Trial record 1 of 1 for:    E1412
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Rituximab and Combination Chemotherapy With or Without Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Diffuse Large B Cell Lymphoma

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2016 by National Cancer Institute (NCI)
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01856192
First received: May 14, 2013
Last updated: July 28, 2016
Last verified: March 2016
  Purpose
This randomized phase II trial studies how well rituximab and combination chemotherapy with or without lenalidomide work in treating patients with newly diagnosed stage II-IV diffuse large B cell lymphoma. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Lenalidomide may stimulate the immune system in different ways and stop cancer cells from growing. It is not yet known whether rituximab and combination chemotherapy are more effective when given with or without lenalidomide in treating patients with diffuse large B cell lymphoma.

Condition Intervention Phase
Stage II Diffuse Large B-Cell Lymphoma
Stage III Diffuse Large B-Cell Lymphoma
Stage IV Diffuse Large B-Cell Lymphoma
Drug: Cyclophosphamide
Drug: Doxorubicin Hydrochloride
Other: Laboratory Biomarker Analysis
Drug: Lenalidomide
Drug: Prednisone
Biological: Rituximab
Drug: Vincristine Sulfate
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Randomized Phase II Open Label Study of Lenalidomide R-CHOP (R2CHOP) vs RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) in Patients With Newly Diagnosed Diffuse Large B Cell Lymphoma

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • PFS [ Time Frame: Time from randomization to the earliest of documented disease progression, new primaries of the same type or death without progression, assessed up to 10 years ] [ Designated as safety issue: No ]
    The primary analysis of PFS will be performed including all randomized eligible patients using a one-sided log-rank test stratified on IPI (2-3 vs. 4-5), age (< 60 years vs >= 60 years) and molecular subtype (germinal center B-cell type [GCB] vs. activated B-cell type [ABC]). Cox proportional hazards models will be used to assess possible effects of baseline clinical and biological characteristics on outcome, including age, gender, disease stage, and IPI. Treatment and covariate interactions will also be examined.


Secondary Outcome Measures:
  • CR rate based on PET-CT scan [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    The comparison of CR between two arms will be performed with CMH test, stratified on IPI (2-3 vs 4-5), age (< 60 yrs vs >= 60 yrs) and molecular subtype (GCB vs. ABC). Exploratory logistic regression will be used to assess possible effects of baseline clinical and biological characteristics on outcome, including age, gender, disease stage, and IPI. Treatment and covariate interactions will also be examined.

  • OS [ Time Frame: Time from randomization until death due to any cause, assessed up to 10 years ] [ Designated as safety issue: No ]
    The method of Kaplan and Meier will be used to estimate OS, and stratified log-rank test will be used to compare OS between two arms.

  • Overall RR based on PET-CT scan [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    The comparison of RR between two arms will be performed with Cochran-Mantel-Haenszel (CMH) test, stratified on IPI (2-3 vs 4-5), age (< 60 yrs vs >= 60 yrs) and molecular subtype (GCB vs. ABC). Exploratory logistic regression will be used to assess possible effects of baseline clinical and biological characteristics on outcome, including age, gender, disease stage, and IPI. Treatment and covariate interactions will also be examined.


Other Outcome Measures:
  • Impact of DLBCL molecular subtype on outcome [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    Analysis will be based on classification by gene expression profile from paraffin-embedded tissue. A stratified log-rank test and Cochran-Mantel-Haenszel test will be used to compare PFS and RR between two molecular subtypes, respectively. Other secondary outcomes, including overall RR and OS will be compared using similar methods.

  • Relation between interim PET scan and study outcome [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 345
Study Start Date: August 2013
Estimated Primary Completion Date: January 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm A (rituximab, combination chemotherapy, lenalidomide)
Patients receive rituximab IV, cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone PO on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
Drug: Cyclophosphamide
Given IV
Other Names:
  • (-)-Cyclophosphamide
  • 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate
  • Carloxan
  • Ciclofosfamida
  • Ciclofosfamide
  • Cicloxal
  • Clafen
  • Claphene
  • CP monohydrate
  • CTX
  • CYCLO-cell
  • Cycloblastin
  • Cycloblastine
  • Cyclophospham
  • Cyclophosphamid monohydrate
  • Cyclophosphamidum
  • Cyclophosphan
  • Cyclophosphane
  • Cyclophosphanum
  • Cyclostin
  • Cyclostine
  • Cytophosphan
  • Cytophosphane
  • Cytoxan
  • Fosfaseron
  • Genoxal
  • Genuxal
  • Ledoxina
  • Mitoxan
  • Neosar
  • Revimmune
  • Syklofosfamid
  • WR- 138719
Drug: Doxorubicin Hydrochloride
Given IV
Other Names:
  • 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)
  • ADM
  • Adriacin
  • Adriamycin
  • Adriamycin Hydrochloride
  • Adriamycin PFS
  • Adriamycin RDF
  • ADRIAMYCIN, HYDROCHLORIDE
  • Adriamycine
  • Adriblastina
  • Adriblastine
  • Adrimedac
  • Chloridrato de Doxorrubicina
  • DOX
  • DOXO-CELL
  • Doxolem
  • Doxorubicin.HCl
  • Doxorubin
  • Farmiblastina
  • FI 106
  • FI-106
  • hydroxydaunorubicin
  • Rubex
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Lenalidomide
Given PO
Other Names:
  • CC-5013
  • CC5013
  • CDC 501
  • Revlimid
Drug: Prednisone
Given PO
Other Names:
  • .delta.1-Cortisone
  • 1, 2-Dehydrocortisone
  • Adasone
  • Cortancyl
  • Dacortin
  • DeCortin
  • Decortisyl
  • Decorton
  • Delta 1-Cortisone
  • Delta-Dome
  • Deltacortene
  • Deltacortisone
  • Deltadehydrocortisone
  • Deltasone
  • Deltison
  • Deltra
  • Econosone
  • Lisacort
  • Meprosona-F
  • Metacortandracin
  • Meticorten
  • Ofisolona
  • Orasone
  • Panafcort
  • Panasol-S
  • Paracort
  • PRED
  • Predicor
  • Predicorten
  • Prednicen-M
  • Prednicort
  • Prednidib
  • Prednilonga
  • Predniment
  • Prednisonum
  • Prednitone
  • Promifen
  • Servisone
  • SK-Prednisone
Biological: Rituximab
Given IV
Other Names:
  • ABP 798
  • BI 695500
  • C2B8 Monoclonal Antibody
  • Chimeric Anti-CD20 Antibody
  • CT-P10
  • IDEC-102
  • IDEC-C2B8
  • IDEC-C2B8 Monoclonal Antibody
  • MabThera
  • Monoclonal Antibody IDEC-C2B8
  • PF-05280586
  • Rituxan
  • Rituximab Biosimilar ABP 798
  • Rituximab Biosimilar BI 695500
  • Rituximab Biosimilar CT-P10
  • Rituximab Biosimilar PF-05280586
  • Rituximab Biosimilar RTXM83
  • RTXM83
Drug: Vincristine Sulfate
Given IV
Other Names:
  • Kyocristine
  • Leurocristine Sulfate
  • Leurocristine, sulfate
  • Oncovin
  • Vincasar
  • Vincosid
  • Vincrex
  • Vincristine, sulfate
Active Comparator: Arm B (rituximab, combination chemotherapy)
Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
Drug: Cyclophosphamide
Given IV
Other Names:
  • (-)-Cyclophosphamide
  • 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate
  • Carloxan
  • Ciclofosfamida
  • Ciclofosfamide
  • Cicloxal
  • Clafen
  • Claphene
  • CP monohydrate
  • CTX
  • CYCLO-cell
  • Cycloblastin
  • Cycloblastine
  • Cyclophospham
  • Cyclophosphamid monohydrate
  • Cyclophosphamidum
  • Cyclophosphan
  • Cyclophosphane
  • Cyclophosphanum
  • Cyclostin
  • Cyclostine
  • Cytophosphan
  • Cytophosphane
  • Cytoxan
  • Fosfaseron
  • Genoxal
  • Genuxal
  • Ledoxina
  • Mitoxan
  • Neosar
  • Revimmune
  • Syklofosfamid
  • WR- 138719
Drug: Doxorubicin Hydrochloride
Given IV
Other Names:
  • 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)
  • ADM
  • Adriacin
  • Adriamycin
  • Adriamycin Hydrochloride
  • Adriamycin PFS
  • Adriamycin RDF
  • ADRIAMYCIN, HYDROCHLORIDE
  • Adriamycine
  • Adriblastina
  • Adriblastine
  • Adrimedac
  • Chloridrato de Doxorrubicina
  • DOX
  • DOXO-CELL
  • Doxolem
  • Doxorubicin.HCl
  • Doxorubin
  • Farmiblastina
  • FI 106
  • FI-106
  • hydroxydaunorubicin
  • Rubex
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Prednisone
Given PO
Other Names:
  • .delta.1-Cortisone
  • 1, 2-Dehydrocortisone
  • Adasone
  • Cortancyl
  • Dacortin
  • DeCortin
  • Decortisyl
  • Decorton
  • Delta 1-Cortisone
  • Delta-Dome
  • Deltacortene
  • Deltacortisone
  • Deltadehydrocortisone
  • Deltasone
  • Deltison
  • Deltra
  • Econosone
  • Lisacort
  • Meprosona-F
  • Metacortandracin
  • Meticorten
  • Ofisolona
  • Orasone
  • Panafcort
  • Panasol-S
  • Paracort
  • PRED
  • Predicor
  • Predicorten
  • Prednicen-M
  • Prednicort
  • Prednidib
  • Prednilonga
  • Predniment
  • Prednisonum
  • Prednitone
  • Promifen
  • Servisone
  • SK-Prednisone
Biological: Rituximab
Given IV
Other Names:
  • ABP 798
  • BI 695500
  • C2B8 Monoclonal Antibody
  • Chimeric Anti-CD20 Antibody
  • CT-P10
  • IDEC-102
  • IDEC-C2B8
  • IDEC-C2B8 Monoclonal Antibody
  • MabThera
  • Monoclonal Antibody IDEC-C2B8
  • PF-05280586
  • Rituxan
  • Rituximab Biosimilar ABP 798
  • Rituximab Biosimilar BI 695500
  • Rituximab Biosimilar CT-P10
  • Rituximab Biosimilar PF-05280586
  • Rituximab Biosimilar RTXM83
  • RTXM83
Drug: Vincristine Sulfate
Given IV
Other Names:
  • Kyocristine
  • Leurocristine Sulfate
  • Leurocristine, sulfate
  • Oncovin
  • Vincasar
  • Vincosid
  • Vincrex
  • Vincristine, sulfate

Detailed Description:

PRIMARY OBJECTIVES:

I. Progression-free survival (PFS).

SECONDARY OBJECTIVES:

I. Response rate (RR). II. Complete remission (CR) rate as defined by positron emission tomography (PET)-computed tomography (CT) criteria.

III. Overall survival (OS).

TERTIARY OBJECTIVES:

I. Impact of diffuse large B cell lymphoma (DLBCL) molecular subtype on outcome.

II. Interim PET scan results in relation to treatment outcome.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive rituximab intravenously (IV), cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone orally (PO) on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patient are followed up every 3 months for 2 years, every 6 months for 1 year, and then annually for up to 7 years.

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • PRE-REGISTRATION (STEP 0)
  • Histologically confirmed DLBCL expressing cluster of differentiation (CD)20 antigen; patients with transformed lymphoma are excluded; in this regard, patients with composite lymphoma in the diagnostic tissue (concomitant DLBCL and follicular or other low-grade lymphoma component) are excluded; however, patients with DLBCL in primary diagnostic tissue but a bone marrow that shows low grade or indeterminate lymphoma are eligible; patients with known primary mediastinal large B-cell lymphoma (PMLBCL) are excluded; similarly, patients with known v-myc myelocytomatosis viral oncogene homolog (avian) (c-myc) translocation (by fluorescence in situ hybridization) positive DLBCL are encouraged to participate in trials specifically designed for these patients; however patients with known c-myc DLBC positive are NOT excluded from this study; c-myc testing prior to study enrollment is NOT required
  • Stages II bulky disease (defined as mass size of more than 10 cm), stage III, or IV (Ann Arbor staging); patients with stage I and stage II non-bulky disease are excluded from this study
  • A paraffin-embedded tumor tissue specimen from the initial diagnostic biopsy has been located and ready to ship to the Mayo Clinic Lymphoma Laboratory following pre-registration; Note: exisional tumor biopsy is preferred; core needle biopsies will be considered adequate if there is enough tissue for the mandatory central pathology review immunohistochemistry and Genomics Education Partnership (GEP); submission of a tumor block is preferred, but if unavailable submit alternative materials
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • Previously untreated and not receiving any other agent that would be considered as a treatment for the lymphoma; for subjects with severe systemic symptoms, compressive disease, or rapidly progressing symptomatic adenopathy, are allowed for lymphoma associated symptom treatment with up to 1 mg/kg/day prednisone, or equivalent, for a maximum of 7 days is permitted prior to beginning the treatment, at the discretion of the investigator; a washout period does not apply
  • No known central nervous system (CNS) lymphoma or cerebrospinal fluid involvement with malignant lymphoma cells; these patients are usually treated with CNS directed therapy; screening for cerebrospinal fluid (CSF)/CNS involvement is NOT required but can be performed per treating medical doctor (MD) discretion; intrathecal (IT) methotrexate or IT cytarabine prophylaxis in patients with negative CSF who are felt to be at high risk of CNS relapse is allowed per local MD discretion; this should be noted on the treatment form
  • Absence of history of myocardial infarction =< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias
  • Absence of history of deep venous thrombosis/embolism, threatening thromboembolism or known thrombophilia; patients with a history of deep vein thrombosis(DVT)/pulmonary embolism (PE) or thrombophilia may participate if they are willing to be on full anticoagulation during the treatment if randomized to rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R2CHOP) arm A; full anticoagulation is defined as warfarin, factor X inhibitors, or low molecular weight heparin at therapeutic doses
  • Patient must be able and willing to receive anticoagulation therapy with aspirin 70-325 mg daily prophylaxis, low molecular weight heparin, factor X inhibitors or warfarin; patients unable or unwilling to take any prophylaxis are NOT eligible
  • Absence of history of acquired immune deficiency syndrome (AIDS)-related conditions (other than the presenting DLBCL) or post-transplant lymphoproliferative disorder (PTLD) in immunocompromised patients; patients with human immunodeficiency virus (HIV) on antiretroviral therapy other than zidovudine (AZT) and/or stavudine and without prior AIDS defining conditions and adequate CD4 count (> 400) are eligible
  • No other active malignancy requiring therapy such as radiation, chemotherapy, or immunotherapy; exceptions to this are as follows: localized non-melanotic skin cancer and any cancer that in the judgment of the investigator has been treated with curative intent and will not interfere with the study treatment plan and response assessment
  • No history of radiation therapy to >= 25% of the bone marrow for other diseases or history of anthracycline therapy
  • Patients must not be receiving erythroid stimulating agents (erythropoietin [EPO]: Procrit, Aranesp)
  • RANDOMIZATION (STEP 1)
  • Patient meets the eligibility criteria outlined above
  • Site has received notification from Mayo Clinic - Rochester Division of Hematopathology of the central confirmation of diagnosis and tissue adequacy for mandatory research studies
  • Patients must have measurable disease (at least 1 lesion of >= 1.5 cm in one diameter) as detected by computed tomography (CT) or the CT images of the positron emission tomography (PET)/CT
  • International Prognostic Index (IPI) of 2 or greater
  • Ejection fraction of >= 45% by either multi-gated acquisition (MUGA) scan or echocardiogram (ECHO)
  • Absence of co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens, including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Absolute neutrophil count (ANC) >= 1500
  • Platelets (PLT) >= 100,000
  • Total bilirubin =< 1.5 x upper limit of normal (ULN) or if total bilirubin is > 1.5 x ULN, the direct bilirubin must be normal
  • Alkaline (Alk.) phosphatase =< 3 x ULN unless evidence of the direct liver involvement by lymphoma - then =< 5 x ULN
  • Aspartate aminotransferase (AST) =< 3 x ULN unless evidence of the direct liver involvement by lymphoma - then =< 5 x ULN
  • Creatinine =< 2 x ULN or creatinine clearance (CrCl) > 30 ml/min
  • Women must not be pregnant or breast-feeding
  • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days prior to and again within 24 hours of starting lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide; FCBP must also agree to ongoing pregnancy testing; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy; all patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01856192

