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Trial record 1 of 1 for:    NCT02115282
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Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or Metastatic

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02115282
Recruitment Status : Active, not recruiting
First Posted : April 16, 2014
Last Update Posted : November 8, 2019
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)

Brief Summary:
This randomized phase III trial studies exemestane and entinostat to see how well they work compared to exemestane alone in treating patients with hormone receptor-positive breast cancer that has spread to nearby tissue or lymph nodes (locally advanced) or another place in the body (metastatic). Estrogen can cause the growth of breast cancer cells. Endocrine therapy using exemestane may fight breast cancer by lowering the amount of estrogen the body makes. Entinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether exemestane is more effective with or without entinostat in treating breast cancer.

Condition or disease Intervention/treatment Phase
Breast Adenocarcinoma HER2/Neu Negative Locally Advanced Breast Carcinoma Metastatic Breast Carcinoma Recurrent Breast Carcinoma Stage III Breast Cancer AJCC v7 Stage IIIA Breast Cancer AJCC v7 Stage IIIB Breast Cancer AJCC v7 Stage IIIC Breast Cancer AJCC v7 Stage IV Breast Cancer AJCC v6 and v7 Drug: Entinostat Drug: Exemestane Drug: Goserelin Drug: Goserelin Acetate Other: Placebo Other: Quality-of-Life Assessment Phase 3

  Show Detailed Description

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 600 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: A Randomized Phase III Trial of Endocrine Therapy Plus Entinostat/Placebo in Patients With Hormone Receptor-Positive Advanced Breast Cancer
Actual Study Start Date : March 29, 2014
Estimated Primary Completion Date : January 14, 2021

Resource links provided by the National Library of Medicine

Drug Information available for: Exemestane

Arm Intervention/treatment
Experimental: Arm A (exemestane, entinostat)

Patients receive exemestane PO QD on days 1-28 and entinostat PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Pre/perimenopausal female patients and all male patients also receive goserelin acetate SC on day 1.

Drug: Entinostat
Given PO
Other Names:
  • HDAC inhibitor SNDX-275
  • MS 27-275
  • MS-275
  • SNDX-275

Drug: Exemestane
Given PO
Other Names:
  • Aromasin
  • FCE-24304

Drug: Goserelin
Given PO
Other Name: ICI-118630

Drug: Goserelin Acetate
Given SC
Other Names:
  • ZDX
  • Zoladex

Other: Quality-of-Life Assessment
Ancillary studies
Other Name: Quality of Life Assessment

Placebo Comparator: Arm B (exemestane, placebo)

Patients receive exemestane as in Arm A and placebo PO on days 1, 8, 15, and 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Pre/perimenopausal female patients and all male patients also receive goserelin acetate SC on day 1.

Drug: Exemestane
Given PO
Other Names:
  • Aromasin
  • FCE-24304

Drug: Goserelin
Given PO
Other Name: ICI-118630

Drug: Goserelin Acetate
Given SC
Other Names:
  • ZDX
  • Zoladex

Other: Placebo
Given PO
Other Names:
  • placebo therapy
  • PLCB
  • sham therapy

Other: Quality-of-Life Assessment
Ancillary studies
Other Name: Quality of Life Assessment




Primary Outcome Measures :
  1. Progression-free survival (PFS) [ Time Frame: Time from randomization to the earliest of documented disease progression, new primary breast cancer, or death without progression, assessed up to 10 years ]
    PFS will be defined by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 (v1.1). The distribution of PFS will be estimated using the Kaplan- Meier method, with 95% confidence intervals calculated using Greenwood's formula. In the primary analysis of PFS, differences in treatment effect will be tested using stratified log rank tests, stratifying on the randomization stratification factors. Stratified univariate and multivariable Cox proportional-hazard models will be built to estimate the hazard ratios (HRs) for treatment effect for PFS as a supportive analysis. In all analyses, P-values will be two-sided.

  2. Overall survival (OS) [ Time Frame: Time from randomization to death from any cause, assessed up to 70 months ]
    The distribution of OS will be estimated using the Kaplan- Meier method, with 95% confidence intervals calculated using Greenwood's formula. In the primary analyses of OS, differences in treatment effect will be tested using stratified log rank tests, stratifying on the randomization stratification factors. Stratified univariate and multivariable Cox proportional-hazard models will be built to estimate the HRs for treatment effect for OS as a supportive analysis. In all analyses, P-values will be two-sided.


Secondary Outcome Measures :
  1. Objective response [ Time Frame: Up to 10 years ]
    Objective response will be defined as the proportion of patients with complete response (CR) or partial response (PR) among all patients assessed per RESIST v1.1. Objective response in the two arms will be evaluated by comparing objective response rate (ORR, PR+CR) using a Fisher's exact test on the intention-to-treat patients with one-sided type I error of 2.5%. ORR will be summarized along with the exact binomial 95% confidence interval. In all analyses, P-values will be two-sided.

  2. Incidence of toxicity [ Time Frame: Up to 10 years ]
    Toxicity will be graded according to National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 (version 5.0 beginning April 1, 2018). All treatment-emergent and baseline adverse events and hematological/biochemical toxicities based on laboratory measurements, as well as drug related adverse events (AEs), will be summarized by treatment group and worst grade. The incidence of deaths and treatment-emergent serious AEs (defined as number of patients experiencing the AE divided by all treated patients) will be summarized and compared between treatment arms using Fisher's exact test. Also, the incidence of adverse events leading to discontinuation of investigational product and/or withdrawal from the study will be summarized and listed.

  3. Time to treatment deterioration (TTD) [ Time Frame: Time from randomization to disease progression or death or worsening of symptoms, whichever occurs first, assessed up to 10 years ]
    Will be assessed per RECIST v1.1. The distribution of TTD will be estimated using Kaplan-Meier method, and TTD comparisons between treatment arms will be tested primarily using log-rank test. Cox proportional-hazards models will be conducted to estimate the HR for treatment effect for TTD as a supportive analysis.


Other Outcome Measures:
  1. Percent change in protein lysine acetylation [ Time Frame: Baseline to up to 70 months ]
    The distribution of the percentage change in protein lysine acetylation will be plotted for the two treatment groups and difference will be compared using the Wilcoxon ranks sum test. Tumor response rate will be compared between the patients with percentage change in acetylation being above or below median using Fisher's exact tests in each treatment arm. In all analyses, P-values will be two-sided and a level of 5% will be considered statistically significant.

  2. Overall health-related quality of life (HRQL) score [ Time Frame: Up to 10 years ]
    HRQL will be measured by the Trial Outcome Index. Mixed effect models will be constructed to estimate the time profile of HRQL in the two treatment arms and to evaluate treatment-by-time interactions. Time will be included as a continuous variable if there is a linear trend in HRQL over time or a set of dummy variables if non-linear trend exits for HRQL. PROs will be correlated with PFS (prognostic value of PROs) in the study patients. Kaplan-Meier method, log rank test and Cox models will be used to compare PFS between patients with good quality of life (QOL) and those with poor QOL in the overall patient population.

  3. Adherence to study [ Time Frame: Up to 10 years ]
    The distribution of the adherence score for each agent will be displayed via box-and-whisker plot. The proportion of high, medium and low adherence to each agent will be calculated along with the binomial exact 95% confidence interval. The proportion of high adherence to entinostat and placebo will be compared between arms A and B using Fisher exact test. The proportion of adherence to exemestane will be compared between treatment arms using Fisher exact test as well.



