Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER)

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Amgen
ClinicalTrials.gov Identifier:
NCT01764633
First received: January 8, 2013
Last updated: June 25, 2015
Last verified: June 2015
  Purpose

The primary hypothesis is that additional LDL-C lowering with Evolocumab (AMG 145) when used in addition to other treatment for dyslipidemia is well tolerated and decreases the risk of cardiovascular death, myocardial infarction, hospitalization for unstable angina, stroke, or coronary revascularization in subjects with clinically evident cardiovascular disease.


Condition Intervention Phase
Dyslipidemia
Biological: Evolocumab (AMG 145)
Other: Placebo
Drug: Effective statin therapy
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Additional LDL-Cholesterol Reduction on Major Cardiovascular Events When Evolocumab (AMG 145) is Used in Combination With Statin Therapy In Patients With Clinically Evident Cardiovascular Disease

Resource links provided by NLM:


Further study details as provided by Amgen:

Primary Outcome Measures:
  • Time to cardiovascular death, myocardial infarction, hospitalization for unstable angina, stroke, or coronary revascularization [ Time Frame: 5 years ] [ Designated as safety issue: Yes ]
    The primary endpoint is the time to cardiovascular death, myocardial infarction, hospitalization for unstable angina, stroke, or coronary revascularization, whichever occurs first.


Secondary Outcome Measures:
  • Time to cardiovascular death, myocardial infarction, or stroke [ Time Frame: 5 years ] [ Designated as safety issue: Yes ]
    Time to cardiovascular death, myocardial infarction, or stroke, whichever occurs first

  • Time to death by any cause [ Time Frame: 5 years ] [ Designated as safety issue: Yes ]
    Time to death by any cause

  • Time to cardiovascular death or hospitalization for worsening heart failure [ Time Frame: 5 years ] [ Designated as safety issue: Yes ]
    Time to cardiovascular death or hospitalization for worsening heart failure, whichever occurs first

  • Time to ischemic fatal or non-fatal stroke or TIA [ Time Frame: 5 years ] [ Designated as safety issue: Yes ]
    Time to ischemic fatal or non-fatal stroke or TIA, whichever occurs first


Enrollment: 27564
Study Start Date: January 2013
Estimated Study Completion Date: February 2018
Estimated Primary Completion Date: October 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm 1
Evolocumab (AMG 145) Q2W or QM plus effective statin dose
Biological: Evolocumab (AMG 145)
Evolocumab (AMG 145)
Drug: Effective statin therapy
Effective statin therapy defined as greater than or equal to atorvastatin 20 mg or an equivalent statin
Placebo Comparator: Arm 2
Placebo Q2W or QM plus effective statin dose
Other: Placebo
Placebo
Drug: Effective statin therapy
Effective statin therapy defined as greater than or equal to atorvastatin 20 mg or an equivalent statin

  Eligibility

Ages Eligible for Study:   40 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Male or female ≥ 40 to ≤ 85 years of age
  • History of clinically evident cardiovascular disease at high risk for a recurrent event
  • Fasting LDL-C ≥ 70 mg/dL (≥ 1.8 mmol/L) ) or non-HDL-C ≥ 100 mg/dL (> 2.6 mmol/L)
  • Fasting triglycerides ≤ 400 mg/dL (4.5 mmol/L)

Exclusion Criteria:

  • NYHA class III or IV, or last known left ventricular ejection fraction < 30%
  • Uncontrolled hypertension
  • Uncontrolled or recurrent ventricular tachycardia
  • Untreated hyperthyroidism or hypothyroidism
  • Homozygous familial hypercholesterolemia
  • LDL or plasma apheresis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01764633

