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Study Of Diabetic Nephropathy With Atrasentan (SONAR)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01858532
Recruitment Status : Terminated (Strategic considerations)
First Posted : May 21, 2013
Last Update Posted : April 26, 2018
Sponsor:
Information provided by (Responsible Party):
AbbVie

Brief Summary:
This study is being conducted to evaluate the effects of Atrasentan on Renal Outcomes in Subjects with Type 2 Diabetes and Nephropathy.

Condition or disease Intervention/treatment Phase
Diabetic Nephropathy Drug: Atrasentan Drug: Placebo Phase 3

Detailed Description:
The study objective is to evaluate the effect of atrasentan compared with placebo on time to doubling of serum creatinine or the onset of end stage renal disease (ESRD) in subjects with type 2 diabetes and nephropathy who are treated with the maximum tolerated labeled daily dose (MTLDD) of a Renin Angiotensin System (RAS) inhibitor. In addition, the study will assess the effects of atrasentan compared with placebo on cardiovascular morbidity and mortality, urine albumin excretion, changes in estimated glomerular filtration rate (eGFR), as well as on the impact on quality of life in subjects with type 2 diabetes and nephropathy.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 5112 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized, Multicountry, Multicenter, Double-Blind, Parallel, Placebo-Controlled Study of the Effects of Atrasentan on Renal Outcomes in Subjects With Type 2 Diabetes and Nephropathy SONAR: Study Of Diabetic Nephropathy With Atrasentan
Actual Study Start Date : May 17, 2013
Actual Primary Completion Date : March 29, 2018
Actual Study Completion Date : March 29, 2018

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Active Comparator: Atrasentan
Subjects randomized to the atrasentan arm will receive active drug, atrasentan.
Drug: Atrasentan
Oral daily low dose for 48 months.
Placebo Comparator: Placebo
Subjects randomized to the placebo arm will receive placebo.
Drug: Placebo
Oral daily dosing for 48 months.



Primary Outcome Measures :
  1. Time to the first occurrence of a component of the composite renal endpoint. [ Time Frame: Approximately 48 months. ]
    Time to the first occurrence of a component of the composite renal endpoint: doubling of serum creatinine (confirmed by a 30-day serum creatinine) or the onset of end stage renal disease (estimated glomerular filtration rate (eGFR) less than 15 ml/min/1.73 m2 confirmed by a 90-day eGFR, receiving chronic dialysis, renal transplantation or renal death).


Secondary Outcome Measures :
  1. Time to first occurrence of a component of composite renal endpoint: confirmed doubling of serum creatinine or the onset of end stage renal disease for all randomized subjects (pooled). [ Time Frame: Approximately 48 months. ]
  2. Time to a 50% estimated glomerular filtration rate reduction. [ Time Frame: Approximately 48 months. ]
  3. Time to the cardiovascular composite endpoint: cardiovascular death, nonfatal myocardial infarction and nonfatal stroke. [ Time Frame: Approximately 48 months. ]
  4. Time to cardio-renal composite endpoint: confirmed doubling of serum creatinine, end stage renal disease, cardiovascular death, nonfatal myocardial infarction, nonfatal stroke. [ Time Frame: Approximately 48 months. ]


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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Subject has type 2 diabetes (including patients with latent autoimmune diabetes or insulin-treated patients without a history of diabetic ketoacidosis who also have a negative anti-glutamic acid decarboxylase test AND an elevated post-prandial serum C-peptide level) and has been treated with at least one anti-hyperglycemic medication and ACEi/or ARB (RAS inhibitor) for at least 4 weeks prior to the Screening S2 visit.
  • For entry into the Run-In Period the subject must satisfy the following criteria based on the Screening laboratory values:

    • Estimated glomerular filtration rate (eGFR) 25 to 75 mL/min/1.73 m2 [until the eGFR cap on subjects (approximately 300) with a baseline of > 60 mL/min/1.73 m2 is reached] and a urine albumin creatinine ratio (UACR) greater than or equal to 300 and less than 5,000 mg/g (greater than or equal to 34 mg/mmol and less than 565 mg/mmol);
    • Serum albumin greater than or equal to 2.5 g/dL (25 g/L);
    • Brain natriuretic peptide (BNP) less than or equal to 200 pg/mL (200 ng/L);
    • Systolic blood pressure (SBP) greater than or equal to 110 and less than or equal to 180 mmHg;
    • Serum Potassium greater than or equal to 3.5 mEq/L (3.5 mmol/L) and less than or equal to 6.0 mEq/L (6.0 mmol/L);
    • Subjects on a maximum tolerated labeled daily dose (MTLDD) of a RAS inhibitor for greater than or equal to 4 weeks and on a diuretic at the time of screening and who satisfy the above criteria may proceed to the last visit in Run-In Period (R6);
    • Subjects already on a MTLDD of a RAS inhibitor for greater than or equal to 4 weeks and not on a diuretic (unless medically contraindicated) at the time of Screening will start with a diuretic and proceed to Run-In for at least 2 weeks.
  • For entry into the Enrichment Period the subject must satisfy the following criteria based on the last visit of the Run-In Period:

    • RAS inhibitor at the MTLDD for the previous 4 weeks with no adjustments of the dose;
    • Subjects that were on a MTLDD RAS inhibitor and not on a diuretic (unless medically contraindicated) at the time of Screening must have been in Run-In for at least 2 weeks.
  • For entry into the Double-Blind Treatment Period, the subject must satisfy the following criteria based on the last visit of the Enrichment Period:

    • RAS inhibitor at the MTLDD for the previous 6 weeks during the Enrichment Period with no adjustments of the dose;
    • Diuretic at any dose unless medically contraindicated or clinically intolerable in the investigator's judgement (i.e., hypotension or hypokalemia);
    • Subject must not have a weight change greater than or equal to 3 kg from the beginning of Enrichment to the end of the Enrichment Period and absolute serum BNP greater than or equal to 300 pg/mL (300 ng/L) at the last Enrichment visit;
    • Subject must not have an increase in serum creatinine greater than 0.5 mg/dL and greater than 20% increase from the beginning of Enrichment to the end of the Enrichment Period.

Exclusion Criteria:

  • Subject has a history of severe peripheral edema or facial edema requiring diuretics unrelated to trauma or a history of myxedema in the prior 4 weeks to the initial Screening S1 visit.
  • Subject has a history of pulmonary hypertension, pulmonary fibrosis or any lung diseases requiring oxygen therapy (e.g., chronic obstructive pulmonary disease, emphysema).
  • Subject has a documented diagnosis of heart failure, previous hospitalization for heart failure or current or constellation of symptoms (dyspnea on exertion, pedal edema, orthopnea, paroxysmal nocturnal dyspnea) felt to be compatible with heart failure, that was not explained by other causes, and for which there was a change in medication or other management directed at heart failure.
  • Subject has known non-diabetic kidney disease (other than kidney stones).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01858532


