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Armodafinil in Reducing Cancer-Related Fatigue in Patients With High Grade Glioma

This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2016 by Alliance for Clinical Trials in Oncology
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier:
NCT01781468
First received: January 29, 2013
Last updated: November 16, 2016
Last verified: November 2016
  Purpose
This randomized phase III trial studies armodafinil to see how well it works in reducing cancer-related fatigue in patients with high grade glioma. Armodafinil may help relieve fatigue in patients with high grade glioma.

Condition Intervention Phase
Fatigue
Drug: armodafinil 150 mg
Other: Placebo
Drug: armodafinil 250 mg
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Supportive Care
Official Title: A Phase III Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil®) To Reduce Cancer-Related Fatigue in Patients With High Grade Glioma

Resource links provided by NLM:


Further study details as provided by Alliance for Clinical Trials in Oncology:

Primary Outcome Measures:
  • Response rate in terms of a clinically meaningful improvement in patient-reported fatigue at 8 weeks. A response is defined as an improvement of 2 points on the 0-10 scale of the usual fatigue on the Brief Fatigue Inventory (BFI). [ Time Frame: Up to 8 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Fatigue: Brief Fatigue Inventory (BFI), Patient Reported Outcomes - Common Terminology Criteria for Adverse Events (PRO-CTCAE) and the summated score from the Patient Reported Outcomes Measurement Information System (PROMIS) [ Time Frame: Up to 8 weeks ] [ Designated as safety issue: Yes ]
  • Cognitive function: As Assessed by Symbol Digit Modalities Test (SDMT), Controlled Oral Word Association, Trail Making Test, and the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) [ Time Frame: Up to 8 weeks ] [ Designated as safety issue: No ]
  • Quality of Life as measured by Linear Analogue Self Assessment (LASA) [ Time Frame: Up to 8 weeks ] [ Designated as safety issue: No ]
  • Proportion of patients reporting adverse events via the CTCAE version 4.0 items [ Time Frame: Up to 8 weeks ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 330
Study Start Date: June 2013
Estimated Primary Completion Date: May 2020 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I
Patients receive 150 mg armodafinil orally every day in the morning for 8 weeks.
Drug: armodafinil 150 mg
given orally
Placebo Comparator: Arm II
Patients receive placebo orally every day in the morning for 8 weeks.
Other: Placebo
given orally
Experimental: Arm III
Patients receive 250 mg armodafinil orally every day in the morning for 8 weeks.
Drug: armodafinil 250 mg
given orally

Detailed Description:

Patients experiencing fatigue related to cancer will be asked to take part in this study. Cancer-related fatigue is a very common symptom in patients with cancer. Patients will receive armodafinil or placebo. Please see the "Arms" section for more details regarding the treatment assignments. The primary objective of this study is to determine preliminary efficacy measured by patient reported fatigue Brief Fatigue Inventory (BFI) at 8 weeks of two doses (150 mg and 250 mg) of armodafinil in treating moderate fatigue compared to placebo in patients with high grade glioma.

The secondary objectives of the study are listed below.

  1. To evaluate the tolerability at 8 weeks of 150 mg and 250 mg armodafinil in this patient population.
  2. To assess the effect of armodafinil at 8 weeks on cognitive function in patients with high grade glioma.
  3. To assess the impact of armodafinil on global quality of life and other fatigue endpoints in this patient population with high grade glioma.
  4. Explore the correlation between the BFI, Patient-Reported Outcomes Measurement Information System (PROMIS), and Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) measures, as well as, the relationship of fatigue and cognitive difficulties.

Patients will receive armodafinil or placebo for a total of 8 weeks.

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age ≥ 18 years
  • Diagnosed with glioblastoma, gliosarcoma, small cell or large cell glioblastoma, glioblastoma with oligo features, glioblastoma with primitive neuroectodermal tumor-like components (GBM-PNET) features, anaplastic astrocytoma, anaplastic oligodendroglioma, or anaplastic oligoastrocytoma who are clinically stable and have completed radiation therapy > 21 days and ≤ 24 months prior to enrollment. NOTE: Clinical stability will be defined as a stable or improved Karnofsky Performance Status (KPS) compared to the prior month.
  • ≥ 6 score on the worst fatigue question of the BFI (Brief Fatigue Inventory). It is not required for the patient to complete the entire BFI to meet this criterion.
  • Undergone surgery (gross total or subtotal resection) or biopsy and will have been treated with concurrent radiation therapy and chemotherapy as standard of care for glioblastoma, gliosarcoma, small cell or large cell glioblastoma, glioblastoma with oligo features, glioblastoma with primitive neuroectodermal tumor-like components (GBM-PNET) features,anaplastic astrocytoma, anaplastic oligodendroglioma or anaplastic oligoastrocytoma patients. NOTE: Radiation must be completed per the second eligibility criteria, but chemotherapy is allowed.
  • Negative serum pregnancy test done ≤ 7 days prior to registration only for women determined to be of childbearing potential by the treating physician.
  • Ability to complete questionnaire(s) by themselves or with assistance
  • Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0, 1, 2 or 3
  • Provide informed written consent
  • Willing to return to enrolling institution for follow-up (during the Active Monitoring Phase of the study)
  • Stable dose of corticosteroid ≥ 14 days prior to registration