  Hide Study Locations
Locations
United States, Alaska
Alaska Women's Cancer Care Suspended
Anchorage, Alaska, United States, 99508
Anchorage Oncology Centre Suspended
Anchorage, Alaska, United States, 99508
Katmai Oncology Group Suspended
Anchorage, Alaska, United States, 99508
Providence Alaska Medical Center Suspended
Anchorage, Alaska, United States, 99508
Alaska Breast Care and Surgery LLC Suspended
Anchorage, Alaska, United States, 99508
United States, Arizona
Mayo Clinic in Arizona Suspended
Scottsdale, Arizona, United States, 85259
The University of Arizona Medical Center-University Campus Suspended
Tucson, Arizona, United States, 85724
University of Arizona Cancer Center-North Campus Suspended
Tucson, Arizona, United States, 85719
United States, Arkansas
Veteran's Administration Medical Center Suspended
Little Rock, Arkansas, United States, 72205
United States, California
Kaiser Permanente-Deer Valley Medical Center Suspended
Antioch, California, United States, 94531
Sutter Auburn Faith Hospital Suspended
Auburn, California, United States, 95602
Kaiser Permanente-Baldwin Park Suspended
Baldwin Park, California, United States, 91706
Providence Saint Joseph Medical Center/Disney Family Cancer Center Suspended
Burbank, California, United States, 91505
Kaiser Permanente-Irvine Suspended
Irvine, California, United States, 92618
Loma Linda University Medical Center Suspended
Loma Linda, California, United States, 92354
Memorial Medical Center Suspended
Modesto, California, United States, 95355
Palo Alto Medical Foundation-Camino Division Suspended
Mountain View, California, United States, 94040
Palo Alto Medical Foundation-Gynecologic Oncology Suspended
Mountain View, California, United States, 94040
Kaiser Permanente-Oakland Suspended
Oakland, California, United States, 94611
UC Irvine Health/Chao Family Comprehensive Cancer Center Suspended
Orange, California, United States, 92868
Palo Alto Medical Foundation Health Care Suspended
Palo Alto, California, United States, 94301
Stanford Cancer Institute Suspended
Palo Alto, California, United States, 94304
Kaiser Permanente - Panorama City Suspended
Panorama City, California, United States, 91402
Kaiser Permanente-Richmond Suspended
Richmond, California, United States, 94801
Kaiser Permanente-South Sacramento Suspended
Sacramento, California, United States, 95823
Sutter General Hospital Suspended
Sacramento, California, United States, 95816
Kaiser Permanente - Sacramento Suspended
Sacramento, California, United States, 95825
Kaiser Permanente-San Diego Mission Suspended
San Diego, California, United States, 92108
Kaiser Permanente-San Diego Zion Suspended
San Diego, California, United States, 92120
California Pacific Medical Center-Pacific Campus Suspended
San Francisco, California, United States, 94115
Kaiser Permanente-San Francisco Suspended
San Francisco, California, United States, 94115
Kaiser Permanente-Santa Teresa-San Jose Suspended
San Jose, California, United States, 95119
Stanford Cancer Center South Bay Suspended
San Jose, California, United States, 95124
Kaiser Permanente-San Marcos Suspended
San Marcos, California, United States, 92069
Kaiser Permanente-San Rafael Suspended
San Rafael, California, United States, 94903
Kaiser Permanente Medical Center - Santa Clara Suspended
Santa Clara, California, United States, 95051
Palo Alto Medical Foundation-Santa Cruz Suspended
Santa Cruz, California, United States, 95065
Kaiser Permanente-Santa Rosa Suspended
Santa Rosa, California, United States, 95403
Sutter Pacific Medical Foundation Suspended
Santa Rosa, California, United States, 95403
Kaiser Permanente-South San Francisco Suspended
South San Francisco, California, United States, 94080
Palo Alto Medical Foundation-Sunnyvale Suspended
Sunnyvale, California, United States, 94086
Kaiser Permanente-Walnut Creek Suspended
Walnut Creek, California, United States, 94596
Kaiser Permanente Suspended
Woodland Hills, California, United States, 91367
United States, Colorado
Rocky Mountain Cancer Centers-Aurora Suspended
Aurora, Colorado, United States, 80012
The Medical Center of Aurora Suspended
Aurora, Colorado, United States, 80012
Boulder Community Hospital Suspended
Boulder, Colorado, United States, 80301
Penrose-Saint Francis Healthcare Suspended
Colorado Springs, Colorado, United States, 80907
Rocky Mountain Cancer Centers-Penrose Suspended
Colorado Springs, Colorado, United States, 80907
Colorado Cancer Research Program NCORP Recruiting
Denver, Colorado, United States, 80222
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Porter Adventist Hospital Suspended
Denver, Colorado, United States, 80210
Colorado Blood Cancer Institute Suspended
Denver, Colorado, United States, 80218
Kaiser Permanente-Franklin Suspended
Denver, Colorado, United States, 80205
Rocky Mountain Cancer Centers-Midtown Suspended
Denver, Colorado, United States, 80218
SCL Health Saint Joseph Hospital Suspended
Denver, Colorado, United States, 80218
Rocky Mountain Cancer Centers-Rose Suspended
Denver, Colorado, United States, 80220
Rose Medical Center Suspended
Denver, Colorado, United States, 80220
Presbyterian - Saint Lukes Medical Center - Health One Suspended
Denver, Colorado, United States, 80218
Mercy Medical Center Suspended
Durango, Colorado, United States, 81301
Comprehensive Cancer Care and Research Institute of Colorado LLC Suspended
Englewood, Colorado, United States, 80113
Swedish Medical Center Suspended
Englewood, Colorado, United States, 80113
Mountain Blue Cancer Care Center Suspended
Golden, Colorado, United States, 80401
North Colorado Medical Center Suspended
Greeley, Colorado, United States, 80631
Rocky Mountain Cancer Centers-Greenwood Village Suspended
Greenwood Village, Colorado, United States, 80111
Kaiser Permanente-Rock Creek Suspended
Lafayette, Colorado, United States, 80026
Rocky Mountain Cancer Centers-Lakewood Suspended
Lakewood, Colorado, United States, 80228
Saint Anthony Hospital Suspended
Lakewood, Colorado, United States, 80228
Rocky Mountain Cancer Centers-Littleton Suspended
Littleton, Colorado, United States, 80120
Littleton Adventist Hospital Suspended
Littleton, Colorado, United States, 80122
Rocky Mountain Cancer Centers-Sky Ridge Suspended
Lone Tree, Colorado, United States, 80124
Sky Ridge Medical Center Suspended
Lone Tree, Colorado, United States, 80124
Longmont United Hospital Suspended
Longmont, Colorado, United States, 80501
Rocky Mountain Cancer Centers-Longmont Suspended
Longmont, Colorado, United States, 80501
McKee Medical Center Suspended
Loveland, Colorado, United States, 80539
Parker Adventist Hospital Suspended
Parker, Colorado, United States, 80138
Rocky Mountain Cancer Centers-Parker Suspended
Parker, Colorado, United States, 80138
Saint Mary Corwin Medical Center Suspended
Pueblo, Colorado, United States, 81004
Rocky Mountain Cancer Centers-Thornton Suspended
Thornton, Colorado, United States, 80260
SCL Health Lutheran Medical Center Suspended
Wheat Ridge, Colorado, United States, 80033
United States, Connecticut
Smilow Cancer Hospital Care Center at Saint Francis Suspended
Hartford, Connecticut, United States, 06105
The Hospital of Central Connecticut Suspended
New Britain, Connecticut, United States, 06050
Yale University Suspended
New Haven, Connecticut, United States, 06520
United States, Delaware
Bayhealth Medical Center at Kent General Active, not recruiting
Dover, Delaware, United States, 19901
Beebe Medical Center Active, not recruiting
Lewes, Delaware, United States, 19958
Delaware Clinical and Laboratory Physicians PA Active, not recruiting
Newark, Delaware, United States, 19713
Christiana Care Health System-Christiana Hospital Active, not recruiting
Newark, Delaware, United States, 19718
Medical Oncology Hematology Consultants PA Active, not recruiting
Newark, Delaware, United States, 19713
Regional Hematology and Oncology PA Active, not recruiting
