Akt Inhibitor MK2206 in Treating Patients With Advanced Gastric or Gastroesophageal Junction Cancer
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01260701 |
Recruitment Status
:
Completed
First Posted
: December 15, 2010
Results First Posted
: August 4, 2014
Last Update Posted
: January 18, 2016
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Adenocarcinoma of the Gastroesophageal Junction Diffuse Gastric Adenocarcinoma Gastric Intestinal Type Adenocarcinoma Gastric Mixed Adenocarcinoma Recurrent Gastric Carcinoma | Drug: Akt Inhibitor MK2206 | Phase 2 |
PRIMARY OBJECTIVES:
I. To estimate the overall survival (OS) for patients with advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma treated with MK-2206 (Akt inhibitor MK2206).
SECONDARY OBJECTIVES:
I. To estimate the progression free survival (PFS) in this patient population. II. To estimate the response rate (confirmed and unconfirmed complete response [CR] and partial response [PR] by Response Evaluation Criteria In Solid Tumors [RECIST] 1.1) in this patient population.
III. To assess the frequency and severity of toxicity associated with this regimen.
OUTLINE (CLOSED TO ACCRUAL 05/01/13):
Patients receive Akt inhibitor MK2206 orally (PO) every other day on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study therapy, patients are followed up every 3 months for 2 years.
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 75 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | A Phase II Study of MK-2206 (NSC-749607) as Second Line Therapy for Advanced Gastric and Gastroesophageal Junction Cancer |
Study Start Date : | January 2011 |
Actual Primary Completion Date : | May 2014 |
Actual Study Completion Date : | July 2015 |
Arm | Intervention/treatment |
---|---|
Experimental: Treatment (CLOSED TO ACCRUAL 05/01/13)
Patients receive Akt inhibitor MK2206 PO every other day on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
|
Drug: Akt Inhibitor MK2206
Given PO
Other Name: MK2206
|
- Overall Survival (OS) [ Time Frame: Up to 2 years ]Overall survival is calculated from date of registration to date of death due to any cause. Patients last known to be alive are censored at date of last contact.
- Progression Free Survival (PFS) [ Time Frame: Up to 2 years ]PFS is measured from date of registration to date of first documentation of progression or symptomatic deterioration, or death due to any cause. Patients last known to be alive and without report of progression are censored at date of last contact. Progression is one or more of the following: 20% increase in the sum of appropriate diameters of target measurable lesions over smallest sum observed (over baseline if no decrease during therapy), as well as an absolute increase of at least 0.5 cm; unequivocal progression of non-measurable disease in the opinion of the treating physician; appearance of any new lesion/site; death due to disease without prior documentation of progression and without symptomatic deterioration. Symptomatic deterioration is global deterioration of health status requiring discontinuation of treatment without objective evidence of progression.
- Response Rate (Complete and Partial, Confirmed and Unconfirmed) [ Time Frame: Up to 2 years ]Complete response (CR) is complete disappearance of all target and non-target lesions, no new lesions, and no disease related symptoms. Any lymph nodes must have reduction in short axis to < 1.0 cm. Partial response (PR) is >= 30% decrease under baseline of the sum of appropriate diameters of all target measurable lesions, no unequivocal progression of non-measurable disease, and no new lesions. Confirmed CR is two or more statuses of CR a minimum of four weeks apart documented before progression or symptomatic deterioration. Confirmed PR is two or more statuses of PR or better a minimum of four weeks apart documented before progression or symptomatic deterioration, but not qualifying as CR. Unconfirmed CR is one status of CR documented before progression or symptomatic deterioration but not qualifying as CR or PR. Unconfirmed PR is one status of PR documented before progression or symptomatic deterioration but not qualifying as CR, PR or unconfirmed CR.
