Cognitive Stimulation Study (CogStim)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT02067689 |
Recruitment Status :
Completed
First Posted : February 20, 2014
Last Update Posted : January 28, 2020
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Condition or disease | Intervention/treatment | Phase |
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Healthy | Device: Transcranial Direct Current Stimulation | Not Applicable |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 18 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Single (Participant) |
Primary Purpose: | Basic Science |
Official Title: | Neuromodulation of Cognitive Function Using Transcranial Direct Current Stimulation |
Actual Study Start Date : | January 2016 |
Actual Primary Completion Date : | May 10, 2019 |
Actual Study Completion Date : | May 10, 2019 |
Arm | Intervention/treatment |
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Experimental: Hemisphere Stimulation
Participants will receive 1mA vs. 2mA transcranial direct current stimulation of a) right and b) left brain structures (1x1 stimulation), and sham/placebo stimulation. A subset of participants will undergo right and left brain stimulation, but all will undergo sham stimulation.
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Device: Transcranial Direct Current Stimulation
Application of a weak electrical current to the scalp
Other Names:
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Experimental: Temporal Lobe Stimulation
A group of participants will undergo 1x1 transcranial direct current stimulation of the temporal lobes at 1 mA vs. 2 mA vs. sham stimulation. A second group of participants will undergo 1mA or 2mA stimulation, and sham, in right vs. left structures using 4x1 stimulation (e.g., 1mA left temporal, 1mA right temporal, sham; 2mA left temporal, 2mA right temporal, sham).
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Device: Transcranial Direct Current Stimulation
Application of a weak electrical current to the scalp
Other Names:
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Experimental: Frontal Lobe Stimulation
A group of participants will undergo 1x1 transcranial direct current stimulation of the frontal lobes at 1 mA vs. 2 mA vs. sham stimulation. A second group of participants will undergo 1mA or 2mA stimulation, and sham, in right vs. left frontal structures using 4x1 stimulation (e.g., 1mA left frontal, 1mA right frontal, sham; 2mA left frontal, 2mA right frontal, sham).
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Device: Transcranial Direct Current Stimulation
Application of a weak electrical current to the scalp
Other Names:
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Experimental: Parietal Lobe Stimulation
A group of participants will undergo 1x1 transcranial direct current stimulation of the parietal lobes at 1 mA vs. 2 mA vs. sham stimulation. A second group of participants will undergo 1mA or 2mA stimulation, and sham, in right vs. left parietal lobes using 4x1 stimulation (e.g., 1mA left parietal lobes, 1mA right parietal lobes, sham; 2mA parietal lobes, 2mA right parietal lobes, sham).
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Device: Transcranial Direct Current Stimulation
Application of a weak electrical current to the scalp
Other Names:
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Experimental: Supplementary Motor Stimulation
A group of participants will undergo 1x1 transcranial direct current stimulation of the Supplementary Motor Area at 1mA vs. 2mA vs. sham stimulation. A second group of participants will undergo 1mA or 2mA stimulation, and sham, in right vs. left Supplementary Motor Area using 4x1 stimulation (e.g., 1mA left Supplementary Motor Area, 1mA right Supplementary Motor Area, sham; 2mA left Supplementary Motor Area, 2mA right Supplementary Motor Area, sham).
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Device: Transcranial Direct Current Stimulation
Application of a weak electrical current to the scalp
Other Names:
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Experimental: Brain Structure Interactions Group
This cohort will evaluate the interaction between frontal, parietal, temporal, and SMA regions in cognitive function. To accomplish this goal will require evaluation of change in cognitive and neurocognitive performance following transcranial direct current stimulation of different brain regions within the same subjects. For example, we will evaluate the contribution of frontal, SMA, and parietal regions by asking participants to undergo stimulation sessions at each of these sites, in addition to a sham session.
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Device: Transcranial Direct Current Stimulation
Application of a weak electrical current to the scalp
Other Names:
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- NIH Toolbox Scores [ Time Frame: Baseline ]
- NIH Toolbox Scores [ Time Frame: 1 hour after baseline ]

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Ages Eligible for Study: | 18 Years to 90 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Healthy adult
- Eligible to undergo an MRI
Exclusion Criteria:
- History of neurologic disease or dementia
- History of psychiatric disease which required hospitalization, or
- Current depression
- History of head trauma with unconsciousness
- Developmental learning disability (e.g., dyslexia, dyscalculia)
- History of vital organ failure (e.g., heart, lungs, kidneys, liver)
- Currently taking any psycho-active medications
- Pregnancy

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02067689
United States, Florida | |
University of Florida | |
Gainesville, Florida, United States, 32610 |
Principal Investigator: | Adam J Woods, PhD | University of Florida |
Responsible Party: | University of Florida |
ClinicalTrials.gov Identifier: | NCT02067689 |
Other Study ID Numbers: |
IRB201300836 |
First Posted: | February 20, 2014 Key Record Dates |
Last Update Posted: | January 28, 2020 |
Last Verified: | May 2019 |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Product Manufactured in and Exported from the U.S.: | Yes |
Normal cognition in healthy adults Cognitive function Transcranial direct current stimulation Structural Magnetic Resonance Imaging Functional Magnetic Resonance Imaging |