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Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT02196870
First Posted: July 22, 2014
Last Update Posted: June 24, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Jianfeng Xie, Southeast University, China
  Purpose
Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

Condition
Airway Pressure Stress Index Transpulmonary Pressure Stress Index Acute Respiratory Failure Chest Wall Elastance

Study Type: Observational [Patient Registry]
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Target Follow-Up Duration: 3 Years
Official Title: Physiological Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure Patientstranspulmonary Pressure

Resource links provided by NLM:


Further study details as provided by Jianfeng Xie, Southeast University, China:

Primary Outcome Measures:
  • Changes of oxygenation and lung mechanics [ Time Frame: up to 24 months ]

Enrollment: 12
Study Start Date: July 2014
Study Completion Date: June 2015
Primary Completion Date: June 2015 (Final data collection date for primary outcome measure)
Detailed Description:

Mechanical ventilation(MV) is an important treatment for acute respiratory failure(ARF) patients, could improve hypoxemia, maintain lung volume and promote alveolar opening. However, because of barotrauma, volutrauma and biotrauma, MV could cause or aggravate acute lung injury not only in acute respiratory distress syndrome(ARDS) patients, but in patients with normal lung function1,2.

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

The present study is set out to examine the effects of high chest wall elastance on changes of lung mechanics and the correlation of airway pressure(Paw) stress index and transpulmonary pressure(PL) stress index.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
acute respiratory failure patients
Criteria

Inclusion Criteria:

  • ARF
  • mechanical ventilation
  • cardiovascular stable

Exclusion Criteria:

  • age < 18y or > 85y
  • pregnancy
  • COPD or chronic pulmonary disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02196870


Locations
China, Jiangsu
Zhongda Hospital
Nanjing, Jiangsu, China, 210009
Sponsors and Collaborators
Southeast University, China
Investigators
Principal Investigator: Jianfeng Xie, Dr. Zhongda hospital, Southeast University, Jiangsu, China
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Jianfeng Xie, Department of Critical Care Medicine, Zhong-Da Hospital, Southeast University, China
ClinicalTrials.gov Identifier: NCT02196870     History of Changes
Other Study ID Numbers: Chest wall Elastance in ARF
First Submitted: July 12, 2014
First Posted: July 22, 2014
Last Update Posted: June 24, 2015
Last Verified: June 2015

Keywords provided by Jianfeng Xie, Southeast University, China:
Airway pressure stress index
Transpulmonary pressure stress index
Acute Respiratory Failure
Chest wall elastance
Lung stress

Additional relevant MeSH terms:
Respiratory Insufficiency
Respiratory Distress Syndrome, Adult
Respiration Disorders
Respiratory Tract Diseases
Lung Diseases