Rituximab, Bendamustine Hydrochloride, and Bortezomib Followed by Rituximab and Lenalidomide in Treating Older Patients With Previously Untreated Mantle Cell Lymphoma

This study is currently recruiting participants. (see Contacts and Locations)
Verified October 2014 by Eastern Cooperative Oncology Group
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Eastern Cooperative Oncology Group
ClinicalTrials.gov Identifier:
NCT01415752
First received: August 11, 2011
Last updated: March 13, 2015
Last verified: October 2014
  Purpose

RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and help kill them or carry cancer-killing substances to them. Others interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as bendamustine hydrochloride, also work in different ways to kill cancer cells or stop them from dividing. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide may stop the growth of mantle cell lymphoma by blocking blood flow to the cancer. It is not yet known whether giving rituximab together with bendamustine and bortezomib is more effective than rituximab and bendamustine, followed by rituximab alone or with lenalidomide in treating mantle cell lymphoma.

PURPOSE: This randomized phase II trial studies rituximab, bortezomib, bendamustine, and lenalidomide in treating previously untreated older patients with mantle cell lymphoma.


Condition Intervention Phase
Lymphoma
Neurotoxicity
Therapy-related Toxicity
Biological: rituximab
Drug: bendamustine hydrochloride
Drug: bortezomib
Drug: lenalidomide
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Intergroup Randomized Phase 2 Four Arm Study In Patients ≥ 60 With Previously Untreated Mantle Cell Lymphoma Of Therapy With: Arm A = Rituximab+ Bendamustine Followed By Rituximab Consolidation (RB → R); Arm B = Rituximab + Bendamustine + Bortezomib Followed By Rituximab Consolidation (RBV→ R), Arm C = Rituximab + Bendamustine Followed By Lenalidomide + Rituximab Consolidation (RB → LR) or Arm D = Rituximab + Bendamustine + Bortezomib Followed By Lenalidomide + Rituximab Consolidation (RBV → LR)

Resource links provided by NLM:


Further study details as provided by Eastern Cooperative Oncology Group:

Primary Outcome Measures:
  • 2-year PFS rate of patients treated with RBV to an induction regimen of RB compared to RB alone [ Designated as safety issue: No ]
  • PFS improvement of patients treated with lenalidomide added to a consolidation regimen [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • PET-documented CR rate [ Designated as safety issue: No ]
  • Response rate to RB and RBV [ Designated as safety issue: No ]
  • Toxicity [ Designated as safety issue: Yes ]
  • Quality of life [ Designated as safety issue: No ]

Estimated Enrollment: 332
Study Start Date: May 2012
Estimated Primary Completion Date: April 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm A
Patients receive induction therapy comprising rituximab IV on day 1 and bendamustine hydrochloride IV over 60 minutes on days 1-2. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then proceed to arm E.
Biological: rituximab
Given IV
Drug: bendamustine hydrochloride
Given IV
Experimental: Arm B
Patients receive induction therapy comprising bortezomib IV subcutaneously (SC) on days 1, 4, 8, and 11 and rituximab and bendamustine hydrochloride as patients in arm A. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then proceed to arm F.
Biological: rituximab
Given IV
Drug: bendamustine hydrochloride
Given IV
Drug: bortezomib
Given IV or SC
Experimental: Arm C
Patients receive induction therapy comprising rituximab and bendamustine hydrochloride as patients in arm A. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then proceed to arm G.
Biological: rituximab
Given IV
Drug: bendamustine hydrochloride
Given IV
Drug: lenalidomide
Given PO
Experimental: Arm D
Patients receive bortezomib, rituximab, and bendamustine hydrochloride as patients in arm B. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then proceed to arm H.
Biological: rituximab
Given IV
Drug: bendamustine hydrochloride
Given IV
Drug: bortezomib
Given IV or SC
Drug: lenalidomide
Given PO
Experimental: Arm E
Patients receive consolidation therapy comprising rituximab IV on day 1. Courses repeat every 8 weeks for 2 years in the absence of disease progression or unacceptable toxicity.
Biological: rituximab
Given IV
Experimental: Arm F
Patients receive consolidation therapy comprising rituximab IV on day 1. Courses repeat every 8 weeks for 2 years in the absence of disease progression or unacceptable toxicity.
Biological: rituximab
Given IV
Experimental: Arm G
Patients receive consolidation therapy comprising lenalidomide orally (PO) daily on days 1-21 every 4 weeks and rituximab IV every 8 weeks for 2 years in the absence of disease progression or unacceptable toxicity.
Biological: rituximab
Given IV
Drug: lenalidomide
Given PO
Experimental: Arm H
Patients receive consolidation therapy comprising lenalidomide PO daily on days 1-21 every 4 weeks and rituximab IV every 8 weeks for 2 years in the absence of disease progression or unacceptable toxicity.
Biological: rituximab
Given IV
Drug: lenalidomide
Given PO

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   60 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed untreated mantle cell lymphoma (MCL), with documented cyclin D1 by immunohistochemical stains and/or t(11;14) by cytogenetics or fluorescence in situ hybridization (FISH)
  • Patients must have at least one objective measurable disease parameter

    • Abnormal PET scans will not constitute evaluable disease, unless verified by CT scan or other appropriate imaging
    • Measurable disease in the liver is required if the liver is the only site of lymphoma
  • Patient must have no CNS involvement

PATIENT CHARACTERISTICS:

  • ECOG performance status 0-2
  • ANC ≥ 1,500/mcL (1.5 x 10^9/L)*
  • Platelets ≥ 100,000/mcL (100 x 10^9/L)* NOTE: *Unless due to marrow involvement.
  • AST/ALT ≤ 2 times upper limit of normal (ULN)
  • Bilirubin ≤ 2 times ULN
  • Calculated creatinine clearance by Cockroft-Gault formula ≥ 30 mL/min
  • Women (sexually mature female) must not be pregnant or breast-feeding
  • Negative pregnancy test
  • Women of childbearing potential and sexually active males use an accepted and effective method of contraception

    • Men must agree to use a latex condom during sexual contact with a female of child-bearing potential, even if they have had a successful vasectomy
    • All patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure
  • No evidence of prior malignancy except adequately treated non-melanoma skin cancer, in situ cervical carcinoma, or any surgically or radiation-cured malignancy continuously disease free for ≥ 5 years so as not to interfere with interpretation of radiographic response
  • Patient agrees that if randomized to Arms C or D, and proceed onto Arms G or H, they must register into the mandatory RevAssist® program, and be willing and able to comply with the requirements of RevAssist®