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Locations
United States, Alabama
Nephrology Associates P.C.
Birmingham, Alabama, United States, 35209
University of Alabama
Birmingham, Alabama, United States, 35233
Nephrology Consultants, LLC
Huntsville, Alabama, United States, 35805
Alabama Medical Group, PC
Mobile, Alabama, United States, 36608
United States, Arizona
AKDHC Medical Research Service
Peoria, Arizona, United States, 85381
Arizona Kidney Disease and Hyp
Phoenix, Arizona, United States, 85012
Phoenix VA Healthcare
Phoenix, Arizona, United States, 85012
AKDHC Medical Research Service
Prescott, Arizona, United States, 86301
AKDHC Med Res Services LLC
Tucson, Arizona, United States, 85712
University Arizona Cancer Ctr
Tucson, Arizona, United States, 85719-1478
Veterans Affairs (VA) Health Care System - Tucson
Tucson, Arizona, United States, 85723-0001
United States, Arkansas
B.G. Clinical Research Center, LLC
Little Rock, Arkansas, United States, 72205
United States, California
Sakhrani, Alhambra, CA.
Alhambra, California, United States, 91801
North America Research Institu
Azusa, California, United States, 91702
Natl Inst Clinical Research
Bakersfield, California, United States, 93309
California Institute Renal Res
Chula Vista, California, United States, 91910
San Diego Coastal Endocrinolog
Chula Vista, California, United States, 91911
Janett DelaCruz FNP, a Professional Nursing Corporation.
Downey, California, United States, 90240
Rancho Los Amigos National Reh
Downey, California, United States, 90242
St. Jude Hospital
Fullerton, California, United States, 92835
California Renal Res Network
Glendale, California, United States, 91204
High Desert Nephrology Associa
Lancaster, California, United States, 93534
VA Loma Linda
Loma Linda, California, United States, 92354
VA Long Beach Healthcare System
Long Beach, California, United States, 90822
Academic Medical Research Inst
Los Angeles, California, United States, 90022
Axis Clinical Trials
Los Angeles, California, United States, 90036
National Research Institute
Los Angeles, California, United States, 90059
University of California, Los Angeles
Los Angeles, California, United States, 90095
Facey Medical Foundation
Los Angeles, California, United States, 91345
Providence Clinical Research
North Hollywood, California, United States, 91606
Lucita M. Cruz MD
Norwalk, California, United States, 90650
Diabetes Associates Medical Gr
Orange, California, United States, 92868
Desert Medical Group, Inc.
Palm Springs, California, United States, 92262
Mohammed Ismail, MD, Inc.
Paramount, California, United States, 90723
Sierra View Nephrology Inc
Porterville, California, United States, 93257
Inland Empire Liver Foundation
Rialto, California, United States, 92377
APEX Research of Riverside
Riverside, California, United States, 92505
Capital Nephrology Medical Gro
Sacramento, California, United States, 95825
Central Coast Nephrology
Salinas, California, United States, 93901
California Institute Renal Res
San Diego, California, United States, 92123
VA San Diego Healthcare System
San Diego, California, United States, 92161
Univ California, San Francisco
San Francisco, California, United States, 94143-2204
Sansum Clinic
Santa Barbara, California, United States, 93105
United States, Colorado
Denver Nephrologists, PC dba C
Denver, Colorado, United States, 80218
United States, Connecticut
Yale University
New Haven, Connecticut, United States, 06510
Stamford Nephrology
Stamford, Connecticut, United States, 06902
United States, Delaware
Christiana Care Health Service
Newark, Delaware, United States, 19713
United States, District of Columbia
George Washington Univ Med
Washington, District of Columbia, United States, 20037
United States, Florida
Innovative Med Res of South FL
Aventura, Florida, United States, 33180
ZASA Clinical Research
Boynton Beach, Florida, United States, 33472
Meridien Research Group
Bradenton, Florida, United States, 34208
Clinical Research of Brandon
Brandon, Florida, United States, 33511
South Florida Nephrology Group
Coral Springs, Florida, United States, 33071
West Broward Research Institut
Fort Lauderdale, Florida, United States, 33313
Lee County Internal Medicine A
Fort Myers, Florida, United States, 33912
University of Florida
Gainesville, Florida, United States, 32610
FPA Fam Hlth Care Clin Studies
Kissimmee, Florida, United States, 34741
San Marcus Research Clinic, In
Miami, Florida, United States, 33015
Premier Clinical Research Inst
Miami, Florida, United States, 33122
Premier Research Associate Inc
Miami, Florida, United States, 33165
Compass Research LLC
Orlando, Florida, United States, 32806
Peninsula Research, Inc.
Ormond Beach, Florida, United States, 32174
Nephrology Associates
Panama City, Florida, United States, 32401
Pines Care Research Center, In
Pembroke Pines, Florida, United States, 33029
Hanson Clinical Research Ctr
Port Charlotte, Florida, United States, 33952
Central Florida Internists
Saint Cloud, Florida, United States, 34769
Prof Health Care of Pinellas
Saint Petersburg, Florida, United States, 33713-8900
James A. Haley Veteran's Hosp
Tampa, Florida, United States, 33612
Metabolic Research Inst
West Palm Beach, Florida, United States, 33401
United States, Georgia
Emory University Hospital
Atlanta, Georgia, United States, 30322
Georgia Regents University
Augusta, Georgia, United States, 30912
Atlanta Nephro Referral Center
Decatur, Georgia, United States, 30030
Emory Univ & Atlanta VAMC
Decatur, Georgia, United States, 30033
Kaiser FDN Health Plan of GA
Duluth, Georgia, United States, 30096
Alta Pharmaceutical Research
Dunwoody, Georgia, United States, 30338
Gwinnett Biomedical Research
Lawrenceville, Georgia, United States, 30046
Herman Clinical Research, LLC
Suwanee, Georgia, United States, 30024-1059
United States, Hawaii
University of Hawaii
Honolulu, Hawaii, United States, 96813
East-West Medical Research Institute
Honolulu, Hawaii, United States, 96814
United States, Illinois
Jesse Brown VA Medical Center
Chicago, Illinois, United States, 60612
Apex Medical Research, Inc.
Chicago, Illinois, United States, 60616
University of Chicago
Chicago, Illinois, United States, 60637-1443
NorthShore Univ HealthSystem
Evanston, Illinois, United States, 60201
Kidney Care Center
Joliet, Illinois, United States, 60435
United States, Indiana
Community Clinical Res Ctr
Anderson, Indiana, United States, 46011
Nephrology Ass. of N. Indiana
Fort Wayne, Indiana, United States, 46804
United States, Iowa
IA Diabetes & Endo Res Ctr
Des Moines, Iowa, United States, 50314
University of Iowa Hospitals
Iowa City, Iowa, United States, 52242
United States, Kansas
My Kidney Center, LLC
Manhattan, Kansas, United States, 66502
United States, Kentucky
University of Louisville
Louisville, Kentucky, United States, 40202
Four Rivers Clinical Research
Paducah, Kentucky, United States, 42003
United States, Louisiana
Crescent City Clinical Res Ctr
Metairie, Louisiana, United States, 70006
Tulane Univ
New Orleans, Louisiana, United States, 70112
Internal Medicine Specialists
New Orleans, Louisiana, United States, 70115
Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121
Green Clinic LLC
Ruston, Louisiana, United States, 71270
Louisiana State Univ HSC
Shreveport, Louisiana, United States, 71130
United States, Maine
Maine Research Associates
Auburn, Maine, United States, 04210
United States, Maryland
Anne Arundel Medical Center
Annapolis, Maryland, United States, 21401
Model Clinical Research
Baltimore, Maryland, United States, 21204
Washington Nephrology Assoc
Bethesda, Maryland, United States, 20814
Adventist Medical Group
Camp Springs, Maryland, United States, 20746
Biolab Research, LLC
Rockville, Maryland, United States, 20852
United States, Massachusetts
Pentucket Medical Assoc
Haverhill, Massachusetts, United States, 01830
ActivMed Practices and Researc
Methuen, Massachusetts, United States, 01844
South Shore Nephrology, P.C.
Plymouth, Massachusetts, United States, 02360
Renal and Transplant Associate
Springfield, Massachusetts, United States, 01107
United States, Michigan
Renaissance Renal Research
Detroit, Michigan, United States, 48224
Hurley Medical Center
Flint, Michigan, United States, 48503
Apex Medical Research, MI,Inc.
Flint, Michigan, United States, 48504
Remedica LLC
Rochester Hills, Michigan, United States, 48307
United States, Mississippi
SouthWest Mississippi Nephrolo
Brookhaven, Mississippi, United States, 39601
Univ of Mississippi Med Ctr,US
Jackson, Mississippi, United States, 39216-4643
United States, Missouri
Harry S. Truman Mem Veter Hosp
Columbia, Missouri, United States, 65201
Farmington Research LLC
Farmington, Missouri, United States, 63640
Clinical Research Consultants,
Kansas City, Missouri, United States, 64111-5941
Kansas City VA Medical Center
Kansas City, Missouri, United States, 64128
VA Saint Louis Health Care
Saint Louis, Missouri, United States, 63106
United States, Nebraska
Alegent Creighton Health
Omaha, Nebraska, United States, 68124
Creighton Univ Med Ctr
Omaha, Nebraska, United States, 68131
United States, Nevada
Palm Research Center, Inc.
Las Vegas, Nevada, United States, 89103
NV Kidney Dis Hyper Ctr NKDHC
Las Vegas, Nevada, United States, 89115
Sierra Nevada Nephro Consult
Reno, Nevada, United States, 89511
United States, New Hampshire
Seacoast Kidney and Hypertensi
Portsmouth, New Hampshire, United States, 03801
United States, New Jersey
Cooper Nephrology
Camden, New Jersey, United States, 08103
Hypertension and Nephrology
Eatontown, New Jersey, United States, 07724
Jersey Shore University Medical Center
Neptune, New Jersey, United States, 07753-4859
United States, New Mexico
University of New Mexico
Albuquerque, New Mexico, United States, 87102
Renal Medicine Associates
Albuquerque, New Mexico, United States, 87109
United States, New York
Albany Medical College
Albany, New York, United States, 12208
Ladan Golestaneh, MD, MS
Bronx, New York, United States, 10467
SUNY Downstate Medical Center
Brooklyn, New York, United States, 11203
Bentsianov, Brooklyn, NY
Brooklyn, New York, United States, 11224
Israel, MD, Brooklyn, NY
Brooklyn, New York, United States, 11229
Erie County Medical Center
Buffalo, New York, United States, 14215
North Shore Diabetes
New Hyde Park, New York, United States, 11042
DeFabritus, New York, NY
New York, New York, United States, 10001
VA NY Harbor Healthcare System
New York, New York, United States, 10010
NYU Langone Medical Center
New York, New York, United States, 10016-6402
NY Clinical Trials
New York, New York, United States, 10018
Kaufman, New York, NY
New York, New York, United States, 10021
Rogosin Institute
New York, New York, United States, 10021
Renal Research Institute
New York, New York, United States, 10128
Hypertension & Renal Research
Orchard Park, New York, United States, 14127
Clinical Research Dev Assoc
Rosedale, New York, United States, 11422
United States, North Carolina
Mountain Kidney Research
Asheville, North Carolina, United States, 28801
Metrolina Nephrology Assoc. PA
Charlotte, North Carolina, United States, 28207
Sensenbrenner Primary Care
Charlotte, North Carolina, United States, 28277
Eastern Nephrology Associates
Greenville, North Carolina, United States, 27834
East Carolina University
Greenville, North Carolina, United States, 27858
Eastern Nephrology Associates
Kinston, North Carolina, United States, 28504
Carteret Medical Group - Morehead City
Morehead City, North Carolina, United States, 28557-4346
Eastern Nephrology Associates
New Bern, North Carolina, United States, 28562
Boice-Willis Clinic, P.A.
Rocky Mount, North Carolina, United States, 27804
W.G. (Bill) Hefner VAMC
Salisbury, North Carolina, United States, 28144
Brookview Hills Research Assoc
Winston-Salem, North Carolina, United States, 27103
United States, Ohio
VAMC Cincinnati
Cincinnati, Ohio, United States, 45220
University of Cincinnati
Cincinnati, Ohio, United States, 45267-2827
MetroHealth Medical Center
Cleveland, Ohio, United States, 44109
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Endocrinology Associates, Inc.
Columbus, Ohio, United States, 43201
Clinical Research Solutions
Middleburg Heights, Ohio, United States, 44130-3639
United States, Oklahoma
Harold Hamm Diabetes Center
Oklahoma City, Oklahoma, United States, 73104
United States, Oregon
Oregon Health and Science University
Portland, Oregon, United States, 97239-3098
United States, Pennsylvania
Northeast Clin Res Bethlehem
Bethlehem, Pennsylvania, United States, 18017
Penn State University and Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107-4414
Drexel Univ College of Med
Philadelphia, Pennsylvania, United States, 19129
Temple University Hospital
Philadelphia, Pennsylvania, United States, 19140
Philadelphia Health Associates
Philadelphia, Pennsylvania, United States, 19146
VA Pittsburgh HealthcareSystem
Pittsburgh, Pennsylvania, United States, 15240
Pref Primary Care Phys Inc
Pittsburgh, Pennsylvania, United States, 15243
United States, Rhode Island
Rhode Island Hospital
Providence, Rhode Island, United States, 02905
United States, South Carolina
Columbia Nephrology Associates
Columbia, South Carolina, United States, 29203
WJB Dorn Va Medical Center
Columbia, South Carolina, United States, 29209
Greenville Health System - Int'l Dr
Greenville, South Carolina, United States, 29615
Carolina Health Specialists
Myrtle Beach, South Carolina, United States, 29572
SC Nephrology & Hypertension
Orangeburg, South Carolina, United States, 29118
United States, Tennessee
Southeast Renal Research Inst
Chattanooga, Tennessee, United States, 37404
Advanced Kidney Specialists Pc
Jackson, Tennessee, United States, 38305
Knoxville Kidney Center, PLLC
Knoxville, Tennessee, United States, 37923
Univ TN Health Sciences Ctr
Memphis, Tennessee, United States, 38103
United States, Texas
DCT - MHR, LLC dba Discovery Clinical Trials
Arlington, Texas, United States, 76014
Brusco, Corpus Christi, TX
Corpus Christi, Texas, United States, 78414
Houston Nephrology Group
Cypress, Texas, United States, 77429
Texas Health Physicians Group
Dallas, Texas, United States, 75218
North TX Endocrine Ctr
Dallas, Texas, United States, 75231
Alvarado, Fort Worth, TX
Fort Worth, Texas, United States, 76104
Diagnostic Clinic Of Houston
Houston, Texas, United States, 77004
Endocrine Associates
Houston, Texas, United States, 77004
Kidney and Hypertension Care
Houston, Texas, United States, 77004
JM Research
Houston, Texas, United States, 77011
