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A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors (CAMELLIA-TIMI)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT02019264
Recruitment Status : Completed
First Posted : December 24, 2013
Last Update Posted : September 6, 2018
Sponsor:
Collaborator:
Thrombolysis In Myocardial Infarction (TIMI) Academic Research Organization
Information provided by (Responsible Party):
Eisai Inc.

Brief Summary:
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study in overweight and obese subjects with CV disease and/or multiple CV risk factors.

Condition or disease Intervention/treatment Phase
Cardiovascular Disease High Cardiovascular Risk Obesity Overweight Type 2 Diabetes Drug: APD356-Lorcaserin hydrochloride Drug: Placebo Phase 4

Detailed Description:
Approximately 12,000 subjects will be randomized to two treatment groups in a ratio of 1:1, stratified by the presence of established CV disease (approximately 80%) or CV risk factors without established CV disease (approximately 20%). Subjects will receive lorcaserin HCl 10 mg BID or placebo BID. The study will consist of 2 phases: Prerandomization and Randomization. The Prerandomization Phase will last up to 30 days and consist of one visit during which subjects will be screened for eligibility. The Randomization Phase will consist of two periods: Treatment and Follow-up. The Treatment Period will last for approximately 5 years with approximately 18 visits and Follow-up period is 30 (+ or - 10 days) from the end of treatment visit.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12000 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
Actual Study Start Date : January 24, 2014
Actual Primary Completion Date : May 14, 2018
Actual Study Completion Date : May 14, 2018

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: APD356 10 mg
APD356 10 mg twice daily
Drug: APD356-Lorcaserin hydrochloride
APD356 10 mg twice daily

Placebo Comparator: Placebo
Placebo twice daily
Drug: Placebo
Placebo twice daily




Primary Outcome Measures :
  1. Time from randomization to first occurrence of Major Adverse Cardiovascular Events (MACE) [ Time Frame: Up to 5 years ]
    MACE events include: myocardial infarction, stroke and cardiovascular (CV) death

  2. Time from randomization to conversion to type 2 diabetes mellitus (T2DM) for subjects without any type of diabetes at Baseline [ Time Frame: Baseline, and specified timepoints up to 5 years ]
  3. Time from randomization to first occurrence of MACE+ [ Time Frame: Up to 5 years ]
    MACE+ events include: myocardial infarction, stroke, CV death, and hospitalization due to unstable angina, heart failure, or any coronary revascularization


Secondary Outcome Measures :
  1. Time from randomization to event of each component of MACE+ [ Time Frame: Up to 5 years ]
  2. Time from randomization to event of all-cause mortality [ Time Frame: Up to 5 years ]
  3. Time from randomization to event of new onset renal impairment or worsening existing renal impairment in subjects with T2DM at Baseline [ Time Frame: Up to 5 years ]
    New onset renal impairment or worsening existing renal impairment include the first occurrence of microalbuminuria, macroalbuminuria, worsening of albuminuria, newly developed CKD, or worsening of CKD, doubling of serum creatinine, or any of the following: ESRD, renal transplant, and renal death.

  4. Time from randomization to event of improvement in renal function [ Time Frame: Up to 5 years ]
  5. Change from Baseline in HbA[1c] at 6 months in subjects with T2DM at Baseline [ Time Frame: Baseline and 6 months ]
  6. The proportion of subjects who meet FDA-defined valvulopathy in echocardiographically determined heart valve changes [ Time Frame: Baseline and 1 year ]
    Comparison between lorcaserin HCl and placebo will be made at 1 year.

  7. The percent change from Baseline in echocardiographically-determined pulmonary arterial systolic pressure [ Time Frame: Baseline and 1 year ]
    Comparison between lorcaserin HCl and placebo will be made at 1 year.

  8. Time to conversion to normal glucose homeostasis [ Time Frame: Baseline and 1 year ]


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Ages Eligible for Study:   40 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria

  1. BMI greater than or equal to 27 kg/m^2
  2. Subjects able and willing to comply with a reduced-calorie diet and an increased physical activity program
  3. Age greater than or equal to 40 years with established CV disease as defined by one of the following:

    1. History of documented MI or ischemic stroke
    2. History of peripheral artery disease
    3. History of revascularization (coronary, carotid, or peripheral artery)
    4. Significant unrevascularized coronary arterial stenosis

OR

Age greater than or equal to 55 years for women or greater than or equal to 50 years for men who have T2DM without established CV disease plus at least one of the following CV risk factors:

  1. Hypertension, or currently receiving therapy for documented hypertension
  2. Dyslipidemia, or currently taking prescription lipid-lowering therapy for documented dyslipidemia
  3. Calculated creatinine clearance greater than or equal to 30 to less than or equal to 60 mL/min per the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation
  4. High hsCRP
  5. Urinary albumin-to-creatinine ratio (ACR) greater than or equal to 30 ug/mg

Subjects with T2DM may have a pre-existing or new diagnosis of T2DM. A new diagnosis of T2DM (ie, discovered at Screening) should be based on the 2013 American Diabetes Association (ADA) guidelines.

All T2DM subjects must have an HbA[1c] less than 10% at Screening. If subjects are being treated, or upon diagnosis need to be treated with antidiabetic agents, the T2DM treatment regimen must be stable for at least 3 months prior to randomization.

Exclusion Criteria

  1. Moderate or greater symptoms of congestive cardiac failure (New York Heart Association [NYHA] class III or IV)
  2. Known left ventricular (LV) ejection fraction less than 20%
  3. Moderate or greater symptoms of pulmonary hypertension (PH)
  4. Known severe valvular disease Moderate renal impairment, severe renal impairment, or end stage renal disease (ESRD) (calculated creatinine clearance less than 30 mL/min per the CKD-EPI equation based on ideal body weight)
  5. Severe hepatic impairment
  6. Use of other products intended for weight loss including prescription drugs, over-the-counter (OTC) drugs, and herbal preparations
  7. Use of more than one other serotonergic drug
  8. Use of drugs known to increase the risk for cardiac valvulopathy prior to Screening including, but not limited to: cyproheptadine, amoxapine, TCAs, mirtazapine, pergolide, ergotamine, methysergide, cabergoline
  9. History or evidence of clinically significant disease (e.g., malignancy, cardiac, respiratory, gastrointestinal, renal or psychiatric disease)
  10. Use of lorcaserin HCl prior to Screening or hypersensitivity to lorcaserin HCl or any of the excipients
  11. Planned bariatric surgery
  12. Females must not be breastfeeding or pregnant

