Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events) (CANTOS)

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier:
NCT01327846
First received: March 29, 2011
Last updated: May 19, 2015
Last verified: May 2015
  Purpose

Main Study (CACZ885M2301) The purpose of this trial is to test the hypothesis that canakinumab treatment of patients with MI at least one month prior to study entry and elevated hsCRP will prevent recurrent cardiovascular events.

Sub-study 1 (CACZ885M2301S1) The purpose of this sub-study is to evaluate the effect of quarterly subcutaneous canakinumab treatment for 24 months comparted with placebo on the carotid plaque burden measured by integrated vascular MRI in patients enrolled in the CACZ885M2301 study (CANTOS).

Sub-study 2 (CACZ885M2301S2) The purpose of this CANTOS sub-study is to determine whether, in patients with type 2 diabetes participating in the CANTOS main study, canakinumab compared to placebo, on top of standard of care increases insulin secretion and insulin sensitivity.


Condition Intervention Phase
Atherosclerosis
Drug: Canakinumab
Drug: Placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized, Double-blind, Placebo-controlled, Event Driven Trial of Quarterly Subcutaneous Canakinumab in the Prevention of Recurrent Cardiovascular Events Among Stable Post-Myocardial Infarction Patients With Elevated hsCRP Including Substudies to Evaluate the Effect of Canakinumab on Carotid Atherosclerosis, and on Glucose Control Following OGTT in T2DM

Resource links provided by NLM:


Further study details as provided by Novartis:

Primary Outcome Measures:
  • Main:Time to first occurrence of major adverse cardiovascular event, which is a composite of CV death, non-fatal MI, and stroke. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Substudy 1; Change from baseline in carotid plaque burden in the bifurcation region of the index carotid artery [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Substudy 2; Change from baseline of the insulin secretion rate (ISR) relative to glucose 0-30 min defined as Φ30 = AUCISR 0-30 / AUCGluc 0-30 averaged across the yearly visits. [ Time Frame: 36 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Main:Time to first occurrence of the composite cardiovascular endpoint consisting of cardiovascular death, non-fatal MI, stroke and hospitalization for unstable angina requiring unplanned revascularization. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Main:Time to new onset type 2 diabetes among patients with pre-diabetes at randomization. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Main:Time to first occurrence of non-fatal MI, stroke and all-cause mortality composite. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Main: Time to all-cause mortality. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Substudy 1; Change from baseline of the total vessel wall area at Month 3 of the index carotid artery. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Substudy 1; Mean total vessel wall area across the left and right carotid artery at Month 3 and Month 24. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Substudy 1; Change from baseline in corresponding total vessel wall area in the left and right carotid arteries. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Substudy 1; The existence of a baseline total vessel wall area by treatment interaction as well as the consistency of the treatment effect across subgroups. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Substudy 2; Change from baseline in insulin sensitivity index. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Substudy 2; Change from baseline in OGTT stimulated area under curve (AUC) 0-120 min of glucose concentration, insulin concentration, pro-insulin concentration, and insulin concentration/glucose concentration ratio. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Substudy 2; Change from baseline in fasting pro-insulin concentration /insulin concentration ratio. [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Substudy 2; Change from baseline in OGTT stimulated area under the curve (AUC) 0-120 min of C-peptide concentration. [ Time Frame: 36 months ] [ Designated as safety issue: No ]

Enrollment: 10120
Study Start Date: April 2011
Estimated Study Completion Date: April 2017
Estimated Primary Completion Date: April 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Canakinumab 50 mg
Description: Canakinumab 50 mg quarterly subcutaneous + standard of care therapy.
Drug: Canakinumab
Experimental: Canakinumab Dose 150 mg
Description: Canakinumab 150 mg quarterly subcutaneous + standard of care therapy.
Drug: Canakinumab
Experimental: Canakinumab Dose 300 mg
Description: Canakinumab 300 mg quarterly subcutaneous + standard of care therapy.
Drug: Canakinumab
Placebo Comparator: Placebo
Description: Matching placebo quarterly subcutaneous + standard of care therapy.
Drug: Placebo

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Main Study Inclusion Criteria:

  • Written informed consent
  • Male, or Female of non-child-bearing potential
  • Age ≥ 18 years.
  • Spontaneous MI at least 30 days before randomization. hsCRP ≥ 2 mg/L

Substudy 1 Inclusion:

  • All Inclusion from Main Study
  • Acquisition of evaluable baseline MRI images of bilateral carotid arteries by the imaging core laboratory

Substudy 2 Inclusion:

  • All inclusion from Main Study
  • T2D at baseline per Main protocol criteria and be on a stable anti-hyperglycemic medication for at least 4 weeks prior to the baseline OGTT test
  • Willing to have the OGTT assessment started before 10 am

Main Study Exclusion Criteria:

  • Pregnant or nursing (lactating) women
  • Women of child-bearing potential
  • Any of the following concomitant diseases
  • Planned coronary revascularization (PCI or CABG)
  • Major non-cardiac surgical or endoscopic procedure within past 6 months
  • Multi-vessel CABG surgery within the past 3 years
  • Symptomatic patients with Class IV heart failure (HF) (New York Heart Association [NYHA].
  • Uncontrolled hypertension
  • Uncontrolled diabetes
  • History or evidence of active tuberculosis (TB) infection Substudy 1 Exclusion
  • All Main exclusion
  • Patients with prior history of carotid angioplasty, stenting, or carotid atherectomy
  • Patients with contraindications to MRI examination (brain aneurysm clip, implanted neural stimulator, implanted cardiac pacemaker, pacemaker wires or defibrillator, prosthetic heart valves, cochlear implant, ocular foreign body or other implanted body, tattoos, implanted insulin pump, metal shrapnel or bullet)
  • Patients prone to claustrophobia or known anxiety disorders
  • BMI > 40 kg/m2 Substudy 2 Exclusion
  • This sub-study does not have any additional exclusion criteria. Other protocol-defined inclusion/exclusion criteria may apply
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01327846

