A Safety and Tolerability Study of Assisted and Self-Administered Subcutaneous (SC) Herceptin (Trastuzumab) as Adjuvant Therapy in Early Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer (SafeHER)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01566721
Recruitment Status : Active, not recruiting
First Posted : March 29, 2012
Results First Posted : April 18, 2017
Last Update Posted : December 7, 2018
Information provided by (Responsible Party):
Hoffmann-La Roche

Brief Summary:
This multicenter, two-cohort, non-randomized, open-label study will evaluate the safety and tolerability of assisted and self-administered SC Herceptin as adjuvant therapy in participants with early HER2-positive breast cancer following tumor excision. Participants will receive Herceptin 600 milligrams (mg) SC every 3 weeks for 18 cycles, either by an assisted administration using a conventional syringe and needle/vial formulation (Cohort A) or with assisted and self-administration using a single-use injection device (SID) in selected participants (Cohort B).

Condition or disease Intervention/treatment Phase
Breast Neoplasms Drug: Herceptin Phase 3

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 2577 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase III Prospective, Two-Cohort Non-Randomized, Multi-Centre, Multinational, Open-Label Study to Assess the Safety of Assisted- and Self-Administered Subcutaneous Trastuzumab as Therapy in Patients With Operable HER2-Positive Early Breast Cancer
Actual Study Start Date : May 17, 2012
Actual Primary Completion Date : March 10, 2015
Estimated Study Completion Date : March 3, 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Breast Cancer
Drug Information available for: Trastuzumab

Arm Intervention/treatment
Experimental: Cohort A: SC Herceptin by Needle/Syringe
Participants will receive SC Herceptin by an assisted administration using a conventional syringe and needle/vial formulation.
Drug: Herceptin
Herceptin will be given as 600 mg SC (into thigh) on Day 1 of each 3-week cycle for up to 18 cycles.
Other Name: Trastuzumab

Experimental: Cohort B: SC Herceptin by SID
Participants will receive SC Herceptin with assisted and/or self-administered use of an SID. The first administration will be performed by a trained healthcare professional. If well tolerated and the participant is willing and judged competent to perform self-administration, subsequent administration of SC Herceptin may be performed by the participant.
Drug: Herceptin
Herceptin will be given as 600 mg SC (into thigh) on Day 1 of each 3-week cycle for up to 18 cycles.
Other Name: Trastuzumab

Primary Outcome Measures :
  1. Percentage of Participants With At Least 1 Adverse Event (AE) During the Treatment Period [ Time Frame: From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year) ]
    Participants were planned to receive a total of 18 cycles of SC Herceptin. An AE was defined as any untoward medical occurrence in a participant administered SC Herceptin. Examples included unfavorable/unintended signs and symptoms, new or exacerbated disease, recurrence of intermittent condition, deterioration in laboratory value or other clinical test, or adverse procedure-related events. The percentage of participants with at least 1 AE during the treatment period (regardless of severity or seriousness) was reported.

  2. Percentage of Participants With a Grade 3 or Higher AE During the Treatment Period [ Time Frame: From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year) ]
    Participants were planned to receive a total of 18 cycles of SC Herceptin. An AE was defined as any untoward medical occurrence in a participant administered SC Herceptin. Examples included unfavorable/unintended signs and symptoms, new or exacerbated disease, recurrence of intermittent condition, deterioration in laboratory value or other clinical test, or adverse procedure-related events. AEs were graded according to National Cancer Institute Common Terminology Criteria Version 4.0. Grade 3 AEs were those considered severe or medically significant but not immediately life-threatening. Grade 4 AEs were those considered life-threatening and/or for which urgent intervention was indicated. Grade 5 AEs were those resulting in death. The percentage of participants with a Grade 3 or higher (i.e., Grade 3 to 5) AE during the treatment period was reported.

  3. Percentage of Participants With Treatment Interruption Due to an AE [ Time Frame: From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year) ]
    Participants were planned to receive a total of 18 cycles of SC Herceptin. An AE was defined as any untoward medical occurrence in a participant administered SC Herceptin. Examples included unfavorable/unintended signs and symptoms, new or exacerbated disease, recurrence of intermittent condition, deterioration in laboratory value or other clinical test, or adverse procedure-related events. The percentage of participants with SC Herceptin treatment interrupted to assess or treat AEs was reported.

  4. Number of Herceptin Cycles Received [ Time Frame: From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year) ]
    Participants were planned to receive a total of 18 cycles of SC Herceptin. The median number of cycles actually received was reported.

  5. Percentage of Participants by Total Number of Herceptin Cycles Received [ Time Frame: From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year) ]
    Participants were planned to receive a total of 18 cycles of SC Herceptin. The percentage of participants was reported by the total number of cycles actually received. Because the data are presented non-cumulatively, this table reflects participant distribution by the highest number of cycles received.

  6. Percentage of Participants Who Received Concomitant Cancer Therapy [ Time Frame: From Baseline to data cutoff of 10 March 2015 (up to approximately 3 years) ]
    Concomitant cancer treatment included chemotherapy, radiotherapy, and hormone therapy administered during the study. The percentage of participants who received any of these concomitant therapies was reported.

  7. Percentage of Participants Who Received Concomitant Non-Cancer Therapy [ Time Frame: From Baseline to data cutoff of 10 March 2015 (up to approximately 3 years) ]
    Concomitant non-cancer treatment included any pharmacologic interventions administered during the study other than chemotherapy, radiotherapy, or hormone therapy. The percentage of participants who received any concomitant non-cancer therapies was reported.

Secondary Outcome Measures :
  1. Disease-Free Survival (DFS) [ Time Frame: From Baseline to time of event (up to approximately 8 years) ]
    DFS is defined as the time from first dose of SC Herceptin to the first event of local, regional or distant recurrence, contralateral invasive breast cancer (including ipsilateral ductal carcinoma in situ) or death due to any cause.

  2. Percentage of Participants Who Died by Data Cutoff of 10 March 2015 [ Time Frame: From Baseline to time of event (maximum follow-up approximately 3 years as of data cutoff of 10 March 2015) ]
    The percentage of participants who died from any cause was reported.