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02019264


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Locations
United States, Alabama
Advanced Cardiovascular, LLC
Alexander City, Alabama, United States, 35010
North Alabama Research Center, LLC
Athens, Alabama, United States, 35611
UAB Medical Center
Birmingham, Alabama, United States, 35294
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Coastal Clinical Research, Inc.
Mobile, Alabama, United States, 36608
Mobile Heart Specialists, PC
Mobile, Alabama, United States, 36608
Clinical and Translational Research Center of Alabama
Tuscaloosa, Alabama, United States, 35406
United States, Alaska
Alaska Heart Institute
Anchorage, Alaska, United States, 99508
United States, Arizona
Connect Clinical Research Center, LCC
Chandler, Arizona, United States, 85224
Arrowhead Health Centers
Glendale, Arizona, United States, 85306
Phoenix Heart, PLLC
Glendale, Arizona, United States, 85306
Eclipse Clinical Research
Tucson, Arizona, United States, 85745
United States, Arkansas
NEA Baptist Clinic
Jonesboro, Arkansas, United States, 72401
Arkansas Cardiology Clinic
Little Rock, Arkansas, United States, 72205
Central Arkansas Veterans Healthcare System
Little Rock, Arkansas, United States, 72205
Preferred Research Partners
Little Rock, Arkansas, United States, 72211
United States, California
Clinical Research Alliance
Alhambra, California, United States, 91801
Central Cardiology
Bakersfield, California, United States, 93308
Cardiovascular Research Foundation of Southern Cal
Beverly Hills, California, United States, 90210
Capitol Interventional Cardiology
Carmichael, California, United States, 95608
San Diego Costal Endocrinology Group AMC
Chula Vista, California, United States, 91910 3813
John Muir Physician Network Clinical Research Cent
Concord, California, United States, 94520
Medical Group of Encino
Encino, California, United States, 91436
Marin Endocrine Care & Research, Inc.
Greenbrae, California, United States, 94904
California Heart Specialists
Huntington Beach, California, United States, 92648
Del Rosario Medical Clinic, Inc.
Huntington Park, California, United States, 90255
Diabetes and Endocrine Associates
La Mesa, California, United States, 91942
La Mesa Cardiac Center
La Mesa, California, United States, 91942
Alliance Research Centers
Laguna Hills, California, United States, 92653
Torrance Clinical Research Institute, Inc.
Lomita, California, United States, 90717
Long Beach Center for Clinical Research
Long Beach, California, United States, 90807
Metabolic Clinic and Research Center
Los Angeles, California, United States, 90033
Beverly Hills Cardiology
Los Angeles, California, United States, 90067
VA Greater Los Angeles Health Care System
Los Angeles, California, United States, 90073
Clinical Interventions Research Institute
Mission Viejo, California, United States, 92692
Brigid Freyne MD Inc
Murrieta, California, United States, 92563
Valley Clinical Trials Inc
Northridge, California, United States, 91325
Carr Cardiology
Oceanside, California, United States, 92056
Northern California Clinical Research Center
Redding, California, United States, 96001
Aoki Diabetes Research Institute
Sacramento, California, United States, 95816
Regional Cardiology Associates
Sacramento, California, United States, 95819
Sharp Rees-Stealy Medical Group, Inc.
San Diego, California, United States, 92101
University of California San Diego
San Diego, California, United States, 92103
Ritchken and First MD's
San Diego, California, United States, 92117
West Coast Research LLC
San Ramon, California, United States, 94582
Coastal Multi-Specialty Research
Santa Ana, California, United States, 92704
Santa Rosa Cardiology Medical Group Inc.
Santa Rosa, California, United States, 95405
Westlake Medical Research
Thousand Oaks, California, United States, 91360
Harbor - UCLA Medical Center
Torrance, California, United States, 90509
Ronald Chochinov, MD
Ventura, California, United States, 93003
Ventura Cardiology Consultants
Ventura, California, United States, 93003
Infosphere Clinical Research
West Hills, California, United States, 91307
United States, Colorado
Colorado Springs Health Partners PC
Colorado Springs, Colorado, United States, 80907
UCH-MHS Cardiac Research
Colorado Springs, Colorado, United States, 80909
Creekside Endocrine Associates PC
Denver, Colorado, United States, 80209
Horizons Clinical Research
Denver, Colorado, United States, 80220
New West Physicians, PC
Golden, Colorado, United States, 80401
South Denver Cardiology Associates, P.C.
Littleton, Colorado, United States, 80120
University of Colorado Health
Loveland, Colorado, United States, 80538
United States, Connecticut
Connecticut Clinical Research, LLC
Bridgeport, Connecticut, United States, 6606
Bridgeport Hospital
Bridgeport, Connecticut, United States, 6610
Clinical Research Works, Bristol
Bristol, Connecticut, United States, 06010-5103
Cardiology Associates of Fairfield County, Norwalk
Norwalk, Connecticut, United States, 06851
Cardiology Associates of Fairfield County, P.C.
Stamford, Connecticut, United States, 06905
Stamford Therapeutics Consortium
Stamford, Connecticut, United States, 6905
Connecticut Heart and Vascular Center
Trumbull, Connecticut, United States, 06611
Cardiology Associates of Fairfield County, P.C.
Trumbull, Connecticut, United States, 6611
Chase Medical Research, LLC
Waterbury, Connecticut, United States, 6708
United States, Delaware
Christiana Care Health Services
Newark, Delaware, United States, 19713
Red Clay Research
Newark, Delaware, United States, 19713
Alfieri Cardiology
Wilmington, Delaware, United States, 19803-3733
United States, Florida
Aventura Heart Center
Aventura, Florida, United States, 33180
Altus Research Inc.
Boynton Beach, Florida, United States, 33427
Zasa Clinical Research
Boynton Beach, Florida, United States, 33427
Meridien Research
Bradenton, Florida, United States, 34201
NOVA Southeastern University
Bradenton, Florida, United States, 34209
Bay Area Cardiology
Brandon, Florida, United States, 33511
Meridien Research, Brooksville
Brooksville, Florida, United States, 34609
Clearwater Cardiovascular and Interventional Cons.
Clearwater, Florida, United States, 33756
Clinical Research of South Florida
Coral Gables, Florida, United States, 33134
Holy Cross Medical Group
