
National Hospital Organization Toyohashi Medical Center
Aichi, Toyohashi, Japan, 440-8510
Toyota Memorial Hospital
Aichi, Toyota, Japan, 471-8513
Reserch Institute for Brain and Blood Vessels Akita
Akita, Akita, Japan, 010-0874
Juntendo University Urayasu Hospital
Chiba, Urayasu, Japan, 279-0021
Go Neurosurgical Clinic
Fukuoka, Chikushi-gun, Japan, 811-1244
Fukuoka University Chikushi Hospital
Fukuoka, Chikushino, Japan, 818-8502
National Hospital Organization Kyushu Medical Center
Fukuoka, Fukuoka, Japan, 810-8563
Fukuoka Wajiro Hospital
Fukuoka, Fukuoka, Japan, 811-0213
Fukuoka University Hospital
Fukuoka, Fukuoka, Japan, 814-0180
Fukuoka Tokushukai Medical Center
Fukuoka, Kasuga, Japan, 816-0864
Steel Memorial Yawata Hospital
Fukuoka, Kitakyushu, Japan, 805-0050
Japan Community Health Care Organization Kyushu Hospital
Fukuoka, Kitakyushu, Japan, 806-8501
St. Mary's Hospital
Fukuoka, Kurume, Japan, 830-8543
Shin Koga Hospital
Fukuoka, Kurume, Japan, 830-8577
Fukuoka Shin Mizumaki Hospital
Fukuoka, Onga, Japan, 807-0051
Tagawa Hp., Fukuoka, NS
Fukuoka, Tagawa, Japan, 826-8585
Shin Yukuhashi Hospital
Fukuoka, Yukuhashi, Japan, 824-0026
Fujita General Hospital
Fukushima, Date-Gun, Japan, 969-1793
Shinseikai Masu Memorial Hospital
Fukushima, Nihonmatsu, Japan, 964-0867
Murakami Memorial Hospital Asahi University
Gifu, Gifu, Japan, 500-8523
Japanese Red Cross Takayama Hospital
Gifu, Takayama, Japan, 506-8550
Mihara Memorial Hospital
Gunma, Isesaki, Japan, 372-0006
Maebashi Red Cross Hospital
Gunma, Maebashi, Japan, 371-0014
Medical corporation Suiseikai Suiseikai Kajikawa Hospital
Hiroshima, Hiroshima, Japan, 730-0046
Araki Neurosurgical Hospital
Hiroshima, Hiroshima, Japan, 733-0821
Hiroshima Prefectural Hospital
Hiroshima, Hiroshima, Japan, 734-8530
Sapporo Shiroishi Memorial Hospital
Hokkaido, Sapporo, Japan, 003-0026
Nakamura Memorial Hospital
Hokkaido, Sapporo, Japan, 060-8570
Kobe City Medical Center General Hospital
Hyogo, Kobe, Japan, 650-0047
JA Toride Medical Center
Ibaraki, Toride, Japan, 302-0022
Tsukuba Medical Center Hospital
Ibaraki, Tsukuba, Japan, 305-8558
Iwate Medical University Hospital
Iwate, Morioka, Japan, 020-8505
Kagoshima City Hospital
Kagoshima, Kagoshima, Japan, 890-8760
National Hospital Organization Kagoshima Medical Center
Kagoshima, Kagoshima, Japan, 892-0853
Shonan Kamakura General Hospital
Kanagawa, Kamakura, Japan, 247-8533
Saiseikai Kumamoto Hospital
Kumamoto, Kumamoto, Japan, 861-4193
Japanese Red Cross Kumamoto Hospital
Kumamoto, Kumamoto, Japan, 861-8520
Kumamoto City Hospital
Kumamoto, Kumamoto, Japan, 862-8505
Uji-Tokushukai Medical Center
Kyoto, Uji, Japan, 611-0042
National Hospital Organization Sendai Medical Center
Miyagi, Sendai, Japan, 983-8520
South Miyagi Medical Center
Miyagi, Shibata-gun, Japan, 989-1253
Ina Central Hospital
Nagano, Ina, Japan, 396-8555