  3. Overall Survival (OS) [ Time Frame: From Baseline to time of event (up to approximately 8 years) ]
  4. Percentage of Participants by Item Response to SID Satisfaction Questionnaire [ Time Frame: Cycle 4 (cycle length 3 weeks) and last safety follow-up (LSFU) (approximately 1 year) ]
    The SID satisfaction questionnaire was administered twice during the study and asked participants to respond to five statements using a Likert scale from "Strongly Disagree" to "Strongly Agree". Questionnaire items were as follows: "I felt comfortable injecting the study drug by myself" (Comfortable), "The SID was convenient and easy to use" (Easy to Use), "I am confident giving myself an injection in the thigh with the SID" (Confident), "Taking all things into account I find self-administration using the SID satisfactory" (Satisfactory), "If given the opportunity I would choose to continue self-injecting the study drug using the SID in the future" (Continue). Participants could only select one response per questionnaire item. There was no calculation of any score, but rather, descriptive summaries were generated by item response. The percentage of participants was reported by the response given for each item on the SID satisfaction questionnaire.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Histologically confirmed early invasive HER2-positive carcinoma of the breast with no evidence of residual, locally recurrent, or metastatic disease and defined as clinical Stage I to IIIC that is eligible for treatment with Herceptin
  • Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
  • Screening left ventricular ejection fraction (LVEF) greater than or equal to (≥) 55%

Exclusion Criteria:

  • Previous neoadjuvant or adjuvant breast cancer treatment with an approved or investigational anti-HER2 agent
  • History of other malignancy except for curatively treated carcinoma in situ of the cervix, basal cell carcinoma, or curatively treated malignancies (other than breast cancer) where the participant has been disease-free for at least 5 years
  • Past history of ductal carcinoma in situ treated with any systemic therapy or with radiation therapy to the ipsilateral breast where invasive cancer subsequently developed
  • Metastatic disease
  • Inadequate bone marrow, hepatic, or renal function
  • Serious cardiac or cardiovascular disease including uncontrolled hypertension or history of hypertensive crisis or hypertensive encephalopathy
  • History of severe allergic or immunological reactions, such as difficult-to-control asthma
  • Pregnant or lactating women