- Number of Patients With Grade 3 Through 5 Adverse Events That Are Related to Study Drug [ Time Frame: Up to 2 years ]Any CTCAE 4.0 event of Grade 3 (severe), Grade 4 (life threatening), or Grade 5 (fatal) which were possibly, probably or definitely related to protocol treatment are included.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients must have histologically or cytologically confirmed adenocarcinoma of the stomach or gastroesophageal (GE) junction that has progressed after first-line treatment, or is recurrent within 6 months after receiving adjuvant therapy; patients must have had exactly one prior systemic treatment regimen; previous adjuvant (chemotherapy [chemo]) radiotherapy is permitted; prior chemotherapy given concurrently with radiation for radiosensitization is not considered one prior systemic regimen
- Patients must have measurable disease; computed tomography (CT) scans or magnetic resonance imaging (MRIs) used to assess measurable disease must have been completed within 28 days prior to registration; CT scans or MRIs used to assess non-measurable disease must have been completed within 42 days prior to registration; all disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1)
- Patients must not have known brain metastases
- Patients must not have received chemotherapy or radiotherapy within 3 weeks (6 weeks for nitrosoureas or mitomycin C) prior to registration
- Patient must not have received prior treatment with a phosphatidylinositol 3 (PI3), v-akt murine thymoma viral oncogene homolog 1 (AKT) or mechanistic target of rapamycin (Mtor) inhibitor for any reason
- All toxicities from prior therapy must have resolved to =< grade 1 (Common Terminology Criteria for Adverse Events [CTCAE] version 4.0) prior to registration
- Patients must not be receiving or planning to receive any other investigational agents
- Patients must be able to tolerate oral medications and must not have malabsorption or chronic diarrhea (CTCAE version 4.0 grade 2 or higher); administration through a feeding tube is not permitted
- Hemoglobin >= 9 g/dL
- Absolute neutrophil count (ANC) >= 1,500/mcL
- Platelets >= 100,000/mcL
- Total bilirubin =< institutional upper limit of normal (IULN)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 2.5 x IULN; patients with liver metastases must have AST and ALT =< 5 x IULN
-
Patients must have adequate kidney function as evidenced by at least ONE of the following:
- Serum creatinine (mg/dL) =< IULN obtained within 14 days prior to registration
- Calculated creatinine clearance > 50 ml/min; the serum creatinine value used in the calculation must have been obtained within 14 days prior to registration
- Patients must have international normalized ratio (INR) =< 1.2 unless taking therapeutic doses of warfarin; this result must be obtained within 14 days prior to registration
- Patients must have fasting blood sugar =< 150 mg/dL within 28 days prior to registration
- Patients must have hemoglobin A1C < 7% within 28 days prior to registration
- Patients must have an electrocardiogram (ECG) within 28 days prior to registration; patients must have corrected QT interval (QTcF) (by Fridericia's calculation) < 450 msec (male) or < 470 msec (female)
- Patients must have a Zubrod performance status of 0-1
- Patient must not have any of the following: a history of congenital long QT syndrome; use of concomitant medications that could prolong the QTc interval; New York Heart Association class III or IV heart failure; history of myocardial infarction within 6 months prior to registration; uncontrolled dysrhythmias; poorly controlled angina; resting heart rate =< 50 bpm (bradycardia)
- Patients must not be receiving concurrent treatment with drugs that are strong inducers or inhibitors of cytochrome P450 family 3, subfamily A, polypeptide 4 (CYP3A4); patients must be able to safely discontinue treatment with these agents for >= 2 weeks prior to beginning protocol therapy
- Patient must not have uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
- Patient must not be pregnant or nursing; women/men of reproductive potential must have agreed to use two forms of contraception for the duration of protocol treatment and for one month after discontinuation of MK-2206; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any time a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
