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Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction (PARAGON-HF)

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier:
NCT01920711
First received: August 8, 2013
Last updated: May 12, 2017
Last verified: May 2017
  Purpose
The purpose of this study is to evaluate the effect of LCZ696 compared to valsartan in the reduction of cardiovascular death and heart failure(HF) hospitalizations in patients with HF with preserved ejection fraction.

Condition Intervention Phase
Heart Failure With Preserved Ejection Fraction Drug: LCZ696 Drug: Valsartan Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Participant, Investigator
Primary Purpose: Treatment
Official Title: A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients (NYHA Class II-IV) With Preserved Ejection Fraction

Resource links provided by NLM:


Further study details as provided by Novartis ( Novartis Pharmaceuticals ):

Primary Outcome Measures:
  • Cumulative number of primary composite events of cardiovascular (CV) death and total (first and recurrent) HF hospitalizations. [ Time Frame: Total follow up time (up to 57 months) ]
    The primary objective of this study is to compare LCZ696 to valsartan in reducing the rate of the composite endpoint of CV death and total (first and recurrent) HF hospitalizations, in HF patients (New York Heart Association [NYHA] Class II-IV) with preserved ejection fraction (left ventricular ejection fraction [LVEF] ≥45%). The treatment arm with the lower rate of events will be deemed as having a successful response.


Secondary Outcome Measures:
  • Change in the clinical summary score from baseline to Month 8 by Kansas City Cardiomyopathy Questionnaire (KCCQ) [ Time Frame: Baseline, 8 months ]
    Evaluation of change from baseline to month 8 in KCCQ a most sensitive, specific, and responsive health-related quality of life measure for heart failure symptoms and physical limitations.

  • Change from baseline to Month 8 in New York Heart Association (NYHA) functional class [ Time Frame: Baseline, 8 months ]
    Evaluation of change from baseline to Month 8 in NYHA functional class, a well established grading scale used to classify a HF patients' level of functionality based on the signs and symptoms of HF exhibited by the patient.

  • Time to first occurance of a composite renal endpoint [ Time Frame: Total follow up time (up to 57 months) ]

    Evaluate significance of outcome modifying agents in worsening renal dysfunction.

    Composite renal endpoint defined as follows:

    • renal death, or
    • reaching ESRD, or
    • ≥50% decline in eGFR relative to baseline

  • Time to all-cause mortality [ Time Frame: Total follow up time (up to 57 months) ]
    Evaluation of the time to all cause death.


Enrollment: 4829
Actual Study Start Date: July 18, 2014
Estimated Study Completion Date: March 15, 2019
Estimated Primary Completion Date: March 15, 2019 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: LCZ696
Single Blind Run-in Period (3-8 weeks): Patients will start on Valsartan 80 mg b.i.d. for 1-2 weeks followed by LCZ696 100 mg b.i.d. for 2-4 weeks prior to randomization into the Double Blind period (up to 57 months). Patients can only be randomized from the run-in period if they meet all of the run-in safety criteria. Target dose of LCZ696 during the double blind period is 200 mg b.i.d.
Drug: LCZ696
LCZ696 50mg, 100mg and 200 mg dosage strengths will be available for dose adjustments.
Active Comparator: Valsartan
Single Blind Run-in Period (3-8 weeks): Patients will start on Valsartan 80 mg b.i.d. for 1-2 weeks followed by LCZ696 100 mg b.i.d. for 2-4 weeks prior to randomization into the Double Blind period (up to 57 months). Patients can only be randomized from the run-in period if they meet all of the run-in safety criteria. Target dose of Valsartan during the double blind period is 160 mg b.i.d.
Drug: Valsartan
Valsartan 40mg, 80mg and 160mg dosage strengths will be available for dose adjustments.

  Eligibility

Ages Eligible for Study:   50 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Left ventricular ejection fraction (LVEF) ≥45% by echo during screening epoch or within 6 months prior to study entry.
  • Symptom(s) of heart failure (HF) and requiring treatment with diuretic(s) for HF at least 30 days prior to study entry.
  • Current symptom(s) of HF
  • Structural heart disease (left atrial enlargement or left ventricular hypertrophy) documented by echocardiogram.
  • Elevated NT-proBNP

Exclusion Criteria:

  • Any prior measurement of LVEF < 40%.
  • Acute coronary syndrome (including MI), cardiac surgery, other major CV surgery within 3 months , or urgent percutaneous coronary intervention within 3 months or and elective PCI within 30 days prior to entry.
  • Any clinical event within the 6 months prior to entry could have reduced the LVEF (e.g., MI, CABG), unless an echo measurement performed after the event confirms a LVEF ≥45%.
  • Current acute decompensated HF requiring therapy.
  • Patients who require treatment with 2 or more of the following: an angiotensin converting enzyme inhibitor (ACEI), an angiotensin receptor blocker (ARB) or a renin inhibitor.
  • Alternative reason for shortness of breath such as: significant pulmonary disease or severe COPD, hemoglobin (Hgb) <10 g/dl, or body mass index (BMI) > 40 kg/m2.
  • Systolic blood pressure (SBP) ≥ 180 mmHg at entry, or SBP >150 mmHg and <180 mmHg at entry unless the patient is receiving 3 or more antihypertensive drugs, or SBP < 110 mmHg at entry.

Other protocol-defined inclusion/exclusion criteria may apply.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01920711