    • Patients must have no medical contra-indications to, and be willing to take, deep vein thrombosis (DVT) prophylaxis as all patients registering to the lenalidomide/rituximab Arms G and H will be required to have DVT prophylaxis

      • Patients randomized to Arms G or H who have a history of a thrombotic vascular event will be required to have therapeutic doses of low-molecular weight heparin or warfarin to maintain an INR between 2.0 - 3.0
      • Patients on Arms G and H without a history of a thromboembolic event are required to take a daily aspirin (81 mg or 325 mg) for DVT prophylaxis

        • Patients who are unable to tolerate aspirin should receive low molecular weight heparin therapy or warfarin treatment
    • Women must agree to abstain from donating blood during study participation and for at least 28 days after discontinuation from protocol treatment
    • Males must agree to abstain from donating blood, semen, or sperm during study participation and for at least 28 days after discontinuation from protocol treatment
  • HIV-positive patients are not excluded but, to enroll, must meet all of the below criteria:

    • HIV is sensitive to antiretroviral therapy
    • Must be willing to take effective antiretroviral therapy, if indicated
    • No history of CD4 prior to or at the time of lymphoma diagnosis < 300 cells/mm³
    • No history of AIDS-defining conditions
    • If on antiretroviral therapy, must not be taking zidovudine or stavudine
    • Must be willing to take prophylaxis for Pneumocystis jiroveci pneumonia (PCP) during therapy and until at least 2 months following the completion of therapy or until the CD4 cells recover to over 250 cells/mm³, whichever occurs later
  • Patients must not have grade 2 or greater peripheral neuropathy
  • Patients must not have NYHA Class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia
  • Patients must not have hypersensitivity to bortezomib, boron, or mannitol
  • Patients must not have a serious medical or psychiatric illness likely to interfere with study participation

PRIOR CONCURRENT THERAPY:

  • No prior therapy for MCL, except < 1 week of steroid therapy for symptom control
  • HIV-positive patients are not excluded, but to enroll, must meet all of the below criteria:

    • Must be willing to take effective antiretroviral therapy if indicated
    • If on antiretroviral therapy, must not be taking zidovudine or stavudine
  • Patients must not be participating in any other clinical trial or taking any other experimental medications within 14 days prior to registration
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01415752

  Hide Study Locations
Locations
United States, Alaska
Providence Alaska Medical Center Recruiting
Anchorage, Alaska, United States, 99508
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Alaska Women's Cancer Care Recruiting
Anchorage, Alaska, United States, 99508
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Anchorage Oncology Centre Recruiting
Anchorage, Alaska, United States, 99508
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Katmai Oncology Group Recruiting
Anchorage, Alaska, United States, 99508
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Alaska Breast Care and Surgery LLC Recruiting
Anchorage, Alaska, United States, 99508
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
United States, California
Kaiser Permanente-Deer Valley Medical Center Recruiting
Antioch, California, United States, 94531
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente, Fremont Recruiting
Fremont, California, United States, 94538
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente Recruiting
Fresno, California, United States, 93720
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Los Angeles County-USC Medical Center Active, not recruiting
Los Angeles, California, United States, 90033
USC / Norris Comprehensive Cancer Center Active, not recruiting
Los Angeles, California, United States, 90033
Kaiser Permanente-Modesto Recruiting
Modesto, California, United States, 95356
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-Oakland Recruiting
Oakland, California, United States, 94611
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-Redwood City Recruiting
Redwood City, California, United States, 94063
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-Richmond Recruiting
Richmond, California, United States, 94801
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-Roseville Recruiting
Roseville, California, United States, 95661
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente - Sacramento Recruiting
Sacramento, California, United States, 95825
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-South Sacramento Recruiting
Sacramento, California, United States, 95823
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-San Francisco Recruiting
San Francisco, California, United States, 94115
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-Santa Teresa-San Jose Recruiting
San Jose, California, United States, 95119
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente San Leandro Recruiting
San Leandro, California, United States, 94577
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-San Rafael Recruiting
San Rafael, California, United States, 94903
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente Medical Center - Santa Clara Recruiting
Santa Clara, California, United States, 95051
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-Santa Rosa Recruiting
Santa Rosa, California, United States, 95403
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-South San Francisco Recruiting
South San Francisco, California, United States, 94080
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Stanford University Hospitals and Clinics Active, not recruiting
Stanford, California, United States, 94305
Kaiser Permanente-Stockton Recruiting
Stockton, California, United States, 95210
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente Medical Center-Vacaville Recruiting
Vacaville, California, United States, 95688
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-Vallejo Recruiting
Vallejo, California, United States, 94589
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-Walnut Creek Recruiting
Walnut Creek, California, United States, 94596
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
United States, Colorado
Rocky Mountain Cancer Centers-Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
The Medical Center of Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Boulder Recruiting
Boulder, Colorado, United States, 80304
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Penrose Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Saint Joseph Hospital Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Cancer Research Program CCOP Recruiting
Denver, Colorado, United States, 80224-2522
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Blood Cancer Institute Recruiting
Denver, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Kaiser Permanente-Franklin Recruiting
Denver, Colorado, United States, 80205
Contact: Alexander Menter    303-614-1300      
Principal Investigator: Alexander Menter         
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Presbyterian - Saint Lukes Medical Center - Health One Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Midtown Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Rose Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rose Medical Center Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Mercy Medical Center Recruiting
Durango, Colorado, United States, 81301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Southwest Oncology PC Recruiting
Durango, Colorado, United States, 81301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Comprehensive Cancer Care and Research Institute of Colorado LLC Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Front Range Cancer Specialists Withdrawn
Fort Collins, Colorado, United States, 80528
Poudre Valley Hospital Recruiting
Fort Collins, Colorado, United States, 80524
Contact: Regina J. Brown    970-297-6150      
Principal Investigator: Regina J. Brown         
Mountain Blue Cancer Care Center Recruiting
Golden, Colorado, United States, 80401
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Greenwood Village Recruiting
Greenwood Village, Colorado, United States, 80111
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Kaiser Permanente-Rock Creek Recruiting
Lafayette, Colorado, United States, 80026
Contact: Alexander Menter    303-614-1300      
Principal Investigator: Alexander Menter         
Saint Anthony Hospital Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Lakewood Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Littleton Recruiting
Littleton, Colorado, United States, 80120
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Sky Ridge Medical Center Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Sky Ridge Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Kaiser Permanente-Lone Tree Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Alexander Menter    303-614-1300      
Principal Investigator: Alexander Menter         
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Longmont Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Parker Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Parker Adventist Hospital Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers - Pueblo Recruiting
Pueblo, Colorado, United States, 81008
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Mary Corwin Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Thornton Recruiting
Thornton, Colorado, United States, 80260
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
United States, Connecticut
Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
United States, Delaware
Beebe Medical Center Recruiting
Lewes, Delaware, United States, 19958
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Medical Oncology Hematology Consultants PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Christiana Gynecologic Oncology LLC Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Delaware Clinical and Laboratory Physicians PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Helen F Graham Cancer Center Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Regional Hematology and Oncology PA Recruiting
Newark, Delaware, United States, 19713
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Beebe Health Campus Recruiting
Rehoboth Beach, Delaware, United States, 19971
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Nanticoke Memorial Hospital Recruiting
Seaford, Delaware, United States, 19973
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
Christiana Care Health System-Wilmington Hospital Recruiting
Wilmington, Delaware, United States, 19801
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
United States, District of Columbia
Lombardi Comprehensive Cancer Center at Georgetown University Recruiting
Washington, District of Columbia, United States, 20057
Contact: Bruce D. Cheson    202-444-0381      
Principal Investigator: Bruce D. Cheson         
United States, Florida
Baptist Cancer Institute Active, not recruiting
Jacksonville, Florida, United States, 32207
UF Cancer Center at Orlando Health Recruiting
Orlando, Florida, United States, 32806
Contact: Jose E. Sarriera    321-841-7246    CancerClinicalTrials@orlandohealth.com   
Principal Investigator: Jose E. Sarriera         
United States, Hawaii
Oncare Hawaii Inc-Pali Momi Recruiting
Aiea, Hawaii, United States, 96701
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Pali Momi Medical Center Recruiting
Aiea, Hawaii, United States, 96701
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Kaiser Permanente Moanalua Medical Center Recruiting
Honolulu, Hawaii, United States, 96819
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kapiolani Medical Center for Women and Children Recruiting
Honolulu, Hawaii, United States, 96826
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Oncare Hawaii Inc-Kuakini Recruiting
Honolulu, Hawaii, United States, 96817
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
University of Hawaii Cancer Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
OnCare Hawaii-Liliha Recruiting
Honolulu, Hawaii, United States, 96817-3169
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Queen's Medical Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Straub Clinic and Hospital Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Oncare Hawaii Inc-POB II Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Castle Medical Center Terminated