- No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years
- All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01260701

United States, Alabama | |
Providence Hospital | |
Mobile, Alabama, United States, 36608 | |
United States, Alaska | |
Fairbanks Memorial Hospital | |
Fairbanks, Alaska, United States, 99701 | |
United States, Arizona | |
The University of Arizona Cancer Center-Orange Grove Campus | |
Tucson, Arizona, United States, 85704 | |
The University of Arizona Cancer Center-North Campus | |
Tucson, Arizona, United States, 85719 | |
The University of Arizona Medical Center-University Campus | |
Tucson, Arizona, United States, 85724 | |
United States, Arkansas | |
Fowler Family Center for Cancer Care | |
Jonesboro, Arkansas, United States, 72401 | |
NEA Baptist Memorial Hospital | |
Jonesboro, Arkansas, United States, 72401 | |
University of Arkansas for Medical Sciences | |
Little Rock, Arkansas, United States, 72205 | |
United States, California | |
USC / Norris Comprehensive Cancer Center | |
Los Angeles, California, United States, 90033 | |
UC Irvine Health/Chao Family Comprehensive Cancer Center | |
Orange, California, United States, 92868 | |
United States, Colorado | |
Poudre Valley Hospital | |
Fort Collins, Colorado, United States, 80524 | |
Front Range Cancer Specialists | |
Fort Collins, Colorado, United States, 80528 | |
United States, Connecticut | |
Saint Francis Hospital and Medical Center | |
Hartford, Connecticut, United States, 06105 | |
United States, Florida | |
UF Cancer Center at Orlando Health | |
Orlando, Florida, United States, 32806 | |
United States, Georgia | |
Memorial University Medical Center | |
Savannah, Georgia, United States, 31404 | |
United States, Hawaii | |
Oncare Hawaii Inc-Pali Momi | |
Aiea, Hawaii, United States, 96701 | |
Pali Momi Medical Center | |
Aiea, Hawaii, United States, 96701 | |
Oncare Hawaii Inc-POB II | |
Honolulu, Hawaii, United States, 96813 | |
Queen's Medical Center | |
Honolulu, Hawaii, United States, 96813 | |
Straub Clinic and Hospital | |
Honolulu, Hawaii, United States, 96813 | |
University of Hawaii Cancer Center | |
Honolulu, Hawaii, United States, 96813 | |
OnCare Hawaii-Liliha | |
Honolulu, Hawaii, United States, 96817-3169 | |
Kuakini Medical Center | |
Honolulu, Hawaii, United States, 96817 | |
Oncare Hawaii Inc-Kuakini | |
Honolulu, Hawaii, United States, 96817 | |
Kapiolani Medical Center for Women and Children | |
Honolulu, Hawaii, United States, 96826 | |
Castle Medical Center | |
Kailua, Hawaii, United States, 96734 | |
Wilcox Memorial Hospital and Kauai Medical Clinic | |
Lihue, Hawaii, United States, 96766 | |
United States, Idaho | |
Saint Alphonsus Cancer Care Center-Boise | |
Boise, Idaho, United States, 83706 | |
United States, Illinois | |
Cadence Cancer Center at Delnor | |
Geneva, Illinois, United States, 60134 | |
Loyola University Medical Center | |
Maywood, Illinois, United States, 60153 | |
Cadence Cancer Center in Warrenville | |
Warrenville, Illinois, United States, 60555 | |
United States, Indiana | |
Franciscan St. Francis Health-Beech Grove | |
Beech Grove, Indiana, United States, 46107 | |
Franciscan Saint Francis Health-Indianapolis | |
Indianapolis, Indiana, United States, 46237 | |
Reid Hospital and Health Care Services | |
Richmond, Indiana, United States, 47374 | |
United States, Kansas | |
Cancer Center of Kansas - Chanute | |
Chanute, Kansas, United States, 66720 | |
Cancer Center of Kansas - Dodge City | |
Dodge City, Kansas, United States, 67801 | |
Cancer Center of Kansas - Fort Scott | |
Fort Scott, Kansas, United States, 66701 | |
Saint Rose Ambulatory and Surgery Center | |
Great Bend, Kansas, United States, 67530 | |
Hays Medical Center | |
Hays, Kansas, United States, 67601 | |
Hutchinson Regional Medical Center | |
Hutchinson, Kansas, United States, 67502 | |
Cancer Center of Kansas-Independence | |
Independence, Kansas, United States, 67301 | |
The University of Kansas Cancer Center-West | |
Kansas City, Kansas, United States, 66112 | |
University of Kansas Cancer Center | |
Kansas City, Kansas, United States, 66160 | |
Cancer Center of Kansas-Kingman | |
Kingman, Kansas, United States, 67068 | |