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Gonzales, Texas, United States, 78629
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Greenville, Texas, United States, 75401
Novartis Investigative Site
Houston, Texas, United States, 77081
Novartis Investigative Site
Houston, Texas, United States, 77030
Novartis Investigative Site
Houston, Texas, United States, 77055
Novartis Investigative Site
Houston, Texas, United States, 77070
Novartis Investigative Site
Houston, Texas, United States, 77025
Novartis Investigative Site
Irving, Texas, United States, 75039
Novartis Investigative Site
Lake Jackson, Texas, United States, 77566
Novartis Investigative Site
Leander, Texas, United States, 78641
Novartis Investigative Site
Livingston, Texas, United States, 77351
Novartis Investigative Site
Lufkin, Texas, United States, 75904
Novartis Investigative Site
Marshall, Texas, United States, 75670
Novartis Investigative Site
McAllen, Texas, United States, 78501
Novartis Investigative Site
McKinney, Texas, United States, 75069
Novartis Investigative Site
Odessa, Texas, United States, 79761
Novartis Investigative Site
Pasadena, Texas, United States, 77504
Novartis Investigative Site
Plano, Texas, United States, 75093
Novartis Investigative Site
San Antonio, Texas, United States, 78229-4801
Novartis Investigative Site
San Antonio, Texas, United States, 78229-3900
Novartis Investigative Site
San Antonio, Texas, United States, 78234
Novartis Investigative Site
San Antonio, Texas, United States, 78229
Novartis Investigative Site
San Antonio, Texas, United States, 78212
Novartis Investigative Site
San Antonio, Texas, United States, 78238-7676
Novartis Investigative Site
San Antonio, Texas, United States, 78258
Novartis Investigative Site
Temple, Texas, United States, 76508
Novartis Investigative Site
Tomball, Texas, United States, 77375
Novartis Investigative Site
Waco, Texas, United States, 76710
Novartis Investigative Site
Webster, Texas, United States, 77598
United States, Utah
Novartis Investigative Site
Bountiful, Utah, United States, 84010
Novartis Investigative Site
Layton, Utah, United States, 84041
Novartis Investigative Site
Salt Lake City, Utah, United States, 84102
Novartis Investigative Site
Salt Lake City, Utah, United States, 84107
Novartis Investigative Site
Salt Lake City, Utah, United States, 84124
United States, Virginia
Novartis Investigative Site
Burke, Virginia, United States, 22015
Novartis Investigative Site
Danville, Virginia, United States, 24541
Novartis Investigative Site
Ettrick, Virginia, United States, 23803
Novartis Investigative Site
Richmond, Virginia, United States, 23249
Novartis Investigative Site
Richmond, Virginia, United States, 23298
United States, Washington
Novartis Investigative Site
Port Orchard, Washington, United States, 98366
Novartis Investigative Site
Renton, Washington, United States, 98055
Novartis Investigative Site
Seattle, Washington, United States, 98103
Novartis Investigative Site
Seattle, Washington, United States, 98104
Novartis Investigative Site
Tacoma, Washington, United States, 98405
United States, Wisconsin
Novartis Investigative Site
Madison, Wisconsin, United States, 53713
Argentina
Novartis Investigative Site
Bahía Blanca, Buenos Aires, Argentina, B8000AAT
Novartis Investigative Site
Caba, Buenos Aires, Argentina, 1428
Novartis Investigative Site
Caba, Buenos Aires, Argentina, C1056ABJ
Novartis Investigative Site
Caba, Buenos Aires, Argentina, C1440AAD
Novartis Investigative Site
Caba, Buenos Aires, Argentina, C1425AGC
Novartis Investigative Site
Caba, Buenos Aires, Argentina, C1425BWO
Novartis Investigative Site
Caba, Buenos Aires, Argentina, C1221ADC
Novartis Investigative Site
Mar del Plata, Buenos Aires, Argentina, 7600
Novartis Investigative Site
Mar del Plata, Buenos Aires, Argentina, B7600
Novartis Investigative Site
Quilmes, Buenos Aires, Argentina, B1878GEG
Novartis Investigative Site
Quilmes, Buenos Aires, Argentina, B1878DVB
Novartis Investigative Site
Ramos Mejia, Buenos Aires, Argentina, B1704ETD
Novartis Investigative Site
San Isidro, Buenos Aires, Argentina, B1642DCD
Novartis Investigative Site
San Nicolas, Buenos Aires, Argentina, B2900DMH
Novartis Investigative Site
Zarate, Buenos Aires, Argentina, 2800
Novartis Investigative Site
Caba, Capital Federal, Argentina, C1179AAB
Novartis Investigative Site
Caba, Capital Federal, Argentina, C1425FVH
Novartis Investigative Site
San Salvador de Jujuy, Jujuy, Argentina, Y4600ABF
Novartis Investigative Site
Posadas, Misiones, Argentina, N3300AHX
Novartis Investigative Site
Cipolletti, Rio Negro, Argentina, 8324
Novartis Investigative Site
Tucuman, San Miguel de Tucuman, Argentina, T4000ICL
Novartis Investigative Site
Rosario, Santa Fe, Argentina, S2000CXH
Novartis Investigative Site
Rosario, Santa Fe, Argentina, S2000DSV
Novartis Investigative Site
Rosario, Santa Fe, Argentina, S200CXP
Novartis Investigative Site
San Miguel de Tucuman, Tucuman, Argentina, T4000IFL
Novartis Investigative Site
San Miguel de Tucuman, Tucuman, Argentina, T4000IIH
Novartis Investigative Site
San Miguel de Tucuman, Tucuman, Argentina, T4000EBR
Novartis Investigative Site
Caba, Argentina, C1119ACN
Novartis Investigative Site
Cordoba, Argentina, X5003DCE
Novartis Investigative Site
Cordoba, Argentina, X5000AAX
Novartis Investigative Site
Cordoba, Argentina, X5000AAI
Novartis Investigative Site
Cordoba, Argentina, X5000AAW
Novartis Investigative Site
Cordoba, Argentina, X5000EPU
Novartis Investigative Site
Cordoba, Argentina, X5000JJS
Novartis Investigative Site
Cordoba, Argentina, 5000
Novartis Investigative Site
Cordoba, Argentina, X5003DCP
Novartis Investigative Site
Cordoba, Argentina, X5009BSN
Novartis Investigative Site
Cordoba, Argentina, X5022CPU
Novartis Investigative Site
Cordoba, Argentina, X5220XAO
Novartis Investigative Site
Corrientes, Argentina, W3400CBI
Novartis Investigative Site
Corrientes, Argentina, W3400CLH
Novartis Investigative Site
Corrientes, Argentina, W3400
Novartis Investigative Site
Corrientes, Argentina, W3410AVV
Novartis Investigative Site
Córdoba, Argentina, X5006IKK
Novartis Investigative Site
Formosa, Argentina, P3634XAR
Novartis Investigative Site
Formosa, Argentina, P3600
Novartis Investigative Site
Salta, Argentina, 4400
Novartis Investigative Site
San Luis, Argentina, D5702JRS
Novartis Investigative Site
Santa Fe, Argentina, S3000FWO
Novartis Investigative Site
Santa Fe, Argentina, S3000EPV
Novartis Investigative Site
Santa Fe, Argentina, S3000EOZ
Novartis Investigative Site
Santiago del Estero, Argentina, G4200AQK
Novartis Investigative Site
Tucuman, Argentina, T4000HXU
Australia, Australian Capital Territory
Novartis Investigative Site
Garran, Australian Capital Territory, Australia, 2606
Australia, New South Wales
Novartis Investigative Site
Gosford, New South Wales, Australia, 2250
Novartis Investigative Site
Kogarah, New South Wales, Australia, 2217
Novartis Investigative Site
Liverpool, New South Wales, Australia, 2170
Australia, Queensland
Novartis Investigative Site
Milton, Queensland, Australia, 4064
Novartis Investigative Site
Southport, Queensland, Australia, 4215
Australia, Tasmania
Novartis Investigative Site
Hobart, Tasmania, Australia, 7000
Australia, Victoria
Novartis Investigative Site
Bundoora, Victoria, Australia, 3083
Novartis Investigative Site
Geelong, Victoria, Australia, 3220
Australia, Western Australia
Novartis Investigative Site
Bateman, Western Australia, Australia, 6150
Novartis Investigative Site
Joondalup, Western Australia, Australia, 6027
Novartis Investigative Site