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Brussels, Belgium, 1020
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Bruxelles, Belgium, 1200
Research Site
Gent, Belgium, 9000
Research Site
Gozee, Belgium, 6534
Research Site
Ieper, Belgium, 8900
Research Site
La Louviere, Belgium, 7100
Research Site
La Louvière, Belgium, 7100
Research Site
Liege, Belgium, 4000
Research Site
Liège, Belgium, 4000
Research Site
Lodelinsart, Belgium, 6042
Research Site
Natoye, Belgium, 5360
Research Site
Turnhout, Belgium, 2300
Brazil
Research Site
Fortaleza, Ceará, Brazil, 60430-350
Research Site
Brasília, Distrito Federal, Brazil, 71625-009
Research Site
Vitória, Espírito Santo, Brazil, 29042-751
Research Site
Goiania, Goiás, Brazil, 74223-130
Research Site
Belo Horizonte, Minas Gerais, Brazil, 30150-240
Research Site
Campina Grande do Sul, Paraná, Brazil, 83430-000
Research Site
Curitiba, Paraná, Brazil, 80010-030
Research Site
Curitiba, Paraná, Brazil, 80730-150
Research Site
Canoas, Rio Grande do Sul, Brazil, 92425-900
Research Site
Passo Fundo, Rio Grande do Sul, Brazil, 99010-080
Research Site
Porto Alegre, Rio Grande do Sul, Brazil, 90020-090
Research Site
Porto Alegre, Rio Grande do Sul, Brazil, 90035-001
Research Site
Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
Research Site
Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
Research Site
Porto Alegre, Rio Grande do Sul, Brazil, 91350-200
Research Site
Porto Alegre, Rio Grande do Sul, Brazil, 90880-480
Research Site
Porto Alegre, Rio Grande do Sul, Brazil, 90620-001
Research Site
Campinas, São Paulo, Brazil, 13010-001
Research Site
Campinas, São Paulo, Brazil, 13059-740
Research Site
Sao Jose do Rio Preto, São Paulo, Brazil, 15015-210
Research Site
Sao Paulo, São Paulo, Brazil, 01244-030
Research Site
Sao Paulo, São Paulo, Brazil, 04004-030
Research Site
Rio De Janeiro, Brazil, 22271-100
Research Site
São Paulo, Brazil, 04266-010
Research Site
São Paulo, Brazil, 05403-000
Research Site
São Paulo, Brazil, 04040-000
Bulgaria
Research Site
Haskovo, Bulgaria, 6300
Research Site
Kazanlak, Bulgaria, 6100
Research Site
Pazardzhik, Bulgaria, 4700
Research Site
Pleven, Bulgaria, 5800
Research Site
Plovdiv, Bulgaria, 4002
Research Site
Sofia, Bulgaria, 1309
Research Site
Sofia, Bulgaria, 1407
Research Site
Sofia, Bulgaria, 1431
Research Site
Sofia, Bulgaria, 1527
Research Site
Sofia, Bulgaria, 1606
Research Site
Sofia, Bulgaria, 1784
Research Site
Varna, Bulgaria, 9010
Canada, Alberta
Research Site
Calgary, Alberta, Canada, T2N 4Z6
Canada, British Columbia
Research Site
Kelowna, British Columbia, Canada, V1Y 1V6
Research Site
New Westminster, British Columbia, Canada, V3L 3W4
Research Site
Vancouver, British Columbia, Canada, V6Z 1Y6
Canada, Newfoundland and Labrador
Research Site
St. John's, Newfoundland and Labrador, Canada, A1A 3R5
Research Site
St. Johns, Newfoundland and Labrador, Canada, A1B 3V6
Canada, Nova Scotia
Research Site
Halifax, Nova Scotia, Canada, B3H 3A7
Canada, Ontario
Research Site
Brampton, Ontario, Canada, L6Z 4N5
Research Site
Cambridge, Ontario, Canada, N1R 6V6
Research Site
Hamilton, Ontario, Canada, L8L 2X2
Research Site
London, Ontario, Canada, N6A 5K8
Research Site
London, Ontario, Canada, N6C 0A7
Research Site
Newmarket, Ontario, Canada, L3Y 5G8
Research Site
Newmarket, Ontario, Canada, L3Y 8C3
Research Site
Oshawa, Ontario, Canada, L1J 2J9
Research Site
Oshawa, Ontario, Canada, L1J 2K1
Research Site
Ottawa, Ontario, Canada, K1Y 4W7
Research Site
Peterborough, Ontario, Canada, K9J 0B2
Research Site
Sarnia, Ontario, Canada, N7T 4X3
Research Site
Scarborough, Ontario, Canada, M1E 5E9
Research Site
Scarborough, Ontario, Canada, M1P 2T7
Research Site
Strathroy, Ontario, Canada, N7G 1Y7
Research Site
Thunder Bay, Ontario, Canada, P7B 6V4
Research Site
Toronto, Ontario, Canada, M5C 2T2
Research Site
Toronto, Ontario, Canada, M5T 3A9
Canada, Quebec
Research Site
Chicoutimi, Quebec, Canada, G7H 7K9
Research Site
Gatineau, Quebec, Canada, J8Y 6S9
Research Site
Granby, Quebec, Canada, J2G 8Z9
Research Site
Greenfield Park, Quebec, Canada, J4V 2G8
Research Site
Lachine, Quebec, Canada, H8S 2E4
Research Site
Longueuil, Quebec, Canada, J4M 2X1
Research Site
Montreal, Quebec, Canada, H2W 1T8
Research Site
Montreal, Quebec, Canada, H1Y 3L1
Research Site
Montreal, Quebec, Canada, H2W 1R7
Research Site
Montreal, Quebec, Canada, H3G 1A4
Research Site
Montreal, Quebec, Canada, H4A 3J1
Research Site
Montreal, Quebec, Canada, H1T 3Y7
Research Site
Pointe-Claire, Quebec, Canada, H9R 3J1
Research Site
Québec, Quebec, Canada, G1V 4G5
Research Site
St Jean sur Richelieu, Quebec, Canada, J3A 1C3
Research Site
St-Charles-Borromee, Quebec, Canada, J6E 6J2
Research Site
St-Jérôme, Quebec, Canada, J7Z 5T3
Research Site
Terrebonne, Quebec, Canada, J6V 2H2
Research Site
Westmout, Quebec, Canada, H3Z 1E5
Canada, Saskatchewan
Research Site
Regina, Saskatchewan, Canada, S4P 0W5
Canada
Research Site
Quebec, Canada, G1V 4M6
Chile
Research Site
Temuco, Cautín, Chile, 4813299
Research Site
Temuco, Cautín, Chile, 4781156
Research Site
Osorno, Chile, 5311092
Research Site
Santiago, Chile, 7500520
Research Site
Santiago, Chile, 7650018
Research Site
Santiago, Chile
Research Site
Santiago, Chile, 8350595
China, Beijing
Research Site
Beijing, Beijing, China, 100037
Research Site
Beijing, Beijing, China, 100191
China, Guangdong
Research Site
Guangzhou, Guangdong, China, 510080
China, Heilongjiang
Research Site
Harbin, Heilongjiang, China, 150001
China, Henan
Research Site
Zhengzhou, Henan, China, 450052
China, Hubei
Research Site
Wuhan, Hubei, China, 430030
Research Site
Wuhan, Hubei, China, 430014
China, Hunan
Research Site
Changde, Hunan, China, 415003
Research Site
Changsha, Hunan, China, 410013
Research Site
Changsha, Hunan, China, 410008
Research Site
Changsha, Hunan, China, 410005
Research Site
Changsha, Hunan, China, 410004
Research Site
Xiangtan, Hunan, China, 411100
Research Site
Zhuzhou, Hunan, China, 412000
China, Inner Mongolia
Research Site
Baotou, Inner Mongolia, China, 014010
Research Site
Hohhot, Inner Mongolia, China, 010020
China, Jiangsu
Research Site
Suzhou, Jiangsu, China, 215000
Research Site
Wuxi, Jiangsu, China, 214023
Research Site
Xuzhou, Jiangsu, China, 221006
China, Jilin
Research Site
Changchun, Jilin, China, 130011
Research Site
Changchun, Jilin, China, 130021
Research Site
Changchun, Jilin, China, 130033
Research Site
Siping, Jilin, China, 136000
China, Liaoning
Research Site
Dalian, Liaoning, China, 116027
Research Site
Shenyang, Liaoning, China, 110016
China, Ningxia
Research Site
Yinchuan, Ningxia, China, 750004
China, Shandong
Research Site
Qingdao, Shandong, China, 266003
China, Shanxi
Research Site
Taiyuan, Shanxi, China, 030009
China, Tianjin
Research Site
Tianjin, Tianjin, China, 300120
Research Site
Tianjin, Tianjin, China, 300052
China, Xinjiang
Research Site
Urumqi, Xinjiang, China, 830054
