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A Study in Patients With Type 2 Diabetes Mellitus (IMAGINE 2)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01435616
Recruitment Status : Completed
First Posted : September 16, 2011
Results First Posted : April 13, 2018
Last Update Posted : April 13, 2018
Sponsor:
Information provided by (Responsible Party):
Eli Lilly and Company

Brief Summary:

The purpose of this study is:

  • To compare blood sugar control on LY2605541 with insulin glargine after 52 weeks of treatment.
  • To compare the rate of night time low blood sugar episodes on LY2605541 with insulin glargine during 52 weeks of treatment.
  • To compare the number of participants on LY2605541 reaching blood sugar targets without low blood sugar episodes at night to those taking insulin glargine after 52 weeks of treatment.
  • To compare the rate of low blood sugar episodes on LY2605541 with insulin glargine after 52 weeks of treatment

Condition or disease Intervention/treatment Phase
Diabetes Mellitus, Type 2 Drug: Glargine Drug: LY2605541 Phase 3

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 1538 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: A Comparison of LY2605541 Versus Insulin Glargine as Basal Insulin Treatment in Combination With Oral Anti-Hyperglycemia Medications in Insulin-Naive Patients With Type 2 Diabetes Mellitus: A Double-Blind, Randomized Study
Study Start Date : November 2011
Actual Primary Completion Date : January 2014
Actual Study Completion Date : January 2014

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: LY2605541
LY2605541 titrated based on blood glucose readings, administered subcutaneously (SC), once daily in combination with at least 2 pre-study oral antihyperglycemic medications (OAMs) prescribed by the personal physician, for 52 or 78 weeks
Drug: LY2605541
Active Comparator: Glargine
Glargine titrated based on blood glucose readings, administered SC, once daily in combination with at least 2 pre-study OAMs prescribed by the personal physician, for 52 or 78 weeks
Drug: Glargine



Primary Outcome Measures :
  1. Change From Baseline to 52 Week Endpoint in Hemoglobin A1c (HbA1c) [ Time Frame: Baseline, 52 weeks ]
    HbA1C is a test that measures a person's average blood glucose level over the past 2 to 3 months. Least Squares (LS) means were calculated using a mixed model repeated measures (MMRM) with baseline HbA1c measurement, stratification factors (country, low density lipoprotein-cholesterol [LDL-C, < 100 milligrams per deciliter {mg/dL} and ≥ 100 mg/dL] and sulfonylurea [SU]/meglitinide use), visit, treatment, and visit-by-treatment interaction as fixed effects.


Secondary Outcome Measures :
  1. Rate of Total and Nocturnal Hypoglycemia Events [ Time Frame: Baseline to 52 weeks ]
    Hypoglycemia is a condition that occurs when a person's blood glucose level is lower than the normal range (less than or equal to 70 milligrams per deciliter [mg/dL] or less than 3.9 millimoles per liter [mmol/L]). Total hypoglycemia refers to an event that meets the criteria for documented symptomatic hypoglycemia, asymptomatic hypoglycemia, probable symptomatic hypoglycemia, unspecified hypoglycemia, or severe hypoglycemia. Nocturnal hypoglycemia refers to any total hypoglycemic event that occurs between bedtime and waking. Group mean (listed as LS means below) rates of total and nocturnal hypoglycemia were calculated using a negative binomial regression model (number of episodes = treatment + SU/meglitinide use + baseline hypoglycemia event rate, with log [exposure per 30 days] as the offset variable in the model).

  2. Percentage of Participants With Hemoglobin A1c Equal or Less Than 6.5% and Less Than 7.0 % [ Time Frame: 52 weeks ]
    The percentage of participants was calculated by dividing the number of participants reaching target HbA1c by the total number of participants analyzed, multiplied by 100.

