Trial record 1 of 1 for:    GOG-0275
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Methotrexate or Dactinomycin in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2015 by Gynecologic Oncology Group
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Gynecologic Oncology Group
ClinicalTrials.gov Identifier:
NCT01535053
First received: February 14, 2012
Last updated: March 17, 2015
Last verified: March 2015
  Purpose

This randomized phase III trial studies how well methotrexate works compared to dactinomycin in treating patients with low-risk gestational trophoblastic neoplasia. Drugs used in chemotherapy, such as methotrexate and dactinomycin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether methotrexate is more effective than dactinomycin in treating gestational trophoblastic disease.


Condition Intervention Phase
Gestational Trophoblastic Tumor
Good Prognosis Metastatic Gestational Trophoblastic Tumor
Hydatidiform Mole
Uterine Corpus Choriocarcinoma
Drug: Leucovorin Calcium
Biological: Dactinomycin
Drug: Methotrexate
Other: Quality-of-Life Assessment
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase III Randomized Trial of Pulse Actinomycin-D Versus Multi-day Methotrexate for the Treatment of Low-Risk Gestational Trophoblastic Neoplasia

Resource links provided by NLM:


Further study details as provided by Gynecologic Oncology Group:

Primary Outcome Measures:
  • Complete response vs treatment failure [ Time Frame: Up to 2 years ] [ Designated as safety issue: No ]
    The information fraction is estimated by the number of eligible patients evaluated for response at a given time divided by the target sample size of eligible patients. However, the timing of the interim analyses will likely vary from this exact schedule for practical reasons. At the interim analysis, the test statistic for the primary analysis will be compared with the critical boundaries defined by the statistical design parameters an O'Brien and Fleming alpha spending function as proposed by Lan and DeMets.


Secondary Outcome Measures:
  • Severity of adverse events as assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events version 4 [ Time Frame: Up to 2 years ] [ Designated as safety issue: Yes ]
    The maximum grade of any adverse event observed during active treatment period or within 4 weeks of completing study treatment for each eligible patient will be tabulated. The proportion of patients with a serious adverse event or reported grade 3 or worse adverse event, regardless of attribution, will be compared between the treatment regimens using a chi-square test.

  • Overall QOL as measured by Functional Assessment of Cancer Therapy - General (FACT-G) [ Time Frame: Up to 26 weeks ] [ Designated as safety issue: No ]
    A linear mixed model that accounts for the correlation among the repeated measures will be fitted for the FACT-G score adjusting for baseline score and other covariates. The patient-reported symptom measurement scores and treatment disruption on QOL will be summarized by treatment arms with the estimated means for continuous variables or frequency tables for categorical variables accompanied with 95% confidence intervals.

  • UAPI (optional) [ Time Frame: Up to 2 years ] [ Designated as safety issue: No ]
    Analyses will report predictiveness curves (with observed risk for assessing calibration) for UAPI with and without the interaction term, functions of sensitivity, specificity and risk, risk distribution by treatment outcome, and area under curve from receiver operating characteristic analysis. These analyses will help to evaluate the predictive accuracy of UAPI when predicting resistance to standard single agent therapy.


Estimated Enrollment: 384
Study Start Date: June 2012
Estimated Primary Completion Date: August 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I (leucovorin calcium and methotrexate)
Patients receive methotrexate IM on days 1, 3, 5, and 7 and leucovorin calcium PO on days 2, 4, 6, and 8 OR single agent methotrexate IV on days 1-5.
Drug: Leucovorin Calcium
Given PO
Other Name: CF
Drug: Methotrexate
Given IV and IM
Other: Quality-of-Life Assessment
Ancillary studies
Other Name: Quality of Life Assessment
Active Comparator: Arm II (dactinomycin)
Patients receive dactinomycin IV over 15 minutes on day 1.
Biological: Dactinomycin
Given IV
Other Name: Lyovac Cosmegen
Other: Quality-of-Life Assessment
Ancillary studies
Other Name: Quality of Life Assessment

Detailed Description:

PRIMARY OBJECTIVES:

I. To test the hypothesis that treatment with multi-day methotrexate is inferior to treatment with pulse actinomycin-D (dactinomycin) in patients with low-risk gestational trophoblastic disease with respect to complete response.

SECONDARY OBJECTIVES:

I. To describe the frequency of post protocol surgical treatment for each arm. II. To describe the frequency of post protocol multi-agent chemotherapy treatment for each arm.

III. To compare multi-day methotrexate to actinomycin-D with respect to frequency and severity of adverse events in patients with low-risk gestational trophoblastic neoplasia.