Nagano Municipal Hospital
Nagano, Naganoi, Japan, 381-8551
Nagasaki University Hospital
Nagasaki, Nagasaki, Japan, 852-8501
Nozaki Tokushukai Hospital
Osaka, Daito, Japan, 574-0074
Higashiosaka City Medical Center
Osaka, Higashiosaka, Japan, 578-8588
Wakakusa Daiichi Hospital
Osaka, Higashiosaka, Japan, 579-8056
Rinku General Medical Center
Osaka, Izumisano, Japan, 598-8577
Kishiwada Tokushukai Hospital
Osaka, Kishiwada, Japan, 596-0042
Yagi Neurosurgical Hospital
Osaka, Osaka, Japan, 537-0011
Tominaga Hospital
Osaka, Osaka, Japan, 556-0017
Osaka University Hospital
Osaka, Suita, Japan, 565-0871
Asakadai Central General Hospital
Saitama, Asaka, Japan, 315-8551
Saitama Medical University International Medical Center
Saitama, Hidaka, Japan, 350-1298
Sainokuni Higashiomiya Medical Center
Saitama, Saitama, Japan, 331-8577
Saitama Municipal Hospital
Saitama, Saitama, Japan, 336-8522
Nippon Medical School Hospital
Tokyo, Bunkyo-ku, Japan, 113-8603
Tokyo Metropolitan Geriatric Hospital
Tokyo, Itabashi-ku, Japan, 173-0015
Kyorin University Hospital
Tokyo, Mitaka, Japan, 181-8611
Tokyo Women's Medical University Hospital
Tokyo, Shinjuku-ku, Japan, 162-8666
Saiseikai Wakayama Hospital
Wakayama, Wakayama, Japan, 640-8158
Yamagata City Hospital SAISEIKAN
Yamagata, Yamagata, Japan, 990-8533
Korea, Republic of
Hallym University Sacred Heart Hospital
Anyang, Korea, Republic of, 431-070
Dong-A University Hospital
Busan, Korea, Republic of, 602-715
Kyungpook National Univ. Hosp
Daegu, Korea, Republic of, 700-721
Chungnam National University Hospital
Daejoen, Korea, Republic of, 301721
Inje University Ilsan Paik Hospital
Goyang, Korea, Republic of, 411-706
Chonnam National University Hospital
Gwangju, Korea, Republic of, 501-757
Chosun University Hospital
Gwangju, Korea, Republic of, 61453
Seoul National University Bundang Hospital
Seongnam, Korea, Republic of, 463-707
Severance Hospital, Yonsei University Health System
Seoul, Korea, Republic of, 120-752
Kangdong Sacred Heart Hospital
Seoul, Korea, Republic of, 134-701
Samsung Medical Center
Seoul, Korea, Republic of, 135-710
The Catholic University of Korea, Seoul St.Mary's Hospital
Seoul, Korea, Republic of, 137-701
Asan Medical Center
Seoul, Korea, Republic of, 138-736
Korea University Guro Hospital
Seoul, Korea, Republic of, 152-703
SMG-SNU Boramae Medical Center
Seoul, Korea, Republic of, 156-707
Chung-Ang University Hospital
Seoul, Korea, Republic of, 156-755
Ajou University Hospital
Suwon, Korea, Republic of, 443-380
Malaysia
Sarawak General Hospital
Kuching, Malaysia, 93586
Hospital Seberang Jaya
Pulau Pinang, Malaysia, 13700
Hospital Serdang
Selangor, Malaysia, 43300
Hospital Sultanah Nur Zahirah
Terengganu, Malaysia, 20400
Mexico
Hospital General de Culiacán &quot;Dr. Bernardo J. Gastellum&quot;
Culiacán, Mexico, 80230
CRI Centro Regiomontano de Investigación S.C.