  3. Fasting Serum Glucose (By Laboratory Measurement) [ Time Frame: 52 weeks ]
    LS means were calculated using a MMRM with baseline fasting serum glucose measurement, stratification factors (country, HbA1c, LDL-C [< 100 mg/dL and ≥ 100 mg/dL], and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  4. Fasting Blood Glucose (By Participant Self-monitored Blood Glucose Readings) [ Time Frame: 52 weeks ]
    LS means were calculated using a MMRM with baseline fasting blood glucose measurement, stratification factors (country, HbA1c, LDL-C [< 100 mg/dL and ≥ 100 mg/dL], and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  5. 6 Point Self-monitored Blood Glucose (SMBG) [ Time Frame: 52 weeks ]
    Six-point SMBG profiles were obtained at pre-morning meal (fasting), pre-midday meal (lunch), pre-evening meal (dinner), bedtime, approximately 0300 hours, and pre-morning meal (fasting) the next day. Six-point SMBG profiles were obtained over 2 nonconsecutive days within the week prior to the next office visit. LS means were calculated using a MMRM with baseline blood glucose measurement, stratification factors (country, HbA1c, LDL-C [< 100 mg/dL and ≥ 100 mg/dL], and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  6. Change From Baseline to 52 Weeks in Body Weight [ Time Frame: Baseline, 52 weeks ]
    LS means were calculated using a MMRM with baseline body weight measurement, stratification factors (country, HbA1c, LDL-C [< 100 mg/dL and ≥ 100 mg/dL], and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  7. Hemoglobin A1c [ Time Frame: 52 weeks ]
    HbA1c is a test that measures a person's average blood glucose level over the past 2 to 3 months. LS means were calculated using a MMRM with baseline HbA1C measurement, stratification factors (country, HbA1c, LDL-C [< 100 mg/dL and ≥ 100 mg/dL], and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  8. Insulin Dose Per Body Weight [ Time Frame: 52 weeks ]
    LS means were calculated using a MMRM with baseline insulin dose measurement, stratification factors (country, HbA1c, LDL-C [< 100 mg/dL and ≥ 100 mg/dL], and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  9. Number of Insulin Dose Adjustments to Steady-State [ Time Frame: Baseline to 52 weeks ]
    Insulin doses were adjusted according to an algorithm (adapted from Riddle et al. 2003) during the first 26 weeks of the study and thereafter according to investigator judgment. Steady-state was defined as the first local maximum dose (maximum of moving 4-week interval) of LY2605541 or glargine within the window of +/- 2 weeks. The number of dose adjustments to steady-state was the total number of dose changes until steady-state was reached. LS means were calculated using a MMRM with baseline insulin dose measurement, stratification factors (country, HbA1c, LDL-C [< 100 mg/dL and ≥ 100 mg/dL], and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  10. European Quality of Life-5 Dimension (EQ-5D) [ Time Frame: 52 weeks ]
    The EQ-5D is a generic, multidimensional, health-related, quality-of-life instrument. The profile allows participants to rate their health state in 5 health domains (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) using a 3-level scale of 1 to 3 (no problem, some problems, and extreme problems). These combinations of attributes are converted into a weighted health-state Index Score according to the United States population-based algorithm. Scores range from -0.11 to 1.0, where a score of 1.0 indicates perfect health. LS means were calculated using a MMRM with baseline stratification factors (country, HbA1c, and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  11. Insulin Treatment Satisfaction Questionnaire [ Time Frame: Up to 52 weeks ]
    The Insulin Treatment Satisfaction Questionnaire (ITSQ) is a validated instrument containing 22 items that assess treatment satisfaction for participants with diabetes who are receiving insulin. The questionnaire measures satisfaction from the following 5 domains: inconvenience of regimen, lifestyle flexibility, glycemic control, hypoglycemic control, and insulin delivery device. Data presented are the transformed total score on a scale of 0 to 100, where higher scores indicate better treatment satisfaction. LS means were calculated using a MMRM with stratification factors (country, HbA1c, and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  12. Adult Low Blood Sugar Survey [ Time Frame: Up to 52 weeks ]
    The adult Low Blood Sugar Survey (LBSS) is a validated, participant-reported 33-item questionnaire with items rated on a 5-point Likert scale, where 0 = never and 4 = always. The LBSS measures behaviors to avoid hypoglycemia and its negative consequences (15 items) and worries about hypoglycemia and its negative consequences (18 items). Total score is the sum of all items (range of 0 to 132). Higher total scores reflect greater fear of hypoglycemia. LS means were calculated using an analysis of covariance model (ANCOVA) with baseline LBSS score, stratification factors (country, HbA1c, and SU/meglitinide use), and treatment as fixed effects.