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01566721

  Hide Study Locations
University "Mother Theresa" Hospital Center; Oncology Department
Tirana, Albania, 1000
CPMC; Service d'Oncologie Médicale
Algiers, Algeria, 16000
Fundación CENIT para la Investigación en Neurociencias
Buenos Aires, Argentina, C1125ABD
Hospital Britanico; Oncologia
Buenos Aires, Argentina, C1280AEB
Instituto De Investigaciones Clinicas Zarate
Zarate, Argentina, 2800
Australia, New South Wales
Chris O'Brien Lifehouse
Camperdown, New South Wales, Australia, 2050
St George Hospital; Cancer Care Centre
Kogarah, New South Wales, Australia, 2217
Prince of Wales Hospital; Oncology
Randwick, New South Wales, Australia, 2031
Australia, Queensland
Princess Alexandra Hospital; Division of Cancer Services
Woolloongabba, Queensland, Australia, 4102
Australia, South Australia
Queen Elizabeth Hospital; Medical Oncology
Woodville South, South Australia, Australia, 5011
Australia, Victoria
Western Hospital
Footscray, Victoria, Australia, 3011
Peninsula and South Eastern Haematology and Oncology Group
Frankston, Victoria, Australia, 3199
Cabrini Medical Centre; Oncology
Malvern, Victoria, Australia, 3144
Border Medical Oncology; Murray Valley Private Hospital
Wodonga, Victoria, Australia, 3690
Australia, Western Australia
Royal Perth Hospital; Department of Medical Oncology
Perth, Western Australia, Australia, 6000
Bosnia and Herzegovina
University Clinical Center of the Republic of Srpska
Banja Luka, Bosnia and Herzegovina, 78000
Clinic of Oncology, University Clinical Center Sarajevo
Sarajevo, Bosnia and Herzegovina, 7100
Hospital Sao Rafael - HSR
Salvador, BA, Brazil, 41253-190
Centro de Oncologia da Bahia - CENOB
Salvador, BA, Brazil, 41820-021
Hospital Moinhos de Vento
Porto Alegre, RS, Brazil, 90035-001
Hospital Amaral Carvalho
Jau, SP, Brazil, 17210-080
Instituto do Cancer do Estado de Sao Paulo - ICESP
Sao Paulo, SP, Brazil, 01246-000
Hospital Perola Byington
Sao Paulo, SP, Brazil, 01317-000
Hospital A. C. Camargo; Oncologia
Sao Paulo, SP, Brazil, 01509-010
Hospital Sao Jose
São Paulo, SP, Brazil, CEP 01321-001
Complex Oncology Center - Plovdiv First Internal Chemotherapy Department
Plovdiv, Bulgaria, 4004
MHAT Serdika; Department of medical oncology
Sofia, Bulgaria, 1303
UMHAT Queen Joanna
Sofia, Bulgaria, 1527
SHATOD - Sofia
Sofia, Bulgaria, 1784
Comprehensive Oncology Center - Vratsa
Vratza, Bulgaria, 3000
Canada, Alberta
Cross Cancer Institute ; Dept of Medical Oncology
Edmonton, Alberta, Canada, T6G 1Z2
Canada, British Columbia
British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre
Vancouver, British Columbia, Canada, V5Z 4E6
Canada, New Brunswick
Moncton Hospital
Moncton, New Brunswick, Canada, E1C 6Z8
Canada, Ontario
Lakeridge Health Oshawa; Oncology
Oshawa, Ontario, Canada, L1G 2B9
St. Michael'S Hospital
Toronto, Ontario, Canada, M5B 1W8
Windsor Regional Cancer Centre
Windsor, Ontario, Canada, N8W 2X3
Canada, Quebec
CSSS champlain - Charles-Le Moyne
Greenfield Park, Quebec, Canada, J4V 2H1
Hopital Maisonneuve- Rosemont; Oncology
Montreal, Quebec, Canada, H1T 2M4
Mcgill University - Royal Victoria Hospital; Oncology
Montreal, Quebec, Canada, H3A 1A1
Centro Oncológico Antofagasta
Antofagasta, Chile, 1240000
Instituto Nacional del Cancer
Santiago, Chile, 8380000
Sociedad de Investigaciones Medicas Ltda (SIM)
Temuco, Chile, 4810469
Hospital Carlos Van Buren, Servicio de Oncologia
Valparaiso, Chile, 2341391
Clinica del Country
Bogota, Colombia, 11001
Clínica Imbanaco; Oncology
Cali, Colombia
Clinical Hospital Osijek; Dept For Oncology & Radiotherapy
Osijek, Croatia, 31000
Clinical Hospital Centre Zagreb
Zagreb, Croatia, 10000
Masarykův onkologický ústav; Klinika komplexní onkologické péče
Brno, Czechia, 656 53
Fakultní nemocnice Olomouc
Olomouc, Czechia, 775 20
Vseobecna fakultni nemocnice v Praze
Praha 2, Czechia, 128 08
Fakultní Nemocnice V Motole; Radioterapeuticko-Onkologicke Oddeleni
Praha 5, Czechia, 150 06
Dominican Republic
Hospital Metropolitano de Santiago
Santiago, Dominican Republic, 51000
Instituto de Cáncer SOLCA Cuenca; Oncología
Cuenca, Ecuador, EC010107
Solca Guayaquil- Sociedad de Lucha Contra El Cáncer; Oncology
Guayaquil, Ecuador, EC090112
Hospital Solca Quito; Oncologia
Quito, Ecuador, EC170124
Alexandria Uni ; Medical Oncology
Alexandria, Egypt, 11737
Manial Specialized Hospital; Oncology
Cairo, Egypt, 11555
Nci; Oncology Dept
Cairo, Egypt, 11796
El Salvador
Hospital Oncologia; Oncology
Salvador, El Salvador, 01101
Satakunta Central Hospital; Oncology
Pori, Finland, 28500
CHU d'Amiens
Amiens, France, 80054
Besancon, France, 25030
Clinique Tivoli; Sce Radiotherapie
Bordeaux, France, 33000
Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie
Bordeaux, France, 33077
Ch De Fleyriat; Pneumologie 1
Bourg En Bresse, France, 01012
Hopital Augustin Morvan; Federation De Cancerologie
Brest, France, 29200
Ch De Brive La Gaillarde; Radiotherapie Oncologie
Brive La Gaillarde, France, 19312
Clinique Sainte Marie; Chimiotherapie
Chalon Sur Saone, France, 71100
Centre Jean Perrin; Hopital De Jour
Clermont Ferrand, France, 63011
Chi De Creteil; Radiotherapie Oncologie
Creteil, France, 94010
Fondation Clement Drevon; Oncology
Dijon, France, 21000
Centre Georges-François Lecler; Ctr de Lutte Contre le Canc
Dijon, France, 21034
Ch De La Dracenie; Hopital De Jour
Draguignan, France, 83007
Hopital Prive Drome Ardeche; Chir 2A 2B
Guilherand Granges, France, 07500
Clinique Sainte Marguerite; Oncologie Medicale
Hyeres, France, 83400
CHD Les Oudairies
La Roche Sur Yon, France, 85925
Hopital Albert Michallon; Oncologie
La Tronche, France, 38700
Ch Du Mans; Medecine Hematologie Oncologie
Le Mans, France, 72037
Clinique Victor Hugo
LeMans, France, 72000
Centre Hartmann
Levallois Perret, France, 92300
Polyclinique Du Bois; Centre Bourgogne
Lille, France, 59000
Hopital Claude Huriez; Medecine Interne Oncologie
Lille, France, 59037
Ch Bretagne Sud Site Scorff; Oncologie Medicale
Lorient, France, 56100