China, Zhejiang
Research Site
Hangzhou, Zhejiang, China, 310013
Research Site
Linhai, Zhejiang, China, 317000
Research Site
Ningbo, Zhejiang, China, 315010
Research Site
Wenzhou, Zhejiang, China, 325000
China
Research Site
Beijing, China, 100020
Research Site
Tianjin, China, 300211
Colombia
Research Site
Medellin, Antioquia, Colombia, 050012
Research Site
Medellin, Antioquia, Colombia, 050021
Research Site
Barranquilla, Atlántico, Colombia, 08001000
Research Site
Barranquilla, Atlántico, Colombia, 080020
Research Site
Cartagena, Bolívar, Colombia, 130010
Research Site
Manizales, Caldas, Colombia
Research Site
Bogota, Cundinamarca, Colombia, 11001000
Research Site
Bogota, Cundinamarca, Colombia, 110221
Research Site
Bogota, Cundinamarca, Colombia
Research Site
Armenia, Quindío, Colombia
Research Site
Santiago de Cali, Valle del Cauca, Colombia, 760032
Czech Republic
Research Site
Benatky nad Jizerou, Czech Republic, 294 71
Research Site
Benesov, Czech Republic, 256 01
Research Site
Beroun, Czech Republic, 266 01
Research Site
Bilovec, Czech Republic, 743 01
Research Site
Brandys nad Labem, Czech Republic, 250 01
Research Site
Brno, Czech Republic, 602 00
Research Site
Brno, Czech Republic, 603 00
Research Site
Brno, Czech Republic, 625 00
Research Site
Brno, Czech Republic, 636 00
Research Site
Brno, Czech Republic, 638 00
Research Site
Brno, Czech Republic, 656 91
Research Site
Ceske Budejovice, Czech Republic, 370 04
Research Site
Cesky Krumlov, Czech Republic, 381 01
Research Site
Chomutov, Czech Republic, 430 02
Research Site
Havlickuv Brod, Czech Republic, 580 22
Research Site
Hodonin, Czech Republic, 695 01
Research Site
Hradec Kralove, Czech Republic, 500 02
Research Site
Hranice na Morave, Czech Republic, 753 22
Research Site
Jihlava, Czech Republic, 586 01
Research Site
Kladno, Czech Republic, 272 59
Research Site
Klatovy IV, Czech Republic, 339 01
Research Site
Kutna Hora, Czech Republic, 284 01
Research Site
Liberec, Czech Republic, 460 63
Research Site
Litomerice, Czech Republic, 412 01
Research Site
Litomysl, Czech Republic, 570 14
Research Site
Milevsko, Czech Republic, 399 01
Research Site
Mlada Boleslav, Czech Republic, 293 01
Research Site
Mohelnice, Czech Republic, 789 85
Research Site
Moravske Budejovice, Czech Republic, 676 02
Research Site
Nymburk, Czech Republic, 288 01
Research Site
Olomouc, Czech Republic, 779 00
Research Site
Ostrava, Czech Republic, 728 80
Research Site
Ostrava - Vitkovice, Czech Republic, 703 00
Research Site
Ostrava-Poruba, Czech Republic, 708 00
Research Site
Pardubice, Czech Republic, 530 02
Research Site
Plzen, Czech Republic, 305 99
Research Site
Policka, Czech Republic, 572 01
Research Site
Prachatice, Czech Republic, 383 01
Research Site
Praha 10, Czech Republic, 101 00
Research Site
Praha 2, Czech Republic, 128 08
Research Site
Praha 3, Czech Republic, 130 00
Research Site
Praha 4, Czech Republic, 140 21
Research Site
Praha 4, Czech Republic, 140 59
Research Site
Praha 5, Czech Republic, 150 06
Research Site
Praha 5, Czech Republic, 158 00
Research Site
Praha 5 - Smichov, Czech Republic, 150 00
Research Site
Prerov, Czech Republic, 750 02
Research Site
Pribram VIII, Czech Republic, 261 01
Research Site
Svitavy, Czech Republic, 568 25
Research Site
Teplice, Czech Republic, 415 01
Research Site
Uherske Hradiste, Czech Republic, 686 01
Research Site
Znojmo, Czech Republic, 669 02
Denmark
Research Site
Aalborg, Denmark, 9000
Research Site
Aarhus N, Denmark, 8200
Research Site
Ballerup, Denmark, 2750
Research Site
Esbjerg, Denmark, 6700
Research Site
Glostrup, Denmark, 2600
Research Site
Hvidovre, Denmark, 2650
Research Site
København, Denmark, 2400
Research Site
København S, Denmark, 2300
Research Site
Køge, Denmark, 4600
Research Site
Odense, Denmark, 5000
Research Site
Roskilde, Denmark, 4000
Research Site
Svendborg, Denmark, 5700
Research Site
Vejle, Denmark, 7100
Research Site
Viborg, Denmark, 8800
Estonia
Research Site
Harjumaa, Estonia, 74001
Research Site
Paide, Estonia, 72713
Research Site
Tallinn, Estonia, 10128
Research Site
Tallinn, Estonia, 10138
Research Site
Tallinn, Estonia, 13419
Finland
Research Site
Helsinki, Finland, 00290
Research Site
Helsinki, Finland, 00180
Research Site
Hämeenlinna, Finland, 13100
Research Site
Jyväskylä, Finland, 40100
Research Site
Kokkola, Finland, 67100
Research Site
Kuopio, Finland, 70100
Research Site
Oulo, Finland, 90029
Research Site
Oulu, Finland, 90100
Research Site
Tampere, Finland, 33521
Research Site
Tampere, Finland, 33100
Research Site
Turku, Finland, 20100
France
Research Site
Besançon Cedex, France, 25030
Research Site
Brest Cedex 2, France, 29200
Research Site
Chambray les Tours, France, 37170
Research Site
Clermont Ferrand, France, 63000
Research Site
Créteil, France, 94010
Research Site
Dijon cedex, France, 21079
Research Site
Le Coudray, France, 28630
Research Site
Lille Cedex, France, 59037
Research Site
Lyon, France, 69007
Research Site
Marseille Cedex 08, France, 13285
Research Site
Metz cedex 03, France, 57085
Research Site
Montpellier cedex 05, France, 34295
Research Site
Montpellier cedex 5, France, 34094
Research Site
Nantes Cedex 1, France, 44093
Research Site
Nantes Cedex 2, France, 44202
Research Site
Nice, France, 06000
Research Site
Nimes, France, 30029
Research Site
Orleans, France, 45067
Research Site
Paris, France, 75013
Research Site
Paris, France, 75010
Research Site
Paris cedex 15, France, 75908
Research Site
Pau, France, 64000
Research Site
Perpignan Cedex, France, 66046
Research Site
Pessac Cedex, France, 33604
Research Site
Poitiers, France, 86000
Research Site
Reims cedex, France, 51092
Research Site
Rennes, France, 35033
Research Site
Saint Priest en Jarez, France, 42270
Research Site
Strasbourg, France, 67091
Research Site
Toulouse Cedex 9, France, 31059
Research Site
Vandoeuvre les Nancy, France, 54511
Research Site
Vesoul, France, 70014
Germany
Research Site
Bad Krozingen, Germany, 79189
Research Site
Berlin, Germany, 10787
Research Site
Berlin, Germany, 12351
Research Site
Berlin, Germany, 12559
Research Site
Berlin, Germany, 13353
Research Site
Bochum, Germany, 44787
Research Site
Demmin, Germany, 17109
Research Site
Dortmund, Germany, 44137
Research Site
Dresden, Germany, 01307
Research Site
Düsseldorf, Germany, 40210
Research Site
Frankfurt am Main, Germany, 60596
Research Site
Giessen, Germany, 35392
Research Site
Hamburg, Germany, 20099
Research Site
Hamburg, Germany, 20246
Research Site
Hannover, Germany, 30159
Research Site
Heidelberg, Germany, 69120
Research Site
Ingelheim, Germany, 55218
Research Site
Kassel, Germany, 34121
Research Site
Köln, Germany, 50937
Research Site
Lahr, Germany, 77933
Research Site
Leipzig, Germany, 04103
Research Site
Limburg, Germany, 65549
Research Site
Magdeburg, Germany, 39120
Research Site
Mainz, Germany, 55131
Research Site
Mannheim, Germany, 68165
Research Site
Marburg, Germany, 35043
Research Site