  13. Change From Baseline to 52 Weeks in Triglycerides, Low Density Lipoprotein Cholesterol (LDL-C), and High Density Lipoprotein Cholesterol (HDL-C) [ Time Frame: Baseline, 52 weeks ]
    LS means were calculated using a MMRM with baseline lipid measurement, stratification factors (country, HbA1c, LDL-C [< 100 mg/dL and ≥ 100 mg/dL], and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  14. Percentage of Participants With Equal or Above 2-, and 3-fold Upper Limits of Normal (ULN) for Total Bilirubin [ Time Frame: Up to 52 weeks ]
  15. Overall Treatment-Emergent Anti-LY2065541 Antibody Response (TEAR) [ Time Frame: Baseline to 78 weeks ]
    The percentage of participants with a TEAR is summarized. TEAR is defined as a change in the anti-LY2605541 antibody level from undetectable at baseline to detectable at baseline, or, for those participants with detectable antibodies at baseline, change to a value with at least a 130% relative increase from baseline. Overall TEAR is defined as one or more TEAR during the specified period.

  16. Intra-participant Variability of the Fasting Blood Glucose (FBG) [ Time Frame: 52 weeks ]
    Intra-participant variability of FBG, which was measured by SMBG, was assessed by the standard deviation of the FBG measurement at the Week 52 visit. LS means were calculated using a MMRM with baseline fasting blood glucose measurement, stratification factors (country, HbA1c, LDL-C [< 100 mg/dL and ≥ 100 mg/dL], and SU/meglitinide use), treatment, visit, and treatment-by-visit interaction as fixed effects.

  17. Percentage of Participants With Total and Nocturnal Hypoglycemic Events [ Time Frame: Baseline to 52 weeks ]
    A hypoglycemic event is defined by a blood glucose value ≤70 mg/dL (3.9mmol/L). Total hypoglycemic events include documented symptomatic hypoglycemia, asymptomatic hypoglycemia, probable symptomatic hypoglycemia, unspecified hypoglycemia, or severe hypoglycemia. Nocturnal hypoglycemic events refer to any total hypoglycemic event that occurs between bedtime and waking. The percentage of participants was calculated by dividing the number of participants with hypoglycemic or nocturnal hypoglycemic events by the total number of participants analyzed, multiplied by 100.

  18. Percentage of Participants With HbA1C Equal or Less Than 6.5% and Less Than 7.0 % and Without Nocturnal Hypoglycemia [ Time Frame: Up to 52 weeks ]
    The percentage of participants with HbA1C ≤ 6.5% or < 7.0% without nocturnal hypoglycemia is presented. Percentage was calculated by dividing the number of participants with the indicated HbA1c values over the total number of participants and multiplying by 100.

  19. Percentage of Participants With Equal or Above 2- and 3-fold ULN for Alanine Transaminase/Serum Glutamic Pyruvic Transaminase (ALT/SGPT) and Aspartate Transaminase/Serum Glutamic Oxaloacetic Transaminase (AST/SGOT) [ Time Frame: Up to 52 weeks ]
    The percentage of participants was calculated by dividing the number of participants equal or above 2- or 3-fold ULN for ALT/SGPT or AST/SGOT by the total number of participants analyzed, multiplied by 100.