Perth, Western Australia, Australia, 6000
Austria
Novartis Investigative Site
Graz, Austria, A-8036
Novartis Investigative Site
Linz, Austria, 4010
Novartis Investigative Site
Linz, Austria, A-4010
Novartis Investigative Site
Salzburg, Austria, A-5020
Novartis Investigative Site
St. Stefan, Austria, 8511
Novartis Investigative Site
Vienna, Austria, 1030
Novartis Investigative Site
Wien, Austria, A-1090
Belgium
Novartis Investigative Site
Aalst, Belgium, 9300
Novartis Investigative Site
Bonheiden, Belgium, 2820
Novartis Investigative Site
Brasschaat, Belgium, 2930
Novartis Investigative Site
Brussel, Belgium, 1000
Novartis Investigative Site
De Pinte, Belgium, 9840
Novartis Investigative Site
Genk, Belgium, 3600
Novartis Investigative Site
Gent, Belgium, 9000
Novartis Investigative Site
Hasselt, Belgium, 3500
Novartis Investigative Site
Huy, Belgium, 4500
Novartis Investigative Site
Leuven, Belgium, 3000
Novartis Investigative Site
Mechelen, Belgium, 2800
Novartis Investigative Site
Ottignies, Belgium, 1340
Novartis Investigative Site
Tienen, Belgium, 3300
Brazil
Novartis Investigative Site
Salvador, BA, Brazil, 40050-410
Novartis Investigative Site
Salvador, BA, Brazil, 40140-110
Novartis Investigative Site
Fortaleza, CE, Brazil, 60430-370
Novartis Investigative Site
Brasilia, DF, Brazil, 70390-903
Novartis Investigative Site
Brasilia, DF, Brazil, 70658-700
Novartis Investigative Site
Goiania, GO, Brazil, 74605-020
Novartis Investigative Site
Goiania, GO, Brazil, 74223-130
Novartis Investigative Site
Belo Horizonte, MG, Brazil, 30130-060
Novartis Investigative Site
Belo Horizonte, MG, Brazil, 30150-221
Novartis Investigative Site
Uberlândia, MG, Brazil, 38405-320
Novartis Investigative Site
Uberlândia, MG, Brazil, 38400-368
Novartis Investigative Site
Campo Grande, MS, Brazil, 79080-190
Novartis Investigative Site
Belem, PA, Brazil, 66087-660
Novartis Investigative Site
Recife, PE, Brazil, 52051 - 38
Novartis Investigative Site
Curitiba, PR, Brazil, 80730-150
Novartis Investigative Site
Passo Fundo, RS, Brazil, 99010-080
Novartis Investigative Site
Pelotas, RS, Brazil, 96015-290
Novartis Investigative Site
Porto Alegre, RS, Brazil, 90560-030
Novartis Investigative Site
Porto Alegre, RS, Brazil, 90610-000
Novartis Investigative Site
Porto Alegre, RS, Brazil, 90880-480
Novartis Investigative Site
Porto Alegre, RS, Brazil, 91350-200
Novartis Investigative Site
Porto Alegre, RS, Brazil, 90620-001
Novartis Investigative Site
Blumenau, SC, Brazil, 89010-500
Novartis Investigative Site
Campinas, SP, Brazil, 13060-904
Novartis Investigative Site
Campinas, SP, Brazil, 13010-001
Novartis Investigative Site
Campinas, SP, Brazil, 13020-431
Novartis Investigative Site
Santo Andre, SP, Brazil, 09190-615
Novartis Investigative Site
Sao Jose do Rio Preto, SP, Brazil, 15090-000
Novartis Investigative Site
Sao Paulo, SP, Brazil, 01327-010
Novartis Investigative Site
São Paulo, SP, Brazil, 04023-900
Novartis Investigative Site
São Paulo, SP, Brazil, 05403-000
Novartis Investigative Site
Tatuí, SP, Brazil, 18270-170
Novartis Investigative Site
Votuporanga, SP, Brazil, 15500-003
Bulgaria
Novartis Investigative Site
Pazardzhik, Bulgaria, 4400
Novartis Investigative Site
Pleven, Bulgaria, 5800
Novartis Investigative Site
Plovdiv, Bulgaria, 4000
Novartis Investigative Site
Sofia, Bulgaria, 1431
Novartis Investigative Site
Sofia, Bulgaria, 1202
Novartis Investigative Site
Sofia, Bulgaria, 1233
Novartis Investigative Site
Sofia, Bulgaria, 1309
Novartis Investigative Site
Sofia, Bulgaria, 1000
Novartis Investigative Site
Sofia, Bulgaria, 1527
Novartis Investigative Site
Sofia, Bulgaria, 1606
Canada, British Columbia
Novartis Investigative Site
New Westminster, British Columbia, Canada, V3L 3W4
Novartis Investigative Site
Surrey, British Columbia, Canada, V3V 1N1
Novartis Investigative Site
Victoria, British Columbia, Canada, V8R4R2
Canada, Manitoba
Novartis Investigative Site
Winnipeg, Manitoba, Canada, R2V 4W3
Canada, Newfoundland and Labrador
Novartis Investigative Site
Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
Canada, Nova Scotia
Novartis Investigative Site
Halifax, Nova Scotia, Canada, B3H 2Y9
Canada, Ontario
Novartis Investigative Site
Cambridge, Ontario, Canada, N1R 6V6
Novartis Investigative Site
Etobicoke, Ontario, Canada, M9V 4B4
Novartis Investigative Site
Hamilton, Ontario, Canada, L8L 2X2
Novartis Investigative Site
Kitchener, Ontario, Canada, N2M 5N4
Novartis Investigative Site
Mississauga, Ontario, Canada, L5K 2L3
Novartis Investigative Site
Newmarket, Ontario, Canada, L3Y 2P7
Novartis Investigative Site
Newmarket, Ontario, Canada, L3Y 8C3
Novartis Investigative Site
Ottawa, Ontario, Canada, K1Y 4W7
Novartis Investigative Site
Peterborough, Ontario, Canada, K9J 0B2
Novartis Investigative Site
Scarborough, Ontario, Canada, M1P 2V5
Novartis Investigative Site
Toronto, Ontario, Canada, M9W 4L6
Novartis Investigative Site
Toronto, Ontario, Canada, M5B 1N9
Canada, Quebec
Novartis Investigative Site
Drummondville, Quebec, Canada, J2B 7T1
Novartis Investigative Site
Gatineau, Quebec, Canada, J8Y 6S8
Novartis Investigative Site
Granby, Quebec, Canada, J2G 1T7
Novartis Investigative Site
Joliette, Quebec, Canada, J6E 6J2
Novartis Investigative Site
Lachine, Quebec, Canada, H8S 2E4
Novartis Investigative Site
Laval, Quebec, Canada, H7M 3L9
Novartis Investigative Site
Longueuil, Quebec, Canada, J4M 2X1
Novartis Investigative Site
Loretteville, Quebec, Canada, G2B 5S1
Novartis Investigative Site
Lévis, Quebec, Canada, G6V 4Z5
Novartis Investigative Site
Montreal, Quebec, Canada, H4J 1C5
Novartis Investigative Site
Montreal, Quebec, Canada, H3G 1A4
Novartis Investigative Site
Québec, Quebec, Canada, G1G 3Y8
Novartis Investigative Site
Sainte-Foy, Quebec, Canada, G1V 4G5
Novartis Investigative Site
Sherbrooke, Quebec, Canada, J1G-2E8
Novartis Investigative Site
St-Jean-sur-Richelieu, Quebec, Canada, J3A 1C3
Novartis Investigative Site
Ste-Foy, Quebec, Canada, G1W 4R4
Novartis Investigative Site
Terrebonne, Quebec, Canada, J6V 2H2
Novartis Investigative Site
Thetford Mines, Quebec, Canada, G6G 2V4
Canada, Saskatchewan
Novartis Investigative Site
Saskatoon, Saskatchewan, Canada, S7H 5M3
Canada
Novartis Investigative Site
Quebec, Canada, G1V 4G2
China, Beijing
Novartis Investigative Site
Beijing, Beijing, China, 100730
China, Chongqing
Novartis Investigative Site
Chongqing, Chongqing, China, 400010
China, Fujian
Novartis Investigative Site
Fuzhou, Fujian, China
China, Guangdong
Novartis Investigative Site
Guangzhou, Guangdong, China, 510030
China, Guangxi
Novartis Investigative Site
Nanning, Guangxi, China, 530021
China, Hebei
Novartis Investigative Site
Shijiazhuang, Hebei, China, 050000
China, Heilongjiang
Novartis Investigative Site
Harbin, Heilongjiang, China, 150001
China, Hubei
Novartis Investigative Site
Wuhan, Hubei, China, 430022
Novartis Investigative Site
Wuhan, Hubei, China, 430060
China, Hunan
Novartis Investigative Site
Changsha, Hunan, China, 410003
China, Jiangsu
Novartis Investigative Site
Nanjing, Jiangsu, China, 210009
Novartis Investigative Site
Suzhou, Jiangsu, China, 215006
China, Jilin
Novartis Investigative Site
Changchun, Jilin, China, 130033
China, Liaoning
Novartis Investigative Site
Shenyang, Liaoning, China, 110016
Novartis Investigative Site
Shenyang, Liaoning, China, 110003
China, Shanghai
Novartis Investigative Site
Shanghai, Shanghai, China, 200120
Novartis Investigative Site
Shanghai, Shanghai, China
China, Shanxi
Novartis Investigative Site
Xi'an, Shanxi, China, 710061