Kailua, Hawaii, United States, 96734
Wilcox Memorial Hospital and Kauai Medical Clinic Recruiting
Lihue, Hawaii, United States, 96766
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Idaho Urologic Institute-Meridian Active, not recruiting
Meridian, Idaho, United States, 83642
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Kootenai Cancer Recruiting
Sandpoint, Idaho, United States, 83864
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Illinois
Memorial Hospital of Carbondale Recruiting
Carbondale, Illinois, United States, 62902
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Centralia Oncology Clinic Recruiting
Centralia, Illinois, United States, 62801
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Jane N. Winter    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Jane N. Winter         
Hematology and Oncology Associates Terminated
Chicago, Illinois, United States, 60611
John H Stroger Jr Hospital of Cook County Recruiting
Chicago, Illinois, United States, 60612-3785
Contact: Luis D. Sumoza Benitez    312-864-6000      
Principal Investigator: Luis D. Sumoza Benitez         
Mount Sinai Hospital Medical Center Active, not recruiting
Chicago, Illinois, United States, 60608
Carle on Vermilion Recruiting
Danville, Illinois, United States, 61832
Contact: Maria T. Grosse-Perdekamp    800-446-5532      
Principal Investigator: Maria T. Grosse-Perdekamp         
Cancer Care Center of Decatur Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Carle Physician Group-Effingham Recruiting
Effingham, Illinois, United States, 62401
Contact: Maria T. Grosse-Perdekamp    800-446-5532      
Principal Investigator: Maria T. Grosse-Perdekamp         
Crossroads Cancer Center Recruiting
Effingham, Illinois, United States, 62401
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Hematology Oncology Associates of Illinois-Highland Park Recruiting
Highland Park, Illinois, United States, 60035
Contact: Jane N. Winter    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Jane N. Winter         
Presence Saint Mary's Hospital Recruiting
Kankakee, Illinois, United States, 60901
Contact: Jane N. Winter    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Jane N. Winter         
North Shore Hematology Oncology Recruiting
Libertyville, Illinois, United States, 60048
Contact: Jane N. Winter    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Jane N. Winter         
Carle Physician Group-Mattoon/Charleston Recruiting
Mattoon, Illinois, United States, 61938
Contact: Maria T. Grosse-Perdekamp    800-446-5532      
Principal Investigator: Maria T. Grosse-Perdekamp         
Good Samaritan Regional Health Center Recruiting
Mount Vernon, Illinois, United States, 62864
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
Illinois Cancer Specialists-Niles Recruiting
Niles, Illinois, United States, 60714
Contact: Jane N. Winter    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Jane N. Winter         
Swedish American Hospital Withdrawn
Rockford, Illinois, United States, 61104
SwedishAmerican Regional Cancer Center/ACT Recruiting
Rockford, Illinois, United States, 61107
Contact: Harvey E. Einhorn    779-696-9400    cancercare@swedishamerican.org   
Principal Investigator: Harvey E. Einhorn         
Hematology Oncology Associates of Illinois - Skokie Recruiting
Skokie, Illinois, United States, 60076
Contact: Jane N. Winter    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Jane N. Winter         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Maria T. Grosse-Perdekamp    800-446-5532      
Principal Investigator: Maria T. Grosse-Perdekamp         
The Carle Foundation Hospital Recruiting
Urbana, Illinois, United States, 61801
Contact: Maria T. Grosse-Perdekamp    800-446-5532      
Principal Investigator: Maria T. Grosse-Perdekamp         
United States, Indiana
Saint Francis Hospital and Health Centers Withdrawn
Beech Grove, Indiana, United States, 46107
Franciscan Saint Francis Health-Indianapolis Withdrawn
Indianapolis, Indiana, United States, 46237
IU Health Arnett Cancer Care Active, not recruiting
Lafayette, Indiana, United States, 47904
Franciscan Saint Anthony Health-Michigan City Recruiting
Michigan City, Indiana, United States, 46360
Contact: Maria T. Grosse-Perdekamp    800-446-5532      
Principal Investigator: Maria T. Grosse-Perdekamp         
Woodland Cancer Care Center Recruiting
Michigan City, Indiana, United States, 46360
Contact: Maria T. Grosse-Perdekamp    800-446-5532      
Principal Investigator: Maria T. Grosse-Perdekamp         
Reid Hospital and Health Care Services Recruiting
Richmond, Indiana, United States, 47374
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
United States, Iowa
Mary Greeley Medical Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Hematology Oncology Associates-Quad Cities Active, not recruiting
Bettendorf, Iowa, United States, 52722
McFarland Clinic PC-Boone Recruiting
Boone, Iowa, United States, 50036
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Cedar Rapids Oncology Association Terminated
Cedar Rapids, Iowa, United States, 52403
Mercy Hospital Recruiting
Cedar Rapids, Iowa, United States, 52403
Contact: Deborah W. Wilbur    319-363-2690      
Principal Investigator: Deborah W. Wilbur         
Oncology Associates at Mercy Medical Center Recruiting
Cedar Rapids, Iowa, United States, 52403
Contact: Deborah W. Wilbur    319-363-2690      
Principal Investigator: Deborah W. Wilbur         
McFarland Clinic PC-Trinity Cancer Center Recruiting
Fort Dodge, Iowa, United States, 50501
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-Jefferson Recruiting
Jefferson, Iowa, United States, 50129
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-Marshalltown Recruiting
Marshalltown, Iowa, United States, 50158
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Mercy Medical Center-Sioux City Terminated
Sioux City, Iowa, United States, 51104
Saint Luke's Regional Medical Center Terminated
Sioux City, Iowa, United States, 51104
Siouxland Hematology Oncology Associates Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
United States, Kansas
Lawrence Memorial Hospital Recruiting
Lawrence, Kansas, United States, 66044
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Menorah Medical Center Recruiting
Overland Park, Kansas, United States, 66209
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Luke's South Hospital Recruiting
Overland Park, Kansas, United States, 66213
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Kansas City CCOP Terminated
Prairie Village, Kansas, United States, 66208
Wesley Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
United States, Kentucky
Oncology Hematology Care Inc-Crestview Recruiting
Crestview Hills, Kentucky, United States, 41017
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
United States, Louisiana
Ochsner Health Center-Summa Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
Ochsner Baptist Medical Center Recruiting
New Orleans, Louisiana, United States, 70115
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
Ochsner Medical Center Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
United States, Maine
Harold Alfond Center for Cancer Care Active, not recruiting
Augusta, Maine, United States, 04330
Eastern Maine Medical Center Recruiting
Bangor, Maine, United States, 04401
Contact: Thomas H. Openshaw    207-973-4274      
Principal Investigator: Thomas H. Openshaw         
Penobscot Bay Medical Center Active, not recruiting
Rockport, Maine, United States, 04856
United States, Maryland
Franklin Square Hospital Center Recruiting
Baltimore, Maryland, United States, 21237
Contact: Suman B. Rao    443-777-7364      
Principal Investigator: Suman B. Rao         
Union Hospital of Cecil County Active, not recruiting
Elkton MD, Maryland, United States, 21921
Holy Cross Hospital Recruiting
Silver Spring, Maryland, United States, 20910
Contact: Frederick D. Min    310-754-7552      
Principal Investigator: Frederick D. Min         
United States, Massachusetts
Tufts Medical Center Recruiting
Boston, Massachusetts, United States, 02111
Contact: Andrew M. Evens    617-636-5000    ContactUsCancerCenter@TuftsMedicalCenter.org   
Principal Investigator: Andrew M. Evens         
Simonds-Sinon Regional Cancer Center Recruiting
Fitchburg, Massachusetts, United States, 01420
Contact: Alan G. Rosmarin    508-856-3216    cancer.research@umassmed.edu   
Principal Investigator: Alan G. Rosmarin         
Baystate Medical Center Recruiting
Springfield, Massachusetts, United States, 01199
Contact: Syed S. Ali    413-794-3565    tamara.wrenn@baystatehealth.org   
Principal Investigator: Syed S. Ali         
University of Massachusetts Medical School Recruiting
Worcester, Massachusetts, United States, 01655
Contact: Alan G. Rosmarin    508-856-3216    cancer.research@umassmed.edu   
Principal Investigator: Alan G. Rosmarin         
United States, Michigan
Michigan Cancer Research Consortium Community Clinical Oncology Program Terminated
Ann Arbor, Michigan, United States, 48106
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Bronson Battle Creek Recruiting
Battle Creek, Michigan, United States, 49017
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Spectrum Health Big Rapids Hospital Terminated
Big Rapids, Michigan, United States, 49307
Oakwood Hospital and Medical Center Recruiting
Dearborn, Michigan, United States, 48124
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Wayne State University/Karmanos Cancer Institute Recruiting
Detroit, Michigan, United States, 48201
Contact: Radhakrishnan Ramchandren    313-576-9363      
Principal Investigator: Radhakrishnan Ramchandren         
Green Bay Oncology - Escanaba Recruiting
Escanaba, Michigan, United States, 49431
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Weisberg Cancer Treatment Center Recruiting
Farmington Hills, Michigan, United States, 48334
Contact: Radhakrishnan Ramchandren    313-576-9363      
Principal Investigator: Radhakrishnan Ramchandren         
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Genesys Regional Medical Center-West Flint Campus Withdrawn
Flint, Michigan, United States, 48532
Hurley Medical Center Recruiting
Flint, Michigan, United States, 48502
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Genesys Regional Medical Center Terminated
Grand Blanc, Michigan, United States, 48439
Grand Rapids Clinical Oncology Program Terminated
Grand Rapids, Michigan, United States, 49503
Mercy Health Saint Mary's Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Green Bay Oncology - Iron Mountain Recruiting
Iron Mountain, Michigan, United States, 49801
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Allegiance Health Recruiting
Jackson, Michigan, United States, 49201
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Borgess Medical Center Recruiting
Kalamazoo, Michigan, United States, 49001
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
Bronson Methodist Hospital Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
Sparrow Hospital Recruiting
Lansing, Michigan, United States, 48912
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Saint Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Mercy Health Mercy Campus Recruiting
Muskegon, Michigan, United States, 49444
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Lakeland Community Hospital Recruiting
Niles, Michigan, United States, 49120
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Saint Joseph Mercy Port Huron Recruiting
Port Huron, Michigan, United States, 48060
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Spectrum Health Reed City Hospital Recruiting
Reed City, Michigan, United States, 49677
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Marie Yeager Cancer Center Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Lakeland Hospital Recruiting
St. Joseph, Michigan, United States, 49085
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Gilbert D. Padula    616-685-5225    connie.szczepanek@grcop.org   
Principal Investigator: Gilbert D. Padula         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
United States, Minnesota
Sanford Clinic North-Bemidgi Active, not recruiting
Bemidji, Minnesota, United States, 56601
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Miller-Dwan Hospital Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Essentia Health Saint Mary's Medical Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Essentia Health Cancer Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Hutchinson Area Health Care Recruiting
Hutchinson, Minnesota, United States, 55350
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Health Partners Inc Recruiting
Minneapolis, Minnesota, United States, 55454
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
New Ulm Medical Center Active, not recruiting
New Ulm, Minnesota, United States, 56073
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: David J. Inwards    507-538-7623      
Principal Investigator: David J. Inwards         
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Metro-Minnesota CCOP Terminated
Saint Louis Park, Minnesota, United States, 55416
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Lakeview Hospital Active, not recruiting
Stillwater, Minnesota, United States, 55082
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Minnesota Oncology and Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United States, Missouri
Parkland Health Center-Bonne Terre Recruiting
Bonne Terre, Missouri, United States, 63628
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Saint Francis Medical Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Southeast Cancer Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Saint Luke's Hospital Withdrawn
Chesterfield, Missouri, United States, 63017
University of Missouri - Ellis Fischel Recruiting
Columbia, Missouri, United States, 65212
Contact: Donald C. Doll    573-882-7440      
Principal Investigator: Donald C. Doll         
Centerpoint Medical Center LLC Recruiting
Independence, Missouri, United States, 64057
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Capital Region Medical Center-Goldschmidt Cancer Center Recruiting
Jefferson City, Missouri, United States, 65109
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Freeman Health System Active, not recruiting
Joplin, Missouri, United States, 64804
Heartland Hematology and Oncology Associates Incorporated Recruiting
Kansas City, Missouri, United States, 64118
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Research Medical Center Recruiting
Kansas City, Missouri, United States, 64132
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Luke's Hospital of Kansas City Recruiting
Kansas City, Missouri, United States, 64111
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Luke's East - Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64086
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Liberty Radiation Oncology Center Recruiting
Liberty, Missouri, United States, 64068
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Phelps County Regional Medical Center Active, not recruiting
Rolla, Missouri, United States, 65401
Saint John's Clinic-Rolla-Cancer and Hematology Active, not recruiting
Rolla, Missouri, United States, 65401
Heartland Regional Medical Center Recruiting
Saint Joseph, Missouri, United States, 64506
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Comprehensive Cancer Care PC Terminated
Saint Louis, Missouri, United States, 63141
Missouri Baptist Medical Center Recruiting
Saint Louis, Missouri, United States, 63131
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Saint John's Mercy Medical Center Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
Saint Louis Cancer and Breast Institute-South City Recruiting
Saint Louis, Missouri, United States, 63109
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
Saint Louis-Cape Girardeau CCOP Withdrawn
Saint Louis, Missouri, United States, 63141
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Nancy L. Bartlett    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Nancy L. Bartlett         
CoxHealth South Hospital Recruiting
Springfield, Missouri, United States, 65807
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
Mercy Hospital Springfield Recruiting
Springfield, Missouri, United States, 65804
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Terminated
Springfield, Missouri, United States, 65804
Missouri Baptist Sullivan Hospital Recruiting
Sullivan, Missouri, United States, 63080
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Missouri Baptist Outpatient Center-Sunset Hills Recruiting
Sunset Hills, Missouri, United States, 63127
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
United States, Montana
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59107
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Frontier Cancer Center and Blood Institute-Billings Terminated
Billings, Montana, United States, 59102
Montana Cancer Consortium CCOP Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Vincent Healthcare Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Cancer Center Withdrawn
Bozeman, Montana, United States, 59715
Saint James Community Hospital and Cancer Treatment Center Recruiting
Butte, Montana, United States, 59701
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Great Falls Clinic Terminated
Great Falls, Montana, United States, 59405
Northern Montana Hospital Terminated
Havre, Montana, United States, 59501
Saint Peter's Community Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Glacier Oncology PLLC Terminated
Kalispell, Montana, United States, 59901
Kalispell Medical Oncology Terminated
Kalispell, Montana, United States, 59901
Community Medical Hospital Recruiting
Missoula, Montana, United States, 59801
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Montana Cancer Specialists Terminated
Missoula, Montana, United States, 59802
Saint Patrick Hospital - Community Hospital Recruiting
Missoula, Montana, United States, 59802
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, New Hampshire
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Frederick Lansigan    800-639-6918    cancer.research.nurse@dartmouth.edu   
Principal Investigator: Frederick Lansigan         
Norris Cotton Cancer Center Nashua Recruiting
Nashua, New Hampshire, United States, 03063
Contact: Frederick Lansigan    800-639-6918    cancer.research.nurse@dartmouth.edu   
Principal Investigator: Frederick Lansigan         
United States, New Jersey
Cooper Hospital University Medical Center Active, not recruiting
Camden, New Jersey, United States, 08103
Veterans Adminstration New Jersey Health Care System Recruiting
East Orange, New Jersey, United States, 07018-1095
Contact: Victor T. Chang    800-475-2336    patricia.goyer@med.va.gov   
Principal Investigator: Victor T. Chang         
United States, New York
Hematology Oncology Associates of Central New York-Auburn Active, not recruiting
Auburn, New York, United States, 13021
Albert Einstein College of Medicine Recruiting
Bronx, New York, United States, 10461
Contact: Ramakrishna Battini    718-904-2730    aecc@aecom.yu.edu   
Principal Investigator: Ramakrishna Battini         
Montefiore Medical Center - Moses Campus Recruiting
Bronx, New York, United States, 10467-2490
Contact: Ramakrishna Battini    718-904-2730    aecc@aecom.yu.edu   
Principal Investigator: Ramakrishna Battini         
Hematology Oncology Associates of Central New York-East Syracuse Active, not recruiting
East Syracuse, New York, United States, 13057
Glens Falls Hospital Recruiting
Glens Falls, New York, United States, 12801
Contact: John P. Stoutenburg    518-926-6700      
Principal Investigator: John P. Stoutenburg         
Hematology Oncology Associates of Central New York-Liverpool Terminated
Liverpool, New York, United States, 13088
Orange Regional Medical Center Active, not recruiting
Middletown, New York, United States, 10940
