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A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01331837
First Posted: April 8, 2011
Last Update Posted: July 13, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Hoffmann-La Roche
  Purpose
This randomized, open-label, parallel-group, multicenter study will evaluate the rate of cardiovascular events with tocilizumab in comparison to etanercept in participants with rheumatoid arthritis (RA). Participants will be randomized to receive intravenous (IV) 8 milligrams per kilogram (mg/kg) tocilizumab every 4 weeks or subcutaneous 50 milligrams (mg) etanercept weekly, with or without non-biologic disease-modifying anti-rheumatic drug (DMARD).

Condition Intervention Phase
Rheumatoid Arthritis Drug: Etanercept Drug: Tocilizumab Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Clinical Outcomes Study to Evaluate the Effects of IL-6 Receptor Blockade With Tocilizumab (TCZ) in Comparison With Etanercept (ETA) on the Rate of Cardiovascular Events in Patients With Moderate to Severe Rheumatoid Arthritis (RA)

Resource links provided by NLM:


Further study details as provided by Hoffmann-La Roche:

Primary Outcome Measures:
  • Time to First Cardiovascular (CV) Events Adjudication Committee (EAC) (CV-EAC) Adjudicated Event [ Time Frame: From baseline up to 4.9 years ]
    Prospective comparison of time to first occurrence of any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke.

  • Percentage of Patients Reporting a Cardiovascular (CV) Events Adjudication Committee (EAC) (CV-EAC) Adjudicated Event [ Time Frame: From baseline up to 4.9 years ]
    Percentage of patients reporting any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke

  • Time to First CV-EAC Adjudicated Event - Sensitivity Analysis [ Time Frame: From Baseline up to 4.9 years ]
    Prospective comparison of time to first occurrence of any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analysis

  • Percentage of Patients With a CV-EAC Adjudicated Event - Sensitivity Analysis [ Time Frame: From Baseline up to 4.9 years ]
    Percentage of patients with any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analysis

  • Time to First CV-EAC Adjudicated Event Excluding Undetermined Cause of Death - Sensitivity Analysis [ Time Frame: From baseline up to 4.9 years ]
    Prospective comparison of time to first occurrence of any component of the composite of CV death (excluding events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analyses

  • Percentage of Patients With a CV-EAC Adjudicated Event Excluding Undetermined Cause of Death - Sensitivity Analysis [ Time Frame: From baseline up to 4.9 years ]
    Percentage of patients with any component of the composite of CV death (excluding events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analyses

  • Time to First CV-EAC Adjudicated Event Before Last Direct Contact Date [ Time Frame: From Baseline up to 4.9 years ]
    Prospective comparison of time to first occurrence of any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke before last direct contact date (i.e., latest date of visit, IVRS call, or site call).

  • Percentage of Participants With a CV-EAC Adjudicated Event Before Last Direct Contact Date [ Time Frame: From Baseline up to 4.9 years ]
    Percentage of participants with any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke before last direct contact date (i.e., latest date of visit, IVRS call, or site call).


Secondary Outcome Measures:
  • The Time to First Occurrence of an Expanded CV Composite Endpoint [ Time Frame: From baseline up to 4.9 years ]
    Prospective comparison of the time to first ccurrence of the expanded composite endpoint. The expanded composite endpoint is defined as the CV composite of the primary endpoint with the addition of non-elective coronary revascularization procedures and hospitalization for unstable angina.

  • Percentages of Participants With an Expanded CV Composite Endpoint [ Time Frame: From baseline up to 4.9 years ]
    Percentages of participants with the expanded CV composite endpoint. The expanded composite endpoint is defined as the CV composite of the primary endpoint with the addition of non-elective coronary revascularization procedures and hospitalization for unstable angina.

  • Time to First Occurrence of Individual Component of Primary Endpoint: Non-fatal Myocardial Infarction [ Time Frame: From baseline up to 4.9 years ]
    Prospective comparison of time to first occurrence of Individual component of primary endpoint: non-fatal Myocardial Infarction

  • Percentage of Patients With Individual Component of Primary Endpoint: Non-fatal Myocardial Infarction [ Time Frame: From baseline up to 4.9 years ]
    Percentage of patients reporting Individual component of primary endpoint: non-fatal Myocardial Infarction

  • Time to First Occurrence of Individual Component of Primary Endpoint: Cardiovascular Death [ Time Frame: From baseline up to 4.9 years ]
    Prospective comparison of time to first occurrence of Individual component of primary endpoint: cardiovascular death

  • Percentage of Patients With Individual Component of Primary Endpoint: Cardiovascular Death [ Time Frame: From baseline up to 4.9 years ]
    Percentage of patients reporting Individual component of primary endpoint: cardiovascular death

  • Time to First Occurrence of Individual Component of Primary Endpoint: Non-fatal Stroke [ Time Frame: From baseline up to 4.9 years ]
    Prospective comparison of time to first occurrence of Individual component of primary endpoint: non-fatal stroke

  • Percentage of Patients With Individual Component of Primary Endpoint: Non-fatal Stroke [ Time Frame: From baseline up to 4.9 years ]
  • Time to First Occurrence of Individual Component of Primary Endpoint: All-cause Mortality [ Time Frame: From baseline up to 4.9 years ]
    Prospective comparison of time to first occurrence of Individual component of primary endpoint: All-cause mortality

  • Percentage of Patients With Individual Component of Primary Endpoint: All-cause Mortality [ Time Frame: From baseline up to 4.9 years ]
    Percentage of patients reporting Individual component of primary endpoint: All-cause mortality


Enrollment: 3080
Actual Study Start Date: August 2, 2011
Study Completion Date: March 25, 2016
Primary Completion Date: March 25, 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Etanercept Drug: Etanercept
Participants will receive 50 mg etanercept subcutaneously weekly until switch to another RA therapy or up to 4.9 years.
Experimental: Tocilizumab Drug: Tocilizumab
Participants will receive 8 mg/kg tocilizumab IV every 4 weeks until switch to another RA therapy or up to 4.9 years.
Other Name: Actemra