Novartis Investigative Site
Xian, Shanxi, China, 710004
China, Tianjin
Novartis Investigative Site
Tianjin, Tianjin, China, 300121
China, Zhejiang
Novartis Investigative Site
Hangzhou, Zhejiang, China, 310013
Novartis Investigative Site
Hangzhou, Zhejiang, China, 310016
China
Novartis Investigative Site
Baotou, China, 014040
Novartis Investigative Site
Beijing, China, 100028
Novartis Investigative Site
Beijing, China, 100029
Novartis Investigative Site
Beijing, China, 100034
Novartis Investigative Site
Beijing, China, 100038
Novartis Investigative Site
Beijing, China, 100176
Novartis Investigative Site
Beijing, China
Novartis Investigative Site
Guang Zhou City, China, 510000
Novartis Investigative Site
Shanghai, China, 200032
Novartis Investigative Site
Shanghai, China, 200080
Novartis Investigative Site
Tianjin, China, 300142
Novartis Investigative Site
Tianjin, China, 30045
Colombia
Novartis Investigative Site
Barranquilla, Atlantico, Colombia
Novartis Investigative Site
Cartagena, Bolivar, Colombia
Novartis Investigative Site
Manizales, Caldas, Colombia, 1700
Novartis Investigative Site
Bucaramanga, Santander, Colombia
Novartis Investigative Site
Floridablanca, Santander, Colombia, 57-7
Novartis Investigative Site
Armenia, Colombia
Novartis Investigative Site
Baranquilla, Colombia
Novartis Investigative Site
Barranquilla, Colombia
Novartis Investigative Site
Bogotá, Colombia
Novartis Investigative Site
Cali, Colombia
Novartis Investigative Site
Cartegena, Colombia
Novartis Investigative Site
Florida Blanca, Colombia
Croatia
Novartis Investigative Site
Cakovec, Croatia, 40000
Novartis Investigative Site
Koprivnica, Croatia, 48000
Novartis Investigative Site
Krapinske Toplice, Croatia, 49217
Novartis Investigative Site
Krapinske toplice, Croatia, 49 217
Novartis Investigative Site
Opatija, Croatia, 51410
Novartis Investigative Site
Rijeka, Croatia, 51000
Novartis Investigative Site
Varazdin, Croatia, 42000
Novartis Investigative Site
Virovitica, Croatia, 33000
Novartis Investigative Site
Zagreb, Croatia, 10000
Czech Republic
Novartis Investigative Site
Most, CZE, Czech Republic, 434 01
Novartis Investigative Site
Praha 2, CZE, Czech Republic, 128 08
Novartis Investigative Site
Trutnov, CZE, Czech Republic, 46063
Novartis Investigative Site
Benesov, Czech Republic, 256 30
Novartis Investigative Site
Brandys nad Labem, Czech Republic, 250 01
Novartis Investigative Site
Brno-Bohunice, Czech Republic, 639 01
Novartis Investigative Site
Broumov, Czech Republic, 550 01
Novartis Investigative Site
Jablonec nad Nisou, Czech Republic, 466 01
Novartis Investigative Site
Kladno, Czech Republic, 272 80
Novartis Investigative Site
Kolin, Czech Republic, 280 20
Novartis Investigative Site
Liberec, Czech Republic, 460 05
Novartis Investigative Site
Louny, Czech Republic
Novartis Investigative Site
Marianske lazne, Czech Republic, 353 01
Novartis Investigative Site
Ostrava, Czech Republic, 70200
Novartis Investigative Site
Pardubice, Czech Republic, 530 02
Novartis Investigative Site
Plzen, Czech Republic, 301 00
Novartis Investigative Site
Prague 4 - Krc, Czech Republic, 14059
Novartis Investigative Site
Praha 11, Czech Republic, 148 00
Novartis Investigative Site
Praha 2, Czech Republic, 128 08
Novartis Investigative Site
Praha 9, Czech Republic
Novartis Investigative Site
Roznov pod Radhostem, Czech Republic, 756 61
Novartis Investigative Site
Semily, Czech Republic, 513 31
Novartis Investigative Site
Slany, Czech Republic, 274 01
Novartis Investigative Site
Svitavy, Czech Republic, 568 25
Novartis Investigative Site
Teplice, Czech Republic, 415 29
Novartis Investigative Site
Trebic, Czech Republic, 674 01
Novartis Investigative Site
Uherske Hradiste, Czech Republic, 68601
Novartis Investigative Site
Usti nad Labem, Czech Republic, 400 01
Novartis Investigative Site
Usti nad Orlici, Czech Republic, 562 18
Novartis Investigative Site
Vyskov, Czech Republic, 68001
Novartis Investigative Site
Znojmo, Czech Republic, 669 02
Estonia
Novartis Investigative Site
Parnu, Estonia, 80010
Novartis Investigative Site
Saku, Estonia, 75501
Novartis Investigative Site
Tallinn, Estonia, 10611
Novartis Investigative Site
Tallinn, Estonia, 13419
Novartis Investigative Site
Tallinn, Estonia, 13619
Novartis Investigative Site
Tallinn, Estonia, 10138
Novartis Investigative Site
Tartu, Estonia, 50410
Novartis Investigative Site
Viljandi county, Estonia, 71024
Novartis Investigative Site
Võru, Estonia, 65608
Germany
Novartis Investigative Site
Bad Krozingen, Germany, 79189
Novartis Investigative Site
Balve, Germany, 58802
Novartis Investigative Site
Berlin, Germany, 10629
Novartis Investigative Site
Berlin, Germany, 10367
Novartis Investigative Site
Berlin, Germany, 10789
Novartis Investigative Site
Berlin, Germany, 12627
Novartis Investigative Site
Berlin, Germany, 13055
Novartis Investigative Site
Berlin, Germany, 13125
Novartis Investigative Site
Berlin, Germany, 13353
Novartis Investigative Site
Bochum, Germany, 44787
Novartis Investigative Site
Borna, Germany, 04552
Novartis Investigative Site
Chemnitz, Germany, 09122
Novartis Investigative Site
Chemnitz, Germany, 09130
Novartis Investigative Site
Dillingen, Germany, 66763
Novartis Investigative Site
Dinslaken, Germany, 46535
Novartis Investigative Site
Dortmund, Germany, 44137
Novartis Investigative Site
Dresden, Germany, 01067
Novartis Investigative Site
Dresden, Germany, 01069
Novartis Investigative Site
Dresden, Germany, 01277
Novartis Investigative Site
Dresden, Germany, 01307
Novartis Investigative Site
Dresden, Germany, 01309
Novartis Investigative Site
Duisburg, Germany, 47137
Novartis Investigative Site
Düsseldorf, Germany, 40597
Novartis Investigative Site
Ebersbach, Germany, 02730
Novartis Investigative Site
Elsterwerda, Germany, 04910
Novartis Investigative Site
Erlangen, Germany, 91054
Novartis Investigative Site
Essen, Germany, 45355
Novartis Investigative Site
Essen, Germany, 45136
Novartis Investigative Site
Essen, Germany, 45276
Novartis Investigative Site
Falkensee, Germany, 14612
Novartis Investigative Site
Frankfurt, Germany, 60488
Novartis Investigative Site
Frankfurt, Germany, 60594
Novartis Investigative Site
Frankfurt am Main, Germany, 60596
Novartis Investigative Site
Freiburg, Germany, 79106
Novartis Investigative Site
Fulda, Germany, 36037
Novartis Investigative Site
Giengen, Germany, 89537
Novartis Investigative Site
Goerlitz, Germany, 02826
Novartis Investigative Site
Haag, Germany, 83527
Novartis Investigative Site
Halle/'Saale, Germany, 06120
Novartis Investigative Site
Hamburg, Germany, 20246
Novartis Investigative Site
Hamburg, Germany, 22041
Novartis Investigative Site
Hamburg, Germany, 22393
Novartis Investigative Site
Hamburg, Germany, 22765
Novartis Investigative Site
Hamburg, Germany, 22177
Novartis Investigative Site
Heidelberg, Germany, 69120
Novartis Investigative Site
Heilbronn, Germany, 74078
Novartis Investigative Site
Huy / OT Anderbeck, Germany, 38836
Novartis Investigative Site
Jerichow, Germany, 39319
Novartis Investigative Site
Kallstadt, Germany, 67169
Novartis Investigative Site
Kamp-Lintfort, Germany, 47475
Novartis Investigative Site
Kassel, Germany, 34127
Novartis Investigative Site
Kiel, Germany, 24119
Novartis Investigative Site
Koblenz, Germany, 56068
Novartis Investigative Site
Kuenzing, Germany, 94550
Novartis Investigative Site
Köln, Germany, 51605
Novartis Investigative Site
Leipzig, Germany, 04107
Novartis Investigative Site
Leipzig, Germany, 04103
Novartis Investigative Site
Ludwigshafen, Germany, 67063
Novartis Investigative Site