Mount Sinai Medical Center Recruiting
New York, New York, United States, 10029
Contact: Samir S. Parekh    212-824-7320    jenny.figueroa@mssm.edu   
Principal Investigator: Samir S. Parekh         
Weill Medical College of Cornell University Recruiting
New York, New York, United States, 10065
Contact: Peter Martin    212-746-1848      
Principal Investigator: Peter Martin         
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Jonathan W. Friedberg    585-275-5830      
Principal Investigator: Jonathan W. Friedberg         
Hematology Oncology Associates of Central New York-Rome Terminated
Rome, New York, United States, 13440
Hematology Oncology Associates of Central New York-Onondaga Hill Active, not recruiting
Syracuse, New York, United States, 13215
United States, North Carolina
Southeastern Medical Oncology Center-Clinton Recruiting
Clinton, North Carolina, United States, 28328
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Southeastern Medical Oncology Center-Goldsboro Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Wayne Memorial Hospital Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Hendersonville Hematology and Oncology at Pardee Recruiting
Hendersonville, North Carolina, United States, 28739
Contact: James E. Radford    828-696-4716      
Principal Investigator: James E. Radford         
Margaret R Pardee Memorial Hospital Recruiting
Hendersonville, North Carolina, United States, 28791
Contact: James E. Radford    828-696-4716      
Principal Investigator: James E. Radford         
Park Ridge Hospital Breast Health Center Active, not recruiting
Hendersonville, North Carolina, United States, 28792
Southeastern Medical Oncology Center-Jacksonville Recruiting
Jacksonville, North Carolina, United States, 28546
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Kinston Medical Specialists PA Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson    252-559-2200      
Principal Investigator: Peter R. Watson         
Iredell Memorial Hospital Recruiting
Statesville, North Carolina, United States, 28677
Contact: Ruby A. Grimm    704-873-5661      
Principal Investigator: Ruby A. Grimm         
Southeastern Medical Oncology Center-Wilson Recruiting
Wilson, North Carolina, United States, 27893
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Wake Forest University Health Sciences Recruiting
Winston-Salem, North Carolina, United States, 27157
Contact: Zanetta S. Lamar    336-713-6771      
Principal Investigator: Zanetta S. Lamar         
United States, North Dakota
Sanford Clinic North-Fargo Active, not recruiting
Fargo, North Dakota, United States, 58122
Sanford Medical Center-Fargo Active, not recruiting
Fargo, North Dakota, United States, 58122
Roger Maris Cancer Center Active, not recruiting
Fargo, North Dakota, United States, 58122
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center Recruiting
Akron, Ohio, United States, 44304
Contact: Jennifer E. Payne    330-375-6101      
Principal Investigator: Jennifer E. Payne         
Summa Barberton Hospital Recruiting
Barberton, Ohio, United States, 44203
Contact: Jennifer E. Payne    330-375-6101      
Principal Investigator: Jennifer E. Payne         
Cleveland Clinic Cancer Center Beachwood Recruiting
Beachwood, Ohio, United States, 44122
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Oncology and Hematology Care Inc-Taft Recruiting
Cincinnati, Ohio, United States, 45219
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Oncology Hematology Care Inc - Anderson Recruiting
Cincinnati, Ohio, United States, 45230
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Oncology Hematology Care Inc - Kenwood Recruiting
Cincinnati, Ohio, United States, 45236
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Oncology Hematology Care Inc-Blue Ash Recruiting
Cincinnati, Ohio, United States, 45242
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Oncology Hematology Care Inc-Mercy West Recruiting
Cincinnati, Ohio, United States, 45211
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
University of Cincinnati Recruiting
Cincinnati, Ohio, United States, 45267
Contact: Stephen C. Medlin    513-558-4553    uchealthnews@uc.edu   
Principal Investigator: Stephen C. Medlin         
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
Cleveland Clinic Cancer Center/Fairview Hospital Recruiting
Cleveland, Ohio, United States, 44111
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
MetroHealth Medical Center Recruiting
Cleveland, Ohio, United States, 44109
Contact: Bruce J. Averbook    216-778-8526    kbauchens@metrohealth.org   
Principal Investigator: Bruce J. Averbook         
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Recruiting
Columbus, Ohio, United States, 43210
Contact: Kristie A. Blum    800-293-5066    Jamesline@osumc.edu   
Principal Investigator: Kristie A. Blum         
Miami Valley Hospital Recruiting
Dayton, Ohio, United States, 45409
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Good Samaritan Hospital - Dayton Recruiting
Dayton, Ohio, United States, 45406
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Grandview Hospital Active, not recruiting
Dayton, Ohio, United States, 45405
Dayton CCOP Terminated
Dayton, Ohio, United States, 45420
Samaritan North Health Center Recruiting
Dayton, Ohio, United States, 45415
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Mercy Cancer Center-Elyria Recruiting
Elyria, Ohio, United States, 44035
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
Oncology Hematology Care Inc-Healthplex Recruiting
Fairfield, Ohio, United States, 45014
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Blanchard Valley Hospital Recruiting
Findlay, Ohio, United States, 45840
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Atrium Medical Center-Middletown Regional Hospital Recruiting
Franklin, Ohio, United States, 45005-1066
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Wayne Hospital Recruiting
Greenville, Ohio, United States, 45331
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Cleveland Clinic Cancer Center Independence Recruiting
Independence, Ohio, United States, 44131
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Kettering Medical Center Recruiting
Kettering, Ohio, United States, 45429
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
Cleveland Clinic Cancer Center Mansfield Recruiting
Mansfield, Ohio, United States, 44906
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Hillcrest Hospital Cancer Center Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Lake University Ireland Cancer Center Recruiting
Mentor, Ohio, United States, 44060
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
University Hospitals Parma Medical Center Withdrawn
Parma, Ohio, United States, 44129
North Coast Cancer Care Recruiting
Sandusky, Ohio, United States, 44870
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Cleveland Clinic Cancer Center Strongsville Recruiting
Strongsville, Ohio, United States, 44136
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Upper Valley Medical Center Recruiting
Troy, Ohio, United States, 45373
Contact: Howard M. Gross    937-775-1350      
Principal Investigator: Howard M. Gross         
South Pointe Hospital Recruiting
Warrensville Heights, Ohio, United States, 44122
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
University Pointe Recruiting
West Chester, Ohio, United States, 45069
Contact: Stephen C. Medlin    513-558-4553    uchealthnews@uc.edu   
Principal Investigator: Stephen C. Medlin         
UH-Seidman Cancer Center at Saint John Medical Center Recruiting
Westlake, Ohio, United States, 44145
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
Cleveland Clinic Wooster Specialty Center Recruiting
Wooster, Ohio, United States, 44691
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Greene Memorial Hospital Terminated
Xenia, Ohio, United States, 45385
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Mohamad Cherry    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Mohamad Cherry         
Tulsa Cancer Institute Recruiting
Tulsa, Oklahoma, United States, 74146
Contact: Mohamad Cherry    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Mohamad Cherry         
United States, Oregon
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Milwaukie Hospital Terminated
Milwaukie, Oregon, United States, 97222
Providence Newberg Medical Center Recruiting
Newberg, Oregon, United States, 97132
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Willamette Falls Medical Center Recruiting
Oregon City, Oregon, United States, 97045
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Western Oncology Research Consortium Terminated
Portland, Oregon, United States, 97213
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
United States, Pennsylvania
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Geisinger Medical Center-Cancer Center Hazleton Recruiting
Hazleton, Pennsylvania, United States, 18201
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Geisinger Medical Oncology at Evangelical Community Hospital Recruiting
Lewisburg, Pennsylvania, United States, 17837
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Lewistown Hospital Recruiting
Lewistown, Pennsylvania, United States, 17044
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Fox Chase Cancer Center Recruiting
Philadelphia, Pennsylvania, United States, 19111
Contact: Michael M. Millenson    215-728-4790      
Principal Investigator: Michael M. Millenson         
Pottstown Memorial Medical Center Recruiting
Pottstown, Pennsylvania, United States, 19464
Contact: Wei (. Song    610-327-7544      
Principal Investigator: Wei (. Song         
Geisinger Medical Oncology-Pottsville Recruiting
Pottsville, Pennsylvania, United States, 17901
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Geisinger Medical Group Recruiting
State College, Pennsylvania, United States, 16801
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Mount Nittany Medical Center Recruiting