CH Bretagne Sud Site Bodelio; Oncologie Radiotherapie
Lorient, France, 56322
Ctre Consultations La Sauvegarde
Lyon, France, 69338
Hôpital Saint Joseph; Oncologie Medicale
Marseille, France, 13285
Metz Tessy, France, 74370
Hopital Clinique Claude Bernard; Oncologie Medicale
Metz, France, 57000
Clinique Clementville; Hopital De Jour
Montpellier, France, 34070
Centre Azureen De Cancerologie; Cons externes
Mougins, France, 06250
Centre Antoine Lacassagne; B3 Medecine Conventionnelle
Nice, France, 06189
Hopital Cochin; Unite Fonctionnelle D Oncologie
Paris, France, 75014
Hopital Hotel Dieu; Oncologie Medicale
Paris, France, 75181
HOPITAL TENON; Cancerologie Medicale
Paris, France, 75970
Ch Francois Mitterrand; Medecine Oncologie
Pau, France, 64046
Ch Lyon Sud; Onco Secteur Jules Courmont
Pierre Benite, France, 69495
Chp Saint Gregoire; Cancerologie Radiotherapie
Saint Gregoire, France, 35768
Ico Rene Gauducheau; Oncologie
Saint Herblain, France, 44805
Clinique de L'Union; Oncologie
Saint Jean, France, 31240
Ch De Saint Quentin; Medecine B10
Saint Quentin, France, 02321
Institut de Cancerologie de La Loire; Pneumologie
Saint-priest-en-jarez, France, 42270
CMCO De La Cote D Opale; Auberge De Jour
St Martin Boulogne, France, 62280
Clinique Chir De L Orangerie; Chimiotherapie
Strasbourg, France, 67010
Centre Paul Strauss; Oncologie Medicale
Strasbourg, France, 67065
Hopitaux Du Leman Site Thonon; Maternite Gynecologie
Thonon Les Bains, France, 74203
Institut Claudius Regaud; Departement Oncologie Medicale
Toulouse, France, 31059
Clinique Pasteur; Pneumologie
Toulouse, France, 31076
Clinique Radio Des Dentellieres; Chimiotherapie Radiotherapie
Valenciennes, France, 59326
Centre-Alexis Vautrin
Vandoeuvre-les-Nancy, France, 54511
Klinikum Augsburg; Frauenklinik
Augsburg, Germany, 86156
Internist; Praxis Für Haemotologie & Onkologie
Bad Soden, Germany, 65812
Praxis Dres. Schilling & Till
Berlin, Germany, 10317
Vivantes Klinikum Am Urban; Zentrum für Brusterkrankungen
Berlin, Germany, 10967
Katholische Hospitalvereinigung Ostwestfalen gGmbH
Bielefeld, Germany, 33615
Gemeinschaftspraxis Dr. Bueckner und Dr. Nueckel
Bochum, Germany, 44787
Klinikum Bremerhaven Reinkenheide; Frauenklinik
Bremerhaven, Germany, 27574
DONAU ISAR Klinikum Deggendorf; Frauenklinik
Deggendorf, Germany, 94469
Krankenhaus St.Joseph-Stift; Klinik für Gynäkologie
Dresden, Germany, 01307
Sana Kliniken Düsseldorf GmbH Sana Krankenhaus Gerresheim; Brustzentrum
Düsseldorf, Germany, 40625
Universitätsklinikum Essen; Zentrum Für Frauenheilkunde
Essen, Germany, 45122
Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum
Essen, Germany, 45136
Universitätsklinikum Freiburg; Frauenklinik
Freiburg, Germany, 79106
Klinikum St. Georg GmbH; Franziskus-Hospital Harderberg; Klinik für Gynaekologie und Geburtshilfe
Georgsmarienhütte, Germany, 49124
Internistisch-Onkologische Gemeinschaftspraxis; Brustzentrum Ostthüringen
Gera, Germany, 07548
Krankenhaus St. Elisabeth und St. Barbara, Klinik für Frauenheilkunde und Geburtshilfe
Halle, Germany, 06110
Universitätsklinikum Hamburg-Eppendorf; Zentrum für operative Medizin Klinik für Gynäkologie
Hamburg, Germany, 20246
Kooperatives Mammazentrum Hamburg Krankenhaus Jerusalem
Hamburg, Germany, 20357
Gynaekologisch-Onkologische Schwerpunktpraxis Prof. Dr. med. Lueck, Dr. Schrader und Dr. Noeding
Hannover, Germany, 30177
Medizinische Hochschule Hannover, Klinik für Frauenheilkunde und Geburtshilfe
Hannover, Germany, 30625
Nationales Centrum für Tumorerkrankungen (NCT) ; Gyn. Onk. Frauenklinik; Uniklinikum Heidelberg
Heidelberg, Germany, 69120
Universitätsklinikum Jena; Klinik und Poliklinik für Frauenheilkunde und Fortpflanzungsmedizin
Jena, Germany, 07747
Elisabeth-Krankenhaus Brustzentrum
Kassel, Germany, 34117
St. Elisabeth Krankenhaus Köln GmbH; Gynäkologie und Geburtshilfe
Koeln, Germany, 50935
Klinikum Kulmbach; Frauenklinik
Kulmbach, Germany, 95326
Praxis Katja Ziegler-Löhr
Köln, Germany, 50679
Kliniken der Stadt Köln gGmbH Krankenhaus Holweide; Brustzentrum
Köln, Germany, 51067
Dres. Andreas Köhler und Roswitha Fuchs
Langen, Germany, 63225
Klinikum Leverkusen; Med. Klinik III / Onkologie
Leverkusen, Germany, 51375
Klinikum Ludwigsburg; Klinik für Frauenheilkunde und Geburtshilfe
Ludwigsburg, Germany, 71640
Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Klinik für Frauenheilkunde und Geburtshilfe
Lübeck, Germany, 23538
Onkologische Schwerpunktpraxis Lübeck
Lübeck, Germany, 23562
Onkologische Gemeinschaftspraxis
Magdeburg, Germany, 39104
Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde
Mainz, Germany, 55131
Gemeinschaftspraxis Fr. Dr. med. Balser & Hr. Dr. med. Weidenbach
Marburg, Germany, 35037
Klinikum Meiningen Klinik f.Gynäkologie und Geburtshilfe
Meiningen, Germany, 98617
Klinikum Memmingen; Abt.Gynäkologie
Memmingen, Germany, 87700
Mühlenkreiskliniken; Johannes Wesling Klinikum Minden; Klinik für Frauenheilkunde und Geburtshilfe
Minden, Germany, 32429
Rotkreuzklinikum München; Frauenklinik
Muenchen, Germany, 80637
Praxis Steffi Busch
Mühlhausen, Germany, 99974
Gemeinschaftspraxis Prof. Christoph Salat und Oliver J. Stötzer
München, Germany, 80638
Klinikum rechts der Isar der TU München; Frauenklinik & Poliklinik
München, Germany, 81675
Praxis Dr. Prechtl & Dr. Kowolik; Frauenklinik
München, Germany, 81925
Universitätsklinikum Münster; Klinik für Frauenheilkunde und Geburtshilfe
Münster, Germany, 48149
Ruppiner Kliniken, Klinik fuer Gynaekologie und Geburtshilfe
Neuruppin, Germany, 16816
Klinikum Nord Frauenklinik
Nürnberg, Germany, 90419
Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe
Offenbach, Germany, 63069
medius KLINIK OSTFILDERN-RUIT; Brustzentrum
Ostfildern, Germany, 73760
St. Vincenz-Krankenhaus Paderborn; Haus 3 Frauenklinik
Paderborn, Germany, 33098
Praxis für Onkologie und Hämatologie
Recklinghausen, Germany, 45657
Agaplesion Diakonieklinikum Rotenburg
Rotenburg/Wümme, Germany, 27356
Caritas Klinik St. Theresia -Frauenklinik Brustzentrum
Saarbruecken, Germany, 66113
Leopoldina Krankenhaus der Stadt Schweinfurt GmbH