Coral Springs, Florida, United States, 33065
Cardiology Research Associates
Daytona Beach, Florida, United States, 32117
International Medical Research
Daytona Beach, Florida, United States, 32117
Asclepius Medical Research
Doral, Florida, United States, 33166
Fleming Island Center for Clinical Research
Fleming Island, Florida, United States, 32003
Infinity Clinical Research, LLC
Fort Lauderdale, Florida, United States, 33312
Integrative Research Associates, Inc.
Fort Lauderdale, Florida, United States, 33312
M & O Clinical Research, LLC
Fort Lauderdale, Florida, United States, 33316
Primary Care Associates
Fort Myers, Florida, United States, 33907
Florida Research Network, LLC
Gainesville, Florida, United States, 32605
George E. Platt, M.D.
Green Cove Springs, Florida, United States, 32043
Eastern Research, Inc.
Hialeah, Florida, United States, 33013
Larry K. Levinson, D.O., P.A.
Hollywood, Florida, United States, 33021
Research Physicians Network Alliance
Hollywood, Florida, United States, 33021
Pasco Cardiology Center
Hudson, Florida, United States, 34667
Nature Coast Clinical Research
Inverness, Florida, United States, 34452
University of Florida- Jacksonville
Jacksonville, Florida, United States, 32209
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States, 32216
Westside Center for Clinical Research
Jacksonville, Florida, United States, 32216
Meridien Research
Lakeland, Florida, United States, 33805
Watson Clinic LLP
Lakeland, Florida, United States, 33805
Pharmax Research Clinic, Inc
Miami, Florida, United States, 33126-2956
Life Spring Research Foundation
Miami, Florida, United States, 33134
United Clinical Research Corp.
Miami, Florida, United States, 33155
Cardiovascular Research Center of South Florida
Miami, Florida, United States, 33173
South Florida Research Group LLC
Miami, Florida, United States, 33176
South Florida Research Solutions
Miramar, Florida, United States, 33025
Southwest Florida Research
Naples, Florida, United States, 34102
Ocala Research Institute, Inc
Ocala, Florida, United States, 34471
Oviedo Medical Research
Oviedo, Florida, United States, 32765
Cardiology Partners Clinical Research Institute
Palm Beach Gardens, Florida, United States, 33410-4304
Palm Beach Gardens Research Center
Palm Beach Gardens, Florida, United States, 33410
Research Physicians Network Alliance, Pembrok
Pembroke Pines, Florida, United States, 33025
South Florida Research Solutions
Pembroke Pines, Florida, United States, 33028
Cardiology Consultants
Pensacola, Florida, United States, 32501 6335
Clinical Research of Central Florida
Plant City, Florida, United States, 33563
Columbia Primary Care, LLC d/b/a Heart and Health Institute
Plantation, Florida, United States, 33324
St Johns Center for Clinical Research
Ponte Vedra, Florida, United States, 32081
Charlotte Heart Group Research Center
Port Charlotte, Florida, United States, 33952
Progressive Medical Research
Port Orange, Florida, United States, 32127
Brevard Cardiovascular Research Associates Inc
Rockledge, Florida, United States, 32955
Clearwater Cardiovascular and Interventional Cons.
Safety Harbor, Florida, United States, 34695
Bayfront Health St. Petersburg, Research
Saint Petersburg, Florida, United States, 33701
Meridien Research - St. Petersburg
Saint Petersburg, Florida, United States, 33709
Professional Health Care of Pinellas, INC
Saint Petersburg, Florida, United States, 33713
Intercoastal Medical Group
Sarasota, Florida, United States, 34239
Springfield Medical Center
Springfield, Florida, United States, 32401
Advanced Clinical Research Group
Stuart, Florida, United States, 34996
Meridien Research - Tampa
Tampa, Florida, United States, 33606
Clinical Research of West Florida, inc.
Tampa, Florida, United States, 33609
Stedman Clinical Trials
Tampa, Florida, United States, 33613
Healthpoint Medical Group, Inc
Tampa, Florida, United States, 33614
Interventional Cardiac Consultants
Trinity, Florida, United States, 34655
Lovelace Scientific Research
Venice, Florida, United States, 34292
G&G Research, Inc
Vero Beach, Florida, United States, 32960-3296
Indian River Medical Center-Cardiology
Vero Beach, Florida, United States, 32960-3296
Cardiology Partners Clinical Research Institute
Wellington, Florida, United States, 33449
Cleveland Clinic Foundation
West Palm Beach, Florida, United States, 33401
Metabolic Research Institute
West Palm Beach, Florida, United States, 33401
Clinical Research of Central Florida
Winter Haven, Florida, United States, 33880
United States, Georgia
Atlanta Diabetes Associates, Endocrinology
Atlanta, Georgia, United States, 30318
Saint Joseph's Hospital of Atlanta
Atlanta, Georgia, United States, 30342
Rockdale Medical-Research Associates
Conyers, Georgia, United States, 30094
Atlanta Heart Specialists
Cumming, Georgia, United States, 30041
Urban Family Practice Associates/Clinical Research Advantage
Marietta, Georgia, United States, 30067
Endocrine Research Solutions, Inc.
Roswell, Georgia, United States, 30076
Herman Clinical Research LLC
Suwanee, Georgia, United States, 30024
Atlanta Heart Specialists
Tucker, Georgia, United States, 30084
United States, Illinois
Northwest Heart Clinical Research, LLC
Arlington Heights, Illinois, United States, 60005
Cedar-Crosse Research Center
Chicago, Illinois, United States, 60607
Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States, 60611
University of Chicago
Chicago, Illinois, United States, 60637
Consultants in Cardiovascular Medicine
Elmhurst, Illinois, United States, 60126
Clinical Investigation Specialists, Inc. in Gurnee
Gurnee, Illinois, United States, 60031
Advanced CardioVascular Consultants, SC
Rock Island, Illinois, United States, 61201
United States, Indiana
Community Clinical Research Center
Anderson, Indiana, United States, 46011
American Health Network of IN, LLC, Avon
Avon, Indiana, United States, 46123
Premier Healthcare, LLC
Bloomington, Indiana, United States, 47403 3239
Deaconess Clinic, Inc.
Evansville, Indiana, United States, 47713
Parkview Research Center
Fort Wayne, Indiana, United States, 46845
American Health Network of IN, LLC, Franklin
Franklin, Indiana, United States, 46131
American Health Network of IN, LLC, Greenfield
Greenfield, Indiana, United States, 46140
American Health Network - Thomas Moretto, MD
Indianapolis, Indiana, United States, 46254-5471