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Have type 2 diabetes mellitus, not treated with insulin, for at least 1 year prior to the study
  • Have been receiving at least 2 OAMs for at least 3 months before entering the study
  • Have a hemoglobin A1c (HbA1c) value between 7.0% and 11.0%, inclusive, at screening
  • Are capable of and willing to inject insulin with a vial and syringe and perform self blood glucose monitoring
  • Women of childbearing potential only: are not breastfeeding, have a negative pregnancy test at the time of screening and randomization, intend to not become pregnant during the trial, have practiced a reliable method of birth control for at least 6 weeks prior to screening, and agree to use a reliable method of birth control during the study and until 2 weeks following the last dose of study drug

Exclusion Criteria:

  • Have used insulin therapy (outside of pregnancy) anytime in the past 2 years, except for short-term treatment of acute conditions, and up to a maximum of 4 continuous weeks
  • Use of rosiglitazone, pramlintide, or glucagon-like peptide 1 (GLP-1) receptor agonist (for example, exenatide, exenatide once weekly, or liraglutide) concurrently or within 3 months prior to screening
  • Are currently taking, or have taken within the 3 months preceding screening, medications to promote weight loss
  • Have had any episodes of severe hypoglycemia within 6 months prior to screening
  • Have had 1 or more episodes of ketoacidosis or hyperosmolar state/coma in the 6 months prior to the study
  • Have cardiac disease with functional status that is New York Heart Association Class III or IV (per New York Heart Association [NYHA] Cardiac Disease Classification)
  • Have a history of renal transplantation, or are currently receiving renal dialysis or have serum creatinine greater or equal than 2 milligrams per deciliter (mg/dL)
  • Have obvious clinical signs or symptoms of liver disease (excluding non- alcoholic fatty liver disease [NAFLD]), acute or chronic hepatitis, non-alcoholic steatohepatitis (NASH), or elevated liver enzyme measurements at screening
  • Have had a blood transfusion or severe blood loss within 3 months prior to screening or have known hemoglobinopathy, hemolytic anemia or sickle cell anemia, or any other traits of hemoglobin abnormalities known to interfere with the measurement of HbA1c
  • Have active or untreated malignancy or have been in remission from clinically significant malignancy for less than 5 years
  • Have fasting or non-fasting triglycerides greater than 400 mg/dL (greater than 4.5 millimoles per liter [mmol/L]) at screening
  • Are using lipid-lowering medication at a dose that has not been stable for 90 days prior to screening
  • Are using niacin preparations as a lipid lowering medication and bile acid sequestrants within 90 days prior to screening