Schweinfurt, Germany, 97422
HELIOS Klinikum Schwerin; Frauenklinik
Schwerin, Germany, 19049
Johanniter-Krankenhaus Genthin-Stendal; Klinik Für Frauenheilkunde & Geburtshilfe
Stendal, Germany, 39576
Dres. Thomas Kuhn, Frank Beldermann und Angelika Ritzmann
Stuttgart, Germany, 70190
Kreiskrankenhaus Torgau; Abt.Gynäkologie und Geburtshilfe
Torgau, Germany, 04860
Universitätsklinik Tübingen; Frauenklinik
Tübingen, Germany, 72076
Katharinen-Hospital gGmbH
Unna, Germany, 59423
Kliniken Nordoberpfalz; Klinikum Weiden; Brustzentrum
Weiden, Germany, 92637
GRN-Klinik Weinheim; Abt.Gynäkologie und Geburtshilfe
Weinheim, Germany, 69469
Weißenfels, Germany, 06667
Lahn-Dill Kliniken GmbH Klinikum Wetzlar Gynäkologie/Geburtshilfe
Wetzlar, Germany, 35578
Gesellschaft für Medizinische Studien Würselen
Wuerselen, Germany, 52146
Uni Hospital of Alexandroupoli; Dept. of Oncology - Duth
Alexandroupolis, Greece, 68100
Anticancer Hospital Ag Savas; 1St Dept of Internal Medicine
Athens, Greece, 115 22
Laiko General Hospital; 1St Pathological Clinic
Athens, Greece, 115 27
Alexandras General Hospital of Athens; Oncology Department
Athens, Greece, 115 28
Periph. University General Hospital of Heraklion Crete; Oncology Department
Heraklion, Greece, 71110
Agioi Anargyroi Cancer Hospital; 2Nd Oncology Dept.
Kifisia, Greece, 145 64
University Hospital of Larissa; Oncology
Larissa, Greece, 41 110
General Hospital of Larissa; Oncology Clinic
Larissa, Greece, 41221
Papageorgiou General Hospital; Medical Oncology
Thessaloniki, Greece, 546 29
Euromedical General Clinic of Thessaloniki; Oncology Department
Thessaloniki, Greece, 546 45
Grupo Angeles
Guatemala City, Guatemala, 01015
Centro Oncológico Sixtino / Centro Oncológico SA
Guatemala, Guatemala, 01010
Hong Kong
Queen Elizabeth Hospital; Clinical Oncology
Hong Kong, Hong Kong
Prince of Wales Hosp; Dept. Of Clinical Onc
Shatin, Hong Kong
Szent Margit Hospital; Dept. of Oncology
Budapest, Hungary, 1032
Szent Imre Hospital; Dept. of Oncology
Budapest, Hungary, 1115
Orszagos Onkologiai Intezet
Budapest, Hungary, 1122
Semmelweis Egyetem Aok; Iii.Sz. Belgyogyaszati Klinika
Budapest, Hungary, 1125
Debreceni Egyetem Klinikai Kozpont ; Department of Oncology
Debrecen, Hungary, 4032
Josa Andras Korhaz; Dept of Oncoradiology
Nyíregyháza, Hungary, 4400
Pécsi Tudományegyetem Áok; Onkoterapias Intezet
Pecs, Hungary, 7624
Markusovszky Hospital
Szombathely, Hungary, 9700
Hasan Sadikin Hospital; Internal Medicine
Bandung, Indonesia, 40161
CiptoMangunkusumo Hospital; Internal Medicine
Central Jakarta, Indonesia, 10430
Soetomo Hospital; Surgery
East Java, Indonesia, 60286
Dharmais National Cancer Center
Jakarta, Indonesia, 11420
Sardjito Hospital; Instalasi Kanker Tulip
Jogjakarta, Indonesia, 55284
St Vincents University Hospital
Dublin 4, Ireland
Mater Misericordiae Uni Hospital; Oncology
Dublin, Ireland, 7
Mater Private Hospital
Dublin, Ireland, 7
St. James Hospital; Oncology
Dublin, Ireland, 8
Beaumont Hospital; Cancer Clinical Trials Unit
Dublin, Ireland, 9
Galway Uni Hospital; Oncology Dept
Galway, Ireland
University Hospital Limerick
Limerick City, Ireland
Sligo General Hospital; Oncology
Sligo, Ireland
Waterford Regional Hospital; Department Of Medical Oncology
Waterford, Ireland
Ospedale Oncologico Regionale; U.O. Oncologia Medica Ed Ematologia
Rionero in Vulture, Basilicata, Italy, 85028
Az. Osp. Mariano Santo; Centro Oncologico
Cosenza, Calabria, Italy, 87100
Azienda Ospedaliera A. Cardarelli
Napoli, Campania, Italy, 80131
Istituto Nazionale Tumori Irccs Fondazione g. PASCALE;U.O.C. Oncologia Medica Senologica
Napoli, Campania, Italy, 80131
Università degli Studi Federico II; Clinica di Oncologia Medica
Napoli, Campania, Italy, 80131
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
Meldola, Emilia-Romagna, Italy, 47014
Ospedale Regionale Di Parma; Divisione Di Oncologia Medica
Parma, Emilia-Romagna, Italy, 43100
Az. Osp. Ospedale Civile; U.O. Di Oncologia Medica Ed Ematologia
Piacenza, Emilia-Romagna, Italy, 29100
Azienda USL di Ravenna; Unità Operativa di Oncologia Medica
Ravenna, Emilia-Romagna, Italy, 48100
Ausl Frosinone - Ospedale Umberto I; Divisione Di Oncologia
Frosinone, Lazio, Italy, 03100
IFO - Istituto Regina Elena; Oncologia Medica
Roma, Lazio, Italy, 00144
Policlinico Umberto i di Roma; dip. Scienze Radiologiche, Oncologiche, Anatomopatologiche
Roma, Lazio, Italy, 00161
Azienda Ospedaliera Sant'Andrea
Roma, Lazio, Italy, 00189
Ospedale Belcolle Di Viterbo; Oncologia
Viterbo, Lazio, Italy, 01100
Asst Papa Giovanni XXIII; Oncologia Medica
Bergamo, Lombardia, Italy, 24128
Casa Di Cura S. Maria; Reparto Oncologia
Castellanza, Lombardia, Italy, 21053
ASST DI CREMONA; Unità di Patologia Mammaria Senologia e Breast Unit
Cremona, Lombardia, Italy, 26100
Fondazione IRCCS Istituto Nazionale dei Tumori; S. C. Oncologia Medica 2
Milano, Lombardia, Italy, 20133
ASST DI MONZA; Oncologia Medica
Monza, Lombardia, Italy, 20900
IRRCCS San Matteo; Dip Oncoematologico ; Divisione Oncologia
Pavia, Lombardia, Italy, 27100
IRCCS Istituto Clinico Humanitas; Oncologia
Rozzano, Lombardia, Italy, 20089
Ospedale Maggiore Della Carita; Oncologia Medica
Novara, Piemonte, Italy, 28100
A.O. Città della Salute e della Scienza - Presidio Molinette; divisione oncologia medica
Torino, Piemonte, Italy, 10126
Irccs Ist. Tumori Giovanni Paolo Ii; Dipartimento Oncologia Medica
Bari, Puglia, Italy, 70124
Ospedale Antonio Perrino; Oncologia Medica
Brindisi, Puglia, Italy, 72100
Ospedale Vito Fazzi; Div. Oncoematologia
Lecce, Puglia, Italy, 73100
IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia
San Giovanni Rotondo, Puglia, Italy, 71013
Ospedale Oncologico A.Businco; Div. Oncologia Medica II
Cagliari, Sardegna, Italy, 09121
Ospedale Civile SS Annunziata; oncologia medica
Sassari, Sardegna, Italy, 07100
Ospedale Garibaldi Nesima; Biomedicina Clinica e Molecolare
Catania, Sicilia, Italy, 95100
Fond. Ist. S. Raffaele - giglio; Farmacia
Cefalù, Sicilia, Italy, 90015
Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1
