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Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer

This study is currently recruiting participants.
See Contacts and Locations
Verified May 2017 by Gynecologic Oncology Group
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Gynecologic Oncology Group
ClinicalTrials.gov Identifier:
NCT01414608
First received: August 10, 2011
Last updated: May 2, 2017
Last verified: May 2017
  Purpose
This randomized phase III trial studies how well giving cisplatin and radiation therapy together with or without carboplatin and paclitaxel works in treating patients with cervical cancer has spread from where it started to nearby tissue or lymph nodes. Drugs used in chemotherapy, such as cisplatin, carboplatin, and paclitaxel, work in different ways to stop the growth of [cancer/tumor] cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. External radiation therapy uses high-energy x rays to kill tumor cells. Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. It is not yet known whether giving cisplatin and external and internal radiation therapy together with carboplatin and paclitaxel kills more tumor cells.

Condition Intervention Phase
Cervical Adenocarcinoma Cervical Adenosquamous Carcinoma Cervical Squamous Cell Carcinoma, Not Otherwise Specified Chemotherapeutic Agent Toxicity Cognitive Side Effects of Cancer Therapy Psychological Impact of Cancer Radiation Toxicity Sexual Dysfunction and Infertility Stage IB Cervical Cancer Stage IIA Cervical Cancer Stage IIB Cervical Cancer Stage IIIB Cervical Cancer Stage IVA Cervical Cancer Drug: Carboplatin Drug: Cisplatin Radiation: External Beam Radiation Therapy Radiation: Internal Radiation Therapy Drug: Paclitaxel Other: Quality-of-Life Assessment Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: No masking
Primary Purpose: Treatment
Official Title: A Phase III Trial of Adjuvant Chemotherapy Following Chemoradiation as Primary Treatment for Locally Advanced Cervical Cancer Compared to Chemoradiation Alone: The OUTBACK Trial

Resource links provided by NLM:


Further study details as provided by Gynecologic Oncology Group:

Primary Outcome Measures:
  • Overall survival rate [ Time Frame: From randomization to death from any cause, assessed at 5 years ]
    Described with Kaplan-Meier curves and unadjusted logrank tests.


Secondary Outcome Measures:
  • Patterns of disease recurrence [ Time Frame: Up to 5 years ]
  • Progression-free survival rate [ Time Frame: From randomization to the time of disease progression as determined by the investigator or death from any cause, assessed at 3 years ]
  • Progression-free survival rate [ Time Frame: From randomization to the time of disease progression as determined by the investigator or death from any cause, assessed at 5 years ]
  • Quality of life including psychosexual health [ Time Frame: Up to 36 months ]
  • Radiation protocol compliance [ Time Frame: Up to 5 years ]
  • Rate of acute and long-term toxicities [ Time Frame: Up to 5 years ]

Estimated Enrollment: 900
Study Start Date: January 2012
Estimated Primary Completion Date: July 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I (cisplatin, radiation therapy, brachytherapy)
Patients receive cisplatin IV over 60-90 minutes on days 1, 8, 15, 22, and 29. Patients also undergo external-beam radiation therapy once daily, 5 days a week, for approximately 5 weeks. Patients then undergo high-dose rate, pulsed-dose rate, or low-dose rate intracavitary brachytherapy.
Drug: Cisplatin
Given IV
Other Names:
  • Abiplatin
  • Blastolem
  • Briplatin
  • CDDP
  • Cis-diammine-dichloroplatinum
  • Cis-diamminedichloridoplatinum
  • Cis-diamminedichloro Platinum (II)
  • Cis-diamminedichloroplatinum
  • Cis-dichloroammine Platinum (II)
  • Cis-platinous Diamine Dichloride
  • Cis-platinum
  • Cis-platinum II
  • Cis-platinum II Diamine Dichloride
  • Cismaplat
  • Cisplatina
  • Cisplatinum
  • Cisplatyl
  • Citoplatino
  • Citosin
  • Cysplatyna
  • DDP
  • Lederplatin
  • Metaplatin
  • Neoplatin
  • Peyrone's Chloride
  • Peyrone's Salt
  • Placis
  • Plastistil
  • Platamine
  • Platiblastin
  • Platiblastin-S
  • Platinex
  • Platinol
  • Platinol- AQ
  • Platinol-AQ
  • Platinol-AQ VHA Plus
  • Platinoxan
  • Platinum
  • Platinum Diamminodichloride
  • Platiran
  • Platistin
  • Platosin
Radiation: External Beam Radiation Therapy
Undergo external beam radiation therapy
Other Names:
  • Definitive Radiation Therapy
  • EBRT
  • External Beam Radiotherapy
  • External Beam RT
  • external radiation
  • External Radiation Therapy
  • external-beam radiation
Radiation: Internal Radiation Therapy
Undergo brachytherapy
Other Names:
  • BRACHYTHERAPY
  • Internal Radiation
  • Internal Radiation Brachytherapy
  • Radiation Brachytherapy
Other: Quality-of-Life Assessment
Ancillary studies
Other Name: Quality of Life Assessment
Experimental: Arm II (cisplatin, radiation therapy, brachytherapy, chemo)
Patients receive cisplatin and undergo external-beam radiation and brachytherapy as in arm I. Beginning 4 weeks later, patients also receive adjuvant chemotherapy comprising paclitaxel IV over 3 hours and carboplatin IV over 1 hour on day 1. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.
Drug: Carboplatin
Given IV
Other Names:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatinum
  • Paraplat
  • Paraplatin
  • Paraplatin AQ
  • Paraplatine
  • Platinwas
  • Ribocarbo
Drug: Cisplatin
Given IV
Other Names:
  • Abiplatin
  • Blastolem
  • Briplatin
  • CDDP
  • Cis-diammine-dichloroplatinum
  • Cis-diamminedichloridoplatinum
  • Cis-diamminedichloro Platinum (II)
  • Cis-diamminedichloroplatinum
  • Cis-dichloroammine Platinum (II)
  • Cis-platinous Diamine Dichloride
  • Cis-platinum
  • Cis-platinum II
  • Cis-platinum II Diamine Dichloride
  • Cismaplat
  • Cisplatina
  • Cisplatinum
  • Cisplatyl
  • Citoplatino
  • Citosin
  • Cysplatyna
  • DDP
  • Lederplatin
  • Metaplatin
  • Neoplatin
  • Peyrone's Chloride
  • Peyrone's Salt
  • Placis
  • Plastistil
  • Platamine
  • Platiblastin
  • Platiblastin-S
  • Platinex
  • Platinol
  • Platinol- AQ
  • Platinol-AQ
  • Platinol-AQ VHA Plus
  • Platinoxan
  • Platinum
  • Platinum Diamminodichloride
  • Platiran
  • Platistin
  • Platosin
Radiation: External Beam Radiation Therapy
Undergo external beam radiation therapy
Other Names:
  • Definitive Radiation Therapy
  • EBRT
  • External Beam Radiotherapy
  • External Beam RT
  • external radiation
  • External Radiation Therapy
  • external-beam radiation
Radiation: Internal Radiation Therapy
Undergo brachytherapy
Other Names:
  • BRACHYTHERAPY
  • Internal Radiation
  • Internal Radiation Brachytherapy
  • Radiation Brachytherapy
Drug: Paclitaxel
Given IV
Other Names:
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol
  • Taxol Konzentrat
Other: Quality-of-Life Assessment
Ancillary studies
Other Name: Quality of Life Assessment

Detailed Description:

PRIMARY OBJECTIVES:

I. To determine if the addition of adjuvant chemotherapy to standard cisplatin-based chemoradiation improves overall survival.