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   50 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Participants with moderate to severe RA of greater than or equal to (>=6) months duration
  • Inadequate response to at least one non-biologic DMARD
  • Positive for Rheumatoid Factor (RF) and/or anti-cyclic citrullinated peptide (CCP) antibodies at screening
  • Have C-reactive protein (CRP) greater than (>) 0.3 milligrams per deciliter (mg/dL) at screening or at the baseline visit
  • Swollen joint count (SJC) >=8 (66 joint count) and tender joint count (TJC) >= 8 (68 joint count) during screening or at the baseline visit
  • History of Coronary Heart Disease (CHD) or presence of one or more additional CHD risk factors, including current cigarette smoking, hypertension, low High Density Lipoprotein (HDL) cholesterol, family history of premature CHD, diabetes, presence of extra-articular disease associated with rheumatoid arthritis
  • At the time of randomization, will have discontinued infliximab, adalimumab, golimumab, or certolizumab for >= 4 weeks

Exclusion Criteria:

  • Major surgery (including joint surgery or coronary revascularization) within 8 weeks prior to screening or planned major surgery within 1 year of study start
  • Rheumatic autoimmune disease other than RA
  • History of or current inflammatory joint disease other than RA
  • Current or recent (within past 3 months) evidence of serious uncontrolled concomitant cardiovascular or cerebrovascular disease (myocardial infarction, revascularization, stroke, transient ischemic attack, or acute coronary syndrome)
  • Current or previous (within the past 2 years) evidence of serious uncontrolled concomitant pulmonary (including obstructive pulmonary disease), renal, hepatic, endocrine (including uncontrolled diabetes mellitus) or gastrointestinal disease
  • Uncontrolled disease states, such as asthma or inflammatory bowel disease where flares are commonly treated with oral or parenteral corticosteroids
  • Pre-existing central nervous system demyelinating or seizure disorders
  • History of diverticulitis, diverticulosis requiring treatment or other lower gastrointestinal tract conditions that might predispose to perforations
  • Current liver disease as determined by the investigator; a history of asymptomatic elevations in liver function tests (LFTs) is not considered an exclusion
  • Active current infection or history of recurrent bacterial, viral, fungal, mycobacterial or other infections, including but not limited to tuberculosis and atypical mycobacterial disease, hepatitis B and C, and herpes zoster, but excluding fungal infections of nail beds
  • Any major episode of infection requiring hospitalization or treatment with IV antibiotics within four weeks of screening or oral antibiotics within two weeks prior to screening visit
  • Active tuberculosis (TB) requiring treatment within 3 years prior to baseline
  • Latent TB diagnosed during screening that has not been appropriately treated
  • Primary or secondary immunodeficiency (history of or currently active)
  • Moderate to severe heart failure
  • Evidence of active malignant disease, malignancies diagnosed within the previous 10 years (including hematologic malignancies and solid tumors, except basal cell carcinoma of the skin that has been excised and cured), or breast cancer diagnosed within the previous 20 years
  • Breast feeding mothers
  • History of alcohol, drug or chemical abuse within the 6 months prior to screening
  • Participants with lack of peripheral venous access
  • Participants with a history of allergic reactions to latex
  • Previous treatment with non-tumor necrosis factor (non-TNF)-inhibitor biologic therapy
  • Treatment with any investigational agent within 4 weeks of screening visit
  • Treatment with any cell depleting therapies within 1 year of baseline
  • Treatment with IV gamma globulin, plasmapheresis or Prosorba column within 6 months of baseline visit
  • Immunization with a live/attenuated vaccine within 4 weeks prior to baseline visit
  • Any previous treatment with alkylating agents, such as cyclophosphamide or chlorambucil, or with total lymphoid irradiation
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01331837