Firenze, Toscana, Italy, 50139
Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2
Pisa, Toscana, Italy, 56100
Azienda usl 5 Di Pisa-Ospedale Di Pontedera;U.O. Oncologia
Pontedera, Toscana, Italy, 56025
Ospedale Civile; Oncologia Medica
Camposampiero, Veneto, Italy, 35012
Arcispedale S.Anna; Oncologia Medica
Cona (Ferrara), Veneto, Italy, 44124
Azienda Ospedaliera di Verona-Policlinico G.B. Rossi
Verona, Veneto, Italy, 37134
Korea, Republic of
National Cancer Center
Gyeonggi-do, Korea, Republic of, 10408
Korea University Guro Hospital
Seoul, Korea, Republic of, 08308
Yonsei University Severance Hospital; Medical Oncology
Seoul, Korea, Republic of, 120-752
Asan Medical Center.
Seoul, Korea, Republic of, 138-736
Samsung Medical Center
Seoul, Korea, Republic of, 6351
Hospital of Lithuanian University of Health. Sciences Kaunas Clinics
Kaunas, Lithuania, 50009
Klaipeda University Hospital
Klaipeda, Lithuania, 92288
Hospital Pulau Pinang; Jabatan Radioterapi & Onkologi
Georgetown, Malaysia, 10990
University Malaya Medical Centre; Clinical Oncology Unit,
Kuala Lumpur, Malaysia, 59100
Hospital Wanita dan Kanak-Kanak Sabah
Sabah, Malaysia, 88996
Sarawak General Hospital; Department of Radiotherapy, Oncology and Palliative care
Sarawak, Malaysia, 93586
Hospital General de Mexico
Mexico, Tlaxcala, Mexico, 06726
Centro Estatal de Oncología de Campeche
Campeche, Mexico, 24096
Centro Estatal de Cancerología
Chihuahua, Mexico, 31000
Instituto Nacional de Cancerologia; Oncology
Distrito Federal, Mexico, 14080
Consultorio de Medicina Especializada; Dentro de Condominio San Francisco
Mexico City, Mexico, 03100
Oaxaca Site Management Organization
Oaxaca, Mexico, 68000
Cancerologia de Queretaro; Oncologia
Queretaro, Queretaro, Mexico, 76090
Centro Estatal de Cancerologia de Nayarit
Tepic, Mexico, 63170
Clinica San Francisco; Oncologia
Torreon, Mexico, 27000
Institut National D'oncologie Sidi Med Benabdellah
Rabat, Morocco, 6213
Jeroen Bosch Ziekenhuis
'S Hertogenbosch, Netherlands, 5223 GZ
Onze Lieve Vrouwe Gasthuis
AC Amsterdam, Netherlands, 1091
Gelre Ziekenhuis Apeldoorn, Lokatie Lukas; Afdeling Interne Geneeskunde
Apeldoorn, Netherlands, 7334 DZ
Rijnstate Ziekenhuis; Inwendige Geneeskunde
Arnhem, Netherlands, 6815 AD
Albert Schweitzer Ziekenhuis; Inwendige Geneeskunde
Dordrecht, Netherlands, 3318 AT
Ziekenhuis Gelderse Vallei; Inwendige Geneeskunde
EDE, Netherlands, 6716 RP
Catharina Ziekenhuis; Dept of Internal Medicin
Eindhoven, Netherlands, 5623 EJ
Maxima Medisch Centrum; Inwendige Geneeskunde
Eindhoven, Netherlands, 5631 BM
Martini Ziekenhuis; Dept of Internal Medicine
Groningen, Netherlands, 9728 NT
Atrium Medisch Centrum Parkstad, Heerlen
Heerlen, Netherlands, 6419 PC
Spaarne Ziekenhuis; Inwendige Geneeskunde
Hoofddorp, Netherlands, 2134 TM
St. Antonius Ziekenhuis Nieuwegein
Nieuwegein, Netherlands, 3430 EM
Franciscus Ziekenhuis
Roosendaal, Netherlands, 4708 AE
Maasstad ziekenhuis; Afdeling oncologie hematologie
Rotterdam, Netherlands, 3079 DZ
Ikazia Ziekenhuis
Rotterdam, Netherlands, 3083 AN
Vlietland Ziekenhuis, Locatie Schiedam; Interne Geneeskunde
Schiedam, Netherlands, 3100 AE
Zuyderland ziekenhuis locatie Geleen
Sittard-Geleen, Netherlands, 6162 BG
Diakonessenhuis Utrecht: ziekenhuisapotheek
Utrecht, Netherlands, 3582 KE
Vie Curie
Venlo, Netherlands, 5912 BL
Zaans Medisch Centrum
Zaandam, Netherlands, 1502 DV
New Zealand
Tauranga Hospital, Clinical Trials Unit; BOP Clinical School
Tauranga, New Zealand, 3112
Sørlandet Sykehus Kristiansand
Kristiansand, Norway, 4604
Oslo universitetssykehus HF, Ullevål, Kreftsenteret
Oslo, Norway, 0450
Helse Stavanger HF, Stavanger Universitetssjukehus; Klinikk for Blod og kreftsykdommer
Stavanger, Norway, 4011
Shifa International Hospital; Department of Oncology
Islamabad, Pakistan, 44000
Aga Khan University; Department of Oncology
Karachi, Pakistan, 74800
Shaukat Khanum Memorial Cancer Hospital; Department of Oncology
Lahore, Pakistan, 54000
Hameed Latif Hospital; Department of Oncology
Lahore, Pakistan, 54600
Centro Hemato Oncologico Panama
Panama, Panama, 0832
Centro Medico Monte Carmelo
Arequipa, Peru, 04001
Instituto Nacional de Enfermedades Neoplasicas
Lima, Peru, 34
Clinica de Especialidades Medicas
Lima, Peru, Lima 41
Clinica Internacional, Sede San Borja; Unidad de Investigacion de Clínica Internacional
Lima, Peru, Lima 41
Instituto Oncologico de Lima
LIma, Peru, Lima27
Philippine General Hospital; Section Of Medical Oncology
Manila, Philippines, 1000
East Avenue Medical Center
Quezon City, Philippines, 1100
Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii
Krakow, Poland, 31-531
Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii
Otwock, Poland, 05-400
Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu
Poznan, Poland, 60-569
Wielkopolskie Centrum Onkologi
Poznan, Poland, 61-866
MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska
Rzeszow, Poland, 35-021
Wojewodzki Szpital Zespolony
Torun, Poland, 87-100
NZOZ Onko-Dent SP. P. G. L. Slomian, Poradnia Onkologiczna
Zory, Poland, 44-240
Centro Clinico Champalimaud; Oncologia Medica
Lisboa, Portugal, 1400-038
Hospital da Luz; Departamento de Oncologia Medica
Lisboa, Portugal, 1500-650
IPO do Porto; Servico de Oncologia Medica
Porto, Portugal, 4200-072
Hospital de Sao Joao; Servico de Oncologia
Porto, Portugal, 4200-319
Policlinica Sfanta Maria - Oncology; Medical Oncology
Baia Mare, Romania, 430241
Central Military Hospital; Oncology
Bucharest, Romania, 010816
Institute Of Oncology Bucharest; Medical Oncology
Bucharest, Romania, 022338
Emergency University Bucharest Hospital; Oncology Department
Bucharest, Romania, 050098
Institut of Oncology Al. Trestioreanu Bucharest; Oncology Department
Bucuresti, Romania, 022328
Prof. Dr. I. Chiricuta Institute of Oncology
Cluj Napoca, Romania, 400015
Cluj Clinical County Hospital; Oncology Dept
Cluj-Napoca, Romania, 400006
SC Oncolab SRL
Craiova, Romania, 200385
Clinical Hospital 1 Craiova; Medical Oncology
Craiova, Romania, 200642