SECONDARY OBJECTIVES:

I. To determine the progression-free survival rates. II. To determine acute and long-term toxicities. III. To determine patterns of disease recurrence. IV. To determine the association between radiation protocol compliance and outcomes.

V. To determine patient quality of life, including psycho-sexual health.

TERTIARY OBJECTIVES:

I. To determine the association between the results of a follow-up positron emission tomography (PET) scan performed 4-6 months post completion of chemoradiation and outcomes for all patients in the trial.

II. To determine the biological predictors of patients' outcomes based on translational laboratory studies of blood and tissue specimens.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive cisplatin intravenously (IV) over 60-90 minutes on days 1, 8, 15, 22, and 29. Patients also undergo external-beam radiation therapy once daily, 5 days a week, for approximately 5 weeks. Patients then undergo high-dose rate, pulsed-dose rate, or low-dose rate intracavitary brachytherapy.

ARM II: Patients receive cisplatin and undergo external-beam radiation and brachytherapy as in arm I. Beginning 4 weeks later, patients also receive adjuvant chemotherapy comprising paclitaxel IV over 3 hours and carboplatin IV over 1 hour on day 1. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.

Patients may undergo baseline tumor biopsy and blood collection for future correlative studies.

Patients complete the European Organization for Research and Treatment of Cancer (EORTC) Core questionnaire (QLQ-C30), the EORTC cervix cancer module (CX24), the ovarian cancer module (OV28), and the Sexual function-Vaginal Changes Questionnaire (SVQ) questionnaires at baseline, during, and after completion of study treatment.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Eligible patients will have locally advanced cervical cancer suitable for primary treatment with chemoradiation with curative intent, in addition to:

    • Federation of Gynecology and Obstetrics (FIGO) 2008 stage IB1 & node positive, IB2, IIA, IIB, IIIB, or IVA disease
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • Histological diagnosis of squamous cell carcinoma, adenocarcinoma or adenosquamous cell carcinoma of the cervix
  • White blood cells (WBC) >= 3.0 x 10^9/L
  • Absolute neutrophil count (ANC) >= 1.5 x 10^9/L
  • Platelet count >= 100 x 10^9/L
  • Bilirubin =< 1.5 times upper limit of normal (ULN)
  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 x ULN (if both tests are done, both results need to be =< 2.5 x ULN)
  • Creatinine =< ULN (Common Toxicity Criteria [CTC] grade 0) OR calculated creatinine clearance (Cockcroft-Gault formula) >= 60 mL/min OR >= 50 mL/min by ethylenediaminetetraacetic acid (EDTA) creatinine clearance
  • Written informed consent

Exclusion Criteria:

  • Any previous pelvic radiotherapy
  • Para-aortic nodal involvement above the level of the common iliac nodes or L3/L4 (if biopsy proven, PET positive, or >= 15 mm short-axis diameter on computed tomography [CT])
  • FIGO 2008 stage IIIA disease
  • Patients assessed at presentation as requiring interstitial brachytherapy treatment
  • Patients with bilateral hydronephrosis unless at least one side has been stented and renal function fulfills the required inclusion criteria
  • Previous chemotherapy for this tumor
  • Evidence of distant metastases
  • Prior diagnosis of Crohn's disease or ulcerative colitis
  • Peripheral neuropathy >= grade 2 (per Common Terminology Criteria for Adverse Events [CTCAE] version [v]4)
  • Patients who have undergone a previous hysterectomy or will have a hysterectomy as part of their initial cervical cancer therapy; this includes patients with a prior history of supracervical hysterectomy
  • Patients with other invasive malignancies, with the exception of non-melanoma skin cancer and in situ melanoma, who had (or have) any evidence of the other cancer present within the last 5 years
  • Patients who are pregnant or lactating
  • Any contraindication to the use of cisplatin, carboplatin, or paclitaxel chemotherapy
  • Serious illness or medical condition that precludes the safe administration of the trial treatment including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Patients who are known to be human immunodeficiency virus (HIV) positive
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01414608