  Hide Study Locations
Locations
United States, Alabama
Uni Of Alabama,Birmingham; Medicine - Rheumatology
Birmingham, Alabama, United States, 35294
Rheumatology Associates of North Alabama
Huntsville, Alabama, United States, 35801
Clinical and Translational Research Center of Alabama, PC
Tuscaloosa, Alabama, United States, 35406
United States, Arizona
Arizona Arthritis & Rheumatology Associates, P.C.
Glendale, Arizona, United States, 85306
Arizona Arthritis & Rheumatology Research, Pllc
Paradise Valley, Arizona, United States, 85253
Sun Valley Arthritis Center
Peoria, Arizona, United States, 85381
Valley Arthritis Care
Phoenix, Arizona, United States, 85027
Advanced Arthritis Care & Research
Scottsdale, Arizona, United States, 85258
Camp Lowell Medical Specialists
Tucson, Arizona, United States, 85715
The University of Arizona
Tucson, Arizona, United States, 85724
United States, Arkansas
NEA Baptist Clinic
Jonesboro, Arkansas, United States, 72401
OrthoArkansas; Orthopedics & Sports Medicine
Little Rock, Arkansas, United States, 72205
United States, California
Samy Metyas, MD, Inc
Covina, California, United States, 91723
Talbert Medical Group
Huntington Beach, California, United States, 92646
Allergy & Rheumatology Medical Clinic, Inc
La Jolla, California, United States, 92037
Valerius Medical Group
Los Alamitos, California, United States, 90720
Clinical Interventions Research Institute
Mission Viejo, California, United States, 92692
Dr. Brigid Freyne, MD
Murrieta, California, United States, 92563
Sharp Rees-Stealy Medical Group
Poway, California, United States, 92064
San Diego Arthritis Med Clnc
San Diego, California, United States, 92108
Purushotham & Akther Kotha Inc
San Diego, California, United States, 92120
C Michael Neuwelt MD Inc
San Leandro, California, United States, 94578
Pacific Arthritis Ctr Med Grp
Santa Maria, California, United States, 93454
Orrin M. Troum, Md
Santa Monica, California, United States, 90404
Harbor UCLA Medical Center
Torrance, California, United States, 90509
Inland Rheumatology; Clinical Trials, Inc.
Upland, California, United States, 91786
Medvin Clinical Research
Whittier, California, United States, 90606
United States, Colorado
Arthritis Assoc & Osteoporosis; Ctr of Colorado Springs
Colorado Springs, Colorado, United States, 80920
United States, Connecticut
Joao Nascimento
Bridgeport, Connecticut, United States, 06606
University of Connecticut Health Center
Farmington, Connecticut, United States, 06030
Arthritis & Osteoporosis Center Pc
Hamden, Connecticut, United States, 06518
United States, Florida
ZASA Clinical Research
Boynton Beach, Florida, United States, 33472
DC Health Clinic
Coral Gables, Florida, United States, 33134
Tsai, Yong
Daytona Beach, Florida, United States, 32117
Jacksonville Center For Clinical Research
Jacksonville, Florida, United States, 32216
Pharmax Research Clinic Inc.
Miami, Florida, United States, 33126
Arthritis/Osteoporosis Treatment Center
Orange Park, Florida, United States, 32073
Arthritis Rsrch of Florida, Inc.
Palm Harbor, Florida, United States, 34684
Baptist Hospital Clinical Research
Pensacola, Florida, United States, 32501
Pinellas Medical Research, LLC
Saint Petersburg, Florida, United States, 33708
Lovelace Scientific Resources
Sarasota, Florida, United States, 34292
Centre for Arthritis and Rheumatic Diseases
South Miami, Florida, United States, 33143
SW Florida Clinical Research
Tampa, Florida, United States, 33609
Healthpoint Medical group, Inc
Tampa, Florida, United States, 33614
United States, Georgia
Emory Uni ; Division of Rheumatology
Atlanta, Georgia, United States, 30303
Arthritis & Rheumatology of Georgia
Atlanta, Georgia, United States, 30342
North Georgia Rheumatology
Duluth, Georgia, United States, 30096
Harbin Clinic
Rome, Georgia, United States, 30165
St. Joseph'S/Candler Health System, Inc.; Office of Research
Savannah, Georgia, United States, 31405
United States, Idaho
Sonora Clinical Research
Boise, Idaho, United States, 83702
St. Luke's Intermountain Research Center
Boise, Idaho, United States, 83702
Selah Medical Ctr
Boise, Idaho, United States, 83704
Coeur D'Alene Arthritis Clinic
Coeur d'Alene, Idaho, United States, 83814
Idaho Arthritis Center
Meridian, Idaho, United States, 83642
United States, Illinois
University of Illinois at Chicago
Chicago, Illinois, United States, 60612
Apex Medical Research, AMR, Inc.
Chicago, Illinois, United States, 60616
Methodist Medical Center of Ilinois
Peoria, Illinois, United States, 61602
United States, Indiana
Northern Indiana Research Alliance
Fort Wayne, Indiana, United States, 46804
Diagnostic Rheumatology & Research
Indianapolis, Indiana, United States, 46227
Memorial Medical Group Clinical Research
South Bend, Indiana, United States, 46601
United States, Kentucky
Graves Gilbert Clinic
Bowling Green, Kentucky, United States, 42101
Research Integrity
Owensboro, Kentucky, United States, 42303
United States, Louisiana
Arthritis & Diabetes Clinic, Inc
Monroe, Louisiana, United States, 71203
Ochsner Health System
New Orleans, Louisiana, United States, 70121
United States, Maryland
Rheumatology Associates of Baltimore
Baltimore, Maryland, United States, 21286
Osteoporosis & Clinical Trials Center
Hagerstown, Maryland, United States, 21740
Center For Rheumatology & Bone Research