Newark, Delaware, United States, 19713
Helen F Graham Cancer Center Active, not recruiting
Newark, Delaware, United States, 19713
Beebe Health Campus Active, not recruiting
Rehoboth Beach, Delaware, United States, 19971
Nanticoke Memorial Hospital Active, not recruiting
Seaford, Delaware, United States, 19973
United States, District of Columbia
Sibley Memorial Hospital Suspended
Washington, District of Columbia, United States, 20016
United States, Florida
The Watson Clinic Recruiting
Lakeland, Florida, United States, 33805
Contact: Galina Vugman    863-603-4720    gvugman@watsonclinic.com   
Principal Investigator: Galina Vugman         
UF Cancer Center at Orlando Health Suspended
Orlando, Florida, United States, 32806
United States, Georgia
Emory University/Winship Cancer Institute Suspended
Atlanta, Georgia, United States, 30322
Gwinnett Medical Center Suspended
Lawrenceville, Georgia, United States, 30045
Medical Center of Central Georgia Suspended
Macon, Georgia, United States, 31201
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Suspended
Savannah, Georgia, United States, 31405
United States, Hawaii
Straub Clinic and Hospital Suspended
Honolulu, Hawaii, United States, 96813
Oncare Hawaii Inc-POB II Suspended
Honolulu, Hawaii, United States, 96813
University of Hawaii Cancer Center Suspended
Honolulu, Hawaii, United States, 96813
OnCare Hawaii-Kuakini Suspended
Honolulu, Hawaii, United States, 96817
The Cancer Center of Hawaii-Liliha Suspended
Honolulu, Hawaii, United States, 96817
Kaiser Permanente Moanalua Medical Center Suspended
Honolulu, Hawaii, United States, 96819
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Christopher M. Reynolds    734-712-4673    christopher_reynolds@ihacares.com   
Principal Investigator: Christopher M. Reynolds         
Saint Luke's Mountain States Tumor Institute Suspended
Boise, Idaho, United States, 83712
Saint Luke's Mountain States Tumor Institute - Fruitland Suspended
Fruitland, Idaho, United States, 83619
Saint Luke's Mountain States Tumor Institute - Meridian Suspended
Meridian, Idaho, United States, 83642
Saint Luke's Mountain States Tumor Institute - Nampa Suspended
Nampa, Idaho, United States, 83686
Kootenai Cancer Center Suspended
Post Falls, Idaho, United States, 83854
Saint Luke's Mountain States Tumor Institute-Twin Falls Suspended
Twin Falls, Idaho, United States, 83301
United States, Illinois
Illinois CancerCare-Bloomington Suspended
Bloomington, Illinois, United States, 61704
Illinois CancerCare-Canton Suspended
Canton, Illinois, United States, 61520
Illinois CancerCare-Carthage Suspended
Carthage, Illinois, United States, 62321
Northwestern University Suspended
Chicago, Illinois, United States, 60611
Presence Saint Joseph Hospital-Chicago Suspended
Chicago, Illinois, United States, 60657
Carle on Vermilion Active, not recruiting
Danville, Illinois, United States, 61832
Cancer Care Center of Decatur Suspended
Decatur, Illinois, United States, 62526
Decatur Memorial Hospital Suspended
Decatur, Illinois, United States, 62526
Heartland Cancer Research NCORP Terminated
Decatur, Illinois, United States, 62526
Carle Physician Group-Effingham Active, not recruiting
Effingham, Illinois, United States, 62401
Crossroads Cancer Center Suspended
Effingham, Illinois, United States, 62401
AMITA Health Alexian Brothers Medical Center Suspended
Elk Grove Village, Illinois, United States, 60007
Illinois CancerCare-Eureka Suspended
Eureka, Illinois, United States, 61530
Illinois CancerCare-Galesburg Cottage Plaza Office Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Galesburg Suspended
Galesburg, Illinois, United States, 61401
Northwestern Medicine Cancer Center Delnor Suspended
Geneva, Illinois, United States, 60134
Ingalls Memorial Hospital Suspended
Harvey, Illinois, United States, 60426
Hinsdale Hematology Oncology Associates Incorporated Suspended
Hinsdale, Illinois, United States, 60521
Joliet Oncology-Hematology Associates Limited Suspended
Joliet, Illinois, United States, 60435
Illinois CancerCare-Kewanee Clinic Suspended
Kewanee, Illinois, United States, 61443
Illinois CancerCare-Macomb Suspended
Macomb, Illinois, United States, 61455
Carle Physician Group-Mattoon/Charleston Active, not recruiting
Mattoon, Illinois, United States, 61938
Trinity Medical Center Suspended
Moline, Illinois, United States, 61265
Illinois CancerCare-Monmouth Terminated
Monmouth, Illinois, United States, 61462
Illinois Cancer Specialists-Niles Suspended
Niles, Illinois, United States, 60714
Illinois CancerCare-Ottawa Clinic Suspended
Ottawa, Illinois, United States, 61350
Illinois CancerCare-Pekin Suspended
Pekin, Illinois, United States, 61554
Illinois CancerCare-Peoria Suspended
Peoria, Illinois, United States, 61615
Illinois CancerCare-Peru Suspended
Peru, Illinois, United States, 61354
Illinois CancerCare-Princeton Suspended
Princeton, Illinois, United States, 61356
Swedish American Hospital Withdrawn
Rockford, Illinois, United States, 61104
SwedishAmerican Regional Cancer Center/ACT Suspended
Rockford, Illinois, United States, 61114
Central Illinois Hematology Oncology Center Suspended
Springfield, Illinois, United States, 62702
Southern Illinois University School of Medicine Suspended
Springfield, Illinois, United States, 62702
Springfield Clinic Suspended
Springfield, Illinois, United States, 62703
Memorial Medical Center Suspended
Springfield, Illinois, United States, 62781
Cancer Care Specialists of Illinois-Swansea Suspended
Swansea, Illinois, United States, 62226
Carle Cancer Center Active, not recruiting
Urbana, Illinois, United States, 61801
The Carle Foundation Hospital Active, not recruiting
Urbana, Illinois, United States, 61801
Northwestern Medicine Cancer Center Warrenville Suspended
Warrenville, Illinois, United States, 60555
United States, Indiana
Elkhart Clinic Terminated
Elkhart, Indiana, United States, 46514-2098
Michiana Hematology Oncology PC-Elkhart Terminated
Elkhart, Indiana, United States, 46514
Elkhart General Hospital Terminated
Elkhart, Indiana, United States, 46515
Indiana University/Melvin and Bren Simon Cancer Center Active, not recruiting
Indianapolis, Indiana, United States, 46202
IU Health Central Indiana Cancer Centers-East Active, not recruiting
Indianapolis, Indiana, United States, 46219
Community Howard Regional Health Terminated
Kokomo, Indiana, United States, 46904
IU Health La Porte Hospital Terminated
La Porte, Indiana, United States, 46350
IU Health Arnett Cancer Care Active, not recruiting
Lafayette, Indiana, United States, 47904
Premier Oncology Hematology Associates Active, not recruiting
Merrillville, Indiana, United States, 46410
Michiana Hematology Oncology PC-Mishawaka Suspended
Mishawaka, Indiana, United States, 46545
Saint Joseph Regional Medical Center-Mishawaka Suspended
Mishawaka, Indiana, United States, 46545
IU Health Ball Memorial Hospital Suspended
Muncie, Indiana, United States, 47303
Michiana Hematology Oncology PC-Plymouth Terminated
Plymouth, Indiana, United States, 46563
Reid Hospital and Health Care Services Suspended
Richmond, Indiana, United States, 47374
Michiana Hematology Oncology PC-South Bend Suspended
South Bend, Indiana, United States, 46601
Northern Indiana Cancer Research Consortium Recruiting
South Bend, Indiana, United States, 46628
Contact: Jose A. Bufill    574-237-1328      
Principal Investigator: Jose A. Bufill         
Michiana Hematology Oncology PC-Westville Terminated
Westville, Indiana, United States, 46391
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center Suspended
Ames, Iowa, United States, 50010
Oncology Associates at Mercy Medical Center Suspended
Cedar Rapids, Iowa, United States, 52403
Medical Oncology and Hematology Associates-West Des Moines Suspended
Clive, Iowa, United States, 50325
Mercy Cancer Center-West Lakes Suspended
Clive, Iowa, United States, 50325
