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Effect of Acupuncture on Anti Mullerian Hormone and Assisted Reproduction Outcome in PCOS Patients Undergoing IVF

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01778621
Recruitment Status : Completed
First Posted : January 29, 2013
Last Update Posted : July 23, 2019
Huazhong University of Science and Technology
Information provided by (Responsible Party):
Amina Altutunji, Huazhong University of Science and Technology

Brief Summary:
Acupuncture at follicular phase of the cycle may improve the pregnancy rate. This study aims to compare assisted reproduction outcome between two groups of PCOS patients underwent IVF, one group received acupuncture and other group without acupuncture.

Condition or disease Intervention/treatment Phase
PCOS Device: Acupuncture(Hwato®) Not Applicable

Detailed Description:
Follicular phase acupuncture applied for PCOS patients underwent IVF to evaluate the effect of acupuncture on anti-mullerian hormone (AMH) and the effect on assisted reproduction outcome. It applied at certain acupoints according to the principles of traditional Chinese medicine.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 102 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Acupuncture Treatment Versus Non-acupuncture During IVF
Study Start Date : March 2011
Actual Primary Completion Date : March 2012
Actual Study Completion Date : May 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Acupuncture

Arm Intervention/treatment
Experimental: Acupuncture (Hwato®)
30-40 minutes acupuncture at certain acupoints that chosen according to traditional Chinese medicine and included LIV3,SP6,SP8,ST36,SP10,ST29,LI14,Ren 04;starting at follicular phase of the cycle till 2 days before oocyte picked up.
Device: Acupuncture(Hwato®)
acupuncture using 4cm long disposable stainless steel hair-thin needles manufactured by Suzhou medical appliance factory (China).

No Intervention: No acupuncture
No intervention was done for this group of patients.

Primary Outcome Measures :
  1. Clinical pregnancy rate. [ Time Frame: 13 months ]
    Increase in pregnancy rate

Secondary Outcome Measures :
  1. Ongoing pregnancy rate [ Time Frame: 15 months ]
    Increase in ongoing pregnancy rate

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria::

  • PCOS patients with patent one or two fallopian tubes, normal uterine cavity and partners with normal semen parameters.
  • infertility
  • 20-40 years
  • IVF treatment -

Exclusion Criteria:

  • patients with disorders that have the similar clinical presentation
  • closed both tubes
  • abnormal semen parameters
  • intracytoplasmic sperm injection (ICSI)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01778621

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China, Hubei
Assisted Reproduction Center, Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430022
Sponsors and Collaborators
Amina Altutunji
Huazhong University of Science and Technology
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Study Director: Ying Gao, Ph.D., M.D. Assisted Reproduction Center, Union Hospital

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Responsible Party: Amina Altutunji, Doctor /assissted reproduction center/Union Hospital, Huazhong University of Science and Technology Identifier: NCT01778621     History of Changes
Other Study ID Numbers: MINA-1978
First Posted: January 29, 2013    Key Record Dates
Last Update Posted: July 23, 2019
Last Verified: July 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Amina Altutunji, Huazhong University of Science and Technology: