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Indoleamine 2,3-dioxygenase (IDO) Activity in Patients With Chronic Lymphocytic Leukemia (CLL) (KLL3)

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ClinicalTrials.gov Identifier: NCT01397916
Recruitment Status : Completed
First Posted : July 20, 2011
Last Update Posted : March 30, 2012
Sponsor:
Information provided by (Responsible Party):
MSinisalo, Tampere University Hospital

Brief Summary:
The Activity of Indoleamine 2,3-dioxygenase in patients with Chronic Lymphocytic Leukemia (CLL) is studied.

Condition or disease
CLL

Detailed Description:
The Activity of Indoleamine 2,3-dioxygenase in patients with Chronic Lymphocytic Leukemia (CLL)is studied in patients and healthly controls.

Study Type : Observational
Actual Enrollment : 73 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Activity of Indoleamine 2,3-dioxygenase in Patients With Chronic Lymphocytic Leukemia (CLL)
Study Start Date : February 2010
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010


Group/Cohort
CLL-patients
Controls



Primary Outcome Measures :
  1. IDO activity and expression measured by kynurenine/tryptophan ratio in serum and by PCR in peripheral blood mononuclear cells. [ Time Frame: 3 months ]
    Indoleamine 2,3 -dioxygenase (IDO) activity in patients with CLL was measured by the serum kynurenine/tryptophan (kyn/trp) ratio and - the expression of INDO (encoding IDO enzyme) and INDOL1 (encoding IDO2 enzyme) genes in peripheral blood mononuclear cells via TaqMan real-time PCR.


Biospecimen Retention:   Samples With DNA
Ido expression


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Ages Eligible for Study:   15 Years to 85 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients with CLL
Criteria

Inclusion Criteria:

  • Patients with CLL and lymphocyte count > 10 x 109/l

Exclusion Criteria:

  • Acute infection

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01397916


Locations
Finland
Tampere university Hospital
Tampere, Finland, 33521
Sponsors and Collaborators
Tampere University Hospital
Investigators
Principal Investigator: Marjatta Sinisalo, MD, PhD Tampere University Hospital

Responsible Party: MSinisalo, Dr, Tampere University Hospital
ClinicalTrials.gov Identifier: NCT01397916     History of Changes
Other Study ID Numbers: CLL-IDO
First Posted: July 20, 2011    Key Record Dates
Last Update Posted: March 30, 2012
Last Verified: March 2012

Keywords provided by MSinisalo, Tampere University Hospital:
CLL
IDO

Additional relevant MeSH terms:
Leukemia, Lymphoid
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Leukemia, B-Cell