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Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)

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ClinicalTrials.gov Identifier: NCT02196870
Recruitment Status : Completed
First Posted : July 22, 2014
Last Update Posted : June 24, 2015
Sponsor:
Information provided by (Responsible Party):
Jianfeng Xie, Southeast University, China

Study Description
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Brief Summary:
Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

Condition or disease
Airway Pressure Stress Index Transpulmonary Pressure Stress Index Acute Respiratory Failure Chest Wall Elastance

Detailed Description:

Mechanical ventilation(MV) is an important treatment for acute respiratory failure(ARF) patients, could improve hypoxemia, maintain lung volume and promote alveolar opening. However, because of barotrauma, volutrauma and biotrauma, MV could cause or aggravate acute lung injury not only in acute respiratory distress syndrome(ARDS) patients, but in patients with normal lung function1,2.

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

The present study is set out to examine the effects of high chest wall elastance on changes of lung mechanics and the correlation of airway pressure(Paw) stress index and transpulmonary pressure(PL) stress index.


Study Design
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Study Type : Observational [Patient Registry]
Actual Enrollment : 12 participants
Observational Model: Case Control
Time Perspective: Prospective
Target Follow-Up Duration: 3 Years
Official Title: Physiological Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure Patientstranspulmonary Pressure
Study Start Date : July 2014
Actual Primary Completion Date : June 2015
Actual Study Completion Date : June 2015

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Groups and Cohorts
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Outcome Measures
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :
  1. Changes of oxygenation and lung mechanics [ Time Frame: up to 24 months ]

Eligibility Criteria
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
acute respiratory failure patients
Criteria

Inclusion Criteria:

  • ARF
  • mechanical ventilation
  • cardiovascular stable

Exclusion Criteria:

  • age < 18y or > 85y
  • pregnancy
  • COPD or chronic pulmonary disease
Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02196870


Locations
China, Jiangsu
Zhongda Hospital
Nanjing, Jiangsu, China, 210009
Sponsors and Collaborators
Southeast University, China
Investigators
Principal Investigator: Jianfeng Xie, Dr. Zhongda hospital, Southeast University, Jiangsu, China
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Jianfeng Xie, Department of Critical Care Medicine, Zhong-Da Hospital, Southeast University, China
ClinicalTrials.gov Identifier: NCT02196870     History of Changes
Other Study ID Numbers: Chest wall Elastance in ARF
First Posted: July 22, 2014    Key Record Dates
Last Update Posted: June 24, 2015
Last Verified: June 2015

Keywords provided by Jianfeng Xie, Southeast University, China:
Airway pressure stress index
Transpulmonary pressure stress index
Acute Respiratory Failure
Chest wall elastance
Lung stress

Additional relevant MeSH terms:
Respiratory Insufficiency
Respiratory Distress Syndrome, Adult
Respiration Disorders
Respiratory Tract Diseases
Lung Diseases