Exclusion Criteria:

  • Pregnant women, nursing women, men or women of childbearing potential who are unwilling to employ adequate contraception since this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown.
  • History of hypersensitivity to other psychostimulants
  • History of steroid psychosis
  • History of or currently taking medications for attention deficit hyperactivity disorder, severe anxiety disorder, schizophrenia, or substance abuse by patient record and/or self report
  • Currently using any other pharmacologic agents or nonpharmacologic interventions to specifically treat fatigue including psychostimulants, antidepressants, acupuncture, etc. will be excluded. Note: antidepressants used to treat items other than fatigue (such as hot flashes or depression) are allowed if the patient has been on a stable dose for ≥ 30 days prior to registration and plans to continue for the duration of the trial. Erythropoietin agents to treat anemia are allowed. Exercise is allowed.
  • Anticipating surgery, laboratory evidence of hypothyroidism with an elevated thyroid stimulating hormone (TSH) concentration in the blood > 5.0 mlU/L, profound anemia (hemoglobin level of < 10 g/dL ≤ 28 days prior to registration), or clinical depression per physician discretion.
  • Active or a history of Tourrette's syndrome or tic disorder
  • History of or active glaucoma
  • History of intractable epilepsy, or uncontrolled seizure disorder
  • Any of the following co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens:

    1. History of myocardial infarction
    2. Unstable angina
    3. Left ventricular hypertrophy
    4. Mitral valve prolapse syndrome
  • Receiving any medications or substances that are strong or moderate inhibitors of cytochrome P450 3A4 (CYP3A4). Use of strong or moderate inhibitors specified in the protocol are prohibited ≤ 7 days prior to registration. See the protocol for more information.
  • Receiving any medications or substances that are inducers of CYP3A4. Use of inducers specified in the protocol are prohibited ≤ 7 days prior to registration. See the protocol for more information.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01781468

Contacts
Contact: Alyx B. Porter Umphrey, MD (507) 266-5230

  Hide Study Locations
Locations
United States, Alaska
Alaska Breast Care and Surgery LLC Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Alaska Women's Cancer Care Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Anchorage Oncology Centre Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Katmai Oncology Group Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Providence Alaska Medical Center Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
United States, Arizona
Saint Joseph's Hospital and Medical Center Recruiting
Phoenix, Arizona, United States, 85013
Contact: David G. Brachman    800-360-6371      
Principal Investigator: David G. Brachman         
Arizona Oncology-Deer Valley Center Suspended
Phoenix, Arizona, United States, 85027
Mayo Clinic in Arizona Recruiting
Scottsdale, Arizona, United States, 85259
Contact: Alyx B. Umphrey    855-776-0015      
Principal Investigator: Alyx B. Umphrey         
Arizona Oncology Services Foundation Recruiting
Scottsdale, Arizona, United States, 85260
Contact: David G. Brachman    800-360-6371      
Principal Investigator: David G. Brachman         
United States, California
Alta Bates Summit Medical Center-Herrick Campus Recruiting
Berkeley, California, United States, 94704
Contact: Milana V. Dolezal    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Milana V. Dolezal         
Mills - Peninsula Hospitals Recruiting
Burlingame, California, United States, 94010
Contact: Milana V. Dolezal    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Milana V. Dolezal         
John Muir Medical Center-Concord Campus Withdrawn
Concord, California, United States, 94520
University Oncology Associates Recruiting
Fresno, California, United States, 93701
Contact: Uzair B. Chaudhary    559-256-9680      
Principal Investigator: Uzair B. Chaudhary         
California Cancer Center - North Fresno Recruiting
Fresno, California, United States, 93720
Contact: Uzair B. Chaudhary    559-256-9680      
Principal Investigator: Uzair B. Chaudhary         
UC San Diego Moores Cancer Center Active, not recruiting
La Jolla, California, United States, 92093
Memorial Medical Center Recruiting
Modesto, California, United States, 95355
Contact: Milana V. Dolezal    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Milana V. Dolezal         
Saint Joseph Hospital - Orange Recruiting
Orange, California, United States, 92868
Contact: Hector W. Ho    714-734-6220      
Principal Investigator: Hector W. Ho         
UC Irvine Health/Chao Family Comprehensive Cancer Center Recruiting
Orange, California, United States, 92868
Contact: Jose A. Carrillo    877-827-8839    ucstudy@uci.edu   
Principal Investigator: Jose A. Carrillo         
Kaiser Permanente Medical Center - Santa Clara Suspended
Santa Clara, California, United States, 95051
Kaiser Permanente-Vallejo Suspended
Vallejo, California, United States, 94589
United States, Colorado
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
Rocky Mountain Cancer Centers-Penrose Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
SCL Health Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
United States, Delaware
Helen F Graham Cancer Center Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Medical Oncology Hematology Consultants PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Regional Hematology and Oncology PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
United States, Florida
Florida Hospital Memorial Medical Center Suspended
Daytona Beach, Florida, United States, 32117
Lakeland Regional Cancer Center Recruiting
Lakeland, Florida, United States, 33805
Contact: Madhavi L. Venigalla    863-904-1900      
Principal Investigator: Madhavi L. Venigalla         
University of Miami Miller School of Medicine-Sylvester Cancer Center Suspended
Miami, Florida, United States, 33136
Florida Hospital Orlando Active, not recruiting
Orlando, Florida, United States, 32803
Sacred Heart Hospital Recruiting
Pensacola, Florida, United States, 32504
Contact: Thomas D. Sunnenberg    850-416-4611      
Principal Investigator: Thomas D. Sunnenberg         
Sacred Heart Medical Oncology Group - Davis Highway Recruiting
Pensacola, Florida, United States, 32514
Contact: Thomas D. Sunnenberg    850-416-4611      
Principal Investigator: Thomas D. Sunnenberg         
United States, Georgia
Piedmont Hospital Recruiting
Atlanta, Georgia, United States, 30309
Contact: Erin M. Dunbar    404-425-7943    ORS@piedmont.org   
Principal Investigator: Erin M. Dunbar         
Augusta University Medical Center Suspended
Augusta, Georgia, United States, 30912
Northeast Georgia Medical Center Recruiting
Gainesville, Georgia, United States, 30501
Contact: Kendal P. Dixon    770-219-8800    cancerpatient.navigator@nghs.com   
Principal Investigator: Kendal P. Dixon         
United States, Hawaii
Hawaii Oncology Inc-Pali Momi Suspended
Aiea, Hawaii, United States, 96701
Pali Momi Medical Center Suspended
Aiea, Hawaii, United States, 96701
The Cancer Center of Hawaii-Leeward Suspended
Ewa Beach, Hawaii, United States, 96706
Hawaii Cancer Care Inc-POB II Suspended
Honolulu, Hawaii, United States, 96813
Queen's Medical Center Suspended
Honolulu, Hawaii, United States, 96813
Straub Clinic and Hospital Suspended
Honolulu, Hawaii, United States, 96813
University of Hawaii Cancer Center Suspended
Honolulu, Hawaii, United States, 96813
Hawaii Cancer Care Inc-Liliha Suspended
Honolulu, Hawaii, United States, 96817
Hawaii Oncology Inc-Kuakini Suspended