Lawrence Memorial Hospital | |
Lawrence, Kansas, United States, 66044 | |
Cancer Center of Kansas-Liberal | |
Liberal, Kansas, United States, 67901 | |
Cancer Center of Kansas - Newton | |
Newton, Kansas, United States, 67114 | |
Kansas City Cancer Centers-Southwest | |
Overland Park, Kansas, United States, 66210 | |
Cancer Center of Kansas - Parsons | |
Parsons, Kansas, United States, 67357 | |
Via Christi Hospital-Pittsburg | |
Pittsburg, Kansas, United States, 66762 | |
Cancer Center of Kansas - Pratt | |
Pratt, Kansas, United States, 67124 | |
Cancer Center of Kansas - Salina | |
Salina, Kansas, United States, 67401 | |
Salina Regional Health Center | |
Salina, Kansas, United States, 67401 | |
Kansas City Cancer Center-Shawnee Mission | |
Shawnee Mission, Kansas, United States, 66204 | |
Saint Francis Hospital and Medical Center - Topeka | |
Topeka, Kansas, United States, 66606 | |
Cancer Center of Kansas - Wellington | |
Wellington, Kansas, United States, 67152 | |
Associates In Womens Health | |
Wichita, Kansas, United States, 67208 | |
Cancer Center of Kansas-Wichita Medical Arts Tower | |
Wichita, Kansas, United States, 67208 | |
Cancer Center of Kansas - Main Office | |
Wichita, Kansas, United States, 67214 | |
Via Christi Regional Medical Center | |
Wichita, Kansas, United States, 67214 | |
Wichita CCOP | |
Wichita, Kansas, United States, 67214 | |
Cancer Center of Kansas - Winfield | |
Winfield, Kansas, United States, 67156 | |
United States, Maryland | |
Sinai Hospital of Baltimore | |
Baltimore, Maryland, United States, 21215 | |
United States, Michigan | |
Saint Joseph Mercy Hospital | |
Ann Arbor, Michigan, United States, 48106-0995 | |
Michigan Cancer Research Consortium CCOP | |
Ann Arbor, Michigan, United States, 48106 | |
Bronson Battle Creek | |
Battle Creek, Michigan, United States, 49017 | |
Spectrum Health Big Rapids Hospital | |
Big Rapids, Michigan, United States, 49307 | |
Oakwood Hospital and Medical Center | |
Dearborn, Michigan, United States, 48124 | |
Saint John Hospital and Medical Center | |
Detroit, Michigan, United States, 48236 | |
Hurley Medical Center | |
Flint, Michigan, United States, 48502 | |
Genesys Hurley Cancer Institute | |
Flint, Michigan, United States, 48503 | |
Genesys Regional Medical Center-West Flint Campus | |
Flint, Michigan, United States, 48532 | |
Grand Rapids Clinical Oncology Program | |
Grand Rapids, Michigan, United States, 49503 | |
Mercy Health Saint Mary's | |
Grand Rapids, Michigan, United States, 49503 | |
Spectrum Health at Butterworth Campus | |
Grand Rapids, Michigan, United States, 49503 | |
Allegiance Health | |
Jackson, Michigan, United States, 49201 | |
Sparrow Hospital | |
Lansing, Michigan, United States, 48912 | |
Saint Mary Mercy Hospital | |
Livonia, Michigan, United States, 48154 | |
Mercy Health Mercy Campus | |
Muskegon, Michigan, United States, 49444 | |
Saint Joseph Mercy Oakland | |
Pontiac, Michigan, United States, 48341 | |
Saint Joseph Mercy Port Huron | |
Port Huron, Michigan, United States, 48060 | |
Spectrum Health Reed City Hospital | |
Reed City, Michigan, United States, 49677 | |
Saint Mary's of Michigan | |
Saginaw, Michigan, United States, 48601 | |
Munson Medical Center | |
Traverse City, Michigan, United States, 49684 | |
Saint John Macomb-Oakland Hospital | |
Warren, Michigan, United States, 48093 | |
Metro Health Hospital | |
Wyoming, Michigan, United States, 49519 | |
United States, Missouri | |
Truman Medical Center | |
Kansas City, Missouri, United States, 64108 | |
Kansas City Cancer Center - South | |
Kansas City, Missouri, United States, 64131 | |
Kansas City Cancer Centers - North | |
Kansas City, Missouri, United States, 64154 | |
Kansas City Cancer Center-Lee's Summit | |
Lee's Summit, Missouri, United States, 64064 | |
Saint John's Clinic-Rolla-Cancer and Hematology | |
Rolla, Missouri, United States, 65401 | |
Saint Louis University Hospital | |
Saint Louis, Missouri, United States, 63110 | |
Cancer Research for the Ozarks NCORP | |
Springfield, Missouri, United States, 65804 | |
Mercy Hospital Springfield | |
Springfield, Missouri, United States, 65804 | |
CoxHealth South Hospital | |
Springfield, Missouri, United States, 65807 | |
United States, Montana | |
Montana Cancer Consortium NCORP | |