München, Germany, 80636
Research Site
München, Germany, 80638
Research Site
Regensburg, Germany, 93053
Research Site
Stuttgart, Germany, 70376
Research Site
Ulm, Germany, 89081
Research Site
Witten, Germany, 58455
Research Site
Wuppertal, Germany, 42117
Greece
Research Site
Alexandroupoli, Greece, 68100
Research Site
Athens, Greece, 12462
Research Site
Athens, Greece, 11521
Research Site
Athens, Greece, 11527
Research Site
Athens, Greece, 15123
Research Site
Athens, Greece, 14233
Research Site
Athens, Greece, 14561
Research Site
Athens, Greece, 16673
Research Site
Athens, Greece, 10676
Research Site
Athens, Greece, 17674
Research Site
Chalkida, Greece, 34100
Research Site
Heraklion, Greece, 71110
Research Site
Ioannina, Greece, 45500
Research Site
Larissa, Greece, 41110
Research Site
Nikaia, Piraeus, Greece, 18454
Research Site
Piraeus, Greece, 18536
Research Site
Rhodes, Greece, 85100
Research Site
Thessaloniki, Greece, 54642
Research Site
Thessaloniki, Greece, 54636
Hong Kong
Research Site
Hong Kong, Hong Kong
Research Site
New Territories, Hong Kong
Hungary
Research Site
Balatonfured, Hungary, 8230
Research Site
Bekescsaba, Hungary, 5600
Research Site
Berettyoujfalu, Hungary, 4100
Research Site
Budapest, Hungary, 1036
Research Site
Budapest, Hungary, 1125
Research Site
Budapest, Hungary, 1085
Research Site
Budapest, Hungary, 1096
Research Site
Budapest, Hungary, 1122
Research Site
Budapest, Hungary, 1027
Research Site
Budapest, Hungary, 1134
Research Site
Cegled, Hungary, 2700
Research Site
Debrecen, Hungary, 4032
Research Site
Gyongyos, Hungary, 3200
Research Site
Gyula, Hungary, 5700
Research Site
Kaposvar, Hungary, 7400
Research Site
Kecskemet, Hungary, 6000
Research Site
Komarom, Hungary, 2921
Research Site
Nyiregyhaza, Hungary, 4400
Research Site
Pecs, Hungary, 7624
Research Site
Szeged, Hungary, 6720
Research Site
Szekszard, Hungary, 7100
Research Site
Szikszo, Hungary, 3800
Research Site
Szolnok, Hungary, 5004
Research Site
Zalaegerszeg, Hungary, 8900
Iceland
Research Site
Kopavogur, Iceland, 201
Research Site
Reykjavik, Iceland, 101
India
Research Site
Vijayawada, Andhra Pradesh, India, 520 008
Research Site
New Delhi, Delhi, India, 110 002
Research Site
Ahmedabad, Gujarat, India, 380 008
Research Site
Ahmedabad, Gujarat, India, 380 016
Research Site
Ahmedabad, Gujarat, India, 380 054
Research Site
Ahmedabad, Gujarat, India, 380 060
Research Site
Vadodara, Gujarat, India, 390 001
Research Site
Gurgaon, Haryana, India, 122 001
Research Site
Belgaum, Karnataka, India, 590 010
Research Site
Mysore, Karnataka, India, 570 001
Research Site
Mumbai, Maharashtra, India, 400 022
Research Site
Mumbai, Maharashtra, India, 400 008
Research Site
Mumbai, Maharashtra, India, 400 007
Research Site
Nagpur, Maharashtra, India, 440 003
Research Site
Pune, Maharashtra, India, 411 005
Research Site
Pune, Maharashtra, India, 411 006
Research Site
Pune, Maharashtra, India, 411 019
Research Site
Lucknow, Uttar Pradesh, India, 226 003
Research Site
Kolkata, West Bengal, India, 700 020
Ireland
Research Site
Ballinasloe, Ireland
Research Site
Dublin, Ireland, 9
Research Site
Dublin, Ireland, 8
Research Site
Galway, Ireland
Israel
Research Site
Hadera, Israel, 38100
Research Site
Haifa, Israel, 31048
Research Site
Haifa, Israel, 34362
Research Site
Herzliya-on-sea, Israel, 46851
Research Site
Holon, Israel, 58100
Research Site
Jerusalem, Israel, 91031
Research Site
Nahariya, Israel, 22100
Research Site
Netanya, Israel, 42470
Research Site
Rehovot, Israel, 76100
Research Site
Tel Aviv, Israel, 64239
Research Site
Tel Hashomer, Israel, 52621
Italy
Research Site
Ascoli Piceno, Italy, 63100
Research Site
Bergamo, Italy, 24127
Research Site
Bologna, Italy, 40138
Research Site
Chieti, Italy, 66100
Research Site
Colleferro RM, Italy, 00034
Research Site
Cortona AR, Italy, 52044
Research Site
Firenze, Italy, 50139
Research Site
L' Aquila, Italy, 67100
Research Site
Milano, Italy, 20138
Research Site
Milano, Italy, 20162
Research Site
Napoli, Italy, 80131
Research Site
Palermo, Italy, 90126
Research Site
Parma, Italy, 43100
Research Site
Pavia, Italy, 27100
Research Site
Perugia, Italy, 06129
Research Site
Pisa, Italy, 56124
Research Site
Roma, Italy, 00168
Research Site
Roma, Italy, 00161
Research Site
Sanremo (IM), Italy, 18038
Research Site
Siena, Italy, 53100
Japan
Research Site
Ichinomiya-shi, Aichi, Japan, 491-8551
Research Site
Kasugai-shi, Aichi, Japan, 487-0031
Research Site
Nagoya-shi, Aichi, Japan, 460-0001
Research Site
Nagoya-shi, Aichi, Japan, 455-8530
Research Site
Nagoya-shi, Aichi, Japan, 451-8511
Research Site
Nagoya-shi, Aichi, Japan, 457-8511
Research Site
Toyohashi-shi, Aichi, Japan, 440-8510
Research Site
Chiba-shi, Chiba, Japan, 260-8606
Research Site
Matsudo-shi, Chiba, Japan, 271-0077
Research Site
Niihama-shi, Ehime, Japan, 792-8586
Research Site
Saijo-shi, Ehime, Japan, 793-0030
Research Site
Chikushi-gun, Fukuoka, Japan, 811-1244
Research Site
Chikushino-shi, Fukuoka, Japan, 818-8516
Research Site
Fukuoka-shi, Fukuoka, Japan, 814-0180
Research Site
Fukuoka-shi, Fukuoka, Japan, 814-8522
Research Site
Itoshima-shi, Fukuoka, Japan, 819-1104
Research Site
Koga-shi, Fukuoka, Japan, 811-3195
Research Site
Kurume-shi, Fukuoka, Japan, 830-8577
Research Site
Kurume-shi, Fukuoka, Japan, 830-0011
Research Site
Okawa-shi, Fukuoka, Japan, 831-0016
Research Site
Koriyama-shi, Fukushima, Japan, 963-8052
Research Site
Kure-shi, Hiroshima, Japan, 737-0023
Research Site
Otake-shi, Hiroshima, Japan, 739-0651
Research Site
Asahikawa-shi, Hokkaido, Japan, 070-0054
Research Site
Sapporo-shi, Hokkaido, Japan, 060-0031
Research Site
Himeji-shi, Hyogo, Japan, 672-8043
Research Site
Kobe-shi, Hyogo, Japan, 654-0155
Research Site
Toride-shi, Ibaraki, Japan, 302-0022
Research Site
Tsukuba-city, Ibaraki, Japan, 305-8558
Research Site
Kanazawa-shi, Ishikawa, Japan, 920-8650
Research Site
Sanuki-shi, Kagawa, Japan, 769-2393
Research Site
Fujisawa-shi, Kanagawa, Japan, 251-8550
Research Site
Odawara-shi, Kanagawa, Japan, 250-8558
Research Site
Sagamihara-shi, Kanagawa, Japan, 252-0375
Research Site
Yokohama-shi, Kanagawa, Japan, 245-8575
Research Site
Kumamoto-shi, Kumamoto, Japan, 860-8556
Research Site
Kyoto-shi, Kyoto, Japan, 615-0035
Research Site
Sendai-shi, Miyagi, Japan, 983-8520
Research Site
Higashisonogi-gun, Nagasaki, Japan, 859-3615
Research Site
Nagasaki-shi, Nagasaki, Japan, 850-8555
Research Site
Omura-shi, Nagasaki, Japan, 856-8562
Research Site
Oita-shi, Oita, Japan, 870-0263
Research Site
Okayama-shi, Okayama, Japan, 702-8055
Research Site
Okinawa-shi, Okinawa, Japan, 904-8585
Research Site
Shimajiri-gun, Okinawa, Japan, 901-0493
Research Site
Urasoe-shi, Okinawa, Japan, 901-2132
Research Site
Osaka-shi, Osaka, Japan, 550-0022
Research Site
Osaka-shi, Osaka, Japan, 530-8480
Research Site
Osaka-shi, Osaka, Japan, 543-0035
Research Site
Osaka-shi, Osaka, Japan, 530-0001
Research Site