Honolulu, Hawaii, United States, 96817
The Cancer Center of Hawaii-Liliha Suspended
Honolulu, Hawaii, United States, 96817
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Samir Narayan    734-712-4673      
Principal Investigator: Samir Narayan         
Kootenai Medical Center Recruiting
Coeur D'Alene, Idaho, United States, 83814
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Illinois
Illinois CancerCare-Bloomington Recruiting
Bloomington, Illinois, United States, 61704
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Canton Recruiting
Canton, Illinois, United States, 61520
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Carthage Recruiting
Carthage, Illinois, United States, 62321
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Centralia Oncology Clinic Recruiting
Centralia, Illinois, United States, 62801
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Cancer Care Center of Decatur Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Crossroads Cancer Center Recruiting
Effingham, Illinois, United States, 62401
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
NorthShore University HealthSystem-Evanston Hospital Recruiting
Evanston, Illinois, United States, 60201
Contact: Ryan T. Merrell    847-570-2109      
Principal Investigator: Ryan T. Merrell         
Illinois CancerCare-Galesburg Recruiting
Galesburg, Illinois, United States, 61401
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
NorthShore University HealthSystem-Glenbrook Hospital Recruiting
Glenview, Illinois, United States, 60026
Contact: Ryan T. Merrell    847-570-2109      
Principal Investigator: Ryan T. Merrell         
NorthShore University HealthSystem-Highland Park Hospital Recruiting
Highland Park, Illinois, United States, 60035
Contact: Ryan T. Merrell    847-570-2109      
Principal Investigator: Ryan T. Merrell         
Illinois CancerCare-Kewanee Clinic Recruiting
Kewanee, Illinois, United States, 61443
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Trinity Medical Center Recruiting
Moline, Illinois, United States, 61265
Contact: David M. Spector    309-779-4200      
Principal Investigator: David M. Spector         
Illinois CancerCare-Ottawa Clinic Recruiting
Ottawa, Illinois, United States, 61350
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Pekin Recruiting
Pekin, Illinois, United States, 61554
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Methodist Medical Center of Illinois Recruiting
Peoria, Illinois, United States, 61603
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Peru Recruiting
Peru, Illinois, United States, 61354
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Princeton Recruiting
Princeton, Illinois, United States, 61356
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Southern Illinois University School of Medicine Recruiting
Springfield, Illinois, United States, 62702
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Springfield Clinic Recruiting
Springfield, Illinois, United States, 62703
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Maria T. Grosse-Perdekamp    800-446-5532      
Principal Investigator: Maria T. Grosse-Perdekamp         
Northwestern Medicine Cancer Center Warrenville Recruiting
Warrenville, Illinois, United States, 60555
Contact: Sean A. Grimm    630-315-1918    Claudine.Gamster@CadenceHealth.org   
Principal Investigator: Sean A. Grimm         
United States, Indiana
Michiana Hematology Oncology PC-Crown Point Suspended
Crown Point, Indiana, United States, 46307
Elkhart Clinic Suspended
Elkhart, Indiana, United States, 46514-2098
Michiana Hematology Oncology PC-Elkhart Suspended
Elkhart, Indiana, United States, 46514
Elkhart General Hospital Suspended
Elkhart, Indiana, United States, 46515
Community Howard Regional Health Suspended
Kokomo, Indiana, United States, 46904
IU Health La Porte Hospital Suspended
La Porte, Indiana, United States, 46350
Memorial Regional Cancer Center Day Road Recruiting
Mishawaka, Indiana, United States, 46544
Contact: Thomas J. Reid    800-284-7370      
Principal Investigator: Thomas J. Reid         
Michiana Hematology Oncology PC-Mishawaka Suspended
Mishawaka, Indiana, United States, 46545
Saint Joseph Regional Medical Center-Mishawaka Suspended
Mishawaka, Indiana, United States, 46545
Michiana Hematology Oncology PC-Plymouth Suspended
Plymouth, Indiana, United States, 46563
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Thomas J. Reid    800-284-7370      
Principal Investigator: Thomas J. Reid         
Michiana Hematology Oncology PC-South Bend Suspended
South Bend, Indiana, United States, 46601
Northern Indiana Cancer Research Consortium Recruiting
South Bend, Indiana, United States, 46628
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Michiana Hematology Oncology PC-Westville Suspended
Westville, Indiana, United States, 46391
United States, Iowa
Mary Greeley Medical Center Suspended
Ames, Iowa, United States, 50010
McFarland Clinic PC-William R Bliss Cancer Center Suspended
Ames, Iowa, United States, 50010
Mercy Hospital Recruiting
Cedar Rapids, Iowa, United States, 52403
Contact: Deborah W. Wilbur    515-241-3305      
Principal Investigator: Deborah W. Wilbur         
Oncology Associates at Mercy Medical Center Recruiting
Cedar Rapids, Iowa, United States, 52403
Contact: Deborah W. Wilbur    515-241-3305      
Principal Investigator: Deborah W. Wilbur         
Medical Oncology and Hematology Associates-West Des Moines Recruiting
Clive, Iowa, United States, 50325
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