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Locations
United States, Alabama
Novartis Investigative Site
Huntsville, Alabama, United States, 35801
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Mobile, Alabama, United States, 36604
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Mobile, Alabama, United States, 36608
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Muscle Shoals, Alabama, United States, 35662
United States, Arizona
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Tucson, Arizona, United States, 85724
United States, Arkansas
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Little Rock, Arkansas, United States, 72204
United States, California
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Anaheim, California, United States, 92801
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Beverly Hills, California, United States, 90211
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Carmichael, California, United States, 95608
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Fresno, California, United States, 93720
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La Jolla, California, United States, 92037
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Los Angeles, California, United States, 90073
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Northridge, California, United States, 91325
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Oceanside, California, United States, 92056
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Orange, California, United States, 92868
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Palm Springs, California, United States, 92262
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San Diego, California, United States, 92161
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Santa Ana, California, United States, 92704
United States, Colorado
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Denver, Colorado, United States, 80220
United States, Connecticut
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Hartford, Connecticut, United States, 06105-2000
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Hartford, Connecticut, United States, 06105
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New Haven, Connecticut, United States, 06520-8062
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Stamford, Connecticut, United States, 06905
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West Haven, Connecticut, United States, 06516
United States, Florida
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Atlantis, Florida, United States, 33462
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Bradenton, Florida, United States, 34209
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DeFuniak Springs, Florida, United States, 32435
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Gainesville, Florida, United States, 32608
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Miami, Florida, United States, 33126
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Miami, Florida, United States, 33143
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Tallahassee, Florida, United States, 32308
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Atlanta, Georgia, United States, 30309
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Atlanta, Georgia, United States, 30310-1495
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Macon, Georgia, United States, 31201
United States, Illinois
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Chicago, Illinois, United States, 60611
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Chicago, Illinois, United States, 60612
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Chicago, Illinois, United States, 60637
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Evanston, Illinois, United States, 60201
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Hazel Crest, Illinois, United States, 60429
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Lombard, Illinois, United States, 60148
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Boston, Massachusetts, United States, 02114
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Saint Louis, Missouri, United States, 63136
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Kalispell, Montana, United States, 59901 3158
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Lincoln, Nebraska, United States, 68506
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Morristown, New Jersey, United States, 07960
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New Brunswick, New Jersey, United States, 08901
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Ridgewood, New Jersey, United States, 07450
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Albuquerque, New Mexico, United States, 87102
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Brooklyn, New York, United States, 11215-9008
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Buffalo, New York, United States, 14215
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Flushing, New York, United States, 11355
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Kingston, New York, United States, 12401
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Rochester, New York, United States, 14642
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Chapel Hill, North Carolina, United States, 27599-7075
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Grand Forks, North Dakota, United States, 58201
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Canton, Ohio, United States, 44710
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Providence, Rhode Island, United States, 02908
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Charleston, South Carolina, United States, 29403
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Rapid City, South Dakota, United States, 57701
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Sioux Falls, South Dakota, United States, 57104
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Knoxville, Tennessee, United States, 37917
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Nashville, Tennessee, United States, 37203
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Nashville, Tennessee, United States, 37212
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Beaumont, Texas, United States, 77702
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Dallas, Texas, United States, 75204
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Dallas, Texas, United States, 75216
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Dallas, Texas, United States, 75231
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Dallas, Texas, United States, 75235
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Houston, Texas, United States, 77030
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Houston, Texas, United States, 77094
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Livingston, Texas, United States, 77351
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McKinney, Texas, United States, 75069
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San Antonio, Texas, United States, 78234
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Tomball, Texas, United States, 77375
United States, Utah
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Salt Lake City, Utah, United States, 84124
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Salt Lake City, Utah, United States, 84132
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White River Junction, Vermont, United States, 05009