Lüneburg, Germany, 21339
Novartis Investigative Site
Magdeburg, Germany, 39112
Novartis Investigative Site
Mainz, Germany, 55116
Novartis Investigative Site
Mainz, Germany, 55131
Novartis Investigative Site
Mayen, Germany, 56727
Novartis Investigative Site
Meissen, Germany, 01662
Novartis Investigative Site
Meißen, Germany, 01662
Novartis Investigative Site
Muehldorf am Inn, Germany, 84453
Novartis Investigative Site
Muehlhausen, Germany, 99974
Novartis Investigative Site
Mühlheim, Germany, 45468
Novartis Investigative Site
Neuhofen, Germany, 67141
Novartis Investigative Site
Neunkirchen, Germany, 66539
Novartis Investigative Site
Northeim, Germany, 37154
Novartis Investigative Site
Nürnberg, Germany, 90402
Novartis Investigative Site
Oelde, Germany, 59303
Novartis Investigative Site
Oschatz, Germany, 04758
Novartis Investigative Site
Paderborn, Germany, 33098
Novartis Investigative Site
Potsdam, Germany, 14469
Novartis Investigative Site
Rednitzhembach, Germany, 91126
Novartis Investigative Site
Reinfeld, Germany, 23858
Novartis Investigative Site
Rostock, Germany, 06120
Novartis Investigative Site
Rüdersdorf, Germany, 15562
Novartis Investigative Site
Siegen, Germany, 57072
Novartis Investigative Site
Ulm, Germany, 89081
Novartis Investigative Site
Wolmirstedt, Germany, 39326
Greece
Novartis Investigative Site
Athens, GR, Greece, 106 76
Novartis Investigative Site
Athens, GR, Greece, 14233
Novartis Investigative Site
Magoula, GR, Greece, 190 18
Novartis Investigative Site
Thessaloniki, GR, Greece, 570 10
Novartis Investigative Site
Voula, GR, Greece, 166 73
Novartis Investigative Site
Athens, Greece, GR 11525
Novartis Investigative Site
Athens, Greece, GR 11527
Novartis Investigative Site
Chaidari, Greece, GR 12461
Novartis Investigative Site
Chalikida, Greece, GR 34100
Novartis Investigative Site
Heraklion, Greece, GR 71409
Novartis Investigative Site
Heraklion, Greece, GR 71100
Novartis Investigative Site
Patras, Greece, GR 26504
Novartis Investigative Site
Thessaloniki, Greece, GR 56429
Guatemala
Novartis Investigative Site
Guatemala City, Guatemala, 01001
Novartis Investigative Site
Guatemala City, Guatemala, 01009
Novartis Investigative Site
Guatemala City, Guatemala, 01010
Novartis Investigative Site
Guatemala City, Guatemala, 01011
Novartis Investigative Site
Guatemala City, Guatemala, 01015
Hungary
Novartis Investigative Site
Budapest, Hungary, 1134
Novartis Investigative Site
Budapest, Hungary, H-1115
Novartis Investigative Site
Budapest, Hungary, 1122
Novartis Investigative Site
Budapest, Hungary, 1125
Novartis Investigative Site
Budapest, Hungary, 1042
Novartis Investigative Site
Budapest, Hungary, 1145
Novartis Investigative Site
Budapest, Hungary, 1083
Novartis Investigative Site
Csongrad, Hungary, 6640
Novartis Investigative Site
Debrecen, Hungary, 4032
Novartis Investigative Site
Gyula, Hungary, 5700
Novartis Investigative Site
Kistarcsa, Hungary, 2143
Novartis Investigative Site
Komarom, Hungary, 2921
Novartis Investigative Site
Miskolc, Hungary, 3530
Novartis Investigative Site
Mosonmagyarovar, Hungary, 9200
Novartis Investigative Site
Nyiregyháza, Hungary, 4400
Novartis Investigative Site
Pecs, Hungary, 7623
Novartis Investigative Site
Szeged, Hungary, H-6720
Novartis Investigative Site
Szekesfehervar, Hungary, 8000
Novartis Investigative Site
Szentes, Hungary, 6600
Novartis Investigative Site
Zalaegerszeg, Hungary, 8900
Iceland
Novartis Investigative Site
Kopavogur, Iceland, 201
Novartis Investigative Site
Reykjavik, Iceland, IS-109
Novartis Investigative Site
Reykjavik, Iceland, IS-101
India
Novartis Investigative Site
Hyderabad, Andhra Pradesh, India, 500001
Novartis Investigative Site
Hyderabad, Andhra Pradesh, India
Novartis Investigative Site
Nampally, Andhra Pradesh, India, 500 001
Novartis Investigative Site
Nellore, Andhra Pradesh, India, 524 003
Novartis Investigative Site
Secunderabad, Andhra Pradesh, India, 500003
Novartis Investigative Site
Secunderabad, Andhra Pradesh, India, 500 003
Novartis Investigative Site
Tirupati, Andhra Pradesh, India, 517 5-7
Novartis Investigative Site
Vijayawada, Andhra Pradesh, India, 520002
Novartis Investigative Site
Vijayawada, Andhra Pradesh, India, 520 008
Novartis Investigative Site
Vishakhapatnam, Andhra Pradesh, India, 530 013
Novartis Investigative Site
Guntur, Andhrapradesh, India, 522001
Novartis Investigative Site
New Delhi, Delhi, India, 110060
Novartis Investigative Site
Ahmedabad, Gujarat, India, 382428
Novartis Investigative Site
Ahmedabad, Gujarat, India, 380 051
Novartis Investigative Site
Ahmedabad, Gujarat, India, 380006
Novartis Investigative Site
Surat, Gujarat, India, 395001
Novartis Investigative Site
Surat, Gujarat, India, 395007
Novartis Investigative Site
Vadodara, Gujarat, India, 390015
Novartis Investigative Site
Bangalore, Karnataka, India, 560 055
Novartis Investigative Site
Bengaluru, Karnataka, India, 560034
Novartis Investigative Site
Manipal, Karnataka, India, 576104
Novartis Investigative Site
Kochi, Kerala, India, 682 018
Novartis Investigative Site
Nagpur, Maharashtra, India, 400012
Novartis Investigative Site
Nagpur, Maharashtra, India, 440 010
Novartis Investigative Site
Nagpur, Maharashtra, India, 44000033
Novartis Investigative Site
Nagpur, Maharashtra, India, 440012
Novartis Investigative Site
Nashik, Maharashtra, India, 422 005
Novartis Investigative Site
Pune, Maharashtra, India, 411 005
Novartis Investigative Site
Pune, Maharashtra, India, 411005
Novartis Investigative Site
Pune, Maharashtra, India, 411004
Novartis Investigative Site
Ludhiana, Punjab, India, 141002
Novartis Investigative Site
Ludhiana, Punjab, India, 141012
Novartis Investigative Site
Ludhiana, Punjab, India, 141421
Novartis Investigative Site
Mohali, Punjab, India, 160 062
Novartis Investigative Site
Bikaner, Rajasthan, India, 334003
Novartis Investigative Site
Jaipur, Rajasthan, India, 302024
Novartis Investigative Site
Jaipur, Rajasthan, India, 302016
Novartis Investigative Site
Chennai, Tamil Nadu, India, 600081
Novartis Investigative Site
Coimbatore, Tamil Nadu, India, 641037
Novartis Investigative Site
Madurai, Tamil Nadu, India, 625107
Novartis Investigative Site
Coimbatore, Tamilnadu, India, 641 018
Novartis Investigative Site
Ghaziabad, Uttar Pradesh, India
Novartis Investigative Site
Lucknow, Uttar Pradesh, India, 226005
Novartis Investigative Site
Varanasi, Uttar Pradesh, India, 224105
Novartis Investigative Site
Ahmedabad, India, 380052
Novartis Investigative Site
Ahmedabad, India, 380025
Novartis Investigative Site
Hyderabad, India, 500 063
Novartis Investigative Site
Rajasthan, India, 324005
Italy
Novartis Investigative Site
Ancona, AN, Italy, 60128
Novartis Investigative Site
Fermo, AP, Italy, 63023
Novartis Investigative Site
Cortona, AR, Italy, 52044
Novartis Investigative Site
Bergamo, BG, Italy, 24128
Novartis Investigative Site
Treviglio, BG, Italy, 24047
Novartis Investigative Site
Brescia, BS, Italy, 25123
Novartis Investigative Site
Montichiari, BS, Italy, 25018
Novartis Investigative Site
Monserrato, CA, Italy, 09133
Novartis Investigative Site
Santa Maria Capua Vetere, CE, Italy, 81055
Novartis Investigative Site
Chieti, CH, Italy, 66100
Novartis Investigative Site
Catanzaro, CZ, Italy, 88100
Novartis Investigative Site
Cona, FE, Italy, 44100
Novartis Investigative Site
Foggia, FG, Italy, 71100
Novartis Investigative Site
Firenze, FI, Italy, 50134
Novartis Investigative Site
Pozzilli, IS, Italy, 86077
Novartis Investigative Site
Milano, MI, Italy, 20132
Novartis Investigative Site
Milano, MI, Italy, 20145