Mercy Cancer Center-West Lakes Recruiting
Clive, Iowa, United States, 50325
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
Greater Regional Medical Center Recruiting
Creston, Iowa, United States, 50801
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
Iowa-Wide Oncology Research Coalition NCORP Terminated
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates-Laurel Recruiting
Des Moines, Iowa, United States, 50314
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
Mercy Medical Center - Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
Mercy Medical Center - North Iowa Recruiting
Mason City, Iowa, United States, 50401
Contact: Joginder (Joe) Singh    800-433-3883      
Principal Investigator: Joginder (Joe) Singh         
Siouxland Regional Cancer Center Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
Mercy Medical Center-West Lakes Recruiting
West Des Moines, Iowa, United States, 50266
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
United States, Kansas
Cancer Center of Kansas - Chanute Recruiting
Chanute, Kansas, United States, 66720
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Dodge City Recruiting
Dodge City, Kansas, United States, 67801
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - El Dorado Recruiting
El Dorado, Kansas, United States, 67042
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Fort Scott Recruiting
Fort Scott, Kansas, United States, 66701
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Independence Recruiting
Independence, Kansas, United States, 67301
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Kingman Recruiting
Kingman, Kansas, United States, 67068
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Lawrence Memorial Hospital Recruiting
Lawrence, Kansas, United States, 66044
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Liberal Recruiting
Liberal, Kansas, United States, 67905
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Newton Recruiting
Newton, Kansas, United States, 67114
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Parsons Recruiting
Parsons, Kansas, United States, 67357
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Pratt Recruiting
Pratt, Kansas, United States, 67124
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Salina Recruiting
Salina, Kansas, United States, 67401
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Wellington Recruiting
Wellington, Kansas, United States, 67152
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Associates In Womens Health Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Wichita Medical Arts Tower Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Wichita Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Via Christi Regional Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Winfield Recruiting
Winfield, Kansas, United States, 67156
Contact: Shaker R. Dakhil    316-268-5374      
Principal Investigator: Shaker R. Dakhil         
United States, Kentucky
Baptist Health Corbin Recruiting
Corbin, Kentucky, United States, 40701
Contact: Firas B. Badin    859-260-6425      
Principal Investigator: Firas B. Badin         
Baptist Health Lexington Recruiting
Lexington, Kentucky, United States, 40503
Contact: Firas B. Badin    859-260-6425      
Principal Investigator: Firas B. Badin         
University of Kentucky/Markey Cancer Center Recruiting
Lexington, Kentucky, United States, 40536
Contact: John L. Villano    859-257-3379      
Principal Investigator: John L. Villano         
Baptist Health Paducah Recruiting
Paducah, Kentucky, United States, 42003
Contact: Firas B. Badin    859-260-6425      
Principal Investigator: Firas B. Badin         
United States, Louisiana
The NeuroMedical Center-Clinic Recruiting
Baton Rouge, Louisiana, United States, 70810
Contact: Augusto C. Ochoa    504-568-2428    emede1@lsuhsc.edu   
Principal Investigator: Augusto C. Ochoa         
United States, Maine
Central Maine Medical Center Recruiting
Lewiston, Maine, United States, 04240
Contact: Daniel C. Rausch    207-795-8250    benderli@cmhc.org   
Principal Investigator: Daniel C. Rausch         
United States, Maryland
Unspecified Site Recruiting
Rockville, Maryland, United States, 20852
Contact: Alyx B. Umphrey    507-266-5230    porter.alyx@mayo.edu   
Principal Investigator: Alyx B. Umphrey         
United States, Massachusetts
Tufts Medical Center Recruiting
Boston, Massachusetts, United States, 02111
Contact: Suriya Jeyapalan    617-636-5000    ContactUsCancerCenter@TuftsMedicalCenter.org   
Principal Investigator: Suriya Jeyapalan         
Boston Medical Center Suspended
Boston, Massachusetts, United States, 02118
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Samir Narayan    734-712-4673      
Principal Investigator: Samir Narayan         
Bronson Battle Creek Recruiting
Battle Creek, Michigan, United States, 49017
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Samir Narayan    734-712-4673      
Principal Investigator: Samir Narayan         
Cancer Research Consortium of West Michigan NCORP Terminated
Grand Rapids, Michigan, United States, 49503
Mercy Health Saint Mary's Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Marquette General Hospital Recruiting
Marquette, Michigan, United States, 49855
Contact: Philip A. Lowry    508-856-3216    cancer.research@umassmed.edu   
Principal Investigator: Philip A. Lowry         
William Beaumont Hospital-Royal Oak Recruiting
Royal Oak, Michigan, United States, 48073
Contact: John M. Robertson    248-551-7695      
Principal Investigator: John M. Robertson         