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Richmond, Virginia, United States, 23298
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Seattle, Washington, United States, 98103
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Seattle, Washington, United States, 98195
United States, Wisconsin
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Madison, Wisconsin, United States, 53705
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Madison, Wisconsin, United States, 53792-1615
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Milwaukee, Wisconsin, United States, 53215
Argentina
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Caba, Buenos Aires, Argentina, 1407
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Caba, Buenos Aires, Argentina, C1056ABJ
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Caba, Buenos Aires, Argentina, C1280AEB
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Quilmes, Buenos Aires, Argentina, B1878GEG
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Ramos Mejia, Buenos Aires, Argentina, B1704ETD
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Caba, Capital Federal, Argentina, C1179AAB
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Posadas, Misiones, Argentina, N3300AHX
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Ciudad de Salta, Provincia de Salta, Argentina, A4406BPF
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Tucuman, San Miguel de Tucuman, Argentina, T4000ICL
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Rosario, Santa Fe, Argentina, 2000
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Rosario, Santa Fe, Argentina, 3080
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Rosario, Santa Fe, Argentina, S2000DSV
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San Miguel de Tucuman, Tucuman, Argentina, T4000IFL
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Buenos Aires, Argentina, C1405CNF
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Buenos Aires, Argentina, C1425AGP
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Buenos Aires, Argentina, C1428DCO
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Caba, Argentina, C1119ACN
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Cordoba, Argentina, X5000AAX
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Cordoba, Argentina, X5000EVQ
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Cordoba, Argentina, X5003DCE
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Cordoba, Argentina, X5006CBI
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Cordoba, Argentina, X5009BSN
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Cordoba, Argentina, X5016KET
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Cordoba, Argentina, X5022CPU
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Corrientes, Argentina, W3400CBI
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Formosa, Argentina, P3600
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Salta, Argentina, 4400
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San Luis, Argentina, D5702JRS
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Santa Fe, Argentina, S3000FWO
Australia, New South Wales
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Gosford, New South Wales, Australia, 2250
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North Ryde, New South Wales, Australia, 2109
Australia, Queensland
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Auchenflower, Queensland, Australia, 4066
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Southport, Queensland, Australia, 4215
Australia, South Australia
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Bedford Park, South Australia, Australia, 5042
Australia, Victoria
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Bundoora, Victoria, Australia, 3083
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Epping, Victoria, Australia, 3076
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Geelong, Victoria, Australia, 3220
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Heidelberg, Victoria, Australia, 3084
Austria
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Innsbruck, Tyrol, Austria, 6020
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Braunau, Austria, A5280
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Graz, Austria, 8020
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Graz, Austria, A-8036
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Großgmain, Austria, 5084
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Linz, Austria, 4010
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Vienna, Austria, 1130
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Wien, Austria, A-1090
Belgium
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Aalst, Belgium, 9300
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Antwerpen, Belgium, 2060
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Brasschaat, Belgium, 2930
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Brussel, Belgium, 1000
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Bruxelles, Belgium, 1200
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De Pinte, Belgium, 9840
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Genk, Belgium, 3600
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Gent, Belgium, 9000
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Hasselt, Belgium, 3500
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Huy, Belgium, 4500
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Kortrijk, Belgium, 8500
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Leuven, Belgium, 3000
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Ottignies, Belgium, 1340
Brazil
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Goiania, GO, Brazil, 74605-020
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Belo Horizonte, MG, Brazil, 30150-221
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Uberlandia, Minas Gerais, Brazil, 38411 186
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Curitiba, Parana, Brazil, 80730 150
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Campina Grande do Sul, PR, Brazil, 83430-000
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Porto Alegre, RS, Brazil, 90035-003
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Porto Alegre, RS, Brazil, 90560-030
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Porto Alegre, RS, Brazil, 90880-480
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Porto Alegre, RS, Brazil, 91350-200
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Liberdade, Sao Paulo, Brazil, 01504-001
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Blumenau, SC, Brazil, 89010 500
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Campinas, SP, Brazil, 13020-431
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Campinas, SP, Brazil, 13060-904
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Ribeirao Preto, SP, Brazil, 14055-370
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Sao Jose do Rio Preto, SP, Brazil, 15090 000
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São Paulo, SP, Brazil, 08270-070
Bulgaria
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Burgas, Bulgaria, 8127
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Pazardzhik, Bulgaria, 4400
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Pleven, Bulgaria, 5800
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Plovdiv, Bulgaria, 4000
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Plovdiv, Bulgaria, 4002