IV. To investigate the impact of treatment on overall quality-of-life (QOL) and explore the influence of treatment on issues such as body image, sexual functioning, and patient-reported side effects and disruption.

V. To assess whether uterine artery pulsatility index (UAPI) can provide independent prognostic information predictive of single-drug resistance.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive methotrexate intramuscularly (IM) on days 1, 3, 5, and 7 and leucovorin calcium orally (PO) on days 2, 4, 6, and 8 OR single agent methotrexate intravenously (IV) on days 1-5.

ARM II: Patients receive dactinomycin IV over 15 minutes on day 1.

In both arms, treatment repeats every 14 days for up to 20 courses* in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up monthly for 1 year and then every 3 months for 1 year.

NOTE: * Patients will be treated for three courses after human chorionic gonadotropin (hCG) < 5 mIU/mL or until evidence of treatment failure (biologic progression), disease progression, or unacceptable toxicity despite dose modifications. Upon normalization of hCG (< 5 mIU/mL), patients will be treated with three additional courses.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients who meet International Federation of Gynecology and Obstetrics (FIGO) stage I, II, or III criteria for low-risk gestational trophoblastic neoplasia (GTN): post molar GTN or choriocarcinoma (as defined below); patients may have had a second curettage but must still meet GTN criteria below:

    • Post molar GTN

      • For the purposes of this study, patients must have undergone evacuation of a complete or partial hydatidiform mole and then meet the criteria for GTN defined as:

        • A < 10% decrease in the hCG level using as a reference the first value in the series of 4 values taken over a period of 3weeks (> 50 mIU/ml minimum) OR
        • A > 20% sustained rise in the hCG taking as a reference the first value in the series of 3 values taken over a period of 2 weeks (> 50 mIU/ml minimum) OR
        • A persistently elevated hCG level a period of 6 months or more following the initial curettage (> 50 mIU/ml minimum)
    • Choriocarcinoma

      • Histologically proven non-metastatic choriocarcinoma OR
      • Histologically proven metastatic choriocarcinoma if the metastatic site(s) is restricted to one (or more) of the following: vagina, parametrium, or lung
  • World Health Organization (WHO) risk score 0-6
  • Patients must be willing to practice effective contraception for the duration of the study
  • White blood cell count (WBC) >= 3,000 cells/mcL
  • Granulocytes >= 1,500/mcL
  • Platelets >= 100,000/mcL
  • Creatinine =< 2.0 mg/dcL
  • Bilirubin =< 1.5 x institutional normal
  • Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x institutional normal
  • Alkaline phosphatase =< 3 x institutional normal
  • Patients who have met the pre-entry requirements
  • Before enrolling a patient, the institution must verify the availability of an adequate supply of methotrexate for a full course of therapy
  • Patients must have signed an approved informed consent and authorization permitting release of personal health information

Exclusion Criteria:

  • Patients who do not have GTN
  • Patients with non-gestational choriocarcinoma
  • Patients who have previously been treated with cytotoxic chemotherapy; however, patients who received prior low-dose methotrexate for treatment of an ectopic pregnancy will be eligible for this study
  • Patients who have received prior pelvic radiation
  • Patients with placental-site trophoblastic tumor (PSTT) or epithelioid trophoblastic tumor (ETT)
  • Patients with Gynecologic Oncology Group (GOG) performance status of 3 or 4
  • Patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer, are excluded if there is any evidence of other malignancy being present within the last five years; patients are also excluded if their previous cancer treatment contraindicates this protocol therapy
  • Patients whose circumstances at the time of study entry do not permit completion of the study or required follow-up
  • Patients who wish to breast-feed during treatment
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01535053