St. Vincent Medical Group Inc.
Indianapolis, Indiana, United States, 46290
Medical Consultants PC
Muncie, Indiana, United States, 47303
American Health Network of IN, LLC
Muncie, Indiana, United States, 47304
Cardiology Associates of Northwest Indiana, P.C
Munster, Indiana, United States, 46321
United States, Iowa
Clinical Research Advantage / Ridge Family Practic
Council Bluffs, Iowa, United States, 51503
The University of Iowa, College of Public Health
Iowa City, Iowa, United States, 52242
United States, Kansas
Professional Research Network of Kansas, LLC
Wichita, Kansas, United States, 67203
Heartland Research Assoc., LL
Wichita, Kansas, United States, 67207
United States, Kentucky
Norton Cardiovascular Associates
Louisville, Kentucky, United States, 40205 3338
Norton Heart Specialists
Louisville, Kentucky, United States, 40205-3338
L-MARC Research Center
Louisville, Kentucky, United States, 40213
Research Integrity LLC
Owensboro, Kentucky, United States, 42303
United States, Louisiana
Louisiana Heart Center
Covington, Louisiana, United States, 70433
United States, Maine
Central Maine Medical Center
Auburn, Maine, United States, 04210
Eastern Maine Medical Center Northeast Cardiology Associates
Bangor, Maine, United States, 04401
Acadia Clinical Research, LLC
Bangor, Maine, United States, 4401
Southern Maine Health Care/Maine Medical Center Research Ins
Biddeford, Maine, United States, 4005
InterMed, PA
Portland, Maine, United States, 4101
United States, Maryland
Medstar Cardiology Associates
Annapolis, Maryland, United States, 21401
Chesapeake Cardiovascular Associates, GBMC
Baltimore, Maryland, United States, 21204
Clinical Research, Inc
Baltimore, Maryland, United States, 21204
Medstar Union Memorial Heart Specialists
Baltimore, Maryland, United States, 21218
Medstar Union Memorial Hospital
Baltimore, Maryland, United States, 21218
Spectrum Clinical Research
Baltimore, Maryland, United States, 21229
Overlea Personal Physicians
Baltimore, Maryland, United States, 21236
Shahid Saeed MD, PC
Baltimore, Maryland, United States, 21237
Suburban Hospital
Bethesda, Maryland, United States, 20814
Maryland Heart Associates, LLC
Glen Burnie, Maryland, United States, 21061
Klein & Associates, MD, PA
Hagerstown, Maryland, United States, 21740
MedStar Health Research Institute
Hyattsville, Maryland, United States, 20782
Lutherville Personal Physicians
Lutherville, Maryland, United States, 21093
MD Medical Research
Oxon Hill, Maryland, United States, 20745
Endocrine & Metabolic Consultants
Rockville, Maryland, United States, 20852
Lutherville Personal Physicians
Towson, Maryland, United States, 21204
Overlea Personal Physicians
Towson, Maryland, United States, 21204
United States, Massachusetts
Tufts Medical Center
Boston, Massachusetts, United States, 02111
MGH Weight Center
Boston, Massachusetts, United States, 02114
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
New England Center for Clinical Research, IMCA
Fall River, Massachusetts, United States, 2720
Pentucket Medical Associates
Haverhill, Massachusetts, United States, 1830
ActivMed Practices
Methuen, Massachusetts, United States, 01844
Partners Community Physicians Organization
Natick, Massachusetts, United States, 01760
Partners Community Physicians Organization
Needham, Massachusetts, United States, 02494
Baystate Medical Center
Springfield, Massachusetts, United States, 01199
United States, Michigan
Endeavor Medical Research PLC
Alpena, Michigan, United States, 49707
Cadillac Clinical Research, LLC
Cadillac, Michigan, United States, 49601
Alzohaili Medical Consultants
Dearborn, Michigan, United States, 48124
Westside Family Medical Center, PC
Kalamazoo, Michigan, United States, 49009
Cardiology Consultants of East Michigan
Lapeer, Michigan, United States, 48446
Marquette General Heart and Vascular Institute
Marquette, Michigan, United States, 49855
MidMichigan Medical Center
Midland, Michigan, United States, 48670
Nisus Research at McLaren Northern Michigan Hospital
Petoskey, Michigan, United States, 49770
Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, United States, 48341-2985
Remedica LLC
Rochester, Michigan, United States, 48307
Michigan CardioVascular Institute
Saginaw, Michigan, United States, 48601 1423
American Center for Clinical Trials
Southfield, Michigan, United States, 48034
Medical Research Associates, Inc.
Traverse City, Michigan, United States, 49684-2386
Waterford Medical Associates
Waterford, Michigan, United States, 48328
Michigan Heart
Ypsilanti, Michigan, United States, 48197
United States, Minnesota
Minneapolis Heart Institute Foundation
Baxter, Minnesota, United States, 56425
Essentia Institute of Rural Health
Duluth, Minnesota, United States, 55805
MNCOME Clinic
Eagan, Minnesota, United States, 55123
Radiant Research, Inc.
Edina, Minnesota, United States, 55435
Minneapolis Heart Institute
Minneapolis, Minnesota, United States, 55407
CentraCare Heart and Vascular Center
Saint Cloud, Minnesota, United States, 56303
Regions Hospital
Saint Paul, Minnesota, United States, 55101
United States, Mississippi
Coast Cardiovascular Consultants PLLC
Gulfport, Mississippi, United States, 39501
Cardiology Associates Research, LLC
Tupelo, Mississippi, United States, 38801
United States, Missouri
Diabetes & Endocrinology Specialists, Inc.
Chesterfield, Missouri, United States, 63017
Washington University
Saint Louis, Missouri, United States, 63110
BodyAesthetic Research Center
Washington, Missouri, United States, 63090
United States, Montana
Billings Clinic Research Center
Billings, Montana, United States, 59101
Montana Health Research Institute, Inc.
Billings, Montana, United States, 59102
Glacier View Cardiology PC
Kalispell, Montana, United States, 59901
United States, Nebraska
Internal Medical Associates of Grand Island, PC
Grand Island, Nebraska, United States, 68803
United States, Nevada
Clinical Research Advantage / Rita Chuang, M.D.
Henderson, Nevada, United States, 89052
Clinical Research Advantage, Inc.
Las Vegas, Nevada, United States, 89117
Clinical Research of South Nevada
Las Vegas, Nevada, United States, 89121
United States, New Jersey
Medicor Cardiology, PA
Bridgewater, New Jersey, United States, 08807-3060
Advanced Heart Care
Bridgewater, New Jersey, United States, 08807
UmiMed Center LLC
East Brunswick, New Jersey, United States, 8816
Raritan Bay Cardiology