Wheaton, Maryland, United States, 20902
United States, Massachusetts
Phase Iii Clinical Research
Fall River, Massachusetts, United States, 02720
UMass Memorial Medical Center
Worcester, Massachusetts, United States, 01605
Clinical Pharmacology Study Group
Worcester, Massachusetts, United States, 01610
United States, Michigan
Hurley Research Center
Flint, Michigan, United States, 48503
Rheumatology, P.C.; Medical Arts Building
Kalamazoo, Michigan, United States, 49009
Advanced Rheumatology, PC
Lansing, Michigan, United States, 48910
Northern Michigan Regional Hospital
Petoskey, Michigan, United States, 49770
United States, Minnesota
St. Paul Rheumatology
Eagan, Minnesota, United States, 55121
Va Medical Center
Minneapolis, Minnesota, United States, 55417
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905
United States, Mississippi
Jackson Arthritis Clinic
Flowood, Mississippi, United States, 39232
North Mississippi Med Clinics, Inc.
Tupelo, Mississippi, United States, 38801
United States, Montana
Glacier View Research Institute
Kalispell, Montana, United States, 59901
United States, Nebraska
Univ of Nebraska Medical Ctr
Omaha, Nebraska, United States, 68198
United States, Nevada
Advanced Biomedical Research of America
Las Vegas, Nevada, United States, 89123
Innovative Health Research
Las Vegas, Nevada, United States, 89128
United States, New Hampshire
Dartmouth-Hitchcock Medical Center, Rheumatology 5C
Lebanon, New Hampshire, United States, 03756
Nashua Rheumatology - Foundation Medical Partners
Nashua, New Hampshire, United States, 03060
United States, New Jersey
Summit Medical Group
Berkeley Heights, New Jersey, United States, 07922
Rheumatology Associates Of New Jersey
Teaneck, New Jersey, United States, 07666
Arthritis Rheumatic & Back Disease Associates
Voorhees, New Jersey, United States, 08043
United States, New Mexico
Albuquerque Center For Rheumatology
Albuquerque, New Mexico, United States, 87102
Arthritis and Osteoporosis Associates of New Mexico
Las Cruces, New Mexico, United States, 88011
United States, New York
Arthritis & Osteoporosis Medical Associates, Pllc
Brooklyn, New York, United States, 11201
SUNY Downstate Medical Center.
Brooklyn, New York, United States, 11203
DiGiovanna Inst for Med Ed&Res
North Massapequa, New York, United States, 11758
Southern Tier Arthritis & Rheumatism
Olean, New York, United States, 14760
Arthritis Health Associates; Clinical Research
Syracuse, New York, United States, 13210
United States, North Carolina
Asheville Arthritis & Osteoporosis Center, PA
Asheville, North Carolina, United States, 28803
Joint & Muscle Research Institute
Charlotte, North Carolina, United States, 28204
Carolina Bone & Joint P.A.
Charlotte, North Carolina, United States, 28210
Durham Rheumatology
Durham, North Carolina, United States, 27704
PMG Research of Hickory LLC
Hickory, North Carolina, United States, 28602
Shanahan Rheumatology & Immunology, PLLC
Raleigh, North Carolina, United States, 27617
Specialty Medical Clinic and Research Center
Sanford, North Carolina, United States, 27330
Carolina Arthritis Associates, Pa
Wilmington, North Carolina, United States, 28401
United States, North Dakota
Trinity Health Center
Minot, North Dakota, United States, 58701
United States, Ohio
Cincinnati Rheumatic Disease Study Group
Cincinnati, Ohio, United States, 45219
University Hospitals Case Medical Center
Cleveland, Ohio, United States, 44109
Ohio State Univ Med Center
Columbus, Ohio, United States, 43210
Columbus Arthritis Center
Columbus, Ohio, United States, 43215
Clinical Research Source, Inc.
Toledo, Ohio, United States, 43606
Toledo Clinic
Toledo, Ohio, United States, 43623
United States, Oklahoma
Lynn Health Science Institute
Oklahoma City, Oklahoma, United States, 73112
United States, Pennsylvania
Altoona Center For Clinical Research
Duncansville, Pennsylvania, United States, 16635
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Ilumina Clinical Associates
Indiana, Pennsylvania, United States, 15701
PMA Medical Specialists
Limerick, Pennsylvania, United States, 19468
Pivotal Clinical Research, Llc
Perkasie, Pennsylvania, United States, 18944
Arthritis Group
Philadelphia, Pennsylvania, United States, 19152
University of Pittsburgh Medical Center Health System; Infectious Disease
Pittsburgh, Pennsylvania, United States, 15213-2582
Allegheny Rheumatology
Wexford, Pennsylvania, United States, 15090
Clinical Research Center of Reading
Wyomissing, Pennsylvania, United States, 19610
Pennsylvania Regional Center for Arthritis and Osteoporosis Research
Wyomissing, Pennsylvania, United States, 19610
United States, South Carolina
Columbia Arthritis Center (Partnership Practice)
Columbia, South Carolina, United States, 29204
South Carolina Research Center
Myrtle Beach, South Carolina, United States, 29572
United States, South Dakota
Brown Clinic
Watertown, South Dakota, United States, 57201
United States, Tennessee
Ramesh Gupta - PP
Memphis, Tennessee, United States, 38119
United States, Texas
Amarillo Center For Clinical Research
Amarillo, Texas, United States, 79124
Adriana Pop-Moody MD Clinic PA
Corpus Christi, Texas, United States, 78404
Metroplex Clinical Research
Dallas, Texas, United States, 75231
Leading Edge Research, PA; Office of Dr. Burbano
Fort Worth, Texas, United States, 76109
Rheumatic Disease Clin Res Ctr