Novartis Investigative Site
Milano, MI, Italy, 20100
Novartis Investigative Site
Rozzano, MI, Italy, 20089
Novartis Investigative Site
Massa, MS, Italy, 54100
Novartis Investigative Site
Palermo, PA, Italy, 90129
Novartis Investigative Site
Piacenza, PC, Italy, 29100
Novartis Investigative Site
Pisa, PI, Italy, 56126
Novartis Investigative Site
Parma, PR, Italy, 43100
Novartis Investigative Site
Casorate Primo, PV, Italy, 27022
Novartis Investigative Site
Pavia, PV, Italy, 27100
Novartis Investigative Site
Roma, RM, Italy, 00161
Novartis Investigative Site
Roma, RM, Italy, 00168
Novartis Investigative Site
Roma, RM, Italy, 00189
Novartis Investigative Site
Sassari, SS, Italy, 07100
Novartis Investigative Site
Palmanova, UD, Italy, 33057
Novartis Investigative Site
San Daniele Del Friuli, UD, Italy, 33038
Novartis Investigative Site
Verona, VR, Italy, 37134
Novartis Investigative Site
Soriano Calabro, VV, Italy, 89831
Novartis Investigative Site
Napoli, Italy, 80131
Novartis Investigative Site
Novara, Italy, 28100
Novartis Investigative Site
Veruno, Italy, 28010
Japan
Novartis Investigative Site
Ichinomiya, Aichi, Japan, 491-8551
Novartis Investigative Site
Nagoya-city, Aichi, Japan, 453-8511
Novartis Investigative Site
Seto-city, Aichi, Japan, 489-8642
Novartis Investigative Site
Funabashi, Chiba, Japan, 273-8588
Novartis Investigative Site
Matsudo-city, Chiba, Japan, 270-2251
Novartis Investigative Site
Matsudo-city, Chiba, Japan, 271-0077
Novartis Investigative Site
Kasuga, Fukuoka, Japan, 816-0864
Novartis Investigative Site
Kurume-city, Fukuoka, Japan, 830-8577
Novartis Investigative Site
Onga-gun, Fukuoka, Japan, 807-0051
Novartis Investigative Site
Yukuhashi, Fukuoka, Japan, 824-0026
Novartis Investigative Site
Ogaki-city, Gifu, Japan, 503-8502
Novartis Investigative Site
Fujioka-city, Gunma, Japan, 375-0015
Novartis Investigative Site
Takasaki-city, Gunma, Japan, 370-0036
Novartis Investigative Site
Hatsukaichi-city, Hiroshima, Japan, 738-8503
Novartis Investigative Site
Amagasaki-city, Hyogo, Japan, 660-0828
Novartis Investigative Site
Amagasaki-city, Hyogo, Japan, 661-0976
Novartis Investigative Site
Takarazuka-city, Hyogo, Japan, 665-0022
Novartis Investigative Site
Higashiibaraki-gun, Ibaraki, Japan, 311-3193
Novartis Investigative Site
Hitachi-city, Ibaraki, Japan, 317-0077
Novartis Investigative Site
Sakaide-city, Kagawa, Japan, 762-0007
Novartis Investigative Site
Takamatsu-city, Kagawa, Japan, 760-8557
Novartis Investigative Site
Yokohama-city, Kanagawa, Japan, 234-8503
Novartis Investigative Site
Kumamoto City, Kumamoto, Japan, 860-8556
Novartis Investigative Site
Kyoto-city, Kyoto, Japan, 607-8062
Novartis Investigative Site
Sendai-city, Miyagi, Japan, 980-8574
Novartis Investigative Site
Sendai-city, Miyagi, Japan, 983-8520
Novartis Investigative Site
Hirakata-City, Osaka, Japan, 573-0153
Novartis Investigative Site
Osaka-city, Osaka, Japan, 543-0035
Novartis Investigative Site
Osaka-city, Osaka, Japan, 543-8555
Novartis Investigative Site
Osaka-city, Osaka, Japan, 558-8558
Novartis Investigative Site
Takatsuki, Osaka, Japan, 569-0852
Novartis Investigative Site
Sayama-city, Saitama, Japan, 350-1305
Novartis Investigative Site
Tokorozawa, Saitama, Japan, 359-1142
Novartis Investigative Site
Kusatsu-city, Shiga, Japan, 525-0014
Novartis Investigative Site
Komatsushima-city, Tokushima, Japan, 773-8502
Novartis Investigative Site
Bunkyo-ku, Tokyo, Japan, 113-8603
Novartis Investigative Site
Chiyoda-ku, Tokyo, Japan, 101-8309
Novartis Investigative Site
Chiyoda-ku, Tokyo, Japan, 101-8643
Novartis Investigative Site
Fuchu-city, Tokyo, Japan, 183-0003
Novartis Investigative Site
Itabashi-ku, Tokyo, Japan, 173-8610
Novartis Investigative Site
Nagano, Japan, 380-0814
Korea, Republic of
Novartis Investigative Site
Wonju, Gangwon-Do, Korea, Republic of, 220-701
Novartis Investigative Site
Suwon, Gyeonggi-do, Korea, Republic of, 443-721
Novartis Investigative Site
Uijeongbu-Si, Gyeonggi-do, Korea, Republic of, 480-717
Novartis Investigative Site
Seoul, Korea, Korea, Republic of, 137-701
Novartis Investigative Site
Busan, Korea, Republic of, 612-896
Novartis Investigative Site
Busan, Korea, Republic of, 602-812
Novartis Investigative Site
Busan, Korea, Republic of, 602-739
Novartis Investigative Site
Daegu, Korea, Republic of, 705-703
Novartis Investigative Site
Daegu, Korea, Republic of, 705-718
Novartis Investigative Site
Daejeon, Korea, Republic of, 301-747
Novartis Investigative Site
Gwangju, Korea, Republic of, 501-757
Novartis Investigative Site
Seoul, Korea, Republic of, 120-752
Novartis Investigative Site
Seoul, Korea, Republic of, 152-703
Latvia
Novartis Investigative Site
Liepaja, LV, Latvia, LV-3414
Novartis Investigative Site
Riga, LV, Latvia, LV-1005
Novartis Investigative Site
Ventspils, LV, Latvia, LV-3601
Novartis Investigative Site
Daugavplis, Latvia, LV-5417
Novartis Investigative Site
Riga, Latvia, 1012
Novartis Investigative Site
Valmiera, Latvia, 4201
Lithuania
Novartis Investigative Site
Alytus, Lithuania, LT-62381
Novartis Investigative Site
Kaunas, Lithuania, LT-49449
Novartis Investigative Site
Kaunas, Lithuania, LT-44320
Novartis Investigative Site
Kaunas, Lithuania, LT-49387
Novartis Investigative Site
Kaunas, Lithuania, 50009
Novartis Investigative Site
Kedainiai, Lithuania, LT-57164
Novartis Investigative Site
Klaipeda, Lithuania, LT-92288
Novartis Investigative Site
Panevezys, Lithuania, LT-37460
Novartis Investigative Site
Siauliai, Lithuania, LT-76231
Novartis Investigative Site
Vilnius, Lithuania, LT-08661
Mexico
Novartis Investigative Site
Guadalajara, Jalisco, Mexico, 44210
Novartis Investigative Site
Guadalajara, Jalisco, Mexico, 44280
Novartis Investigative Site
Culiacan, Sinaloa, Mexico, 80020
Novartis Investigative Site
Aguascalientes, Mexico, 20230
Novartis Investigative Site
Querétaro, Mexico, 76000
Novartis Investigative Site
San Luis Potosi, Mexico, 78200
Novartis Investigative Site
San Luis Potosí, Mexico, 78240
Netherlands
Novartis Investigative Site
Sneek, The Netherlands, Netherlands, 8601 ZR
Novartis Investigative Site
Alkmaar, Netherlands, 1815 JD
Novartis Investigative Site
Amersfoort, Netherlands, 3813 TZ
Novartis Investigative Site
Amstelveen, Netherlands, 1186 AM
Novartis Investigative Site
Amsterdam, Netherlands, 1090 HM
Novartis Investigative Site
Amsterdam, Netherlands, 1105 AZ
Novartis Investigative Site
Apeldoorn, Netherlands, 7334 DZ
Novartis Investigative Site
Breda, Netherlands, 4811SW
Novartis Investigative Site
Deventer, Netherlands, 7416 SE
Novartis Investigative Site
Doetinchem, Netherlands, 7009 BL
Novartis Investigative Site
Ede, Netherlands, 6710 HN
Novartis Investigative Site
Gouda, Netherlands, 2800 BB
Novartis Investigative Site
Groningen, Netherlands, NL-9711 SG
Novartis Investigative Site
Haarlem, Netherlands, 2035 RC
Novartis Investigative Site
Heerlen, Netherlands, 6419 PC
Novartis Investigative Site
Hoorn, Netherlands, 1625 HV
Novartis Investigative Site
Leeuwarden, Netherlands, 8934 AD
Novartis Investigative Site
Maastricht, Netherlands, 5800
Novartis Investigative Site
Meppel, Netherlands, 7943 KA
Novartis Investigative Site
Nijmegen, Netherlands
Novartis Investigative Site
Rotterdam, Netherlands, 3001 HG
Novartis Investigative Site
Rotterdam, Netherlands, 3083 AN
Novartis Investigative Site
Tiel, Netherlands, 4002 WP
Novartis Investigative Site
Utrecht, Netherlands, 3584 CX
Novartis Investigative Site
Venlo, Netherlands, 5912 BL
Norway
Novartis Investigative Site
Elverum, Norway, 2408
Novartis Investigative Site
Hamar, Norway, 2317
