Bronchial Hyperreactivity During Histamine Passive Exposure
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|ClinicalTrials.gov Identifier: NCT01937494|
Recruitment Status : Completed
First Posted : September 9, 2013
Last Update Posted : February 23, 2015
|Condition or disease||Intervention/treatment||Phase|
|Asthma Bronchial Hyperresponsiveness||Drug: histamine-benzylic alcohol (magistral preparation)||Not Applicable|
Bronchial hyperresponsiveness (BHR) consists in excessive response to bronchial stimuli.Bronchial challenge test is used to confirm/exclude asthma.BHR is also present in other diseases such as allergic rhinitis, Chronic Obstructive pulmonary disease,heart failure..
Thes test is performed with metacholine or histamine with spirometric documented response to incremental doses.Protection are used to avoid passive exposure of the technicians performing the test, despite the absence of evidence that they could develop a bronchoconstriction if they suffer from BHR.
The purpose of the study is to determine if patients, newly diagnosed with a high level of bronchial hyperreactivity and exposed passively to histamine during a bronchial challenge, are reacting to histamine when placed in the same conditions that the technicians performing these tests.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||13 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Are Technicians Showing Bronchial Hyperreactivity Able to Safely Perform Bronchial Provocation Tests?|
|Study Start Date :||May 2013|
|Actual Primary Completion Date :||May 2014|
|Actual Study Completion Date :||May 2014|
Experimental: asthma patients
patients who show a positive response at the first dos of histamine challenge test will be enrolled
Drug: histamine-benzylic alcohol (magistral preparation)
passive exposure to histamine during a bronchial hyperresponsiveness challenge
- spirometric values in patients exposed passively to histamine during BHR challenge [ Time Frame: 1 hour ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01937494
|service de pneumologie, CHU St Pierre|
|Brussels, Belgium, 1000|
|Principal Investigator:||Marie Bruyneel, MD||CHU ST Pierre|