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Estrogen receptor (ER) and/or progesterone receptor (PR) positive histologically confirmed adenocarcinoma of the breast with staining of >= 1% cells will be considered positive; receptor status may be based on any time during treatment prior to study randomization, and from any site (i.e. primary, recurrent, or metastatic)
  • Patients whose tumors have HER2 immunohistochemistry (IHC) 3+, in situ hybridization (ISH) >= 2.0, or average HER2 copy number >= 6.0 signals per cell are not eligible; receptor status may be based on any time during treatment prior to study randomization, and from any site (i.e. primary, recurrent, or metastatic)
  • Patients must have measurable or non-measurable stage III/locally advanced or metastatic carcinoma of the breast where local therapy with curative intent is not possible; lesions must be evaluated =< 4 weeks prior to study randomization; diagnostic-quality computed tomography (CT) scans with both oral and intravenous (IV) contrast are the expected radiologic method, unless an alternative is approved

    • NOTE: Where baseline imaging has already been performed =< 6 weeks prior to study randomization, repeat imaging may not be required
    • NOTE: As of October 16, 2016, accrual of new patients having non-measurable disease has stopped; the planned accrual for this target population has been reached
  • Pre/peri- and postmenopausal women and all men are eligible for this trial; postmenopausal is defined as:

    • Age >= 55 years and one year or more of amenorrhea
    • Age < 55 years and one year or more of amenorrhea, with estradiol < 20 pg/ml
    • Age < 55 with prior hysterectomy but intact ovaries, with estradiol < 20 pg/ml
    • Prior bilateral oophorectomy

      • NOTE: Women who do not fit the criteria for being postmenopausal as above are deemed pre-or peri-menopausal; pre/perimenopausal women and all men can enroll provided they agree to receive concomitant luteinizing hormone-releasing hormone (LHRH) agonist; pre/perimenopausal women must have commenced treatment with LHRH agonist at least 4 weeks prior to randomization; if patients have received alternative LHRH agonist prior to study entry, they must switch to goserelin for the duration of the trial
  • Sexually active males and pre/perimenopausal women must agree to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for 3 months after discontinuation of therapy
  • Women must not be pregnant or breast-feeding; all females of childbearing potential must have a blood test or urine study =< 2 weeks prior to randomization

    • A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • Patients must not have known central nervous system metastasis or a history of central nervous system (CNS) metastases; patients with leptomeningeal disease are not eligible
  • Patients must be disease-free of prior invasive malignancies for > 5 years with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix

    • NOTE: If there is a history of prior malignancy, patients must not be receiving other specific treatment for that cancer
  • Patients must meet at least one of the following criteria:

    • Disease progression any time after non-steroidal AI use in the advanced disease setting
    • Relapse while on or within =< 12 months of end of adjuvant non-steroidal AI therapy with or without prior endocrine therapy for advanced disease
    • NOTE: In either setting, treatment with any prior endocrine therapy must be completed >= 2 weeks prior to cycle 1 day 1 (C1D1) of study treatment with the exception of exemestane which is permitted in the advanced disease setting within =< 4 weeks immediately prior to C1D1; prior adjuvant exemestane is allowed if the disease free interval is > 12 months from the discontinuation of exemestane; prior faslodex, everolimus, palbociclib or other cyclin-dependent kinase (CDK) inhibitor (e.g. ribociclib, abemaciclib) use are allowed and must have been completed >= 2 weeks prior to C1D1; failure to adhere to this washout guideline will result in a protocol violation
  • Patients may have received only one prior chemotherapy regimen for metastatic disease provided treatment was completed >= 3 weeks prior to randomization
  • Patients may be treated with bone modifying agents such as bisphosphonates or RANK-ligand agents (e.g. denosumab) per American Society of Clinical Oncology (ASCO) guidelines; whenever possible, patients requiring bone modifying agents should start treatment >= 7 days prior to study therapy and should continue the same agent throughout study unless clinically compelled to change
  • Prior radiotherapy must in general have been completed >= 2 weeks prior to randomization and patients must have recovered from the toxicity of the radiation

    • NOTE: Patients may receive concurrent radiation therapy to painful sites of bony disease or areas of impending fracture as long as sites of measurable or non-measurable disease outside the radiation therapy port are available to follow
  • Patients must NOT receive concurrent anti-cancer therapy or investigational agent unless specified in protocol
  • Patients must NOT be receiving valproic acid, an histone deacetylase (HDAC) inhibitor, and may not have previously received any HDAC inhibitor prior to enrollment (e.g. valproic acid, entinostat, vorinostat) unless discussed with the study chair; patients must not have received prior HDAC therapy for the treatment of their malignancy
  • Patients must have no known allergies to exemestane, entinostat, or medications that have a benzamide structure (e.g., tiapride, remoxipride, clebropride)
  • Patients must NOT suffer from medical or psychiatric conditions that would interfere with protocol compliance, the ability to provide informed consent, or assessment of response or anticipated toxicities; this includes uncontrolled intercurrent illness including, but not limited to ongoing or active infection
  • Patients must have recovered from all clinically relevant adverse events to grade 1 or baseline due to previous agents administered (except alopecia)
  • Patients must have adequate hematologic, liver and renal function =< 28 days prior to randomization

    • NOTE: It is preferred that laboratory values for eligibility be assessed after the last dose of prior treatment, especially in cases where most-recent treatment prior to study entry is chemotherapy
  • Hemoglobin (HgB) >= 9.0 g/dL (=< 28 days prior to randomization)
  • Platelet count >= 100,000/mcL (=< 28 days prior to randomization)
  • Absolute neutrophil count >= 1,500/mcL (=< 28 days prior to randomization)
  • Creatinine =< 2.0 mg/dL (=< 28 days prior to randomization)
  • Total bilirubin < 1.5 x institutional upper limit of normal (=< 3 mg/dL in case of Gilbert's syndrome) (=< 28 days prior to randomization)
  • Transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) =< 2.5 x institutional upper limit normal (=< 28 days prior to randomization)
  • Known human immunodeficiency virus (HIV)-positive patients should have a cluster of differentiation (CD)4 count > 250/mm^3
  • Patients must have Eastern Cooperative Oncology Group (ECOG) performance status 0-1
  • Patients must have a life expectancy >= 12 weeks
  • Patients must be able to swallow tablets