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Shumen, Bulgaria, 9700
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Silistra, Bulgaria, 7500
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Sliven, Bulgaria, 8800
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Smolian, Bulgaria, 4700
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Sofia, Bulgaria, 1000
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Sofia, Bulgaria, 1202
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Sofia, Bulgaria, 1233
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Sofia, Bulgaria, 1309
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Sofia, Bulgaria, 1407
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Sofia, Bulgaria, 1527
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Sofia, Bulgaria, 1606
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Sofia, Bulgaria, 1784
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Varna, Bulgaria, 9010
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Veliko Tarnovo, Bulgaria, 5000
Canada, Alberta
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Calgary, Alberta, Canada, T2N 4Z6
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Victoria, British Columbia, Canada, V8R4R2
Canada, Newfoundland and Labrador
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St. John, Newfoundland and Labrador, Canada, A1B 3V6
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Halifax, Nova Scotia, Canada, B3H 2Y9
Canada, Ontario
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Cambridge, Ontario, Canada, N1R 6V6
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Hamilton, Ontario, Canada, L8L 2X2
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Ottawa, Ontario, Canada, K1Y 4W7
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Toronto, Ontario, Canada, M5B 1W8
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Toronto, Ontario, Canada, M5G 1X5
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Toronto, Ontario, Canada, M5S 1B2
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Weston, Ontario, Canada, M9N 1W4
Canada, Quebec
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Montreal, Quebec, Canada, H1T 1C8
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Montreal, Quebec, Canada, H2W 1T8
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Montreal, Quebec, Canada, H2X 3J4
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Montreal, Quebec, Canada, H3G 1A4
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Sainte-Foy, Quebec, Canada, G1V 4G5
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Sherbrooke, Quebec, Canada, J1G 2E8
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Thetford Mines, Quebec, Canada, G6G 2V4
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Trois-Rivieres, Quebec, Canada, G8Z 3R9
China, Beijing
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Beijing, Beijing, China, 100037
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Beijing, Beijing, China, 100044
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Beijing, Beijing, China, 100730
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Beijing, Beijing, China, 100853
China, Chongqing
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Chongqing, Chongqing, China, 400010
China, Gansu
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Lanzhou, Gansu, China, 730030
China, Guangdong
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Guangzhou, Guangdong, China, 510080
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Guangzhou, Guangdong, China, 510515
China, Guangxi
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Nanning, Guangxi, China, 530021
China, Hunan
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Changsha, Hunan, China, 410003
China, Jiangsu
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Nanjing, Jiangsu, China, 210009
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Nanjing, Jiangsu, China, 210029
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Suzhou, Jiangsu, China, 215004
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Wuxi, Jiangsu, China
China, Jiangxi
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Nanchang, Jiangxi, China, 330006
China, Jilin
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Changchun, Jilin, China, 130022
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Jilin, Jilin, China, 132000
China, Liaoning
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Shenyang, Liaoning, China, 110003
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Shenyang, Liaoning, China, 110016
China, Shanghai
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Shanghai City, Shanghai, China, 200120
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Shanghai, Shanghai, China
China, Shanxi
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Xi'an, Shanxi, China, 710032
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Xian, Shanxi, China, 710061
China, Sichuan
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Chengdu, Sichuan, China, 610041
China, Tianjin
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Tianjin, Tianjin, China, 300121
China, Zhejiang
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Hangzhou, Zhejiang, China, 310009
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Hangzhou, Zhejiang, China, 310013
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Hangzhou, Zhejiang, China, 310016
China
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Beijing, China, 100029
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Beijing, China, 100034
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Chongqing, China, 400037
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Jinan, China, 250012
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Nanjing, China, 210036
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Shanghai, China, 200025
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Shanghai, China, 200031
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Shanghai, China, 200032
Novartis Investigative Site
Shanghai, China, 200080
Novartis Investigative Site
Urumqi, China, 830054
Colombia
Novartis Investigative Site
Medellin, Antioquia, Colombia, 050036
Novartis Investigative Site
Barranquilla, Atlantico, Colombia
Novartis Investigative Site
Barranquilla, Colombia, 080020
Novartis Investigative Site
Barranquilla, Colombia
Novartis Investigative Site
Bogota, Colombia
Novartis Investigative Site
Florida Blanca, Colombia
Croatia
Novartis Investigative Site
Varazdin, HRV, Croatia, 42000
Novartis Investigative Site
Rijeka, Croatia, 51000
Novartis Investigative Site
Zadar, Croatia, 23000
Novartis Investigative Site
Zagreb, Croatia, 10000
Czechia
Novartis Investigative Site
Brandys nad Labem, Czech Republic, Czechia, 250 01
Novartis Investigative Site
Brno, Czech Republic, Czechia, 60200
Novartis Investigative Site
Chomutov, Czech Republic, Czechia, 43002
Novartis Investigative Site
Ivancice, Czech Republic, Czechia, 66491
Novartis Investigative Site
Kladno, Czech Republic, Czechia, 272 80
Novartis Investigative Site
Liberec, Czech Republic, Czechia, 460 05
Novartis Investigative Site
Louny, Czech Republic, Czechia
Novartis Investigative Site
Ostrava, Czech Republic, Czechia, 70200
Novartis Investigative Site
Plzen, Czech Republic, Czechia, 30100
Novartis Investigative Site
Praha 11, Czech Republic, Czechia, 148 00
Novartis Investigative Site
Praha 4, Czech Republic, Czechia, 140 21
Novartis Investigative Site
Roznov pod Radhostem, Czech Republic, Czechia, 756 61
Novartis Investigative Site