  Hide Study Locations
Locations
United States, Arizona
Saint Joseph's Hospital and Medical Center Recruiting
Phoenix, Arizona, United States, 85013
Contact: John H. Farley    877-602-4111      
Principal Investigator: John H. Farley         
United States, California
UC San Diego Moores Cancer Center Recruiting
La Jolla, California, United States, 92093
Contact: Michael T. McHale    858-822-5354    cancercto@ucsd.edu   
Principal Investigator: Michael T. McHale         
Loma Linda University Medical Center Recruiting
Loma Linda, California, United States, 92354
Contact: Yevgeniya J. Ioffe    909-558-4050      
Principal Investigator: Yevgeniya J. Ioffe         
Kaiser Permanente Los Angeles Medical Center Recruiting
Los Angeles, California, United States, 90027
Contact: Scott E. Lentz    626-564-3455      
Principal Investigator: Scott E. Lentz         
United States, Connecticut
Hartford Hospital Recruiting
Hartford, Connecticut, United States, 06102
Contact: James S. Hoffman    860-224-5660      
Principal Investigator: James S. Hoffman         
The Hospital of Central Connecticut Recruiting
New Britain, Connecticut, United States, 06050
Contact: James S. Hoffman    860-224-5660      
Principal Investigator: James S. Hoffman         
United States, Georgia
Northside Hospital Recruiting
Atlanta, Georgia, United States, 30342
Contact: Guilherme Henrique C. Cantuaria    404-303-3355    clinicaltrials@northside.com   
Principal Investigator: Guilherme Henrique C. Cantuaria         
Georgia Regents University Medical Center Recruiting
Augusta, Georgia, United States, 30912
Contact: Sharad A. Ghamande    706-721-1663    cancer@georgiahealth.edu   
Principal Investigator: Sharad A. Ghamande         
Northside Hospital-Forsyth Recruiting
Cumming, Georgia, United States, 30041
Contact: Guilherme Henrique C. Cantuaria    404-303-3355    clinicaltrials@northside.com   
Principal Investigator: Guilherme Henrique C. Cantuaria         
Dekalb Medical Center Recruiting
Decatur, Georgia, United States, 30033
Contact: Cyril O. Spann    404-501-3279      
Principal Investigator: Cyril O. Spann         
Northeast Georgia Medical Center Recruiting
Gainesville, Georgia, United States, 30501
Contact: Andrew E. Green    770-219-8800    cancerpatient.navigator@nghs.com   
Principal Investigator: Andrew E. Green         
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Recruiting
Savannah, Georgia, United States, 31405
Contact: William E. Richards    800-622-6877      
Principal Investigator: William E. Richards         
Low Country Cancer Care Associates PC Recruiting
Savannah, Georgia, United States, 31405
Contact: James J. Burke    912-350-8568      
Principal Investigator: James J. Burke         
Memorial University Medical Center Recruiting
Savannah, Georgia, United States, 31404
Contact: James J. Burke    912-350-8568      
Principal Investigator: James J. Burke         
Summit Cancer Care-Memorial Recruiting
Savannah, Georgia, United States, 31404
Contact: James J. Burke    912-350-8568      
Principal Investigator: James J. Burke         
United States, Idaho
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Illinois
Rush - Copley Medical Center Recruiting
Aurora, Illinois, United States, 60504
Contact: Kendrith M. Rowland    800-446-5532      
Principal Investigator: Kendrith M. Rowland         
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Emily Berry    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Emily Berry         
University of Chicago Comprehensive Cancer Center Recruiting
Chicago, Illinois, United States, 60637
Contact: Meaghan E. Tenney    773-834-7424      
Principal Investigator: Meaghan E. Tenney         
Carle on Vermilion Recruiting
Danville, Illinois, United States, 61832
Contact: Kendrith M. Rowland    800-446-5532      
Principal Investigator: Kendrith M. Rowland         
Carle Physician Group-Effingham Recruiting
Effingham, Illinois, United States, 62401
Contact: Kendrith M. Rowland    800-446-5532      
Principal Investigator: Kendrith M. Rowland         
Sudarshan K Sharma MD Limted-Gynecologic Oncology Recruiting
Hinsdale, Illinois, United States, 60521
Contact: Sudarshan K. Sharma    630-856-6757      
Principal Investigator: Sudarshan K. Sharma         
Carle Physician Group-Mattoon/Charleston Recruiting
Mattoon, Illinois, United States, 61938
Contact: Kendrith M. Rowland    800-446-5532      
Principal Investigator: Kendrith M. Rowland         
Good Samaritan Regional Health Center Active, not recruiting
Mount Vernon, Illinois, United States, 62864
UC Comprehensive Cancer Center at Silver Cross Recruiting
New Lennox, Illinois, United States, 60451
Contact: Meaghan E. Tenney    773-834-7424      
Principal Investigator: Meaghan E. Tenney         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Kendrith M. Rowland    800-446-5532      
Principal Investigator: Kendrith M. Rowland         
The Carle Foundation Hospital Recruiting
Urbana, Illinois, United States, 61801
Contact: Kendrith M. Rowland    800-446-5532      
Principal Investigator: Kendrith M. Rowland         
Rush-Copley Healthcare Center Recruiting
Yorkville, Illinois, United States, 60560
Contact: Kendrith M. Rowland    800-446-5532      
Principal Investigator: Kendrith M. Rowland         
United States, Indiana
Michiana Hematology Oncology PC-Elkhart Recruiting
Elkhart, Indiana, United States, 46514
Contact: Michael W. Method    574-237-1328      
Principal Investigator: Michael W. Method         
Elkhart General Hospital Terminated
Elkhart, Indiana, United States, 46515
Elkhart Clinic Terminated
Elkhart, Indiana, United States, 46514-2098
Saint Vincent Oncology Center Recruiting
Indianapolis, Indiana, United States, 46260
Contact: Michael J. Callahan    317-338-2194    research@stvincent.org   
Principal Investigator: Michael J. Callahan         
Community Howard Regional Health Terminated
Kokomo, Indiana, United States, 46904
IU Health La Porte Hospital Terminated
La Porte, Indiana, United States, 46350