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Samir Narayan    734-712-4673      
Principal Investigator: Samir Narayan         
Marie Yeager Cancer Center Suspended
Saint Joseph, Michigan, United States, 49085
Providence Hospital-Southfield Cancer Center Recruiting
Southfield, Michigan, United States, 48075
Contact: Susan E. Lyons    248-849-5337    jaswinder.grewal@stjohn.org   
Principal Investigator: Susan E. Lyons         
Lakeland Hospital Suspended
St. Joseph, Michigan, United States, 49085
William Beaumont Hospital - Troy Recruiting
Troy, Michigan, United States, 48098
Contact: John M. Robertson    248-551-7695      
Principal Investigator: John M. Robertson         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Samir Narayan    734-712-4673      
Principal Investigator: Samir Narayan         
United States, Minnesota
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Essentia Health Cancer Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Health Partners Inc Recruiting
Minneapolis, Minnesota, United States, 55454
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Alyx B. Umphrey    855-776-0015      
Principal Investigator: Alyx B. Umphrey         
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Minnesota Oncology and Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Joseph W. Leach    952-993-1517    mmcorc@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United States, Missouri
Central Care Cancer Center-Carrie J Babb Cancer Center Recruiting
Bolivar, Missouri, United States, 65613
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
Saint Luke's Hospital Recruiting
Chesterfield, Missouri, United States, 63017
Contact: Donald F. Busiek    314-205-6936      
Principal Investigator: Donald F. Busiek         
Freeman Health System Recruiting
Joplin, Missouri, United States, 64804
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
Saint Luke's Hospital of Kansas City Recruiting
Kansas City, Missouri, United States, 64111
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Jian L. Campian    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Jian L. Campian         
Mercy Hospital Saint Louis Active, not recruiting
Saint Louis, Missouri, United States, 63141
Mercy Hospital Springfield Recruiting
Springfield, Missouri, United States, 65804
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
United States, Montana
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Montana Cancer Consortium NCORP Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Nebraska
CHI Health Good Samaritan Recruiting
Kearney, Nebraska, United States, 68847
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
Nebraska Cancer Research Center Recruiting
Lincoln, Nebraska, United States, 68510
Contact: Gamini S. Soori    402-393-3110      
Principal Investigator: Gamini S. Soori         
Alegent Health Lakeside Hospital Recruiting
Omaha, Nebraska, United States, 68130
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
Creighton University Medical Center Recruiting
Omaha, Nebraska, United States, 68131
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
United States, Nevada
Nevada Cancer Research Foundation CCOP Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton    702-384-0013      
Principal Investigator: John A. Ellerton         
United States, New Hampshire
New Hampshire Oncology Hematology PA-Concord Recruiting
Concord, New Hampshire, United States, 03301
Contact: Douglas J. Weckstein    603-224-2556      
Principal Investigator: Douglas J. Weckstein         
New Hampshire Oncology Hematology PA-Hooksett Recruiting
Hooksett, New Hampshire, United States, 03106
Contact: Douglas J. Weckstein    603-224-2556      
Principal Investigator: Douglas J. Weckstein         
LRGHealthcare-Lakes Region General Hospital Suspended
Laconia, New Hampshire, United States, 03246
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Paula K. Rauschkolb    217-545-7929      
Principal Investigator: Paula K. Rauschkolb         
United States, New Jersey
Robert Wood Johnson University Hospital Somerset Suspended
Somerville, New Jersey, United States, 08876
United States, New York
Hematology Oncology Associates of Central New York-East Syracuse Recruiting
East Syracuse, New York, United States, 13057
Contact: Jeffrey J. Kirshner    315-472-7504      
Principal Investigator: Jeffrey J. Kirshner         
Memorial Sloan-Kettering Cancer Center Suspended
New York, New York, United States, 10065
Highland Hospital Recruiting
Rochester, New York, United States, 14620
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
University Radiation Oncology Recruiting
Rochester, New York, United States, 14626
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
United States, North Carolina
Southeastern Medical Oncology Center-Clinton Recruiting
Clinton, North Carolina, United States, 28328
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Southeastern Medical Oncology Center-Goldsboro Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Wayne Memorial Hospital Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Park Ridge Hospital Breast Health Center Active, not recruiting
Hendersonville, North Carolina, United States, 28792
Southeastern Medical Oncology Center-Jacksonville Recruiting
Jacksonville, North Carolina, United States, 28546
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Kinston Medical Specialists PA Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson    252-559-2200      
Principal Investigator: Peter R. Watson         