PrimeCare Medical Group
Houston, Texas, United States, 77024
Angiocardiac Care of Texas, PA
Houston, Texas, United States, 77025
Southwest Houston Nephrology
Houston, Texas, United States, 77074
TX Tech Univ Health Science
Lubbock, Texas, United States, 79415
East Texas Nephrology Assoc
Lufkin, Texas, United States, 75904
Texas Institute for Kidney & E
Lufkin, Texas, United States, 75904
DCT - McAllen Primary Care Res
McAllen, Texas, United States, 78503
South Texas Kidney Specialists
McAllen, Texas, United States, 78503
Sunbeam Clinical Research
McKinney, Texas, United States, 75069
Clinical Advancement Center
San Antonio, Texas, United States, 78215
Briggs Clinical Research, LLC
San Antonio, Texas, United States, 78224
Audie L. Murphy VA Med. Center
San Antonio, Texas, United States, 78229
San Antonio Kidney Disease Ctr
San Antonio, Texas, United States, 78229
Univ Texas HSC San Antonio
San Antonio, Texas, United States, 78229
Kidney Innovations
Weslaco, Texas, United States, 78596
United States, Utah
Advanced Research Institute
Ogden, Utah, United States, 84405-6779
Southern Utah Kidney and Hyper
Saint George, Utah, United States, 84790
University of Utah
Salt Lake City, Utah, United States, 84112-5500
United States, Vermont
University of Vermont Medical Center
Burlington, Vermont, United States, 05401-1473
VA Medical Center
White River Junction, Vermont, United States, 05009
United States, Virginia
Nephrology Assoc Northern VA
Fairfax, Virginia, United States, 22033
McGuire VA Medical Center
Richmond, Virginia, United States, 23249
Salem VA Medical Center
Salem, Virginia, United States, 24153
United States, Washington
Northside Internal Medicine DE
Spokane, Washington, United States, 99208
MultiCare Inst for Research & Innovation
Tacoma, Washington, United States, 98405
United States, West Virginia
West Virginia Univ School Med
Morgantown, West Virginia, United States, 26506
United States, Wisconsin
Marshfield Clinic - Marshfield
Marshfield, Wisconsin, United States, 54449
Zablocki VA Medical Center
Milwaukee, Wisconsin, United States, 53295
Argentina
Hospital Italiano
Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina, C1181ACH
Instituto de Investigaciones
Bahia Blanca, Argentina, 8000
Cons Asoc Endo/Inv Clin Aplica
Buenos Aires, Argentina, 1425
Inst de Inv Med Alfredo Lanari
Buenos Aires, Argentina, 1427
CEMIC
Buenos Aires, Argentina, 1431
Inst Latinam Investig. Medicas
Cordoba, Argentina, 5000
Fundacion J. Robert Cade
Cordoba, Argentina, 5002
Hosp Privado Ctr Med Cordoba
Cordoba, Argentina, 5016
Blossom DMO
Cordoba, Argentina, 5019
Instit Cardio Juana F Cabral
Corrientes, Argentina, 3400
Centro de Salud Renal Junin SR
Junin, Argentina, 6000
Ctr Invest Medic Mar del Plata
Mar Del Plata, Argentina, 7600
Instituto de Nefrologia Pergam
Pergamino, Argentina, 2700
Investigaciones Clin Tucuman
San Miguel de Tucuman, Argentina, 4000
CEREHA
Sarandi, Argentina, 1872
Australia, New South Wales
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, 2050
Concord Repatriation & Gen Hos
Concord, New South Wales, Australia, 2139
Renal Research
Gosford, New South Wales, Australia, 2250
Liverpool Hospital
Liverpool, New South Wales, Australia, 2170
John Hunter Hospital
Newcastle, New South Wales, Australia, 2305
The Prince of Wales Hospital
Randwick, New South Wales, Australia, 2031
Royal North Shore Hospital
Saint Leonards, New South Wales, Australia, 2065
Australia, Queensland
Nambour General Hospital
Nambour, Queensland, Australia, 4560
Australia, South Australia
Southern Adelaide
Daw Park, South Australia, Australia, 5041
Australia, Tasmania
Launceston General Hospital
Launceston, Tasmania, Australia, 7250
Australia, Victoria
St. Vincents Hosp Melbourne
Fitzroy, Victoria, Australia, 3065
Box Hill Hospital
Melbourne, Victoria, Australia, 3128
Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Australia, Western Australia
Fremantle Hospital
Fremantle, Western Australia, Australia, 6160
Sir Charles Gairdner Hospital
Nedlands, Western Australia, Australia, 6009
Austria
AKH Wien
Vienna, Wein, Austria, 1090
Medical University Innsbruck
Innsbruck, Austria, 6020
Krankenhaus Hietzing
Vienna, Austria, 1130
Belgium
CUB Hospital Erasme
Brussels, Bruxelles-Capitale, Belgium, 1070
Cliniques Universitaires Saint Luc
Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium, 1200
Onze Lieve Vrouw Hospital
Aalst, Belgium, 9300
Imelda Ziekenhuis
Bonheiden, Belgium, 2820
UZ Antwerp
Edegem, Belgium, 2650
UZ Leuven
Leuven, Belgium, 3000
CHR de la Citadelle
Liege, Belgium, 4000
Brazil
Clinica Senhor do Bonfim
Feira de Santana, Bahia, Brazil, 44001-584
Clinica Senhor do Bonfim
Salvador, Bahia, Brazil, 40415-065
Centro de Estudos
Fortaleza, Ceara, Brazil, 60115-282
Centro de Pesquisa Clinica do
Brasilia, Distrito Federal, Brazil, 71625-009
Hospital Geral de Goiania
Goiania, Goias, Brazil, 74043-011
Hospital SOCOR
Belo Horizonte, Minas Gerais, Brazil, 30430-260
Cline Research Center
Curitiba, Parana, Brazil, 80030
Hospital Universitario Cajuru
Curitiba, Parana, Brazil, 80215-901
Instituto Scribner de Pesquisa
Curitiba, Parana, Brazil, 80240-220
Hosp Univ Joao De Barros Barre
Belem, Para, Brazil, 66073-000
Irmandade da Santa Casa de
Porto Alegre, Rio Grande Do Sul, Brazil, 90020-090
Centro de Pesquisa em Diabetes
Porto Alegre, Rio Grande Do Sul, Brazil, 90035-170
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903
Hospital Sao Lucas da PUCRS
Porto Alegre, Rio Grande Do Sul, Brazil, 90610-000
Fundacao Pro Rim
Joinville, Santa Catarina, Brazil, 89227-680
Hospital das Clinicas da Faculdade de Medicina da USP - HCFMUSP
São Paulo, Sao Paulo, Brazil, 05403-000
IPEC - Instituto de Pesquisa
Sao Paulo, Brazil, 01223-001
CPQuali Pesquisa Clinica Ltda
Sao Paulo, Brazil, 01228-000
Centro de Pesquisas Clinicas
Sao Paulo, Brazil, 01244-030
Clinica de Endocrinologia
Sao Paulo, Brazil, 01323-001
Hospital Beneficencia Portugue
Sao Paulo, Brazil, 01323-001
Instituto Dante Pazzanese Card
Sao Paulo, Brazil, 04012-909
UNIFESP/Unidade de Atendimento Pesquisa Clínica 1
Sao Paulo, Brazil, 04037-003
Hospital do Rim
Sao Paulo, Brazil, 04038-002
Canada, Alberta
Zeidler Ledcor Centre
Edmonton, Alberta, Canada, T6G 2X8
The Bailey Clinic
Red Deer, Alberta, Canada, T4N 3Z2
Canada, British Columbia
St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Canada, Ontario
JBN Medical Diagnostic Servic
Burlington, Ontario, Canada, L7M 4Y1
Co-Medica Research Network
Courtice, Ontario, Canada, L1E 3C3
St. Joseph's Healthcare
Hamilton, Ontario, Canada, L8N 4A6
OTT Healthcare Inc.
Scarborough, Ontario, Canada, M1H 3G4
Medicor Research Inc.
Sudbury, Ontario, Canada, P3A 1W8
Humber River Hospital
Toronto, Ontario, Canada, M3M 0B2
Toronto East General Med Ctr
Toronto, Ontario, Canada, M4C 3E7
Sunnybrook Health Sciences Ctr
Toronto, Ontario, Canada, M4N 3M5
LMC Diabetes and Endocrinology
Toronto, Ontario, Canada, M9R 4E1
Canada, Quebec
CISSS de la Monteregie
Greenfield Park, Quebec, Canada, J4V 2H1
Hospital Maisonneuve-Rosemont
Montreal, Quebec, Canada, H1T 2M4
CHUM - Hopital Saint-Luc
Montreal, Quebec, Canada, H2X 3J4
Ctr Sante et Services Sociaux
Trois-rivières, Quebec, Canada, G8Z 3R9
Chile
Ctr de Inv Clinica del Sur
Temuco, Araucania, Chile, 4781156
Hospital del Salvador
Providencia, Region Metropolitana De Santiago, Chile, 7500922
Biomedica Research Group
Santiago, Region Metropolitana De Santiago, Chile, 2540364
Reg. Clinical Hosptial Concepcion
Concepcion, Chile, 4070038
CALMED
La Serena, Chile, 1700000
Quantum Research Stgo.
Santiago, Chile, 7500588
Servicios Med Godoy Limitada
Santiago, Chile, 7500710
China, Anhui
Nanfang Hosp Southern Med Univ
Guangzhou, Anhui, China, 510000
Shanghai Changzheng Hosp
Shanghai, Anhui, China, 200003
Zhongshan Hosp. of Fudan Uni.
Shanghai, Anhui, China, 200032
Renji Hosp, Shanghai Jiaotong
Shanghai, Anhui, China, 200127
Shanghai 6th People`s Hospital
Shanghai, Anhui, China, 200233
China, Guangdong
Guangdong General Hospital
Guangzhou, Guangdong, China, 510080
3rd Affiliated Hosp Sun Yatsen
Guangzhou, Guangdong, China, 510630
China, Jiangsu
Jiangsu Province People's Hospital
Nanjing, Jiangsu, China, 210029
China, Shaanxi
Xijing Hospital
Xian, Shaanxi, China, 710032
China, Shanghai
Ruijin Hospital, Shanghai Jiaotong
Shanghai, Shanghai, China, 200025
Huashan Hospital affiliated to Fudan University
Shanghai, Shanghai, China, 200040
China
1st Hospital of Peking Uni
Beijing, China, 100034
Peking Univ Peoples Hospital
Beijing, China, 100034
Peking University 3rd Hospital
Beijing, China, 100191
Beijing Tongren Hospital
Beijing, China, 100730
Peking Union Med College Hosp
Beijing, China, 100730
West China Univ Hospital
Chengdu, China, 610041
1st Affiliated Hosp 3rd Milita
Chongqing, China, 400038
2nd Aff. Hosp. Dalian Med. Uni
Dalian, China, 116023
First People's Hospital Foshan
Foshan, China, 528041
2nd Hospital of Hebei Med. Uni
Jiazhuang, China, 050000
Shandong Provincial Hospital
Jinan, China, 250001
Zhongda Hosp, Southeast Univ
Nanjing, China, 210009
Ningbo No. 2 Hospital
Ningbo, China, 315010
Aff Hosp Med College Qingdao
Qingdao, China, 266003
Tongji Hosp Tongji Med College
Wuhan, China, 430030
Renmin Hospital of Wuhan Univ
Wuhan, China, 430060
1st Aff Hos Xi'an Jiaotong Uni
Xi'an, China, 710061
1st Affiliated Hosp of Zhengzh
Zhengzhou, China, 450052
Czechia
Petr Bucek s.r.o.
Frydek-mistek, Czechia, 738 01
Masarykova mestska nemocnice
Jilemnice, Czechia, 514 01
Nemocnice Novy Jicin
Nový Jicín, Czechia, 741 01
Agentur Science Pro spol s.r.o
Olomouc, Czechia, 779 00
Univ Hosp Ostrava-Poruba
Ostrava, Czechia, 708 52
Diabetologicka ambulance
Pardubice, Czechia, 53002
Fakult Nem Kralovske Vinohrady
Prague, Czechia, 100 34
Vseobecna Fakultni Nemocnice
Prague, Czechia, 128 08
Milan Kvapil s.r.o.
Prague, Czechia, 149 00
PeMedica.CZ, s.r.o.
Prague, Czechia, 155 00
Nemocnice Trebic
Trebic, Czechia, 674 01
Zahumensky, Valasske Klobouky
Valasske Klobouky, Czechia, 766 01
Denmark
Odense Universitets Hospital
Odense C, Syddanmark, Denmark, 5000
Aarhus Univ Hospital, Skejby
Aarhus, Denmark, 8200
Steno Diabetes Center
Gentofte, Denmark, 2820
Glostrup Univ Hospital
Glostrup, Denmark, 2000
Regional Hospital Holstebro
Holstebro, Denmark, 7500
Roskilde Hospital
Roskilde, Denmark, 4000
Slagelse Hospital
Slagelse, Denmark, 4200
Finland
Terveystalo Oulu
Oulu, Finland, 90100
Tampere University Hospital
Tampere, Finland, 33521
Turku University Hospital
Turku, Finland, 20520
France
Centre Hospitalier Lyon Sud
Pierre Benite CEDEX, Auvergne-Rhone-Alpes, France, 69495
CHU Bordeaux-Hopital Pellegrin
Bordeaux, France, 33076
C.H. de Corbeil Essonnes
Corbeil Essonnes, France, 91108
CHU de Grenoble - Albet Michal
Grenoble, France, 38043
Hopital de la Conception
Marseille, France, 13005
CHU de Nice
Nice, France, 06202
Hosp European, Georges Pompid
Paris, France, 75015
Clinique du Landy
Saint Ouen, France, 93400
Hopital Bretonneau - CHU Tours
Tours, France, 37044
Germany
Universitaetsklinikum Aachen
Aachen, Germany, 52074
Charité Universitätsmedizin Campus Mitte
Berlin, Germany, 10117
Klinische Forschung Berlin
Berlin, Germany, 13125
Universitaetklinikum Dresden
Dresden, Germany, 01307
DaVita Clinical Research Deuts
Dusseldorf, Germany, 40210
Dialyse am Heidering,Hanover
Hannover, Germany, 30625
St. Josefskrankenhaus
Heidelberg, Germany, 69115
Nephrologisches Zentrum
Hoyerswerda, Germany, 02977
Universitaetsklinikum Jena
Jena, Germany, 07747
Klinikum der Univ Munich
Munich, Germany, 80337
Diabetologische Schwerpunktpra
Pirna, Germany, 01796
Bieler, Riesa, DE
Riesa, Germany, 01587
Diabetologische Schwerpunktpr
Speyer, Germany, 67346
Robert-Bosch-Krankenhaus
Stuttgart, Germany, 70736
Univ-Klinikum Wuerzburg
Wuerzburg, Germany, 97080
Greece
General Hospital of Athens Laiko
Athens, Attiki, Greece, 115 27
Dimokritio University Hospital
Alexandroupoli, Greece, 68100
Genl Hosp Athens, Evangelismos
Athens, Greece, 10676
Univ Gen Hosp Ioannina
Ioannina, Greece, 45500
Sismanogleio General Hospital
Komotini, Greece, 69100
Reg Gen Univ Hosp Larissa
Larisa, Greece, 41110
University Gen Hosp of Patra
Patras, Greece, 26504
University Gen Hosp "AHEPA"
Thessaloniki, Greece, 54636
Interbalkan Medical Center
Thessaloniki, Greece, 57001
Hong Kong
Tung Wah Hospital
Hong Kong, Hong Kong, 999077
Yan Chai Hospital
Hong Kong, Hong Kong, 999077
Princess Margaret Hospital
Lai Chi Kok, Hong Kong, 999077
Queen Mary Hospital
Pok Fu Lam, Hong Kong, 999077
Prince of Wales Hospital
Sha Tin, Nt, Hong Kong, 999077
Our Lady Maryknoll Hospital
Wong Tai Sin, Hong Kong, 999077
Ireland
Cork University Hospital
Cork, Ireland, T12 E8YV
St Vincent's University Hosp
Dublin, Ireland, D04 T6F4
Connolly Hospital
Dublin, Ireland, D15 X40D
The Adelaide Meath Hospital
Dublin, Ireland, D24 NR0A
University Hospital Limerick
Limerick, Ireland, V94F858
Israel
Tel Aviv Sourasky Medical Ctr
Tel Aviv-Yafo, Tel-Aviv, Israel, 6423906
Ha'Emek Medical Center
Afula, Israel, 18341
Barzilai Medical Center
Ashkelon, Israel, 78278
Assaf Harofeh Medical Center
Be'er Ya'akov, Israel, 70300
Maccabi Health Services
Gush Dan, Israel, 7565016
Rambam Health Care Campus
Haifa, Israel, 3109601
The Lady Davis Carmel MC
Haifa, Israel, 3436212
The Edith Wolfson Medical Cent
Holon, Israel, 58100
Shaare Zedek Medical Center
Jerusalem, Israel, 91031
Meir Medical Center
Kfar Saba, Israel, 44281
Sheba Medical Center
Ramat Gan, Israel, 5262100
Kaplan Medical Center
Rehovot, Israel, 76100
Ziv Medical Center
Safed, Israel, 13100
DMC Diabetes Medical Center
Tel Aviv, Israel, 51549
Italy
Universita della Campania Luigi Vanvitelli
Napoli, Campania, Italy, 80131
A.O.U. Policlinico S.Orsola-Malpighi
Bologna, Emilia-Romagna, Italy, 40138
ASST Grande Ospedale Metropolitano Niguarda
Milano, Lombardia, Italy, 20162
A.O. Univ Consorziale Policlin
Bari, Italy, 70124
ASST Papa Giovanni XXIII
Bergamo, Italy, 24127
Azienda Ospedaliera G. Brotzu
Cagliari, Italy, 09047
Osp San Giacomo Apost Az. ULSS
Castelfranco Veneto, Italy, 31033
Azienda Socio-Sanitaria Territ
Cremona, Italy, 26100
Azienda Ospedaliera Univ San M
Genoa, Italy, 16132
Azienda Socio-Sanitaria Terrir
Lecco, Italy, 23900
Ospedale Versilia
Lido Di Camaiore, Italy, 55041
A.O.U. Policlinico G. Martino
Messina, Italy, 98125
Azienda Ospedaliera San Paolo
Milan, Italy, 20142
Osp S. Maria della Pieta Naple
Naples, Italy, 80035
University of Naples Federico
Naples, Italy, 80131
Ospedale S. Maria del Popolo
Naples, Italy, 80137
Osp Civile San Giovanni di Dio
Olbia, Italy, 07026
