ClinicalTrials.gov
ClinicalTrials.gov Menu

Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01622868
Recruitment Status : Recruiting
First Posted : June 19, 2012
Last Update Posted : May 25, 2018
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)

Brief Summary:
This randomized phase II trial studies how well whole-brain radiation therapy or stereotactic radiosurgery with or without lapatinib ditosylate works in treating patients with breast cancer that has too many of a protein called human epidermal growth factor receptor 2 (HER2) on its cells and has spread to the brain. Radiation therapy uses high energy x rays to kill tumor cells and shrink tumors. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may kill more tumor cells and cause less damage to normal tissue. Lapatinib ditosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether whole-brain radiation therapy or stereotactic radiosurgery together with lapatinib ditosylate is an effective treatment for brain metastasis from breast cancer.

Condition or disease Intervention/treatment Phase
ERBB2 Gene Amplification HER2 Positive Breast Carcinoma Invasive Breast Carcinoma Metastatic Malignant Neoplasm in the Brain Recurrent Breast Carcinoma Stage IV Breast Cancer AJCC v6 and v7 Other: Laboratory Biomarker Analysis Drug: Lapatinib Ditosylate Radiation: Stereotactic Radiosurgery Radiation: Whole-Brain Radiotherapy Phase 2

Detailed Description:

PRIMARY OBJECTIVES:

I. To determine if there is a signal for an increase in complete response (CR) rate in the measurable brain metastases at 12 weeks post radiation therapy (RT) (whole brain or stereotactic radiosurgery [SRS]) as determined by magnetic-resonance imaging (MRI) scan of the brain, with the addition of lapatinib (lapatinib ditosylate) to whole-brain radiation therapy (WBRT)/SRS compared to WBRT/SRS alone.

SECONDARY OBJECTIVES:

I. To evaluate CR rate of the measurable brain metastases at 4 weeks post RT (WBRT/SRS) as determined by MRI scan of the brain, with the addition of lapatinib to WBRT/SRS compared to WBRT/SRS alone.

II. To evaluate objective response rate of measurable brain metastases at 4 and 12 weeks post RT (WBRT/SRS) as determined by MRI scan of the brain, with the addition of lapatinib to WBRT/SRS compared to WBRT/SRS alone.

III. To evaluate targeted lesion-specific objective response rate (CR + partial response [PR]) at 4 and 12 weeks post WBRT/SRS.

IV. To evaluate central nervous system (CNS) progressive disease outside the targeted measurable disease with addition of lapatinib to WBRT/SRS compared to WBRT/SRS alone.

V. To evaluate targeted lesion-specific progression at 4 and 12 weeks post WBRT/SRS.

VI. To evaluate treatment related adverse events when adding lapatinib to WBRT/SRS compared to WBRT/SRS alone.

VII. To evaluate overall CNS complete response: disappearance of all CNS target lesions sustained for at least 4 weeks; with no new lesions, no use of corticosteroids, and patient is stable or improved clinically, when adding lapatinib to WBRT/SRS compared to WBRT/SRS alone.

VIII. To evaluate overall CNS progressive disease (within or outside targeted measurable disease) with addition of lapatinib to WBRT/SRS compared to WBRT/SRS alone.

IX. To evaluate overall survival when adding lapatinib to WBRT/SRS compared to WBRT/SRS alone.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients undergo WBRT 5 days a week for 3 weeks for a total of 15 treatments or SRS for 1 treatment.

ARM B: Patients undergo WBRT or SRS as in Arm A. Patients also receive lapatinib ditosylate orally (PO) once daily (QD) for 6 weeks.

After completion of study treatment, patients are followed up at 4 and 12 weeks and then every 12 weeks thereafter.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 143 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase II Randomized Study of Whole Brain Radiotherapy/Stereotactic Radiosurgery in Combination With Concurrent Lapatinib in Patients With Brain Metastasis From HER2-Positive Breast Cancer: A Collaborative Study of NRG Oncology and KROG
Actual Study Start Date : July 26, 2012
Estimated Primary Completion Date : March 1, 2019

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: Arm A (WBRT or SRS)
Patients undergo WBRT 5 days a week for 3 weeks for a total of 15 treatments, or SRS for 1 treatment.
Other: Laboratory Biomarker Analysis
Correlative studies
Radiation: Stereotactic Radiosurgery
Undergo SRS
Other Names:
  • Stereotactic External Beam Irradiation
  • stereotactic external-beam radiation therapy
  • stereotactic radiation therapy
  • Stereotactic Radiotherapy
  • stereotaxic radiation therapy
  • stereotaxic radiosurgery
Radiation: Whole-Brain Radiotherapy
Undergo WBRT
Other Names:
  • WBRT
  • whole-brain radiation therapy
Experimental: Arm B (lapatinib ditosylate, WBRT or SRS)
Patients undergo WBRT or SRS as in Arm A. Patients also receive lapatinib ditosylate PO QD for 6 weeks.
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Lapatinib Ditosylate
Given PO
Other Name: Tykerb
Radiation: Stereotactic Radiosurgery
Undergo SRS
Other Names:
  • Stereotactic External Beam Irradiation
  • stereotactic external-beam radiation therapy
  • stereotactic radiation therapy
  • Stereotactic Radiotherapy
  • stereotaxic radiation therapy
  • stereotaxic radiosurgery
Radiation: Whole-Brain Radiotherapy
Undergo WBRT
Other Names:
  • WBRT
  • whole-brain radiation therapy



Primary Outcome Measures :
  1. Complete response (CR) rate in the measurable brain metastases measured by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 based on magnetic resonance imaging (MRI) scan of the brain [ Time Frame: 12 weeks ]
    Response in the brain also will be measured using bidimensional measurements (World Health Organization [WHO]/modified McDonald's criteria).