Southeastern Medical Oncology Center-Wilson Recruiting
Wilson, North Carolina, United States, 27893
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
United States, North Dakota
Altru Cancer Center Recruiting
Grand Forks, North Dakota, United States, 58201
Contact: Grant R. Seeger    701-780-6520      
Principal Investigator: Grant R. Seeger         
United States, Ohio
Akron General Medical Center Recruiting
Akron, Ohio, United States, 44307
Contact: Esther H. Rehmus    330-344-6348      
Principal Investigator: Esther H. Rehmus         
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Mercy Cancer Center-Elyria Active, not recruiting
Elyria, Ohio, United States, 44035
Toledo Clinic Cancer Centers-Maumee Recruiting
Maumee, Ohio, United States, 43537
Contact: Rex B. Mowat    800-444-3561      
Principal Investigator: Rex B. Mowat         
Saint Charles Hospital Recruiting
Oregon, Ohio, United States, 43616
Contact: Rex B. Mowat    800-444-3561      
Principal Investigator: Rex B. Mowat         
University of Toledo Recruiting
Toledo, Ohio, United States, 43614
Contact: Krishna Reddy    419-383-6583      
Principal Investigator: Krishna Reddy         
Mercy Saint Anne Hospital Recruiting
Toledo, Ohio, United States, 43623
Contact: Rex B. Mowat    800-444-3561      
Principal Investigator: Rex B. Mowat         
Toledo Clinic Cancer Centers-Toledo Recruiting
Toledo, Ohio, United States, 43623
Contact: Rex B. Mowat    800-444-3561      
Principal Investigator: Rex B. Mowat         
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: James D. Battiste    405-271-8777    ou-clinical-trials@ouhsc.edu   
Principal Investigator: James D. Battiste         
Saint John Medical Center Suspended
Tulsa, Oklahoma, United States, 74104
United States, Oregon
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Legacy Mount Hood Medical Center Recruiting
Gresham, Oregon, United States, 97030
Contact: Regan M. Look    503-280-1223      
Principal Investigator: Regan M. Look         
Providence Newberg Medical Center Recruiting
Newberg, Oregon, United States, 97132
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Providence Willamette Falls Medical Center Recruiting
Oregon City, Oregon, United States, 97045
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Legacy Good Samaritan Hospital and Medical Center Recruiting
Portland, Oregon, United States, 97210
Contact: Regan M. Look    503-280-1223      
Principal Investigator: Regan M. Look         
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Kaiser Permanente Northwest Recruiting
Portland, Oregon, United States, 97227
Contact: Sandeep H. Mashru    503-335-2400      
Principal Investigator: Sandeep H. Mashru         
Legacy Meridian Park Hospital Recruiting
Tualatin, Oregon, United States, 97062
Contact: Regan M. Look    503-280-1223      
Principal Investigator: Regan M. Look         
United States, Pennsylvania
Lehigh Valley Hospital-Cedar Crest Recruiting
Allentown, Pennsylvania, United States, 18103
Contact: Suresh G. Nair    610-402-2273      
Principal Investigator: Suresh G. Nair         
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822
Contact: Scott G. Turner    570-271-5251      
Principal Investigator: Scott G. Turner         
Adams Cancer Center Suspended
Gettysburg, Pennsylvania, United States, 17325
Cherry Tree Cancer Center Suspended
Hanover, Pennsylvania, United States, 17331
Geisinger Wyoming Valley/Henry Cancer Center Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Scott G. Turner    570-271-5251      
Principal Investigator: Scott G. Turner         
WellSpan Health-York Hospital Suspended
York, Pennsylvania, United States, 17403
United States, South Carolina
AnMed Health Cancer Center Active, not recruiting
Anderson, South Carolina, United States, 29621
Greenville Health System Cancer Institute-Easley Recruiting
Easley, South Carolina, United States, 29640
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Gibbs Cancer Center-Gaffney Recruiting
Gaffney, South Carolina, United States, 29341
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Greenville Health System Cancer Institute-Andrews Suspended
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Butternut Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Eastside Recruiting
Greenville, South Carolina, United States, 29615
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute-Greer Recruiting
Greer, South Carolina, United States, 29650
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Gibbs Cancer Center-Pelham Recruiting
Greer, South Carolina, United States, 29651
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Spartanburg Medical Center Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
United States, South Dakota
Avera Cancer Institute-Aberdeen Recruiting
Aberdeen, South Dakota, United States, 57401
Contact: Amy K. Krie    888-634-7268    oncregulatory@avera.org   
Principal Investigator: Amy K. Krie         
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Joshua C. Lukenbill    605-716-3982    research@rcrh.org   
Principal Investigator: Joshua C. Lukenbill         
Avera Cancer Institute Recruiting
Sioux Falls, South Dakota, United States, 57105
Contact: Amy K. Krie    888-634-7268    oncregulatory@avera.org   
Principal Investigator: Amy K. Krie         
United States, Texas
University of Texas Health Science Center at San Antonio Recruiting
San Antonio, Texas, United States, 78229
Contact: Andrew J. Brenner    210-450-3800      
Principal Investigator: Andrew J. Brenner         
United States, Utah