Novartis Investigative Site
Harstad, Norway, 9481
Novartis Investigative Site
Hønefoss, Norway, 3501
Novartis Investigative Site
Lillehammer, Norway, 2629
Novartis Investigative Site
Moss, Norway, 1530
Novartis Investigative Site
Nesttun, Norway, 5221
Novartis Investigative Site
Oslo, Norway, 0424
Novartis Investigative Site
Oslo, Norway, 0303
Novartis Investigative Site
Sandefjord, Norway, 3211
Novartis Investigative Site
Skedsmokorset, Norway, 2020
Novartis Investigative Site
Stavanger, Norway, 4068
Novartis Investigative Site
Trondheim, Norway, 7011
Novartis Investigative Site
Tynset, Norway, 2501
Novartis Investigative Site
Tønsberg, Norway, 3116
Novartis Investigative Site
Ålesund, Norway, NO-6026
Peru
Novartis Investigative Site
Bellavista, Lima, Peru, Callao 02
Novartis Investigative Site
San Isidro, Lima, Peru, 27
Novartis Investigative Site
San Martin de Porres, Lima, Peru, 31
Novartis Investigative Site
Lima, Peru, Lima 39
Poland
Novartis Investigative Site
Gdansk, Poland, 80-435
Novartis Investigative Site
Gdynia, Poland, 81-157
Novartis Investigative Site
Gdynia, Poland, 81-519
Novartis Investigative Site
Gdynia, Poland, 81-423
Novartis Investigative Site
Lublin, Poland, 20-538
Novartis Investigative Site
Olawa, Poland, 55-200
Novartis Investigative Site
Ostrow Wielkopolski, Poland, 63-400
Novartis Investigative Site
Poznan, Poland, 60-375
Novartis Investigative Site
Poznan, Poland, 61-874
Novartis Investigative Site
Pulawy, Poland, 24-100
Novartis Investigative Site
Rumia, Poland, 84-230
Novartis Investigative Site
Skierniewice, Poland, 96-100
Novartis Investigative Site
Torun, Poland, 87-100
Novartis Investigative Site
Warszawa, Poland, 04-073
Novartis Investigative Site
Wegrow, Poland, 07-100
Novartis Investigative Site
Wloclawek, Poland, 87-800
Puerto Rico
Novartis Investigative Site
Manati, Puerto Rico, 00674
Novartis Investigative Site
Mayaguez, Puerto Rico, 00680
Novartis Investigative Site
Ponce, Puerto Rico, 00716
Novartis Investigative Site
Ponce, Puerto Rico, 00717
Novartis Investigative Site
San Juan, Puerto Rico, 00909
Novartis Investigative Site
San Juan, Puerto Rico, 00926
Novartis Investigative Site
San Juan, Puerto Rico, 00936-6528
Romania
Novartis Investigative Site
Bucharest, District 1, Romania
Novartis Investigative Site
Bucuresti, District 1, Romania, 010225
Novartis Investigative Site
Bucharest, District 2, Romania
Novartis Investigative Site
Bucuresti, District 4, Romania, 4204179
Novartis Investigative Site
Cluj Napoca, Jud Cluj, Romania, 400015
Novartis Investigative Site
Targu Mures, jud Mures, Romania, 540043
Novartis Investigative Site
Oradea, Jud. Bihor, Romania, 410169
Novartis Investigative Site
Constanta, Jud. Constanta, Romania, 900591
Novartis Investigative Site
Craiova, Jud. Dolj, Romania, 200147
Novartis Investigative Site
Iasi, Jud. Iasi, Romania, 700111
Novartis Investigative Site
Iasi, Jud. Iasi, Romania, 700005
Novartis Investigative Site
Timisoara, jud. Timis, Romania, 300359
Novartis Investigative Site
Targu Mures, Mures, Romania, 540124
Novartis Investigative Site
Baia Mare, Romania, 430123
Novartis Investigative Site
Braila, Romania, 810249
Novartis Investigative Site
Brasov, Romania, 500281
Novartis Investigative Site
Bucharest, Romania, 021659
Novartis Investigative Site
Bucuresti, Romania, 011728
Novartis Investigative Site
Bucuresti, Romania, 011774
Novartis Investigative Site
Cluj Napoca, Romania, 400006
Novartis Investigative Site
Cluj-Napoca, Romania, 400347
Novartis Investigative Site
Craiova, Romania, 200642
Novartis Investigative Site
Pitesti, Romania, 110114
Novartis Investigative Site
Sibiu, Romania, 550371
Novartis Investigative Site
Targu Mures, Romania, 540096
Novartis Investigative Site
Targu-Mures, Romania, 540142
Novartis Investigative Site
Targu-Mures, Romania, 540136
Novartis Investigative Site
Tg. Mures, Romania, 540136
Novartis Investigative Site
Timisoara, Romania, 300310
Novartis Investigative Site
Timisoara, Romania, 300736
Russian Federation
Novartis Investigative Site
Chelyabinsk, Russian Federation, 454048
Novartis Investigative Site
Chelyabinsk, Russian Federation, 454091
Novartis Investigative Site
Chelyabinsk, Russian Federation, 454047
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620102
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620109
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620219
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620137
Novartis Investigative Site
Izhevsk, Russian Federation, 426063
Novartis Investigative Site
Kazan, Russian Federation, 420012
Novartis Investigative Site
Kemerovo, Russian Federation, 650029
Novartis Investigative Site
Kirov, Russian Federation, 610014
Novartis Investigative Site
Kirov, Russian Federation, 610027
Novartis Investigative Site
Krasnodar, Russian Federation, 350086
Novartis Investigative Site
Moscow, Russian Federation, 117556
Novartis Investigative Site
Moscow, Russian Federation, 117198
Novartis Investigative Site
Moscow, Russian Federation, 111539
Novartis Investigative Site
Moscow, Russian Federation, 127473
Novartis Investigative Site
Moscow, Russian Federation, 125284
Novartis Investigative Site
Moscow, Russian Federation, 127018
Novartis Investigative Site
Moscow, Russian Federation, 119881
Novartis Investigative Site
Novosibirsk, Russian Federation, 630087
Novartis Investigative Site
Penza, Russian Federation, 440067
Novartis Investigative Site
Perm, Russian Federation, 614097
Novartis Investigative Site
Perm, Russian Federation, 614107
Novartis Investigative Site
Petrozavodsk, Russian Federation, 185019
Novartis Investigative Site
Ryazan, Russian Federation, 390026
Novartis Investigative Site
Saint Petersburg, Russian Federation, 199106
Novartis Investigative Site
Saint Petersburg, Russian Federation, 195067
Novartis Investigative Site
Saint-Petersburg, Russian Federation, 195257
Novartis Investigative Site
Saint-Petersburg, Russian Federation, 197341
Novartis Investigative Site
Samara, Russian Federation, 443070
Novartis Investigative Site
Samara, Russian Federation, 443096
Novartis Investigative Site
Sankt-Peterburg, Russian Federation, 197022
Novartis Investigative Site
Saratov, Russian Federation, 410028
Novartis Investigative Site
Saratov, Russian Federation, 410012
Novartis Investigative Site
Sestroreck, Russian Federation, 197706
Novartis Investigative Site
Smolensk, Russian Federation, 214018
Novartis Investigative Site
St-Petersburg, Russian Federation, 194295
Novartis Investigative Site
St-Petersburg, Russian Federation, 196084
Novartis Investigative Site
St. Petersburg, Russian Federation, 198013
Novartis Investigative Site
St.- Petersburg, Russian Federation, 197110
Novartis Investigative Site
St.-Petersburg, Russian Federation, 194044
Novartis Investigative Site
St.Petersburg, Russian Federation, 193163
Novartis Investigative Site
Syktyvkar, Russian Federation, 167981
Novartis Investigative Site
Tomsk, Russian Federation, 634012
Novartis Investigative Site
Tyumen, Russian Federation, 625026
Novartis Investigative Site
Vladimir, Russian Federation, 600020
Novartis Investigative Site
Yaroslavl, Russian Federation, 150047
Serbia
Novartis Investigative Site
Beograd, Serbia, 11040
Novartis Investigative Site
Nis, Serbia, 18000
Novartis Investigative Site
Niska Banja, Serbia, 18205
Novartis Investigative Site
Sremska Kamenica, Serbia, 21204
Slovakia
Novartis Investigative Site
Bratislava, Slovak Republic, Slovakia, 826 06
Novartis Investigative Site
Brezno, Slovak Republic, Slovakia, 977 42
Novartis Investigative Site