Saga-shi, Saga, Japan, 840-8571
Research Site
Saga-shi, Saga, Japan, 849-0917
Research Site
Kawaguchi-shi, Saitama, Japan, 332-8558
Research Site
Kusatsu-shi, Shiga, Japan, 525-8585
Research Site
Hamada-shi, Shimane, Japan, 697-8511
Research Site
Sunto-gun, Shizuoka, Japan, 411-8611
Research Site
Komatsushima-shi, Tokushima, Japan, 773-8502
Research Site
Bunkyo-ku, Tokyo, Japan, 113-8431
Research Site
Chuo-ku, Tokyo, Japan, 103-0027
Research Site
Hachioji-shi, Tokyo, Japan, 192-0918
Research Site
Itabashi-ku, Tokyo, Japan, 173-8606
Research Site
Itabashi-ku, Tokyo, Japan, 173-8610
Research Site
Musashimurayama-shi, Tokyo, Japan, 208-0011
Research Site
Tachikawa-shi, Tokyo, Japan, 190-0014
Research Site
Chuo-shi, Yamanashi, Japan, 409-3898
Korea, Republic of
Research Site
Busan, Seo-gu, Korea, Republic of, 602-715
Research Site
Daegu, Korea, Republic of, 130-702
Research Site
Daejeon, Korea, Republic of, 371-718
Research Site
Daejeon, Korea, Republic of, 301-723
Research Site
Goyang-si, Gyeonggi-do, Korea, Republic of, 411-706
Research Site
Gwangju, Korea, Republic of, 501-757
Research Site
Seongnam-si, Korea, Republic of, 463-707
Research Site
Seoul, Korea, Republic of, 158-710
Research Site
Seoul, Korea, Republic of, 110-746
Research Site
Seoul, Korea, Republic of, 135-700
Research Site
Seoul, Korea, Republic of, 135-710
Research Site
Seoul, Korea, Republic of, 137-701
Research Site
Seoul, Korea, Republic of, 138-736
Research Site
Seoul, Korea, Republic of, 152-703
Research Site
Seoul, Korea, Republic of, 156-707
Research Site
Seoul, Korea, Republic of, 120-752
Research Site
Suwon-si, Korea, Republic of, 443-380
Latvia
Research Site
Daugavpils, Latvia, 5417
Research Site
Daugavpils, Latvia, LV-5410
Research Site
Kuldiga, Latvia, LV-3301
Research Site
Liepaja, Latvia, LV-3414
Research Site
Ogre, Latvia, 5001
Research Site
Ogre, Latvia, LV-5003
Research Site
Riga, Latvia, 1002
Research Site
Riga, Latvia, 1012
Research Site
Riga, Latvia, LV-1001
Lithuania
Research Site
Kaunas, Lithuania, 50009
Research Site
Kaunas, Lithuania, 48259
Research Site
Klaipeda, Lithuania, 94231
Research Site
Vilnius, Lithuania, 08861
Research Site
Vilnius, Lithuania, 08661
Research Site
Vilnius, Lithuania, 10323
Malaysia
Research Site
Johor Bahru, Johor, Malaysia, 80100
Research Site
Taiping, Perak, Malaysia, 34000
Research Site
Kota Kinabalu, Sabah, Malaysia, 88300
Research Site
Kuala Lumpur, Wilayah Persekutuan, Malaysia, 50400
Research Site
Kuala Lumpur, Wilayah Persekutuan, Malaysia, 56000
Research Site
Georgetown, Malaysia, 10400
Research Site
Kuala Lumpur, Malaysia, 59100
Research Site
Melaka, Malaysia, 75400
Research Site
Penang, Malaysia, 10050
Mexico
Research Site
Torreon, Coahuila, Mexico, 27000
Research Site
Mexico, Distrito Federal, Mexico, 14380
Research Site
Mexico, Distrito Federal, Mexico, 03800
Research Site
Leon, Guanajuato, Mexico, 37520
Research Site
Guadalajara, Jalisco, Mexico, 44600
Research Site
Guadalajara, Jalisco, Mexico, 44150
Research Site
Guadalajara, Jalisco, Mexico, 44210
Research Site
Guadalajara, Jalisco, Mexico, 44380
Research Site
Guadalajara, Jalisco, Mexico, 44340
Research Site
Monterrey, Nuevo León, Mexico, 64718
Research Site
Queretaro, Querétaro, Mexico, 76000
Research Site
San Luis Potosi, San Luis Potosí, Mexico, 78240
Research Site
Culiacan, Sinaloa, Mexico, 80020
Research Site
Tampico, Tamaulipas, Mexico, 89000
Research Site
Xalapa, Veracruz, Mexico, 91193
Research Site
Aguascalientes, Mexico, 20230
Research Site
Chihuahua, Mexico, 31217
Netherlands
Research Site
Alkmaar, Netherlands, 1815 JD
Research Site
Almelo, Netherlands, 7609 PP
Research Site
Amstelveen, Netherlands, 1186 AM
Research Site
Amsterdam, Netherlands, 1061 AE
Research Site
Amsterdam, Netherlands, 1091 AC
Research Site
Arnhem, Netherlands, 6815 AD
Research Site
Beverwijk, Netherlands, 1942 LE
Research Site
Den Helder, Netherlands, 1782 GZ
Research Site
Deventer, Netherlands, 7416 SE
Research Site
Doetinchem, Netherlands, 7009 BL
Research Site
Ede, Netherlands, 6716 RP
Research Site
Eindhoven, Netherlands, 5623 EJ
Research Site
Eindhoven, Netherlands, 5631 BM
Research Site
Goes, Netherlands, 4462 RA
Research Site
Gorinchem, Netherlands, 4204 AA
Research Site
Gouda, Netherlands, 2803 HH
Research Site
Harderwijk, Netherlands, 3844 DG
Research Site
Helmond, Netherlands, 5707 HA
Research Site
Hoogeveen, Netherlands, 7909 AA
Research Site
Hoorn, Netherlands, 1625 HV
Research Site
Leiden, Netherlands, 2334 CK
Research Site
Leiden, Netherlands, 2333 ZA
Research Site
Nieuwegein, Netherlands, 3435 CM
Research Site
Nijmegen, Netherlands, 6532 SZ
Research Site
Purmerend, Netherlands, 1440 AG
Research Site
Rotterdam, Netherlands, 3045 PM
Research Site
Rotterdam, Netherlands, 3079 DZ
Research Site
Sneek, Netherlands, 8601 ZK
Research Site
Tiel, Netherlands, 4002 WP
Research Site
Tilburg, Netherlands, 5042 AD
Research Site
Uden, Netherlands, 5406 PT
Research Site
Veldhoven, Netherlands, 5504 DB
Research Site
Venlo, Netherlands, 5912 BL
New Zealand
Research Site
Christchurch, New Zealand, 8011
Research Site
Papatoetoe, Auckland, New Zealand, 2025
Research Site
Tauranga, New Zealand, 3143
Norway
Research Site
Bekkestua, Norway, 1357
Research Site
Bodø, Norway, 8092
Research Site
Hamar, Norway, 2317
Research Site
Lierskogen, Norway, 3420
Research Site
Oslo, Norway, 0450
Research Site
Skedsmokorset, Norway, 2020
Research Site
Skien, Norway, 3710
Research Site
Stavanger, Norway, 4005
Research Site
Ålesund, Norway, 6003
Philippines
Research Site
Davao City, Davao, Philippines, 8000
Research Site
Angeles, Philippines, 2009
Research Site
Baguio City, Philippines, 2600
Research Site
Dasmariñas Cavite, Philippines, 4114
Research Site
Iloilo, Philippines, 5000
Research Site
Makati City, Philippines, 1218
Research Site
Manila, Philippines, 1113
Research Site
Marikiina, Philippines, 1800
Research Site
Quezon City, Philippines, 1100
Research Site
Quezon City, Philippines, 1102
Poland
Research Site
Bielsko-Biala, Poland, 43-316
Research Site
Bydgoszcz, Poland, 85-094
Research Site
Gdansk, Poland, 80-542
Research Site
Gdansk, Poland, 80-952
Research Site
Gdynia, Poland, 81-472
Research Site
Gdynia, Poland, 81-402
Research Site
Gdynia, Poland, 81-384
Research Site
Gizycko, Poland, 11-500
Research Site
Jelenia Gora, Poland, 58-506
Research Site
Katowice, Poland, 40-018
Research Site
Katowice, Poland, 40-040
Research Site
Katowice, Poland, 40-084
Research Site
Kielce, Poland, 25-020
Research Site
Krakow, Poland, 30-001
Research Site
Krakow, Poland, 30-347
Research Site
Krakow, Poland, 31-202
Research Site
Krakow, Poland, 31-315
Research Site
Krakow, Poland, 32-082
Research Site
Krakow, Poland, 31-216
Research Site
Lodz, Poland, 93-530
Research Site
Lodz, Poland, 90-368
Research Site
Lodz, Poland, 90-549
Research Site
Lodz, Poland, 91-347
Research Site
Lublin, Poland, 20-080
Research Site
Lublin, Poland, 20-857
Research Site