Fondazione IRCCS Policlinico
Pavia, Italy, 27100
IRCCS Fondazione Salva Maugeri
Pavia, Italy, 27100
ASL Cagliari
Quartu Sant'elena, Italy, 09045
AO Bianchi Melacrino Morelli
Reggio Calabria, Italy, 89125
Policlinico Univ Tor Vergata
Rome, Italy, 00133
Azienda Ospedaliera Sant' Andr
Rome, Italy, 00189
IRCCS Casa Sollievo
San Giovanni Rotondo, Italy, 71013
Azi Soc Sanitaria Territoriale
Varese, Italy, 21100
Japan
Fukuoka Univ Chikushi Hosp
Chikushino, Fukuoka, Japan, 818-8502
National Hospital Organization Asahikawa Medical Center
Asahikawa, Hokkaido, Japan, 070-8644
JA Toride Medical Center
取手市, Ibaraki, Japan, 〒302-0022
Dokkyo Medical University Saitama Medical Center
越谷市, Saitama, Japan, 〒343-0813
Tokushima University Hospital
Tokushima-shi, Tokushima, Japan, 770-8503
Nakadori General Hospital
Akita, Japan, 010-8577
NHO Chiba-East-Hospital
Chiba, Japan, 260-8712
Harada Clinic
Fukuoka, Japan, 812-0894
JP Red Cross Fukuoka Hosp
Fukuoka, Japan, 815-8555
Kyushu Cent Hosp Mutual Aid
Fukuoka, Japan, 815-8588
Funabashi Municipal Med Ctr
Funabashi, Japan, 273-0853
Anzai Clinic
Hakodate, Japan, 041-0851
Hamamatsu Medical Center
Hamamatsu, Japan, 432-8002
Higashihiroshima Medical Ctr
Higashihiroshima, Japan, 739-0041
Iwata City Hospital
Iwata, Japan, 438-0002
Rinku General Medical Center
Izumisano, Japan, 598-8577
Shimane University Hospital
Izumo, Japan, 693-0021
Tempozan Clinic of Internal Me
Kagoshima, Japan, 890-0061
Kasugai Municipal Hospital
Kasugai, Japan, 486-8510
Kawanishi City Hospital
Kawanishi, Japan, 666-0195
St. Marianna Univ Hospital
Kawasaki, Japan, 216-8511
Kokura Memorial Hospital
Kitakyushu, Japan, 802-0001
Kobe City Medical Center West
Kobe, Japan, 653-0013
Shimizu Internal Medicine Clin
Kodaira, Japan, 187-0003
Showa General Hospital
Kodaira, Japan, 187-8510
Itabashi Clinic
Koga, Japan, 306-0232
Kumamoto Medical Center
Kumamoto, Japan, 860-0008
Kawasaki Medical School Hosp
Kurashiki, Japan, 701-0114
St. Mary's Hospital
Kurume, Japan, 830-8543
Takeda General Hospital
Kyoto, Japan, 601-1434
Kyoto City Hospital
Kyoto, Japan, 604-8845
Rakuwakai Otowa Hosptial
Kyoto, Japan, 607-8062
Matsue Red Cross Hospital
Matsue, Japan, 690-8506
Matsuyama Shimin Hospital
Matsuyama, Japan, 790-0067
Saiseikai Matsuyama Hospital
Matsuyama, Japan, 791-8026
Chita Kosei Hospital
Mihama, Japan, 470-2404
Miyazaki Prefectural Miyazaki
Miyazaki, Japan, 880-8510
Ato Internal Medicine Clinic
Muroran, Japan, 050-0073
Meitetsu Hospital
Nagoya, Japan, 451-8511
Chubu Rosai Hospital
Nagoya, Japan, 455-8530
NHO Nagoya Medical Center
Nagoya, Japan, 460-0001
Nakakinen Clinic
Naka, Japan, 311-0113
Saiseikai Niigata Daini Hosp
Niigata, Japan, 950-1104
Kobari General Clinic
Noda, Japan, 278-0004
Obihiro Dai-ichi Hospital
Obihiro, Japan, 080-0014
Jiyugaoka Yamada Clinic
Obihiro, Japan, 080-0848
Takagi Hospital
Okawa, Japan, 831-0016
Osaka Gyoumeikan Hospital
Osaka, Japan, 554-0012
Osaka General Medical Center
Osaka, Japan, 558-8558
Otsu City Hospital
Otsu, Japan, 520-0804
Koshigaya Municipal Hospital
Saga, Japan, 840-8571
Asama General Hospital
Saku, Japan, 385-0022
Sanuki Municipal Hospital
Sanuki, Japan, 769-2321
Sapporo Medical Center NTT EC
Sapporo, Japan, 060-0061
Manda Memorial Hospital
Sapporo, Japan, 060-0062
Ibaraki Seinan Med Ctr Hosp
Sashima-gun, Japan, 306-0433
Suruga Clinic
Shizuoka, Japan, 424-0855
Shunan City Shinnanyo Hospital
Shunan, Japan, 746-0017
Takahashi Hosp, Social Medical
Takahashi, Japan, 716-0061
Takamatsu Red Cross Hospital
Takamatsu, Japan, 760-0017
Takatsuki Red Cross Hospital
Takatsuki-shi, Japan, 569-1045
Tamana Central Hospital
Tamana, Japan, 865-0064
The Institute for Adult Diseas
Tokyo, Japan, 103-0002
Tokyo-Eki Center-Building Clin
Tokyo, Japan, 103-0027
Sato Medical Clinic
Tokyo, Japan, 143-0015
MAKITA General Hospital
Tokyo, Japan, 143-0016
Tokyo Kamata Medical Center
Tokyo, Japan, 144-0035
National Ctr Global Health Med
Tokyo, Japan, 162-8655
Toyota Memorial Hospital
Toyota, Japan, 471-8513
Mie Central Medical Center
TSU, Japan, 514-1101
Fujii Clinic
UBE, Japan, 755-0067
NHO Shinshu Ueda Medical Ctr
Ueda, Japan, 386-8610
Urasoe Sogo Hospital
Urasoe, Japan, 901-2132
Okamoto Internal Medicine Offi
Yaizu, Japan, 425-0022
Tokui Internal Medicine Clinic
Yokohama, Japan, 220-0004
HEC Science Clinic
Yokohama, Japan, 235-0045
NHO Yokohama Medical Center
Yokohama, Japan, 245-8575
Nakajima Naika Clinic
Yokosuka, Japan, 238-0011
Korea, Republic of
Dong-A University Hospital
Busan, Busan Gwang Yeogsi, Korea, Republic of, 49201
Pusan National University Hosp
Busan, Busan Gwang Yeogsi, Korea, Republic of, 602-739
Kyungpook National Univ Hosp
Daegu, Daegu Gwang Yeogsi, Korea, Republic of, 41944
Yeungnam University Med Ctr
Daegu, Daegu Gwang Yeogsi, Korea, Republic of, 42415
Chungnam National University Hospital
Jung-gu, Daejeon Gwang Yeogsi, Korea, Republic of, 35015
CHA bundang medical center, CHA University
Seongnam-si, Gyeonggido, Korea, Republic of, 13496
Seoul National Univ Bundang ho
Seongnam, Gyeonggido, Korea, Republic of, 13620
Ajou University Hospital
Suwon-si, Gyeonggido, Korea, Republic of, 16499
Gachon University Gill Hosp
Incheon, Incheon Gwang Yeogsi, Korea, Republic of, 21565
Kyung Hee University Medical Center
Dongdaemun-gu, Seoul Teugbyeolsi, Korea, Republic of, 02447
Samsung Medical Center
Gangnam-gu, Seoul Teugbyeolsi, Korea, Republic of, 06351
Seoul National University Hospital
Jongno-gu, Seoul Teugbyeolsi, Korea, Republic of, 03080
Severance Hospital
Seoul, Seoul Teugbyeolsi, Korea, Republic of, 03722
Asan Medical Center
Seoul, Seoul Teugbyeolsi, Korea, Republic of, 05505
Gangnam Severance Hospital
Seoul, Seoul Teugbyeolsi, Korea, Republic of, 06273
Cath Univ Seoul St Mary's Hosp
Seoul, Seoul Teugbyeolsi, Korea, Republic of, 06591
Korea Universtiy Guro Hospital
Seoul, Seoul Teugbyeolsi, Korea, Republic of, 08308
Soonchunhayng Univ Bucheon Hos
Bucheon, Korea, Republic of, 420-767
Bucheon St. Mary's hospital
Bucheon, Korea, Republic of, 420-818
Chungbuk National Univ Hosp
Cheongju, Korea, Republic of, 361-240
Chuncheon Sacred Heart Hosp
Chuncheon, Korea, Republic of, 200-704
Keimyung Univ Dongsan medical
Daegu, Korea, Republic of, 700-712
Daegu Catholic University Med
Daegu, Korea, Republic of, 705-718
Cath Univ Korea St Paul's Hosp
Dongdaemun-gu, Korea, Republic of, 130-709
Wonju Severance Christian Hosp
Gangwon-do, Korea, Republic of, 26426
Myongji Hospital
Goyang, Korea, Republic of, 412-270
Hanyang University Guri Hosp
Guri-si, Korea, Republic of, 471-701
Chosun University Hospital
Gwangju, Korea, Republic of, 61453
Korea University Ansan Hosp
Gyeonggi-do, Korea, Republic of, 152-703
Wonkwang University
Iksan, Korea, Republic of, 570-711
Jeju National University Hospi
Jeju, Korea, Republic of, 690-767
Chonbuk National Univ Hosp
Jeonju, Korea, Republic of, 561-712
Korea University Anam Hospital
Seoul, Korea, Republic of, 02841
Hallym Univ Kangdong Sacred
Seoul, Korea, Republic of, 134-701
Uijeongbu St. Mary's Hospital
Uijeongbu, Korea, Republic of, 480-717
Ulsan University Hospital
Ulsan, Korea, Republic of, 682-714
Malaysia
Hospital Sultanah Bahiyah
Alor Setar, Kedah, Malaysia, 05460
Hospital Raja Perempuan Zainab II
Kota Bharu, Kelantan, Malaysia, 15586
Hospital Pulau Pinang