Secondary Outcome Measures :
  1. CR rate of measurable brain metastases measured using revised RECIST version 1.1 based on MRI scan of the brain [ Time Frame: 4 weeks ]
    Response in the brain also will be measured using bidimensional measurements (WHO/modified McDonald's criteria).

  2. Objective response rate (ORR) (CR + partial response [PR]) of measurable brain metastases measured using RECIST version 1.1 based on MRI scan of the brain [ Time Frame: At 4 weeks ]
  3. ORR (CR + PR) of measurable brain metastases measured using RECIST version 1.1 based on MRI scan of the brain [ Time Frame: At 12 weeks ]
  4. Central nervous system (CNS) progressive disease outside the targeted measurable disease [ Time Frame: Up to 4 weeks ]
  5. Targeted lesion-specific progression [ Time Frame: At 4 weeks ]
  6. Targeted lesion-specific progression [ Time Frame: At 12 weeks ]
  7. Incidence of treatment-related toxicity as measured by Common Terminology Criteria for Adverse Events version 4 [ Time Frame: Up to 12 weeks post whole-brain radiation therapy ]
  8. Overall CNS complete response [ Time Frame: Up to 2 years ]
  9. Overall CNS progressive disease [ Time Frame: Up to 4 weeks ]
  10. Overall survival (OS) [ Time Frame: From the date of randomization to the date of first failure, assessed up to 6 years ]
    Estimated by the Kaplan-Meier method. The Cox proportional hazard regression model will be used to analyze the effects of factors, in addition to treatment, that may be associated with OS.



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Pathologically (histologically or cytologically) proven diagnosis of invasive breast cancer
  • HER2-overexpressing breast cancer (3+ staining by immunohistochemistry or HER2 gene amplification by fluorescent in situ hybridization [FISH] or silver in situ hybridization [SISH] >= 2.0)
  • At least 1 measurable unirradiated parenchymal brain metastasis within 21 days prior to study entry; patients who are to undergo SRS must have no more than 10 brain metastases; there is no limit on number of brain metastases for WBRT; the minimum size as measured on T1-weighted gadolinium-enhanced MRI must be as follows according to the number of brain metastases:

    • For a single solitary lesion the size must be >= 10 mm
    • For 2 or more lesions, the size of at least 2 of the lesions must be >= 5 mm
    • Patients may also have the following provided the size requirements above are met:

      • Progressive parenchymal brain metastasis following stereotactic radiosurgery for 1-3 brain metastases, with at least 1 new measurable brain lesion
      • Progressive parenchymal brain metastasis following surgical resection of 1-3 brain metastases, with at least 1 measurable brain lesion
  • History/physical examination within 21 days prior to study entry
  • Karnofsky performance status >= 60 within 21 days prior to study entry
  • Able to swallow and retain oral medication (note: for patients unable to swallow tablets, an oral suspension preparation is acceptable)
  • Absolute neutrophil count (ANC) >= 1,200 cells/mm^3, within 21 days prior to study entry
  • Platelets >= 70,000 cells/mm^3, within 21 days prior to study entry
  • Hemoglobin >= 8.0 g/dL (note: the use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 8.0 g/dL is acceptable), within 21 days prior to study entry
  • Creatinine < 1.5 times institutional upper limit of normal, within 21 days prior to study entry
  • Bilirubin < 1.5 times institutional upper limit of normal, within 21 days prior to study entry
  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 times institutional upper limit of normal with or without liver metastasis, within 21 days prior to study entry
  • Patient must provide study specific informed consent prior to study entry
  • Women of childbearing potential must have a negative serum pregnancy test within 21 days prior to study entry
  • Sexually active women of childbearing potential and sexually active men must practice adequate contraception during therapy and for 12 months after protocol treatment completion
  • Prior lapatinib is allowed as long as the last dose received was > 21 days prior to study entry and provided the patient has not received it at any time after the diagnosis of brain metastasis

Exclusion Criteria:

  • Prior WBRT
  • Prior radiation therapy (RT) (any site) with concurrent lapatinib defined as 1 or more days on which the patient received both radiation therapy and lapatinib on the same day
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Prior invasive malignancy (except non-melanomatous skin cancer, curatively resected thyroid papillary carcinoma, and invasive and non-invasive cancers related to the breast cancer) unless disease free for a minimum of 3 years
  • Leptomeningeal disease
  • Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields except patients who have progressed following stereotactic radiosurgery for 1-3 brain metastases, with at least one new lesion
  • Severe, active co-morbidity, defined as follows:

    • Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
    • Transmural myocardial infarction within the last 6 months
    • Acute bacterial or fungal infection requiring intravenous antibiotics at the time of study entry
    • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of study entry
    • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; hepatic or biliary disease that is acute or currently active or that requires antiviral therapy (with the exception of patients with Gilbert's syndrome, asymptomatic gallstones, liver metastases, or stable chronic liver disease per investigator assessment)
    • History of left ventricular ejection fraction (LVEF) below institutional normal unless repeated and within institutional normal range within 90 days of study entry
  • Grade 2 or greater rash of any cause at time of study entry
  • Grade 2 or greater diarrhea of any cause at time of study entry

