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Exploratory Study Using Nanotechnology to Detect Biomarkers of Parkinson's Disease From Exhaled Breath

This study has been completed.
Technion, Israel Institute of Technology
Information provided by (Responsible Party):
Ilana Schlesinger, Rambam Health Care Campus Identifier:
First received: November 21, 2010
Last updated: November 4, 2015
Last verified: November 2015
Parkinson's disease is diagnosed clinically, because biomarkers that may help in diagnosis and differential diagnosis are not yet available. Exhaled breath testing may yield a "breath-print" that can be used to distinguish healthy and diseased states.

Condition Intervention
Parkinson's Disease
Other: no intervention

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Exploratory Study to Detect Volatile Biomarkers of Idiopathic Parkinson's Disease and Parkinsonism From Exhaled Breath Using a Nanomedical Artificial Olfactory System.

Resource links provided by NLM:

Further study details as provided by Rambam Health Care Campus:

Primary Outcome Measures:
  • Nanosensory detection [ Time Frame: immediate ]
    analyze combinations of nanomaterial-based sensors (organically functionalized carbon nanotubes and gold nanoparticles)

Biospecimen Retention:   Samples Without DNA
Exhaled breath

Enrollment: 41
Study Start Date: August 2009
Study Completion Date: January 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Patients with parkinsonism
Patients suffering from Parkinson's disease or parkinsonism
Healthy controls
Patients not suffering from Parkinson's disease or any other neurological disorder
Other: no intervention
no intervention


Ages Eligible for Study:   30 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients diagnosed with Idiopathic Parkinson's disease and Parkinsonism will be included.

Inclusion Criteria:

  • Patients with Parkinsonism

Exclusion Criteria:

  • Severe dementia
  Contacts and Locations
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Please refer to this study by its identifier: NCT01246336

Sponsors and Collaborators
Rambam Health Care Campus
Technion, Israel Institute of Technology
Principal Investigator: Ilana Schlesinger, MD Rambam Health Care Campus
  More Information

Responsible Party: Ilana Schlesinger, Ilana Schleainger, Rambam Health Care Campus, Rambam Health Care Campus Identifier: NCT01246336     History of Changes
Other Study ID Numbers: RMB09-0196
Study First Received: November 21, 2010
Last Updated: November 4, 2015

Keywords provided by Rambam Health Care Campus:
Parkinson's disease, Parkinsonism
Exhaled breath

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases processed this record on May 25, 2017