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02115282


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Locations
Layout table for location information
United States, Alabama
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States, 35233
United States, Arkansas
Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States, 72401
United States, California
Mercy San Juan Medical Center
Carmichael, California, United States, 95608
Enloe Medical Center
Chico, California, United States, 95926
Adventist Health Cancer Care Center Chico
Chico, California, United States, 95973
Community Cancer Institute
Clovis, California, United States, 93611
University Oncology Associates
Clovis, California, United States, 93611
Eisenhower Medical Center
Rancho Mirage, California, United States, 92270
Mercy Cancer Center - Sacramento
Sacramento, California, United States, 95816
Saint Helena Hospital
Saint Helena, California, United States, 94574
Presbyterian Intercommunity Hospital
Whittier, California, United States, 90602
Woodland Memorial Hospital
Woodland, California, United States, 95695
United States, Colorado
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado, United States, 80012
The Medical Center of Aurora
Aurora, Colorado, United States, 80012
Boulder Community Hospital
Boulder, Colorado, United States, 80301
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, United States, 80304
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, United States, 80907
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, United States, 80907
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, United States, 80909
Porter Adventist Hospital
Denver, Colorado, United States, 80210
Colorado Blood Cancer Institute
Denver, Colorado, United States, 80218
Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado, United States, 80218
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado, United States, 80218
SCL Health Saint Joseph Hospital
Denver, Colorado, United States, 80218
Rocky Mountain Cancer Centers-Rose
Denver, Colorado, United States, 80220
Rose Medical Center
Denver, Colorado, United States, 80220
Mercy Medical Center
Durango, Colorado, United States, 81301
Southwest Oncology PC
Durango, Colorado, United States, 81301
Mountain Blue Cancer Care Center - Swedish
Englewood, Colorado, United States, 80113
Swedish Medical Center
Englewood, Colorado, United States, 80113
Mountain Blue Cancer Care Center
Golden, Colorado, United States, 80401
North Colorado Medical Center
Greeley, Colorado, United States, 80631
Rocky Mountain Cancer Centers-Greenwood Village
Greenwood Village, Colorado, United States, 80111
Rocky Mountain Cancer Centers-Lakewood
Lakewood, Colorado, United States, 80228
Saint Anthony Hospital
Lakewood, Colorado, United States, 80228
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado, United States, 80120
Littleton Adventist Hospital
Littleton, Colorado, United States, 80122
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado, United States, 80124
Sky Ridge Medical Center
Lone Tree, Colorado, United States, 80124
Longmont United Hospital
Longmont, Colorado, United States, 80501
Rocky Mountain Cancer Centers-Longmont
Longmont, Colorado, United States, 80501
McKee Medical Center
Loveland, Colorado, United States, 80539
Parker Adventist Hospital
Parker, Colorado, United States, 80138
Rocky Mountain Cancer Centers-Parker
Parker, Colorado, United States, 80138
Saint Mary Corwin Medical Center
Pueblo, Colorado, United States, 81004
Rocky Mountain Cancer Centers - Pueblo
Pueblo, Colorado, United States, 81008
Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado, United States, 80260
SCL Health Lutheran Medical Center
Wheat Ridge, Colorado, United States, 80033
United States, Connecticut
Yale-New Haven Shoreline Medical Center
Guilford, Connecticut, United States, 06437
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, United States, 06105
Manchester Memorial Hospital
Manchester, Connecticut, United States, 06040
Middlesex Hospital
Middletown, Connecticut, United States, 06457
The Hospital of Central Connecticut
New Britain, Connecticut, United States, 06050
Yale University
New Haven, Connecticut, United States, 06520
Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut, United States, 06477
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut, United States, 06790
Lawrence and Memorial Cancer Center
Waterford, Connecticut, United States, 06385
United States, Delaware
Bayhealth Hospital Kent Campus
Dover, Delaware, United States, 19901
Beebe Medical Center
Lewes, Delaware, United States, 19958
Helen F Graham Cancer Center
Newark, Delaware, United States, 19713
Medical Oncology Hematology Consultants PA
Newark, Delaware, United States, 19713
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States, 19718
Beebe Health Campus
Rehoboth Beach, Delaware, United States, 19971
Nanticoke Memorial Hospital
Seaford, Delaware, United States, 19973
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, United States, 19801
United States, District of Columbia
MedStar Georgetown University Hospital
Washington, District of Columbia, United States, 20007
MedStar Washington Hospital Center
Washington, District of Columbia, United States, 20010
Sibley Memorial Hospital
Washington, District of Columbia, United States, 20016
United States, Florida
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States, 33442
University of Florida Health Science Center - Gainesville
Gainesville, Florida, United States, 32610
Baptist MD Anderson Cancer Center
Jacksonville, Florida, United States, 32207
Lakeland Regional Health Hollis Cancer Center
Lakeland, Florida, United States, 33805
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States, 33136
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, United States, 33176
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States, 33324
Cleveland Clinic-Weston
Weston, Florida, United States, 33331
United States, Georgia
Grady Health System
Atlanta, Georgia, United States, 30303
Emory University Hospital Midtown
Atlanta, Georgia, United States, 30308
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Emory Saint Joseph's Hospital
Atlanta, Georgia, United States, 30342
John B Amos Cancer Center
Columbus, Georgia, United States, 31904
Medical Center of Central Georgia
Macon, Georgia, United States, 31201
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, United States, 31405
United States, Hawaii
Hawaii Oncology Inc-Pali Momi
'Aiea, Hawaii, United States, 96701
Pali Momi Medical Center
'Aiea, Hawaii, United States, 96701
Hawaii Cancer Care Inc-POB II
Honolulu, Hawaii, United States, 96813
Hawaii Oncology Inc-POB I
Honolulu, Hawaii, United States, 96813
Queen's Medical Center
Honolulu, Hawaii, United States, 96813
Straub Clinic and Hospital
Honolulu, Hawaii, United States, 96813
University of Hawaii Cancer Center
Honolulu, Hawaii, United States, 96813
Hawaii Cancer Care Inc-Liliha
Honolulu, Hawaii, United States, 96817
Hawaii Oncology Inc-Kuakini
Honolulu, Hawaii, United States, 96817
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, United States, 83706
Saint Luke's Mountain States Tumor Institute
Boise, Idaho, United States, 83712
Kootenai Medical Center
Coeur d'Alene, Idaho, United States, 83814
Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland, Idaho, United States, 83619
Kootenai Cancer Center
Post Falls, Idaho, United States, 83854
Kootenai Cancer Clinic
Sandpoint, Idaho, United States, 83864
Saint Luke's Mountain States Tumor Institute-Twin Falls
Twin Falls, Idaho, United States, 83301
United States, Illinois
Rush - Copley Medical Center
Aurora, Illinois, United States, 60504
Saint Joseph Medical Center
Bloomington, Illinois, United States, 61701
Illinois CancerCare-Bloomington
Bloomington, Illinois, United States, 61704
Illinois CancerCare-Canton
Canton, Illinois, United States, 61520
Memorial Hospital of Carbondale
Carbondale, Illinois, United States, 62902
Illinois CancerCare-Carthage
Carthage, Illinois, United States, 62321
Centralia Oncology Clinic
Centralia, Illinois, United States, 62801
Northwestern University
Chicago, Illinois, United States, 60611
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States, 60612
Swedish Covenant Hospital
Chicago, Illinois, United States, 60625
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States, 60637
Weiss Memorial Hospital
Chicago, Illinois, United States, 60640
Presence Saint Joseph Hospital-Chicago
Chicago, Illinois, United States, 60657
Carle on Vermilion
