Comparison Between Methadone and Morphine for Neonatal Opiate Withdrawal (NAS)

• ClinicalTrials.gov Identifier: NCT01804075
• Recruitment Status: Completed
• First Posted: March 5, 2013
• Results First Posted: August 30, 2017
• Last Update Posted: September 28, 2017
• Sponsor: Eastern Maine Medical Center
• Information provided by (Responsible Party): Mark S Brown, MD, Eastern Maine Medical Center

Study Description

Brief Summary:

Hypothesis is that the effectiveness of opiate treatment with morphine will result in shorter duration of opiate medication treatment and fewer infants treated with a second drug.

Condition or disease	Intervention/treatment	Phase
Neonatal Abstinence Syndrome	Drug: Methadone; Drug: Morphine	Phase 4

Detailed Description:

The purpose is to compare treatment of NAS with two different initial medications with primary outcome of (1) reducing the duration of opiate medication treatment and (2) reducing the number of infants treated with a second medication.

Design is a randomized, blinded comparison. The comparison is between methadone and morphine

Research Design:

a. Procedures: NAS scoring is currently done on infants meeting the inclusion criteria. NAS scores are done every 2 hours for 24 hours and then every 4 hours when awake after feeding for the duration of observation and treatment.

i. NAS scores may indicate more than withdrawal. Conditions such as colic (hypercaloric formula, transient lactose intolerance), reflux, diaper irritation, prenatal SSRI exposure, and nicotine withdrawal or baseline irritability may influence the variability of scores. Decisions based on the NAS scores should take into account these factors for the infant.

b. Emergence of symptom, dosing, and initiation of treatment: Withdrawal significant enough to warrant consideration for treatment is defined as 2 NAS scores >8. Once this threshold has been reached and consent obtained, the infant is randomized to treatment arm, stratified for prenatal exposure to methadone or buprenorphine. Twins will be randomized together to the same arm. The treatment arms are either: i. Methadone (1 mg/mL) or morphine (1 mg/mL) administered orally every 4 hours. The following is a dosing guide:

NAS Score Methadone or Morphine 8-12 0.05 mg/kg/dose >13 0.1 mg/kg/dose

1. Maximum dose of methadone or morphine will be 0.2 mg/kg/dose. (NeoFax)
2. Additional doses, 0.05 mg/kg, may be given every 12 hours as needed and added to the next 24 hour's doses divided every 4 hours, until NAS scores are consistently <8 for 48 hours.

3. If the maximum dose of methadone or morphine is reached and if withdrawal is not controlled, the infant will be started on clonazepam (0.005 mg/kg/dose q 12h) per current treatment.

   c. Tapering medications: When the infant has NAS scores consistently <8 for 36 hours: i.The taper will be on a daily basis of 10% of the final maintenance dose. Dosages will be decreased in a measured amount to maintain NAS scores <8. After the last dose, there will be a 24 to 36 hour observation period.

   d.Non-tolerance of tapering: Non-tolerance of tapering is defined as 2 NAS scores >8 during the 12 hour period prior to the next taper dose: i.The tapering should be stopped at the current level. ii.If necessary, an extra dose of methadone or morphine can be given and added to the next day's dose divided into 6 doses. If withdrawal re-emerges after this dose (2 NAS scores >8), then the maintenance dose should be increased back to the last level; an extra dose may be given up to 4 to 5 hours after the previous dose.

   iii. If an extra dose is not given, the wean schedule can be resumed after 24 hours of NAS scores <8; when dosing is resumed, the frequency should be changed to every 4 hours with the same total daily dose.

   e. Holding of doses: Methadone or morphine will be held for poor feeding, respiratory depression, or somnolence at any time in the protocol.