Iowa-Wide Oncology Research Coalition NCORP Active, not recruiting
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates-Des Moines Suspended
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates-Laurel Suspended
Des Moines, Iowa, United States, 50314
Mercy Medical Center - Des Moines Suspended
Des Moines, Iowa, United States, 50314
Mercy Medical Center - North Iowa Suspended
Mason City, Iowa, United States, 50401
Ottumwa Regional Health Center Suspended
Ottumwa, Iowa, United States, 52501
Siouxland Regional Cancer Center Suspended
Sioux City, Iowa, United States, 51101
Covenant Medical Center Active, not recruiting
Waterloo, Iowa, United States, 50702
Mercy Medical Center-West Lakes Suspended
West Des Moines, Iowa, United States, 50266
United States, Kansas
Lawrence Memorial Hospital Recruiting
Lawrence, Kansas, United States, 66044
Contact: Shaker R. Dakhil    316-262-4467    shaker.dakhil@cancercenterofkansas.com   
Principal Investigator: Shaker R. Dakhil         
Wesley Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467    shaker.dakhil@cancercenterofkansas.com   
Principal Investigator: Shaker R. Dakhil         
United States, Kentucky
Flaget Memorial Hospital Suspended
Bardstown, Kentucky, United States, 40004
Jewish Hospital Suspended
Louisville, Kentucky, United States, 40202
Jewish Hospital Medical Center Northeast Suspended
Louisville, Kentucky, United States, 40245
United States, Louisiana
Ochsner Health Center-Summa Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
Ochsner Medical Center Kenner Recruiting
Kenner, Louisiana, United States, 70065
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
University Health-Conway Recruiting
Monroe, Louisiana, United States, 71202
Contact: Richard P. Mansour    318-813-1412    rmanso@lsuhsc.edu   
Principal Investigator: Richard P. Mansour         
Ochsner Medical Center Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
Louisiana State University Health Sciences Center Shreveport Recruiting
Shreveport, Louisiana, United States, 71103
Contact: Richard P. Mansour    318-813-1412    rmanso@lsuhsc.edu   
Principal Investigator: Richard P. Mansour         
United States, Maine
Harold Alfond Center for Cancer Care Suspended
Augusta, Maine, United States, 04330
Eastern Maine Medical Center Suspended
Bangor, Maine, United States, 04401
United States, Maryland
Greater Baltimore Medical Center Suspended
Baltimore, Maryland, United States, 21204
Johns Hopkins University/Sidney Kimmel Cancer Center Suspended
Baltimore, Maryland, United States, 21287
Union Hospital of Cecil County Active, not recruiting
Elkton MD, Maryland, United States, 21921
Peninsula Regional Medical Center Suspended
Salisbury, Maryland, United States, 21801
United States, Massachusetts
Tufts Medical Center Suspended
Boston, Massachusetts, United States, 02111
Boston Medical Center Suspended
Boston, Massachusetts, United States, 02118
Baystate Medical Center Suspended
Springfield, Massachusetts, United States, 01199
University of Massachusetts Medical School Suspended
Worcester, Massachusetts, United States, 01655
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Christopher M. Reynolds    734-712-4673    christopher_reynolds@ihacares.com   
Principal Investigator: Christopher M. Reynolds         
University of Michigan Comprehensive Cancer Center Suspended
Ann Arbor, Michigan, United States, 48109
Bronson Battle Creek Suspended
Battle Creek, Michigan, United States, 49017
Beaumont Hospital-Dearborn Recruiting
Dearborn, Michigan, United States, 48124
Contact: Christopher M. Reynolds    734-712-4673    christopher_reynolds@ihacares.com   
Principal Investigator: Christopher M. Reynolds         
Wayne State University/Karmanos Cancer Institute Suspended
Detroit, Michigan, United States, 48201
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Christopher M. Reynolds    734-712-4673    christopher_reynolds@ihacares.com   
Principal Investigator: Christopher M. Reynolds         
Green Bay Oncology - Escanaba Active, not recruiting
Escanaba, Michigan, United States, 49829
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Christopher M. Reynolds    734-712-4673    christopher_reynolds@ihacares.com   
Principal Investigator: Christopher M. Reynolds         
Mercy Health Saint Mary's Suspended
Grand Rapids, Michigan, United States, 49503
Spectrum Health at Butterworth Campus Suspended
Grand Rapids, Michigan, United States, 49503
Green Bay Oncology - Iron Mountain Withdrawn
Iron Mountain, Michigan, United States, 49801
Allegiance Health Recruiting
Jackson, Michigan, United States, 49201
Contact: Christopher M. Reynolds    734-712-4673    christopher_reynolds@ihacares.com   
Principal Investigator: Christopher M. Reynolds         
West Michigan Cancer Center Suspended
Kalamazoo, Michigan, United States, 49007
Saint Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Christopher M. Reynolds    734-712-4673    christopher_reynolds@ihacares.com   
Principal Investigator: Christopher M. Reynolds         
Mercy Health Mercy Campus Suspended
Muskegon, Michigan, United States, 49444
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341
Contact: Christopher M. Reynolds    734-712-4673    christopher_reynolds@ihacares.com   
Principal Investigator: Christopher M. Reynolds         
Saint Joseph Mercy Port Huron Terminated
Port Huron, Michigan, United States, 48060
Spectrum Health Reed City Hospital Suspended
Reed City, Michigan, United States, 49677
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Christopher M. Reynolds    734-712-4673    christopher_reynolds@ihacares.com   
Principal Investigator: Christopher M. Reynolds         
Marie Yeager Cancer Center Suspended
Saint Joseph, Michigan, United States, 49085
Lakeland Hospital Suspended
St. Joseph, Michigan, United States, 49085
Munson Medical Center Suspended
Traverse City, Michigan, United States, 49684
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Christopher M. Reynolds    734-712-4673    christopher_reynolds@ihacares.com   
Principal Investigator: Christopher M. Reynolds         
United States, Minnesota
Sanford Clinic North-Bemidgi Suspended
Bemidji, Minnesota, United States, 56601
Fairview Ridges Hospital Suspended
Burnsville, Minnesota, United States, 55337
Mercy Hospital Suspended
Coon Rapids, Minnesota, United States, 55433
Saint Luke's Hospital of Duluth Suspended
Duluth, Minnesota, United States, 55805
Essentia Health Cancer Center Suspended
Duluth, Minnesota, United States, 55805
Fairview-Southdale Hospital Suspended
Edina, Minnesota, United States, 55435
Lake Region Healthcare Corporation-Cancer Care Suspended
Fergus Falls, Minnesota, United States, 56537
Unity Hospital Suspended
Fridley, Minnesota, United States, 55432
Hutchinson Area Health Care Suspended
Hutchinson, Minnesota, United States, 55350
Minnesota Oncology Hematology PA-Maplewood Suspended
Maplewood, Minnesota, United States, 55109
Saint John's Hospital - Healtheast Suspended
Maplewood, Minnesota, United States, 55109
Abbott-Northwestern Hospital Suspended
Minneapolis, Minnesota, United States, 55407
Hennepin County Medical Center Suspended
Minneapolis, Minnesota, United States, 55415
Health Partners Inc Suspended
Minneapolis, Minnesota, United States, 55454
North Memorial Medical Health Center Suspended
Robbinsdale, Minnesota, United States, 55422
Mayo Clinic Suspended
Rochester, Minnesota, United States, 55905
Coborn Cancer Center at Saint Cloud Hospital Suspended
Saint Cloud, Minnesota, United States, 56303
Metro Minnesota Community Oncology Research Consortium Terminated
Saint Louis Park, Minnesota, United States, 55416
Park Nicollet Clinic - Saint Louis Park Suspended
Saint Louis Park, Minnesota, United States, 55416
Regions Hospital Suspended
Saint Paul, Minnesota, United States, 55101
United Hospital Suspended
Saint Paul, Minnesota, United States, 55102
Saint Francis Regional Medical Center Suspended
Shakopee, Minnesota, United States, 55379
Lakeview Hospital Suspended
Stillwater, Minnesota, United States, 55082
Ridgeview Medical Center Suspended
Waconia, Minnesota, United States, 55387
Rice Memorial Hospital Suspended
Willmar, Minnesota, United States, 56201
Minnesota Oncology and Hematology PA-Woodbury Suspended
Woodbury, Minnesota, United States, 55125
United States, Mississippi
University of Mississippi Medical Center Suspended
Jackson, Mississippi, United States, 39216
United States, Missouri
Central Care Cancer Center-Carrie J Babb Cancer Center Suspended
Bolivar, Missouri, United States, 65613
Saint Francis Medical Center Suspended
Cape Girardeau, Missouri, United States, 63703
Southeast Cancer Center Suspended
Cape Girardeau, Missouri, United States, 63703
Saint Luke's Hospital Suspended
Chesterfield, Missouri, United States, 63017
Capital Region Medical Center-Goldschmidt Cancer Center Suspended
Jefferson City, Missouri, United States, 65109
Saint Luke's Hospital of Kansas City Suspended
Kansas City, Missouri, United States, 64111
Phelps County Regional Medical Center Suspended
Rolla, Missouri, United States, 65401
Saint John's Clinic-Rolla-Cancer and Hematology Suspended
Rolla, Missouri, United States, 65401
Missouri Baptist Medical Center Suspended
Saint Louis, Missouri, United States, 63131
Saint Louis Cancer and Breast Institute-South City Suspended
Saint Louis, Missouri, United States, 63109
Mercy Hospital Saint Louis Suspended
Saint Louis, Missouri, United States, 63141
Mercy Hospital Springfield Suspended
Springfield, Missouri, United States, 65804
CoxHealth South Hospital Suspended
Springfield, Missouri, United States, 65807
United States, Montana
Billings Clinic Cancer Center Suspended
Billings, Montana, United States, 59101
Bozeman Deaconess Hospital Suspended
Bozeman, Montana, United States, 59715
Saint James Community Hospital and Cancer Treatment Center Suspended
Butte, Montana, United States, 59701
Benefis Healthcare- Sletten Cancer Institute Suspended
Great Falls, Montana, United States, 59405
Kalispell Regional Medical Center Suspended
Kalispell, Montana, United States, 59901
Community Medical Hospital Suspended
Missoula, Montana, United States, 59801
Saint Patrick Hospital - Community Hospital Suspended
Missoula, Montana, United States, 59802
United States, Nebraska
CHI Health Saint Francis Suspended
Grand Island, Nebraska, United States, 68803
CHI Health Good Samaritan Suspended
Kearney, Nebraska, United States, 68847
Nebraska Cancer Research Center Suspended
Lincoln, Nebraska, United States, 68510
University of Nebraska Medical Center Suspended
Omaha, Nebraska, United States, 68198
United States, Nevada
University Medical Center of Southern Nevada Suspended
Las Vegas, Nevada, United States, 89102
Nevada Cancer Research Foundation CCOP Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
Cancer and Blood Specialists-Fort Apache Suspended
Las Vegas, Nevada, United States, 89148
United States, New Hampshire
New Hampshire Oncology Hematology PA-Concord Suspended
Concord, New Hampshire, United States, 03301
Wentworth-Douglass Hospital Suspended
Dover, New Hampshire, United States, 03820
New Hampshire Oncology Hematology PA-Hooksett Suspended
Hooksett, New Hampshire, United States, 03106
LRGHealthcare-Lakes Region General Hospital Suspended
Laconia, New Hampshire, United States, 03246
Dartmouth Hitchcock Medical Center Suspended
Lebanon, New Hampshire, United States, 03756
United States, New Jersey
Cooper Hospital University Medical Center Active, not recruiting
Camden, New Jersey, United States, 08103
Englewood Hospital and Medical Center Suspended
Englewood, New Jersey, United States, 07631
Saint Barnabas Medical Center Recruiting
Livingston, New Jersey, United States, 07039
Contact: Miguel A. Conde    973-322-2470    mconde@barnabashealth.org   
Principal Investigator: Miguel A. Conde         
Virtua Memorial Suspended
Mount Holly, New Jersey, United States, 08060
The Valley Hospital-Luckow Pavilion Suspended
Paramus, New Jersey, United States, 07652
Valley Hospital Suspended
Ridgewood, New Jersey, United States, 07450
Inspira Medical Center Vineland Suspended
Vineland, New Jersey, United States, 08360
Valley Health System-Hematology/Oncology Suspended
Westwood, New Jersey, United States, 07675
Inspira Medical Center Woodbury Suspended
Woodbury, New Jersey, United States, 08096
United States, New Mexico
University of New Mexico Cancer Center Suspended
Albuquerque, New Mexico, United States, 87102
Presbyterian Kaseman Hospital Suspended
Albuquerque, New Mexico, United States, 87110
Memorial Medical Center - Las Cruces Suspended
Las Cruces, New Mexico, United States, 88011
United States, New York
Montefiore Medical Center-Einstein Campus Suspended
Bronx, New York, United States, 10461
Montefiore Medical Center-Weiler Hospital Suspended
Bronx, New York, United States, 10461
Montefiore Medical Center - Moses Campus Suspended
Bronx, New York, United States, 10467-2490
Kings County Hospital Active, not recruiting
Brooklyn, New York, United States, 11203
State University of New York Downstate Medical Center Active, not recruiting
Brooklyn, New York, United States, 11203
Roswell Park Cancer Institute Suspended
Buffalo, New York, United States, 14263
Hematology Oncology Associates of Central New York-East Syracuse Active, not recruiting
East Syracuse, New York, United States, 13057
Laura and Isaac Perlmutter Cancer Center at NYU Langone Suspended
New York, New York, United States, 10016
Columbia University/Herbert Irving Cancer Center Suspended
New York, New York, United States, 10032
Champlain Valley Physicians Hospital Medical Center Suspended
Plattsburgh, New York, United States, 12901
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Jonathan W. Friedberg    585-275-5830    jonathan_friedberg@urmc.rochester.edu   
Principal Investigator: Jonathan W. Friedberg         
State University of New York Upstate Medical University Suspended
Syracuse, New York, United States, 13210
United States, North Carolina
Randolph Hospital Suspended
Asheboro, North Carolina, United States, 27203
UNC Lineberger Comprehensive Cancer Center Suspended
Chapel Hill, North Carolina, United States, 27599
Southeastern Medical Oncology Center-Clinton Suspended
Clinton, North Carolina, United States, 28328
Southeastern Medical Oncology Center-Goldsboro Suspended
Goldsboro, North Carolina, United States, 27534
Wayne Memorial Hospital Suspended
Goldsboro, North Carolina, United States, 27534
Cone Health Cancer Center Suspended
Greensboro, North Carolina, United States, 27403
Margaret R Pardee Memorial Hospital Recruiting
Hendersonville, North Carolina, United States, 28791
Contact: James E. Radford    828-696-4716    james.radford@pardeehospital.org   
Principal Investigator: James E. Radford         
Southeastern Medical Oncology Center-Jacksonville Suspended
Jacksonville, North Carolina, United States, 28546
Kinston Medical Specialists PA Suspended
Kinston, North Carolina, United States, 28501
Annie Penn Memorial Hospital Suspended
Reidsville, North Carolina, United States, 27320
Iredell Memorial Hospital Active, not recruiting
Statesville, North Carolina, United States, 28677
Marion L Shepard Cancer Center at Vidant Beaufort Hospital Suspended
Washington, North Carolina, United States, 27889
Southeastern Medical Oncology Center-Wilson Suspended
Wilson, North Carolina, United States, 27893
Wake Forest University Health Sciences Suspended
Winston-Salem, North Carolina, United States, 27157
United States, North Dakota
Sanford Bismarck Medical Center Suspended
Bismarck, North Dakota, United States, 58501
Roger Maris Cancer Center Suspended
Fargo, North Dakota, United States, 58122
Sanford Clinic North-Fargo Suspended
Fargo, North Dakota, United States, 58122
Sanford Medical Center-Fargo Suspended
Fargo, North Dakota, United States, 58122