Euroclinic Center of Oncology SRL
Iasi, Romania, 700106
S.C. Life Search S.R.L; Medical Oncology Clinic
Timisoara, Romania, 300167
ONCOMED - Medical Centre
Timisoara, Romania, 300239
Russian Federation
Regional Oncology Hospital
Irkutsk, Russian Federation, 664035
City Oncological Hospital
Izhevsk, Russian Federation, 426009
Russian Oncology Research Center n.a. N.N. Blokhin Dpt of Clinical Pharmacology and Chemotherapy
Moscow, Russian Federation, 115478
City Clinical Oncology Hospital
Moscow, Russian Federation, 143423
State Inst. Of Healthcare Orenburg Regional Clinical Oncology Dis
Orenburg, Russian Federation, 460021
City Clinical Oncology Dispensary, SPb SBIH CCOD
Saint-Petersburg, Russian Federation, 198255
Bashkirian Republican Clinical Oncology Dispensary
UFA, Russian Federation, 450054
Saudi Arabia
King Faisal Specialist Hospital & Research Centre
Jeddah, Saudi Arabia, 21499
King Abdul Aziz Medical City, King Fahd National Guard; Oncology
Riyadh, Saudi Arabia, 22490
Clinical Hospital Center Bezanijska kosa; Clinic for Oncology
Belgrade, Serbia, 11000
Institute for Onc/Rad Serbia
Belgrade, Serbia, 11000
Clinical Center Kragujevac
Kragujevac, Serbia, 34000
Clinical Centre Nis, Clinic for Oncology
Nis, Serbia, 18000
Oncology Institute of Vojvodina
Sremska Kamenica, Serbia, 21204
National Cancer Centre; Medical Oncology
Singapore, Singapore, 169610
Mammacentrum sv. Agáty
Banská Bystrica, Slovakia, 974 01
National Cancer Institute - Comenius University; Dept. Clinical Oncology
Bratislava, Slovakia, 811 05
Vychodoslovensky onkologicky ustav
Kosice, Slovakia, 04001
Fakultna nemocnica s poliklinikou J.A. Reimana Presov
Presov, Slovakia, 081 81
Fakultna nemocnica Trencín; Onkologicke odd.
Trencin, Slovakia, 911 71
University Medical Centre Maribor; Depart. of Gynecology & Breast Oncology
Maribor, Slovenia, 2000
South Africa
Westridge Medical Center
Durban, South Africa, 4058
Donald Gordon Medical Centre
Johannesburg, South Africa, 2193
Steve Biko Academic Hospital; Oncology
Pretoria, South Africa, 0002
Hospital Virgen de los Lirios; Servicio de Oncologia
Alcoy, Alicante, Spain, 03804
Hospital General de Elda; Servicio de Oncologia
Elda, Alicante, Spain, 03600
Hospital de Cabueñes; Servicio de Oncologia
Gijon, Asturias, Spain, 33394
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
Badalona, Barcelona, Spain, 08916
Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
Sabadell, Barcelona, Spain, 08208
Hospital Universitario Marques de Valdecilla; Servicio de Oncologia
Santander, Cantabria, Spain, 39008
IInstituto Oncologico de San Sebastian, Oncologikoa; Servicio de Oncologia
San Sebastian, Guipuzcoa, Spain, 20014
Hospital Universitario Son Espases
Palma De Mallorca, Islas Baleares, Spain, 07014
Hospital Universitario Materno Infantil de Gran Canaria; Servicio de Oncologia
Las Palmas de Gran Canaria, LAS Palmas, Spain, 35016
Hospital de Gran Canaria Dr. Negrin; Servicio de Oncologia
Las Palmas de Gran Canaria, LAS Palmas, Spain, 35020
Hospital Do Meixoeiro; Servicio de Oncologia
Vigo, Pontevedra, Spain, 36214
Hospital Universitario de Canarias;servicio de Oncologia
La Laguna, Tenerife, Spain, 38320
Complejo Hospitalario Nuestra Señora de la Candelaria; Servicio de Oncologia
Santa Cruz de Tenerife, Tenerife, Spain, 38010
Hospital Lluis Alcanys; Servicio de Oncologia
Xativa, Valencia, Spain, 46800
Hospital de Basurto; Servicio de Oncologia
Bilbao, Vizcaya, Spain, 48013
Complejo Hospitalario Universitario de Albacete; Servicio de Oncologia
Albacete, Spain, 02006
Hospital General Univ. de Alicante; Servicio de Oncologia
Alicante, Spain, 3010
Hospital del Mar; Servicio de Oncologia
Barcelona, Spain, 08003
Centro Medico Teknon; Servicio de Oncologia
Barcelona, Spain, 08022
Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia
Barcelona, Spain, 08041
Hospital Duran i Reynals; Oncologia
Barcelona, Spain, 08907
Complejo Asistencial Universitario De Burgos; Servicio de Oncologia
Burgos, Spain, 09006
Hospital San Pedro De Alcantara; Servicio de Oncologia
Caceres, Spain, 10003
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
Jaen, Spain, 23007
Complejo Asistencial Universitario de Leon; Servicio de Oncologia
Leon, Spain, 24071
Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia
Lerida, Spain, 25198
Hospital Ramon y Cajal; Servicio de Oncologia
Madrid, Spain, 28034
Hospital Universitario Clínico San Carlos; Servicio de Oncologia
Madrid, Spain, 28040
Madrid, Spain, 28050
Hospital Quiron de Madrid; Servicio de Oncologia
Madrid, Spain, 28223
Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia
Murcia, Spain, 30120
Hospital de Navarra; Servicio de Oncologia
Navarra, Spain, 31008
Complejo Hospitalario de Toledo- H. Virgen de la Salud; Servicio de Oncologia
Toledo, Spain, 45004
Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia
Valencia, Spain, 46015
Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia
Zaragoza, Spain, 50009
Skånes University Hospital, Skånes Department of Onclology
Lund, Sweden, 22185
Skaraborgs sjukhus Skoevde, Dept of surgery
Skoevde, Sweden, 54185
Hirslanden Medical Center, Tumorzentrum
Aarau, Switzerland, 5000
Kantonsspital Baden; Frauenklinik
Baden, Switzerland, 5405
Ospedale San Giovanni; Oncologia
Bellinzona, Switzerland, 6500
Inselspital Bern; Universitätsklinik für medizinische Onkologie
Bern, Switzerland, 3010
Kantonsspital Frauenfeld, Frauenklinik Thurgau
Frauenfeld, Switzerland, 8501
CHUV; Departement d'Oncologie
Lausanne, Switzerland, 1011
Spital Thun; Medizinische Klinik
Thun, Switzerland, 3600
Kantonsspital Winterthur; Medizinische Onkologie
Winterthur, Switzerland, 8401
Stadtspital Triemli; Frauenklinik
Zürich, Switzerland, 8063
China Medical University Hospital; Surgery
Taichung, Taiwan, 404
National Cheng Kung Uni Hospital; Surgery
Tainan, Taiwan, 704
National Taiwan Uni Hospital; General Surgery
Taipei, Taiwan, 100
Tri-Service General Hospital, Division of General Surgery
Taipei, Taiwan, 114
Department of Surgery, King Chulalongkorn Memorial Hospital
Bangkok, Thailand, 10330