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01622868


  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Cancer Center Active, not recruiting
Birmingham, Alabama, United States, 35233
The Kirklin Clinic at Acton Road Active, not recruiting
Birmingham, Alabama, United States, 35243
University of South Alabama Mitchell Cancer Institute Active, not recruiting
Mobile, Alabama, United States, 36688
United States, Arizona
Saint Joseph's Hospital and Medical Center Suspended
Phoenix, Arizona, United States, 85013
The University of Arizona Medical Center-University Campus Active, not recruiting
Tucson, Arizona, United States, 85724
United States, California
Sutter Auburn Faith Hospital Active, not recruiting
Auburn, California, United States, 95602
Sutter Cancer Centers Radiation Oncology Services-Auburn Active, not recruiting
Auburn, California, United States, 95603
Alta Bates Summit Medical Center-Herrick Campus Active, not recruiting
Berkeley, California, United States, 94704
Mills-Peninsula Medical Center Active, not recruiting
Burlingame, California, United States, 94010
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Active, not recruiting
Cameron Park, California, United States, 95682
Mercy San Juan Medical Center Suspended
Carmichael, California, United States, 95608
Sutter Davis Hospital Active, not recruiting
Davis, California, United States, 95616
Memorial Medical Center Active, not recruiting
Modesto, California, United States, 95355
Palo Alto Medical Foundation-Camino Division Active, not recruiting
Mountain View, California, United States, 94040
Palo Alto Medical Foundation-Gynecologic Oncology Active, not recruiting
Mountain View, California, United States, 94040
Sutter Cancer Research Consortium Active, not recruiting
Novato, California, United States, 94945
Palo Alto Medical Foundation Health Care Active, not recruiting
Palo Alto, California, United States, 94301
Stanford Cancer Institute Palo Alto Suspended
Palo Alto, California, United States, 94304
Sutter Cancer Centers Radiation Oncology Services-Roseville Active, not recruiting
Roseville, California, United States, 95661
Sutter Roseville Medical Center Active, not recruiting
Roseville, California, United States, 95661
Sutter Medical Center Sacramento Active, not recruiting
Sacramento, California, United States, 95816
Mercy General Hospital Radiation Oncology Center Suspended
Sacramento, California, United States, 95819
California Pacific Medical Center-Pacific Campus Active, not recruiting
San Francisco, California, United States, 94115
Palo Alto Medical Foundation-Santa Cruz Active, not recruiting
Santa Cruz, California, United States, 95065
Sutter Pacific Medical Foundation Active, not recruiting
Santa Rosa, California, United States, 95403
Palo Alto Medical Foundation-Sunnyvale Active, not recruiting
Sunnyvale, California, United States, 94086
Sutter Cancer Centers Radiation Oncology Services-Vacaville Active, not recruiting
Vacaville, California, United States, 95687
Sutter Solano Medical Center/Cancer Center Active, not recruiting
Vallejo, California, United States, 94589
United States, Connecticut
Smilow Cancer Hospital Care Center at Saint Francis Suspended
Hartford, Connecticut, United States, 06105
The Hospital of Central Connecticut Active, not recruiting
New Britain, Connecticut, United States, 06050
United States, Delaware
Beebe Medical Center Suspended
Lewes, Delaware, United States, 19958
Christiana Gynecologic Oncology LLC Active, not recruiting
Newark, Delaware, United States, 19713
Delaware Clinical and Laboratory Physicians PA Suspended
Newark, Delaware, United States, 19713
Helen F Graham Cancer Center Suspended
Newark, Delaware, United States, 19713
Medical Oncology Hematology Consultants PA Suspended
Newark, Delaware, United States, 19713
Regional Hematology and Oncology PA Suspended
Newark, Delaware, United States, 19713
Christiana Care Health System-Christiana Hospital Suspended
Newark, Delaware, United States, 19718
Beebe Health Campus Suspended
Rehoboth Beach, Delaware, United States, 19971
Nanticoke Memorial Hospital Suspended
Seaford, Delaware, United States, 19973
Christiana Care Health System-Wilmington Hospital Suspended
Wilmington, Delaware, United States, 19801
United States, Florida
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Suspended
Deerfield Beach, Florida, United States, 33442
University of Miami Miller School of Medicine-Sylvester Cancer Center Suspended
Miami, Florida, United States, 33136
United States, Georgia
Piedmont Hospital Suspended
Atlanta, Georgia, United States, 30309
Northside Hospital Active, not recruiting
Atlanta, Georgia, United States, 30342
Northside Hospital-Forsyth Suspended
Cumming, Georgia, United States, 30041
Piedmont Fayette Hospital Suspended
Fayetteville, Georgia, United States, 30214
Northeast Georgia Medical Center-Gainesville Suspended
Gainesville, Georgia, United States, 30501
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Recruiting
Savannah, Georgia, United States, 31405
Contact: Joshua T. Mckenzie    912-819-5704      
Principal Investigator: Joshua T. Mckenzie         
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Suspended
Boise, Idaho, United States, 83706