Franciscan Saint Anthony Health-Michigan City Recruiting
Michigan City, Indiana, United States, 46360
Contact: Kendrith M. Rowland    800-446-5532      
Principal Investigator: Kendrith M. Rowland         
Woodland Cancer Care Center Recruiting
Michigan City, Indiana, United States, 46360
Contact: Kendrith M. Rowland    800-446-5532      
Principal Investigator: Kendrith M. Rowland         
Cancer Care Partners LLC Terminated
Mishawaka, Indiana, United States, 46545
Saint Joseph Regional Medical Center-Mishawaka Recruiting
Mishawaka, Indiana, United States, 46545
Contact: Michael W. Method    574-237-1328      
Principal Investigator: Michael W. Method         
Michiana Hematology Oncology PC-Mishawaka Recruiting
Mishawaka, Indiana, United States, 46545
Contact: Michael W. Method    574-237-1328      
Principal Investigator: Michael W. Method         
Michiana Hematology Oncology PC-Plymouth Recruiting
Plymouth, Indiana, United States, 46563
Contact: Michael W. Method    574-237-1328      
Principal Investigator: Michael W. Method         
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Michael W. Method    574-237-1328      
Principal Investigator: Michael W. Method         
Michiana Hematology Oncology PC-South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Michael W. Method    574-237-1328      
Principal Investigator: Michael W. Method         
Northern Indiana Cancer Research Consortium Recruiting
South Bend, Indiana, United States, 46628
Contact: Michael W. Method    574-237-1328      
Principal Investigator: Michael W. Method         
South Bend Clinic Terminated
South Bend, Indiana, United States, 46617
Michiana Hematology Oncology-PC Westville Recruiting
Westville, Indiana, United States, 46391
Contact: Michael W. Method    574-237-1328      
Principal Investigator: Michael W. Method         
United States, Iowa
Mercy Medical Center-Sioux City Terminated
Sioux City, Iowa, United States, 51104
Saint Luke's Regional Medical Center Terminated
Sioux City, Iowa, United States, 51104
Siouxland Hematology Oncology Associates Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
United States, Kentucky
Saint Elizabeth Medical Center South Recruiting
Edgewood, Kentucky, United States, 41017
Contact: James C. Pavelka    513-862-2230      
Principal Investigator: James C. Pavelka         
United States, Maine
Maine Medical Center-Bramhall Campus Recruiting
Portland, Maine, United States, 04102
Contact: Christopher J. Darus    207-885-7565      
Principal Investigator: Christopher J. Darus         
Maine Medical Center- Scarborough Campus Recruiting
Scarborough, Maine, United States, 04074
Contact: Christopher J. Darus    207-885-7565      
Principal Investigator: Christopher J. Darus         
United States, Maryland
University of Maryland/Greenebaum Cancer Center Withdrawn
Baltimore, Maryland, United States, 21201
Walter Reed National Military Medical Center Recruiting
Bethesda, Maryland, United States, 20889-5600
Contact: Michael P. Stany    301-319-2100      
Principal Investigator: Michael P. Stany         
United States, Massachusetts
Brigham and Women's Hospital Recruiting
Boston, Massachusetts, United States, 02115
Contact: Neil S. Horowitz    617-724-5200      
Principal Investigator: Neil S. Horowitz         
Dana-Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02115
Contact: Neil S. Horowitz    617-724-5200      
Principal Investigator: Neil S. Horowitz         
United States, Michigan
Bronson Battle Creek Recruiting
Battle Creek, Michigan, United States, 49017
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Grand Rapids Clinical Oncology Program Terminated
Grand Rapids, Michigan, United States, 49503
Mercy Health Saint Mary's Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Bronson Methodist Hospital Active, not recruiting
Kalamazoo, Michigan, United States, 49007
Borgess Medical Center Active, not recruiting
Kalamazoo, Michigan, United States, 49001
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Sunil Nagpal    269-373-7458      
Principal Investigator: Sunil Nagpal         
Mercy Health Mercy Campus Recruiting
Muskegon, Michigan, United States, 49444
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Lakeland Community Hospital Active, not recruiting
Niles, Michigan, United States, 49120
Spectrum Health Reed City Hospital Recruiting
Reed City, Michigan, United States, 49677
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Marie Yeager Cancer Center Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Michael W. Method    574-237-1328      
Principal Investigator: Michael W. Method         
Lakeland Hospital Recruiting
St. Joseph, Michigan, United States, 49085
Contact: Michael W. Method    574-237-1328      
Principal Investigator: Michael W. Method         
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
United States, Minnesota
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Hutchinson Area Health Care Recruiting
Hutchinson, Minnesota, United States, 55350
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Health Partners Inc Recruiting
Minneapolis, Minnesota, United States, 55454
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
New Ulm Medical Center Recruiting
New Ulm, Minnesota, United States, 56073
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Metro-Minnesota CCOP Terminated
Saint Louis Park, Minnesota, United States, 55416
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Minnesota Oncology and Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
United States, Missouri
Central Care Cancer Center-Carrie J Babb Cancer Center Active, not recruiting
Bolivar, Missouri, United States, 65613
CoxHealth Cancer Center Active, not recruiting
Branson, Missouri, United States, 65616
Freeman Health System Active, not recruiting
Joplin, Missouri, United States, 64804
Mercy Hospital-Joplin Active, not recruiting
Joplin, Missouri, United States, 64804
Phelps County Regional Medical Center Active, not recruiting