  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Cancer Center Recruiting
Birmingham, Alabama, United States, 35233
Contact: Warner K. Huh    205-934-0309      
Principal Investigator: Warner K. Huh         
University of South Alabama Mitchell Cancer Institute Recruiting
Mobile, Alabama, United States, 36688
Contact: Rodney P. Rocconi    251-445-9870    pfrancisco@usouthal.edu   
Principal Investigator: Rodney P. Rocconi         
United States, Alaska
Alaska Women's Cancer Care Recruiting
Anchorage, Alaska, United States, 99508
Contact: Benjamin B. Bridges    208-381-3376    mcdonagd@slhs.org   
Principal Investigator: Benjamin B. Bridges         
Providence Alaska Medical Center Recruiting
Anchorage, Alaska, United States, 99508
Contact: Benjamin B. Bridges    208-381-3376    mcdonagd@slhs.org   
Principal Investigator: Benjamin B. Bridges         
United States, Arizona
University of Arizona Cancer Center at Saint Joseph's Recruiting
Phoenix, Arizona, United States, 85004
Contact: John H. Farley    877-602-4111      
Principal Investigator: John H. Farley         
Gynecologic Oncology Group of Arizona Recruiting
Phoenix, Arizona, United States, 85012
Contact: Kathleen N. Moore    405-271-8707    lreese@gog.org   
Principal Investigator: Kathleen N. Moore         
Saint Joseph's Hospital and Medical Center Withdrawn
Phoenix, Arizona, United States, 85013
Arizona Oncology Associates-Biltmore Cancer Center Suspended
Phoenix, Arizona, United States, 85016
Arizona Oncology Associates-West Orange Grove Recruiting
Tucson, Arizona, United States, 85704
Contact: Michael A. Bookman    520-269-3821      
Principal Investigator: Michael A. Bookman         
Arizona Oncology Associates-Wilmot Recruiting
Tucson, Arizona, United States, 85710
Contact: Michael A. Bookman    520-269-3821      
Principal Investigator: Michael A. Bookman         
United States, Arkansas
University of Arkansas for Medical Sciences Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Kristin K. Zorn    501-686-8274      
Principal Investigator: Kristin K. Zorn         
United States, California
Sutter Auburn Faith Hospital Recruiting
Auburn, California, United States, 95602
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Sutter Cancer Centers Radiation Oncology Services-Auburn Recruiting
Auburn, California, United States, 95603
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Alta Bates Summit Medical Center-Herrick Campus Recruiting
Berkeley, California, United States, 94704
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Mills - Peninsula Hospitals Recruiting
Burlingame, California, United States, 94010
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Recruiting
Cameron Park, California, United States, 95682
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
John Muir Medical Center-Concord Campus Recruiting
Concord, California, United States, 94520
Contact: Babak Edraki    925-674-2580      
Principal Investigator: Babak Edraki         
Sutter Davis Hospital Recruiting
Davis, California, United States, 95616
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Kaiser Permanente-Fremont Recruiting
Fremont, California, United States, 94538
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Memorial Medical Center Recruiting
Modesto, California, United States, 95355
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Palo Alto Medical Foundation-Camino Division Recruiting
Mountain View, California, United States, 94040
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Palo Alto Medical Foundation-Gynecologic Oncology Recruiting
Mountain View, California, United States, 94040
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Kaiser Permanente-Oakland Recruiting
Oakland, California, United States, 94611
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Saint Joseph Hospital - Orange Recruiting
Orange, California, United States, 92868
Contact: Michael L. Berman    877-827-8839    ucstudy@uci.edu   
Principal Investigator: Michael L. Berman         
UC Irvine Health/Chao Family Comprehensive Cancer Center Recruiting
Orange, California, United States, 92868
Contact: Krishnansu S. Tewari    714-456-6191    awallick@uci.edu   
Principal Investigator: Krishnansu S. Tewari         
Palo Alto Medical Foundation Health Care Recruiting
Palo Alto, California, United States, 94301
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Kaiser Permanente-Roseville Recruiting
Roseville, California, United States, 95661
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Sutter Cancer Centers Radiation Oncology Services-Roseville Recruiting
Roseville, California, United States, 95661
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Sutter Roseville Medical Center Recruiting
Roseville, California, United States, 95661
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Mercy Medical Group Recruiting
Sacramento, California, United States, 95816
Contact: Kevin S. Elliott    916-556-3200      
Principal Investigator: Kevin S. Elliott         
Sutter General Hospital Recruiting
Sacramento, California, United States, 95816
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
University of California Davis Comprehensive Cancer Center Recruiting
Sacramento, California, United States, 95817
Contact: Vanessa A. Kennedy    916-734-3089      
Principal Investigator: Vanessa A. Kennedy         
California Pacific Medical Center-Pacific Campus Recruiting
San Francisco, California, United States, 94115
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Kaiser Permanente-San Francisco Recruiting
San Francisco, California, United States, 94115
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-San Rafael Recruiting
San Rafael, California, United States, 94903
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente Medical Center - Santa Clara Recruiting
Santa Clara, California, United States, 95051
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Palo Alto Medical Foundation-Santa Cruz Recruiting
Santa Cruz, California, United States, 95065
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Sutter Pacific Medical Foundation Recruiting
Santa Rosa, California, United States, 95403
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Kaiser Permanente-South San Francisco Recruiting
South San Francisco, California, United States, 94080
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Palo Alto Medical Foundation-Sunnyvale Recruiting
Sunnyvale, California, United States, 94086
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Olive View-University of California Los Angeles Medical Center Recruiting
Sylmar, California, United States, 91342
Contact: Christine H. Holschneider    888-798-0719      
Principal Investigator: Christine H. Holschneider         
Sutter Cancer Centers Radiation Oncology Services-Vacaville Recruiting
Vacaville, California, United States, 95687
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
Kaiser Permanente-Vallejo Recruiting
Vallejo, California, United States, 94589
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Sutter Solano Medical Center/Cancer Center Recruiting
Vallejo, California, United States, 94589
Contact: John K. Chan    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: John K. Chan         
John Muir Medical Center-Walnut Creek Recruiting
Walnut Creek, California, United States, 94598
Contact: Babak Edraki    925-674-2580      
Principal Investigator: Babak Edraki         
United States, Colorado
Rocky Mountain Cancer Centers-Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
The Medical Center of Aurora Suspended
Aurora, Colorado, United States, 80012
University of Colorado Cancer Center - Anschutz Cancer Pavilion Suspended
Aurora, Colorado, United States, 80045
Boulder Community Hospital Suspended
Boulder, Colorado, United States, 80301
Rocky Mountain Cancer Centers-Boulder Recruiting
Boulder, Colorado, United States, 80304
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Mehmet S. Copur    800-998-2119      
Principal Investigator: Mehmet S. Copur         
Rocky Mountain Cancer Centers-Penrose Suspended
Colorado Springs, Colorado, United States, 80907
Porter Adventist Hospital Suspended
Denver, Colorado, United States, 80210
Colorado Blood Cancer Institute Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Presbyterian - Saint Lukes Medical Center - Health One Suspended
Denver, Colorado, United States, 80218
Rocky Mountain Cancer Centers-Midtown Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
SCL Health Saint Joseph Hospital Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Rose Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Rose Medical Center Suspended
Denver, Colorado, United States, 80220
Colorado Cancer Research Program NCORP Recruiting
Denver, Colorado, United States, 80222
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Southwest Oncology PC Suspended
Durango, Colorado, United States, 81301
Comprehensive Cancer Care and Research Institute of Colorado LLC Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Greenwood Village Suspended
Greenwood Village, Colorado, United States, 80111
Rocky Mountain Cancer Centers-Lakewood Suspended
Lakewood, Colorado, United States, 80228
Saint Anthony Hospital Suspended
Lakewood, Colorado, United States, 80228
Rocky Mountain Cancer Centers-Littleton Recruiting
