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Trial record 40 of 250 for:    test AND provocation

Bronchial Hyperreactivity During Histamine Passive Exposure

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ClinicalTrials.gov Identifier: NCT01937494
Recruitment Status : Completed
First Posted : September 9, 2013
Last Update Posted : February 23, 2015
Sponsor:
Information provided by (Responsible Party):
Marie Bruyneel, Centre Hospitalier Universitaire Saint Pierre

Brief Summary:
Bronchial hyperresponsiveness consists in excessive response to bronchial stimuli.Bronchial challenge test is used to confirm/exclude asthma (metacholine or histamine).Protection are used to avoid passive exposure of the technicians performing the test, despite the absence of evidence that they could develop a bronchoconstriction even if they suffer from BHR.The purpose of the study is to determine if patients with a high level of bronchial hyperreactivity and exposed passively to histamine during a bronchial challenge, are developing a bronchoconstriction, when placed in the same conditions that the technicians performing these tests.

Condition or disease Intervention/treatment Phase
Asthma Bronchial Hyperresponsiveness Drug: histamine-benzylic alcohol (magistral preparation) Not Applicable

Detailed Description:

Bronchial hyperresponsiveness (BHR) consists in excessive response to bronchial stimuli.Bronchial challenge test is used to confirm/exclude asthma.BHR is also present in other diseases such as allergic rhinitis, Chronic Obstructive pulmonary disease,heart failure..

Thes test is performed with metacholine or histamine with spirometric documented response to incremental doses.Protection are used to avoid passive exposure of the technicians performing the test, despite the absence of evidence that they could develop a bronchoconstriction if they suffer from BHR.

The purpose of the study is to determine if patients, newly diagnosed with a high level of bronchial hyperreactivity and exposed passively to histamine during a bronchial challenge, are reacting to histamine when placed in the same conditions that the technicians performing these tests.


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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 13 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Are Technicians Showing Bronchial Hyperreactivity Able to Safely Perform Bronchial Provocation Tests?
Study Start Date : May 2013
Actual Primary Completion Date : May 2014
Actual Study Completion Date : May 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma

Arm Intervention/treatment
Experimental: asthma patients
patients who show a positive response at the first dos of histamine challenge test will be enrolled
Drug: histamine-benzylic alcohol (magistral preparation)
passive exposure to histamine during a bronchial hyperresponsiveness challenge




Primary Outcome Measures :
  1. spirometric values in patients exposed passively to histamine during BHR challenge [ Time Frame: 1 hour ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • adult patients with positive histamine challenge test (first dose)

Exclusion Criteria:

  • other active respiratory disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01937494


Locations
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Belgium
service de pneumologie, CHU St Pierre
Brussels, Belgium, 1000
Sponsors and Collaborators
Centre Hospitalier Universitaire Saint Pierre
Investigators
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Principal Investigator: Marie Bruyneel, MD CHU ST Pierre

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Responsible Party: Marie Bruyneel, CCA, pneumologie, Centre Hospitalier Universitaire Saint Pierre
ClinicalTrials.gov Identifier: NCT01937494     History of Changes
Other Study ID Numbers: AK/13-03-34/4235
First Posted: September 9, 2013    Key Record Dates
Last Update Posted: February 23, 2015
Last Verified: February 2015

Keywords provided by Marie Bruyneel, Centre Hospitalier Universitaire Saint Pierre:
asthma
bronchial hyperresponsiveness
histamine challenge test
spirometry

Additional relevant MeSH terms:
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Bronchial Hyperreactivity
Bronchial Diseases
Respiratory Tract Diseases
Histamine
Histamine phosphate
Benzyl Alcohol
Histamine Agonists
Histamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Anesthetics, Local
Anesthetics
Central Nervous System Depressants
Sensory System Agents
Peripheral Nervous System Agents