Houston, Texas, United States, 77004
Houston Inst. For Clinical Research
Houston, Texas, United States, 77074
Southwest Rheumatology
Mesquite, Texas, United States, 75150
Leading Edge Research, PA; Office of Dr. Burbano
Richardson, Texas, United States, 75080
Texas Arthritis Research Center
San Antonio, Texas, United States, 78217
Arthritis & Osteoporosis Clinic
Waco, Texas, United States, 76710
United States, Virginia
Arthritis and Rheumatic Disease Associates
Burke, Virginia, United States, 22015
Sentara Medical Group
Norfolk, Virginia, United States, 23510
United States, Washington
Apex Clinical Research
Kennewick, Washington, United States, 99336
Seattle Rheumatology Associates
Seattle, Washington, United States, 98104
Office of George Krick, Md
Tacoma, Washington, United States, 98405
United States, West Virginia
Rheum & Pulmonary Clinic
Beckley, West Virginia, United States, 25801
Mountain State Clinical Research
Clarksburg, West Virginia, United States, 26301
United States, Wisconsin
Arthritis Centre; Suite 103
Racine, Wisconsin, United States, 53406
Argentina
Organizacion Medica de Investigacion
Buenos Aires, Argentina, C1015ABO
CEIM Consultorios Especializados en Investigaciones Médicas
Buenos Aires, Argentina, C1117ABK
APRILLUS
Buenos Aires, Argentina, C1194AAO
Instituto centenario
Buenos Aires, Argentina, C1204AAD
Fundación CIDEA
Buenos Aires, Argentina, C1425DTG
Atencion Integral En Reumatologia Buenos Aires
Buenos Aires, Argentina, C1426AAL
CEMIC
Buenos Aires, Argentina, C1431FWO
Hospital General de Agudos Dr. J. M. Ramos Mejia
Ciudad Autonoma Buenos Aires, Argentina, C1221ADC
Hospital Britanico de Buenos Aires
Ciudad Autonoma Buenos Aires, Argentina, C1284AEB
Centro de Investigaciones Reumatologicas y Osteologicas
Ciudad Autonoma de Buenos Aires, Argentina, 1111
Hospital Privado Cordoba
Cordoba Pcia, Argentina, 5016
Instituto Reumatológico Strusberg
Cordoba, Argentina, 5000
Hospital Italiano de Cordoba
Cordoba, Argentina, X5004BAL
Centro de Investigaciones Médicas - CIM
Florencio Varela, Argentina, 1888
Hospital Municipal Nuestra Sra. de Lujan
Lujan, Argentina, 6700
Centro de Investigacion Pergamino SA
Pergamino, Argentina, B2700CPM
Instituto Centralizado de Asistencia e Investigaci
Rosario, Santa Fe, Argentina, S2000PBJ
Sanatorio Parque de Rosario
Rosario, Argentina, S2000DSV
CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica
San Juan, Argentina, 5400
Centro Médico Privado de Reumatología
San Miguel de Tucuman, Argentina, T4000AXL
Centro de Investigaciones Reumatologicas Tucuman
Tucuman, Argentina, 4000
Austria
Lkh-Univ. Klinikum Graz
Graz, Austria, 8036
Landesklinikum Weinviertel Stockerau; Rheumatologie
Stockerau, Austria, 2000
Medizinische Universität Wien
Wien, Austria, 1090
Rheuma-Zentrum Favoriten Wien
Wien, Austria, 1100
Krankenhaus Hietzing; 2.Med.Abteilung, Pav.3A
Wien, Austria, 1130
Belgium
CHU St Pierre (St Pierre)
Brussels, Belgium, 1000
Cliniques Universitaires St-Luc
Bruxelles, Belgium, 1200
AZ Groeninge (Vercruysselaan)
Kortrijk, Belgium, 8500
CHU Sart-Tilman
Liège, Belgium, 4000
ZNA Jan Palfijn
Merksem, Belgium, 2170
Bosnia and Herzegovina
University Clinical Center of the Republic of Srpska
Banja Luka, Bosnia and Herzegovina, 78000
University Clinic Ctr Sarajevo
Sarajevo, Bosnia and Herzegovina, 71 000
General Hospital Prim.dr.Abdulah Nakas
Sarajevo, Bosnia and Herzegovina, 71000
Uni Hospital Center Tuzla
Tuzla, Bosnia and Herzegovina, 75000
Canada, Alberta
Royal Alexandra Hospital
Edmonton, Alberta, Canada, T5H 3V9
Canada, British Columbia
The Medical Arts Health Research Group
Powell River, British Columbia, Canada, V8A 3B6
Baker, Milton F.
Victoria, British Columbia, Canada, V8P 5P6
Canada, Newfoundland and Labrador
Nexus Clinical Research Centre
St John's, Newfoundland and Labrador, Canada, A1A 5E8
St. Clare'S Mercy Hospital
St John's, Newfoundland and Labrador, Canada, A1C 5B8
Canada, Ontario
Arthur Karasik, MD
Etobicoke, Ontario, Canada, M9C 5N2
Charlton Medical Center
Hamilton, Ontario, Canada, L8N 1Y2
K-W Musculoskeletal Research
Kitchener, Ontario, Canada, N2M 5N6
St. Joseph's Hospital
London, Ontario, Canada, N6A 4V2
Credit Valley, Rheumatology
Mississauga, Ontario, Canada, L5M 2V8
Niagara Peninsula Arthritis Centre
St. Catharines, Ontario, Canada, L2N 7E4
Mount Sinai Hospital
Toronto, Ontario, Canada, M5G 1Z5
Canada, Quebec
Institut de Rhumatologie de Montreal
Montreal, Quebec, Canada, H2L 1S6
Groupe de Recherche En Rhumatologie Et Maladies Osseuses
Quebec City, Quebec, Canada, G1V 3M7
Chus Hopital Fleurimont
Sherbrooke, Quebec, Canada, J1H 5N4
Centre de Recherche Musculo-Squelettique
Trois-rivieres, Quebec, Canada, G8Z 1Y2
Canada
Centre Re Recherche Saint-Louis
Quebec, Canada, G1W 4R4
Chile
Hospital San Juan de Dios La Serena
La Serena, Chile, 1700000
Centro Medico Prosalud
Santiago, Chile, 7500000
Interin
Santiago, Chile, 7500035
Centro de Estudios Reumatológicos
Santiago, Chile, 7501126
Hospital Clinico Pontificia Universidad Catolica de Chile
Santiago, Chile, 8320112
Centro de Investigacion Clinica del Sur
Temuco, Chile, 4780000
Clinica Alemana de Temuco
Temuco, Chile, 4780000
Hospital Clinico Viña del Mar- Oncovida
Viña del Mar, Chile, 2520612
Centro de Estudios Clinicos V Region Limitada
Viña del Mar, Chile
Croatia
General Hospital Karlovac
Karlovac, Croatia, 47000