Littleton, Colorado, United States, 80120
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Littleton Adventist Hospital Suspended
Littleton, Colorado, United States, 80122
Rocky Mountain Cancer Centers-Sky Ridge Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Sky Ridge Medical Center Suspended
Lone Tree, Colorado, United States, 80124
Longmont United Hospital Suspended
Longmont, Colorado, United States, 80501
Rocky Mountain Cancer Centers-Longmont Suspended
Longmont, Colorado, United States, 80501
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Parker Adventist Hospital Suspended
Parker, Colorado, United States, 80138
Rocky Mountain Cancer Centers-Parker Suspended
Parker, Colorado, United States, 80138
Saint Mary Corwin Medical Center Suspended
Pueblo, Colorado, United States, 81004
Rocky Mountain Cancer Centers - Pueblo Suspended
Pueblo, Colorado, United States, 81008
Rocky Mountain Cancer Centers-Thornton Suspended
Thornton, Colorado, United States, 80260
SCL Health Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
United States, Connecticut
University of Connecticut Withdrawn
Farmington, Connecticut, United States, 06030
Hartford Hospital Recruiting
Hartford, Connecticut, United States, 06102
Contact: Amy K. Brown    860-545-5363      
Principal Investigator: Amy K. Brown         
The Hospital of Central Connecticut Recruiting
New Britain, Connecticut, United States, 06050
Contact: Amy K. Brown    860-545-5363      
Principal Investigator: Amy K. Brown         
Yale University Recruiting
New Haven, Connecticut, United States, 06520
Contact: Peter E. Schwartz    203-785-5702      
Principal Investigator: Peter E. Schwartz         
United States, Delaware
Christiana Care Health System-Christiana Hospital Suspended
Newark, Delaware, United States, 19718
United States, Florida
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Recruiting
Deerfield Beach, Florida, United States, 33442
Contact: Aaron H. Wolfson    305-243-2647      
Principal Investigator: Aaron H. Wolfson         
University of Florida Suspended
Gainesville, Florida, United States, 32610
Jackson Memorial Hospital-Holtz Children's Hospital Recruiting
Miami, Florida, United States, 33136
Contact: Aaron H. Wolfson    305-243-2647      
Principal Investigator: Aaron H. Wolfson         
University of Miami Miller School of Medicine-Sylvester Cancer Center Recruiting
Miami, Florida, United States, 33136
Contact: Aaron H. Wolfson    305-243-2647      
Principal Investigator: Aaron H. Wolfson         
UF Cancer Center at Orlando Health Recruiting
Orlando, Florida, United States, 32806
Contact: Kathleen N. Moore    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Kathleen N. Moore         
Sarasota Memorial Hospital Suspended
Sarasota, Florida, United States, 34239
United States, Georgia
Grady Health System Recruiting
Atlanta, Georgia, United States, 30303
Contact: Joseph W. Shelton    404-778-1868      
Principal Investigator: Joseph W. Shelton         
Emory University Hospital Midtown Recruiting
Atlanta, Georgia, United States, 30308
Contact: Joseph W. Shelton    404-778-1868      
Principal Investigator: Joseph W. Shelton         
Emory University/Winship Cancer Institute Recruiting
Atlanta, Georgia, United States, 30322
Contact: Joseph W. Shelton    404-778-1868      
Principal Investigator: Joseph W. Shelton         
Northside Hospital Recruiting
Atlanta, Georgia, United States, 30342
Contact: Daniel Shasha    404-303-3355      
Principal Investigator: Daniel Shasha         
Northeast Georgia Medical Center-Gainesville Recruiting
Gainesville, Georgia, United States, 30501
Contact: Andrew E. Green    770-219-8800    cancerpatient.navigator@nghs.com   
Principal Investigator: Andrew E. Green         
Central Georgia Gynecologic Oncology Withdrawn
Macon, Georgia, United States, 31201
United States, Hawaii
The Cancer Center of Hawaii-Leeward Recruiting
'Ewa Beach, Hawaii, United States, 96706
Contact: Michael E. Carney    808-983-6090      
Principal Investigator: Michael E. Carney         
Queen's Medical Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Michael E. Carney    808-983-6090      
Principal Investigator: Michael E. Carney         
University of Hawaii Cancer Center Suspended
Honolulu, Hawaii, United States, 96813
The Cancer Center of Hawaii-Liliha Recruiting
Honolulu, Hawaii, United States, 96817
Contact: Michael E. Carney    808-983-6090      
Principal Investigator: Michael E. Carney         
Kaiser Permanente Moanalua Medical Center Recruiting
Honolulu, Hawaii, United States, 96819
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kapiolani Medical Center for Women and Children Recruiting
Honolulu, Hawaii, United States, 96826
Contact: Michael E. Carney    808-983-6090      
Principal Investigator: Michael E. Carney         
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: J. R. Liu    734-712-3456      
Principal Investigator: J. R. Liu         
Saint Luke's Mountain States Tumor Institute Recruiting
Boise, Idaho, United States, 83712
Contact: Benjamin B. Bridges    208-381-3376    mcdonagd@slhs.org   
Principal Investigator: Benjamin B. Bridges         
Kootenai Medical Center Recruiting
Coeur d'Alene, Idaho, United States, 83814
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Luke's Mountain States Tumor Institute - Fruitland Recruiting
Fruitland, Idaho, United States, 83619
Contact: Benjamin B. Bridges    208-381-3376    mcdonagd@slhs.org   
Principal Investigator: Benjamin B. Bridges         
Saint Luke's Mountain States Tumor Institute - Meridian Recruiting
Meridian, Idaho, United States, 83642
Contact: Benjamin B. Bridges    208-381-3376    mcdonagd@slhs.org   
Principal Investigator: Benjamin B. Bridges         
Saint Luke's Mountain States Tumor Institute - Nampa Recruiting
Nampa, Idaho, United States, 83686
Contact: Benjamin B. Bridges    208-381-3376    mcdonagd@slhs.org   
Principal Investigator: Benjamin B. Bridges         
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Kootenai Cancer Clinic Recruiting
Sandpoint, Idaho, United States, 83864
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Luke's Mountain States Tumor Institute-Twin Falls Recruiting
Twin Falls, Idaho, United States, 83301
Contact: Benjamin B. Bridges    208-381-3376    mcdonagd@slhs.org   
Principal Investigator: Benjamin B. Bridges         
United States, Illinois
Saint Joseph Medical Center Recruiting
Bloomington, Illinois, United States, 61701
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Bloomington Recruiting
Bloomington, Illinois, United States, 61704
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Canton Recruiting
Canton, Illinois, United States, 61520
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Carthage Recruiting
Carthage, Illinois, United States, 62321
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Centralia Oncology Clinic Recruiting
Centralia, Illinois, United States, 62801
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Eric D. Donnelly    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Eric D. Donnelly         
John H Stroger Jr Hospital of Cook County Recruiting
Chicago, Illinois, United States, 60612
Contact: Thomas E. Lad    312-864-6000      
Principal Investigator: Thomas E. Lad         
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Alfred S. Guirguis    312-942-5498    clinical_trials@rush.edu   
Principal Investigator: Alfred S. Guirguis         
University of Chicago Comprehensive Cancer Center Recruiting
Chicago, Illinois, United States, 60637
Contact: John W. Moroney       jmoroney@bsd.uchicago.edu   
Principal Investigator: John W. Moroney         
Cancer Care Center of Decatur Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Crossroads Cancer Center Recruiting
Effingham, Illinois, United States, 62401
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
NorthShore University HealthSystem-Evanston Hospital Recruiting
Evanston, Illinois, United States, 60201
Contact: Elena S. Diaz-Moore    847-570-2109      
Principal Investigator: Elena S. Diaz-Moore         
Illinois CancerCare-Galesburg Recruiting
Galesburg, Illinois, United States, 61401
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Western Illinois Cancer Treatment Center Recruiting
Galesburg, Illinois, United States, 61401
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Northwestern Medicine Cancer Center Delnor Recruiting
Geneva, Illinois, United States, 60134
Contact: LaToya J. Perry    630-315-1918    Claudine.Gamster@CadenceHealth.org   
Principal Investigator: LaToya J. Perry         
NorthShore University HealthSystem-Glenbrook Hospital Recruiting
Glenview, Illinois, United States, 60026
Contact: Elena S. Diaz-Moore    847-570-2109      
Principal Investigator: Elena S. Diaz-Moore         
NorthShore University HealthSystem-Highland Park Hospital Recruiting
Highland Park, Illinois, United States, 60035
Contact: Elena S. Diaz-Moore    847-570-2109      
Principal Investigator: Elena S. Diaz-Moore         
Sudarshan K Sharma MD Limted-Gynecologic Oncology Recruiting
Hinsdale, Illinois, United States, 60521
Contact: Sudarshan K. Sharma    630-856-6757      
Principal Investigator: Sudarshan K. Sharma         
Illinois CancerCare-Kewanee Clinic Recruiting
Kewanee, Illinois, United States, 61443
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Loyola University Medical Center Suspended