Danville, Illinois, United States, 61832
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States, 62526
Decatur Memorial Hospital
Decatur, Illinois, United States, 62526
Carle Physician Group-Effingham
Effingham, Illinois, United States, 62401
Crossroads Cancer Center
Effingham, Illinois, United States, 62401
AMITA Health Alexian Brothers Medical Center
Elk Grove Village, Illinois, United States, 60007
Elmhurst Memorial Hospital
Elmhurst, Illinois, United States, 60126
Illinois CancerCare-Eureka
Eureka, Illinois, United States, 61530
Saint Francis Hospital
Evanston, Illinois, United States, 60202
Freeport Memorial Hospital/Leonard C Ferguson Cancer Center
Freeport, Illinois, United States, 61032
Illinois CancerCare-Galesburg
Galesburg, Illinois, United States, 61401
Western Illinois Cancer Treatment Center
Galesburg, Illinois, United States, 61401
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States, 60134
Ingalls Memorial Hospital
Harvey, Illinois, United States, 60426
Joliet Oncology-Hematology Associates Limited
Joliet, Illinois, United States, 60435
Presence Saint Mary's Hospital
Kankakee, Illinois, United States, 60901
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, United States, 61443
Illinois CancerCare-Macomb
Macomb, Illinois, United States, 61455
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, United States, 61938
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Good Samaritan Regional Health Center
Mount Vernon, Illinois, United States, 62864
Edward Hospital/Cancer Center
Naperville, Illinois, United States, 60540
Community Cancer Center Foundation
Normal, Illinois, United States, 61761
Advocate Christ Medical Center
Oak Lawn, Illinois, United States, 60453-2699
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, United States, 61350
Radiation Oncology of Northern Illinois
Ottawa, Illinois, United States, 61350
Illinois CancerCare-Pekin
Pekin, Illinois, United States, 61554
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin, Illinois, United States, 61554
Illinois CancerCare-Peoria
Peoria, Illinois, United States, 61615
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, Illinois, United States, 61615
Methodist Medical Center of Illinois
Peoria, Illinois, United States, 61636
OSF Saint Francis Medical Center
Peoria, Illinois, United States, 61637
Illinois CancerCare-Peru
Peru, Illinois, United States, 61354
Valley Radiation Oncology
Peru, Illinois, United States, 61354
Edward Hospital/Cancer Center?Plainfield
Plainfield, Illinois, United States, 60585
Illinois CancerCare-Princeton
Princeton, Illinois, United States, 61356
West Suburban Medical Center
River Forest, Illinois, United States, 60305
SwedishAmerican Regional Cancer Center/ACT
Rockford, Illinois, United States, 61114
Central Illinois Hematology Oncology Center
Springfield, Illinois, United States, 62702
Southern Illinois University School of Medicine
Springfield, Illinois, United States, 62702
Springfield Clinic
Springfield, Illinois, United States, 62702
Memorial Medical Center
Springfield, Illinois, United States, 62781
Carle Cancer Center
Urbana, Illinois, United States, 61801
The Carle Foundation Hospital
Urbana, Illinois, United States, 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States, 60555
Rush-Copley Healthcare Center
Yorkville, Illinois, United States, 60560
United States, Indiana
IU Health North Hospital
Carmel, Indiana, United States, 46032
IU Health Central Indiana Cancer Centers-Fishers
Fishers, Indiana, United States, 46037
Fort Wayne Medical Oncology and Hematology Inc-Parkview
Fort Wayne, Indiana, United States, 46845
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, United States, 46202
IU Health Methodist Hospital
Indianapolis, Indiana, United States, 46202
Sidney and Lois Eskenazi Hospital
Indianapolis, Indiana, United States, 46202
IU Health Central Indiana Cancer Centers-East
Indianapolis, Indiana, United States, 46219
Franciscan Health Indianapolis
Indianapolis, Indiana, United States, 46237
Springmill Medical Center
Indianapolis, Indiana, United States, 46290
IU Health Arnett Cancer Care
Lafayette, Indiana, United States, 47904
Woodland Cancer Care Center
Michigan City, Indiana, United States, 46360
Franciscan Health Mooresville
Mooresville, Indiana, United States, 46158
IU Health Ball Memorial Hospital
Muncie, Indiana, United States, 47303
Reid Health
Richmond, Indiana, United States, 47374
Union Hospital
Terre Haute, Indiana, United States, 47804
United States, Iowa
Mary Greeley Medical Center
Ames, Iowa, United States, 50010
McFarland Clinic PC - Ames
Ames, Iowa, United States, 50010
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa, United States, 52722
McFarland Clinic PC-Boone
Boone, Iowa, United States, 50036
Mercy Hospital
Cedar Rapids, Iowa, United States, 52403
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, United States, 52403
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa, United States, 50325
Mercy Cancer Center-West Lakes
Clive, Iowa, United States, 50325
Alegent Health Mercy Hospital
Council Bluffs, Iowa, United States, 51503
Genesis Medical Center - East Campus
Davenport, Iowa, United States, 52803
Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, United States, 50309
Broadlawns Medical Center
Des Moines, Iowa, United States, 50314
Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa, United States, 50314
Mercy Medical Center - Des Moines
Des Moines, Iowa, United States, 50314
McFarland Clinic PC-Trinity Cancer Center
Fort Dodge, Iowa, United States, 50501
Trinity Regional Medical Center
Fort Dodge, Iowa, United States, 50501
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, United States, 52242
McFarland Clinic PC-Jefferson
Jefferson, Iowa, United States, 50129
McFarland Clinic PC-Marshalltown
Marshalltown, Iowa, United States, 50158
Mercy Medical Center - North Iowa
Mason City, Iowa, United States, 50401
Siouxland Regional Cancer Center
Sioux City, Iowa, United States, 51101
Mercy Medical Center-West Lakes
West Des Moines, Iowa, United States, 50266
United States, Kansas
Cancer Center of Kansas - Chanute
Chanute, Kansas, United States, 66720
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, United States, 67801
Cancer Center of Kansas - El Dorado
El Dorado, Kansas, United States, 67042
Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas, United States, 66701
Saint Catherine Hospital
Garden City, Kansas, United States, 67846
Central Care Cancer Center - Great Bend
Great Bend, Kansas, United States, 67530
Saint Rose Ambulatory and Surgery Center
Great Bend, Kansas, United States, 67530
Hays Medical Center
Hays, Kansas, United States, 67601
Cancer Center of Kansas-Independence
Independence, Kansas, United States, 67301
University of Kansas Cancer Center-West
Kansas City, Kansas, United States, 66112
Cancer Center of Kansas-Kingman
Kingman, Kansas, United States, 67068
Lawrence Memorial Hospital
Lawrence, Kansas, United States, 66044
Kansas Institute of Medicine Cancer and Blood Center
Lenexa, Kansas, United States, 66219
Minimally Invasive Surgery Hospital
Lenexa, Kansas, United States, 66219
Cancer Center of Kansas-Liberal
Liberal, Kansas, United States, 67905
Cancer Center of Kansas-Manhattan
Manhattan, Kansas, United States, 66502
Cancer Center of Kansas - McPherson
McPherson, Kansas, United States, 67460
Cancer Center of Kansas - Newton
Newton, Kansas, United States, 67114
Olathe Medical Center
Olathe, Kansas, United States, 66061
Menorah Medical Center
Overland Park, Kansas, United States, 66209
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, United States, 66210
Cancer Center of Kansas - Parsons
Parsons, Kansas, United States, 67357
Cancer Center of Kansas - Pratt
Pratt, Kansas, United States, 67124
Cancer Center of Kansas - Salina
Salina, Kansas, United States, 67401
Salina Regional Health Center
Salina, Kansas, United States, 67401
Saint Francis Hospital and Medical Center - Topeka
Topeka, Kansas, United States, 66606
Cancer Center of Kansas - Wellington
Wellington, Kansas, United States, 67152
Associates In Womens Health
Wichita, Kansas, United States, 67208
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas, United States, 67208
Ascension Via Christi Hospitals Wichita
Wichita, Kansas, United States, 67214
Cancer Center of Kansas - Wichita
Wichita, Kansas, United States, 67214
Cancer Center of Kansas - Winfield
Winfield, Kansas, United States, 67156
United States, Kentucky
Flaget Memorial Hospital
Bardstown, Kentucky, United States, 40004
Baptist Health Corbin