Rolla, Missouri, United States, 65401
Saint John's Clinic-Rolla-Cancer and Hematology Active, not recruiting
Rolla, Missouri, United States, 65401
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: David G. Mutch    800-600-3606    info@ccadmin.wustl.edu   
Principal Investigator: David G. Mutch         
Saint Louis Cancer and Breast Institute-South City Active, not recruiting
Saint Louis, Missouri, United States, 63109
Saint John's Mercy Medical Center Active, not recruiting
Saint Louis, Missouri, United States, 63141
CoxHealth South Hospital Recruiting
Springfield, Missouri, United States, 65807
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
Mercy Hospital Springfield Recruiting
Springfield, Missouri, United States, 65804
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Terminated
Springfield, Missouri, United States, 65804
United States, Montana
Montana Cancer Consortium CCOP Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Vincent Healthcare Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59107
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint James Community Hospital and Cancer Treatment Center Recruiting
Butte, Montana, United States, 59701
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Peter's Community Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Patrick Hospital - Community Hospital Recruiting
Missoula, Montana, United States, 59802
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Montana Cancer Specialists Terminated
Missoula, Montana, United States, 59802
United States, Nevada
Women's Cancer Center of Nevada Recruiting
Las Vegas, Nevada, United States, 89169
Contact: Nicola M. Spirtos    702-851-4672      
Principal Investigator: Nicola M. Spirtos         
United States, New York
State University of New York Downstate Medical Center Recruiting
Brooklyn, New York, United States, 11203
Contact: Ovadia Abulafia    718-270-8216    sima.terebelo@downstate.edu   
Principal Investigator: Ovadia Abulafia         
Memorial Sloan-Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Elizabeth L. Jewell    212-639-7202      
Principal Investigator: Elizabeth L. Jewell         
United States, North Carolina
Carolinas Medical Center Active, not recruiting
Charlotte, North Carolina, United States, 28203
Wake Forest University Health Sciences Recruiting
Winston-Salem, North Carolina, United States, 27157
Contact: Samuel S. Lentz    336-713-6771      
Principal Investigator: Samuel S. Lentz         
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center Recruiting
Akron, Ohio, United States, 44304
Contact: Vivian E. von Gruenigen    330-375-6101      
Principal Investigator: Vivian E. von Gruenigen         
Strecker Cancer Center-Belpre Recruiting
Belpre, Ohio, United States, 45714
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Adena Regional Medical Center Recruiting
Chillicothe, Ohio, United States, 45601
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Bethesda North Hospital Recruiting
Cincinnati, Ohio, United States, 45242
Contact: James C. Pavelka    513-862-2230      
Principal Investigator: James C. Pavelka         
Good Samaritan Hospital - Cincinnati Recruiting
Cincinnati, Ohio, United States, 45220
Contact: James C. Pavelka    513-862-2230      
Principal Investigator: James C. Pavelka         
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Steven E. Waggoner    800-641-2422      
Principal Investigator: Steven E. Waggoner         
Cleveland Clinic Cancer Center/Fairview Hospital Recruiting
Cleveland, Ohio, United States, 44111
Contact: Peter G. Rose    866-223-8100      
Principal Investigator: Peter G. Rose         
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Peter G. Rose    866-223-8100      
Principal Investigator: Peter G. Rose         
Doctors Hospital Recruiting
Columbus, Ohio, United States, 43228
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Columbus Oncology and Hematology Associates Inc Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Grant Medical Center Recruiting
Columbus, Ohio, United States, 43215
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Columbus CCOP Terminated
Columbus, Ohio, United States, 43215
Ohio State University Comprehensive Cancer Center Recruiting
Columbus, Ohio, United States, 43210
Contact: David M. O'Malley    800-293-5066    Jamesline@osumc.edu   
Principal Investigator: David M. O'Malley         
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Mount Carmel Health Center West Recruiting
Columbus, Ohio, United States, 43222
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Delaware Health Center-Grady Cancer Center Recruiting
Delaware, Ohio, United States, 43015
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Delaware Radiation Oncology Recruiting
Delaware, Ohio, United States, 43015
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Grady Memorial Hospital Recruiting
Delaware, Ohio, United States, 43015
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Lancaster Radiation Oncology Terminated
Lancaster, Ohio, United States, 43130
Fairfield Medical Center Recruiting
Lancaster, Ohio, United States, 43130
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Hillcrest Hospital Cancer Center Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Peter G. Rose    866-223-8100      
Principal Investigator: Peter G. Rose         
Lake University Ireland Cancer Center Recruiting
Mentor, Ohio, United States, 44060
Contact: Steven E. Waggoner    800-641-2422      
Principal Investigator: Steven E. Waggoner         
Knox Community Hospital Recruiting
Mount Vernon, Ohio, United States, 43050
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Licking Memorial Hospital Recruiting
Newark, Ohio, United States, 43055
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Newark Radiation Oncology Recruiting
Newark, Ohio, United States, 43055
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Southern Ohio Medical Center Recruiting
Portsmouth, Ohio, United States, 45662