Svitavy, Czech Republic, Czechia, 568 25
Novartis Investigative Site
Trebic, Czech Republic, Czechia, 674 01
Novartis Investigative Site
Usti nad Labem, Czech Republic, Czechia, 400 01
Novartis Investigative Site
Znojmo, Czech Republic, Czechia, 66902
Novartis Investigative Site
Policska, CZE, Czechia, 57201
Novartis Investigative Site
Praha 2, CZE, Czechia, 128 08
Novartis Investigative Site
Usti nad Labem, CZE, Czechia, 400 01
Novartis Investigative Site
CZE, Czechia, 11000
Novartis Investigative Site
Kolin, Czechia, 280 20
Novartis Investigative Site
Marianske lazne, Czechia, 353 01
Novartis Investigative Site
Uherske Hradiste, Czechia, 68601
Denmark
Novartis Investigative Site
Copenhagen, Denmark, 2100
Novartis Investigative Site
Esbjerg, Denmark, DK-6700
Novartis Investigative Site
Herlev, Denmark, 2730
Novartis Investigative Site
Hvidovre, Denmark, 2650
Novartis Investigative Site
Randers, Denmark, 8930
Novartis Investigative Site
Svendborg, Denmark, 5700
Novartis Investigative Site
Viborg, Denmark, DK-8800
Finland
Novartis Investigative Site
Espoo, Finland, 02740
Novartis Investigative Site
Jyvaskyla, Finland, 40620
Novartis Investigative Site
Oulu, Finland, 90220
Novartis Investigative Site
Tampere, Finland, 33520
France
Novartis Investigative Site
Bayonne, Bayonne cedex, France, 64109
Novartis Investigative Site
Besancon Cedex, France, 25030
Novartis Investigative Site
Beziers Cedex, France, 34525
Novartis Investigative Site
Bordeaux Cedex, France, 33075
Novartis Investigative Site
Grenoble, France, 38043
Novartis Investigative Site
Le Kremlin Bicetre, France, 94275
Novartis Investigative Site
Lille Cedex, France, 59000
Novartis Investigative Site
Lyon, France, F-69001
Novartis Investigative Site
Montpellier, France, 34059
Novartis Investigative Site
Paris cedex 10, France, 75010
Novartis Investigative Site
Poitiers, France, 86000
Novartis Investigative Site
Pontoise, France, F-95300
Novartis Investigative Site
Rennes Cedex 9, France, 35033
Novartis Investigative Site
Toulouse Cedex, France, 31059
Novartis Investigative Site
Tourcoing, France, 59208
Novartis Investigative Site
Vandoeuvre Les Nancy, France, 54511
Germany
Novartis Investigative Site
Aachen, Germany, 52074
Novartis Investigative Site
Bad Homburg, Germany, 61348
Novartis Investigative Site
Bad Krozingen, Germany, 79189
Novartis Investigative Site
Bamberg, Germany, 96049
Novartis Investigative Site
Berlin-Buch, Germany, 13125
Novartis Investigative Site
Berlin, Germany, 10249
Novartis Investigative Site
Berlin, Germany, 10789
Novartis Investigative Site
Berlin, Germany, 10967
Novartis Investigative Site
Berlin, Germany, 12203
Novartis Investigative Site
Berlin, Germany, 12683
Novartis Investigative Site
Berlin, Germany, 13086
Novartis Investigative Site
Berlin, Germany, 13353
Novartis Investigative Site
Berlin, Germany, 13405
Novartis Investigative Site
Chemnitz, Germany, 09126
Novartis Investigative Site
Chemnitz, Germany, 09130
Novartis Investigative Site
Dessau-Roßlau, Germany, 06846
Novartis Investigative Site
Dietzenbach, Germany, 63128
Novartis Investigative Site
Dinkelsbühl, Germany, 91550
Novartis Investigative Site
Dresden, Germany, 01099
Novartis Investigative Site
Dresden, Germany, 01277
Novartis Investigative Site
Dresden, Germany, 01307
Novartis Investigative Site
Dresden, Germany, 01309
Novartis Investigative Site
Duisburg, Germany, 47137
Novartis Investigative Site
Eilenburg, Germany, D 04838
Novartis Investigative Site
Elsterwerda, Germany, 04910
Novartis Investigative Site
Essen, Germany, 45355
Novartis Investigative Site
Frankfurt, Germany, 60488
Novartis Investigative Site
Frankfurt, Germany, 60594
Novartis Investigative Site
Frankfurt, Germany, 65929
Novartis Investigative Site
Goettingen, Germany, 37075
Novartis Investigative Site
Hamburg, Germany, 20099
Novartis Investigative Site
Hamburg, Germany, 20246
Novartis Investigative Site
Hamburg, Germany, 22041
Novartis Investigative Site
Hamburg, Germany, 22765
Novartis Investigative Site
Hassloch, Germany, 67454
Novartis Investigative Site
Heidenau, Germany, 01809
Novartis Investigative Site
Heide, Germany, 25746
Novartis Investigative Site
Heppenheim, Germany, 64646
Novartis Investigative Site
Homburg, Germany, 66421
Novartis Investigative Site
Ingelheim, Germany, 55218
Novartis Investigative Site
Jena, Germany, 07740
Novartis Investigative Site
Kassel, Germany, 34121
Novartis Investigative Site
Kleve, Germany, 47533
Novartis Investigative Site
Koblenz, Germany, 56068
Novartis Investigative Site
Koeln, Germany, 51605
Novartis Investigative Site
Leipzig, Germany, 04103
Novartis Investigative Site
Loehne, Germany, 32584
Novartis Investigative Site
Ludwigsburg, Germany, 71634
Novartis Investigative Site
Ludwigshafen, Germany, 67071
Novartis Investigative Site
Lutherstadt Wittenberg, Germany, 06886
Novartis Investigative Site
Lüneburg, Germany, 21339
Novartis Investigative Site
Mainz, Germany, 55116
Novartis Investigative Site
Mannheim, Germany, 68165
Novartis Investigative Site
Markkleeberg, Germany, 04416
Novartis Investigative Site
Meißen, Germany, 01662
Novartis Investigative Site
Memmingen, Germany, 87700
Novartis Investigative Site
Muehldorf am Inn, Germany, 84453
Novartis Investigative Site
Muehldorf, Germany, 84453
Novartis Investigative Site
Muehlheim an der Ruhr, Germany, 45468
Novartis Investigative Site
Muenster, Germany, 48149
Novartis Investigative Site
Munchen, Germany, 80992
Novartis Investigative Site
Munich, Germany, 80638
Novartis Investigative Site
Nienburg, Germany, 31582
Novartis Investigative Site
Northeim, Germany, 37154
Novartis Investigative Site
Nurnberg, Germany, 90402
Novartis Investigative Site
Oschatz, Germany, 04758
Novartis Investigative Site
Papenburg, Germany, 26871
Novartis Investigative Site
Reinfeld, Germany, 23858
Novartis Investigative Site
Riesa, Germany, 01589
Novartis Investigative Site
Rodgau, Germany, 63110
Novartis Investigative Site
Siegen, Germany, 57072
Novartis Investigative Site
Ulm, Germany, 89077
Novartis Investigative Site
Vilshofen, Germany, 94474
Novartis Investigative Site
Wangen, Germany, 88239
Novartis Investigative Site
Wermsdorf, Germany, 04779
Novartis Investigative Site
Weyhe, Germany, 28844
Novartis Investigative Site
Witten, Germany, 58455
Novartis Investigative Site
Wuerzburg, Germany, 97078
Greece
Novartis Investigative Site
Ioannina, GR, Greece, 451 10
Novartis Investigative Site
Larissa, GR, Greece, 411 10
Novartis Investigative Site
Athens, Greece, 115 27
Novartis Investigative Site
Athens, Greece, 155 62
Novartis Investigative Site
Athens, Greece, GR 14233
Novartis Investigative Site
Chaidari, Greece, 12461
Novartis Investigative Site
Thessaloniki, Greece, 54636
Novartis Investigative Site
Thessaloniki, Greece, 54642
Guatemala
Novartis Investigative Site
Guatemala City, Guatemala, 01010
Novartis Investigative Site
Guatemala City, Guatemala, 01011
Novartis Investigative Site
Guatemala City, Guatemala, 01015
Novartis Investigative Site
Guatemala City, Guatemala, 10110
Novartis Investigative Site
Quetzaltenango, Guatemala, 09001
Hungary
Novartis Investigative Site
Budapest, Hungary, 1042
Novartis Investigative Site
Budapest, Hungary, 1085
Novartis Investigative Site
Budapest, Hungary, 1134
Novartis Investigative Site
Budapest, Hungary, 1145
Novartis Investigative Site
Budapest, Hungary, H 1096
Novartis Investigative Site
Cegled, Hungary, 2700
Novartis Investigative Site
Kistarcsa, Hungary, 2143
Novartis Investigative Site
Mako, Hungary, 6900
Novartis Investigative Site
Mohacs, Hungary, 7700
Novartis Investigative Site
Nyiregyháza, Hungary, 4400
Novartis Investigative Site