Lublin, Poland, 20-045
Research Site
Nowa Sol, Poland, 67-100
Research Site
Nysa, Poland, 48-300
Research Site
Olsztyn, Poland, 10-010
Research Site
Plock, Poland, 09-402
Research Site
Poznan, Poland, 61-853
Research Site
Poznan, Poland, 61-113
Research Site
Poznan, Poland, 60-702
Research Site
Pszczyna, Poland, 43-200
Research Site
Pulawy, Poland, 24-100
Research Site
Ruda Slaska, Poland, 41-710
Research Site
Skierniewice, Poland, 96-100
Research Site
Starogard Gdanski, Poland, 83-200
Research Site
Staszow, Poland, 28-200
Research Site
Swidnik, Poland, 21-040
Research Site
Tarnow, Poland, 33-100
Research Site
Torun, Poland, 87-100
Research Site
Warszawa, Poland, 01-192
Research Site
Warszawa, Poland, 04-628
Research Site
Warszawa, Poland, 02-097
Research Site
Warszawa, Poland, 02-507
Research Site
Warszawa, Poland, 04-730
Research Site
Warszawa, Poland, 04-749
Research Site
Warszawa, Poland, 01-809
Research Site
Wloclawek, Poland, 87-800
Research Site
Wroclaw, Poland, 51-685
Research Site
Wroclaw, Poland, 50-088
Research Site
Wroclaw, Poland, 50-349
Research Site
Zamosc, Poland, 22-400
Portugal
Research Site
Almada, Portugal, 2801-951
Research Site
Amadora, Portugal, 2720-276
Research Site
Carnaxide, Portugal, 2790-134
Research Site
Coimbra, Portugal, 3000-075
Research Site
Covilha, Portugal, 6200-251
Research Site
Lisboa, Portugal, 1169-024
Research Site
Lisboa, Portugal, 1449-005
Research Site
Lisboa, Portugal, 1350-070
Research Site
Porto, Portugal, 4100-180
Research Site
Setubal, Portugal, 2910-446
Romania
Research Site
Bucharest, Romania, 010242
Research Site
Bucharest, Romania, 011601
Research Site
Bucharest, Romania, 020125
Research Site
Bucuresti, Romania, 042122
Research Site
Bucuresti, Romania, 021659
Research Site
Bucuresti, Romania, 030463
Research Site
Bucuresti, Romania, 020054
Research Site
Cluj-Napoca, Romania, 400347
Research Site
Craiova, Romania, 200147
Research Site
Iasi, Romania, 700503
Research Site
Iasi, Romania, 700547
Research Site
Iasi, Romania, 700661
Research Site
Oradea, Romania, 410169
Research Site
Timisoara, Romania, 300158
Research Site
Timisoara, Romania, 300079
Research Site
Timisoara, Romania, 300736
Russian Federation
Research Site
Barnaul, Russian Federation, 656038
Research Site
Barnaul, Russian Federation, 656055
Research Site
Ekaterinburg, Russian Federation, 620144
Research Site
Ekaterinburg, Russian Federation, 620102
Research Site
Ivanovo, Russian Federation, 153012
Research Site
Izhevsk, Russian Federation, 426063
Research Site
Kemerovo, Russian Federation, 650002
Research Site
Kemerovo, Russian Federation, 650099
Research Site
Kirov, Russian Federation, 610014
Research Site
Moscow, Russian Federation, 121552
Research Site
Moscow, Russian Federation, 101990
Research Site
Moscow, Russian Federation, 111539
Research Site
Moscow, Russian Federation, 117292
Research Site
Moscow, Russian Federation, 117485
Research Site
Moscow, Russian Federation, 119620
Research Site
Moscow, Russian Federation, 129090
Research Site
Moscow, Russian Federation, 111020
Research Site
Nizhniy Novgorod, Russian Federation, 603076
Research Site
Novosibirsk, Russian Federation, 630047
Research Site
Novosibirsk, Russian Federation, 630089
Research Site
Omsk, Russian Federation, 644018
Research Site
Pushkin, Russian Federation, 196601
Research Site
Saint Petersburg, Russian Federation, 197341
Research Site
Saint Petersburg, Russian Federation, 197022
Research Site
Saint Petersburg, Russian Federation, 198205
Research Site
Saint Petersburg, Russian Federation, 195112
Research Site
Saint-Petersburg, Russian Federation, 194156
Research Site
Saint-Petersburg, Russian Federation, 192288
Research Site
Saint-Petersburg, Russian Federation, 199106
Research Site
Saratov, Russian Federation, 410054
Research Site
St. Petersburg, Russian Federation, 191015
Research Site
Tomsk, Russian Federation, 634012
Research Site
Tyumen, Russian Federation, 625000
Singapore
Research Site
Singapore, Singapore, 169609
Research Site
Singapore, Singapore, 529889
Research Site
Singapore, Singapore, 768828
Slovakia
Research Site
Banovce nad Bebravou, Slovakia, 957 01
Research Site
Bardejov, Slovakia, 085 01
Research Site
Bratislava, Slovakia, 833 48
Research Site
Bratislava, Slovakia, 833 31
Research Site
Bratislava, Slovakia, 811 04
Research Site
Brezno, Slovakia, 977 42
Research Site
Dolny Kubin, Slovakia, 026 01
Research Site
Kosice, Slovakia, 040 22
Research Site
Kosice, Slovakia, 040 01
Research Site
Lucenec, Slovakia, 984 01
Research Site
Martin, Slovakia, 036 59
Research Site
Moldava nad Bodvou, Slovakia, 045 01
Research Site
Nitra, Slovakia, 949 01
Research Site
Nove Zamky, Slovakia, 940 01
Research Site
Presov, Slovakia, 080 01
Research Site
Rimavska Sobota, Slovakia, 979 01
Research Site
Roznava, Slovakia, 048 01
Research Site
Snina, Slovakia, 069 01
Research Site
Svidnik, Slovakia, 08901
Research Site
Trencin, Slovakia, 911 01
Research Site
Trnava, Slovakia, 917 01
South Africa
Research Site
Port Elizabeth, Eastern Cape, South Africa, 6001
Research Site
Bloemfontein, Free State, South Africa, 9301
Research Site
Alberton, Gauteng, South Africa, 1449
Research Site
Alberton, Gauteng, South Africa, 1450
Research Site
Boksburg, Gauteng, South Africa, 1459
Research Site
Johannesburg, Gauteng, South Africa, 1724
Research Site
Johannesburg, Gauteng, South Africa, 2157
Research Site
Johannesburg, Gauteng, South Africa, 2193
Research Site
Johannesburg, Gauteng, South Africa, 2196
Research Site
Lyttelton, Gauteng, South Africa, 0140
Research Site
Midrand, Gauteng, South Africa, 1685
Research Site
Pretoria, Gauteng, South Africa, 0184
Research Site
Pretoria, Gauteng, South Africa, 0040
Research Site
Pretoria, Gauteng, South Africa, 0087
Research Site
Pretoria, Gauteng, South Africa, 0158
Research Site
Pretoria west, Gauteng, South Africa, 0183
Research Site
Soweto, Gauteng, South Africa, 2013
Research Site
Amanzimtoti, KwaZulu-Natal, South Africa, 4126
Research Site
Durban, KwaZulu-Natal, South Africa, 4321
Research Site
Durban, KwaZulu-Natal, South Africa, 4001
Research Site
Tongaat, KwaZulu-Natal, South Africa, 4400
Research Site
Kuils River, Western Cape, South Africa, 7580
Research Site
Paarl, Western Cape, South Africa, 7646
Research Site
Parow, Western Cape, South Africa, 7505
Research Site
Somerset West, Western Cape, South Africa, 7130
Research Site
Worcester, Western Cape, South Africa, 6850
Research Site
Cape Town, South Africa, 7405
Research Site
Cape Town, South Africa, 7530
Research Site
Kempton Park, South Africa, 1619
Spain
Research Site
Almeria, Andalucía, Spain, 04120
Research Site
Cordoba, Andalucía, Spain, 14004
Research Site
Zaragoza, Aragón, Spain, 50009
Research Site
L'Hospitalet de Llobregat, Cataluña, Spain, 08907
Research Site
San Juan de Alicante, Comunidad Valenciana, Spain, 03550
Research Site
Valencia, Comunidad Valenciana, Spain, 46010
Research Site