Edison, New Jersey, United States, 08837
Cardiovascular Associates of the Delaware Valley
Elmer, New Jersey, United States, 08318-1715
Advocare Heights Primary Care
Haddon Heights, New Jersey, United States, 08035
Cardiovascular Associates of the Delaware Valley P
Haddon Heights, New Jersey, United States, 8035
NJ Heart
Linden, New Jersey, United States, 07036
Rutgers New Jersey Medical School
Mine Hill, New Jersey, United States, 07103
Cardiovascular Associates Delaware Valley Sewell
Sewell, New Jersey, United States, 08080-1715
Cardio Metabolic Institute
Somerset, New Jersey, United States, 8873
United States, New Mexico
New Mexico Heart Institute, PA
Albuquerque, New Mexico, United States, 87102
United States, New York
Albany College of Medicine, Division of Endocrinology
Albany, New York, United States, 12206
Capital Cardiology Associates
Albany, New York, United States, 12211
United Medical Associates, PC
Binghamton, New York, United States, 13901
James J. Peters VA Medical Center, Bronx, NY
Bronx, New York, United States, 10468
Buffalo Heart Group
Buffalo, New York, United States, 14215
NYU Hudson Valley Cardiology
Cortlandt Manor, New York, United States, 10567
Regional Clinical Research, Inc.
Endwell, New York, United States, 13760
Long Island Gastrointestinal Research Group LLP
Great Neck, New York, United States, 11023
Long Island Heart Associates
Mineola, New York, United States, 11501
North Shore Diabetes and Endocrine Associates
New Hyde Park, New York, United States, 11042
Weill Cornell Medical College
New York, New York, United States, 10065
DiGiovanna Institute for Medical Education
North Massapequa, New York, United States, 11758
Hudson Valley Heart Center
Poughkeepsie, New York, United States, 12601
Rochester Clinical Research, Inc.
Rochester, New York, United States, 14609
Northwell Health Physician Partners Cardiology
Southampton, New York, United States, 11968
SUNY Upstate Medical University
Syracuse, New York, United States, 13210
Capital Cardiology Associates
Troy, New York, United States, 12180
Great Lakes Medical Research
Westfield, New York, United States, 14787
United States, North Carolina
Kernodle Clinic
Burlington, North Carolina, United States, 27215
Clinical Trials of America Inc.
Cary, North Carolina, United States, 27518
Metrolina Internal Medicine
Charlotte, North Carolina, United States, 28204
PMG Research of Charlotte, LLC
Charlotte, North Carolina, United States, 28209
Duke University Medical Centre, Obesity Clinical T
Durham, North Carolina, United States, 27710
Bland Clinic, PA
Greensboro, North Carolina, United States, 27401
Clinical Trials of America Inc. Hickory
Hickory, North Carolina, United States, 28601
Clinical Trials of America, Inc.
Hickory, North Carolina, United States, 28601
Peters Medical Research
High Point, North Carolina, United States, 27262
Clinical Trials of America, Inc.
Lenoir, North Carolina, United States, 28645
Diabetes & Endocrinology Consultants
Morehead City, North Carolina, United States, 28557
Burke Primary Care
Morganton, North Carolina, United States, 28655
Pinehurst Medical Clinic, Inc.
Pinehurst, North Carolina, United States, 28374-8798
Wake Research Associates, LLC
Raleigh, North Carolina, United States, 27612
PMG Research of Rocky Mount
Rocky Mount, North Carolina, United States, 27804
PMG Research of Salisbury
Salisbury, North Carolina, United States, 28144
Sanford Cardiology
Sanford, North Carolina, United States, 27330
Piedmont Healthcare
Statesville, North Carolina, United States, 28625
PMG Research of Wilmington
Wilmington, North Carolina, United States, 28401
PMG Research of Winston-Salem, LLC
Winston-Salem, North Carolina, United States, 27103
United States, North Dakota
Lillestol Research LLC
Fargo, North Dakota, United States, 58103
United States, Ohio
Center for Thyroid Diseases and Endocrinology
Beachwood, Ohio, United States, 44122
Aultman Hospital
Canton, Ohio, United States, 44710
The Lindner Research Center
Cincinnati, Ohio, United States, 45219
Sentral Clinical Research
Cincinnati, Ohio, United States, 45236
Delaware Research Group, LLC
Delaware, Ohio, United States, 43015
North Ohio Research Ltd.
Elyria, Ohio, United States, 44035
Awasty Research Network, LLC
Marion, Ohio, United States, 43302
Community Health Care
Massillon, Ohio, United States, 44646
North Ohio Research Ltd., Sandusky
Sandusky, Ohio, United States, 44870
Apex Medical Research Inc.
Springfield, Ohio, United States, 45505
Jobst Vascular Institute at ProMedica Toledo Hospi
Toledo, Ohio, United States, 43606
Genesis Health Care System
Zanesville, Ohio, United States, 43701
United States, Oklahoma
Integris Cardiovascular Physicians LLC
Oklahoma City, Oklahoma, United States, 73112
Memorial Clinical Research
Oklahoma City, Oklahoma, United States, 73120
South Oklahoma Heart Research, LLC
Oklahoma City, Oklahoma, United States, 73135
Oklahoma Heart Institute
Tulsa, Oklahoma, United States, 74104
Vital Prospects Clinical Research Institute PC
Tulsa, Oklahoma, United States, 74136 7028
United States, Pennsylvania
Blair Medical Associates
Altoona, Pennsylvania, United States, 16602
Clinical Research Associates of Central PA, LLC
Altoona, Pennsylvania, United States, 16602
Heritage Valley Medical Group, Inc
Beaver, Pennsylvania, United States, 15009
Capital Area Research, LLC
Camp Hill, Pennsylvania, United States, 17011
Geisinger Health Clinic
Danville, Pennsylvania, United States, 17822
Geisinger Health System
Danville, Pennsylvania, United States, 17822
Central Bucks Cardiology
Doylestown, Pennsylvania, United States, 18901
Doylestown Cardiology Specialists-VIAA
Doylestown, Pennsylvania, United States, 18901
Doylestown Health Cardiology a Division of Doylestown Health
Doylestown, Pennsylvania, United States, 18901
Altoona Center for Clinical Research
Duncansville, Pennsylvania, United States, 16635
Liberty Family Practice
Erie, Pennsylvania, United States, 16508
Endocrine Clinical Research, LLC
Feasterville-Trevose, Pennsylvania, United States, 19053
Endocrine Clinical Research, LLC
Feasterville-Trevose, Pennsylvania, United States
Endocrine Clinical Research LLC
Feasterville, Pennsylvania, United States, 19053
East Texas Cardiology, PA
Houston, Pennsylvania, United States, 77002
Joseph Lamantia, DO
Indiana, Pennsylvania, United States, 15701
The Clinical Trial Center, LLC
Jenkintown, Pennsylvania, United States, 19046
Lycoming Internal Medicine, Inc.
Jersey Shore, Pennsylvania, United States, 17740
Berkley Hills Clinicals
Johnstown, Pennsylvania, United States, 15905-3443
Ilumina Clinical Associates, Johnstown
Johnstown, Pennsylvania, United States, 15905
Joseph Lamantia, DO
Johnstown, Pennsylvania, United States, 15905
Comprehensive Cardiology Consultants
Langhorne, Pennsylvania, United States, 19047
Detweiler Family Medicine and Associates PC
Lansdale, Pennsylvania, United States, 19446
Green & Seidner Family Practice Associates
Lansdale, Pennsylvania, United States, 19446
Capital Area Research LLC
Newport, Pennsylvania, United States, 17074
Endocrine Metabolic Associates
Philadelphia, Pennsylvania, United States, 19114
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Pottstown Medical Specialists, Inc. (PMSI)
Pottstown, Pennsylvania, United States, 19464
Guthrie Medical Group, P.C
Sayre, Pennsylvania, United States, 18840
Geisinger Clinic
Scranton, Pennsylvania, United States, 18508
Tyrone Medical Associates
Tyrone, Pennsylvania, United States, 16686
United States, Rhode Island
Partners in Clinical Research
Cumberland, Rhode Island, United States, 2864
United States, South Carolina
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Radiant Research, Inc.
Greer, South Carolina, United States, 29650
Synexus USA
Greer, South Carolina, United States, 29650
Mountain View Clinical Research
Greer, South Carolina, United States, 29651
Palmetto Research Center, LLC
Spartanburg, South Carolina, United States, 29302
United States, South Dakota
Brown Clinic, PLLP
Watertown, South Dakota, United States, 57201
United States, Tennessee
PMG Research of Bristol, LLC
Bristol, Tennessee, United States, 37620
Chattanooga Research and Medicine (CHARM)
Chattanooga, Tennessee, United States, 37404
WR-ClinSearch, LLC
Chattanooga, Tennessee, United States, 37421
Wellmont CVA Heart Institute
Greeneville, Tennessee, United States, 37745-5810
Kore Cardiovascular Research
Jackson, Tennessee, United States, 38305
Research Associates of Jackson
Jackson, Tennessee, United States, 38305
The Jackson Clinic, PA
Jackson, Tennessee, United States, 38305
Wellmont CVA Heart Institute
Johnson City, Tennessee, United States, 37604
Holston Medical Group
Kingsport, Tennessee, United States, 37660
Wellmont CVA Heart Institute
Kingsport, Tennessee, United States, 37660
The Endocrine Clinic
Memphis, Tennessee, United States, 38119
Cardiology Wellness Center
Nashville, Tennessee, United States, 37203
United States, Texas
Amarillo Center for Clinical Research Ltd
Amarillo, Texas, United States, 79124
Central Texas Clinical Research, LLC
Austin, Texas, United States, 78705
Texas Diabetes & Endocrinology
Austin, Texas, United States, 78731
Texas Health Physicians Group
Carrollton, Texas, United States, 75007
Adriana Pop-Moody MD Clinic, PA
Corpus Christi, Texas, United States, 78404
Baylor Research Institute
Dallas, Texas, United States, 75024
Texas Health Physicians Group
Dallas, Texas, United States, 75218
Texas Health Physicians Group, Dallas
Dallas, Texas, United States, 75220
Dallas Diabetes and Endocrine Center
Dallas, Texas, United States, 75230
Research Institute of Dallas
Dallas, Texas, United States, 75231
Galenos Research
Dallas, Texas, United States, 75251
Odilon Alvarado, M.D.
Fort Worth, Texas, United States, 76104
Texas Health Physicians Group Fort Worth
Fort Worth, Texas, United States, 76107
Tand R Clinic, PA
Fort Worth, Texas, United States, 76117
San Gabriel Clinical Research, LLC
Georgetown, Texas, United States, 78626
Angiocardiac Care of Texas PA
Houston, Texas, United States, 77025 5253
Baylor College of Medicine
Houston, Texas, United States, 77030
Heart Care Center
Houston, Texas, United States, 77070
Oxford Clinical Research, LLC
Houston, Texas, United States, 77074
West Houston Area Clinical Trial Consultants, LLC
Houston, Texas, United States, 77094
Endocrine and Psychiatry Center
Houston, Texas, United States, 77095
Texas Health Physicians Group
Irving, Texas, United States, 75039
Texas Cardiology Associates of Houston
Kingwood, Texas, United States, 77339
Jalil Aziz Khan M.D., P.A.
Lewisville, Texas, United States, 75067
DCOL Center for Clinical Research
Longview, Texas, United States, 75605
Midland Clinical Research Center
Midland, Texas, United States, 79707
Permian Research Foundation
Odessa, Texas, United States, 79761
Medical Clinic of North Texas
Plano, Texas, United States, 75023
Clinical Investigations of Texas, LLC
Plano, Texas, United States, 75075
Texas Diabetes
Round Rock, Texas, United States, 78681
Physician PrimeCare Research Institute, PLLC
San Antonio, Texas, United States, 78228
Cardiology Clinic of San Antonio
San Antonio, Texas, United States, 78229
Radiant Research San Antonio
San Antonio, Texas, United States, 78229
STAR Clinical Trials, LLC
San Antonio, Texas, United States, 78229
Martin Diagnostic Clinic
Tomball, Texas, United States, 77375
Cardiovascular Associates of East Texas
Tyler, Texas, United States, 75701
Bay Area Total Health Medical Group
Webster, Texas, United States, 77598
South Texas Medical Clinic
Wharton, Texas, United States, 77488
United States, Utah
Advanced Research Institute
Ogden, Utah, United States, 84405
Jean Brown Research
Salt Lake City, Utah, United States, 84124
United States, Virginia
Alexandria Clinical Research, LLC
Alexandria, Virginia, United States, 22304
Washington Center for Weight Management and Resear
Arlington, Virginia, United States, 22201
Burke Internal Medicine and Research
Burke, Virginia, United States, 22015
Cardiology Consultants of Danville, Inc.
Danville, Virginia, United States, 24541
Danville Internal Medicine, Inc
Danville, Virginia, United States, 24541
Virginia Heart
Falls Church, Virginia, United States, 22042-1262
Seven Corners Medical Research Center
Falls Church, Virginia, United States, 22044
Carient Heart and Vascular
Manassas, Virginia, United States, 20109
INOVA Health Care Services
Manassas, Virginia, United States, 20109
Burke Internal Medicine and Research
Manassas, Virginia, United States, 20110
Manassas Clinical Research Center
Manassas, Virginia, United States, 20110
Health Research of Hampton Roads - Norfolk, Inc.
Norfolk, Virginia, United States, 23502
Internal Medicine Kidney and Hypertension Center