Pecs, Hungary, 7623
Novartis Investigative Site
Pecs, Hungary, 7624
Novartis Investigative Site
Pécs, Hungary, 7623
Novartis Investigative Site
Szeged, Hungary, H-6725
Novartis Investigative Site
Szekesfehervar, Hungary, H-8000
Novartis Investigative Site
Zalaegerszeg, Hungary, 8900
India
Novartis Investigative Site
Guntur, Andhra Pradesh, India, 522001
Novartis Investigative Site
Vishakhapatnam, Andhra Pradesh, India, 532 002
Novartis Investigative Site
New Delhi, Delhi, India, 110 060
Novartis Investigative Site
Surat, Gujarat, India, 395 002
Novartis Investigative Site
Chandigarh, Haryana, India, 160 030
Novartis Investigative Site
Gurgaon, Haryana, India, 122001
Novartis Investigative Site
Bangalore, Karnataka, India, 560 002
Novartis Investigative Site
Kochi, Kerala, India, 683 594
Novartis Investigative Site
Pune, Maharashtra, India, 411 030
Novartis Investigative Site
Ludhiana, Punjab, India, 141002
Novartis Investigative Site
Bikaner, Rajasthan, India, 334003
Novartis Investigative Site
Chennai, Tamil Nadu, India, 600037
Novartis Investigative Site
Chennai, Tamil Nadu, India, 600081
Novartis Investigative Site
Madurai, Tamil Nadu, India, 625107
Novartis Investigative Site
Kolkata, West Bengal, India, 700 020
Novartis Investigative Site
Ahmedabad, India, 380052
Novartis Investigative Site
New Delhi, India, 110025
Israel
Novartis Investigative Site
Hadera, Israel, 38100
Novartis Investigative Site
Hadera, Israel
Novartis Investigative Site
Haifa, Israel, 3339419
Novartis Investigative Site
Haifa, Israel, 3525408
Novartis Investigative Site
Lower Galilee, Israel, 15208
Novartis Investigative Site
Nahariya, Israel, 22100
Novartis Investigative Site
Petach Tikva, Israel, 49100
Novartis Investigative Site
Ramat Gan, Israel, 5266202
Novartis Investigative Site
Rehovot, Israel, 76100
Novartis Investigative Site
Tel Giborim, Holon, Israel, 58100
Italy
Novartis Investigative Site
Aosta, AO, Italy, 11100
Novartis Investigative Site
Cortona, AR, Italy, 52044
Novartis Investigative Site
Bergamo, BG, Italy, 24127
Novartis Investigative Site
Treviglio, BG, Italy, 24047
Novartis Investigative Site
Bologna, BO, Italy, 40138
Novartis Investigative Site
Brescia, BS, Italy, 25123
Novartis Investigative Site
San Fermo della Battaglia, CO, Italy, 22020
Novartis Investigative Site
Cona, FE, Italy, 44100
Novartis Investigative Site
Pozzilli, IS, Italy, 86077
Novartis Investigative Site
Monza, MB, Italy, 20900
Novartis Investigative Site
Messina, ME, Italy, 98125
Novartis Investigative Site
Milano, MI, Italy, 20162
Novartis Investigative Site
Vimercate, MI, Italy, 200059
Novartis Investigative Site
Palermo, PA, Italy, 90146
Novartis Investigative Site
Piacenza, PC, Italy, 29100
Novartis Investigative Site
Padova, PD, Italy, 35128
Novartis Investigative Site
Perugia, PG, Italy, 06100
Novartis Investigative Site
Perugia, PG, Italy, 06129
Novartis Investigative Site
Pavia, PV, Italy, 27100
Novartis Investigative Site
Albano Laziale, RM, Italy, 00041
Novartis Investigative Site
Roma, RM, Italy, 00163
Novartis Investigative Site
Roma, RM, Italy, 00189
Novartis Investigative Site
Sassari, SS, Italy, 07100
Novartis Investigative Site
Trieste, TS, Italy, 34142
Novartis Investigative Site
Trieste, TS, Italy, 34149
Novartis Investigative Site
Vittorio Veneto, TV, Italy, 31029
Novartis Investigative Site
Palmanova, UD, Italy, 33057
Novartis Investigative Site
San Daniele Del Friuli, UD, Italy, 33038
Novartis Investigative Site
Saronno, Va, Italy, 21047
Novartis Investigative Site
Venezia, VE, Italy, 30174
Novartis Investigative Site
Milano, Italy, 20149
Novartis Investigative Site
Napoli, Italy, 80131
Novartis Investigative Site
Novara, Italy, 28100
Japan
Novartis Investigative Site
Seto-city, Aichi, Japan, 489-8642
Novartis Investigative Site
Chikushino-city, Fukuka, Japan, 818-8516
Novartis Investigative Site
Ogaki-city, Gifu, Japan, 503-8502
Novartis Investigative Site
Maebashi-city, Gunma, Japan, 371-8511
Novartis Investigative Site
Amagasaki-city, Hyogo, Japan, 660-8550
Novartis Investigative Site
Kanazawa, Ishikawa, Japan, 920-8650
Novartis Investigative Site
Morioka, Iwate, Japan, 020-0066
Novartis Investigative Site
Kanonji-city, Kagawa, Japan, 769-1695
Novartis Investigative Site
Takamatsu-city, Kagawa, Japan, 760-8557
Novartis Investigative Site
Yokohama-city, Kanagawa, Japan, 227-8501
Novartis Investigative Site
Yokohama-city, Kanagawa, Japan, 236-0051
Novartis Investigative Site
Sendai-city, Miyagi, Japan, 980-8574
Novartis Investigative Site
Sendai-city, Miyagi, Japan, 981-3133
Novartis Investigative Site
Kashihara-city, Nara, Japan, 634-8522
Novartis Investigative Site
Oita-city, Oita, Japan, 870-0192
Novartis Investigative Site
Sayama-city, Saitama, Japan, 350-1305
Novartis Investigative Site
Kusatsu-city, Shiga, Japan, 525-8585
Novartis Investigative Site
Chiyoda-ku, Tokyo, Japan, 101-8309
Novartis Investigative Site
Hachioji-city, Tokyo, Japan, 192-0918
Novartis Investigative Site
Itabashi-ku, Tokyo, Japan, 173-8610
Novartis Investigative Site
Shinagawa-ku, Tokyo, Japan, 142-8666
Korea, Republic of
Novartis Investigative Site
Gyeonggi-do, Bucheon-si, Korea, Republic of, 422-711
Novartis Investigative Site
Cheongju-si, Chungcheongbuk-do, Korea, Republic of, 28644
Novartis Investigative Site
Wonju, Gangwon-do, Korea, Republic of, 26427
Novartis Investigative Site
Suwon, Gyeonggi-do, Korea, Republic of, 442-723
Novartis Investigative Site
Seongnam, Gyeonggi, Korea, Republic of, 13620
Novartis Investigative Site
Seoul, Korea, Korea, Republic of, 03080
Novartis Investigative Site
Seoul, Korea, Korea, Republic of, 05505
Novartis Investigative Site
Seoul, Korea, Korea, Republic of, 06351
Novartis Investigative Site
Daegu, Korea, Republic of, 705-718
Novartis Investigative Site
Incheon, Korea, Republic of, 22332
Novartis Investigative Site
Seoul, Korea, Republic of, 08308
Novartis Investigative Site
Seoul, Korea, Republic of, 120-752
Novartis Investigative Site
Seoul, Korea, Republic of, 136-705
Mexico
Novartis Investigative Site
Torreon, Coahulia, Mexico, 27000
Novartis Investigative Site
Mexico, Distrito Federal, Mexico, 14080
Novartis Investigative Site
Leon, Guanajuato, Mexico, 37530
Novartis Investigative Site
Zapopan, Jalisco, Mexico, 45200
Novartis Investigative Site
San Juan del Rio, Queretaro, Mexico, 76800
Novartis Investigative Site
San Luis Potosi, San Luis Potosí, Mexico, 78240
Novartis Investigative Site
Culiacan, Sinaloa, Mexico, CP:83230
Novartis Investigative Site
Aguascalientes, Mexico, 20230
Novartis Investigative Site
Queretaro, Mexico, 76000
Novartis Investigative Site
San Luis Potosi, Mexico, 78200
Novartis Investigative Site
San Luis Potosí, Mexico, 78200
Netherlands
Novartis Investigative Site
Den Haag, NL, Netherlands, 2597 AX
Novartis Investigative Site
Almelo, PP, Netherlands, 7609
Novartis Investigative Site
Apeldoorn, Netherlands, 7334 DZ
Novartis Investigative Site
Arnhem, Netherlands, 6815 AD
Novartis Investigative Site
Blaricum, Netherlands, 1261 AN
Novartis Investigative Site
Den Haag, Netherlands, 2512 VA
Novartis Investigative Site
Ede, Netherlands, 6716 RP
Novartis Investigative Site
Gouda, Netherlands, 2800 BB
Novartis Investigative Site
Groningen, Netherlands, 9713 GZ
Novartis Investigative Site
Hardenberg, Netherlands, 7770 AA
Novartis Investigative Site
Harderwijk, Netherlands, 3840 AC
Novartis Investigative Site
Nijmegen, Netherlands, 6525 GA
Novartis Investigative Site
Rotterdam, Netherlands, 3015 CE
Novartis Investigative Site
Sneek, Netherlands, 8601 ZK
Novartis Investigative Site
Tilburg, Netherlands, 5022 GC