Special Hospital for Medical Rehabilitation
Krapinske Toplice, Croatia, 49217
Clinical Hospital Centre Rijeka; Department of Rheumatology and Clinical Immunology
Rijeka, Croatia, 51000
Clinical Hospital Centre Zagreb
Zagreb, Croatia, 10000
Universtiy Hospital Dubrava
Zagreb, Croatia, 10000
Czechia
Fakultni nemocnice u sv. Anny v Brne
Brno, Czechia, 656 91
Revmatologicka ambulance
Bruntal, Czechia, 792 01
Revmatologicka Ambulance
Hlucin, Czechia, 748 01
Interni a revmatologicka ordinace
Hostivice, Czechia, 253 01
Revmatologicka a-interni ambulance
Kladno, Czechia, 272 01
Revmatologie MUDr. Klara Sirova s.r.o.
Ostrava - Moravska Ostrava, Czechia, 702 00
Revmatologicka ambulance
Praha 4, Czechia, 140 00
Revmatologicky Ustav
Praha, Czechia, 128 50
Fakultni Thomayerova nemocnice s poliklinikou
Praha, Czechia, 140 59
Artroscan s.r.o.
Sokolov, Czechia, 356 01
Revmatologicka Ambulance-Terezin
Terezin, Czechia, 411 55
PV - Medical, s.r.o.
Zlin, Czechia, 748 01
Ecuador
Hospital Clínica Santa Inés
Cuenca, Ecuador, 101168
Centro de Reumatología y Rehabilitación
Guayaquil, Ecuador, 593
OMNI Hospital
Guayaquil, Ecuador, 593
Centro Medico Alcivar 4
Guayaquil, Ecuador, EC090114
Centro Medico Picasso
Quito, Ecuador, 005932
Novaclinica Santa Cecilia; Reumatology
Quito, Ecuador, EC170517
France
CHU d'Amiens Hôpital Nord; Pharmacie Clinique
Amiens, France, 80054
Groupe Hospitalier Pellegrin
Bordeaux, France, 33000
CHU Hopital Gabriel Montpied
Clermont Ferrand, France, 63003
Centre Hospitalier Sud Francilien
Corbeil Essonnes, France, 91106
CHU Grenoble Sud
Echirolles, France, 38434
Hôpital Edouard Herriot; Service de Rhumatologie
Lyon, France, 69003
CHR Orleans, Hopital Madeleine
Orléans, France, 45067
Hôpital Saint-Antoine; Service de Psychiatrie
Paris, France, 75571
Groupe Hospitalier Pitie-Salpetriere
Paris, France, 75651
Hopital Cochin; Gastro Enterologie
Paris, France, 75679
Hôpital Sud - CHU de Rennes
Rennes, France, 35033
Hôpital Victor Provo
Roubaix, France, 59056
CHU de Rouen, Hopital de Bois Guillaume; Service de Rhumatologie
Rouen, France, 76031
CHU Saint-Etienne, Hopital Bellevue
Saint-Etienne, France, 42055
Hôpital General - CHRU de Dijon
Strasbourg, France, 67098
Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O)
Toulouse, France, 31059
Germany
Charité Universitaetsmedizin Berlin, Campus Charité Mitte
Berlin, Germany, 10117
Schlosspark-Klinik
Berlin, Germany, 14059
Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden
Dresden, Germany, 01307
Universitätsklinikum Erlangen; Augenklinik
Erlangen, Germany, 91054
Praxisgemeinschaft Rheumatologie-Nephrologie Erlangen PGRN
Erlangen, Germany, 91056
Universitaetsklinikum Frankfurt
Frankfurt, Germany, 60528
Universitaetsklinikum Hamburg-Eppendorf; Medizinische Klinik Nephrologie/Rheumatologie
Hamburg, Germany, 20251
Schön Klinik Hamburg-Eilbek Klinik für Rheumatologie
Hamburg, Germany, 22081
Rheumazentrum Ruhrgebiet; St. Josefs-Krankenhaus
Herne, Germany, 44649
Gemeinschaftspraxis Dr. Von Hinueber/Dr. Demary; Rheumatologie
Hildesheim, Germany, 31134
Universitätsklinikum Köln, Klinik I für Innere Medizin
Koeln, Germany, 50937
Universitaetsklinikum Leipzig
Leipzig, Germany, 04103
Praxiszentrum St. Bonifatius
Muenchen, Germany, 81541
Ludwig Maximilians; Universitaet
München, Germany, 80337
Rheumatologische Gemeinschaftspraxis
Osnabrueck, Germany, 49074
Evangelisches Fachkrankenhaus
Ratingen, Germany, 40882
Greece
Laiko General Hospital Athen
Athens, Greece, 115 27
Euroclinic of Athens; Internal Medicine & Immunology Dept.
Athens, Greece, 15121
University General Hospital of Heraklion
Crete, Greece, 71110
University General Hospital of Larissa; Rheumatology Unit
Larissa, Greece, 411 10
General Hospital of Thessaloniki Hippokration
Thessaloniki, Greece, 54 642
Euromedica Kyanous Stavros General Hospital
Thessaloniki, Greece, 546 36
424 Military Training Hospital-Egnatia
Thessaloniki, Greece
Hungary
Országos Fizioterápiás És Reumatológiai Intézet; I. Reumatológiai És Metabolikus Osteológiai Osztály
Budapest, Hungary, 1027
Clinexpert Egeszsegugyi Szolgaltato es Kereskedelmi Kft
Budapest, Hungary, 1033
Obudai Egeszsegugyi Centrum Kft.
Budapest, Hungary, 1036
Synexus Magyarorszag Kft
Budapest, Hungary, 1036
Debreceni Egyetem, Klinikai Kozpont, Tudogyogyaszati Klinika
Debrecen, Hungary, 4032
Markhot Ferenc Eu. Szolg. Nonprofit Kiem. Kozh. Kft.
Eger, Hungary, 3300
Bekes Megyei Kepviselotestulet Pandy Kalman Korhaza
Gyula, Hungary, 5700
Varosi Korhaz-Rendelointezet
Mor, Hungary, 8060
Fejer Megyei Szent Gyorgy Korhaz
Szekesfehervar, Hungary, 8000
Clinfan Szolgaltato Kft.
Szekszard, Hungary, 7100
Zala Megyei Korhaz; Reumatologia
Zalaegerszeg, Hungary, 8901
India
Shalby Hospital Limited
Ahmedabad, Gujarat, India, 380015
Vedanta Institute; Medical Sciences
Ahmedabad, India, 380009
Manipal Hospital
Bangalore, India, 560017
St.John's Medical College Hospital
Banglore, India, 560034
Arthritis Super Speciality Centre
Hubli, India, 580020
Care Institute of Medical Sciences
Hyderabad, India, 500034
Jasleen Hospital
Nagpur, India, 440010
Israel
Barzilai Medical Center
Ashkelon, Israel, 78278
Assaf Harofeh Medical Center
Beer Yaacov, Israel, 6093000
The Lady Davis Carmel Medical Center
Haifa, Israel, 34362
Chaim Sheba Medical Center; Rheumatology
Ramat Gan, Israel, 5262000
Tel-Aviv Sourasky Medical Center