Huntsman Cancer Institute/University of Utah Active, not recruiting
Salt Lake City, Utah, United States, 84112
United States, Washington
Providence Regional Cancer System-Aberdeen Recruiting
Aberdeen, Washington, United States, 98520
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
MultiCare Auburn Medical Center Recruiting
Auburn, Washington, United States, 98001
Contact: John A. Keech    253-403-2394      
Principal Investigator: John A. Keech         
PeaceHealth Saint Joseph Medical Center Recruiting
Bellingham, Washington, United States, 98225
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Highline Medical Center-Main Campus Recruiting
Burien, Washington, United States, 98166
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
Providence Regional Cancer System-Centralia Recruiting
Centralia, Washington, United States, 98531
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
MultiCare Gig Harbor Medical Park Recruiting
Gig Harbor, Washington, United States, 98335
Contact: John A. Keech    253-403-2394      
Principal Investigator: John A. Keech         
Providence Regional Cancer System-Lacey Recruiting
Lacey, Washington, United States, 98503
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
PeaceHealth Saint John Medical Center Recruiting
Longview, Washington, United States, 98632
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
MultiCare Good Samaritan Hospital Recruiting
Puyallup, Washington, United States, 98372
Contact: John A. Keech    253-403-2394      
Principal Investigator: John A. Keech         
Providence Regional Cancer System-Shelton Recruiting
Shelton, Washington, United States, 98584
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
MultiCare Tacoma General Hospital Recruiting
Tacoma, Washington, United States, 98405
Contact: John A. Keech    253-403-2394      
Principal Investigator: John A. Keech         
Northwest NCI Community Oncology Research Program Terminated
Tacoma, Washington, United States, 98405
Multicare Health System Suspended
Tacoma, Washington, United States, 98415
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
Legacy Salmon Creek Hospital Recruiting
Vancouver, Washington, United States, 98686
Contact: Regan M. Look    503-280-1223      
Principal Investigator: Regan M. Look         
Providence Regional Cancer System-Yelm Recruiting
Yelm, Washington, United States, 98597
Contact: Keith S. Lanier    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Keith S. Lanier         
United States, West Virginia
West Virginia University Healthcare Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Javier Gonzalez    304-293-2745    sfilburn@hsc.wvu.edu   
Principal Investigator: Javier Gonzalez         
United States, Wisconsin
Green Bay Oncology at Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301-3526
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Green Bay Oncology Limited at Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311
Contact: George C. Bobustuc    414-649-5717      
Principal Investigator: George C. Bobustuc         
Gundersen Lutheran Medical Center Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Michael O. Ojelabi    608-775-2385    cancerctr@gundersenhealth.org   
Principal Investigator: Michael O. Ojelabi         
University of Wisconsin Hospital and Clinics Suspended
Madison, Wisconsin, United States, 53792
Holy Family Memorial Hospital Recruiting
Manitowoc, Wisconsin, United States, 54221
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Marshfield Clinic Suspended
Marshfield, Wisconsin, United States, 54449
Aurora Saint Luke's Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: George C. Bobustuc    414-649-5717      
Principal Investigator: George C. Bobustuc         
Froedtert and the Medical College of Wisconsin Suspended
Milwaukee, Wisconsin, United States, 53226
D N Greenwald Center Recruiting
Mukwonago, Wisconsin, United States, 53149
Contact: Timothy R. Wassenaar    262-928-5539    Chanda.miller@phci.org   
Principal Investigator: Timothy R. Wassenaar         
Oconomowoc Memorial Hospital-ProHealth Care Inc Recruiting
Oconomowoc, Wisconsin, United States, 53066
Contact: Timothy R. Wassenaar    262-928-5539    Chanda.miller@phci.org   
Principal Investigator: Timothy R. Wassenaar         
UW Cancer Center at ProHealth Care Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Timothy R. Wassenaar    262-928-5539    Chanda.miller@phci.org   
Principal Investigator: Timothy R. Wassenaar         
Waukesha Memorial Hospital Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Timothy R. Wassenaar    262-928-5539    Chanda.miller@phci.org   
Principal Investigator: Timothy R. Wassenaar         
Sponsors and Collaborators
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)
Investigators
Study Chair: Alyx B. Porter Umphrey, MD Mayo Clinic
  More Information

Responsible Party: Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier: NCT01781468     History of Changes
Other Study ID Numbers: A221101  N10C3  NCI-2012-02020  U10CA037404  U10CA037447  UG1CA189823 
Study First Received: January 29, 2013
Last Updated: November 16, 2016
Health Authority: United States: Food and Drug Administration
United States: Institutional Review Board

Additional relevant MeSH terms:
Fatigue
Signs and Symptoms
Armodafinil
Modafinil
Wakefulness-Promoting Agents
Central Nervous System Stimulants
Physiological Effects of Drugs
Cytochrome P-450 CYP3A Inducers
Cytochrome P-450 Enzyme Inducers
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on December 05, 2016