Santiago de Compostela, Galicia, Spain, 15706
Research Site
Vigo, Galicia, Spain, 36200
Research Site
El Palmar, Murcia, Spain, 30120
Research Site
Galdakao, País Vasco, Spain, 48960
Research Site
Madrid, Spain, 28007
Research Site
Madrid, Spain, 28034
Sweden
Research Site
Bollnäs, Sweden, 821 81
Research Site
Eksjö, Sweden, 575 81
Research Site
Eskilstuna, Sweden, 631 88
Research Site
Falun, Sweden, 791 82
Research Site
Helsingborg, Sweden, 251 87
Research Site
Jönköping, Sweden, 551 85
Research Site
Linköping, Sweden, 581 85
Research Site
Luleå, Sweden, 971 80
Research Site
Lund, Sweden, 221 85
Research Site
Lund, Sweden, 222 21
Research Site
Stockholm, Sweden, 141 86
Research Site
Stockholm, Sweden, 118 83
Research Site
Stockholm, Sweden, 111 35
Research Site
Stockholm, Sweden, 171 76
Research Site
Uddevalla, Sweden, 451 50
Research Site
Umeå, Sweden, 901 85
Research Site
Västerås, Sweden, 721 89
Research Site
Örebro, Sweden, 701 85
Research Site
Östersund, Sweden, 831 83
Switzerland
Research Site
Baden, Switzerland, 5404
Research Site
Basel, Switzerland, 4031
Research Site
Bern, Switzerland, 3010
Research Site
Geneva 14, Switzerland, 1211
Research Site
Lausanne, Switzerland, 1011
Research Site
Lugano, Switzerland, 6900
Research Site
Sion, Switzerland, 1950
Research Site
Winterthur, Switzerland, 8401
Research Site
Zurich, Switzerland, 8063
Taiwan
Research Site
New Taipei City, Taipei, Taiwan, 251
Research Site
Changhua, Taiwan, 50006
Research Site
Kaohsiung, Taiwan, 83301
Research Site
Kaohsiung, Taiwan, 807
Research Site
Taichung City, Taiwan, 402
Research Site
Tainan, Taiwan, 710
Research Site
Taipei, Taiwan, 11217
Research Site
Taipei, Taiwan, 10630
Research Site
Taipei, Taiwan, 10002
Research Site
Taoyuan, Taiwan, 33305
Turkey
Research Site
Adana, Turkey, 01330
Research Site
Ankara, Turkey, 06100
Research Site
Ankara, Turkey, 06490
Research Site
Gaziantep, Turkey, 27310
Research Site
Istanbul, Turkey, 34662
Research Site
Istanbul, Turkey, 34865
Research Site
Istanbul, Turkey, 34096
Research Site
Izmir, Turkey, 35000
Research Site
Izmir, Turkey, 35100
Research Site
Kocaeli, Turkey, 41380
Research Site
Konya, Turkey, 42080
Research Site
Samsun, Turkey, 55139
Research Site
Sivas, Turkey, 58140
Ukraine
Research Site
Cherkasy, Ukraine, 18009
Research Site
Ivano-Frankivsk, Ukraine, 76018
Research Site
Kharkiv, Ukraine, 61106
Research Site
Kharkiv, Ukraine, 61039
Research Site
Kharkiv, Ukraine, 61018
Research Site
Kharkiv, Ukraine, 61176
Research Site
Kharkiv, Ukraine, 61002
Research Site
Kyiv, Ukraine, 04114
Research Site
Kyiv, Ukraine, 01023
Research Site
Kyiv, Ukraine, 02091
Research Site
Kyiv, Ukraine, 02232
Research Site
Kyiv, Ukraine, 02660
Research Site
Kyiv, Ukraine, 02002
Research Site
Kyiv, Ukraine, 03680
Research Site
Kyiv, Ukraine, 03049
Research Site
Lugansk, Ukraine, 91045
Research Site
Uzhgorod, Ukraine, 88000
Research Site
Vinnytsia, Ukraine, 21018
Research Site
Vinnytsia, Ukraine, 21029
Research Site
Zaporizhzhia, Ukraine, 69035
Research Site
Zaporizhzhia, Ukraine, 69000
Research Site
Zaporizhzhya, Ukraine, 69600
United Kingdom
Research Site
Aberdeen, United Kingdom, AB25 2ZN
Research Site
Addlestone, United Kingdom, KT15 2BH
Research Site
Arnsley, United Kingdom, S75 2EP
Research Site
Basildon, United Kingdom, SS16 5NL
Research Site
Belfast, United Kingdom, BT12 6BA
Research Site
Belfast, United Kingdom, BT7 2EB
Research Site
Belfast, United Kingdom, BT16 1RH
Research Site
Belfast, United Kingdom, BT13 3BW
Research Site
Birmingham, United Kingdom, B18 7QH
Research Site
Birmingham, United Kingdom, B15 2SQ
Research Site
Blackpool, United Kingdom, FY3 8NR
Research Site
Bournemouth, United Kingdom, BH7 7DW
Research Site
Bury St Edmunds, United Kingdom, IP33 2QZ
Research Site
Canterbury, United Kingdom, CT1 3NG
Research Site
Cardiff, United Kingdom, CF14 5GJ
Research Site
Cardiff, United Kingdom, CF4 4XW
Research Site
Chesterfield, United Kingdom, S40 4AA
Research Site
Chippenham, United Kingdom, SN15 2SB
Research Site
Chorley, United Kingdom, PR7 7NA
Research Site
Colchester, United Kingdom, CO4 5JL
Research Site
Cottingham, United Kingdom, HU16 5JQ
Research Site
Coventry, United Kingdom, CV4 7AL
Research Site
Dundee, United Kingdom, DD1 9SY
Research Site
Edinburgh, United Kingdom, EH16 4SB
Research Site
Glasgow, United Kingdom, G45 9AW
Research Site
Glasgow, United Kingdom, G20 0SP
Research Site
Glasgow, United Kingdom, G51 4TF
Research Site
Harrow, United Kingdom, HA1 3UJ
Research Site
Haxey, Doncaster, United Kingdom, DN9 2HY
Research Site
Hayle, United Kingdom, TR27 5DT
Research Site
Hexham, United Kingdom, NE46 1QJ
Research Site
Hitchin, United Kingdom, SG4 9TH
Research Site
Inverness, United Kingdom, IV2 3JH
Research Site
Leamington Spa, United Kingdom, CV34 4RA
Research Site
Leeds, United Kingdom, LS1 3EX
Research Site
Leicester, United Kingdom, LE3 9QP
Research Site
Liverpool, United Kingdom, L22 0LG
Research Site
Liverpool, United Kingdom, L7 8XP
Research Site
Liverpool, United Kingdom, L9 7AL
Research Site
London, United Kingdom, EC1M 6BQ
Research Site
London, United Kingdom, SE1 7EH
Research Site
London, United Kingdom, W12 0HS
Research Site
Luton, United Kingdom, LU4 0DZ
Research Site
Manchester, United Kingdom, M15 6SX
Research Site
Manchester, United Kingdom, M23 9LT
Research Site
Middlesbrough, United Kingdom, TS4 3BW
Research Site
Newport, United Kingdom, PO30 5TG
Research Site
Northampton, United Kingdom, NN1 5BD
Research Site
Nottingham, United Kingdom, NG5 1PB
Research Site
Nuneaton, United Kingdom, CV10 7DJ
Research Site
Penzance, United Kingdom, TR18 2RE
Research Site
Penzance, United Kingdom, TR18 4EL
Research Site
Penzance, United Kingdom, TR19 7HX
Research Site
Plymouth, United Kingdom, PL6 8DH
Research Site
Portsmouth, United Kingdom, PO6 3LY
Research Site
Reading, United Kingdom, RG2 0TG
Research Site
Rotherham, United Kingdom, S60 2UD
Research Site
Rugby, United Kingdom, CV22 5PX
Research Site
Sandbach, United Kingdom, CW11 1EQ
Research Site
Sheffield, United Kingdom, S5 7AU
Research Site
St Austell, United Kingdom, PL26 7RL
Research Site
St. Leonards-on-Sea, United Kingdom, TN37 7RD
Research Site
Stevenage, United Kingdom, SG1 4AB
Research Site
Stoke-on-Trent, United Kingdom, ST4 6DG
Research Site
Swansea, United Kingdom, SA2 8PP
Research Site
Telford, United Kingdom, TF1 6TF
Research Site
Torquay, United Kingdom, TQ2 7AA
Research Site
Welwyn Garden City, United Kingdom, AL7 4HQ
Research Site
West Bromwich, United Kingdom, B71 4HJ
Research Site
Whitby, United Kingdom, YO21 1SD
Research Site
Wiltshire, United Kingdom, BA15 1DQ
Research Site
Wirral, United Kingdom, CH49 5PE
Research Site
Wolverhampton, United Kingdom, WV10 0QP
Research Site
Worcester, United Kingdom, WR5 1DD
Research Site
Wrexham, United Kingdom, LL13 7TD
Research Site
York, United Kingdom, YO31 8HE
Sponsors and Collaborators
Amgen
Investigators
Study Director: MD Amgen
  More Information

