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Study on the Effect of Fish Oil and Appetite

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ClinicalTrials.gov Identifier: NCT01692990
Recruitment Status : Completed
First Posted : September 26, 2012
Last Update Posted : November 12, 2012
Sponsor:
Information provided by (Responsible Party):
AAstrup, University of Copenhagen

Study Description
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Brief Summary:
20 normal-weight healthy subjects (10 males, 10 females) were in two periods given 10 of 0.5-mL capsules/day of fish oil and soybean oil for 3 weeks. In the end of each period they were given a standard breakfast and asked to report their appetite on visual analogue scales (VAS) immediately before and after the meal. The results were analyzed in accordance with the paired design under consideration of both supplement sequence and gender.

Condition or disease Intervention/treatment Phase
Obesity Cachexia Dietary Supplement: Fish oil Early Phase 1

Detailed Description:
In a randomized cross-over design, 20 normal-weight healthy subjects (10 males, 10 females) were given 10 of 0.5-mL capsules/day of fish oil and soybean oil for 3 weeks. In the end of each period they were given a standard breakfast and asked to report their appetite on visual analogue scales (VAS) immediately before and after the meal. The results were analyzed in accordance with the paired design under consideration of both supplement sequence and gender.
Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Study on the Effect of Fish Oil and Appetite
Study Start Date : October 2011
Actual Primary Completion Date : November 2011
Actual Study Completion Date : November 2011

Resource links provided by the National Library of Medicine

Drug Information available for: Fish oil

Arms and Interventions
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Arm Intervention/treatment
Experimental: Fish oil
5 g/d in 10 capsules, providing 3.5 g of long-chain n-3 fatty acids
 Dietary Supplement: Fish oil
For 3 weeks 5 g/d in 10 capsules, providing 3.5 g long-chain n-3 fatty acids in the fish oil period. Cross-over between arms with 1 week of wash out
Placebo Comparator: Soy bean oil
5 g/d in 10 capsules
 Dietary Supplement: Fish oil
For 3 weeks 5 g/d in 10 capsules, providing 3.5 g long-chain n-3 fatty acids in the fish oil period. Cross-over between arms with 1 week of wash out


Outcome Measures
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Primary Outcome Measures :
  1. Appetite and satiation [ Time Frame: October 7th - November 25th 2011 ]
    Appetite and satiation were measured by visual analogue scales (VAS), which assessed satiation, hunger, fullness and desire to eat. Each scale was 100 mm in length with words anchored at each end, expressing the most positive and negative rating of each category.


Secondary Outcome Measures :
  1. Weight change [ Time Frame: October 7th - November 25th 2011 ]
    Body weight was measured on the same scale without shoes and wearing light clothing in the morning before breakfast.


Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Normal weight (18.5<BMI<25 kg/m2).
  • Healthy.

Exclusion Criteria:

  • Subjects taking medication that could influence appetite.
  • Subjects with special nutritional needs e.g. pregnant and lactating, seriously ill or old people.
  • Subjects that had had fish oil-supplements for four weeks prior to the intervention period.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01692990


Locations
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Denmark
Department of Human Nutrition
Frederiksberg, Denmark, 1958
Sponsors and Collaborators
AAstrup
Investigators
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Principal Investigator: Lotte Lauritzen, PhD Department of Human Nutrition
More Information
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Responsible Party: AAstrup, Associate Professore Lotte Lauritzen, University of Copenhagen
ClinicalTrials.gov Identifier: NCT01692990    
Other Study ID Numbers: LL-spec1
First Posted: September 26, 2012    Key Record Dates
Last Update Posted: November 12, 2012
Last Verified: September 2012
Keywords provided by AAstrup, University of Copenhagen:
Appetite
Fish oil
Long-chain n-3 fatty acids
Additional relevant MeSH terms:
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Cachexia
Weight Loss
Body Weight Changes
Body Weight
Thinness