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Springfield Regional Medical Center Recruiting
Springfield, Ohio, United States, 45505
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Saint Ann's Hospital Recruiting
Westerville, Ohio, United States, 43081
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Genesis HealthCare System Recruiting
Zanesville, Ohio, United States, 43701
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Robert S. Mannel    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Robert S. Mannel         
Tulsa Cancer Institute Recruiting
Tulsa, Oklahoma, United States, 74146
Contact: Robert S. Mannel    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Robert S. Mannel         
United States, Pennsylvania
Abington Memorial Hospital Recruiting
Abington, Pennsylvania, United States, 19001
Contact: Parviz Hanjani    215-481-2402      
Principal Investigator: Parviz Hanjani         
UPMC - HVHS Cancer Center at Heritage Valley Beaver Recruiting
Beaver, Pennsylvania, United States, 15009
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
UPMC Cancer Center at Jefferson Regional Medical Center Recruiting
Clairton, Pennsylvania, United States, 15025
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822
Contact: Radhika P. Gogoi    570-271-5251      
Principal Investigator: Radhika P. Gogoi         
UPMC Cancer Centers - Arnold Palmer Pavilion Recruiting
Greensburg, Pennsylvania, United States, 15601
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
Geisinger Medical Center-Cancer Center Hazleton Recruiting
Hazleton, Pennsylvania, United States, 18201
Contact: Radhika P. Gogoi    570-271-5251      
Principal Investigator: Radhika P. Gogoi         
UPMC-Johnstown/John P. Murtha Regional Cancer Center Recruiting
Johnstown, Pennsylvania, United States, 15901
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
UPMC Cancer Center at UPMC McKeesport Recruiting
McKeesport, Pennsylvania, United States, 15132
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
UPMC-Coraopolis/Heritage Valley Radiation Oncology Recruiting
Moon Township, Pennsylvania, United States, 15108
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
Temple University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19140
Contact: Enrique Hernandez    215-728-2983      
Principal Investigator: Enrique Hernandez         
Magee-Womens Hospital of UPMC Recruiting
Pittsburgh, Pennsylvania, United States, 15213
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
University of Pittsburgh Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
University of Pittsburgh Medical Center-Presbyterian Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15213
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
UPMC-Passavant Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15237
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
UPMC-Saint Clair Hospital Cancer Center Recruiting
Pittsburgh, Pennsylvania, United States, 15243
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
UPMC-Saint Margaret Recruiting
Pittsburgh, Pennsylvania, United States, 15215
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
UPMC-Shadyside Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
UPMC Cancer Center at UPMC Northwest Recruiting
Seneca, Pennsylvania, United States, 16346
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
Geisinger Medical Group Recruiting
State College, Pennsylvania, United States, 16801
Contact: Radhika P. Gogoi    570-271-5251      
Principal Investigator: Radhika P. Gogoi         
UPMC Uniontown Hospital Radiation Oncology Recruiting
Uniontown, Pennsylvania, United States, 15401
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
UPMC Washington Hospital Radiation Oncology Recruiting
Washington, Pennsylvania, United States, 15301
Contact: Alexander B. Olawaiye    412-647-2811      
Principal Investigator: Alexander B. Olawaiye         
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Bernice L. Robinson-Bennett    610-988-9323      
Principal Investigator: Bernice L. Robinson-Bennett         
Geisinger Wyoming Valley Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Radhika P. Gogoi    570-271-5251      
Principal Investigator: Radhika P. Gogoi         
United States, Rhode Island
Women and Infants Hospital Recruiting
Providence, Rhode Island, United States, 02905
Contact: Carolyn K. McCourt    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Carolyn K. McCourt         
United States, Tennessee
University of Tennessee - Knoxville Recruiting
Knoxville, Tennessee, United States, 37920
Contact: Larry C. Kilgore    865-544-9773      
Principal Investigator: Larry C. Kilgore         
United States, Texas
University Medical Center Brackenridge Recruiting
Austin, Texas, United States, 78701
Contact: Mark A. Crozier    512-324-7991      
Principal Investigator: Mark A. Crozier         
Parkland Memorial Hospital Recruiting
Dallas, Texas, United States, 75235
Contact: David S. Miller    214-648-7097      
Principal Investigator: David S. Miller         
University of Texas Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75390
Contact: David S. Miller    214-648-7097      
Principal Investigator: David S. Miller         
United States, West Virginia
Monongalia Hospital Recruiting
Morgantown, West Virginia, United States, 26505
Contact: Jamie L. Lesnock    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Jamie L. Lesnock         
United States, Wisconsin
Aurora Cancer Care-Burlington Recruiting
Burlington, Wisconsin, United States, 53105
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Cancer Care-Southern Lakes Recruiting
Elkhorn, Wisconsin, United States, 53121
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Health Center-Fond du Lac Recruiting
Fond Du Lac, Wisconsin, United States, 54937
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Cancer Care-Grafton Recruiting
Grafton, Wisconsin, United States, 53024
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311-6519
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Cancer Care-Kenosha South Recruiting
Kenosha, Wisconsin, United States, 53142
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Vince Lombardi Cancer Clinic-Marinette Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Advanced Healthcare Inc-Menomonee Falls Recruiting
Menomonee Falls, Wisconsin, United States, 53051
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Sinai Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53233
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Cancer Care-Milwaukee South Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Ali Mahdavi    414-649-5717    ucstudy@uci.edu   
Principal Investigator: Ali Mahdavi         
Aurora Saint Luke's Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Cancer Care-Milwaukee Recruiting
Milwaukee, Wisconsin, United States, 53209
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Cancer Center of Western Wisconsin Recruiting
New Richmond, Wisconsin, United States, 54017
Contact: Matthew P. Boente    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Matthew P. Boente         
Vince Lombardi Cancer Clinic - Oshkosh Recruiting
Oshkosh, Wisconsin, United States, 54904
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Cancer Care-Racine Recruiting
Racine, Wisconsin, United States, 53406-5661
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Vince Lombardi Cancer Clinic-Sheboygan Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Medical Center in Summit Recruiting
Summit, Wisconsin, United States, 53066
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Vince Lombardi Cancer Clinic Recruiting
Two Rivers, Wisconsin, United States, 54241
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Cancer Care-Waukesha Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora Cancer Care-Milwaukee West Recruiting
Wauwatosa, Wisconsin, United States, 53226
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
Aurora West Allis Medical Center Recruiting
West Allis, Wisconsin, United States, 53227
Contact: Ali Mahdavi    414-649-5717      
Principal Investigator: Ali Mahdavi         
United States, Wyoming
Rocky Mountain Oncology Terminated
Casper, Wyoming, United States, 82609
Welch Cancer Center Recruiting
Sheridan, Wyoming, United States, 82801
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Canada, Ontario
Odette Cancer Centre- Sunnybrook Health Sciences Centre Recruiting
Toronto, Ontario, Canada, M4N 3M5
Contact: Allan L. Covens    416-480-5000      
Principal Investigator: Allan L. Covens         
Japan
Tohoku University School of Medicine Recruiting
Sendai, Aoba-ku, Japan, 980-8574
Contact: Nobuo Yaegashi       med-som@bureau.tohoku.ac.jp   
Principal Investigator: Nobuo Yaegashi         
Kure National Hospital Recruiting
Kure, Hiroshima, Japan, 737
Contact: Takashi Sawasaki    (0823) 22-3111      
Principal Investigator: Takashi Sawasaki         
Hokkaido University Hospital Recruiting
Sapporo, Hokkaido, Japan, 060-8648
Contact: Noriaki Sakuragi       hassi@med.hokudai.ac.jp   
Principal Investigator: Noriaki Sakuragi         
Iwate Medical University School of Medicine Active, not recruiting
Morioka, Iwate, Japan, 020-8505
Niigata University Medical and Dental Hospital Recruiting
Niigata City, Niigata, Japan, 951-8520
Contact: Takayuki Enomoto    81-025-223-6161      
Principal Investigator: Takayuki Enomoto         
University of the Ryukyus Hospital-Col Health Scnc Recruiting
Nakagami-gun, Okinawa, Japan, 903-0215
Contact: Yoichi Aoki    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Yoichi Aoki         
Hiroshima University Hospital Recruiting
Hiroshima City, Japan, 734-8551
Contact: Yoshiki Kudo    82-424-6042      
Principal Investigator: Yoshiki Kudo         
Kagoshima City Hospital Recruiting
Kagoshima City, Kagoshima, Japan, 892-8580
Contact: Toshiaki Nakamura    011 81 099 224 2101      
Principal Investigator: Toshiaki Nakamura         
Kinki University Recruiting
Osaka, Osaka, Japan, 589 8511
Contact: Masaki Mandai    072-366-0221      
Principal Investigator: Masaki Mandai         
Saitama Medical University International Medical Center Recruiting
Saitama, Japan, 350-1298
Contact: Keiichi Fujiwara    81-49-276-2028      
Principal Investigator: Keiichi Fujiwara         
Tottori University Recruiting
Tottori, Japan, 680-8550
Contact: Hiroaki Itamochi    0857-31-5007      
Principal Investigator: Hiroaki Itamochi         
Korea, Republic of
Catholic University of Korea-Seoul Saint Mary's Hospital Recruiting
Seoul, Korea, Korea, Republic of, 137-040
Contact: Keun H. Lee    2258-5745-6      
Principal Investigator: Keun H. Lee         
Samsung Medical Center Recruiting
Seoul, Korea, Korea, Republic of, 135-710
Contact: Jeong-Won Lee    011-82-1599-3114      
Principal Investigator: Jeong-Won Lee         
Seoul National University Bundang Hospital Recruiting
Seongnam City, Kyeonggi-do, Korea, Republic of, 463-707
Contact: Jae Hong No    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Jae Hong No         
Asan Medical Center Recruiting
Seoul, Korea, Republic of, 138-736
Contact: Joo-Hyun Nam    011-82-760-2384      
Principal Investigator: Joo-Hyun Nam         
Gangnam Severance Hospital Active, not recruiting
Seoul, Korea, Republic of, 135-720
Korea Cancer Center Hospital Recruiting
Seoul, Korea, Republic of, 139-706
Contact: Moon-Hong Kim    011-82-02-9702-114      
Principal Investigator: Moon-Hong Kim         
Seoul National University Hospital Recruiting
Seoul, Korea, Republic of, 110-744
Contact: Hyun H. Chung    011-82-760-2384      
Principal Investigator: Hyun H. Chung         
United Kingdom
Weston Park Hospital Recruiting
Sheffield, England, United Kingdom, S10 2SJ
Contact: Robert E. Coleman    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Robert E. Coleman         
Sponsors and Collaborators
Gynecologic Oncology Group
Investigators
Principal Investigator: Julian Schink NRG Oncology
  More Information