Georgetown, Pulau Pinang, Malaysia, 10450
Hospital Selayang
Batu Caves, Malaysia, 68100
Hospital Universiti Kebangsaan
Cheras, Malaysia, 56000
Klinik Kesihatan Greentown
Ipoh, Malaysia, 30450
Hospital Sultanah Aminah
Johor Bahru, Malaysia, 80100
Hospital Serdang
Kajang, Malaysia, 43000
University Sains Malaysia
Kota Bharu, Malaysia, 16150
Hospital Kuala Lumpur
Kuala Lumpur, Malaysia, 50586
Hospital Tengku Ampuan Afzan
Kuantan, Malaysia, 25100
Hospital Melaka
Melaka, Malaysia, 75400
Monash University Malaysia
Petaling Jaya, Malaysia, 46150
Hospital Putrajaya
Putrajaya, Malaysia, 62250
Hospital Queen Elizabeth II
Sabah, Malaysia, 88300
Hospital Tuanku Ja afar
Seremban, Malaysia, 70300
Hospital Taiping
Taiping, Malaysia, 34000
Mexico
Centro Invest. Clinica del Pac
Acapulco, Mexico, 39670
Clinica San Cosme
Aguascalientes, Mexico, 20129
Inst Diabetes Obesidad Nutri
Cuernavaca, Mexico, 62250
Investigacion Nefrologica S.C.
Cuernavaca, Mexico, 62448
Inst Invest Diabetes Obesidad
Guadalajara, Mexico, 04460
Area Medica SANEFRO
Guadalajara, Mexico, 44190
INCMN Salvador Zubrian
Mexico City, Mexico, 14080
Paracelsus, S.A. de C.V.
Mexico City, Mexico, 38000
Hospital y Clinica OCA
Monterrey, Mexico, 64000
Hosp Univ Jose Eleuterio Gonza
Monterrey, Mexico, 64460
Uni Prevencion Atencion Cardio
Morelia, Mexico, 58260
Hosp Central Dr. I. M. Prieto
San Luis Potosí, Mexico, 78240
Instituto Nacional del Cancer
Tlapan, Mexico, 14080
Netherlands
Academisch Medisch Centrum
Amsterdam, Noord-Holland, Netherlands, 1105 AZ
Ziekenhuis Groep Twente
Almelo, Netherlands, 7609 PP
Meander Medisch Centrum
Amersfoort, Netherlands, 3813 TZ
Gelre Hospital Apeldoorn
Apeldoorn, Netherlands, 7334 DZ
Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands, 3318 AT
Univ Med Center Groningen
Groningen, Netherlands, 9713 GZ
New Zealand
Waikato Hospital
Hamilton, Waikato, New Zealand, 3204
North Shore Hospital
Auckland, New Zealand, 0622
Auckland City Hospital
Auckland, New Zealand, 1023
Middlemore Clinical Trials
Auckland, New Zealand, 2025
Canterbury District Health Boa
Christchurch, New Zealand, 8011
Dunedin Hospital
Dunedin, New Zealand, 9016
Taranaki Base Hospital
New Plymouth, New Zealand, 4310
Peru
Exacta Lab SAC
Arequipa, Peru, 04000
Instituto Delgado de Inv Med
Arequipa, Peru, 04001
Instituto Endo Farfan Eirl
Arequipa, Peru, 04001
Hosp Nac Adolfo Guevara Velasc
Cusco, Peru, 08001
Hosp Nacional Alberto Sabogal
El Callao, Peru, 07011
Hosp Nacional Arzobispo Loayza
Lima, Peru, 15001
Clinica de Diabetes S.A.C.
Lima, Peru, 15073
Ctr Invest Atencion Cardio SAC
Lima, Peru, 15076
Ctr Med Clinic San Judas Tadeo
Lima, Peru, 15086
Clinica Virgen Maria Auxiliado
Piura, Peru, 20000
Poland
Medica Pro Familia S.A Warszawa
Warsaw, Mazowieckie, Poland, 01-869
NZOZ Specjalistyczny Osodek
Bialystok, Poland, 15-435
NZOZ Diab Serwis S.C.
Chorzow, Poland, 41-500
Samodzielny Publiczny Szpital
Katowice, Poland, 40-027
Nzoz Salvia
Katowice, Poland, 40-772
Krakowskie Centrum Medyczne
Krakow, Poland, 31-501
Centrum Medyczne ProMiMed Sp
Krakow, Poland, 31-637
SPZOZ Uniwersytecki Szpital Kl
Lodz, Poland, 02-213
NZOZ Przychodnia Specjalistycz
Lublin, Poland, 20-538
Centrum Medyczne Medyk
Rzeszow, Poland, 35-055
Centrum Uslug Medycznych Diali
Szczecinek, Poland, 78-400
Samodzielny Publiczny Szpital
Szczecin, Poland, 71-899
Portugal
Hospital Garcia de Orta, E.P.E
Almada, Lisboa, Portugal, 2805-267
Centro Hospitalar do Algarve
Faro, Portugal, 8000-386
Centro Hospitalar Lisboa Norte, EPE
Lisboa, Portugal, 1649-035
Associacao Protectora dos Diab
Lisbon, Portugal, 1050-078
Hospital Pulido Valente
Lisbon, Portugal, 1769-001
Hospital do Espirito Santo
Ponta Delgada, Portugal, 9500-370
Centro Hospitalar do Porto
Porto, Portugal, 4099-001
Puerto Rico
Hospital Bayamon Health Center
Bayamon, Puerto Rico, 00961
Instituto Renal del Este
Caguas, Puerto Rico, 00725
Advanced Medical Concepts. PSC
Cidra, Puerto Rico, 00739
PR Renal Health and Research I
Ponce, Puerto Rico, 00716
Endo Lipid Diabetes Res Inst
Ponce, Puerto Rico, 00717
Research & Cardiovascular Corp
Ponce, Puerto Rico, 00717
Caparra Internal Medicine
Rio Grande, Puerto Rico, 00745
Pavia Research Center, LLC
San Juan, Puerto Rico, 00909
Nephrology Private Practice
San Juan, Puerto Rico, 00918
VA Caribbean Healthcare System
San Juan, Puerto Rico, 00921-3201
University of Puerto Rico, School of Medicine
San Juan, Puerto Rico, 00935
Cent. Endocrin Alcantara-Gonz.
San Juan, Puerto Rico, 00956
Romania
O.D. Medica SRL
Bucuresti, Romania, 020992
Spitalul Clinic Judetean de Ur
Cluj, Romania, 400006
Centrul Medical Unirea SRL
Cluj, Romania, 400349
Spitalul Clinic Judetean de Ur
Constanta, Romania, 900002
Milena Sante SRL
Galati, Romania, 800001
Consultmed SRL
Iasi, Romania, 700547
Municipal Clin Hosp, Curteanu
Oradea, Romania, 410469
Spitalul Judetean de Urgenta P
Pitesti, Romania, 110084
SC Centrul Med Sfantul Stefan
Timisoara, Romania, 300125
Sp. Clinic de Judetean
Timisoara, Romania, 300736
Russian Federation
Republican Clinical hospital
Kazan, Tatarstan, Respublika, Russian Federation, 420064
archangel Clinical Oncology
Arkhangelsk, Russian Federation, 163045
Regional Clinical Hospital
Barnaul, Russian Federation, 656024
City Hospital No 6
Chelyabinsk, Russian Federation, 454047
Clinic of New Technologies of
Dzerzhinsk, Russian Federation, 140091
Gatchina Central District Clin
Gatchina, Russian Federation, 188300
Irkutsk State Medical Academy
Irkutsk, Russian Federation, 664049
Kemerovo Regional Hospital
Kemerovo, Russian Federation, 650000
Kirov City Clin Hospital 1
Kirov, Russian Federation, 610035
Krasnoyarsk Interdistrict Clin
Krasnoyarsk, Russian Federation, 660062
City Hosp #23 n.a. Medsantrud
Moscow, Russian Federation, 109240
Endocrinology Research Ct
Moscow, Russian Federation, 117036
People's Friendship University
Moscow, Russian Federation, 117198
Moscow State Med Univ Sech
Moscow, Russian Federation, 119435
Moscow - Out-patient Clinic #3
Moscow, Russian Federation, 123001
City Clinical Hospital No. 52
Moscow, Russian Federation, 123182
City Hosp 33 Nizhniy Novgorod
Nizhnij Novgorod, Russian Federation, 603076
Scientific Institution
Novosibirsk, Russian Federation, 630117
Orenburg State Medical Academy
Orenburg, Russian Federation, 460000
Perm Regional Hospital
Perm, Russian Federation, 614990
Republican Clin Hos n.a. Baran
Petrozavodsk, Russian Federation, 185019
GBOU VPO Saratov State Med Uni
Saratov, Russian Federation, 410012
Smolensk State Medical Academy
Smolensk, Russian Federation, 214019
Federal State Budgetary Scient
St. Petersburg, Russian Federation, 192019
NW State Med Univ NA Mechnikov
St. Petersburg, Russian Federation, 193015
Diagnostic Center No.1
St. Petersburg, Russian Federation, 194354
City Out-patient Clinic #17
St. Petersburg, Russian Federation, 195176
City Clinical Hospital # 38
St. Petersburg, Russian Federation, 196601
St. Petersburg State Medical U
St. Petersburg, Russian Federation, 197022
City Clinical Hospital # 31
St. Petersburg, Russian Federation, 197110
Research Institute for Cardio
Tomsk, Russian Federation, 634012
Siberian State Med Uni
Tomsk, Russian Federation, 634050
Regional Clinical Hospital
Yaroslavl, Russian Federation, 150062
Singapore
National University Hospital