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center Suspended
Akron, Ohio, United States, 44304
Akron General Medical Center Recruiting
Akron, Ohio, United States, 44307
Contact: Esther H. Rehmus    330-344-6348      
Principal Investigator: Esther H. Rehmus         
Summa Barberton Hospital Suspended
Barberton, Ohio, United States, 44203
Mercy Medical Center Suspended
Canton, Ohio, United States, 44708
Geaugra Hospital Suspended
Chardon, Ohio, United States, 44024
Good Samaritan Hospital - Cincinnati Suspended
Cincinnati, Ohio, United States, 45220
TriHealth Cancer Institute-Westside Suspended
Cincinnati, Ohio, United States, 45247
TriHealth Cancer Institute-Anderson Suspended
Cincinnati, Ohio, United States, 45255
University of Cincinnati Suspended
Cincinnati, Ohio, United States, 45267
MetroHealth Medical Center Suspended
Cleveland, Ohio, United States, 44109
Case Western Reserve University Suspended
Cleveland, Ohio, United States, 44106
Mount Carmel Health Center West Suspended
Columbus, Ohio, United States, 43222
Ohio State University Comprehensive Cancer Center Suspended
Columbus, Ohio, United States, 43210
Columbus Oncology and Hematology Associates Inc Suspended
Columbus, Ohio, United States, 43214
Riverside Methodist Hospital Suspended
Columbus, Ohio, United States, 43214
The Mark H Zangmeister Center Suspended
Columbus, Ohio, United States, 43219
Columbus NCI Community Oncology Research Program Terminated
Columbus, Ohio, United States, 43215
Good Samaritan Hospital - Dayton Suspended
Dayton, Ohio, United States, 45406
Miami Valley Hospital Suspended
Dayton, Ohio, United States, 45409
Samaritan North Health Center Suspended
Dayton, Ohio, United States, 45415
Mercy Cancer Center-Elyria Suspended
Elyria, Ohio, United States, 44035
Blanchard Valley Hospital Suspended
Findlay, Ohio, United States, 45840
Saint Rita's Medical Center Suspended
Lima, Ohio, United States, 45801
Marietta Memorial Hospital Suspended
Marietta, Ohio, United States, 45750
Toledo Clinic Cancer Centers-Maumee Recruiting
Maumee, Ohio, United States, 43537
Contact: Rex B. Mowat    800-444-3561      
Principal Investigator: Rex B. Mowat         
Ireland Cancer Center Landerbrook Health Center Suspended
Mayfield Heights, Ohio, United States, 44124
Lake University Ireland Cancer Center Suspended
Mentor, Ohio, United States, 44060
Licking Memorial Hospital Suspended
Newark, Ohio, United States, 43055
Ireland Cancer Center at Firelands Regional Medical Center Suspended
Sandusky, Ohio, United States, 44870
Springfield Regional Cancer Center Suspended
Springfield, Ohio, United States, 45504
Springfield Regional Medical Center Suspended
Springfield, Ohio, United States, 45505
Flower Hospital Suspended
Sylvania, Ohio, United States, 43560
University of Toledo Active, not recruiting
Toledo, Ohio, United States, 43614
Toledo Clinic Cancer Centers-Toledo Recruiting
Toledo, Ohio, United States, 43623
Contact: Rex B. Mowat    800-444-3561      
Principal Investigator: Rex B. Mowat         
Saint Ann's Hospital Suspended
Westerville, Ohio, United States, 43081
UH-Seidman Cancer Center at Saint John Medical Center Suspended
Westlake, Ohio, United States, 44145
United States, Oklahoma
University of Oklahoma Health Sciences Center Suspended
Oklahoma City, Oklahoma, United States, 73104
Oklahoma Cancer Specialists and Research Institute-Tulsa Suspended
Tulsa, Oklahoma, United States, 74146
United States, Oregon
Bay Area Hospital Suspended
Coos Bay, Oregon, United States, 97420
Providence Newberg Medical Center Suspended
Newberg, Oregon, United States, 97132
Providence Willamette Falls Medical Center Suspended
Oregon City, Oregon, United States, 97045
Providence Portland Medical Center Suspended
Portland, Oregon, United States, 97213
Providence Saint Vincent Medical Center Suspended
Portland, Oregon, United States, 97225
United States, Pennsylvania
Lehigh Valley Hospital-Cedar Crest Recruiting
Allentown, Pennsylvania, United States, 18103
Contact: Eliot L. Friedman    610-402-2273    eliot_l.friedman@lvh.com   
Principal Investigator: Eliot L. Friedman         
Saint Luke's University Hospital-Bethlehem Campus Suspended
Bethlehem, Pennsylvania, United States, 18015
Bryn Mawr Hospital Active, not recruiting
Bryn Mawr, Pennsylvania, United States, 19010
Geisinger Medical Center Active, not recruiting
Danville, Pennsylvania, United States, 17822
Doylestown Hospital Suspended
Doylestown, Pennsylvania, United States, 18901
Delaware County Memorial Hospital Suspended
Drexel Hill, Pennsylvania, United States, 19026
Ephrata Cancer Center Recruiting
Ephrata, Pennsylvania, United States, 17522
Contact: Amir Tabatabai    877-441-7957    atabatabai@wellspan.org   
Principal Investigator: Amir Tabatabai         
Ephrata Community Hospital Suspended
Ephrata, Pennsylvania, United States, 17522
Adams Cancer Center Recruiting
Gettysburg, Pennsylvania, United States, 17325
Contact: Amir Tabatabai    877-441-7957    atabatabai@wellspan.org   
Principal Investigator: Amir Tabatabai         
Cherry Tree Cancer Center Recruiting
Hanover, Pennsylvania, United States, 17331
Contact: Amir Tabatabai    877-441-7957    atabatabai@wellspan.org   
Principal Investigator: Amir Tabatabai         
Geisinger Medical Center-Cancer Center Hazleton Suspended
Hazleton, Pennsylvania, United States, 18201
Penn State Milton S Hershey Medical Center Suspended
Hershey, Pennsylvania, United States, 17033-0850
Paoli Memorial Hospital Active, not recruiting
Paoli, Pennsylvania, United States, 19301
University of Pennsylvania/Abramson Cancer Center Suspended
Philadelphia, Pennsylvania, United States, 19104
Thomas Jefferson University Hospital Suspended
Philadelphia, Pennsylvania, United States, 19107
Fox Chase Cancer Center Suspended
Philadelphia, Pennsylvania, United States, 19111
Temple University Hospital Active, not recruiting
Philadelphia, Pennsylvania, United States, 19140
Pottstown Memorial Medical Center Suspended
Pottstown, Pennsylvania, United States, 19464
Hematology and Oncology Associates of North East Pennsylvania Suspended
Scranton, Pennsylvania, United States, 18508
Grand View Hospital Withdrawn
Sellersville, Pennsylvania, United States, 18960
Mount Nittany Medical Center Suspended
State College, Pennsylvania, United States, 16803
Chester County Hospital Suspended
West Chester, Pennsylvania, United States, 19380
Reading Hospital Suspended
West Reading, Pennsylvania, United States, 19611
Geisinger Wyoming Valley/Henry Cancer Center Suspended
Wilkes-Barre, Pennsylvania, United States, 18711
Lankenau Medical Center Active, not recruiting
Wynnewood, Pennsylvania, United States, 19096
WellSpan Health-York Hospital Recruiting
York, Pennsylvania, United States, 17403
Contact: Amir Tabatabai    877-441-7957    atabatabai@wellspan.org   
Principal Investigator: Amir Tabatabai         
United States, South Carolina
Greenville Health System Cancer Institute-Easley Suspended
Easley, South Carolina, United States, 29640
Greenville Health System Cancer Institute-Butternut Suspended
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Faris Suspended
Greenville, South Carolina, United States, 29605
Greenville Memorial Hospital Suspended
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Eastside Suspended
Greenville, South Carolina, United States, 29615
Greenville Health System Cancer Institute-Andrews Suspended
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Greer Suspended
Greer, South Carolina, United States, 29650
Greenville Health System Cancer Institute-Seneca Suspended
Seneca, South Carolina, United States, 29672
Greenville Health System Cancer Institute-Spartanburg Suspended
Spartanburg, South Carolina, United States, 29307
United States, South Dakota
Rapid City Regional Hospital Suspended
Rapid City, South Dakota, United States, 57701
Sanford Cancer Center-Oncology Clinic Suspended
Sioux Falls, South Dakota, United States, 57104