Monterrey, Mexico, 64710
Hospital General &quot;Dr. Miguel Silva&quot;
Morelia, Mexico, 58000
Hospital Angeles del Pedregal
México, D.F., Mexico, 10700
Hospital Universitario Dr Jose Eleuterio Gonzalez
Nuevo Leon, Mexico, 64460
H. Central Dr Ignacio M. P.
San Luis Potosi, Mexico, 78250
New Zealand
Auckland City Hospital
Grafton / Auckland, New Zealand, 1010
North Shore Hospital, Takapuna
Takpuna Auckland, New Zealand, 0622
Wellington Hospital
Wellington, New Zealand, 6212
Peru
Hospital Nacional Carlos Alberto Seguín Escobedo
Arequipa, Peru
Instituto Nacional de Ciencias Neurológicas
Barrios Altos, Peru
Hospital Nacional Guillermo Almenara Irigoyen
La Victoria, Peru, Lima-13
Poland
PI HOUSE Sp. z o.o., Gdansk
Gdansk, Poland, 80546
Spec.Hosp.of Dr. Wladyslaw Bieganski in Grudziadz
Grudziadz, Poland, 86300
Univ.Clin.Centr Gibinski of Silesian Med,Neurol.dep,Katowice
Katowice, Poland, 40514
University Hospital in Krakow
Krakow, Poland, 31503
Center of Clinical Neurology, private prac, Krakow
Krakow, Poland, 31505
Clin.Research Center,Leszek Szczepanski,Private Prac.,Lublin
Lublin, Poland, 20022
Medicome Sp. z o.o.
Oswiecim, Poland, 32-600
Specialist Holy Spirit Hospital, Neurology Dept,Sandomierz
Sandomierz, Poland, 27600
Public Central Clinical Hosp,Neurology Clinic,Warsaw
Warsaw, Poland, 02097
Military Institute of Medicine Neurology Clinic, Warsaw
Warsaw, Poland, 04 141
Portugal
Hospital Garcia de Orta, EPE
Almada, Portugal, 2801-951
Hospital Fernando Fonseca, EPE
Amadora, Portugal, 2720-276
Hospital de Braga-Escala Braga
Braga, Portugal, 4710-243
CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
Coimbra, Portugal, 3004-561
CHLC, EPE - Hospital de São José
Lisboa, Portugal, 1150-199
CHLO, EPE - Hospital Egas Moniz
Lisboa, Portugal, 1349-019
CHLN, EPE - Hospital de Santa Maria
Lisboa, Portugal, 1649-035
Hospital Beatriz Ângelo
Loures, Portugal, 2674-514
ULSM, EPE - Hospital Pedro Hispano
Matosinhos, Portugal, 4454-509
H. Santo António - Centro Hospitalar do Porto
Porto, Portugal, 4099-001
Centro Hospitalar São João,EPE
Porto, Portugal, 4202-451
Centro Hospitalar de Entre o Douro e Vouga, E.P.E. - Hospital de São Sebastião
Santa Maria da Feira, Portugal, 4520-211
Russian Federation
Interreg. Clinical & Diagnostic Center, Neurol. Dept., Kazan
Kazan, Russian Federation, 420101
Reg.Clin.Hosp#1 na S.V.Ochapovskiy,Neurology#1 Dep,Krasnodar
Krasnodar, Russian Federation, 350086
City Clin.Emergency Hosp of Kursk, Neurology Department No.2
Kursk, Russian Federation, 305035
Clin.Hosp#2,na.Semashko,Russ.Railways,Restorative Med&Rehab.