Billings, Montana, United States, 59101 | |
Saint Vincent Healthcare | |
Billings, Montana, United States, 59101 | |
Frontier Cancer Center and Blood Institute-Billings | |
Billings, Montana, United States, 59102 | |
Billings Clinic Cancer Center | |
Billings, Montana, United States, 59107 | |
Bozeman Deaconess Cancer Center | |
Bozeman, Montana, United States, 59715 | |
Bozeman Deaconess Hospital | |
Bozeman, Montana, United States, 59715 | |
Saint James Community Hospital and Cancer Treatment Center | |
Butte, Montana, United States, 59701 | |
Benefis Healthcare- Sletten Cancer Institute | |
Great Falls, Montana, United States, 59405 | |
Great Falls Clinic | |
Great Falls, Montana, United States, 59405 | |
Saint Peter's Community Hospital | |
Helena, Montana, United States, 59601 | |
Glacier Oncology PLLC | |
Kalispell, Montana, United States, 59901 | |
Kalispell Regional Medical Center | |
Kalispell, Montana, United States, 59901 | |
Montana Cancer Specialists | |
Missoula, Montana, United States, 59802 | |
Saint Patrick Hospital - Community Hospital | |
Missoula, Montana, United States, 59802 | |
United States, New York | |
Winthrop University Hospital | |
Mineola, New York, United States, 11501 | |
Interlakes Foundation Inc-Rochester | |
Rochester, New York, United States, 14623 | |
University of Rochester | |
Rochester, New York, United States, 14642 | |
United States, North Carolina | |
Randolph Hospital | |
Asheboro, North Carolina, United States, 27203 | |
Novant Health Presbyterian Medical Center | |
Charlotte, North Carolina, United States, 28204 | |
Wayne Memorial Hospital | |
Goldsboro, North Carolina, United States, 27534 | |
Cone Health Cancer Center | |
Greensboro, North Carolina, United States, 27403 | |
Iredell Memorial Hospital | |
Statesville, North Carolina, United States, 28677 | |
Southeast Cancer Control Consortium CCOP | |
Winston-Salem, North Carolina, United States, 27104 | |
United States, Ohio | |
Akron General Medical Center | |
Akron, Ohio, United States, 44307 | |
Mary Rutan Hospital | |
Bellefontaine, Ohio, United States, 43311 | |
Adena Regional Medical Center | |
Chillicothe, Ohio, United States, 45601 | |
Good Samaritan Hospital - Cincinnati | |
Cincinnati, Ohio, United States, 45220 | |
University of Cincinnati | |
Cincinnati, Ohio, United States, 45267 | |
Riverside Methodist Hospital | |
Columbus, Ohio, United States, 43214 | |
Columbus CCOP | |
Columbus, Ohio, United States, 43215 | |
Grant Medical Center | |
Columbus, Ohio, United States, 43215 | |
Mount Carmel Health Center West | |
Columbus, Ohio, United States, 43222 | |
Doctors Hospital | |
Columbus, Ohio, United States, 43228 | |
Grandview Hospital | |
Dayton, Ohio, United States, 45405 | |
Good Samaritan Hospital - Dayton | |
Dayton, Ohio, United States, 45406 | |
Miami Valley Hospital | |
Dayton, Ohio, United States, 45409 | |
Samaritan North Health Center | |
Dayton, Ohio, United States, 45415 | |
Dayton CCOP | |
Dayton, Ohio, United States, 45420 | |
Grady Memorial Hospital | |
Delaware, Ohio, United States, 43015 | |
Blanchard Valley Hospital | |
Findlay, Ohio, United States, 45840 | |
Atrium Medical Center-Middletown Regional Hospital | |
Franklin, Ohio, United States, 45005-1066 | |
Wayne Hospital | |
Greenville, Ohio, United States, 45331 | |
Kettering Medical Center | |
Kettering, Ohio, United States, 45429 | |
Fairfield Medical Center | |
Lancaster, Ohio, United States, 43130 | |
Marietta Memorial Hospital | |
Marietta, Ohio, United States, 45750 | |
Knox Community Hospital | |
Mount Vernon, Ohio, United States, 43050 | |
Licking Memorial Hospital | |
Newark, Ohio, United States, 43055 | |
Southern Ohio Medical Center | |
Portsmouth, Ohio, United States, 45662 | |
Springfield Regional Medical Center | |
Springfield, Ohio, United States, 45505 | |
Upper Valley Medical Center | |
Troy, Ohio, United States, 45373 | |
Saint Ann's Hospital | |
Westerville, Ohio, United States, 43081 | |
Clinton Memorial Hospital | |
Wilmington, Ohio, United States, 45177 | |
Greene Memorial Hospital | |
Xenia, Ohio, United States, 45385 | |
Genesis HealthCare System | |
Zanesville, Ohio, United States, 43701 | |
United States, Oklahoma | |
University of Oklahoma Health Sciences Center | |
Oklahoma City, Oklahoma, United States, 73104 | |