Novartis Investigative Site
Zwolle, Netherlands, 8025 AB
Norway
Novartis Investigative Site
Hønefoss, Norway, 3501
Novartis Investigative Site
Loerenskog, Norway, NO-1478
Novartis Investigative Site
Oslo, Norway, 0407
Novartis Investigative Site
Stavanger, Norway, 4068
Novartis Investigative Site
Tromsoe, Norway, NO-9038
Peru
Novartis Investigative Site
Bellavista, Lima, Peru, Callao 02
Novartis Investigative Site
Cercado de Lima, Lima, Peru, 01
Novartis Investigative Site
Jesus Maria, Lima, Peru, 11
Novartis Investigative Site
Miraflores, Lima, Peru, 18
Novartis Investigative Site
San Isidro, Lima, Peru, 27
Philippines
Novartis Investigative Site
Lipa City, Batangas, Philippines, 4217
Novartis Investigative Site
Quezon City, Manila, Philippines, 1100
Novartis Investigative Site
Quezon City, Philippines, 1100
Novartis Investigative Site
Quezon City, Philippines, 1102
Poland
Novartis Investigative Site
Gdansk, Poland, 80-141
Novartis Investigative Site
Gdynia, Poland, 81-157
Novartis Investigative Site
Gdynia, Poland, 81-548
Novartis Investigative Site
Grodzisk Mazowiecki, Poland, 05-825
Novartis Investigative Site
Katowice, Poland, 40-645
Novartis Investigative Site
Krakow, Poland, 30-015
Novartis Investigative Site
Krakow, Poland, 31 501
Novartis Investigative Site
Lodz, Poland, 92-213
Novartis Investigative Site
Lublin, Poland, 20-363
Novartis Investigative Site
Piaseczno, Poland, 05-500
Novartis Investigative Site
Sandomierz, Poland, 27-600
Novartis Investigative Site
Staszów, Poland, 28-200
Novartis Investigative Site
Torun, Poland, 87-100
Novartis Investigative Site
Warszawa/Anin, Poland, 04-761
Novartis Investigative Site
Warszawa, Poland, 02-097
Novartis Investigative Site
Warszawa, Poland, 04-154
Novartis Investigative Site
Zabrze, Poland, 41-800
Novartis Investigative Site
Zamosc, Poland, 22-400
Romania
Novartis Investigative Site
Pitesti, Arges, Romania, 110438
Novartis Investigative Site
Bucuresti, District 1, Romania, 014461
Novartis Investigative Site
Craiova, Jud. Dolj, Romania, 200497
Novartis Investigative Site
Sibiu, Jud. Iasi, Romania, 550371
Novartis Investigative Site
Braila, ROM, Romania, 810249
Novartis Investigative Site
Timisoara, Timis, Romania, 300125
Novartis Investigative Site
Timisoara, Timis, Romania, 300359
Novartis Investigative Site
Arad, Romania, 310158
Novartis Investigative Site
Baia Mare, Romania, 430222
Novartis Investigative Site
Bucharest, Romania, 050098
Novartis Investigative Site
Bucuresti, Romania, 062272
Novartis Investigative Site
Oradea, Romania, 410169
Novartis Investigative Site
Targu Mures, Romania, 540142
Novartis Investigative Site
Targu Mures, Romania, 540143
Novartis Investigative Site
Timisoara, Romania, 300041
Novartis Investigative Site
Timisoara, Romania, 300079
Russian Federation
Novartis Investigative Site
Chelyabinsk, Russian Federation, 454021
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620028
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620137
Novartis Investigative Site
Ivanovo, Russian Federation, 153012
Novartis Investigative Site
Izhevsk, Russian Federation, 426009
Novartis Investigative Site
Izhevsk, Russian Federation, 426063
Novartis Investigative Site
Kemerovo, Russian Federation, 650029
Novartis Investigative Site
Kemerovo, Russian Federation, 650099
Novartis Investigative Site
Kirov, Russian Federation, 610014
Novartis Investigative Site
Kirov, Russian Federation, 610027
Novartis Investigative Site
Moscow, Russian Federation, 101990
Novartis Investigative Site
Moscow, Russian Federation, 117198
Novartis Investigative Site
Moscow, Russian Federation, 121309
Novartis Investigative Site
Moscow, Russian Federation, 121552
Novartis Investigative Site
N.Novgorod, Russian Federation, 603005
Novartis Investigative Site
Perm, Russian Federation, 614990
Novartis Investigative Site
Rostov-on-Don, Russian Federation, 344022
Novartis Investigative Site
Rostov-on-Don, Russian Federation, 344068
Novartis Investigative Site
Saint Petersburg, Russian Federation, 197022
Novartis Investigative Site
Saint Petersburg, Russian Federation, 197341
Novartis Investigative Site
Saint Petersburg, Russian Federation, 199106
Novartis Investigative Site
Saint-Petersburg, Russian Federation, 194044
Novartis Investigative Site
Saint-Petersburg, Russian Federation, 195257
Novartis Investigative Site
Saratov, Russian Federation, 410012
Novartis Investigative Site
Smolensk, Russian Federation, 214018
Novartis Investigative Site
St Petersburg, Russian Federation, 196601
Novartis Investigative Site
St-Petersburg, Russian Federation, 194295
Novartis Investigative Site
St. Petersburg, Russian Federation, 197706
Novartis Investigative Site
St.- Petersburg, Russian Federation, 197110
Novartis Investigative Site
Yaroslavl, Russian Federation, 150003
Serbia
Novartis Investigative Site
Belgrade, Serbia, 11000
Novartis Investigative Site
Beograd, Serbia, 11040
Novartis Investigative Site
Niska Banja, Serbia, 18205
Novartis Investigative Site
Nis, Serbia, 18000
Singapore
Novartis Investigative Site
Singapore, Singapore, 119074
Novartis Investigative Site
Singapore, Singapore, 169609
Novartis Investigative Site
Singapore, Singapore, 308433
Novartis Investigative Site
Singapore, Singapore, 529889
Novartis Investigative Site
Singapore, Singapore, 768825
Slovakia
Novartis Investigative Site
Brezno, Slovak Republic, Slovakia, 977 42
Novartis Investigative Site
Komarno, Slovak Republic, Slovakia, 94575
Novartis Investigative Site
Levice, Slovak Republic, Slovakia, 93401
Novartis Investigative Site
Namestovo, Slovak Republic, Slovakia, 02901
Novartis Investigative Site
Povazska Bystrica, Slovak republic, Slovakia, 01701
Novartis Investigative Site
Presov, Slovak Republic, Slovakia, 08001
Novartis Investigative Site
Velky Krtis, Slovak Republic, Slovakia, 990 01
Novartis Investigative Site
Bardejov, Slovakia, 085 01
Novartis Investigative Site
Bratislava, Slovakia, 821 07
Novartis Investigative Site
Bratislava, Slovakia, 831 01
Novartis Investigative Site
Bratislava, Slovakia, 833 48
Novartis Investigative Site
Bratislava, Slovakia, 841 07
Novartis Investigative Site
Bratislava, Slovakia, 842 31
Novartis Investigative Site
Bratislava, Slovakia, 851 01
Novartis Investigative Site
Kosice, Slovakia, 040 01
Novartis Investigative Site
Levice, Slovakia, 934 01
Novartis Investigative Site
Lucenec, Slovakia, 984 01
Novartis Investigative Site
Lucenec, Slovakia, 98439
Novartis Investigative Site
Nitra, Slovakia, 949 01
Novartis Investigative Site
Nitra, Slovakia, 949 88
Novartis Investigative Site
Nove Zamky, Slovakia, 940 01
Novartis Investigative Site
Nove Zamky, Slovakia, 94002
Novartis Investigative Site
Piestany, Slovakia, 921 01
Novartis Investigative Site
Presov, Slovakia, 080 01
Novartis Investigative Site
Svidnik, Slovakia, 089 01
Novartis Investigative Site
Trebisov, Slovakia, 075 01
Novartis Investigative Site
Zilina, Slovakia, 012 07
Slovenia
Novartis Investigative Site
Golnik, Slovenia, 4204
Novartis Investigative Site
Ljubljana, Slovenia, 1000
South Africa
Novartis Investigative Site
Mthatha, Eastern Cape, South Africa
Novartis Investigative Site
Bloemfontein, Free State, South Africa, 9301
Novartis Investigative Site
Soweto, Gauteng, South Africa, 2013
Novartis Investigative Site
Durban, Kwa-Zulu Natal, South Africa, 4052
Novartis Investigative Site
Paarl, Western Cape, South Africa, 7626
Novartis Investigative Site
Alberton, South Africa, 1449
Novartis Investigative Site
Bloemfontein, South Africa, 9301
Novartis Investigative Site
Cape Town, South Africa, 7505
Novartis Investigative Site
Cape Town, South Africa, 7531