Komarno, Slovak Republic, Slovakia, 94575
Novartis Investigative Site
Kosice, Slovak Republic, Slovakia, 040 22
Novartis Investigative Site
Povazska Bystrica, Slovak Republic, Slovakia, 017 01
Novartis Investigative Site
Presov, Slovak Republic, Slovakia, 080 01
Novartis Investigative Site
Presov, Slovak Republic, Slovakia, 08001
Novartis Investigative Site
Rimavska Sobota, Slovak republic, Slovakia, 97901
Novartis Investigative Site
Svidnik, Slovak Republic, Slovakia, 08901
Novartis Investigative Site
Velky Krtis, Slovak Republic, Slovakia, 990 01
Novartis Investigative Site
Banska Bystrica, Slovakia, 97401
Novartis Investigative Site
Bardejov, Slovakia, 085 01
Novartis Investigative Site
Bratislava, Slovakia, 81369
Novartis Investigative Site
Bratislava, Slovakia, 831 06
Novartis Investigative Site
Bratislava, Slovakia, 841 08
Novartis Investigative Site
Dubnica nad Vahom, Slovakia, 01841
Novartis Investigative Site
Dunajska Streda, Slovakia, 929 01
Novartis Investigative Site
Galanta, Slovakia, 92701
Novartis Investigative Site
Kosice, Slovakia, 040 01
Novartis Investigative Site
Kosice, Slovakia, 04001
Novartis Investigative Site
Levice, Slovakia, 934 01
Novartis Investigative Site
Lucenec, Slovakia, 984 01
Novartis Investigative Site
Lucenec, Slovakia, 98403
Novartis Investigative Site
Martin, Slovakia, 036 01
Novartis Investigative Site
Nitra, Slovakia, 94901
Novartis Investigative Site
Nitra, Slovakia, 949 01
Novartis Investigative Site
Nove Zamky, Slovakia, 940 01
Novartis Investigative Site
Presov, Slovakia, 081 01
Novartis Investigative Site
Trnava, Slovakia, 91702
Novartis Investigative Site
Zilina, Slovakia, 012 07
Slovenia
Novartis Investigative Site
Celje, Slovenia, 3000
Novartis Investigative Site
Golnik, Slovenia, 4204
Novartis Investigative Site
Ljubljana, Slovenia, 1000
South Africa
Novartis Investigative Site
Alberton, South Africa, 1449
Novartis Investigative Site
Bloemfontein, South Africa, 9301
Novartis Investigative Site
Cape Town, South Africa
Novartis Investigative Site
Cape Town, South Africa, 7925
Novartis Investigative Site
Cape Town, South Africa, 7405
Novartis Investigative Site
Centurion, South Africa, 4001
Novartis Investigative Site
Durban, South Africa, 4052
Novartis Investigative Site
Johannesburg, South Africa, 2193
Novartis Investigative Site
Kempton Park, South Africa, 1620
Novartis Investigative Site
Pretoria, South Africa, 0002
Sweden
Novartis Investigative Site
Boras, Sweden, 506 30
Novartis Investigative Site
Göteborg, Sweden, 413 45
Novartis Investigative Site
Göteborg, Sweden, 416 85
Novartis Investigative Site
Kristianstad, Sweden, 291 85
Novartis Investigative Site
Luleå, Sweden, 972 33
Novartis Investigative Site
Lund, Sweden, 221 85
Novartis Investigative Site
Lund, Sweden, SE-222 21
Novartis Investigative Site
Malmö, Sweden, 214 22
Novartis Investigative Site
Mölndal, Sweden, 431 80
Novartis Investigative Site
Skanör, Sweden, 239 33
Novartis Investigative Site
Skelleftea, Sweden, 931 86
Novartis Investigative Site
Stockholm, Sweden, 118 83
Novartis Investigative Site
Stockholm, Sweden, SE-111 35
Novartis Investigative Site
Uddevalla, Sweden, 451 50
Novartis Investigative Site
Vällingby, Sweden, 162 68
Novartis Investigative Site
Västerås, Sweden, s-721 89
Novartis Investigative Site
Östersund, Sweden, 831 83
Taiwan
Novartis Investigative Site
Yungkang, Tainan, Taiwan, 710
Novartis Investigative Site
Taichung, Taiwan ROC, Taiwan, 40201
Novartis Investigative Site
Taipei, Taiwan, ROC, Taiwan, 112
Novartis Investigative Site
Changhua, Taiwan, 500
Novartis Investigative Site
Ilan, Taiwan
Novartis Investigative Site
Kaohsiung, Taiwan, 807
Novartis Investigative Site
Lin-Kou, Taiwan, 33305
Novartis Investigative Site
Niaosong Township, Taiwan, 83301
Novartis Investigative Site
Taichung, Taiwan, 40447
Novartis Investigative Site
Taipei, Taiwan, 10002
Novartis Investigative Site
Taipei, Taiwan, 114
Novartis Investigative Site
Taipei, Taiwan
Turkey
Novartis Investigative Site
Aydin, Turkey, 09100
Novartis Investigative Site
Balcova / Izmir, Turkey, 35340
Novartis Investigative Site
Istanbul, Turkey, 34304
Novartis Investigative Site
Izmir, Turkey, 35040
Novartis Investigative Site
Kocaeli, Turkey, 41380
Novartis Investigative Site
Mersin, Turkey, 33079
Novartis Investigative Site
Meselik / Eskisehir, Turkey, 26480
Novartis Investigative Site
Sivas, Turkey, 58140
United Kingdom
Novartis Investigative Site
Basingstoke, Hampshire, United Kingdom, RG24 9NA
Novartis Investigative Site
Newport, Isle of Wight, United Kingdom, PO30 5TG
Novartis Investigative Site
Salford, Manchester, United Kingdom, M6 8HD
Novartis Investigative Site
Whitby, North Yorkshire, United Kingdom, Y021 1SD
Novartis Investigative Site
Nottingham, Nottinghamshire, United Kingdom, NG17 4JL
Novartis Investigative Site
Dundee, Perthshire, United Kingdom, DD1 2BU
Novartis Investigative Site
Axbridge, Somerset, United Kingdom, BS26 2BJ
Novartis Investigative Site
Taunton, Somerset, United Kingdom, TA1 5DA
Novartis Investigative Site
Barnet, United Kingdom, EN5 3DJ
Novartis Investigative Site
Berkshire, United Kingdom, RG2 0TG
Novartis Investigative Site
Birmingham, United Kingdom, B15 2SQ
Novartis Investigative Site
Birmingham, United Kingdom, B15 2TH
Novartis Investigative Site
Birmingham, United Kingdom, B9 5SS
Novartis Investigative Site
Cardiff, United Kingdom, CF14 5GJ
Novartis Investigative Site
Cardiff, United Kingdom, CF5 4AD
Novartis Investigative Site
Cheshire, United Kingdom, CW11 1EQ
Novartis Investigative Site
Chesterfield, United Kingdom, S40 4AA
Novartis Investigative Site
Chorley, United Kingdom, PR7 7NA
Novartis Investigative Site
Exeter, United Kingdom, EX2 5DW
Novartis Investigative Site
Glasgow, United Kingdom, G11 6NT
Novartis Investigative Site
Glasgow, United Kingdom, G20 0SP
Novartis Investigative Site
Glasgow, United Kingdom, G20 0XA
Novartis Investigative Site
Irvine, United Kingdom, KA12 0AY
Novartis Investigative Site
Leicester, United Kingdom, LE3 9QP
Novartis Investigative Site
Liverpool, United Kingdom, L22 0LG
Novartis Investigative Site
London, United Kingdom, EC14 7BE
Novartis Investigative Site
Manchester, United Kingdom, M15 6SX
Novartis Investigative Site
Newcastle Upon Tyne, United Kingdom, NE7 7DN
Novartis Investigative Site
Newport, United Kingdom, NP20 2UB
Novartis Investigative Site
Norwich, United Kingdom, NR4 7UY
Novartis Investigative Site
Nottingham, United Kingdom, NG5 1PB
Novartis Investigative Site
Sheffield, United Kingdom, S5 7AU
Novartis Investigative Site
Wiltshire, United Kingdom, SN15 2SB
Novartis Investigative Site
Worcester, United Kingdom, WR5 1DD
Novartis Investigative Site
York, United Kingdom, YO31 8HE
Sponsors and Collaborators
Novartis Pharmaceuticals
Investigators
Study Director: Novartis Pharmaceuticals Novartis Pharmaceuticals
  More Information

No publications provided by Novartis

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier: NCT01327846     History of Changes
Other Study ID Numbers: CACZ885M2301, 2010-022970-14
Study First Received: March 29, 2011
Last Updated: May 19, 2015
Health Authority: United States: Food and Drug Administration

Keywords provided by Novartis:
Cardiovascular Death
Myocardial Infarction
Stroke
Canakinumab
IL-1B
hsCRP

Additional relevant MeSH terms:
Arteriosclerosis
Atherosclerosis
Myocardial Infarction
Arterial Occlusive Diseases
Cardiovascular Diseases
Heart Diseases
Myocardial Ischemia
Vascular Diseases
Antibodies, Monoclonal
Immunologic Factors
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on August 27, 2015