Corbin, Kentucky, United States, 40701
Oncology Hematology Care Inc-Crestview
Crestview Hills, Kentucky, United States, 41017
Saint Elizabeth Medical Center South
Edgewood, Kentucky, United States, 41017
Hardin Memorial Hospital
Elizabethtown, Kentucky, United States, 42701
Saint Elizabeth Fort Thomas
Fort Thomas, Kentucky, United States, 41075
Baptist Health Lexington
Lexington, Kentucky, United States, 40503
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, United States, 40504
Saint Joseph Hospital East
Lexington, Kentucky, United States, 40509
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, United States, 40536
Jewish Hospital
Louisville, Kentucky, United States, 40202
Baptist Health Louisville
Louisville, Kentucky, United States, 40207
Jewish Hospital Medical Center Northeast
Louisville, Kentucky, United States, 40245
Baptist Health Madisonville/Merle Mahr Cancer Center
Madisonville, Kentucky, United States, 42431
Baptist Health Paducah
Paducah, Kentucky, United States, 42003
United States, Louisiana
LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana, United States, 70805
Hematology/Oncology Clinic LLP
Baton Rouge, Louisiana, United States, 70809
Louisiana Hematology Oncology Associates LLC
Baton Rouge, Louisiana, United States, 70809
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States, 70809
Ochsner Health Center-Summa
Baton Rouge, Louisiana, United States, 70809
Our Lady of the Lake Physicians Group - Medical Oncology
Baton Rouge, Louisiana, United States, 70809
Medical Center of Baton Rouge
Baton Rouge, Louisiana, United States, 70816
Mary Bird Perkins Cancer Center - Covington
Covington, Louisiana, United States, 70433
Northshore Oncology Associates-Covington
Covington, Louisiana, United States, 70433
Mary Bird Perkins Cancer Center - Houma
Houma, Louisiana, United States, 70360
Oncology Center of The South Incorporated
Houma, Louisiana, United States, 70360
Louisiana State University Health Science Center
New Orleans, Louisiana, United States, 70112
University Medical Center New Orleans
New Orleans, Louisiana, United States, 70112
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States, 70121
United States, Maine
Harold Alfond Center for Cancer Care
Augusta, Maine, United States, 04330
Eastern Maine Medical Center
Bangor, Maine, United States, 04401
Lafayette Family Cancer Center-EMMC
Brewer, Maine, United States, 04412
Penobscot Bay Medical Center
Rockport, Maine, United States, 04856
York Hospital
York, Maine, United States, 03909
United States, Maryland
Anne Arundel Medical Center
Annapolis, Maryland, United States, 21401
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, United States, 21201
Greater Baltimore Medical Center
Baltimore, Maryland, United States, 21204
Sinai Hospital of Baltimore
Baltimore, Maryland, United States, 21215
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore, Maryland, United States, 21237
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, United States, 21287
UM Upper Chesapeake Medical Center
Bel Air, Maryland, United States, 21014
Western Maryland Regional Medical Center
Cumberland, Maryland, United States, 21502
University of Maryland Shore Medical Center at Easton
Easton, Maryland, United States, 21601
MedStar Montgomery Medical Center
Olney, Maryland, United States, 20832
Northwest Hospital Center
Randallstown, Maryland, United States, 21133
United States, Massachusetts
Beverly Hospital
Beverly, Massachusetts, United States, 01915
Lahey Hospital and Medical Center
Burlington, Massachusetts, United States, 01805
Saint Anne's Hospital
Fall River, Massachusetts, United States, 02721
Addison Gilbert Hospital
Gloucester, Massachusetts, United States, 01930
Newton-Wellesley Hospital
Newton, Massachusetts, United States, 02462
Berkshire Medical Center - Cancer Center
Pittsfield, Massachusetts, United States, 01201
Winchester Hospital
Winchester, Massachusetts, United States, 01890
UMass Memorial Medical Center - University Campus
Worcester, Massachusetts, United States, 01655
United States, Michigan
Hickman Cancer Center
Adrian, Michigan, United States, 49221
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, United States, 48106
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, United States, 48183
IHA Hematology Oncology Consultants-Chelsea
Chelsea, Michigan, United States, 48118
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, United States, 48038
Beaumont Hospital - Dearborn
Dearborn, Michigan, United States, 48124
Henry Ford Medical Center-Fairlane
Dearborn, Michigan, United States, 48126
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Ascension Saint John Hospital
Detroit, Michigan, United States, 48236
Green Bay Oncology - Escanaba
Escanaba, Michigan, United States, 49829
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, United States, 48334
Genesys Hurley Cancer Institute
Flint, Michigan, United States, 48503
Hurley Medical Center
Flint, Michigan, United States, 48503
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, United States, 49503
William Beaumont Hospital-Grosse Point
Grosse Pointe, Michigan, United States, 48230
Green Bay Oncology - Iron Mountain
Iron Mountain, Michigan, United States, 49801
Allegiance Health
Jackson, Michigan, United States, 49201
West Michigan Cancer Center
Kalamazoo, Michigan, United States, 49007
Borgess Medical Center
Kalamazoo, Michigan, United States, 49048
Saint Mary Mercy Hospital
Livonia, Michigan, United States, 48154
Henry Ford Medical Center-Columbus
Novi, Michigan, United States, 48377
Saint Joseph Mercy Oakland
Pontiac, Michigan, United States, 48341
Lake Huron Medical Center
Port Huron, Michigan, United States, 48060
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan, United States, 48073
Ascension Saint Mary's Hospital
Saginaw, Michigan, United States, 48601
William Beaumont Hospital - Troy
Troy, Michigan, United States, 48085
Saint John Macomb-Oakland Hospital
Warren, Michigan, United States, 48093
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, United States, 48322
United States, Minnesota
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, United States, 56601
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota, United States, 56401
Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
Essentia Health Cancer Center
Duluth, Minnesota, United States, 55805
Lake Region Healthcare Corporation-Cancer Care
Fergus Falls, Minnesota, United States, 56537
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, United States, 55109
Saint John's Hospital - Healtheast
Maplewood, Minnesota, United States, 55109
Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Health Partners Inc
Minneapolis, Minnesota, United States, 55454
New Ulm Medical Center
New Ulm, Minnesota, United States, 56073
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, United States, 56303
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Lakeview Hospital
Stillwater, Minnesota, United States, 55082
Rice Memorial Hospital
Willmar, Minnesota, United States, 56201
United States, Mississippi
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi, United States, 39705
Baptist Cancer Center-Grenada
Grenada, Mississippi, United States, 38901
Hattiesburg Clinic - Hematology/Oncology Clinic
Hattiesburg, Mississippi, United States, 39401
Forrest General Hospital / Cancer Center
Hattiesburg, Mississippi, United States, 39404
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi, United States, 38652
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi, United States, 38655
Singing River Hospital
Pascagoula, Mississippi, United States, 39581
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi, United States, 38671
United States, Missouri
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri, United States, 63011
Parkland Health Center-Bonne Terre
Bonne Terre, Missouri, United States, 63628
Cox Cancer Center Branson
Branson, Missouri, United States, 65616
Saint Francis Medical Center
Cape Girardeau, Missouri, United States, 63703
Southeast Cancer Center
Cape Girardeau, Missouri, United States, 63703
Saint Luke's Hospital
Chesterfield, Missouri, United States, 63017
University of Missouri - Ellis Fischel
Columbia, Missouri, United States, 65212
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States, 63141
Centerpoint Medical Center LLC
Independence, Missouri, United States, 64057
Capital Region Southwest Campus
Jefferson City, Missouri, United States, 65109
Truman Medical Center
Kansas City, Missouri, United States, 64108