Tel Aviv, Israel, 64239
Italy
Azienda Ospedaliera A. Cardarelli
Napoli, Campania, Italy, 80131
Ospedale San Giovanni Bosco; Divisione di Reumatologia
Napoli, Campania, Italy, 80144
Fondazione Salvatore Maugeri IRCCS; Istituto Scientifico di Riabilitazione di Telese
Telese Terme, Campania, Italy, 82037
Ospedale La Colletta
Arenzano, Liguria, Italy, 16011
Azienda Ospedaliero Universitaria San Martino
Genova, Liguria, Italy, 16132
Ospedali Riuniti di Bergamo
Bergamo, Lombardia, Italy, 24128
Asst Grande Ospedale Metropolitano Niguarda; Dipartimento Di Ematologia Ed Oncologia
Milano, Lombardia, Italy, 20162
Ospedale Di Circolo E Fondazione Macchi
Varese, Lombardia, Italy, 21100
Presidio Ospedaliero Vittorio Emanuele
Catania, Sicilia, Italy, 95124
Azienda Ospedaliera Universitaria Careggi
Firenze, Toscana, Italy, 50141
Ospedale Misericordia e Dolce
Prato, Toscana, Italy, 59100
Latvia
L.Krumina GP practice
Bauska, Latvia, 3901
Daugavpils Regional Hospital
Daugavpils, Latvia, 5417
D.Saulite-Kandevica Private Practice
Liepaja, Latvia, 3400
Clinic ORTO
Riga, Latvia, 1005
Private Practice EHOKG
Riga, Latvia, 1021
Riga East Clinical University Hospital; Clinic Gailezers
Riga, Latvia, LV 1002
P. Stradins Clinical University Hospital
Riga, Latvia, LV-1002
Lithuania
Alytus Regional S. Kudirkos Hospital, Public Institution
Alytus, Lithuania, 62114
Klaipeda Seamen's Hospital, Public Institution
Klaipeda, Lithuania, 92288
Klaipeda University Hospital; Public Institution
Klaipeda, Lithuania, 92288
Siauliai Republican Hospital Public Institution
Siauliai, Lithuania, 76231
Vilnius District Central Outpatient Clinic, Public Institution
Vilnius, Lithuania, 06122
Malaysia
Hospital Raja Permaisuri Bainun
Ipoh, Perak, Malaysia, 30990
Hospital Selayang
Kuala Lumpur, Malaysia, 68100
Hospital Umum Sarawak
Kuching, Malaysia, 93586
Hospital Pulau Pinang
Penang, Malaysia, 10990
Sunway Medical Centre
Selangor, Malaysia, 46150
Sime Darby Medical Centre
Selangor, Malaysia, 47500
Mexico
Centro de Investigacion del Noroeste SC
Tijuana, Baja California, Mexico, 22010
Centro de Investigación de Tratamientos Innovadores de Sinaloa (CITI)
Culiacán Rosales, Sinaloa, Mexico, 80000
Unidad de Atencion Medica e Investigacion en Salud S.C.
Mérida, Yucatan, Mexico, 97000
Hospital Christus Muguerza del Parque; Reumatologia
Chihuahua, Mexico, 31000
Hospital CIMA Chihuahua; Reumatologia
Chihuahua, Mexico, 31238
Hospital Privado San Jose de Ciudad Obregon SA de CV
Ciudad Obregon, Mexico, 85000
Private Practice Dr. Cortes
Cuernavaca, Mexico, 62270
RM pharma specialist SA de CV
Delegacion Benito Juarez, Mexico, 03100
Mentrials S.A. de C.V
Distrito Federal, Mexico, 06600
Centro de Investigacion y Atencion Integral Durango CIAID
Durango, Mexico, 34080
Mundo Fisico
Guadalajara, Mexico, 44500
Clinica Hospital Angeles Chapalita
Guadalajara, Mexico, 45040
Centro de Investigacion en Enfermedades Reumaticas y Osteoporosis
Mexicali, Mexico, 21100
Inst. Mexicano de Investigacion Clinica
Mexico City, Mexico, 06700
Instituto Nacional de Cardiologia Ignacio Chavez
Mexico City, Mexico, 14080
Hospital Mocel
Mexico Df, Mexico, 11850
Mexico Centre for Clinical Research
Mexico, Mexico, 03100
Comite Mexicano Para la Prevencion de Osteoporosis AC
Mexico, Mexico, 06100
Cliditer SA de CV
Miexico City, Mexico, 06700
Hospital Universitario de Saltillo
Saltillo, Mexico, 25000
Hospital Central Dr. Ignacio Morones Prieto
San Luis Potosi S.L.P., Mexico, 78240
Centro de Alta Especialidad en Reumatología e Investigación del Potosí, S.C.
San Luis Potosí, Mexico, 78200
Unidad de Enfermedades Reumaticas y Cronicodegenerativas
Torreon, Mexico, 27000
Netherlands
Jan Van Breemen Instituut
Amsterdam, Netherlands, 1056 AB
Albert Schweitzer Ziekenhuis ; Dordwijk
Dordrecht, Netherlands, 3318AT
Franciscus Ziekenhuis
Roosendaal, Netherlands, 4708 AE
Vlietland Hospital
Schiedam, Netherlands, 3118 JH
Philippines
Cebu Doctors' University Hospital- North General Hospital
Cebu City, Philippines, 6000
Chong Hua Hospital, Cebu City
Cebu City, Philippines, 6000
St. Paul Hospital; Arthritis Center
Iloilo City, Philippines, 5000
Mary Mediatrix Medical Center
Lipa City, Philippines, 4217
Makati Medical Center
Makati City, Philippines, 1229
Poland
Szpital Uniwersytecki; nr 2 im. Dr J. Biziela
Bydgoszcz, Poland, 85-168
Wojewodzki Szpital Zespolony w Elblagu
Elblag, Poland, 82-300
Szpital Specjalistyczny Im J. Dietla Malopolskie Centrum Reumat; Oddzial Rumatologii
Krakow, Poland, 30-119
Szpital Specjalistyczny im. J. Dietla
Krakow, Poland, 31-121
NZOZ REUMED Sp. z o.o.
Lublin, Poland, 20-607
Lecznica MAK-MED NZOZ
Nadarzyn, Poland, 05-830
SP Szpital Kliniczny nr 1 Pomorskiej Akademii Medycznej im. prof. Tadeusza Sokolowskiego
Szczecin, Poland, 71-252
Slaski Szpital Reumatologiczno; Rehabilitacyjny; Iii Oddzial Reumatologiczny
Ustron, Poland, 43-450
Rheuma Medicus Zaklad Opieki Zdrowotnej
Warszawa, Poland, 02-118
ARS Rheumatica Sp.z o. o
Warszawa, Poland, 02-653
Akademicki Szpital Kliniczny im. Jana Mikulicza Radeckiego
Wroclaw, Poland, 50-556
Romania
Spitalul Clinic Judetean de Urgenta Brasov
Brasov, Romania, 500365
Spitalul Clinic Dr. I Cantacuzino
Bucharest, Romania, 020475
Spitalul Clinic Sf. Maria; Dept Interna si Reumatologie
Bucuresti, Romania, 011172
Centrul de Boli Reumatismale Dr. Ioan Stoia
Bucuresti, Romania, 020983
Medex SRL