Study Design

• Study Type: Interventional (Clinical Trial)
• Actual Enrollment: 31 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Double (Participant, Care Provider)
• Primary Purpose: Treatment
• Official Title: Evaluation of Efficacy of Methadone Versus Morphine for Treatment of Neonatal Abstinence Syndrome (NAS).
• Study Start Date: January 2011
• Actual Primary Completion Date: October 2012
• Actual Study Completion Date: October 2012

Arms and Interventions

Arm	Intervention/treatment
Active Comparator: methadone; Methadone (1 mg/mL) administered orally every 4 hours. The following is a dosing guide: NAS Score Methadone 8-12 0.05 mg/kg/dose >=13 0.1 mg/kg/dose; Maximum dose of methadone will be 0.2 mg/kg/dose. (NeoFax); Additional doses, 0.05 mg/kg, may be given every 4 hours as needed and added to the next 24 hour's doses divided every 4 hours, until NAS scores are consistently <8 for 48 hours.; If the maximum dose of methadone is reached and if withdrawal is not controlled, the infant will be started on clonazepam (0.005 mg/kg/dose q 12h) per current treatment.	Drug: Methadone; To compare the duration of opiate medication treatment for babies on methadone versus those on morphine.; Other Name: see arm/group descriptions
Active Comparator: morphine; Morphine (1 mg/mL) administered orally every 4 hours. The following is a dosing guide: NAS Score Morphine 8-12 0.05 mg/kg/dose >=13 0.1 mg/kg/dose; Maximum dose of morphine will be 0.2 mg/kg/dose. (NeoFax); Additional doses, 0.05 mg/kg, may be given every 4 hours as needed and added to the next 24 hour's doses divided every 6 hours, until NAS scores are consistently <8 for 48 hours.; If the maximum dose of morphine is reached and if withdrawal is not controlled, the infant will be started on clonazepam (0.005 mg/kg/dose q 12h) per current treatment.	Drug: Morphine; To compare the duration of opiate medication treatment for babies on methadone versus those on morphine.; Other Name: see arm/group descriptions

Outcome Measures

Primary Outcome Measures :

1. Days of Treatment With Opioid Medication [ Time Frame: From date of randomization until the date of last opioid dose or date of death from any cause, whichever came first, assessed up to 12 months ]
   The length of time in days that the treatment opioid was used on a measured taper to ameliorate withdrawal signs

Secondary Outcome Measures :

1. Second Drug for Withdrawal [ Time Frame: From date of randomization until the date of last opioid dose or date of death from any cause or date of discharge, whichever came first, assessed up to 12 months ]
   Number of infants treated with a second drug to treat their withdrawal

Eligibility Criteria

• Ages Eligible for Study: up to 28 Days (Child)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Criteria

Inclusion Criteria:

i. Evidence of opioid withdrawal clinically defined by at least 2 NAS scores > 8 in an 8 hour time period, AND

ii. Gestation => 35 weeks at entry defined by best obstetrical and physical exam criteria, AND

iii. Medically stable condition in the opinion of the attending neonatologist, other than opiate withdrawal, AND

iv. Mother on opiate replacement treatment therapy - methadone or buprenorphine.

Exclusion Criteria:

i. Gestation < 35 weeks at entry defined by best obstetrical and physical exam criteria.

ii. Hypoglycemia, hypomagnesaemia, or hypocalcemia until corrected,

iii. Serious medical illness such as sepsis, pneumonia, thyroid dysfunction, meningitis, intracranial hemorrhage, perinatal depression, or respiratory failure requiring admission to the NICU.

iv. Evidence of major congenital anomalies or genetic syndromes that impact the neonatal course

v. Mother consistently taking prescribed benzodiazepine at the time of delivery

Contacts and Locations

Sponsors and Collaborators

Eastern Maine Medical Center

Investigators

• Principal Investigator: Mark Brown, MD; Eastern Maine Medical Center

More Information

• Responsible Party: Mark S Brown, MD, Chief of Pediatric Service, Neonatalogy, Eastern Maine Medical Center
• ClinicalTrials.gov Identifier: NCT01804075
• Other Study ID Numbers: 10-1-M-185
• First Posted: March 5, 2013
• Results First Posted: August 30, 2017
• Last Update Posted: September 28, 2017
• Last Verified: August 2017

Keywords provided by Mark S Brown, MD, Eastern Maine Medical Center:

NAS; NICU; EMMC

Additional relevant MeSH terms:

Neonatal Abstinence Syndrome; Syndrome; Disease; Pathologic Processes; Infant, Newborn, Diseases; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders; Morphine; Methadone; Analgesics, Opioid; Narcotics; Central Nervous System Depressants; Physiological Effects of Drugs; Analgesics; Sensory System Agents; Peripheral Nervous System Agents; Antitussive Agents; Respiratory System Agents