The Immune System's Response to Young Women's Breast Cancer
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This study plans to learn more about the immune system's response to breast cancer in young women.
Condition or disease
Breast CancerBreast Cancer and Pregnancy
The investigators will be looking at the level of immune suppression in different types of breast cancer. The investigators will use blood, urine, and tissue samples from patients with Pregnancy Associated Breast Cancer (PABC) versus non-PABC, as well as comparing different types of breast cancer. If tissue sampling permits, the investigators may use some of the breast cancer tissue to develop models for human cancer for drug targeting. Understanding the immune response and suppression in different types of cancer will help us understand mechanisms involved in breast cancer better and help the investigators in developing new treatment in the future.
Progression Free Survival [ Time Frame: Throughout study participation ]
Prospective cohort study.
Biospecimen Retention: Samples With DNA
Tissue, Blood and urine may be collected from subjects who were recently diagnosed. Subjects who were diagnosed after treatment begins or has ended will only be eligible for tissue donation section of study
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Ages Eligible for Study:
18 Years to 49 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Women who are between the ages of 18 and 49 who have been diagnosed with breast cancer. Need not be in active treatment.
Females 50 or younger
Histological or cytological confirmation of breast cancer
Any clinical stage is allowed
Any known autoimmune condition, chronic steroid use, underlying immune disease (other than breast cancer), use of immunomodulatory prescription drugs for any medical condition.
The presence of other comorbid conditions known to impact immune function, (such as: type I diabetes, uncontrolled adult onset diabetes, severe chronic obstructive pulmonary disease (COPD), uncontrolled infection or known HIV infection.)
Underlying psychiatric condition which would, in the opinion of the investigator, preclude compliance with study requirements
Diagnosed with another type of cancer within 5 years except for breast cancer, cervical or non-melanomatous skin cancer.