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01435616


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Locations
United States, Alabama
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Anniston, Alabama, United States, 36207
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Mobile, Alabama, United States, 36608
United States, Arizona
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Chandler, Arizona, United States, 85224
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Mesa, Arizona, United States, 85206
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Tempe, Arizona, United States, 85283
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Tucson, Arizona, United States, 85704
United States, California
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Concord, California, United States, 94520
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Escondido, California, United States, 92026
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Fresno, California, United States, 93720
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Greenbrae, California, United States, 94904
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Huntington Beach, California, United States, 92648
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Lancaster, California, United States, 93534
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Los Angeles, California, United States, 90057
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Mission Viejo, California, United States, 92691
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Northridge, California, United States, 91324
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Palm Springs, California, United States, 92262
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San Mateo, California, United States, 94401
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Tustin, California, United States, 92780
United States, Colorado
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Denver, Colorado, United States, 80246
United States, Florida
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Daytona Beach, Florida, United States, 32117
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Jacksonville, Florida, United States, 32258
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Tampa, Florida, United States, 33619
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Winter Haven, Florida, United States, 33880
United States, Georgia
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Athens, Georgia, United States, 30606
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Atlanta, Georgia, United States, 30338
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Decatur, Georgia, United States, 30033
United States, Hawaii
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Honolulu, Hawaii, United States, 96814
United States, Idaho
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Idaho Falls, Idaho, United States, 83404
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Meridian, Idaho, United States, 83646
United States, Illinois
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Chicago, Illinois, United States, 60607
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Springfield, Illinois, United States, 62704
United States, Iowa
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West Des Moines, Iowa, United States, 50266
United States, Kansas
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Topeka, Kansas, United States, 66606
United States, Louisiana
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Shreveport, Louisiana, United States, 71103
United States, Maine
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Bangor, Maine, United States, 04401
United States, Massachusetts
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Haverhill, Massachusetts, United States, 01830
United States, Missouri
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Saint Louis, Missouri, United States, 63141
United States, Montana
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Billings, Montana, United States, 59102
United States, New Hampshire
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Nashua, New Hampshire, United States, 03063
United States, New Jersey
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Toms River, New Jersey, United States, 08753
United States, Ohio
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Cincinnati, Ohio, United States, 45236
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Gallipolis, Ohio, United States, 45631
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Perrysburg, Ohio, United States, 43551
United States, Oregon
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Corvallis, Oregon, United States, 97330
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Springfield, Oregon, United States, 97477
United States, Pennsylvania
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Beaver, Pennsylvania, United States, 15009
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Downingtown, Pennsylvania, United States, 19335
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Lansdale, Pennsylvania, United States, 19446
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Levittown, Pennsylvania, United States, 19056
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Philadelphia, Pennsylvania, United States, 19107
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Pottstown, Pennsylvania, United States, 19464
United States, South Carolina
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Greer, South Carolina, United States, 29651
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Myrtle Beach, South Carolina, United States, 29572
United States, Tennessee
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Bristol, Tennessee, United States, 37620
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Knoxville, Tennessee, United States, 37912
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Memphis, Tennessee, United States, 38119
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Spring Hill, Tennessee, United States, 37174
United States, Texas
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Austin, Texas, United States, 78758
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Marshall, Texas, United States, 75670
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Sugar Land, Texas, United States, 77478
United States, Utah
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Bountiful, Utah, United States, 84010
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Clinton, Utah, United States, 84015
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Ogden, Utah, United States, 84403
United States, Washington
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Olympia, Washington, United States, 98502
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Port Orchard, Washington, United States, 98366
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Spokane, Washington, United States, 99220
Argentina
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Buenos Aires, Argentina, C1188AAF
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Caba, Argentina, 2000
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Córdoba, Argentina, X5000BNB
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Mar Del Plata, Argentina, B7600GNY
Australia, New South Wales
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Merewether, New South Wales, Australia, 2291
Australia, South Australia
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Keswick, South Australia, Australia, 5035
Australia, Victoria
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Box Hill, Victoria, Australia, 3128
Australia, Western Australia
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Fremantle, Western Australia, Australia, 6160
Brazil
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Marilia, Brazil, 17519-000
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Rio De Janeiro, Brazil, 22271-100
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Setor Oeste/Goiania, Brazil, 74100-120
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São Paulo, Brazil, 04266-010
Canada, Alberta