Saint Alphonsus Cancer Care Center-Caldwell Suspended
Caldwell, Idaho, United States, 83605
Idaho Urologic Institute-Meridian Suspended
Meridian, Idaho, United States, 83642
United States, Illinois
Rush - Copley Medical Center Suspended
Aurora, Illinois, United States, 60504
John H Stroger Jr Hospital of Cook County Suspended
Chicago, Illinois, United States, 60612
Presence Saint Joseph Hospital-Chicago Suspended
Chicago, Illinois, United States, 60657
Carle on Vermilion Suspended
Danville, Illinois, United States, 61832
Carle Physician Group-Effingham Suspended
Effingham, Illinois, United States, 62401
Carle Physician Group-Mattoon/Charleston Suspended
Mattoon, Illinois, United States, 61938
Good Samaritan Regional Health Center Suspended
Mount Vernon, Illinois, United States, 62864
Carle Cancer Center Suspended
Urbana, Illinois, United States, 61801
United States, Indiana
Elkhart Clinic Active, not recruiting
Elkhart, Indiana, United States, 46514-2098
Michiana Hematology Oncology PC-Elkhart Active, not recruiting
Elkhart, Indiana, United States, 46514
Elkhart General Hospital Active, not recruiting
Elkhart, Indiana, United States, 46515
Radiation Oncology Associates PC Suspended
Fort Wayne, Indiana, United States, 46804
Parkview Hospital Randallia Suspended
Fort Wayne, Indiana, United States, 46805
Community Howard Regional Health Active, not recruiting
Kokomo, Indiana, United States, 46904
IU Health La Porte Hospital Active, not recruiting
La Porte, Indiana, United States, 46350
Memorial Regional Cancer Center Day Road Recruiting
Mishawaka, Indiana, United States, 46545
Contact: David A. Hornback    800-284-7370      
Principal Investigator: David A. Hornback         
Michiana Hematology Oncology PC-Mishawaka Active, not recruiting
Mishawaka, Indiana, United States, 46545
Saint Joseph Regional Medical Center-Mishawaka Active, not recruiting
Mishawaka, Indiana, United States, 46545
Michiana Hematology Oncology PC-Plymouth Active, not recruiting
Plymouth, Indiana, United States, 46563
Reid Health Active, not recruiting
Richmond, Indiana, United States, 47374
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: David A. Hornback    800-284-7370      
Principal Investigator: David A. Hornback         
Michiana Hematology Oncology PC-South Bend Suspended
South Bend, Indiana, United States, 46601
South Bend Clinic Active, not recruiting
South Bend, Indiana, United States, 46617
Northern Indiana Cancer Research Consortium Recruiting
South Bend, Indiana, United States, 46628
Contact: Binh N. Tran    574-237-1328      
Principal Investigator: Binh N. Tran         
Michiana Hematology Oncology PC-Westville Active, not recruiting
Westville, Indiana, United States, 46391
United States, Iowa
Saint Luke's Hospital Recruiting
Cedar Rapids, Iowa, United States, 52402
Contact: Nagendra (Bobby) S. Koneru    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Nagendra (Bobby) S. Koneru         
United States, Kansas
Central Care Cancer Center - Garden City Suspended
Garden City, Kansas, United States, 67846
Central Care Cancer Center - Great Bend Suspended
Great Bend, Kansas, United States, 67530
Kansas Institute of Medicine Cancer and Blood Center Suspended
Lenexa, Kansas, United States, 66219
Minimally Invasive Surgery Hospital Suspended
Lenexa, Kansas, United States, 66219
Menorah Medical Center Suspended
Overland Park, Kansas, United States, 66209
Saint Luke's South Hospital Suspended
Overland Park, Kansas, United States, 66213
Kansas City NCI Community Oncology Research Program Suspended
Prairie Village, Kansas, United States, 66208
United States, Kentucky
Norton Hospital Pavilion and Medical Campus Active, not recruiting
Louisville, Kentucky, United States, 40202
Norton Suburban Hospital and Medical Campus Active, not recruiting
Louisville, Kentucky, United States, 40207
United States, Louisiana
Ochsner Medical Center Jefferson Active, not recruiting
New Orleans, Louisiana, United States, 70121
United States, Maryland
Greater Baltimore Medical Center Suspended
Baltimore, Maryland, United States, 21204
United States, Massachusetts
Boston Medical Center Suspended
Boston, Massachusetts, United States, 02118
United States, Michigan
Bixby Medical Center Suspended
Adrian, Michigan, United States, 49221
Hickman Cancer Center Suspended
Adrian, Michigan, United States, 49221
Michigan Cancer Research Consortium NCORP Terminated
Ann Arbor, Michigan, United States, 48106
Saint Joseph Mercy Hospital Suspended
Ann Arbor, Michigan, United States, 48106
University of Michigan Comprehensive Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: James A. Hayman    800-865-1125      
Principal Investigator: James A. Hayman         
Bronson Battle Creek Recruiting
Battle Creek, Michigan, United States, 49017
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Spectrum Health Big Rapids Hospital Suspended
Big Rapids, Michigan, United States, 49307
Henry Ford Cancer Institute¿Downriver Recruiting
Brownstown, Michigan, United States, 48183
Contact: Eleanor M. Walker    313-916-1784      
Principal Investigator: Eleanor M. Walker         
Henry Ford Macomb Hospital-Clinton Township Suspended
Clinton Township, Michigan, United States, 48038
Beaumont Hospital-Dearborn Suspended