State College, Pennsylvania, United States, 16803
Contact: John P. Ford    814-231-7813    smoyer@mountnittany.org   
Principal Investigator: John P. Ford         
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Terrence P. Cescon    610-988-9323      
Principal Investigator: Terrence P. Cescon         
Geisinger Wyoming Valley Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
United States, South Carolina
AnMed Health Cancer Center Active, not recruiting
Anderson, South Carolina, United States, 29621
Saint Francis Hospital Active, not recruiting
Greenville, South Carolina, United States, 29601
Gibbs Cancer Center-Pelham Recruiting
Greer, South Carolina, United States, 29651
Contact: Charles E. Bowers    800-486-5941      
Principal Investigator: Charles E. Bowers         
Spartanburg Regional Medical Center Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: Charles E. Bowers    800-486-5941      
Principal Investigator: Charles E. Bowers         
Upstate Carolina CCOP Terminated
Spartanburg, South Carolina, United States, 29303
United States, Tennessee
Wellmont Medical Associates Oncology and Hematology-Bristol Active, not recruiting
Bristol, Tennessee, United States, 37620
Wellmont Bristol Regional Medical Center Active, not recruiting
Bristol, Tennessee, United States, 37620
Wellmont Holston Valley Hospital and Medical Center Recruiting
Kingsport, Tennessee, United States, 37660
Contact: Asheesh Shipstone    423-578-8538      
Principal Investigator: Asheesh Shipstone         
Wellmont Medical Associates Oncology and Hematology-Kingsport Recruiting
Kingsport, Tennessee, United States, 37660
Contact: Asheesh Shipstone    423-578-8538      
Principal Investigator: Asheesh Shipstone         
Vanderbilt-Ingram Cancer Center Active, not recruiting
Nashville, Tennessee, United States, 37232
United States, Texas
University of Texas Southwestern Medical Center Active, not recruiting
Dallas, Texas, United States, 75390
Parkland Memorial Hospital Active, not recruiting
Dallas, Texas, United States, 75235
United States, Virginia
University of Virginia Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Michael E. Williams    434-243-6143      
Principal Investigator: Michael E. Williams         
Memorial Hospital Of Martinsville Recruiting
Martinsville, Virginia, United States, 24115
Contact: Sreedhar Katragadda    276-666-7827      
Principal Investigator: Sreedhar Katragadda         
Southwest VA Regional Cancer Center Active, not recruiting
Norton, Virginia, United States, 24273
United States, Washington
Kadlec Clinic Hematology and Oncology Recruiting
Kennewick, Washington, United States, 99336
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
EvergreenHealth Medical Center Recruiting
Kirkland, Washington, United States, 98033
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
Seattle Cancer Care Alliance at EvergreenHealth Recruiting
Kirkland, Washington, United States, 98034
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
Saint John Medical Center Recruiting
Longview, Washington, United States, 98632
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Skagit Valley Hospital Recruiting
Mount Vernon, Washington, United States, 98274
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
Skagit Valley Hospital Regional Cancer Care Center Recruiting
Mount Vernon, Washington, United States, 98273
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
Olympic Medical Center Recruiting
Port Angeles, Washington, United States, 98362
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Recruiting
Seattle, Washington, United States, 98109
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
Seattle Cancer Care Alliance Recruiting
Seattle, Washington, United States, 98109
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
University of Washington Medical Center Recruiting
Seattle, Washington, United States, 98195
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
Olympic Medical Cancer Care Center Recruiting
Sequim, Washington, United States, 98384
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
Cancer Care Northwest - Spokane South Recruiting
Spokane, Washington, United States, 99202
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
Cancer Care Northwest-North Spokane Recruiting
Spokane, Washington, United States, 99218
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
Cancer Care Northwest-Valley Recruiting
Spokane, Washington, United States, 99216
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Compass Oncology Vancouver Active, not recruiting
Vancouver, Washington, United States, 98684
Wenatchee Valley Hospital and Clinics Recruiting
Wenatchee, Washington, United States, 98801
Contact: Brian G. Till    800-422-6237      
Principal Investigator: Brian G. Till         
United States, West Virginia
West Virginia University Healthcare Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Abraham S. Kanate    304-293-2745    sfilburn@hsc.wvu.edu   
Principal Investigator: Abraham S. Kanate         
United States, Wisconsin
Langlade Hospital and Cancer Center Recruiting
Antigo, Wisconsin, United States, 54409
Contact: Hamied R. Rezazadeh    877-405-6866      
Principal Investigator: Hamied R. Rezazadeh         
Marshfield Clinic Cancer Center at Sacred Heart Active, not recruiting
Eau Claire, Wisconsin, United States, 54701
Sacred Heart Hospital Active, not recruiting
Eau Claire, Wisconsin, United States, 54701
Agnesian Cancer Center Recruiting
Fond Du Lac, Wisconsin, United States, 54935
Contact: Michael W. Jones    800-494-2927      
Principal Investigator: Michael W. Jones         
Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Green Bay Oncology Limited at Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Green Bay Oncology at Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301-3526
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
UW Cancer Center Johnson Creek Active, not recruiting
Johnson Creek, Wisconsin, United States, 53038
Gundersen Lutheran Medical Center Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Kurt Oettel    608-775-2385    cancerctr@gundluth.org   
Principal Investigator: Kurt Oettel         
University of Wisconsin Hospital and Clinics Active, not recruiting
Madison, Wisconsin, United States, 53792
Holy Family Memorial Hospital Recruiting
Manitowoc, Wisconsin, United States, 54221
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Bay Area Medical Center Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Marshfield Clinic Active, not recruiting
Marshfield, Wisconsin, United States, 54449
Saint Joseph's Hospital Active, not recruiting
Marshfield, Wisconsin, United States, 54449
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Timothy S. Fenske    414-805-4380      
Principal Investigator: Timothy S. Fenske         
Marshfield Clinic-Minocqua Center Active, not recruiting
Minocqua, Wisconsin, United States, 54548
D N Greenwald Center Recruiting
Mukwonago, Wisconsin, United States, 53149
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Cancer Center of Western Wisconsin Recruiting
New Richmond, Wisconsin, United States, 54017
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Oconomowoc Memorial Hospital-ProHealth Care Inc Recruiting
Oconomowoc, Wisconsin, United States, 53066-3896
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Green Bay Oncology - Oconto Falls Recruiting
Oconto Falls, Wisconsin, United States, 54154
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Marshfield Clinic at James Beck Cancer Center Active, not recruiting
Rhinelander, Wisconsin, United States, 54501
Saint Mary's Hospital Active, not recruiting
Rhinelander, Wisconsin, United States, 54501
Marshfield Clinic-Rice Lake Center Active, not recruiting
Rice Lake, Wisconsin, United States, 54868
Saint Nicholas Hospital Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Marshfield Clinic Cancer Care at Saint Michael's Hospital Active, not recruiting
Stevens Point, Wisconsin, United States, 54481
Saint Michael's Hospital Active, not recruiting
Stevens Point, Wisconsin, United States, 54481
Green Bay Oncology - Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Waukesha Memorial Hospital - ProHealth Care Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Aspirus Regional Cancer Center Recruiting
Wausau, Wisconsin, United States, 54401
Contact: Hamied R. Rezazadeh    877-405-6866      
Principal Investigator: Hamied R. Rezazadeh         
Marshfield Clinic-Wausau Center Active, not recruiting
Wausau, Wisconsin, United States, 54401
Saint Clare's Hospital Active, not recruiting
Weston, Wisconsin, United States, 54476
Marshfield Clinic - Weston Center Active, not recruiting
Weston, Wisconsin, United States, 54476
Diagnostic and Treatment Center Active, not recruiting
Weston, Wisconsin, United States, 54476
Marshfield Clinic - Wisconsin Rapids Center Active, not recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
United States, Wyoming
Rocky Mountain Oncology Terminated
Casper, Wyoming, United States, 82609
Big Horn Basin Cancer Center Recruiting
Cody, Wyoming, United States, 82414
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Billings Clinic-Cody Recruiting
Cody, Wyoming, United States, 82414
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Welch Cancer Center Recruiting
Sheridan, Wyoming, United States, 82801
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Canada, New Brunswick
The Moncton Hospital Recruiting
Moncton, New Brunswick, Canada, E1C 6Z8
Contact: Nizar N. Abdel-Samad    506-857-5267      
Principal Investigator: Nizar N. Abdel-Samad         
Canada, Saskatchewan
Allan Blair Cancer Centre Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Haji I. Chalchal    306-766-2213      
Principal Investigator: Haji I. Chalchal         
Sponsors and Collaborators
Eastern Cooperative Oncology Group
Investigators
Principal Investigator: Mitchell R. Smith, MD, PhD Fox Chase Cancer Center
  More Information

