Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting (SIMPLICITY)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01244750 |
Recruitment Status : Unknown
Verified January 2018 by Bristol-Myers Squibb.
Recruitment status was: Active, not recruiting
First Posted : November 19, 2010
Last Update Posted : January 23, 2018
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Condition or disease | Intervention/treatment |
---|---|
Chronic Myeloid Leukemia | Other: Non-Interventional |
Study Type : | Observational |
Actual Enrollment : | 1494 participants |
Observational Model: | Cohort |
Time Perspective: | Other |
Official Title: | Studying Interventions for Managing Patients With Chronic Myeloid Leukemia (CML) in Chronic Phase: The 5-Year Prospective Cohort Study (SIMPLICITY) |
Actual Study Start Date : | December 2, 2010 |
Estimated Primary Completion Date : | January 30, 2020 |
Estimated Study Completion Date : | August 30, 2020 |

Group/Cohort | Intervention/treatment |
---|---|
First line TKI treatment: Imatinib
Diagnosed CML patients who receive first line TKI treatment: Imatinib
|
Other: Non-Interventional
Non-Interventional |
First line TKI treatment: Nilotinib
Diagnosed CML patients who receive first line TKI treatment: Nilotinib
|
Other: Non-Interventional
Non-Interventional |
First line TKI treatment: Dasatinib
Diagnosed CML patients who receive first line TKI treatment: Dasatinib
|
Other: Non-Interventional
Non-Interventional |
Imatinib treated patients
Imatinib treated patients if their study index date is between January 2, 2008 and September 30, 2010
|
Other: Non-Interventional
Non-Interventional |
- The rate of Complete Cytogenetic Response [ Time Frame: 12 months ]
- The duration of initial TKI treatment [ Time Frame: 5-years from study index date ]Initiation of first-line TKI, (whether Dasatinib, Imatinib, Nilotinib)
- The rate of discontinuation and treatment changes after initial TKI treatment [ Time Frame: Every 6 months for a follow-up period of 5-years from study index date ]Dates of switches in therapy from initial TKI treatment, Reasons for treatment discontinuation (i.e. side effects, mutations, etc.), Subsequent lines of CML treatments (start and stop dates)
- The rate of best response to therapy (i.e. hematologic, cytogenetic, molecular response) [ Time Frame: Every 6 months for a follow-up period of 5-years from study index date ]Results and dates of: all bone marrow aspirates, blood tests, cytogenetics, Polymerase Chain Reaction (PCR), Fluorescent In-Situ Hybridization (FISH), and Physical exam
- The adherence to treatment [ Time Frame: Every 6 months for a follow-up period of 5-years from study index date ]Morisky Medication Adherence Scale - 8 Items is a validated self-reported measure of medication adherence.
- Impact of first-line treatment options on quality of life [ Time Frame: Every 6 months ]
Questionnaires used for assessment:
Functional Assessment of Cancer Therapy - General (FACT-G), Cancer Therapy Satisfaction Questionnaire (CTSQ), MD Anderson Symptom Inventory - CML (MDASI-CML).
- Non-hematologic side effects from treatment affecting patient quality of life and outcomes [ Time Frame: Every 6 months ]Treatment discontinuations and changes
- Patient satisfaction with CML treatment [ Time Frame: Every 6 months ]Cancer Therapy Satisfaction Questionnaire (CTSQ)
- Patterns of disease monitoring as observed in a real-world setting [ Time Frame: Every 6 months ]MD Anderson Symptom Inventory - CML (MDASI-CML) Questionnaire - disease-specific module of the MDASI7 which is a brief measure of severity and impact of cancer-related symptoms on daily function
- Resource utilization associated with CML management [ Time Frame: Every 6 months ]To evaluate healthcare resource utilization, descriptive statistics will describe real-world disease monitoring patterns, frequency of testing, and resources used for disease management for each treatment cohort.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com.