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Edmonton, Alberta, Canada, T5J 3N4
Canada, British Columbia
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Kelowna, British Columbia, Canada, V1Y 1Z9
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Victoria, British Columbia, Canada, V8V 3N7
Canada, Manitoba
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Winnipeg, Manitoba, Canada, R3P 3P4
Canada, Ontario
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Etobicoke, Ontario, Canada, M9R 4E1
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Markham, Ontario, Canada, L6B 0P9
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Toronto, Ontario, Canada, M9W 4L6
Canada, Quebec
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Laval, Quebec, Canada, H7T 2P5
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Pointe-Claire, Quebec, Canada, H9R 4S3
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Sherbrooke, Quebec, Canada, J1G 5K2
Finland
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Oulu, Finland, 90100
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Seinajoki, Finland, 60220
Germany
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Dippoldiswalde, Germany, 01744
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Dresden, Germany, 01307
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Friedrichsthal, Germany, 66299
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Furth Im Wald, Germany, 93437
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Goch, Germany, 47574
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Hamburg, Germany, D-22587
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Ludwigshafen, Germany, 67059
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Münster, Germany, 48143
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Saarbrücken, Germany, 66121
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Schweinfurt, Germany, 97421
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Sulzbach, Germany, 92237
Greece
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Ampelokipoi, Greece, 11527
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Athens, Greece, 11527
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Thessaloniki, Greece, 56429
Hungary
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Budapest, Hungary, H-1139
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Debrecen, Hungary, 4032
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Mako, Hungary, 6900
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Salgotarjan, Hungary, 3100
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Sopron, Hungary, 9400
Israel
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Beer Sheva, Israel, 84350
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Haifa, Israel, 35251
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Raanana, Israel, 43452
Italy
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Carpi, Italy, 41012
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Castellanza, Italy, 21053
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Foggia, Italy, 71100
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Forli, Italy, 47100
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Rome, Italy, 00133
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Sesto San Giovanni, Italy, 20099
Lithuania
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Utena, Lithuania, 28151
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Vilnius, Lithuania, LT-08661
Mexico
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Coatzacoalcos, Mexico, 96400
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Mexico City, Mexico, 11550
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Monterrey, Mexico, 64620
New Zealand
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Auckland, New Zealand, 1640
Poland
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Kamieniec Zabkowicki, Poland, 57-230
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Katowice, Poland, 40-772
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Krakow, Poland, 31-455
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Lodz, Poland, 93-338
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Ruda Slaska, Poland, 41-709
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Szczecin, Poland, 70-506
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Tychy, Poland, 43-100
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Warsaw, Poland, 01-192
Puerto Rico
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Hato Rey, Puerto Rico, 00917
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Manati, Puerto Rico, 00674
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San Juan, Puerto Rico, 00917-3104
Romania
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Bucharest, Romania, 011234
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Cluj-Napoca, Romania, 400006
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Iasi, Romania, 700547
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Oradea, Romania, 410169
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Ploiesti, Romania, 100342
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Resita, Romania, 320076
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Targu-Mures, Romania, 540098
Russian Federation
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Cheboksary, Russian Federation, 428000
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Kazan, Russian Federation, 420012
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Kursk, Russian Federation, 303035
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Novosibirsk, Russian Federation, 630091
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Saint Petersburg, Russian Federation, 193257
Slovakia
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Bratislava, Slovakia, 82102
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Sala, Slovakia, 92701
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Vranov Nad Toplou, Slovakia, 09301
South Africa
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Paarl, South Africa, 7646
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Parow, South Africa, 7505
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Somerset West, South Africa, 7130
Spain
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Alicante, Spain, 03114
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Cordoba, Spain, 14004
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Pozuelo De Alarcon, Spain, 28223
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Requena, Spain, 46340
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Seville, Spain, 41003
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Toledo, Spain, 45004
Turkey
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Gaziantep, Turkey, 27070
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Hatay, Turkey, 31040
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Izmir, Turkey, 35340
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Kayseri, Turkey, 38039
United Kingdom
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Mortimer, Berks, United Kingdom, RG7 3SQ
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Leicester, Leicestershire, United Kingdom, LE5 4PW
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Guildford, Surrey, United Kingdom, GU2 7XX
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Swansea, Wales, United Kingdom, SA6 6NL
Sponsors and Collaborators
Eli Lilly and Company
Investigators
Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) Eli Lilly and Company

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Eli Lilly and Company
ClinicalTrials.gov Identifier: NCT01435616     History of Changes
Other Study ID Numbers: 12141
I2R-MC-BIAJ ( Other Identifier: Eli Lilly and Company )
First Posted: September 16, 2011    Key Record Dates
Results First Posted: April 13, 2018
Last Update Posted: April 13, 2018
Last Verified: March 2018

Keywords provided by Eli Lilly and Company:
diabetes mellitus
type 2 diabetes mellitus
insulin naive
insulin treatment

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Insulin, Globin Zinc
Insulin
Insulin Glargine
Hypoglycemic Agents
Physiological Effects of Drugs