Dearborn, Michigan, United States, 48124
Henry Ford Hospital Recruiting
Detroit, Michigan, United States, 48202
Contact: Eleanor M. Walker    313-916-1784      
Principal Investigator: Eleanor M. Walker         
Saint John Hospital and Medical Center Suspended
Detroit, Michigan, United States, 48236
Green Bay Oncology - Escanaba Suspended
Escanaba, Michigan, United States, 49829
Genesys Hurley Cancer Institute Suspended
Flint, Michigan, United States, 48503
Hurley Medical Center Suspended
Flint, Michigan, United States, 48503
Cancer Research Consortium of West Michigan NCORP Terminated
Grand Rapids, Michigan, United States, 49503
Mercy Health Saint Mary's Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Green Bay Oncology - Iron Mountain Suspended
Iron Mountain, Michigan, United States, 49801
Allegiance Health Suspended
Jackson, Michigan, United States, 49201
Borgess Medical Center Suspended
Kalamazoo, Michigan, United States, 49001
Bronson Methodist Hospital Suspended
Kalamazoo, Michigan, United States, 49007
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Sparrow Hospital Suspended
Lansing, Michigan, United States, 48912
Saint Mary Mercy Hospital Suspended
Livonia, Michigan, United States, 48154
Mercy Memorial Hospital Suspended
Monroe, Michigan, United States, 48162
Toledo Clinic Cancer Centers-Monroe Suspended
Monroe, Michigan, United States, 48162
Mercy Health Mercy Campus Recruiting
Muskegon, Michigan, United States, 49444
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Lakeland Hospital Niles Recruiting
Niles, Michigan, United States, 49120
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
21st Century Oncology-Pontiac Suspended
Pontiac, Michigan, United States, 48341
Saint Joseph Mercy Oakland Suspended
Pontiac, Michigan, United States, 48341
Lake Huron Medical Center Suspended
Port Huron, Michigan, United States, 48060
Saint Mary's of Michigan Suspended
Saginaw, Michigan, United States, 48601
Lakeland Medical Center Saint Joseph Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Marie Yeager Cancer Center Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Saint John Macomb-Oakland Hospital Suspended
Warren, Michigan, United States, 48093
Henry Ford West Bloomfield Hospital Recruiting
West Bloomfield, Michigan, United States, 48322
Contact: Eleanor M. Walker    313-916-1784      
Principal Investigator: Eleanor M. Walker         
Metro Health Hospital Recruiting
Wyoming, Michigan, United States, 49519
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
United States, Minnesota
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Saint John's Hospital - Healtheast Suspended
Maplewood, Minnesota, United States, 55109
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Health Partners Inc Suspended
Minneapolis, Minnesota, United States, 55454
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Metro Minnesota Community Oncology Research Consortium Suspended
Saint Louis Park, Minnesota, United States, 55416
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Paul W. Sperduto    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Patrick J. Flynn    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Patrick J. Flynn         
United States, Mississippi
University of Mississippi Medical Center Active, not recruiting
Jackson, Mississippi, United States, 39216
Singing River Hospital Recruiting
Pascagoula, Mississippi, United States, 39581
Contact: James E. Clarkson    228-809-5292      
Principal Investigator: James E. Clarkson         
United States, Missouri
Central Care Cancer Center - Bolivar Suspended
Bolivar, Missouri, United States, 65613
Cape Radiation Oncology Suspended
Cape Girardeau, Missouri, United States, 63703
Saint Francis Medical Center Suspended
Cape Girardeau, Missouri, United States, 63703
Siteman Cancer Center at West County Hospital Suspended
Creve Coeur, Missouri, United States, 63141
Centerpoint Medical Center LLC Suspended
Independence, Missouri, United States, 64057
Mercy Hospital Joplin Suspended
Joplin, Missouri, United States, 64804
Saint Luke's Hospital of Kansas City Suspended
Kansas City, Missouri, United States, 64111
North Kansas City Hospital Suspended
Kansas City, Missouri, United States, 64116
Heartland Hematology and Oncology Associates Incorporated Suspended
Kansas City, Missouri, United States, 64118
Research Medical Center Suspended
Kansas City, Missouri, United States, 64132
Saint Luke's East - Lee's Summit Suspended
Lee's Summit, Missouri, United States, 64086
Liberty Radiation Oncology Center Suspended
Liberty, Missouri, United States, 64068
Delbert Day Cancer Institute at PCRMC Recruiting
Rolla, Missouri, United States, 65401
Contact: Jay W. Carlson    888-221-4849      
Principal Investigator: Jay W. Carlson         
Mercy Clinic-Rolla-Cancer and Hematology Recruiting
Rolla, Missouri, United States, 65401
Contact: Jay W. Carlson    888-221-4849      
Principal Investigator: Jay W. Carlson         
Heartland Regional Medical Center Recruiting
Saint Joseph, Missouri, United States, 64507
Contact: Jay W. Carlson    888-221-4849      
Principal Investigator: Jay W. Carlson         
Saint Joseph Oncology Inc Suspended
Saint Joseph, Missouri, United States, 64507
Saint Louis Cancer and Breast Institute-South City Suspended