Inclusion Criteria:
- Newly-diagnosed chronic phase chronic myeloid leukemia (CP-CML) patients who started their first-line Tyrosine Kinase Inhibitor (TKI) treatment on imatinib, dasatinib or nilotinib in accordance with the timelines below
-
18 years or older at time of of CP-CML diagnosis
a) Imatinib Cohorts
- Patients who started their first-line Imatinib treatment between January 2, 2008 and September 30, 2010.Patients fitting this criterion are defined as retrospective Imatinib patients
-
Patients who started their first-line Imatinib treatment on or after October 1, 2010
b) Dasatinib Cohort
-
Patients who started their first-line Dasatinib treatment after the drug was approved in this indication
c) Nilotinib Cohort
- Patients who started their first-line Nilotinib treatment after the drug was approved in this indication
- Patients are also eligible when they have already switched to a subsequent therapy (TKI or other) at the time of enrollment, as long as their first-line and subsequent CML treatment information is available at site for data entry into the study Electronic Case Report Form (eCRF)
- Receiving treatment at medical practice (eg. community-based, office-based, hospital-based, academic setting, oncology center)
Exclusion Criteria:
- Patients who are participating in an interventional trial which may influence the management of their CML disease will be excluded
Discontinuation Criteria:
- Enrolled patients who join an interventional trial which may influence the management of their CML disease will be excluded at the time of entry into the interventional trial

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01244750

United States, Alabama | |
Northwest Alabama Cancer Center | |
Muscle Shoals, Alabama, United States, 35661 | |
United States, Arizona | |
Arizona Oncology Associates, PC - HAL | |
Phoenix, Arizona, United States, 85016 | |
Arizona Oncology Associates, PC - NAHOA | |
Sedona, Arizona, United States, 86336 | |
Arizona Oncology Associates, PC - HOPE | |
Tucson, Arizona, United States, 85704 | |
United States, Arkansas | |
Genesis Cancer Center | |
Hot Springs National Park, Arkansas, United States, 71913 | |
NEA Baptist Clinic | |
Jonesboro, Arkansas, United States, 72401 | |
Little Rock Hematology Oncology Associates | |
Little Rock, Arkansas, United States, 72205 | |
United States, California | |
Pacific Cancer Medical Center, Inc | |
Anaheim, California, United States, 92801 | |
Southwest Cancer Care Medical Group | |
Escondido, California, United States, 92025 | |
Wilshire Oncology Medical Group, Inc | |
Glendora, California, United States, 91741 | |
University of Southern California | |
Los Angeles, California, United States, 90033 | |
St. Joseph's Hospital | |
Orange, California, United States, 92868 | |
PMK Medical Group, Inc. DBA Ventura | |
Oxnard, California, United States, 93030 | |
Stockton Hematology Oncology | |
Stockton, California, United States, 95204 | |
Tahoe Forest Health System Cancer Center | |
Truckee, California, United States, 96160 | |
United States, Colorado | |
Rocky Mountain Cancer Centers | |
Boulder, Colorado, United States, 80303 | |
United States, Connecticut | |
Medical Oncology and Blood Disorders, LLP | |
Manchester, Connecticut, United States, 06040 | |
Stamford Hospital | |
Stamford, Connecticut, United States, 06904 | |
United States, District of Columbia | |
Washington Hospital Center, Washington Cancer Institute | |
Washington, District of Columbia, United States, 20010 | |
George Washington University | |
Washington, District of Columbia, United States, 20237 | |
United States, Florida | |
Hematology And Medical Oncology Of Southern Palm Beach County | |
Boynton Beach, Florida, United States, 33435 | |
Broward Oncology Associates | |
Fort Lauderdale, Florida, United States, 33308 | |
Palm Springs Research Institute | |
Hialeah, Florida, United States, 33012 | |
Baptist Cancer Institute | |
Jacksonville, Florida, United States, 32207 | |
University Of Florida | |
Jacksonville, Florida, United States, 32209 | |
Watson Clinic | |
Lakeland, Florida, United States, 33805 | |
Central Florida Health Alliance | |
Leesburg, Florida, United States, 34748 | |
Baptist Cancer Center | |
Miami, Florida, United States | |
Florida Cancer Specialists | |
New Port Richey, Florida, United States, 34655 | |