Additional Information:
No publications provided

Responsible Party: Eastern Cooperative Oncology Group
ClinicalTrials.gov Identifier: NCT01415752     History of Changes
Other Study ID Numbers: E1411, ECOG-E1411, NCI-2011-02980, CDR0000707057
Study First Received: August 11, 2011
Last Updated: March 13, 2015
Health Authority: United States: Food and Drug Administration

Keywords provided by Eastern Cooperative Oncology Group:
neurotoxicity
therapy-related toxicity
contiguous stage II mantle cell lymphoma
noncontiguous stage II mantle cell lymphoma
stage I mantle cell lymphoma
stage III mantle cell lymphoma
stage IV mantle cell lymphoma

Additional relevant MeSH terms:
Lymphoma, Mantle-Cell
Immune System Diseases
Immunoproliferative Disorders
Lymphatic Diseases
Lymphoma
Lymphoma, Non-Hodgkin
Lymphoproliferative Disorders
Neoplasms
Neoplasms by Histologic Type
Bendamustine
Bortezomib
Lenalidomide
Nitrogen Mustard Compounds
Rituximab
Alkylating Agents
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Antineoplastic Agents
Antineoplastic Agents, Alkylating
Antirheumatic Agents
Growth Inhibitors
Growth Substances
Immunologic Factors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses

ClinicalTrials.gov processed this record on March 31, 2015