Additional Information:
No publications provided

Responsible Party: Amgen
ClinicalTrials.gov Identifier: NCT01764633     History of Changes
Other Study ID Numbers: 20110118, 2014/01/004324
Study First Received: January 8, 2013
Last Updated: June 25, 2015
Health Authority: Argentina: ANMAT (Administración Nacional de Medicamentos, Alimentos y Tecnología Medica)
Brazil: ANVISA (Agencia Nacional de Vigilancia Sanitária)
Hong Kong: Department of Health
Phillipines: Food and Drug Administration
Malaysia: Ministry of Health
Singapore: Health Sciences Authority
South Korea: Korea Food & Drug Administration
Taiwan: Taiwan Food and Drug Administration
Czech Republic: State Institute for Drug Control (SUKL)
Hungary: National Institute for Quality and Organizational Development in Healthcare and Medicines, National Institute of Pharmacy Directorate Clinical Trials Department
Poland: The office for registration of Medicinal Products, Medical Devices and Biocides
Slovakia: SUKL
Australia: Therapeutic Goods Administration (TGA)
France: Agence Nationale de Sécurité du Médicament et des produits de santé
Germany: Paul-Ehrlich-Institut
New Zealand: MEDSAFE (New Zealand Medicines and Medical Devices Safety Authority)
Spain: Agencia Española de Medicamentos y Productos Sanitarios
Canada: Canadian Agency is Health Canada _ Biologics and Genetic Therapies Directorate.
United States: Food and Drug Administration
Belgium: Federal Agency for Medicines and Health Products, FAMHP
Denmark: Danish Health and Medicines Authority (Sundhedsstyrelsen)
Estonia: State Agency of Medicines (Ravimiamet)
Finland: Finnish Medicines Agency (Fimea)
Greece: National Drug Organization (EOF)
Iceland: Icelandic Medicines Agency (Lyfjastofnun)
Ireland: Irish Medicines Board
Latvia: State Agency of Medicines (Zāļu valsts aģentūra)
Lithuania: State Medicines Control Agency (Valstybinė vaistų kontrolės tarnyba prie Lietuvos Respublikos sveikatos apsaugos ministerijos)
Netherlands: Centrale Commissie Mensgebonden Onderzoek (CCMO
Norway: Norwegian Medicines Agency (Statens legemiddelverk)
South Africa: MCC
Sweden: Medical Products Agency (Läkemedelsverket)
Switzerland: Swissmedic
United Kingdom: Medicines and Healthcare Products Regulatory Agency
Bulgara: Bulgarian Drug Agency
Romania: Ministry of Health, National Agency for Medicines and Medical Devices
Ukraine: State Expert Center of the Ministry of Health of Ukraine
Turkey: Ministry of Health, the Republic of Turkey
Chile: Instituto de Salud Pública
Mexico: Federal Commission for the Protection Against Sanitary Risks Sanitary of Health Agency
Israel: Israel Ministry of Health
Portugal: INFARMED, Autoridade Nacional do Medicamento e Produtos de Saúde I.P.
Russia: The Ministry of Healthcare of the Russian Federation
Austria: Bundesamt für Sicherheit im Gesundheitswesen-AGES Medizinmarktaufsicht-Institut Zulassung & LifeCycleManagement (LCM)-Abteilung Klinische Pruefung, Praeklinik & Statistik (KPPS)
Italy: Ministry of Health
India: Ministry of Health
China: China Food and Drug Administration (CFDA)
Columbia: Instituto Nacional de Vigilancia de Medicamentos y Alimentes

Keywords provided by Amgen:
High cholesterol
Treatment for high cholesterol
Lowering cholesterol
Lowering high cholesterol
Hypercholesterolemia

Additional relevant MeSH terms:
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Anticholesteremic Agents
Antimetabolites
Enzyme Inhibitors
Hypolipidemic Agents
Lipid Regulating Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Therapeutic Uses

ClinicalTrials.gov processed this record on July 01, 2015