Cancer Centers of Florida | |
Orlando, Florida, United States, 32806 | |
Lake County Oncology and Hematology | |
Tavares, Florida, United States, 32778 | |
Space Coast Cancer Center | |
Titusville, Florida, United States, 32796 | |
United States, Georgia | |
Peachtree Hematology-Oncology | |
Atlanta, Georgia, United States, 30318 | |
Emory University | |
Atlanta, Georgia, United States, 30322 | |
Northwest Georgia Oncology Centers, PC | |
Marietta, Georgia, United States, 30060 | |
Georgia Cancer Specialist | |
Sandy Springs, Georgia, United States, 30342 | |
Lewis Hall Singeltary Oncology Center | |
Thomasville, Georgia, United States, 31792 | |
United States, Hawaii | |
OnCare | |
Honolulu, Hawaii, United States, 96813 | |
Straub Clinical & Hospital | |
Honolulu, Hawaii, United States, 96813 | |
Kaiser Permanente Honolulu | |
Honolulu, Hawaii, United States, 96819 | |
United States, Illinois | |
Mahafzah Medical Center | |
Evergreen Park, Illinois, United States, 60805 | |
Delnor Community Hospital | |
Geneva, Illinois, United States, 60134 | |
Orchard Health Care Research | |
Niles, Illinois, United States, 60076 | |
Mid-Illinois Hem/Onc Asoc | |
Normal, Illinois, United States, 61761 | |
North Chicago VA Medical Center | |
North Chicago, Illinois, United States, 60064 | |
Southern Illinois School of Medicine | |
Springfield, Illinois, United States, 62794 | |
Carle Cancer Center | |
Urbana, Illinois, United States, 61801 | |
Central DuPage Hospital | |
Winfield, Illinois, United States, 60190 | |
United States, Indiana | |
Saint John's Cancer Center | |
Anderson, Indiana, United States, 46016 | |
Indiana Blood and Marrow Transplantation | |
Indianapolis, Indiana, United States, 46237 | |
Investigative Clinical Research of Indiana | |
Indianapolis, Indiana, United States, 46260 | |
Horizon Oncology Research, Inc | |
Lafayette, Indiana, United States, 47905 | |
Cancer Care Center, Inc. PC | |
New Albany, Indiana, United States, 47150 | |
United States, Iowa | |
N. Iowa Mercy Cancer Center | |
Mason City, Iowa, United States, 50401 | |
United States, Kansas | |
Hutchinson Clinic | |
Hutchinson, Kansas, United States, 67502 | |
Cotton O'Neil Cancer Center | |
Topeka, Kansas, United States, 66606 | |
Cancer Center of Kansas | |
Wichita, Kansas, United States, 67214 | |
United States, Kentucky | |
Central Baptist Hospital | |
Lexington, Kentucky, United States, 40503 | |
University of Louisville Hospital - Brown Cancer Center | |
Louisville, Kentucky, United States, 40202 | |
Consultants In Blood Disorders | |
Saint Matthews, Kentucky, United States, 40207 | |
United States, Louisiana | |
Ochsner Clinic Foundation | |
New Orleans, Louisiana, United States, 70121 | |
Willis-Knighton Cancer System | |
Shreveport, Louisiana, United States, 71103 | |
United States, Maryland | |
Maryland Oncology Hematology Pa | |
Columbia, Maryland, United States, 21044 | |
Frederick Memorial Hospital | |
Frederick, Maryland, United States, 21701 | |
United States, Massachusetts | |
Sturdy Hematology & Oncology Associates | |
Attleboro, Massachusetts, United States, 02703 | |
Boston VA Healthcare System | |
Boston, Massachusetts, United States, 02130 | |
South Coast Health System | |
Fall River, Massachusetts, United States, 02720 | |
Commonwealth Hematology-Oncology, P.C. | |
Quincy, Massachusetts, United States, 02169 | |
UMass Medical Center | |
Worcester, Massachusetts, United States, 01655 | |
United States, Michigan | |
Cancer & Hematology Centers of Western Michigan | |
Grand Rapids, Michigan, United States, 49503 | |
West Michigan Cancer Center | |
Kalamazoo, Michigan, United States, 49007 | |
Michigan State University | |
Lansing, Michigan, United States, 48910 | |
United States, Mississippi | |
North Mississippi Hematology & Oncology | |
Tupelo, Mississippi, United States, 38801 | |
United States, Missouri | |
St John's Clinic for Cancer and Hematology | |
Springfield, Missouri, United States, 65807 | |
United States, Montana | |
Billings Clinic | |
Billings, Montana, United States, 59101 | |
United States, Nebraska | |
Omaha VAMC | |
Omaha, Nebraska, United States, 68105 | |
United States, New Hampshire | |
Portsmouth Regional Hospital | |
Portsmouth, New Hampshire, United States, 03801 | |
United States, New Jersey | |
Hackensack University Medical Center | |