Maywood, Illinois, United States, 60153
Illinois CancerCare-Ottawa Clinic Recruiting
Ottawa, Illinois, United States, 61350
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Recruiting
Pekin, Illinois, United States, 61554
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Methodist Medical Center of Illinois Recruiting
Peoria, Illinois, United States, 61603
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Recruiting
Peoria, Illinois, United States, 61615
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Peru Recruiting
Peru, Illinois, United States, 61354
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Valley Radiation Oncology Recruiting
Peru, Illinois, United States, 61354
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Princeton Recruiting
Princeton, Illinois, United States, 61356
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Southern Illinois University School of Medicine Recruiting
Springfield, Illinois, United States, 62702
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Springfield Clinic Recruiting
Springfield, Illinois, United States, 62702
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Northwestern Medicine Cancer Center Warrenville Recruiting
Warrenville, Illinois, United States, 60555
Contact: LaToya J. Perry    630-315-1918    Claudine.Gamster@CadenceHealth.org   
Principal Investigator: LaToya J. Perry         
United States, Indiana
Michiana Hematology Oncology PC-Elkhart Recruiting
Elkhart, Indiana, United States, 46514
Contact: Kathleen N. Moore    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Kathleen N. Moore         
Indiana University/Melvin and Bren Simon Cancer Center Suspended
Indianapolis, Indiana, United States, 46202
Saint Vincent Hospital and Health Care Center Recruiting
Indianapolis, Indiana, United States, 46260
Contact: Michael J. Callahan    317-338-2194    research@stvincent.org   
Principal Investigator: Michael J. Callahan         
Saint Joseph Regional Medical Center-Mishawaka Recruiting
Mishawaka, Indiana, United States, 46545
Contact: Kathleen N. Moore    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Kathleen N. Moore         
The Community Hospital Recruiting
Munster, Indiana, United States, 46321
Contact: Mohamad Kassar    219-836-3349      
Principal Investigator: Mohamad Kassar         
United States, Iowa
University of Iowa/Holden Comprehensive Cancer Center Recruiting
Iowa City, Iowa, United States, 52242
Contact: David P. Bender    800-237-1225      
Principal Investigator: David P. Bender         
United States, Kansas
University of Kansas Cancer Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Julia A. Chapman    913-945-7552    ctnursenav@kumc.edu   
Principal Investigator: Julia A. Chapman         
United States, Kentucky
Baptist Health Lexington Recruiting
Lexington, Kentucky, United States, 40503
Contact: Hope M. Cottrill    859-260-6425      
Principal Investigator: Hope M. Cottrill         
University of Kentucky/Markey Cancer Center Recruiting
Lexington, Kentucky, United States, 40536
Contact: Frederick R. Ueland    859-257-3379      
Principal Investigator: Frederick R. Ueland         
Norton Hospital Pavilion and Medical Campus Recruiting
Louisville, Kentucky, United States, 40202
Contact: Mary E. Gordinier    502-629-2500      
Principal Investigator: Mary E. Gordinier         
United States, Louisiana
Woman's Hospital Recruiting
Baton Rouge, Louisiana, United States, 70817
Contact: M. G. Fort    225-231-5296    Ericka.Seidemann@womans.org   
Principal Investigator: M. G. Fort         
Louisiana State University Health Science Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Augusto C. Ochoa    504-568-2428    emede1@lsuhsc.edu   
Principal Investigator: Augusto C. Ochoa         
Tulane University Health Sciences Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: William R. Robinson    504-988-6121      
Principal Investigator: William R. Robinson         
University Medical Center New Orleans Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Augusto C. Ochoa    504-568-2428    emede1@lsuhsc.edu   
Principal Investigator: Augusto C. Ochoa         
Ochsner Medical Center Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Richard C. Kline    888-562-4763      
Principal Investigator: Richard C. Kline         
United States, Maine
Maine Medical Center-Bramhall Campus Terminated
Portland, Maine, United States, 04102
Maine Medical Center- Scarborough Campus Recruiting
Scarborough, Maine, United States, 04074
Contact: Christopher J. Darus    207-885-7565      
Principal Investigator: Christopher J. Darus         
United States, Maryland
University of Maryland/Greenebaum Cancer Center Suspended
Baltimore, Maryland, United States, 21201
Walter Reed National Military Medical Center Recruiting
Bethesda, Maryland, United States, 20889-5600
Contact: William J. Lowery    301-319-2100      
Principal Investigator: William J. Lowery         
United States, Massachusetts
Baystate Medical Center Recruiting
Springfield, Massachusetts, United States, 01199
Contact: Tashanna K. Myers    413-794-3565    tamara.wrenn@baystatehealth.org   
Principal Investigator: Tashanna K. Myers         
University of Massachusetts Memorial Health Care Suspended
Worcester, Massachusetts, United States, 01605
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: J. R. Liu    734-712-3456      
Principal Investigator: J. R. Liu         
Bronson Battle Creek Recruiting
Battle Creek, Michigan, United States, 49017
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Wayne State University/Karmanos Cancer Institute Recruiting
Detroit, Michigan, United States, 48201
Contact: Robert T. Morris    313-576-9363      
Principal Investigator: Robert T. Morris         
Henry Ford Hospital Recruiting
Detroit, Michigan, United States, 48202
Contact: Thomas E. Buekers    313-916-1784      
Principal Investigator: Thomas E. Buekers         
Cancer Research Consortium of West Michigan NCORP Terminated
Grand Rapids, Michigan, United States, 49503
Mercy Health Saint Mary's Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Sparrow Hospital Recruiting
Lansing, Michigan, United States, 48912
Contact: J. R. Liu    734-712-3456      
Principal Investigator: J. R. Liu         
William Beaumont Hospital-Royal Oak Recruiting
Royal Oak, Michigan, United States, 48073
Contact: Jayson B. Field    248-551-7695      
Principal Investigator: Jayson B. Field         
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Kathleen J. Yost    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
United States, Minnesota
Mercy Hospital Suspended
Coon Rapids, Minnesota, United States, 55433
Fairview-Southdale Hospital Suspended
Edina, Minnesota, United States, 55435
Abbott-Northwestern Hospital Suspended
Minneapolis, Minnesota, United States, 55407
University of Minnesota/Masonic Cancer Center Recruiting
Minneapolis, Minnesota, United States, 55455
Contact: Peter A. Argenta    612-624-2620      
Principal Investigator: Peter A. Argenta         
United Hospital Suspended
Saint Paul, Minnesota, United States, 55102
Minnesota Oncology Hematology PA-Woodbury Suspended
Woodbury, Minnesota, United States, 55125
United States, Mississippi
University of Mississippi Medical Center Recruiting
Jackson, Mississippi, United States, 39216
Contact: James T. Thigpen    601-815-6700      
Principal Investigator: James T. Thigpen         
United States, Missouri
Mercy Hospital Springfield Recruiting
Springfield, Missouri, United States, 65804
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
CoxHealth South Hospital Recruiting
Springfield, Missouri, United States, 65807
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
United States, Montana
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Vincent Healthcare Suspended
Billings, Montana, United States, 59101
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint James Community Hospital and Cancer Treatment Center Suspended
Butte, Montana, United States, 59701
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Peter's Community Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Patrick Hospital - Community Hospital Suspended
Missoula, Montana, United States, 59802
United States, Nebraska
Nebraska Methodist Hospital Recruiting
Omaha, Nebraska, United States, 68114
Contact: Peter C. Morris    402-354-7939    kathryn.bartz@nmhs.org   
Principal Investigator: Peter C. Morris         
University of Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
Contact: Kerry J. Rodabaugh    402-559-6941    unmcrsa@unmc.edu   
Principal Investigator: Kerry J. Rodabaugh         
United States, Nevada
Women's Cancer Center of Nevada Recruiting
Las Vegas, Nevada, United States, 89169
Contact: Nicola M. Spirtos    702-851-4672      
Principal Investigator: Nicola M. Spirtos         
United States, New Hampshire
Wentworth-Douglass Hospital Recruiting
Dover, New Hampshire, United States, 03820
Contact: John O. Schorge    877-726-5130      
Principal Investigator: John O. Schorge         
United States, New Jersey
Memorial Sloan Kettering Cancer Center at Basking Ridge Suspended
Basking Ridge, New Jersey, United States, 07920
Cooper Hospital University Medical Center Recruiting
Camden, New Jersey, United States, 08103
Contact: David P. Warshal    856-325-6757      