Moscow, Russian Federation, 107150
CityClin.Hosp na I.V.Davydovsky of Dept of Healthcare Moscow
Moscow, Russian Federation, 109240
Research&Clini Cent Neuropsychiatry Dep. Healthcare,Moscow
Moscow, Russian Federation, 115419
City Clin.Hosp#1na N.I.Pirogov,Dept of Healthcare of Moscow
Moscow, Russian Federation, 117049
Ltd liabilityCom.CityNeurologic Cntr Sibneiromed,Novosibirsk
Novosibirsk, Russian Federation, 630091
Saratov State Med.Univ na V.I.Razumovsky,FacultyTherapy Clin
Saratov, Russian Federation, 410054
Reg.State Instit.of Healthc.Smolensk Reg.Clin.Hosp,Neurology
Smolensk, Russian Federation, 214018
Research Inst. of Emerg. Med., Vascul. Center,St. Petersburg
St. Petersburg, Russian Federation, 192242
Military Medical Academy n.a. S. M. Kirov, St. Petersburg
St. Petersburg, Russian Federation, 194044
Sverdlovsk Reg.Clin.Hosp.No.1
Yekaterinburg, Russian Federation, 620102
Serbia
Clinical Center of Serbia
Belgrade, Serbia, 11000
Special Hosp.for Cerebrovascul.Disease,'Sveti Sava,Belgrade
Belgrade, Serbia, 11000
Clinical Centre Nis
Nis, Serbia, 18000
Clinical Center of Vojvodina
Novi Sad, Serbia, 21000
Singapore
National University Hospital
Singapore, Singapore, 119074
Singapore General Hospital
Singapore, Singapore, 169037
National Neuroscience Institute
Singapore, Singapore, 308433
Slovakia
Faculty Hospital L. Pasteura, Kosice
Kosice, Slovakia, 40 66
Faculty Hospital Nitra
Nitra, Slovakia, 950 01
Slovenia
Instit.f.applicative Research in med.rehab.Dobrna
Dobrna, Slovenia, 3204
Cardial d.o.o., Specialist out-patient unit, Ljubljana
Ljubljana, Slovenia, 1000
Univ. Medical Center Maribor
Maribor, Slovenia, 2000
South Africa
Iatros International
Bloemfontein, South Africa, 9301
Dr C. Coetzee
Gateway, South Africa, 4321
Excellentis Clinical Trials
George, South Africa, 6529
University of Pretoria
Pretoria, South Africa, 0002
Vergelegen Medi-Clinic
Somerset West, South Africa, 7130
Dr. Moodley and Dr. Sarvan
Tongaat, South Africa, 4400
Spain
Hospital General Universitario de Albacete
Albacete, Spain, 02006
Hospital del Mar
Barcelona, Spain, 08003
Hospital Santa Creu i Sant Pau
Barcelona, Spain, 08025
Hospital Vall d'Hebron
Barcelona, Spain, 08035
Hospital Universitari de Girona Doctor Josep Trueta
Girona, Spain, 17007
Hospital Arnau de Vilanova
Lleida, Spain, 25198
Hospital La Princesa
Madrid, Spain, 28006
Hospital General Universitario Gregorio Marañón
Madrid, Spain, 28007
Hospital Ramón y Cajal
Madrid, Spain, 28034
Hospital Clínico San Carlos
Madrid, Spain, 28040
Hospital La Paz
Madrid, Spain, 28046
Hospital Son Espases
Palma de Mallorca, Spain, 07010
Complejo Hospitalario de Navarra
Pamplona, Spain, 31008
Hospital Universitario Donostia
San Sebastian, Spain, 20014
Hospital Clínico de Santiago
Santiago de Compostela, Spain, 15706
Hospital Virgen del Rocío
Sevilla, Spain, 41013
Hospital Universitari Joan XXIII
Tarragona, Spain, 43005
Hospital Mútua Terrassa
Tarrasa (Barcelona), Spain, 08221
Hospital Clínico de Valencia
Valencia, Spain, 46010
Hospital Clínico Universitario de Valladolid
Valladolid, Spain, 47005
Sweden
Sahlgrenska US, Göteborg
Göteborg, Sweden, 413 45
Sahlgrenska Universitetssjukhuset, Östra
Göteborg, Sweden, 416 85
Skaraborgs Sjukhus
Skövde, Sweden, 541 85
Karolinska Univ. sjukhuset
Stockholm, Sweden, 141 86
Karolinska Univ. sjukhuset
Stockholm, Sweden, 171 76
Danderyds Sjukhus
Stockholm, Sweden, 182 88
Switzerland
Canton Hospital Aarau, Neurology Dept., Stroke Center
Aarau, Switzerland, 5001
Universitätsspital Basel
Basel, Switzerland, 4031
Univ. Hospital Bern, Neurology Dept, Stroke Center
Bern, Switzerland, 3010
CHUV - Centre hospitalier universitaire vaudois
Lausanne, Switzerland, 1011
Regional Hospital Lugano,Neurocenter of Southern Switzerland
Lugano, Switzerland, 6903
Kantonsspital St.Gallen
St. Gallen, Switzerland, 9007
University Hosp. Zürich, Dept. of Neurology, Stroke Center
Zürich, Switzerland, 8901
Taiwan
Chang-Hua Christian Hospital
Changhua, Taiwan, 500
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung, Taiwan, 83301
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan, 8807
China Medical University Hospital
Taichung, Taiwan, 404
Taichung Veterans General Hospital
Taichung, Taiwan, 40750
Chi Mei Medical Center
Tainan,, Taiwan, 71004
NCKUH
Tainan, Taiwan, 704
National Taiwan University Hospital
Taipei, Taiwan, 100
Mackay Memorial Hospital
Taipei, Taiwan, 10449
Cheng Hsin General Hospital
Taipei, Taiwan, 112
Taipe Veterans General Hospital
Taipei, Taiwan, 112
Tri-Service General Hospital
Taipei, Taiwan, 11490
Chang Gung Memorial Hospital(TaoYuan)
Taoyuan, Taiwan, 330
Thailand
Chulalongkorn University
Bangkok, Thailand, 10330
Ramathibodi Hospital
Bangkok, Thailand, 10400
Siriraj Hospital
Bangkok, Thailand, 10700
Lampang Hospital
Lampang, Thailand, 52000
Turkey
Ankara Universitesi Tip Fakultesi
Ankara, Turkey, 06100
Hacettepe Universitesi Tip Fakultesi Noroloji A.B.D.