Novartis Investigative Site
Cape Town, South Africa, 7925
Novartis Investigative Site
Durban, South Africa, 4001
Novartis Investigative Site
Johannesburg, South Africa, 2193
Novartis Investigative Site
Pretoria, South Africa, 0121
Novartis Investigative Site
Tongaat, South Africa, 3300
Novartis Investigative Site
Western Cape, South Africa, 7130
Novartis Investigative Site
Worcester, South Africa, 6850
Spain
Novartis Investigative Site
Almeria, Andalucia, Spain, 04120
Novartis Investigative Site
Cordoba, Andalucia, Spain, 14004
Novartis Investigative Site
Malaga, Andalucia, Spain, 29010
Novartis Investigative Site
Marbella, Andalucia, Spain, 29600
Novartis Investigative Site
Sanlúcar de Barrameda, Andalucia, Spain, 11540
Novartis Investigative Site
Sevilla, Andalucia, Spain, 41013
Novartis Investigative Site
Sevilla, Andalucia, Spain, 41014
Novartis Investigative Site
Oviedo, Asturias, Spain, 33011
Novartis Investigative Site
Sant Joan Despi, Barcelona, Spain, 08970
Novartis Investigative Site
Villamartin, Cadiz, Spain, 11650
Novartis Investigative Site
Santander, Cantabria, Spain, 39008
Novartis Investigative Site
Aranda de Duero, Castilla y Leon, Spain, 09400
Novartis Investigative Site
Leon, Castilla y Leon, Spain, 24071
Novartis Investigative Site
Lerida, Cataluna, Spain, 25198
Novartis Investigative Site
Badalona, Catalunya, Spain, 08916
Novartis Investigative Site
Barcelona, Catalunya, Spain, 08003
Novartis Investigative Site
Alzira, Comunidad Valenciana, Spain, 46600
Novartis Investigative Site
Valencia, Comunidad Valenciana, Spain, 46010
Novartis Investigative Site
Valencia, Comunidad Valenciana, Spain, 46014
Novartis Investigative Site
Valencia, Comunidad Valenciana, Spain, 46026
Novartis Investigative Site
Merida, Extremadura, Spain, 06800
Novartis Investigative Site
A Coruna, Galicia, Spain, 15006
Novartis Investigative Site
Santiago de Compostela, Galicia, Spain, 15706
Novartis Investigative Site
Olot, Girona, Spain, 17800
Novartis Investigative Site
Majadahonda, Madrid, Spain, 28222
Novartis Investigative Site
Mostoles, Madrid, Spain, 28935
Novartis Investigative Site
El Palmar, Murcia, Spain, 30120
Novartis Investigative Site
Ciudad Real, Spain, 13005
Novartis Investigative Site
Madrid, Spain, 28007
Novartis Investigative Site
Madrid, Spain, 28034
Novartis Investigative Site
Madrid, Spain, 28040
Novartis Investigative Site
Madrid, Spain, 28046
Sweden
Novartis Investigative Site
Danderyd, Sweden, 182 88
Novartis Investigative Site
Falun, Sweden, 791 82
Novartis Investigative Site
Goteborg, Sweden, 413 45
Novartis Investigative Site
Karlstad, Sweden, 652 30
Novartis Investigative Site
Linkoping, Sweden, 581 85
Novartis Investigative Site
Lund, Sweden, 222 21
Novartis Investigative Site
Stockholm, Sweden, 17176
Novartis Investigative Site
Vasteras, Sweden, s-721 89
Novartis Investigative Site
Örebro, Sweden, 701 85
Switzerland
Novartis Investigative Site
Basel, Switzerland, 4031
Novartis Investigative Site
Bern, Switzerland, 3010
Novartis Investigative Site
Biel, Switzerland, 2500
Novartis Investigative Site
Lausanne, Switzerland, 1011
Novartis Investigative Site
Lugano, Switzerland, 6903
Novartis Investigative Site
Zurich, Switzerland, 8091
Taiwan
Novartis Investigative Site
Yongkang, Tainan, Taiwan, 71004
Novartis Investigative Site
Tainan, Taiwan ROC, Taiwan, 70421
Novartis Investigative Site
Changhua, Taiwan, 50006
Novartis Investigative Site
Kaohsiung, Taiwan, 807
Novartis Investigative Site
Taichung, Taiwan, 40447
Novartis Investigative Site
Taipei County, Taiwan, 22060
Novartis Investigative Site
Taipei, Taiwan, 10002
Novartis Investigative Site
Taipei, Taiwan, 112
Novartis Investigative Site
Yilan, Taiwan, 26058
Turkey
Novartis Investigative Site
Ankara, Turkey, 06100
Novartis Investigative Site
Balcova / Izmir, Turkey, 35340
Novartis Investigative Site
Fatih / Istanbul, Turkey, 34098
Novartis Investigative Site
Haydarpasa/Istanbul, Turkey, 34668
Novartis Investigative Site
Istanbul, Turkey, 34304
Novartis Investigative Site
Izmir, Turkey, 35040
Novartis Investigative Site
Kocaeli, Turkey, 41380
Novartis Investigative Site
Pendik / Istanbul, Turkey, 34899
Novartis Investigative Site
Sivas, Turkey, 58140
United Kingdom
Novartis Investigative Site
High Wycombe, Buckinghamshire, United Kingdom, HP11 2TT
Novartis Investigative Site
Stockton on Tees, Cleveland, United Kingdom, TS19 8PE
Novartis Investigative Site
Darlington, Co Durham, United Kingdom, DL3 8SQ
Novartis Investigative Site
Durham, County Durham, United Kingdom, DH1 5TW
Novartis Investigative Site
Torquay, Devon, United Kingdom, TQ2 7AA
Novartis Investigative Site
Dorchester, Dorset, United Kingdom, DT1 2JY
Novartis Investigative Site
Peterborough, GBR, United Kingdom, PE3 6DA
Novartis Investigative Site
Basingstoke, Hampshire, United Kingdom, RG24 9NA
Novartis Investigative Site
Portsmouth, Hampshire, United Kingdom, PO6 3LY
Novartis Investigative Site
Oldham, Lancashire, United Kingdom, OL1 2JH
Novartis Investigative Site
Harrow, Middlesex, United Kingdom, HA1 3UJ
Novartis Investigative Site
Whitby, North Yorkshire, United Kingdom, Y021 1SD
Novartis Investigative Site
Portadown, Nothern Ireland, United Kingdom, BT63 5QQ
Novartis Investigative Site
Wansford, Peterborough, United Kingdom, PE8 6PL
Novartis Investigative Site
Glasgow, Scotland, United Kingdom, G12 8TA
Novartis Investigative Site
Taunton, Somerset, United Kingdom, TA1 5DA
Novartis Investigative Site
Gateshead, Tyne and Wear, United Kingdom, NE9 6SX
Novartis Investigative Site
South Shields, Tyne and Wear, United Kingdom, NE34 0PL
Novartis Investigative Site
Clydebank, West Dumbartonshire, United Kingdom, G81 4HX
Novartis Investigative Site
Bath, United Kingdom, BA2 4BY
Novartis Investigative Site
Cheshire, United Kingdom, CW1 4QJ
Novartis Investigative Site
Coventry, United Kingdom, CV2 2DX
Novartis Investigative Site
Dundee, United Kingdom, DD1 9SY
Novartis Investigative Site
Glasgow, United Kingdom, G20 0XA
Novartis Investigative Site
Hull, United Kingdom, HU16 5JQ
Novartis Investigative Site
Leicester, United Kingdom, LE3 9QP
Novartis Investigative Site
London, United Kingdom, SE5 9RS
Novartis Investigative Site
London, United Kingdom, SW 6NP
Novartis Investigative Site
Newport, United Kingdom, NP20 2UB
Novartis Investigative Site
Nottingham, United Kingdom, NG5 1PB
Novartis Investigative Site
Sheffield, United Kingdom, S5 7AU
Novartis Investigative Site
Swindon, United Kingdom, SN3 6BB
Novartis Investigative Site
Wiltshire, United Kingdom, SN15 2SB
Novartis Investigative Site
Wrexham, United Kingdom, LL13 7TD
Sponsors and Collaborators
Novartis Pharmaceuticals
Investigators
Study Director: Novartis Pharmaceuticals Novartis Pharmaceuticals
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Novartis Pharmaceuticals
ClinicalTrials.gov Identifier: NCT01920711     History of Changes
Other Study ID Numbers: CLCZ696D2301
2013-001747-31 ( EudraCT Number )
Study First Received: August 8, 2013
Last Updated: May 12, 2017
Individual Participant Data  
Plan to Share IPD: Undecided
Plan Description:

Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations.

This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com


Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Novartis ( Novartis Pharmaceuticals ):
Heart failure
preserved ejection fraction
diastolic heart failure

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases
Valsartan
LCZ 696
Antihypertensive Agents
Angiotensin II Type 1 Receptor Blockers
Angiotensin Receptor Antagonists
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on June 26, 2017