Principal Investigator: David P. Warshal         
Hackensack University Medical Center Recruiting
Hackensack, New Jersey, United States, 07601
Contact: Donna T. McNamara    201-996-2879      
Principal Investigator: Donna T. McNamara         
Morristown Medical Center Suspended
Morristown, New Jersey, United States, 07960
Virtua Memorial Withdrawn
Mount Holly, New Jersey, United States, 08060
Jersey Shore Medical Center Recruiting
Neptune City, New Jersey, United States, 07753
Contact: Karim S. ElSahwi    732-776-4240      
Principal Investigator: Karim S. ElSahwi         
Rutgers Cancer Institute of New Jersey Withdrawn
New Brunswick, New Jersey, United States, 08903
MD Anderson Cancer Center at Cooper-Voorhees Recruiting
Voorhees, New Jersey, United States, 08043
Contact: David P. Warshal    856-325-6757      
Principal Investigator: David P. Warshal         
United States, New Mexico
University of New Mexico Cancer Center Recruiting
Albuquerque, New Mexico, United States, 87102
Contact: Teresa L. Rutledge    505-925-0366    LByatt@nmcca.org   
Principal Investigator: Teresa L. Rutledge         
Southwest Gynecologic Oncology Associates Inc Recruiting
Albuquerque, New Mexico, United States, 87106
Contact: Teresa L. Rutledge    505-925-0366    LByatt@nmcca.org   
Principal Investigator: Teresa L. Rutledge         
Lovelace Radiation Oncology Recruiting
Albuquerque, New Mexico, United States, 87109
Contact: Teresa L. Rutledge    505-925-0366    LByatt@nmcca.org   
Principal Investigator: Teresa L. Rutledge         
Memorial Medical Center - Las Cruces Recruiting
Las Cruces, New Mexico, United States, 88011
Contact: Teresa L. Rutledge    505-925-0366    LByatt@nmcca.org   
Principal Investigator: Teresa L. Rutledge         
United States, New York
Women's Cancer Care Associates LLC Suspended
Albany, New York, United States, 12208
State University of New York Downstate Medical Center Suspended
Brooklyn, New York, United States, 11203
New York-Presbyterian/Brooklyn Methodist Hospital Recruiting
Brooklyn, New York, United States, 11215
Contact: Katherine Economos    718-780-3677    Adg9003@nyp.org   
Principal Investigator: Katherine Economos         
Roswell Park Cancer Institute Suspended
Buffalo, New York, United States, 14263
Memorial Sloan Kettering Commack Suspended
Commack, New York, United States, 11725
New York Hospital Medical Center of Queens Terminated
Fresh Meadows, New York, United States, 11365
Memorial Sloan Kettering Westchester Active, not recruiting
Harrison, New York, United States, 10604
Queens Hospital Center Terminated
Jamaica, New York, United States, 11432
North Shore University Hospital Recruiting
Manhasset, New York, United States, 11030
Contact: Veena S. John    516-734-8954      
Principal Investigator: Veena S. John         
Winthrop University Hospital Suspended
Mineola, New York, United States, 11501
Long Island Jewish Medical Center Recruiting
New Hyde Park, New York, United States, 11040
Contact: Veena S. John    516-734-8954      
Principal Investigator: Veena S. John         
North Shore-LIJ Health System/Center for Advanced Medicine Recruiting
New Hyde Park, New York, United States, 11040
Contact: Veena S. John    516-734-8954      
Principal Investigator: Veena S. John         
Laura and Isaac Perlmutter Cancer Center at NYU Langone Suspended
New York, New York, United States, 10016
Lenox Hill Hospital Suspended
New York, New York, United States, 10021
Memorial Sloan-Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Mario M. Leitao    212-639-7202      
Principal Investigator: Mario M. Leitao         
Highland Hospital Recruiting
Rochester, New York, United States, 14620
Contact: Richard G. Moore    585-275-5830      
Principal Investigator: Richard G. Moore         
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Richard G. Moore    585-275-5830      
Principal Investigator: Richard G. Moore         
Memorial Sloan Kettering Rockville Centre Suspended
Rockville Centre, New York, United States, 11570
Memorial Sloan Kettering Sleepy Hollow Suspended
Sleepy Hollow, New York, United States, 10591
Stony Brook University Medical Center Withdrawn
Stony Brook, New York, United States, 11794
Montefiore Medical Center-Einstein Campus Suspended
The Bronx, New York, United States, 10461
United States, North Carolina
Cone Health Cancer Center at Alamance Regional Recruiting
Burlington, North Carolina, United States, 27215
Contact: Janak K. Choksi    336-538-7725      
Principal Investigator: Janak K. Choksi         
UNC Lineberger Comprehensive Cancer Center Recruiting
Chapel Hill, North Carolina, United States, 27599
Contact: Linda Van Le    877-668-0683    cancerclinicaltrials@med.unc.edu   
Principal Investigator: Linda Van Le         
Carolinas Medical Center/Levine Cancer Institute Suspended
Charlotte, North Carolina, United States, 28203
Carolinas HealthCare System NorthEast Suspended
Concord, North Carolina, United States, 28025
New Hanover Regional Medical Center/Zimmer Cancer Center Withdrawn
Wilmington, North Carolina, United States, 28401
Southeast Clinical Oncology Research (SCOR) Consortium NCORP Suspended
Winston-Salem, North Carolina, United States, 27104
Wake Forest University Health Sciences Suspended
Winston-Salem, North Carolina, United States, 27157
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center Recruiting
Akron, Ohio, United States, 44304
Contact: Stephen J. Andrews    330-375-6101      
Principal Investigator: Stephen J. Andrews         
University of Cincinnati/Barrett Cancer Center Recruiting
Cincinnati, Ohio, United States, 45219
Contact: Eric L. Eisenhauer    513-558-4553    uchealthnews@uc.edu   
Principal Investigator: Eric L. Eisenhauer         
Case Western Reserve University Withdrawn
Cleveland, Ohio, United States, 44106
MetroHealth Medical Center Recruiting
Cleveland, Ohio, United States, 44109
Contact: Peter G. Rose    866-223-8100      
Principal Investigator: Peter G. Rose         
Cleveland Clinic Cancer Center/Fairview Hospital Suspended
Cleveland, Ohio, United States, 44111
Cleveland Clinic Foundation Suspended
Cleveland, Ohio, United States, 44195
Ohio State University Comprehensive Cancer Center Recruiting
Columbus, Ohio, United States, 43210
Contact: David M. O'Malley    800-293-5066    Jamesline@osumc.edu   
Principal Investigator: David M. O'Malley         
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    614-488-2745    sheree@columbusccop.org   
Principal Investigator: John P. Kuebler         
Miami Valley Hospital Recruiting
Dayton, Ohio, United States, 45409
Contact: Howard M. Gross    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Kettering Medical Center Recruiting
Kettering, Ohio, United States, 45429
Contact: Howard M. Gross    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Hillcrest Hospital Cancer Center Suspended
Mayfield Heights, Ohio, United States, 44124
Lake University Ireland Cancer Center Withdrawn
Mentor, Ohio, United States, 44060
University of Toledo Withdrawn
Toledo, Ohio, United States, 43614
Wright-Patterson Medical Center Suspended
Wright-Patterson Air Force Base, Ohio, United States, 45433-5529
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Robert S. Mannel    405-271-8777    ou-clinical-trials@ouhsc.edu   
Principal Investigator: Robert S. Mannel         
Oklahoma Cancer Specialists and Research Institute-Tulsa Recruiting
Tulsa, Oklahoma, United States, 74146
Contact: Robert S. Mannel    405-271-8777    ou-clinical-trials@ouhsc.edu   
Principal Investigator: Robert S. Mannel         
United States, Oregon
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Benjamin B. Bridges    208-381-3376    mcdonagd@slhs.org   
Principal Investigator: Benjamin B. Bridges         
United States, Pennsylvania
Abington Memorial Hospital Recruiting
Abington, Pennsylvania, United States, 19001
Contact: Joel I. Sorosky    215-481-2402      
Principal Investigator: Joel I. Sorosky         
Saint Luke's University Hospital-Bethlehem Campus Recruiting
Bethlehem, Pennsylvania, United States, 18015
Contact: Nicholas P. Taylor    610-954-3582    infolink@slhn.org   
Principal Investigator: Nicholas P. Taylor         
Drexel University School of Medicine Suspended
Philadelphia, Pennsylvania, United States, 19102
Gynecologic Oncology Group Recruiting
Philadelphia, Pennsylvania, United States, 19103
Contact: Philip J. DiSaia    215-854-0770    lreese@gog.org   
Principal Investigator: Kathleen N. Moore         
University of Pennsylvania/Abramson Cancer Center Suspended
Philadelphia, Pennsylvania, United States, 19104
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Pramila R. Anne    215-955-6084      
Principal Investigator: Pramila R. Anne         
UPMC-Magee Womens Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15213
Contact: Dwight E. Heron    412-647-8073      
Principal Investigator: Dwight E. Heron         
West Penn Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15224
Contact: Thomas C. Krivak    412-578-5000      
Principal Investigator: Thomas C. Krivak         
UPMC-Shadyside Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Dwight E. Heron    412-647-8073      
Principal Investigator: Dwight E. Heron         
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Bernice L. Robinson-Bennett    610-988-9323      
Principal Investigator: Bernice L. Robinson-Bennett         