Saint Louis, Missouri, United States, 63109
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Imran Zoberi    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Imran Zoberi         
Siteman Cancer Center-South County Suspended
Saint Louis, Missouri, United States, 63129
Mercy Hospital Saint Louis Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Jay W. Carlson    888-221-4849      
Principal Investigator: Jay W. Carlson         
Saint Louis-Cape Girardeau CCOP Active, not recruiting
Saint Louis, Missouri, United States, 63141
Siteman Cancer Center at Saint Peters Hospital Suspended
Saint Peters, Missouri, United States, 63376
Cancer Research for the Ozarks NCORP Terminated
Springfield, Missouri, United States, 65804
Mercy Hospital Springfield Recruiting
Springfield, Missouri, United States, 65804
Contact: Jay W. Carlson    888-221-4849      
Principal Investigator: Jay W. Carlson         
CoxHealth South Hospital Recruiting
Springfield, Missouri, United States, 65807
Contact: Jay W. Carlson    888-221-4849      
Principal Investigator: Jay W. Carlson         
United States, Nevada
Renown Regional Medical Center Suspended
Reno, Nevada, United States, 89502
United States, New Hampshire
Elliot Hospital Suspended
Manchester, New Hampshire, United States, 03103
United States, New Jersey
Saint Barnabas Medical Center Active, not recruiting
Livingston, New Jersey, United States, 07039
Virtua Memorial Active, not recruiting
Mount Holly, New Jersey, United States, 08060
Virtua Voorhees Active, not recruiting
Voorhees, New Jersey, United States, 08043
United States, New Mexico
University of New Mexico Cancer Center Recruiting
Albuquerque, New Mexico, United States, 87102
Contact: Benny J. Liem    505-925-0366    LByatt@nmcca.org   
Principal Investigator: Benny J. Liem         
Memorial Medical Center - Las Cruces Recruiting
Las Cruces, New Mexico, United States, 88011
Contact: Benny J. Liem    505-925-0366    LByatt@nmcca.org   
Principal Investigator: Benny J. Liem         
United States, New York
Montefiore Medical Center - Moses Campus Suspended
Bronx, New York, United States, 10467
New York-Presbyterian/Brooklyn Methodist Hospital Recruiting
Brooklyn, New York, United States, 11215
Contact: Sameer Rafla-Demetrious    718-780-3677    Adg9003@nyp.org   
Principal Investigator: Sameer Rafla-Demetrious         
Roswell Park Cancer Institute Suspended
Buffalo, New York, United States, 14263
Hematology Oncology Associates of Central New York-East Syracuse Active, not recruiting
East Syracuse, New York, United States, 13057
Mount Sinai Hospital Active, not recruiting
New York, New York, United States, 10029
Highland Hospital Suspended
Rochester, New York, United States, 14620
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
United States, North Carolina
Park Ridge Health Suspended
Hendersonville, North Carolina, United States, 28792
Iredell Memorial Hospital Suspended
Statesville, North Carolina, United States, 28677
Southeast Clinical Oncology Research (SCOR) Consortium NCORP Terminated
Winston-Salem, North Carolina, United States, 27104
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center Active, not recruiting
Akron, Ohio, United States, 44304
Cleveland Clinic Akron General Active, not recruiting
Akron, Ohio, United States, 44307
Radiation Oncology Center Active, not recruiting
Alliance, Ohio, United States, 44601
Summa Barberton Hospital Active, not recruiting
Barberton, Ohio, United States, 44203
Cleveland Clinic Cancer Center Beachwood Suspended
Beachwood, Ohio, United States, 44122
UHHS-Chagrin Highlands Medical Center Suspended
Beachwood, Ohio, United States, 44122
Toledo Clinic Cancer Centers-Bowling Green Suspended
Bowling Green, Ohio, United States, 43402
Mercy Medical Center Suspended
Canton, Ohio, United States, 44708
Dayton Physicians LLC-Miami Valley South Active, not recruiting
Centerville, Ohio, United States, 45459
Miami Valley Hospital South Active, not recruiting
Centerville, Ohio, United States, 45459
Geauga Hospital Suspended
Chardon, Ohio, United States, 44024
Oncology Hematology Care Inc-Kenwood Active, not recruiting
Cincinnati, Ohio, United States, 45236
Case Western Reserve University Suspended
Cleveland, Ohio, United States, 44106
Cleveland Clinic Cancer Center/Fairview Hospital Suspended
Cleveland, Ohio, United States, 44111
Cleveland Clinic Foundation Suspended
Cleveland, Ohio, United States, 44195
Ohio State University Comprehensive Cancer Center Suspended
Columbus, Ohio, United States, 43210
Good Samaritan Hospital - Dayton Active, not recruiting
Dayton, Ohio, United States, 45406
Miami Valley Hospital Active, not recruiting
Dayton, Ohio, United States, 45409
Dayton Physicians LLC-Samaritan North Active, not recruiting
Dayton, Ohio, United States, 45415
Samaritan North Health Center Active, not recruiting
Dayton, Ohio, United States, 45415
Mercy Cancer Center-Elyria Suspended
Elyria, Ohio, United States, 44035
Armes Family Cancer Center Active, not recruiting
Findlay, Ohio, United States, 45840
Blanchard Valley Hospital Active, not recruiting
Findlay, Ohio, United States, 45840
Orion Cancer Care Active, not recruiting
Findlay, Ohio, United States, 45840