Avera Cancer Institute Recruiting
Sioux Falls, South Dakota, United States, 57105
Contact: Amy K. Krie    888-634-7268    oncregulatory@avera.org   
Principal Investigator: Amy K. Krie         
Sanford USD Medical Center - Sioux Falls Suspended
Sioux Falls, South Dakota, United States, 57117-5134
United States, Tennessee
Vanderbilt University/Ingram Cancer Center Suspended
Nashville, Tennessee, United States, 37232
United States, Texas
University Medical Center Brackenridge Suspended
Austin, Texas, United States, 78701
Parkland Memorial Hospital Suspended
Dallas, Texas, United States, 75235
UT Southwestern/Simmons Cancer Center-Dallas Suspended
Dallas, Texas, United States, 75390
Brooke Army Medical Center Suspended
Fort Sam Houston, Texas, United States, 78234
Covenant Medical Center-Lakeside Suspended
Lubbock, Texas, United States, 79410
Texas Tech University Health Sciences Center Suspended
Lubbock, Texas, United States, 79430
University of Texas Health Science Center at San Antonio Suspended
San Antonio, Texas, United States, 78229
United States, Virginia
University of Virginia Cancer Center Suspended
Charlottesville, Virginia, United States, 22908
Augusta Health Cancer Center Recruiting
Fishersville, Virginia, United States, 22939
Contact: Zuhair Ghanem    540-245-7106      
Principal Investigator: Zuhair Ghanem         
Memorial Hospital Of Martinsville Suspended
Martinsville, Virginia, United States, 24115
United States, Washington
Swedish Medical Center-Edmonds Suspended
Edmonds, Washington, United States, 98026
PeaceHealth Saint John Medical Center Suspended
Longview, Washington, United States, 98632
Swedish Medical Center-Ballard Campus Suspended
Seattle, Washington, United States, 98107
Swedish Medical Center-First Hill Suspended
Seattle, Washington, United States, 98122-4307
PeaceHealth Southwest Medical Center Suspended
Vancouver, Washington, United States, 98664
United States, West Virginia
West Virginia University Charleston Suspended
Charleston, West Virginia, United States, 25304
United States, Wisconsin
Langlade Hospital and Cancer Center Suspended
Antigo, Wisconsin, United States, 54409
Fox Valley Hematology and Oncology SC-Appleton Suspended
Appleton, Wisconsin, United States, 54913
Aurora Cancer Care-Burlington Suspended
Burlington, Wisconsin, United States, 53105
Marshfield Clinic Cancer Center at Sacred Heart Suspended
Eau Claire, Wisconsin, United States, 54701
Sacred Heart Hospital Suspended
Eau Claire, Wisconsin, United States, 54701
Aurora Cancer Care-Southern Lakes Suspended
Elkhorn, Wisconsin, United States, 53121
Aurora Cancer Care-Grafton Suspended
Grafton, Wisconsin, United States, 53024
Green Bay Oncology at Saint Vincent Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54301-3526
Aurora BayCare Medical Center Suspended
Green Bay, Wisconsin, United States, 54311-6519
Saint Vincent Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54301
Green Bay Oncology Limited at Saint Mary's Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54303
Saint Mary's Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54303
Bellin Memorial Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54301
UW Cancer Center Johnson Creek Suspended
Johnson Creek, Wisconsin, United States, 53038
Aurora Cancer Care-Kenosha South Active, not recruiting
Kenosha, Wisconsin, United States, 53142
Gundersen Lutheran Medical Center Suspended
La Crosse, Wisconsin, United States, 54601
University of Wisconsin Hospital and Clinics Suspended
Madison, Wisconsin, United States, 53792
Dean Hematology and Oncology Clinic Active, not recruiting
Madison, Wisconsin, United States, 53717
Bay Area Medical Center Withdrawn
Marinette, Wisconsin, United States, 54143
Vince Lombardi Cancer Clinic-Marinette Suspended
Marinette, Wisconsin, United States, 54143
Marshfield Clinic Suspended
Marshfield, Wisconsin, United States, 54449
Saint Joseph's Hospital Suspended
Marshfield, Wisconsin, United States, 54449
Aurora Advanced Healthcare Inc-Menomonee Falls Suspended
Menomonee Falls, Wisconsin, United States, 53051
Aurora Saint Luke's Medical Center Suspended
Milwaukee, Wisconsin, United States, 53215
Aurora Cancer Care-Milwaukee South Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Rubina Qamar    888-709-2080      
Principal Investigator: Rubina Qamar         
Aurora Cancer Care-Milwaukee Suspended
Milwaukee, Wisconsin, United States, 53209
Froedtert and the Medical College of Wisconsin Suspended
Milwaukee, Wisconsin, United States, 53226
Aurora Sinai Medical Center Suspended
Milwaukee, Wisconsin, United States, 53233
Marshfield Clinic-Minocqua Center Suspended
Minocqua, Wisconsin, United States, 54548
Cancer Center of Western Wisconsin Suspended
New Richmond, Wisconsin, United States, 54017
Oconomowoc Memorial Hospital-ProHealth Care Inc Suspended
Oconomowoc, Wisconsin, United States, 53066
Green Bay Oncology - Oconto Falls Active, not recruiting
Oconto Falls, Wisconsin, United States, 54154
Vince Lombardi Cancer Clinic - Oshkosh Suspended
Oshkosh, Wisconsin, United States, 54904
Aurora Cancer Care-Racine Active, not recruiting
Racine, Wisconsin, United States, 53406
Marshfield Clinic at James Beck Cancer Center Suspended
Rhinelander, Wisconsin, United States, 54501
Saint Mary's Hospital Suspended
Rhinelander, Wisconsin, United States, 54501
Lakeview Medical Center-Marshfield Clinic Suspended
Rice Lake, Wisconsin, United States, 54868
Marshfield Clinic-Rice Lake Center Suspended
Rice Lake, Wisconsin, United States, 54868
Vince Lombardi Cancer Clinic-Sheboygan Suspended
Sheboygan, Wisconsin, United States, 53081
Saint Michael's Hospital Suspended
Stevens Point, Wisconsin, United States, 54481
Marshfield Clinic Cancer Care at Saint Michael's Hospital Suspended
Stevens Point, Wisconsin, United States, 54481
Green Bay Oncology - Sturgeon Bay Active, not recruiting
Sturgeon Bay, Wisconsin, United States, 54235
Aurora Medical Center in Summit Suspended
Summit, Wisconsin, United States, 53066
Vince Lombardi Cancer Clinic Suspended
Two Rivers, Wisconsin, United States, 54241
Aurora Cancer Care-Waukesha Suspended
Waukesha, Wisconsin, United States, 53188
UW Cancer Center at ProHealth Care Suspended
Waukesha, Wisconsin, United States, 53188
Waukesha Memorial Hospital Suspended
Waukesha, Wisconsin, United States, 53188
Aspirus Regional Cancer Center Suspended
Wausau, Wisconsin, United States, 54401
Marshfield Clinic-Wausau Center Suspended
Wausau, Wisconsin, United States, 54401
Aurora Cancer Care-Milwaukee West Suspended
Wauwatosa, Wisconsin, United States, 53226
Aurora West Allis Medical Center Suspended
West Allis, Wisconsin, United States, 53227
Diagnostic and Treatment Center Suspended
Weston, Wisconsin, United States, 54476
Marshfield Clinic - Weston Center Suspended
Weston, Wisconsin, United States, 54476
Aspirus UW Cancer Center Suspended
Wisconsin Rapids, Wisconsin, United States, 54494
Marshfield Clinic - Wisconsin Rapids Center Suspended
Wisconsin Rapids, Wisconsin, United States, 54494
Sponsors and Collaborators
National Cancer Institute (NCI)
Investigators
Principal Investigator: Grzegorz Nowakowski ECOG-ACRIN Cancer Research Group
  More Information

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT01856192     History of Changes
Other Study ID Numbers: NCI-2013-00959  NCI-2013-00959  ECOG-E1412  E1412  E1412  U10CA180820  U10CA021115 
Study First Received: May 14, 2013
Last Updated: July 28, 2016
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Lymphoma
Lymphoma, B-Cell
Lymphoma, Large B-Cell, Diffuse
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Lymphoma, Non-Hodgkin
Cyclophosphamide
Thalidomide
Rituximab
Liposomal doxorubicin
Lenalidomide
Doxorubicin
Prednisone
Vincristine
Antibodies
Immunoglobulins
Antibodies, Monoclonal
Cortisone acetate
Cortisone
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on July 28, 2016