Cluj-Napoca, Romania, 400130
Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Clinica de Medicina Muncii
Cluj-Napoca, Romania, 400349
CMI Dr.Ciornohuz Adriana
Iasi, Romania, 700127
Spitalul Clinic de Recuperare Iasi
Iasi, Romania, 700656
Spitalul Municipal Ploiesti
Ploiesti, Romania, 100337
Spitalul Clinic Colentina
Sector 2, Romania, 020125
Spitalul Judetean de Urgenta Targoviste
Targoviste, Romania, 130083
Mediab SRL
Targu Mures, Romania, 540142
Spitalul Clinic Municipal de Urgenta Timisoara
Timisoara, Romania, 300194
Russian Federation
State institution of health care - Territorial Clinical Hospital
Barnaul, Russian Federation, 656024
SEI of HPE "Altay State Medical University of Roszdrav"
Barnaul, Russian Federation, 656038
Scientific and research medical complex Your Health
Kazan, Russian Federation, 420097
SIH Kemerovo Regional Clinical Hospital
Kemerovo, Russian Federation, 650002
City Hospital No.4
Moscow, Russian Federation, 115093
Scient Res Inst Rheumat RAMS
Moscow, Russian Federation, 115522
Moscow State Medical Stomatological University
Moscow, Russian Federation, 121374
Head Clinical Hospital of Internal Affair Ministry of Russia
Moscow, Russian Federation, 123060
MHI City Clinical Hospital#19
Novosibirsk, Russian Federation, 630068
FSBI Scientific Research Institute of Clinical Immunology of SB of RAMS
Novosibirsk, Russian Federation, 630099
Ryazan Regional Clinincal Cardiology Dispensary
Ryazan, Russian Federation, 390026
State institution of healthcare "Regional hospital for war veterans"
Saratov, Russian Federation, 410002
Leningradskaya Regional Clinical Hospital; Rheumatology Dept
St Petersburg, Russian Federation, 194291
Stavropol State Medical Academy
Stavropol, Russian Federation, 355017
Tomsk Regional Clinical Hospital
Tomsk, Russian Federation, 634063
Voronezh Regional Clinical Hospital #1
Voronezh, Russian Federation, 394066
MCHI Medical Sanitary Unit of Yaroslavl Diesel Apparatus Plant
Yaroslavl, Russian Federation, 150007
Serbia
Institute of Rheumatology
Belgrade, Serbia, 11000
Military Medical Academy
Belgrade, Serbia, 11040
Clinical Center Bezanijska Kosa
Belgrade, Serbia, 11070
Institute of Rheumatology and Cardiovascular Diseases; Rheumatology
Niska Banja, Serbia, 18205
South Africa
Groote Schuur Hospital; Rheumatology Unit
Cape Town, South Africa, 7925
Chris Hani Baragwanath Hospital; Rheumatology Department
Diepkloof, South Africa, 1862
Charlotte Maxeke Academic Hospital
Johannesburg, South Africa, 2193
University of Pretoria; Clinical Trial Unit
Pretoria, South Africa, 0002
Spain
Hospital de Merida ;Servicio de Reumatologia
Merida, Badajoz, Spain, 06800
Corporacio Sanitaria Parc Tauli
Sabadell, Barcelona, Spain, 08208
Hospital Sierrallana
Torrelavega, Cantabria, Spain, 39300
Hospital Clinico Universitario de Santiago
Santiago de Compostela, La Coruña, Spain, 15706
Hospital Infanta Sofia; Servicio de Reumatologia
San Sebastian de los Reyes, Madrid, Spain, 28702
Hospital Regional Universitario Carlos Haya
Málaga, Malaga, Spain, 29009
Hospital Universitario Virgen Macarena
Seville, Sevilla, Spain, 41071
Hospital Universitario de Canarias
S. Cristobal de la Laguna, Tenerife, Spain, 38320
Hospital de Cruces; Servicio de Reumatologia
Barakaldo, Vizcaya, Spain, 48903
Hospital Universitario Basurto
Bilbao, Vizcaya, Spain, 48013
Hospital General de Castellon; Servicio de Reumatologia
Castellon, Spain, 12004
Hospital Gregorio Marañon
Madrid, Spain, 28007
Turkey
Akdeniz Univesity Medical Faculty
Antalya, Turkey, 07058
Trakya University Medical Faculty
Edirne, Turkey, 22030
Ataturk University Med Faculty
Erzurum, Turkey, 25050
Karadeniz Tecnical Uni. Med. Fac.
Trabzon, Turkey, 61100
United Kingdom
Selly Oak Hospital; Rheumatology Dept
Birmingham, United Kingdom, B29 6JD
Addenbrooke's NHS Trust
Cambridge, United Kingdom, CB2 0QQ
Cannock Chase Hospital; Rheumatology
Cannock, United Kingdom, WS11 5XY
Russells Hall Hospital; Rheumatology Department
Dudley, United Kingdom, DY1 2HQ
Leicester Royal Infirmary NHS Trust
Leicester, United Kingdom, LE1 5WW
Royal London Hospital Outpatients Department
London, United Kingdom, E1 1BB
Whipps Cross Hospital; Rheumatology Dept
London, United Kingdom, E11 1NR
King'S College Hospital
London, United Kingdom, SE5 9RS
Royal Victoria Infirmary
Newcastle upon Tyne, United Kingdom, NE1 4LP
Salford Royal NHS Foundation Trust
Salford, United Kingdom, M6 8HD
Southampton General Hospital; Rheumatology
Southampton, United Kingdom, SO16 6YD
Southend Hospital; Rheumatology Department
Westcliffe-on-sea, United Kingdom, SS0 0RY
Wrightington Hospital
Wrightington, United Kingdom, WN6 9EP
Sponsors and Collaborators
Hoffmann-La Roche
Investigators
Study Director: Clinical Trials Hoffmann-La Roche
  More Information

Responsible Party: Hoffmann-La Roche
ClinicalTrials.gov Identifier: NCT01331837     History of Changes
Other Study ID Numbers: WA25204
2010-020065-24 ( EudraCT Number )
First Submitted: April 7, 2011
First Posted: April 8, 2011
Results First Submitted: March 24, 2017
Results First Posted: July 13, 2017
Last Update Posted: July 13, 2017
Last Verified: June 2017

Additional relevant MeSH terms:
Arthritis
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Etanercept
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Gastrointestinal Agents
Immunosuppressive Agents
Immunologic Factors