United States, Rhode Island
Women and Infants Hospital Recruiting
Providence, Rhode Island, United States, 02905
Contact: Paul A. DiSilvestro    401-274-1122      
Principal Investigator: Paul A. DiSilvestro         
United States, South Carolina
AnMed Health Cancer Center Recruiting
Anderson, South Carolina, United States, 29621
Contact: David Griffin    864-512-1000      
Principal Investigator: David Griffin         
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: Jennifer L. Young Pierce    843-792-9321      
Principal Investigator: Jennifer L. Young Pierce         
Gibbs Cancer Center-Gaffney Recruiting
Gaffney, South Carolina, United States, 29341
Contact: David Griffin    864-512-1000      
Principal Investigator: David Griffin         
Saint Francis Hospital Recruiting
Greenville, South Carolina, United States, 29601
Contact: David Griffin    864-512-1000      
Principal Investigator: David Griffin         
Gibbs Cancer Center-Pelham Recruiting
Greer, South Carolina, United States, 29651
Contact: David Griffin    864-512-1000      
Principal Investigator: David Griffin         
Spartanburg Medical Center Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: David Griffin    864-512-1000      
Principal Investigator: David Griffin         
MGC Hematology Oncology-Union Recruiting
Union, South Carolina, United States, 29379
Contact: David Griffin    864-512-1000      
Principal Investigator: David Griffin         
United States, South Dakota
Black Hills Obstetrics and Gynecology Suspended
Rapid City, South Dakota, United States, 57701
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Michael O. Robinson    605-716-3982    research@rcrh.org   
Principal Investigator: Michael O. Robinson         
United States, Texas
Texas Oncology-Austin Midtown Recruiting
Austin, Texas, United States, 78705
Contact: Michael A. Bookman    520-269-3821      
Principal Investigator: Michael A. Bookman         
Texas Oncology - Central Austin Cancer Center Recruiting
Austin, Texas, United States, 78731
Contact: Michael A. Bookman    520-269-3821      
Principal Investigator: Michael A. Bookman         
Texas Oncology - South Austin Cancer Center Recruiting
Austin, Texas, United States, 78745
Contact: Michael A. Bookman    520-269-3821      
Principal Investigator: Michael A. Bookman         
Texas Oncology Bedford Recruiting
Bedford, Texas, United States, 76022
Contact: Michael A. Bookman    520-269-3821      
Principal Investigator: Michael A. Bookman         
Texas Oncology at Baylor Charles A Sammons Cancer Center Recruiting
Dallas, Texas, United States, 75246
Contact: Michael A. Bookman    520-269-3821      
Principal Investigator: Michael A. Bookman         
UT Southwestern/Simmons Cancer Center-Dallas Recruiting
Dallas, Texas, United States, 75390
Contact: David S. Miller    214-648-7097      
Principal Investigator: David S. Miller         
Texas Oncology Fort Worth at 12th Avenue Suspended
Fort Worth, Texas, United States, 76104
University of Texas Medical Branch Suspended
Galveston, Texas, United States, 77555-0565
Lyndon Baines Johnson General Hospital Recruiting
Houston, Texas, United States, 77026-1967
Contact: Lois M. Ramondetta    713-792-3245      
Principal Investigator: Lois M. Ramondetta         
M D Anderson Cancer Center Recruiting
Houston, Texas, United States, 77030
Contact: Lois M. Ramondetta    713-792-3245      
Principal Investigator: Lois M. Ramondetta         
Memorial Hermann Texas Medical Center Suspended
Houston, Texas, United States, 77030
The Methodist Hospital System Recruiting
Houston, Texas, United States, 77030
Contact: Aparna A. Kamat    713-790-2700      
Principal Investigator: Aparna A. Kamat         
West Texas Cancer Center Recruiting
Odessa, Texas, United States, 79761
Contact: Michael A. Bookman    520-269-3821      
Principal Investigator: Michael A. Bookman         
Houston Methodist Sugar Land Hospital Recruiting
Sugar Land, Texas, United States, 77479
Contact: Aparna A. Kamat    713-790-2700      
Principal Investigator: Aparna A. Kamat         
United States, Utah
Intermountain Medical Center Withdrawn
Murray, Utah, United States, 84107
Dixie Medical Center Regional Cancer Center Withdrawn
Saint George, Utah, United States, 84770
Utah Cancer Specialists-Salt Lake City Withdrawn
Salt Lake City, Utah, United States, 84106
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Matthew M. Poppe    801-581-4477    clinical.trials@hci.utah.edu   
Principal Investigator: Matthew M. Poppe         
LDS Hospital Withdrawn
Salt Lake City, Utah, United States, 84143
United States, Virginia
University of Virginia Cancer Center Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Susan C. Modesitt    434-243-6322    JME3D@hscmail.mcc.virginia.edu   
Principal Investigator: Susan C. Modesitt         
Virginia Commonwealth University/Massey Cancer Center Recruiting
Richmond, Virginia, United States, 23298
Contact: Emma C. Fields    804-628-1939      
Principal Investigator: Emma C. Fields         
Carilion Clinic Gynecological Oncology Recruiting
Roanoke, Virginia, United States, 24016
Contact: Janet L. Osborne    540-985-8510      
Principal Investigator: Janet L. Osborne         
United States, Washington
MultiCare Auburn Medical Center Recruiting
Auburn, Washington, United States, 98001
Contact: John A. Keech    253-403-2394      
Principal Investigator: John A. Keech         
MultiCare Gig Harbor Medical Park Recruiting
Gig Harbor, Washington, United States, 98335
Contact: John A. Keech    253-403-2394      
Principal Investigator: John A. Keech         
MultiCare Good Samaritan Hospital Recruiting
Puyallup, Washington, United States, 98372
Contact: John A. Keech    253-403-2394      
Principal Investigator: John A. Keech         
MultiCare Tacoma General Hospital Recruiting
Tacoma, Washington, United States, 98405
Contact: John A. Keech    253-403-2394      
Principal Investigator: John A. Keech         
United States, Wisconsin
Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311
Contact: Ali Mahdavi    800-928-1103      
Principal Investigator: Ali Mahdavi         
University of Wisconsin Hospital and Clinics Recruiting
Madison, Wisconsin, United States, 53792
Contact: Kristin A. Bradley    877-405-6866      
Principal Investigator: Kristin A. Bradley         
Aurora Saint Luke's Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Ali Mahdavi    800-928-1103      
Principal Investigator: Ali Mahdavi         
Froedtert and the Medical College of Wisconsin Suspended
Milwaukee, Wisconsin, United States, 53226
Vince Lombardi Cancer Clinic - Oshkosh Recruiting
Oshkosh, Wisconsin, United States, 54904
Contact: Ali Mahdavi    800-928-1103      
Principal Investigator: Ali Mahdavi         
Aurora West Allis Medical Center Recruiting
West Allis, Wisconsin, United States, 53227
Contact: Ali Mahdavi    800-928-1103      
Principal Investigator: Ali Mahdavi         
United States, Wyoming
Cheyenne Regional Medical Center-West Recruiting
Cheyenne, Wyoming, United States, 82001
Contact: Keren Sturtz    303-777-2663    kgeisen@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Billings Clinic-Cody Recruiting
Cody, Wyoming, United States, 82414
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Welch Cancer Center Recruiting
Sheridan, Wyoming, United States, 82801
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Canada, Ontario
Juravinski Cancer Centre at Hamilton Health Sciences Recruiting
Hamilton, Ontario, Canada, L8V 5C2
Contact: Lorraine (Laurie) M. Elit    905-387-9495      
Principal Investigator: Lorraine (Laurie) M. Elit         
London Regional Cancer Program Recruiting
London, Ontario, Canada, N6A 4L6
Contact: David P. D'Souza    519-685-8600      
Principal Investigator: David P. D'Souza         
University Health Network-Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Anthony W. Fyles    416-946-4501    clinical.trials@uhn.on.ca   
Principal Investigator: Anthony W. Fyles         
Canada, Quebec
CHUM - Hopital Notre-Dame Recruiting
Montreal, Quebec, Canada, H2L 4M1
Contact: Maroie Barkati    514-890-8000 ext 23611    sylvie.beaudoin.chum@ssss.gouv.qc.ca   
Principal Investigator: Maroie Barkati         
McGill University Department of Oncology Recruiting
Montreal, Quebec, Canada, H2W 1S6
Contact: Joanne Alfieri    514-934-1934 ext 42953    evelyn.ortega@muhc.mcgill.ca   
Principal Investigator: Joanne Alfieri         
The Research Institute of the McGill University Health Centre (MUHC) Recruiting
Montreal, Quebec, Canada, H3H 2R9
Contact: Joanne Alfieri    514-934-1934 ext 42953    evelyn.ortega@muhc.mcgill.ca   
Principal Investigator: Joanne Alfieri         
Canada, Saskatchewan
Allan Blair Cancer Centre Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Evgeny Sadikov    306-766-2213      
Principal Investigator: Evgeny Sadikov         
China, Shanghai
Zhongshan Hospital Fudan University Suspended
Guangdong Province, Shanghai, China, 200032
Saudi Arabia
King Faisal Specialist Hospital and Research Centre Active, not recruiting
Riyadh, Saudi Arabia, 11211
Singapore
National University Hospital Singapore Suspended
Singapore, Singapore, 119074
Sponsors and Collaborators
Gynecologic Oncology Group
National Cancer Institute (NCI)
Investigators
Principal Investigator: Kathleen Moore NRG Oncology
  More Information

