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Investigating Variation in Hospital Acute Coronary Syndrome Outcomes

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ClinicalTrials.gov Identifier: NCT01808027
Recruitment Status : Completed
First Posted : March 8, 2013
Last Update Posted : March 8, 2013
Sponsor:
Information provided by (Responsible Party):
Oras Alabas, University of Leeds

Study Description
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Brief Summary:
To investigate the causes of hospital variation in outcomes from acute coronary syndromes in England and develop recommendations for improving patient care.

Condition or disease
Acute Myocardial Infarction

Detailed Description:
Over the last few years the chance of dying from a heart attack in England and Wales has reduced dramatically. Even so, there remain huge differences in mortality between hospitals. For example, up to a third of patients with a heart attack who attend hospitals in England are more likely to die than would be expected. That is, the type of treatment and the risk of death depends upon where a patient lives and which hospital they attend. In part, the variation in death may be due to the services available at the hospital or to factors such as socioeconomic deprivation. It may also relate to other factors such as depression, cardiac rehabilitation and whether patients take their medication after discharge from hospital. Using powerful statistical approaches that include measures of quality of life, we propose to examine data about heart attacks in England and investigate the 'postcode lottery of care'. Our aim, using regional data about heart attacks is to identify and measure the effects of hospital care. This research will identify hospital qualities that promote improved patient care. In doing so, best practice will be highlighted and healthcare policy changed so that all patients will have an equal chance of surviving a heart attack.
Study Design
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Study Type : Observational [Patient Registry]
Actual Enrollment : 5555 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 12 Months
Official Title: Evaluation of the Methods and Management of Acute Coronary Events: 3. Investigating Variation in Hospital Acute Coronary Syndrome Outcomes
Study Start Date : February 2011
Actual Primary Completion Date : February 2013
Actual Study Completion Date : February 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack

Groups and Cohorts
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Group/Cohort
Acute myocardial infarction
patient with suspected acute coronary syndrome (ACS).


Outcome Measures
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Primary Outcome Measures :
  1. delays to treatment [ Time Frame: 12 months ]
    Quantification of hospital attributable effects relating to early and late mortality


Secondary Outcome Measures :
  1. Describing trajectories of quality of life recovery patterns [ Time Frame: 12 month ]
    Describing trajectories of quality of life recovery patterns


Other Outcome Measures:
  1. Develop a risk score and a near-point risk Acute Coronary Syndrome model [ Time Frame: two years ]
    Develop a risk score and a near-point risk Acute Coronary Syndrome model


Biospecimen Retention:   Samples With DNA
Blood

Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Consented patients with acute coronary syndrome were recruited from acute Trusts in England. These hospitals have been selected because of their diverse population demographics, different acute coronary syndrome care pathways and established track record for good data collection. Specifically these hospitals represent both teaching hospitals and community hospitals - but more importantly include a wide range of patient types. Mortality tracked through the UK statistics authority, and primary and secondary endpoints tracked locally and transferred through the secure NHS net to a central database.
Criteria

Inclusion Criteria:

  • Age > 18 years
  • Both sexes
  • Acute admission to the acute Trust with suspected acute coronary syndrome

Exclusion Criteria:

  • Patients at a terminal stage of any illness
  • Those in whom follow up would be inappropriate or impractical
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01808027


Locations
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United Kingdom
University of Leeds
Leeds, West Yorkshire, United Kingdom, LS2 9JT
Sponsors and Collaborators
University of Leeds
Investigators
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Principal Investigator: Chris P Gale, PhD University of Leeds
More Information
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Additional Information:

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Oras Alabas, Dr, University of Leeds
ClinicalTrials.gov Identifier: NCT01808027    
Other Study ID Numbers: 10/H1313/74
First Posted: March 8, 2013    Key Record Dates
Last Update Posted: March 8, 2013
Last Verified: March 2013
Keywords provided by Oras Alabas, University of Leeds:
quality of life drug adherence drug compliance mortality
Additional relevant MeSH terms:
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Myocardial Infarction
Acute Coronary Syndrome
Infarction
Ischemia
Pathologic Processes
 Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases