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The Microcirculation in Acute Myocardial Infarction (Micro-AMI) (Micro-AMI)

This study has been completed.
Information provided by (Responsible Party):
Elisa McAlindon, University of Bristol Identifier:
First received: March 9, 2012
Last updated: October 27, 2014
Last verified: October 2014
This study investigates the association between the microvascular resistance at the time of primary percutaneous intervention, with microvascular obstruction on CMR and blood markers of myocardial damage.

Condition Intervention
Procedure: Index of microvascular resistance
Other: Cardiac magnetic resonance
Other: Blood markers

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: The Microcirculation in Acute Myocardial Infarction (Micro-AMI)

Resource links provided by NLM:

Further study details as provided by University of Bristol:

Primary Outcome Measures:
  • Microvascular obstruction [ Time Frame: DAy 2-4 ]
    Microvascular obstruction as a percentage of the left ventricle at 2-4 days.

Enrollment: 50
Study Start Date: March 2012
Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
STEMI patients
Consecutive patients presenting through the PPCI service
Procedure: Index of microvascular resistance Other: Cardiac magnetic resonance Other: Blood markers


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
STEMI attending Bristol Heart Institute via the primary PCI service

Inclusion Criteria:

  • >18 years old
  • Cardiac symptoms of > 20 mins chest pain or equivalent.
  • ECG criteria consistent with STEMI (STEMI)
  • Proceeding with percutaneous angioplasty
  • Assent/ consent to the study

Exclusion Criteria:

  • Known allergy to adenosine or gadolinium
  • Chronic atrial fibrillation
  • Renal impairment with eGFR <30
  • Contraindication to angiography
  • Contraindication to CMR (implanted pacemaker/ defibrillator, ferromagnetic metal implant/ injury, claustrophobia, obesity/ too large for CMR scanner)
  • Cardiogenic shock
  • Patients with special communication needs or altered consciousness.
  • Patients who do not give assent/consent to the study
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Please refer to this study by its identifier: NCT01552564

United Kingdom
Bristol Heart Institute
Bristol, United Kingdom, BS2 8HW
Sponsors and Collaborators
University of Bristol
  More Information

Responsible Party: Elisa McAlindon, Clinical Research Fellow, University of Bristol Identifier: NCT01552564     History of Changes
Other Study ID Numbers: 1625
Study First Received: March 9, 2012
Last Updated: October 27, 2014

Additional relevant MeSH terms:
Myocardial Infarction
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases processed this record on May 22, 2017