Atrium Medical Center-Middletown Regional Hospital Active, not recruiting
Franklin, Ohio, United States, 45005-1066
Dayton Physicians LLC-Atrium Active, not recruiting
Franklin, Ohio, United States, 45005
Dayton Physicians LLC-Wayne Active, not recruiting
Greenville, Ohio, United States, 45331
Wayne Hospital Active, not recruiting
Greenville, Ohio, United States, 45331
Cleveland Clinic Cancer Center Independence Suspended
Independence, Ohio, United States, 44131
Kettering Medical Center Active, not recruiting
Kettering, Ohio, United States, 45429
Lima Memorial Hospital Suspended
Lima, Ohio, United States, 45804
Cleveland Clinic Cancer Center Mansfield Suspended
Mansfield, Ohio, United States, 44906
Toledo Clinic Cancer Centers-Maumee Suspended
Maumee, Ohio, United States, 43537
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Suspended
Maumee, Ohio, United States, 43537
Hillcrest Hospital Cancer Center Suspended
Mayfield Heights, Ohio, United States, 44124
Summa Health Center at Lake Medina Active, not recruiting
Medina, Ohio, United States, 44256
Lake University Ireland Cancer Center Suspended
Mentor, Ohio, United States, 44060
Southwest General Health Center Ireland Cancer Center Suspended
Middleburg Heights, Ohio, United States, 44130
Saint Charles Hospital Suspended
Oregon, Ohio, United States, 43616
Toledo Clinic Cancer Centers-Oregon Suspended
Oregon, Ohio, United States, 43616
University Hospitals Parma Medical Center Suspended
Parma, Ohio, United States, 44129
Robinson Radiation Oncology Active, not recruiting
Ravenna, Ohio, United States, 44266
University Hospitals Portage Medical Center Suspended
Ravenna, Ohio, United States, 44266
UH Seidman Cancer Center at Salem Regional Medical Center Suspended
Salem, Ohio, United States, 44460
North Coast Cancer Care Suspended
Sandusky, Ohio, United States, 44870
Springfield Regional Cancer Center Active, not recruiting
Springfield, Ohio, United States, 45504
Springfield Regional Medical Center Active, not recruiting
Springfield, Ohio, United States, 45505
Cleveland Clinic Cancer Center Strongsville Suspended
Strongsville, Ohio, United States, 44136
Flower Hospital Suspended
Sylvania, Ohio, United States, 43560
Mercy Hospital of Tiffin Suspended
Tiffin, Ohio, United States, 44883
Saint Vincent Mercy Medical Center Suspended
Toledo, Ohio, United States, 43608
University of Toledo Suspended
Toledo, Ohio, United States, 43614
Toledo Community Hospital Oncology Program CCOP Suspended
Toledo, Ohio, United States, 43617
Mercy Saint Anne Hospital Suspended
Toledo, Ohio, United States, 43623
Toledo Clinic Cancer Centers-Toledo Suspended
Toledo, Ohio, United States, 43623
Dayton Physicians LLC-Upper Valley Active, not recruiting
Troy, Ohio, United States, 45373
Upper Valley Medical Center Active, not recruiting
Troy, Ohio, United States, 45373
Fulton County Health Center Suspended
Wauseon, Ohio, United States, 43567
UHHS-Westlake Medical Center Suspended
Westlake, Ohio, United States, 44145
Cancer Treatment Center Terminated
Wooster, Ohio, United States, 44691
Cleveland Clinic Wooster Family Health and Surgery Center Suspended
Wooster, Ohio, United States, 44691
United States, Oklahoma
Natalie Warren Bryant Cancer Center at Saint Francis Suspended
Tulsa, Oklahoma, United States, 74136
Warren Clinic Oncology-Tulsa Suspended
Tulsa, Oklahoma, United States, 74146
United States, Oregon
Legacy Mount Hood Medical Center Suspended
Gresham, Oregon, United States, 97030
Legacy Good Samaritan Hospital and Medical Center Suspended
Portland, Oregon, United States, 97210
United States, Pennsylvania
Abington Memorial Hospital Active, not recruiting
Abington, Pennsylvania, United States, 19001
Lehigh Valley Hospital-Cedar Crest Suspended
Allentown, Pennsylvania, United States, 18103
Lehigh Valley Hospital - Muhlenberg Suspended
Bethlehem, Pennsylvania, United States, 18017
Pocono Medical Center Suspended
East Stroudsburg, Pennsylvania, United States, 18301
Thomas Jefferson University Hospital Suspended
Philadelphia, Pennsylvania, United States, 19107
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Michael L. Haas    610-988-9323      
Principal Investigator: Michael L. Haas         
United States, South Carolina
AnMed Health Cancer Center Suspended
Anderson, South Carolina, United States, 29621
Medical University of South Carolina Active, not recruiting
Charleston, South Carolina, United States, 29425
Gibbs Cancer Center-Gaffney Suspended
Gaffney, South Carolina, United States, 29341
Gibbs Cancer Center-Pelham Suspended
Greer, South Carolina, United States, 29651
Spartanburg Medical Center Suspended
Spartanburg, South Carolina, United States, 29303
United States, Texas
Covenant Medical Center-Lakeside Suspended
Lubbock, Texas, United States, 79410
University of Texas Health Science Center at San Antonio Active, not recruiting
San Antonio, Texas, United States, 78229
United States, Vermont
Central Vermont Medical Center/National Life Cancer Treatment Suspended
Berlin, Vermont, United States, 05602
University of Vermont Medical Center Suspended
Burlington, Vermont, United States, 05401
University of Vermont College of Medicine Suspended
Burlington, Vermont, United States, 05405
United States, Virginia
Fredericksburg Oncology Inc Suspended