No publications provided

Responsible Party: Gynecologic Oncology Group
ClinicalTrials.gov Identifier: NCT01535053     History of Changes
Other Study ID Numbers: GOG-0275, NCI-2012-00250, CDR0000725211, GOG-0275, GOG-0275, U10CA180868, U10CA027469
Study First Received: February 14, 2012
Last Updated: March 17, 2015
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Choriocarcinoma
Gestational Trophoblastic Disease
Hydatidiform Mole
Trophoblastic Neoplasms
Adenocarcinoma
Carcinoma
Neoplasms
Neoplasms by Histologic Type
Neoplasms, Germ Cell and Embryonal
Neoplasms, Glandular and Epithelial
Pregnancy Complications
Pregnancy Complications, Neoplastic
Dactinomycin
Leucovorin
Levoleucovorin
Methotrexate
Abortifacient Agents
Abortifacient Agents, Nonsteroidal
Anti-Bacterial Agents
Anti-Infective Agents
Antibiotics, Antineoplastic
Antidotes
Antimetabolites
Antimetabolites, Antineoplastic
Antineoplastic Agents
Antirheumatic Agents
Dermatologic Agents
Enzyme Inhibitors
Folic Acid Antagonists
Growth Substances

ClinicalTrials.gov processed this record on April 16, 2015