Oncology Unit, Faculty of Medicine, Vajira Hospital; Department of Medicine
Bangkok, Thailand, 10400
Pramongkutklao Hospital; Medicine - Medical Oncology Unit
Bangkok, Thailand, 10400
Rajvithi Hospital
Bangkok, Thailand, 10400
Ramathibodi Hospital; Medicine/Oncology
Bangkok, Thailand, 10400
Maharaj Nakorn Chiang Mai Hospital; Department of Surgery/Head Neck and Breast Unit; Clinical Trial
Chiang Mai, Thailand, 50200
Ankara Uni School of Medicine; Medical Oncology
Ankara, Turkey, 06590
Akdeniz University Medical Faculty; Medical Oncology Department
Antalya, Turkey, 07070
Dicle University Faculty of Medicine
Diyarbakir, Turkey, 21280
Gaziantep Univ. Med. Fac.
Gaziantep, Turkey, 27310
Istanbul Uni of Medicine Faculty; Oncology Dept
Istanbul, Turkey, 34390
Marmara Uni Faculty of Medicine; Medical Oncology
Istanbul, Turkey, 34890
Kocaeli University Faculty of Medicine; Medical oncology
Izmit, Turkey, 31380
TC Necmettin Erbakan University Meram Medical Faculty Hospital
Konya, Turkey, 42080
Mersin University Medical Faculty
Mersin, Turkey, 33169
19 Mayis University Medical Faculty; Medical Oncology Department
Samsun, Turkey, 55139
Hacettepe Uni Medical Faculty Hospital; Oncology Dept
Sıhhiye, Ankara, Turkey, 06100
Mun. Multifield Clin.Hosp.#4,Dept. of Chemotherapy, DSMU; Chair of Oncology and Medical Radiology
Dnipropetrovsk, Ukraine, 49102
Kyiv City Clinical Oncological Center; Chemotherapy Department
Kiev, Ukraine, 03115
State Oncology Regional Treatment-Diagnostic Center; Chemotherapy Department
Lviv, Ukraine, 79031
United Arab Emirates
Tawam Hospital
Al Ain, United Arab Emirates, 15258
United Kingdom
Aberdeen Royal Infirmary; Medical Oncology Dept
Aberdeen, United Kingdom, AB25 2ZN
Nevill Hall Hospital
Abergavenny, United Kingdom, NP7 7EG
Bedford Hospital; Oncology
Bedford, United Kingdom, MK42 9DJ
Belfast City Hospital
Belfast, United Kingdom, BT9 7AB
Wexham Park Hospital; Oncology
Berkshire, United Kingdom, SL2 4HL
University Hospital Birmingham Queen Elizabeth Hospital
Birmingham, United Kingdom, B15 2TH
Heartlands Hospital; Department Of Medicine
Birmingham, United Kingdom, B9 5SS
Royal Bournemouth Hospital; Oncology
Bournemouth, United Kingdom, BH7 7DW
Kent & Canterbury Hospital
Canterbury, United Kingdom, CT1 3NG
Broomfield Hospital; Oncology
Chelmsford, United Kingdom, CM1 7ET
Essex County Hospital; Oncology
Colchester, United Kingdom, C03 3NB
Glan Clwyd Distr Gen Hospital;Nth Wales Cancer Treatment Ctr
Denbighshire, United Kingdom, LL185UJ
Royal Derby Hospital
Derby, United Kingdom, DE22 3NE
North Devon District Hospital
Devon, United Kingdom, EX31 4JB
Russells Hall Hospital; Oncology
Dudley, United Kingdom, DY1 2HQ
Ninewells Hospital
Dundee, United Kingdom, DD12 9SY
University Hospital of North Durham
Durham, United Kingdom, DH15TW
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom, G12 0YN
Inverclyde Hospital
Greenock, United Kingdom, PA16 0XN
Diana Princess of Wales Hosp.
Grimsby, United Kingdom, DN33 2BA
Royal Surrey County Hospital
Guildford, United Kingdom, GU2 7XX
Princess Alexandra Hospital; Oncology Department
Harlow, United Kingdom, CM20 1QX
Huddersfield Royal Infirmary
Huddersfield, United Kingdom, HD3 3EA
Ipswich Hospital
Ipswich, United Kingdom, IP4 5PD
Crosshouse Hospital; Dept of Oncology
Kilmarnock, United Kingdom, KA2 0BE
Forth Valley Royal Hospital ; Oncology Department
Larbert, United Kingdom, FK5 4QE
Leicester Royal Infirmary
Leicester, United Kingdom, LE1 5WW
St John's Hospital
Livingston, United Kingdom, EH54 6PP
Guys and St Thomas NHS Foundation Trust, Guys Hospital
London, United Kingdom, SE1 9RT
Queen Elizabeth Hospital
London, United Kingdom, SE18 4QH
St George's Hospital
London, United Kingdom, SW17 0QT
Macclesfield District General Hospital
Macclesfield, United Kingdom, SK10 3BL
Christie Hospital; Breast Cancer Research Office
Manchester, United Kingdom, M20 4QL
Freeman Hospital; Northern Centre For Cancer Care
New Castle Upon Tyne, United Kingdom, NE7 7DN
Royal Gwent Hospital
Newport, United Kingdom, NP20 2UB
North Tyneside General Hospital
North Shields, United Kingdom, NE29 8NH
Northampton General Hospital NHS Trust
Northampton, United Kingdom, NN1 5BD
Derriford Hospital; Plymouth Oncology Centre
Plymouth, United Kingdom, PL6 8DH
Poole General Hospital
Poole, United Kingdom, BH15 2JB
Queen Alexandra Hospital, Portsmouth
Portsmouth, United Kingdom, PO6 3LY
Royal Preston Hospital
Preston, United Kingdom, PR2 9HT
Queens Hospital; R&D
Romford, United Kingdom, RM7 0AE
Scarborough General Hospital
Scarborough, United Kingdom, YO12 6QL
Royal Shrewsbury Hospital; Pharmacy Department
Shrewsbury, United Kingdom, SY3 8XQ
Southampton General Hospital
Southampton, United Kingdom, SO16 6YD
Sunderland Royal Hospital
Sunderland, United Kingdom, SR4 7TP
Singleton Hospital; Pharmacy Department
Swansea, United Kingdom, SA2 8QA
Great Western Hospital, Swindon Cancer Research Unit; Osprey Unit Level 3
Swindon, United Kingdom, SN3 6BB
Royal Cornwall Hospital
Truro, United Kingdom, TR1 3LQ
Royal Hampshire County Hospital; Winchester & Andover Breast Unit
Winchester, United Kingdom, SO22 5DG
The Clatterbridge Cancer Ctr For Oncolgy
Wirral, United Kingdom, CH63 4JY
The Royal Wolverhampton Hospitals NHS Trust
Wolverhampton, United Kingdom, WV10 0QP
Airedale General Hospital; Oncology
York, United Kingdom, BD20 6TD
York District Hospital
York, United Kingdom, YO31 8HE
Grupo Oncológico Cooperativo Uruguayo; Hospital de Clínicas - Dpto. de Oncología
Montevideo, Uruguay, 11400
Hospital Militar; Oncologia
Montevideo, Uruguay, 11600
Hospital Pereira Rossell; Oncology Department
Montevideo, Uruguay, 11600
Instituto Oncológico Luis Razetti
Caracas, Venezuela, 1010
Hospital Militar Dr. Carlos Arvelo.
Caracas, Venezuela, 1020
Centro Integral de Oncología
Caracas, Venezuela, 1060
Centro Médico Docente La Trinidad; Unidad de Protocolos Clínicos
Caracas, Venezuela, 1080
K hospital
Hanoi, Vietnam, 10000
Sponsors and Collaborators
Hoffmann-La Roche
Study Director: Clinical Trials Hoffmann-La Roche