Ankara, Turkey, 06100
Gazi Universitesi Tip Fakultesi
Ankara, Turkey, 06500
Eskisehir Osmangazi Universitesi Tip Fakultesi
Eskisehir, Turkey, 26480
Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi
Istanbul, Turkey, 34093
Istanbul Universitesi Istanbul Tip Fakultesi Noroloji A.B.D.
Istanbul, Turkey, 34093
Istanbul Universitesi Cerrahpasa Tip Fakultesi
Istanbul, Turkey, 34098
Bakırkoy Dr. Sadi Konuk Egitim Ve Arastirma Hastanesi
Istanbul, Turkey, 34147
Bakirkoy Prof. Dr. Mazhar Osman Ruh Sagligi ve Sinir Hastaliklari
Istanbul, Turkey, 34147
Sisli Hamidiye Etfal Egitim ve Arastirma Hastanesi
Istanbul, Turkey, 34371
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi
Istanbul, Turkey, 34890
Dokuz Eylul Universitesi Tip Fakultesi Noroloji A.B.D.
Izmir, Turkey, 35340
Ondokuz Mayis Universitesi Tip Fakultesi
Samsun, Turkey, 55139
Namik Kemal Universitesi Tip Fakultesi
Tekirdag, Turkey, 59100
Ukraine
Bukovinian Med.Univ.Chernivtsi Reg.Psychiatric Hosp,Neurolog
Chernivtsi, Ukraine, 58018
City Clinical Hospital No. 7, Kharkov
Kharkiv, Ukraine, 76000
Instit.of Neurol,Psychiatry&amp;amp;Narcol,Vascul. Malformations Dep
Kharkiv, Ukraine, 76000
Instit.of Gerontology na D.F.Chebotarev,Brain Vascular Path.
Kyiv, Ukraine, 4114
Lviv Regional Clinical Hospital, Lviv
Lviv, Ukraine, 79010
Ternopil State Med.Univ.na Gorbachevskiy,Neurology Dept N3
Ternopil, Ukraine, 46027
Vinnitsia Reg.Psychoneurol.Hosp.na Yushchenko,Dept.N3,Neurol
Vinnitsia, Ukraine, 21005
Zhytomyr Reg.ClinHosp na Gerbachevskiy RegCouncil,Neurol.Dep
Zhytomyr, Ukraine, 10002
Sponsors and Collaborators
Boehringer Ingelheim
Investigators
Study Chair: Boehringer Ingelheim Boehringer Ingelheim

Responsible Party: Boehringer Ingelheim
ClinicalTrials.gov Identifier: NCT02239120     History of Changes
Other Study ID Numbers: 1160.189
2013-003444-24 ( EudraCT Number )
First Posted: September 12, 2014    Key Record Dates
Last Update Posted: September 3, 2018
Last Verified: August 2018

Additional relevant MeSH terms:
Stroke
Neoplasm Metastasis
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Neoplastic Processes
Neoplasms
Pathologic Processes
Dabigatran
Antithrombins
Serine Proteinase Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anticoagulants