Norfolk, Virginia, United States, 23502
Clinical Research Associates of Tidewater
Norfolk, Virginia, United States, 23507
Clinical Research Partners
Richmond, Virginia, United States, 23220
Virginia Commonwealth University
Richmond, Virginia, United States, 23220
Virginia Cardiovascular Specialists
Richmond, Virginia, United States, 23229
National Clinical Research-Richmond, Inc
Richmond, Virginia, United States, 23294
Selma Medical Associates
Winchester, Virginia, United States, 22601
United States, Washington
Larry D. Stonesifer, MD, Inc PS
Federal Way, Washington, United States, 98003
Seattle Women's
Seattle, Washington, United States, 98105
Rowan Research Inc.
Spokane, Washington, United States, 99218
MultiCare Research Institute
Tacoma, Washington, United States, 98405
Universal Research Group
Tacoma, Washington, United States, 98405
Wenatchee Valley Hospital & Clinics
Wenatchee, Washington, United States, 98801
United States, Wisconsin
Cardiology Associates of Bellin Health
Green Bay, Wisconsin, United States, 54301
Prevea Clinic, Inc
Green Bay, Wisconsin, United States, 54303
Clinical Investigation Specialists, Inc.
Kenosha, Wisconsin, United States, 53142
Meriter hospital Inc., DBA: UnityPoint Health-Meriter Heart
Madison, Wisconsin, United States, 53713
Gemini Scientific, LLC
Madison, Wisconsin, United States, 53719
Marshfield Clinic
Marshfield, Wisconsin, United States, 54449
Zablocki VAMC
Milwaukee, Wisconsin, United States, 53295
Aspirus Research Institute
Wausau, Wisconsin, United States, 54401
Australia, Australian Capital Territory
Bruce, Australian Capital Territory, Australia, 2617
Australia, New South Wales
Levels 4-6 Medical Foundation Building
Camperdown, New South Wales, Australia, 2050
Coffs Harbour Health Campus
Coffs Harbour, New South Wales, Australia, 2450
Gosford Hospital, Cardiology Clinical Trials
Gosford, New South Wales, Australia, NSW2250
Department of Cardiology
Kingswood, New South Wales, Australia, 2747
Liverpool Hospital
Liverpool, New South Wales, Australia, 2170
Illawarra Shoalhaven Local Health District, Clinical Trial and Research Unit
Wollongong, New South Wales, Australia, 2500
Wollongong Hospital
Wollongong, New South Wales, Australia, 2500
Australia, Queensland
Wesley Private Hospital & Greenslopes Private Hospital
Brisbane, Queensland, Australia, 4064
Princess Alexandra Hospital, Cardiology Research Department
Brisbane, Queensland, Australia, 4102
Core Research Group
Brisbane, Queensland, Australia
Royal Brisbane and Women's Hospital, Endocrinology Department
Herston, Queensland, Australia, 4029
HeartCare Partners Clinical Research Unit
Milton, Queensland, Australia, 4064
AusTrials Pty Ltd
Sherwood, Queensland, Australia, QLD 4075
Gold Coast Hospital, Cardiovascular Research Centre
Southport, Queensland, Australia, 4215
Australia, South Australia
New Royal Adelaide Hospital, Cardiology Department
Adelaide, South Australia, Australia, 5000
Adelaide Medical Research
Ashford, South Australia, Australia, 5035
Lyell McEwin Hospital, Department of Cardiology
Elizabeth Vale, South Australia, Australia, 5112
Heart and Vascular Institute
Fullarton, South Australia, Australia, SA 5063
The Queen Elizabeth Hospital, Cardiology Department Cardiology Department 3D
Woodville South, South Australia, Australia, SA 5011
Australia, Victoria
Ballarat Health Services
Ballarat, Victoria, Australia, 3353
First Floor, Masada Private Hospital
East Saint Kilda, Victoria, Australia, 3183
Cardiovascular Clinical Trials Unit Cardiology Outpaitents
Epping, Victoria, Australia, 3076
Geelong Cardiology Research Unit, Barwon Health
Geelong, Victoria, Australia, 3220
Austin Health - Heidelberg Repatriation Hospital, Department of Medicine, Boronia Centre
Heidelberg Heights, Victoria, Australia, 3081
Epworth HealthCare, Clinical Trials and Research Centre
Richmond, Victoria, Australia, 3121
Avenue Cardiovascular Centre
Saint Kilda East, Victoria, Australia
Australia, Western Australia
Joondalup Cardiovascular Trials Foundation Inc
Joondalup, Western Australia, Australia, 6027
Fiona Stanley Hospital, Cardiology Research Department,CDO11
Murdoch, Western Australia, Australia, 6150
Australia
South Australian Medical Research Inst, Centre for Clinical Research
Adelaide, Australia, 5000
Cardiology Clinical Research Centre
Chermside, Australia, 4032
Bahamas
The Partners Clinical Research Centre
Nassau, Bahamas
Canada, Alberta
LMC Clinical Research Inc. (Calgary)
Calgary, Alberta, Canada, T2H 2G4
Canada, British Columbia
The University of British Columbia
Vancouver, British Columbia, Canada, V5Z 1M9
Gordon and Leslie Diamond Health Care Centre
Vancouver, British Columbia, Canada
Canada, Nova Scotia
Nova Scotia Health Authority /QEII Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H 3A7
Canada, Ontario
LMC Diabetes & Endocrinology - Brampton
Brampton, Ontario, Canada, L6S0C9
McMaster University
Brampton, Ontario, Canada, L6Z 4N5
Brampton, Ontario, Canada, L6Z 4N5
JBN Medical Diagnostic Services Inc.
Burlington, Ontario, Canada, L7M 4Y1
Aviva Clinical Trial Group In.
Burlington, Ontario, Canada, L7R 1E2
Cambridge Cardiac Care Centre
Cambridge, Ontario, Canada, N1R 6V6
Joanne F. Liutkus Medicine Professional Corp.
Cambridge, Ontario, Canada, N1R 7L6
Saul Vizel Professional Medicine Corporation, Vizel Cardiac Research
Cambridge, Ontario, Canada, N1R 7R1
LMC Diabetes & Endocrinology (Etobicoke)
Etobicoke, Ontario, Canada, M9R4E1
Wharton Medical Clinic Clinical Trials Group Inc.
Hamilton, Ontario, Canada, L8L 5G8
Saint Josephs Health Care London
London, Ontario, Canada, N6A 5A5
LMC Diabetes & Endocrinoly
Markham, Ontario, Canada, L6B0P9
New Market Cardiology Research Group
Newmarket, Ontario, Canada, L3Y 8C3
LMC Diabetes & Endocrinology (Oakville)
Oakville, Ontario, Canada, L6H3P1
Dr. Michael Heffernan
Oakville, Ontario, Canada, L6K 3W7
Oshawa, Ontario, Canada, L1G 7W4
Dr. Cha
Oshawa, Ontario, Canada, L1J 2K1
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, Canada, K9J 0B2
Dr. Dinkar Shukla Professional Medicine Corporation
Sudbury, Ontario, Canada, P3E 2N8
Dr Roger Labonte Professional Medicine Corp
Sudbury, Ontario, Canada, P3E3B8
LMC Diabetes & Endocrinology (Thornhill)
Thornhill, Ontario, Canada, L4J8L7
Thunder Bay, Ontario, Canada, P7B 6V4
JJ DIG Research Ltd.
Toronto, Ontario, Canada, M3J 1N2
Keele Medical Place