The University of Kansas Cancer Center-South
Kansas City, Missouri, United States, 64131
Research Medical Center
Kansas City, Missouri, United States, 64132
The University of Kansas Cancer Center-North
Kansas City, Missouri, United States, 64154
The University of Kansas Cancer Center-Lee's Summit
Lee's Summit, Missouri, United States, 64064
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri, United States, 63109
Washington University School of Medicine
Saint Louis, Missouri, United States, 63110
Missouri Baptist Medical Center
Saint Louis, Missouri, United States, 63131
Mercy Hospital Saint Louis
Saint Louis, Missouri, United States, 63141
Siteman Cancer Center at Saint Peters Hospital
Saint Peters, Missouri, United States, 63376
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, United States, 63670
Mercy Hospital Springfield
Springfield, Missouri, United States, 65804
CoxHealth South Hospital
Springfield, Missouri, United States, 65807
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, United States, 63080
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri, United States, 63127
United States, Montana
Saint Vincent Healthcare
Billings, Montana, United States, 59101
Bozeman Deaconess Hospital
Bozeman, Montana, United States, 59715
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana, United States, 59701
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana, United States, 59405
Saint Peter's Community Hospital
Helena, Montana, United States, 59601
Kalispell Regional Medical Center
Kalispell, Montana, United States, 59901
Saint Patrick Hospital - Community Hospital
Missoula, Montana, United States, 59802
United States, Nebraska
CHI Health Saint Francis
Grand Island, Nebraska, United States, 68803
CHI Health Good Samaritan
Kearney, Nebraska, United States, 68847
Alegent Health Immanuel Medical Center
Omaha, Nebraska, United States, 68122
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, United States, 68124
Alegent Health Lakeside Hospital
Omaha, Nebraska, United States, 68130
Creighton University Medical Center
Omaha, Nebraska, United States, 68131
United States, New Hampshire
Wentworth-Douglass Hospital
Dover, New Hampshire, United States, 03820
Cheshire Medical Center-Dartmouth-Hitchcock Keene
Keene, New Hampshire, United States, 03431
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Norris Cotton Cancer Center-Manchester
Manchester, New Hampshire, United States, 03102
Saint Joseph Hospital
Nashua, New Hampshire, United States, 03060
Norris Cotton Cancer Center-Nashua
Nashua, New Hampshire, United States, 03063
United States, New Jersey
AtlantiCare Health Park-Cape May Court House
Cape May Court House, New Jersey, United States, 08210
AtlantiCare Surgery Center
Egg Harbor Township, New Jersey, United States, 08234
Englewood Hospital and Medical Center
Englewood, New Jersey, United States, 07631
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
The Cancer Institute of New Jersey Hamilton
Hamilton, New Jersey, United States, 08690
Monmouth Medical Center
Long Branch, New Jersey, United States, 07740
Virtua Memorial
Mount Holly, New Jersey, United States, 08060
Jersey Shore Medical Center
Neptune, New Jersey, United States, 07753
Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey, United States, 08876
Inspira Medical Center Vineland
Vineland, New Jersey, United States, 08360
Virtua Voorhees
Voorhees, New Jersey, United States, 08043
Inspira Medical Center Woodbury
Woodbury, New Jersey, United States, 08096
United States, New Mexico
University of New Mexico Cancer Center
Albuquerque, New Mexico, United States, 87102
New Mexico Oncology Hematology Consultants
Albuquerque, New Mexico, United States, 87109
Presbyterian Kaseman Hospital
Albuquerque, New Mexico, United States, 87110
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico, United States, 88011
Christus Saint Vincent Regional Cancer Center
Santa Fe, New Mexico, United States, 87505
United States, New York
Hematology Oncology Associates of Central New York-Auburn
Auburn, New York, United States, 13021
Montefiore Medical Center-Einstein Campus
Bronx, New York, United States, 10461
Montefiore Medical Center-Weiler Hospital
Bronx, New York, United States, 10461
Montefiore Medical Center - Moses Campus
Bronx, New York, United States, 10467
Kings County Hospital
Brooklyn, New York, United States, 11203
State University of New York Downstate Medical Center
Brooklyn, New York, United States, 11203
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York, United States, 13057
Arnot Ogden Medical Center/Falck Cancer Center
Elmira, New York, United States, 14905
Mount Sinai Union Square
New York, New York, United States, 10003
Mount Sinai West
New York, New York, United States, 10019
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, United States, 10032
NYP/Weill Cornell Medical Center
New York, New York, United States, 10065
University of Rochester
Rochester, New York, United States, 14642
Staten Island University Hospital
Staten Island, New York, United States, 10305
Hematology Oncology Associates of Central New York-Onondaga Hill
Syracuse, New York, United States, 13215
Dickstein Cancer Treatment Center
White Plains, New York, United States, 10601
United States, North Carolina
Randolph Hospital
Asheboro, North Carolina, United States, 27203
Cancer Care of Western North Carolina
Asheville, North Carolina, United States, 28801
Mission Hospital
Asheville, North Carolina, United States, 28801
Hope Women's Cancer Centers-Asheville
Asheville, North Carolina, United States, 28816
Cone Health Cancer Center at Alamance Regional
Burlington, North Carolina, United States, 27215
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina, United States, 28328
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina, United States, 27534
Wayne Memorial Hospital
Goldsboro, North Carolina, United States, 27534
Cone Health Cancer Center
Greensboro, North Carolina, United States, 27403
Hendersonville Hematology and Oncology at Pardee
Hendersonville, North Carolina, United States, 28791
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina, United States, 28791
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina, United States, 28546
Vidant Oncology-Kinston
Kinston, North Carolina, United States, 28501
Cone Heath Cancer Center at Mebane
Mebane, North Carolina, United States, 27302
Annie Penn Memorial Hospital
Reidsville, North Carolina, United States, 27320
Marion L Shepard Cancer Center at Vidant Beaufort Hospital
Washington, North Carolina, United States, 27889
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
United States, North Dakota
Sanford Bismarck Medical Center
Bismarck, North Dakota, United States, 58501
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota, United States, 58103
Sanford Broadway Medical Center
Fargo, North Dakota, United States, 58122
Sanford Clinic North-Fargo
Fargo, North Dakota, United States, 58122
Sanford Roger Maris Cancer Center
Fargo, North Dakota, United States, 58122
Altru Cancer Center
Grand Forks, North Dakota, United States, 58201
Trinity Cancer Care Center
Minot, North Dakota, United States, 58701
United States, Ohio
Summa Health System - Akron Campus
Akron, Ohio, United States, 44304
Cleveland Clinic Akron General
Akron, Ohio, United States, 44307
Strecker Cancer Center-Belpre
Belpre, Ohio, United States, 45714
Toledo Clinic Cancer Centers-Bowling Green
Bowling Green, Ohio, United States, 43402
Adena Regional Medical Center
Chillicothe, Ohio, United States, 45601
Oncology Hematology Care Inc-Eden Park
Cincinnati, Ohio, United States, 45202
Oncology Hematology Care Inc-Mercy West
Cincinnati, Ohio, United States, 45211
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, United States, 45220
Oncology Hematology Care Inc - Anderson
Cincinnati, Ohio, United States, 45230
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio, United States, 45236
Bethesda North Hospital
Cincinnati, Ohio, United States, 45242
Oncology Hematology Care Inc-Blue Ash
Cincinnati, Ohio, United States, 45242
TriHealth Cancer Institute-Westside
Cincinnati, Ohio, United States, 45247
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio, United States, 45255
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio, United States, 44111
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210
Mount Carmel East Hospital
Columbus, Ohio, United States, 43213
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, United States, 43214
Riverside Methodist Hospital
Columbus, Ohio, United States, 43214
