The MURDOCK Study Registry and Biorepository Horizon 1.5 (MURDOCK)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT01708408
Recruitment Status : Recruiting
First Posted : October 17, 2012
Last Update Posted : February 12, 2018
Information provided by (Responsible Party):
Duke University

Brief Summary:
The MURDOCK Study Community Registry and Biorepository (Horizon 1.5) aims to create a large-scale community registry and biorepository that can be used as a vehicle for future health services, epidemiologic, clinical trials and other omics-related research.

Condition or disease Intervention/treatment
Chronic Disease Healthy Volunteers Genetic: Biomarker studies

Detailed Description:
The MURDOCK Study Community Registry and Biorepository's activities include enrolling approximately 50,000 participants who live in Cabarrus County and/or Kannapolis, North Carolina. Participants must consent to (1) use of the data provided by the participant through completion of the Participant Registry Questionnaire for epidemiologic population characterization, (2) annual contact to update their MURDOCK Horizon 1.5 database record, (3) release of their medical information, including but not limited to demographic information, problem lists, medications, social and family history, and results of laboratory and other testing modalities from pre-existing paper or electronic health records or electronic health records that may become available in the future, (4) provision of a blood and urine sample, and (5) contact up to four times/year to request participation in additional research studies.

Study Type : Observational
Estimated Enrollment : 50000 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis The MURDOCK Study Registry and Biorepository Horizon 1.5
Study Start Date : February 2009
Estimated Primary Completion Date : December 2020
Estimated Study Completion Date : December 2020

Group/Cohort Intervention/treatment
community Genetic: Biomarker studies

Primary Outcome Measures :
  1. The MURDOCK Study Registry and Biorepository Horizon 1.5 [ Time Frame: Upto 119 months ]
    To provide information for large-scale epidemiologic and clinical translational research and the research infrastructure to identify specific phenotypes and outcomes to improve medicine

Biospecimen Retention:   Samples With DNA
Blood, 25 mL (whole blood, plasma, serum, buffy coat, PAXgene); Urine, 36 mL

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The Community Registry and Biorepository is designed to create a community registry and biorepository populated by approximately 50,000 residents of Cabarrus County and/or the city of Kannapolis in North Carolina.

Inclusion Criteria:

  1. A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) for 6 or more months of the year
  2. At least 18 years of age
  3. Able to understand and give written informed consent, or have a legal guardian or caregiver present to give informed consent by proxy (assent from a participant between ages 12-18 will be obtained when their parent or legal guardian consents on their behalf).
  4. Willing and able to participate in all 5 components of the registry and biorepository as described above in Section III

Exclusion Criteria:

1. There are no exclusions to participation if all inclusion criteria have been met.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01708408

Contact: Leah Bouk 704-250-5856
Contact: Perla Nunes 704-250-5858

United States, North Carolina
Duke Translational Medicine Institute-MURDOCK Study Recruiting
Kannapolis, North Carolina, United States, 28081
Contact: Leah Bouk    704-250-5861   
Contact: Perla Nunes    704-250-5858   
Principal Investigator: L. Kristin Newby, MD, MHS         
Sponsors and Collaborators
Duke University
Principal Investigator: Kristin M Newby, MD Duke University

Additional Information:
Responsible Party: Duke University Identifier: NCT01708408     History of Changes
Other Study ID Numbers: Pro00011196
First Posted: October 17, 2012    Key Record Dates
Last Update Posted: February 12, 2018
Last Verified: February 2018

Keywords provided by Duke University:
chronic disease
electronic health records

Additional relevant MeSH terms:
Chronic Disease
Disease Attributes
Pathologic Processes