Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)
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ClinicalTrials.gov Identifier: NCT02196870 |
Recruitment Status
:
Completed
First Posted
: July 22, 2014
Last Update Posted
: June 24, 2015
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Condition or disease |
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Airway Pressure Stress Index Transpulmonary Pressure Stress Index Acute Respiratory Failure Chest Wall Elastance |
Mechanical ventilation(MV) is an important treatment for acute respiratory failure(ARF) patients, could improve hypoxemia, maintain lung volume and promote alveolar opening. However, because of barotrauma, volutrauma and biotrauma, MV could cause or aggravate acute lung injury not only in acute respiratory distress syndrome(ARDS) patients, but in patients with normal lung function1,2.
Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.
The present study is set out to examine the effects of high chest wall elastance on changes of lung mechanics and the correlation of airway pressure(Paw) stress index and transpulmonary pressure(PL) stress index.
Study Type : | Observational [Patient Registry] |
Actual Enrollment : | 12 participants |
Observational Model: | Case Control |
Time Perspective: | Prospective |
Target Follow-Up Duration: | 3 Years |
Official Title: | Physiological Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure Patientstranspulmonary Pressure |
Study Start Date : | July 2014 |
Actual Primary Completion Date : | June 2015 |
Actual Study Completion Date : | June 2015 |

- Changes of oxygenation and lung mechanics [ Time Frame: up to 24 months ]

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Ages Eligible for Study: | 18 Years to 85 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- ARF
- mechanical ventilation
- cardiovascular stable
Exclusion Criteria:
- age < 18y or > 85y
- pregnancy
- COPD or chronic pulmonary disease

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02196870
China, Jiangsu | |
Zhongda Hospital | |
Nanjing, Jiangsu, China, 210009 |
Principal Investigator: | Jianfeng Xie, Dr. | Zhongda hospital, Southeast University, Jiangsu, China |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Jianfeng Xie, Department of Critical Care Medicine, Zhong-Da Hospital, Southeast University, China |
ClinicalTrials.gov Identifier: | NCT02196870 History of Changes |
Other Study ID Numbers: |
Chest wall Elastance in ARF |
First Posted: | July 22, 2014 Key Record Dates |
Last Update Posted: | June 24, 2015 |
Last Verified: | June 2015 |
Keywords provided by Jianfeng Xie, Southeast University, China:
Airway pressure stress index Transpulmonary pressure stress index Acute Respiratory Failure Chest wall elastance Lung stress |
Additional relevant MeSH terms:
Respiratory Insufficiency Respiratory Distress Syndrome, Adult Respiration Disorders Respiratory Tract Diseases Lung Diseases |