Singapore, Singapore, 119074
Singapore General Hospital
Singapore, Singapore, 169608
Tan Tock Seng Hospital
Singapore, Singapore, 308433
Khoo Teck Puat Hospital
Singapore, Singapore, 768828
Slovakia
ProVitae-Medical Centre
Bratislava, Slovakia, 811 03
Univerzitna Nemocnica Bratisla
Bratislava, Slovakia, 821 01
FMC Dialysis Services
Bratislava, Slovakia, 82101
Metabolic Ctr. of Dr K.Raslova
Bratislava, Slovakia, 83101
Medispektrum, sro
Bratislava, Slovakia, 851 01
FMC-dialyzacne sluzby, spol.s
Hlohovec, Slovakia, 920 01
AGTO spol. s.r.o.
Kosice, Slovakia, 040 01
Medikol s.r.o.
Kosice, Slovakia, 040 01
FMC Dialyzacne sluzby s.r.o.
Kosice, Slovakia, 04011
SMOLKO s.r.o.
Kosice, Slovakia, 04011
B Braun Avitum s.r.o.
Královský Chlmec, Slovakia, 077 01
Interna SK s.r.o.
Svidnik, Slovakia, 089 01
South Africa
Phoenix Pharma
Port Elizabeth, Eastern Cape, South Africa, 6045
LCS Clinical Research Unit
Bryanston, Gauteng, South Africa, 2191
Unitas Hospital
Centurion, Gauteng, South Africa, 0140
Soweto Clinical Trial Centre
Johannesburg, Gauteng, South Africa, 1818
Makan, Lenasia, SA
Johannesburg, Gauteng, South Africa, 1827
Newtown Clinical Research Cent
Johannesburg, Gauteng, South Africa, 2001
Ctr. for Diabetes and Endo
Johannesburg, Gauteng, South Africa, 2198
Dr P J Sebastian
Chatsworth, Kwazulu-Natal, South Africa, 4092
Dr. J. Fourie Medical Center
Dundee, Kwazulu-Natal, South Africa, 3000
Netcare Parklands Hospital
Durban, Kwazulu-Natal, South Africa, 4001
St. Augustine's Hospital
Durban, Kwazulu-Natal, South Africa, 4001
Newkwa Medical Centre
Durban, Kwazulu-Natal, South Africa, 4035
Synexus Helderberg Clinical Tr
Cape Town, Western Cape, South Africa, 7130
Langeberg Clinical Trials
Cape Town, Western Cape, South Africa, 7570
Paarl Research Centre
Cape Town, Western Cape, South Africa, 7646
University of Cape Town
Cape Town, Western Cape, South Africa, 7925
Worchester Medi-Clinic
Worcester, Western Cape, South Africa, 6850
Spain
Hospital Duran i Reynals
L'Hospitalet de Llobregat, Barcelona, Spain, 08907
Corporac Sanitaria Parc Tauli
Sabadell, Barcelona, Spain, 08208
H. Un. Marques de Valdecilla
Santander, Cantabria, Spain, 39008
Comple Hosp Univ de A Coruna
A Coruna, Spain, 15006
Hospital Parc de Salut del Mar
Barcelona, Spain, 08003
Fundacion Puigvert
Barcelona, Spain, 08025
Hospital Univ Vall d'Hebron
Barcelona, Spain, 08035
Hospital Univ Germans Trias I
Barcelona, Spain, 08916
Hospital Universitario Basurto
Bilbao, Spain, 48013
Hospital da Costa
Burela, Spain, 27880
Hospital Universitario Reina S
Cordoba, Spain, 14004
Hospital Univ de Getafe
Getafe, Spain, 28905
Hosp Univ Girona Josep Trueta
Girona, Spain, 17007
Hospital Univ Dr. Negrin
Las Palmas de Gran Canaria, Spain, 35010
Hospital de Leo
Leon, Spain, 24071
Hospital Universitario Arnau de Vilanova de Lleida
Lleida, Spain, 25198
Hospital Puerta de Hierro
Madrid, Spain, 28035
Fundacion Jimenez Diaz
Madrid, Spain, 28040
Hospital Clin Univ San Carlos
Madrid, Spain, 28040
Hosp Univ 12 de Octubre
Madrid, Spain, 28041
Hosp Uni Virgen de la Victoria
Malaga, Spain, 29010
Hosp Univ Nuestra Candelaria
Santa Cruz de Tenerife, Spain, 38010
Hospital Universitario Virgen Macarena
Sevilla, Spain, 41009
Hospital Univ Mutua Terrassa
Terrasa, Spain, 08221
Hosp General Univ de Valencia
Valencia, Spain, 46014
Hospital Univ Dr. Peset
Valencia, Spain, 46017
Hospital Universitario La Fe
Valencia, Spain, 46026
Hospital de Txagorritxu
Vitoria, Spain, 01009
Sweden
Orebro Universitetssjukhuset
Orebro, Sweden, 70185
Uppsala University Hospital
Uppsala, Sweden, 75185
Switzerland
Kantonsspital Aarau
Aarau, Switzerland, 5001
Centre Hospitalier Univ Vaudoi
Lausanne, Switzerland, 1011
Taiwan
Kaohsiung Veterans General Hos
Kaohsiung, Taichung, Taiwan, 81362
China Medical University Hosp
Taichung City, Taichung, Taiwan, 40447
Hualien Tzu Chi Hospital
Hualien County, Taiwan, 97002
Far Eastern Memorial Hospital
New Taipei City, Taiwan, 22060
Cardinal Tien Hospital
New Taipei City, Taiwan, 23148
Chung Shan Medical University
Taichung City, Taiwan, 40201
Taichung Hospital
Taichung City, Taiwan, 40343
Taichung Veterans General Hosp
Taichung City, Taiwan, 40705
Kuang Tien General Hospital
Taichung City, Taiwan, 43303
Chi-Mei Medical Center
Tainan City, Taiwan, 71004
MacKay Memorial Hospital
Taipei City, Taiwan, 10449
Cathay General Hospital
Taipei City, Taiwan, 10630
Taipei Medical University Hosp
Taipei City, Taiwan, 11031
Linkou Chang Gung Memorial Ho
Taoyuan City, Taiwan, 33305
Turkey
Akdeniz University Medical Fac
Antalya, Turkey, 07059
Adnan Menderes University
Aydin, Turkey, 09100
Baskent Univ School of Med
Istanbul, Turkey, 06570
Istanbul University Istanbul Medical Faculty
Istanbul, Turkey, 34093
Sifa University
Izmir, Turkey, 35100
Dokuz Eylul University
Izmir, Turkey, 35340
Kocaeli University Med Faculty
Kocaeli, Turkey, 41380
Ondokuz mayis University Facul
Samsun, Turkey, 55139
Ukraine
Lviv Regional Clinical Hospita
Lviv, Lvivska Oblast, Ukraine, 79013
Clinical Research & Consulting
Vinnytsia, Vinnytska Oblast, Ukraine, 21005
Chernivtsi Regional Clinical H
Chernivtsi, Ukraine, 58000
Regional Clin Hosp Mechnykov
Dnipropetrovsk, Ukraine, 49005
Ukrainian State Institute Med
Dnipropetrovsk, Ukraine, 49027
Kharkiv City Clinical ER Hosp
Kharkiv, Ukraine, 61000
Kharkov City Clin Hospital #27
Kharkiv, Ukraine, 61000
SI Inst of Therapy AMS of UA
Kharkiv, Ukraine, 61039
Regional Clinical Hospital
Kharkov, Ukraine, 61058
ARTEM Polyclinic
Kiev, Ukraine, 04050
Institute of Nephrology NAMS
Kiev, Ukraine, 04050
Kiev Regional Clinical Hosp
Kiev, Ukraine, 04107
VP Komissarenko National Ac of Med. Sciences
Kiev, Ukraine, 04114
Mykolayiv Regional Hospital
Mykolayiv, Ukraine, 54058
Odessa Regional Clinical Hosp
Odesa, Ukraine, 65025
Ternopil University Hospital
Ternopil, Ukraine, 46002
Transcarpathian Regional Clin.
Uzhhorod, Ukraine, 88000
City Clinical Hospital No. 10
Zaporizhia, Ukraine, 69001
Reg. Clinical Hosp of Zhytomyr
Zhytomyr, Ukraine, 10003
United Kingdom
The Royal Free Hospital
London, London, City Of, United Kingdom, NW3 2QG
Guy's and St Thomas' NHS Found
London, London, City Of, United Kingdom, SE1 9RT
Belfast City Hospital
Belfast, United Kingdom, BT9 7AB
Ninewells Hospital
Dundee, United Kingdom, DD1 9SY
South Glasgow Universita Hospi
Glasgow, United Kingdom, G51 4TF
North Middlesex Hosp NHS Trust
London, United Kingdom, N18 1QX
King's College Hospital NHS
London, United Kingdom, SE5 9RS
Salford Royal NHS Found Trust
Salford, United Kingdom, M6 8HD
Sponsors and Collaborators
AbbVie
Investigators
Study Director: AbbVie Inc. AbbVie

Responsible Party: AbbVie
ClinicalTrials.gov Identifier: NCT01858532     History of Changes
Other Study ID Numbers: M11-352
2012-005848-21 ( EudraCT Number )
First Posted: May 21, 2013    Key Record Dates
Last Update Posted: April 26, 2018
Last Verified: April 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
Product Manufactured in and Exported from the U.S.: No

Keywords provided by AbbVie:
Diabetes
Nephropathy

Additional relevant MeSH terms:
Kidney Diseases
Diabetic Nephropathies
Urologic Diseases
Diabetes Complications
Diabetes Mellitus
Endocrine System Diseases
Atrasentan
Endothelin Receptor Antagonists
Molecular Mechanisms of Pharmacological Action