Toronto, Ontario, Canada, M3M 3E5
LMC Clinical Research Inc. (Bayview)
Toronto, Ontario, Canada, M4G 3E8
St Michael's Hospital Health Centre
Toronto, Ontario, Canada, M5C 2T2
Toronto General Hospital, Dept of Med
Toronto, Ontario, Canada, M5C 2T2
Canada, Quebec
ViaCar Recherche Clinique
Brossard, Quebec, Canada, J4X 1S4
Q&T Research Outaouais Inc.
Gatineau, Quebec, Canada, J8Y 6S8
ViaCar Recherche Clinique Inc.
Greenfield Park, Quebec, Canada, J4V 2G8
Cardiology
Laval, Quebec, Canada, H7M 3L9
Laval, Quebec, Canada, H7T 2P5
Manna Research Inc
Levis, Quebec, Canada
Clinique Sante Cardio MC
Montreal, Quebec, Canada, H1T 3Y7
Universitaire de Cardiologie et de Pneumologie de Quebec
Quebec City, Quebec, Canada, G1V 4G5
Centre hospitalier régional de Lanaudière
Saint-Charles-Borromee, Quebec, Canada, J6E 6J2
Recherche Clinique London
Sherbrooke, Quebec, Canada, J1J 2E3
CardioVasc HR, Inc.
St Jean sur Richelieu, Quebec, Canada, J3A1C3
St-Georges Beauce, Quebec, Canada, G5Y 4T8
ViaCar Recherche Clinique Inc.
St-Lambert, Quebec, Canada, J4P 2H4
St-Romuald, Quebec, Canada, QC G6W 5M6
LMC Clinical Research Inc. (Montreal)
Ville Saint-Laurent, Quebec, Canada, H4T 1Z9
Canada, WA
Seattle, WA, Canada, 98101
Canada
Ville Saint-Laurent
Québec, Canada
Chile
Biomedica Research Group
Providencia, Santiago, Chile, 7500710
Sociedad Medica Cardiologica El Llano
San Miguel, Santiago, Chile, 8910259
Hospital Regional Concepcion
Concepcion, Chile
Servicios Medicos Godoy Ltda.
Santiago, Chile, 7500701
Cardiocob
Santiago, Chile, 8320000
Ccbr Cecim
Santiago, Chile
CECMI Ltda.
Temuco, Chile
Centro Investigacion Clinica del Sur
Temuco, Chile
Mexico
ICLE
Guadalajara, Jalisco, Mexico
Private Medical Practice
Guadalajara, Jalisco, Mexico
Cardiolink ClinTrials S.C.
Monterrey, Nuevo Leon, Mexico
Centro de Estudios Clinicos y Especialidades Medicas S.C.
Monterrey, Nuevo Leon, Mexico
IMED Clin Trials
Monterrey, Nuevo Leon, Mexico
Hospital de Angeles Xalapa
Xalapa, Veracruz, Mexico
Fundacion Cardiovascular de Aguascalientes
Aguascalientes, Mexico
Hospital Cardiologica Aguascalientes
Aguascalientes, Mexico
Mentrials S.A.de C.V.
Distrito Federal, Mexico
New Zealand
North Shore Hospital-Cardiology Research
Milford, Auckland, New Zealand, 622
Centre for Clinical Research & effective practice (CCREP)
Otahuhu, Auckland, New Zealand, 2025
Middlemore Hospital
Papatoetoe, Auckland, New Zealand
North Shore Hospital - Diabetes Clinic
Takapuna, Auckland, New Zealand, 740
Christchurch Hospital, Lipids
Christchurch, Canterbury, New Zealand, 8011
Christchurch Hospital, Cardiology Research
Christchurch, Canterbury, New Zealand, 8811
Dunedin Hospital
Dunedin, Otago, New Zealand, 9016
Taranaki Base Hospital
New Plymouth, Taranaki, New Zealand, 4310
Hutt Hospital, Cardiology Dept
Lower Hutt, Wellington, New Zealand, 5010
Newtown, Wellington, New Zealand, 6021
Auckland City Hospital
Auckland, New Zealand, 1142
Hawkes Bay Regional Hospital
Hastings, New Zealand, 4120
Nelson Hospital, Cardiology Department
Nelson, New Zealand, 7010
CCU Dept
Nelson, New Zealand
Endocrinology and Diabetology
Palmerston North, New Zealand, 4442
Lakeland Clinical Trials, Rotorua
Rotorua, New Zealand, 3010
Tauranga Hospital
Tauranga, New Zealand, 3110
Bay of Plenty Clinical School Charitable Trust
Tauranga, New Zealand, 3112
Poland
NZOZ "Eskulap"
Biala Rawska, Poland, 96-230
Podlaski Osrodek Kardiologii Janusz Korecki
Białystok, Poland, 15-875
Centrum Medyczne KERmed
Bydgoszcz, Poland, 85-231
10 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ
Bydgoszcz, Poland, 85-681
Nzoz "Mada-Med"
Chorzów, Poland, 41-500
DIABET Centrum Medyczne s. c.
Chrzanów, Poland, 32-500
ISPL w Dziedzinie Kardiologii lek.med. Krzysztof Cymerman
Gdynia, Poland, 81-157
NZOZ SCBK ProCordis
Gdynia, Poland, 81-423
Gabinet Kardiologiczno-Internistyczny
Gdynia, Poland, 81-472
Praktyka Lekarska dr n. med. Marek Bronisz
Inowroclaw, Poland, 88-100
Piotr Mader Diabetic Clinic NZOZ PD-I
Kamieniec Ząbkowicki, Poland, 57-230
NZOZ Eskulap SC
Koluszki, Poland, 95-040
Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
Kraków, Poland, 30-082
Medyczne Centrum Diabetologiczno Endokrynologiczno
Kraków, Poland, 31-261
Kraków, Poland, 31-501
LANDA' Specjalistyczne Gabinety Lekarskie
Kraków, Poland, 31-881
Indywidualna Specjalistyczna Praktyka Lekarska
Krzekowo-Bezrzecze, Poland
Nzoz Cardiamed
Legnica, Poland, 59-220
"CenterMed Lublin" Sp. z o.o.
Lublin, Poland, 20-044
Indywidualna Praktyka Lekarska
Mrągowo, Poland, 11-700
Zechowicz MEDEUSZ-PLUS
Olsztyn, Poland, 10-010
Piotrków Trybunalski, Poland, 97-300
Praktyka Lekarska Ewa Krzyzagorska
Poznań, Poland, 61-655
NZOZ NEURO-KARD "Ilkowski i Partnerzy"
Poznań, Poland, 61-853
Specjalistyczna Przychodnia Lekarska MEDIKARD (SPL Medikard)
Płock, Poland, 09-402
Specjalistyczny Gabinet Lekarski
Tarnów, Poland, 33-100
Lecznice Citomed Sp. z o.o.
Toruń, Poland, 87-100
Praktyka Lekarska Pawlowicz Lidia
Toruń, Poland, 87-100
Warsaw, Poland, 00-838
Centrum Medyczne AMED
Warszawa, Poland, 01-518
Centrum Badawcze Wspolczesnej Terapii
Warszawa, Poland, 02-679
SNZOZ Fundacji PROCLINICA
Warszawa, Poland, 03-973
Centrum Zdrowia Wierzchoslawice
Wierzchosławice, Poland, 33-122
Regionalna Poradnia Diabetologiczna
Wroclaw, Poland, 50-127
Specjalistyczne Gabinety Lekarskie "Medicor PLUS"
Włocławek, Poland, 87-800
NZOZ ALL-MED Centrum Medyczne
Łódź, Poland, 91-347
SP ZOZ w Lecznej
Łęczna, Poland, 21-010
Puerto Rico
Dr. Elena Gonzalez M.D.
Cidra, Puerto Rico, 00739
Instituto Medico del Dolor y Medicinas Complementarias Inc.
San Juan, Puerto Rico, 918
Sponsors and Collaborators
Eisai Inc.
Thrombolysis In Myocardial Infarction (TIMI) Academic Research Organization

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Eisai Inc.
ClinicalTrials.gov Identifier: NCT02019264     History of Changes
Other Study ID Numbers: APD356-G000-401
2013-000324-34 ( EudraCT Number )
First Posted: December 24, 2013    Key Record Dates
Last Update Posted: September 6, 2018
Last Verified: November 2017

Studies a U.S. FDA-regulated Drug Product: Yes

Keywords provided by Eisai Inc.:
Diabetes
Cardiovascular Disease
Multiple Cardiovascular Risk Factors
Obesity
Overweight
MACE
Conversion to Diabetes

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Overweight
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Body Weight
Signs and Symptoms