Responsible Party: Gynecologic Oncology Group
ClinicalTrials.gov Identifier: NCT01414608     History of Changes
Other Study ID Numbers: ANZGOG-0902-GOG-0274
NCI-2011-02978 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
CDR0000706698
GOG-0274
RTOG-1174
ANZGOG-0902
ANZGOG-0902-GOG-0274 ( Other Identifier: NRG Oncology )
ANZGOG-0902-GOG-0274 ( Other Identifier: CTEP )
U10CA180868 ( U.S. NIH Grant/Contract )
U10CA027469 ( U.S. NIH Grant/Contract )
Study First Received: August 10, 2011
Last Updated: May 2, 2017

Additional relevant MeSH terms:
Carcinoma
Carcinoma, Squamous Cell
Adenocarcinoma
Uterine Cervical Neoplasms
Infertility
Carcinoma, Adenosquamous
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Squamous Cell
Uterine Neoplasms
Genital Neoplasms, Female
Urogenital Neoplasms
Neoplasms by Site
Uterine Cervical Diseases
Uterine Diseases
Genital Diseases, Female
Genital Diseases, Male
Neoplasms, Complex and Mixed
Paclitaxel
Albumin-Bound Paclitaxel
Cisplatin
Carboplatin
Antineoplastic Agents, Phytogenic
Antineoplastic Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on July 27, 2017