United States, Oregon | |
Oregon Health and Science University | |
Portland, Oregon, United States, 97239 | |
United States, South Carolina | |
McLeod Regional Medical Center | |
Florence, South Carolina, United States, 29506 | |
United States, Tennessee | |
University of Tennessee - Knoxville | |
Knoxville, Tennessee, United States, 37920 | |
United States, Texas | |
Baylor College of Medicine | |
Houston, Texas, United States, 77030 | |
Baylor Saint Luke's Medical Center | |
Houston, Texas, United States, 77030 | |
Ben Taub General Hospital | |
Houston, Texas, United States, 77030 | |
Michael E DeBakey VA Medical Center | |
Houston, Texas, United States, 77030 | |
United States, Virginia | |
Danville Regional Medical Center | |
Danville, Virginia, United States, 24541 | |
Memorial Hospital Of Martinsville | |
Martinsville, Virginia, United States, 24115 | |
United States, Washington | |
Cancer Care Center at Island Hospital | |
Anacortes, Washington, United States, 98221 | |
PeaceHealth Saint Joseph Medical Center | |
Bellingham, Washington, United States, 98225 | |
Harrison HealthPartners Hematology and Oncology-Bremerton | |
Bremerton, Washington, United States, 98310 | |
Highline Medical Center-Main Campus | |
Burien, Washington, United States, 98166 | |
Swedish Cancer Institute-Issaquah | |
Issaquah, Washington, United States, 98029 | |
Kadlec Clinic Hematology and Oncology | |
Kennewick, Washington, United States, 99336 | |
EvergreenHealth Medical Center | |
Kirkland, Washington, United States, 98033 | |
Seattle Cancer Care Alliance at EvergreenHealth | |
Kirkland, Washington, United States, 98034 | |
Skagit Valley Hospital | |
Mount Vernon, Washington, United States, 98274 | |
Harrison HealthPartners Hematology and Oncology-Poulsbo | |
Poulsbo, Washington, United States, 98370 | |
Virginia Mason CCOP | |
Seattle, Washington, United States, 98101 | |
Harborview Medical Center | |
Seattle, Washington, United States, 98104 | |
Minor and James Medical PLLC | |
Seattle, Washington, United States, 98104 | |
Pacific Medical Center-First Hill | |
Seattle, Washington, United States, 98104 | |
Fred Hutchinson Cancer Research Center | |
Seattle, Washington, United States, 98109 | |
Group Health Cooperative of Puget Sound Oncology Consortium | |
Seattle, Washington, United States, 98112 | |
Group Health Cooperative-Seattle | |
Seattle, Washington, United States, 98112 | |
Swedish Medical Center-First Hill | |
Seattle, Washington, United States, 98122-4307 | |
The Polyclinic | |
Seattle, Washington, United States, 98122 | |
University of Washington Medical Center | |
Seattle, Washington, United States, 98195 | |
United General Hospital | |
Sedro-Woolley, Washington, United States, 98284 | |
Cancer Care Northwest - Spokane South | |
Spokane, Washington, United States, 99202 | |
Evergreen Hematology and Oncology PS | |
Spokane, Washington, United States, 99218 | |
Rockwood Clinic | |
Spokane, Washington, United States, 99220 | |
Wenatchee Valley Hospital and Clinics | |
Wenatchee, Washington, United States, 98801 | |
United States, Wyoming | |
Rocky Mountain Oncology | |
Casper, Wyoming, United States, 82609 | |
Welch Cancer Center | |
Sheridan, Wyoming, United States, 82801 | |
Canada, British Columbia | |
BCCA-Vancouver Cancer Centre | |
Vancouver, British Columbia, Canada, V5Z 4E6 |
Principal Investigator: | Ramesh Ramanathan | Southwest Oncology Group |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT01260701 History of Changes |
Other Study ID Numbers: |
NCI-2011-02619 NCI-2011-02619 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) ) SWOG-S1005 S1005 CDR0000689602 S1005 ( Other Identifier: SWOG ) S1005 ( Other Identifier: CTEP ) U10CA180888 ( U.S. NIH Grant/Contract ) U10CA032102 ( U.S. NIH Grant/Contract ) |
First Posted: | December 15, 2010 Key Record Dates |
Results First Posted: | August 4, 2014 |
Last Update Posted: | January 18, 2016 |
Last Verified: | November 2015 |
Additional relevant MeSH terms:
Adenocarcinoma Stomach Neoplasms Esophageal Neoplasms Carcinoma Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Gastrointestinal Neoplasms |
Digestive System Neoplasms Neoplasms by Site Digestive System Diseases Gastrointestinal Diseases Stomach Diseases Head and Neck Neoplasms Esophageal Diseases |