Grant Medical Center
Columbus, Ohio, United States, 43215
The Mark H Zangmeister Center
Columbus, Ohio, United States, 43219
Mount Carmel Health Center West
Columbus, Ohio, United States, 43222
Doctors Hospital
Columbus, Ohio, United States, 43228
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, United States, 43015
Delaware Radiation Oncology
Delaware, Ohio, United States, 43015
Grady Memorial Hospital
Delaware, Ohio, United States, 43015
Oncology Hematology Care Inc-Healthplex
Fairfield, Ohio, United States, 45014
Cleveland Clinic Cancer Center Independence
Independence, Ohio, United States, 44131
Fairfield Medical Center
Lancaster, Ohio, United States, 43130
Saint Rita's Medical Center
Lima, Ohio, United States, 45801
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio, United States, 44906
Marietta Memorial Hospital
Marietta, Ohio, United States, 45750
OhioHealth Marion General Hospital
Marion, Ohio, United States, 43302
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio, United States, 43537
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, United States, 44124
Knox Community Hospital
Mount Vernon, Ohio, United States, 43050
Licking Memorial Hospital
Newark, Ohio, United States, 43055
Newark Radiation Oncology
Newark, Ohio, United States, 43055
Saint Charles Hospital
Oregon, Ohio, United States, 43616
Toledo Clinic Cancer Centers-Oregon
Oregon, Ohio, United States, 43616
Mercy Health Perrysburg Cancer Center
Perrysburg, Ohio, United States, 43551
Southern Ohio Medical Center
Portsmouth, Ohio, United States, 45662
North Coast Cancer Care
Sandusky, Ohio, United States, 44870
Springfield Regional Cancer Center
Springfield, Ohio, United States, 45504
Springfield Regional Medical Center
Springfield, Ohio, United States, 45505
Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio, United States, 44136
ProMedica Flower Hospital
Sylvania, Ohio, United States, 43560
Toledo Community Hospital Oncology Program CCOP
Toledo, Ohio, United States, 43617
Mercy Saint Anne Hospital
Toledo, Ohio, United States, 43623
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio, United States, 43623
Upper Valley Medical Center
Troy, Ohio, United States, 45373
South Pointe Hospital
Warrensville Heights, Ohio, United States, 44122
Saint Ann's Hospital
Westerville, Ohio, United States, 43081
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio, United States, 44691
Wright-Patterson Medical Center
Wright-Patterson Air Force Base, Ohio, United States, 45433-5529
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio, United States, 43701
United States, Oklahoma
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma, United States, 73505
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
United States, Oregon
Saint Charles Health System
Bend, Oregon, United States, 97701
Providence Oncology and Hematology Care Southeast
Clackamas, Oregon, United States, 97015
Bay Area Hospital
Coos Bay, Oregon, United States, 97420
Rogue Valley Medical Center
Medford, Oregon, United States, 97504
Providence Newberg Medical Center
Newberg, Oregon, United States, 97132
Providence Willamette Falls Medical Center
Oregon City, Oregon, United States, 97045
Providence Portland Medical Center
Portland, Oregon, United States, 97213
Providence Saint Vincent Medical Center
Portland, Oregon, United States, 97225
United States, Pennsylvania
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, United States, 19010
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, United States, 19317
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Doylestown Hospital
Doylestown, Pennsylvania, United States, 18901
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania, United States, 17109
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, United States, 18201
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, United States, 17033-0850
Jefferson Hospital
Jefferson Hills, Pennsylvania, United States, 15025
Lancaster General Hospital
Lancaster, Pennsylvania, United States, 17604
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, United States, 17837
Lewistown Hospital
Lewistown, Pennsylvania, United States, 17044
Riddle Memorial Hospital
Media, Pennsylvania, United States, 19063
Forbes Hospital
Monroeville, Pennsylvania, United States, 15146
Allegheny Valley Hospital
Natrona Heights, Pennsylvania, United States, 15065
Paoli Memorial Hospital
Paoli, Pennsylvania, United States, 19301
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
Temple University Hospital
Philadelphia, Pennsylvania, United States, 19140
Einstein Medical Center Philadelphia
Philadelphia, Pennsylvania, United States, 19141
Phoenixville Hospital
Phoenixville, Pennsylvania, United States, 19460
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
West Penn Hospital
Pittsburgh, Pennsylvania, United States, 15224
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, United States, 15232
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania, United States, 17901
Penn State Health Saint Joseph Medical Center
Reading, Pennsylvania, United States, 19605
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania, United States, 18840
Geisinger Medical Group
State College, Pennsylvania, United States, 16801
Mount Nittany Medical Center
State College, Pennsylvania, United States, 16803
Chester County Hospital
West Chester, Pennsylvania, United States, 19380
Reading Hospital
West Reading, Pennsylvania, United States, 19611
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania, United States, 15090
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, United States, 18711
UPMC Susquehanna
Williamsport, Pennsylvania, United States, 17701
Lankenau Medical Center
Wynnewood, Pennsylvania, United States, 19096
United States, Rhode Island
Women and Infants Hospital
Providence, Rhode Island, United States, 02905
United States, South Carolina
AnMed Health Cancer Center
Anderson, South Carolina, United States, 29621
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Prisma Health Cancer Institute - Easley
Easley, South Carolina, United States, 29640
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina, United States, 29341
Saint Francis Hospital
Greenville, South Carolina, United States, 29601
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, United States, 29605
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, United States, 29605
Saint Francis Cancer Center
Greenville, South Carolina, United States, 29607
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, United States, 29615
Prisma Health Cancer Institute - Greer
Greer, South Carolina, United States, 29650
Gibbs Cancer Center-Pelham
Greer, South Carolina, United States, 29651
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, United States, 29672
Spartanburg Medical Center
Spartanburg, South Carolina, United States, 29303
Prisma Health Cancer Institute - Spartanburg
Spartanburg, South Carolina, United States, 29307
United States, South Dakota
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota, United States, 57401
Rapid City Regional Hospital
Rapid City, South Dakota, United States, 57701
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, United States, 57104
Avera Cancer Institute
Sioux Falls, South Dakota, United States, 57105
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, United States, 57117-5134
United States, Tennessee
Jackson-Madison County General Hospital
Jackson, Tennessee, United States, 38301
Regional Cancer Center at Indian Path Community Hospital
Kingsport, Tennessee, United States, 37660
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee, United States, 37660
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, United States, 38120
Baptist Memorial Hospital for Women
Memphis, Tennessee, United States, 38120
Family Cancer Center-Memphis
Memphis, Tennessee, United States, 38120
Meharry Medical College
Nashville, Tennessee, United States, 37208
United States, Texas
Hendrick Medical Center
Abilene, Texas, United States, 79601
Parkland Memorial Hospital
Dallas, Texas, United States, 75235
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, United States, 75390
Texas Tech University Health Sciences Center-El Paso
El Paso, Texas, United States, 79905
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas, United States, 76104
University of Texas Health Science Center at Tyler
Tyler, Texas, United States, 75708
United States, Vermont
Norris Cotton Cancer Center-North
Saint Johnsbury, Vermont, United States, 05819
United States, Virginia