Fredericksburg, Virginia, United States, 22401
Virginia Commonwealth University/Massey Cancer Center Recruiting
Richmond, Virginia, United States, 23298
Contact: Timothy J. Harris       mwellons@vcu.edu   
Principal Investigator: Timothy J. Harris         
United States, Washington
Legacy Salmon Creek Hospital Suspended
Vancouver, Washington, United States, 98686
United States, West Virginia
Wheeling Hospital/Schiffler Cancer Center Active, not recruiting
Wheeling, West Virginia, United States, 26003
United States, Wisconsin
Green Bay Oncology at Saint Vincent Hospital Suspended
Green Bay, Wisconsin, United States, 54301-3526
Saint Vincent Hospital Cancer Center Green Bay Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Eva N. Christensen    920-433-8889    Christy.Gilchrist@hshs.org   
Principal Investigator: Eva N. Christensen         
Green Bay Oncology Limited at Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Eva N. Christensen    920-433-8889      
Principal Investigator: Eva N. Christensen         
Saint Vincent Hospital Cancer Center at Saint Mary's Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Eva N. Christensen    920-433-8889    Christy.Gilchrist@hshs.org   
Principal Investigator: Eva N. Christensen         
UW Cancer Center Johnson Creek Recruiting
Johnson Creek, Wisconsin, United States, 53038
Contact: Bethany M. Anderson    920-699-3500    lynda.persico@uwmf.wisc.edu   
Principal Investigator: Bethany M. Anderson         
University of Wisconsin Hospital and Clinics Recruiting
Madison, Wisconsin, United States, 53792
Contact: Bethany M. Anderson    800-622-8922      
Principal Investigator: Bethany M. Anderson         
Holy Family Memorial Hospital Recruiting
Manitowoc, Wisconsin, United States, 54221
Contact: Eva N. Christensen    920-433-8889    Christy.Gilchrist@hshs.org   
Principal Investigator: Eva N. Christensen         
Bay Area Medical Center Active, not recruiting
Marinette, Wisconsin, United States, 54143
Columbia Saint Mary's Hospital - Ozaukee Recruiting
Mequon, Wisconsin, United States, 53097
Contact: Craig A. Schulz    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Craig A. Schulz         
Columbia Saint Mary's Water Tower Medical Commons Recruiting
Milwaukee, Wisconsin, United States, 53211
Contact: Craig A. Schulz    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Craig A. Schulz         
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Adam D. Currey    888-469-6614      
Principal Investigator: Adam D. Currey         
Cancer Center of Western Wisconsin Suspended
New Richmond, Wisconsin, United States, 54017
Green Bay Oncology - Oconto Falls Suspended
Oconto Falls, Wisconsin, United States, 54154
Saint Vincent Hospital Cancer Center at Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235-1495
Contact: Eva N. Christensen    920-433-8889    Christy.Gilchrist@hshs.org   
Principal Investigator: Eva N. Christensen         
Green Bay Oncology - Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235
Contact: Eva N. Christensen    920-433-8889      
Principal Investigator: Eva N. Christensen         
Canada, Ontario
Juravinski Cancer Centre at Hamilton Health Sciences Active, not recruiting
Hamilton, Ontario, Canada, L8V 5C2
Canada, Quebec
Jewish General Hospital Suspended
Montreal, Quebec, Canada, H3T 1E2
Korea, Republic of
Keimyung University-Dongsan Medical Center Recruiting
Jung-Ku, Daegu, Korea, Republic of, 700-712
Contact: Jin-Hee Kim       ho@dsmc.or.kr   
Principal Investigator: Jin-Hee Kim         
National Cancer Center-Korea Recruiting
Goyang-si, Gyeonggi-do, Korea, Republic of, 410-769
Contact: Kwan H. Cho    82-31-920-1934      
Principal Investigator: Kwan H. Cho         
Chonnam National University Hwasun Hospital Suspended
Hwasun-gun, Jeollanam-do, Korea, Republic of, 519-763
Samsung Medical Center Suspended
Seoul, Korea, Korea, Republic of, 135-710
Seoul National University Bundang Hospital Suspended
Seongnam City, Kyeonggi-do, Korea, Republic of, 463-707
Seoul National University Hospital Suspended
Seoul, Korea, Republic of, 110-744
Yonsei University Health System-Severance Hospital Suspended
Seoul, Korea, Republic of, 120-752
Gangnam Severance Hospital Suspended
Seoul, Korea, Republic of, 135-720
Sponsors and Collaborators
National Cancer Institute (NCI)
Investigators
Principal Investigator: In Kim NRG Oncology

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT01622868     History of Changes
Other Study ID Numbers: NCI-2012-01977
NCI-2012-01977 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
RTOG-1119
CDR0000735353
RTOG-1119 ( Other Identifier: NRG Oncology )
RTOG-1119 ( Other Identifier: CTEP )
U10CA180868 ( U.S. NIH Grant/Contract )
U10CA021661 ( U.S. NIH Grant/Contract )
First Posted: June 19, 2012    Key Record Dates
Last Update Posted: May 25, 2018
Last Verified: March 2018

Additional relevant MeSH terms:
Carcinoma
Breast Neoplasms
Neoplasms
Neoplasms, Second Primary
Brain Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms by Site
Breast Diseases
Skin Diseases
Central Nervous System Neoplasms
Nervous System Neoplasms
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Lapatinib
Antineoplastic Agents
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action