University of Virginia Cancer Center
Charlottesville, Virginia, United States, 22908
Hematology Oncology Associates of Fredericksburg Inc
Fredericksburg, Virginia, United States, 22408
Centra Lynchburg Hematology-Oncology Clinic Inc
Lynchburg, Virginia, United States, 24501
Sovah Health Martinsville
Martinsville, Virginia, United States, 24115
Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia, United States, 23116
Bon Secours Saint Francis Medical Center
Midlothian, Virginia, United States, 23114
Southwest VA Regional Cancer Center
Norton, Virginia, United States, 24273
Bon Secours Saint Mary's Hospital
Richmond, Virginia, United States, 23226
Virginia Cancer Institute
Richmond, Virginia, United States, 23230
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, United States, 23298
VCU Community Memorial Health Center
South Hill, Virginia, United States, 23970
Shenandoah Oncology PC
Winchester, Virginia, United States, 22601
United States, Washington
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, Washington, United States, 98310
Harrison Medical Center
Bremerton, Washington, United States, 98310
Highline Medical Center-Main Campus
Burien, Washington, United States, 98166
Swedish Cancer Institute-Edmonds
Edmonds, Washington, United States, 98026
Swedish Cancer Institute-Issaquah
Issaquah, Washington, United States, 98029
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, United States, 99336
Seattle Cancer Care Alliance at EvergreenHealth
Kirkland, Washington, United States, 98034
PeaceHealth Saint John Medical Center
Longview, Washington, United States, 98632
Skagit Valley Hospital Regional Cancer Care Center
Mount Vernon, Washington, United States, 98274
Skagit Valley Hospital
Mount Vernon, Washington, United States, 98274
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo, Washington, United States, 98370
Minor and James Medical PLLC
Seattle, Washington, United States, 98104
Swedish Medical Center-Ballard Campus
Seattle, Washington, United States, 98107
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109
Seattle Cancer Care Alliance
Seattle, Washington, United States, 98109
Kaiser Permanente Washington
Seattle, Washington, United States, 98112
Swedish Medical Center-First Hill
Seattle, Washington, United States, 98122-4307
University of Washington Medical Center
Seattle, Washington, United States, 98195
Franciscan Research Center-Northwest Medical Plaza
Tacoma, Washington, United States, 98405
Northwest Medical Specialties PLLC
Tacoma, Washington, United States, 98405
PeaceHealth Southwest Medical Center
Vancouver, Washington, United States, 98664
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, United States, 99362
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, United States, 98902
United States, West Virginia
West Virginia University Charleston Division
Charleston, West Virginia, United States, 25304
Edwards Comprehensive Cancer Center
Huntington, West Virginia, United States, 25701
West Virginia University Healthcare
Morgantown, West Virginia, United States, 26506
United States, Wisconsin
Langlade Hospital and Cancer Center
Antigo, Wisconsin, United States, 54409
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, United States, 53105
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin, United States, 54729
Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire, Wisconsin, United States, 54701
Aurora Health Center-Fond du Lac
Fond Du Lac, Wisconsin, United States, 54937
Aurora Health Care Germantown Health Center
Germantown, Wisconsin, United States, 53022
Aurora Cancer Care-Grafton
Grafton, Wisconsin, United States, 53024
Green Bay Oncology at Saint Vincent Hospital
Green Bay, Wisconsin, United States, 54301-3526
Bellin Memorial Hospital
Green Bay, Wisconsin, United States, 54301
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, United States, 54301
Green Bay Oncology Limited at Saint Mary's Hospital
Green Bay, Wisconsin, United States, 54303
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, United States, 54303
Aurora BayCare Medical Center
Green Bay, Wisconsin, United States, 54311
Mercyhealth Hospital and Cancer Center - Janesville
Janesville, Wisconsin, United States, 53548
UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin, United States, 53038
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, United States, 53142
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States, 54601
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States, 53792
Holy Family Memorial Hospital
Manitowoc, Wisconsin, United States, 54221
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, United States, 54143
Saint Vincent Hospital Cancer Center at Marinette
Marinette, Wisconsin, United States, 54143
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, United States, 54449
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin, United States, 53209
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, United States, 53215
Aurora Sinai Medical Center
Milwaukee, Wisconsin, United States, 53233
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin, United States, 54548
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, United States, 53149
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, United States, 54017
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, United States, 53066
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin, United States, 54154
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, United States, 54904
Ascension All Saints Hospital
Racine, Wisconsin, United States, 53405
Aurora Cancer Care-Racine
Racine, Wisconsin, United States, 53406
Ascension Saint Mary's Hospital
Rhinelander, Wisconsin, United States, 54501
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, United States, 54868
HSHS Saint Nicholas Hospital
Sheboygan, Wisconsin, United States, 53081
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, United States, 53081
Ascension Saint Michael's Hospital
Stevens Point, Wisconsin, United States, 54481
Marshfield Clinic Stevens Point Center
Stevens Point, Wisconsin, United States, 54482
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, United States, 54235-1495
Green Bay Oncology - Sturgeon Bay
Sturgeon Bay, Wisconsin, United States, 54235
Aurora Medical Center in Summit
Summit, Wisconsin, United States, 53066
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, United States, 54241
Aurora Cancer Care-Waukesha
Waukesha, Wisconsin, United States, 53188
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin, United States, 53188
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, United States, 53188
Aspirus Regional Cancer Center
Wausau, Wisconsin, United States, 54401
Marshfield Clinic-Wausau Center
Wausau, Wisconsin, United States, 54401
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, United States, 53226
Aurora West Allis Medical Center
West Allis, Wisconsin, United States, 53227
Marshfield Clinic - Weston Center
Weston, Wisconsin, United States, 54476
Aspirus UW Cancer Center
Wisconsin Rapids, Wisconsin, United States, 54494
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, United States, 54494
United States, Wyoming
Cheyenne Regional Medical Center-West
Cheyenne, Wyoming, United States, 82001
South Africa
University Of Pretoria
Pretoria, South Africa, 0002
Sponsors and Collaborators
National Cancer Institute (NCI)
Investigators
Layout table for investigator information
Principal Investigator: Roisin M Connolly ECOG-ACRIN Cancer Research Group

Layout table for additonal information
Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT02115282     History of Changes
Other Study ID Numbers: NCI-2014-00746
NCI-2014-00746 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
ECOG-E2112
E2112 ( Other Identifier: ECOG-ACRIN Cancer Research Group )
E2112 ( Other Identifier: CTEP )
U10CA180820 ( U.S. NIH Grant/Contract )
U10CA021115 ( U.S. NIH Grant/Contract )
U24CA196172 ( U.S. NIH Grant/Contract )
First Posted: April 16, 2014    Key Record Dates
Last Update Posted: November 8, 2019
Last Verified: July 2019
Additional relevant MeSH terms:
Layout table for MeSH terms
Carcinoma
Breast Neoplasms
Adenocarcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
Exemestane
Goserelin
Entinostat
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Antineoplastic Agents
Aromatase Inhibitors
Steroid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Estrogen Antagonists
Hormone Antagonists
Antineoplastic Agents, Hormonal
Histone Deacetylase Inhibitors