Hackensack, New Jersey, United States, 07601 | |
Hematology-Oncology Associates of Northern NJ, PA | |
Morristown, New Jersey, United States, 07962 | |
Southern Oncology Hematology | |
Vineland, New Jersey, United States, 08360 | |
United States, New York | |
Montefiore Medical Center / AECOM | |
Bronx, New York, United States, 10467 | |
Broome Oncology | |
Johnson City, New York, United States, 13790 | |
Advanced Oncology | |
New York, New York, United States, 10013 | |
St. Lukes Roosevelt Medical Center | |
New York, New York, United States, 10019 | |
Vassar Brothers Medical Center | |
Poughkeepsie, New York, United States, 12601 | |
Stony Brook University Hospital | |
Stony Brook, New York, United States, 11794 | |
United States, North Carolina | |
Alamance Regional Cancer Center | |
Burlington, North Carolina, United States, 27215 | |
Waverly Hematology Oncology | |
Cary, North Carolina, United States, 27518 | |
Duke University Medical Center | |
Durham, North Carolina, United States, 27710 | |
Gaston Hematology Oncology | |
Gastonia, North Carolina, United States, 28054 | |
East Carolina University | |
Greenville, North Carolina, United States, 27834 | |
United States, Ohio | |
Akron General Medical Center | |
Akron, Ohio, United States, 44302 | |
Gabrail Cancer Center | |
Canton, Ohio, United States, 44718 | |
Signal Point Clinical Research Center, LLC | |
Middletown, Ohio, United States, 45042 | |
Medical Center of Newark | |
Newark, Ohio, United States, 43055 | |
United States, Oklahoma | |
Cancer Care Associates | |
Tulsa, Oklahoma, United States, 74136 | |
United States, Oregon | |
Oregon Health & Science University | |
Portland, Oregon, United States, 97239 | |
Hematology/Oncology Salem LLP | |
Salem, Oregon, United States, 97301 | |
United States, Pennsylvania | |
Lehigh Valley Hospital | |
Allentown, Pennsylvania, United States, 18103 | |
St. Luke's Hospital and Health Network | |
Bethlehem, Pennsylvania, United States, 18015 | |
Medical Oncology Associates of Wyoming Valley, PC | |
Kingston, Pennsylvania, United States, 18704 | |
Lancaster General Health | |
Lancaster, Pennsylvania, United States, 17601 | |
Veterans Research Foundation of Pittsburgh | |
Pittsburgh, Pennsylvania, United States, 15240 | |
Berks Hematology-Oncology | |
West Reading, Pennsylvania, United States, 19611 | |
Geisinger Health System | |
Wilkes-Barre, Pennsylvania, United States, 18711 | |
Cancer Care Association Of York | |
York, Pennsylvania, United States, 17403 | |
United States, Rhode Island | |
Hematology and Oncology Associates of RI | |
Cranston, Rhode Island, United States, 02920 | |
The Cancer Center at Memorial Hospital | |
Pawtucket, Rhode Island, United States, 02860 | |
United States, South Carolina | |
Charleston Cancer Center | |
Charleston, South Carolina, United States, 29406 | |
United States, South Dakota | |
Avera Research Institute | |
Sioux Falls, South Dakota, United States, 57105 | |
Prairie Lakes Healthcare System, Inc | |
Watertown, South Dakota, United States, 57201 | |
United States, Tennessee | |
Tennessee Cancer Specialists | |
Knoxville, Tennessee, United States, 37909 | |
University of Tennessee Medical Center | |
Knoxville, Tennessee, United States, 37920 | |
United States, Texas | |
Texas Oncology | |
Amarillo, Texas, United States, 79106 | |
Texas Oncology - Arlington South | |
Arlington, Texas, United States, 76014 | |
Texas Oncology-Austin North | |
Austin, Texas, United States, 78758 | |
Julie & Ben Rogers Cancer Institute | |
Beaumont, Texas, United States, 77701 | |
Texas Oncology-Medical City Dallas | |
Dallas, Texas, United States, 75230-2510 | |
Texas Oncology-Dallas Presbyterian Hospital | |
Dallas, Texas, United States, 75231 | |
Texas Oncology-Methodist Charlton Cancer Center | |
Dallas, Texas, United States, 75237 | |
MD Anderson Cancer Center | |
Houston, Texas, United States, 77030 | |
Michael DeBakey VA Medical Center | |
Houston, Texas, United States, 77030 | |
Texas Oncology | |
Lewisville, Texas, United States, 75067 | |
Texas Oncology-McAllen South Second | |
McAllen, Texas, United States, 78503 | |
Texas Oncology | |
Mesquite, Texas, United States, 75150 | |
Texas Oncology-Midland Allison Cancer Center | |
Midland, Texas, United States, 79701 | |
Texas Oncology-Odessa West Texas Cancer Center | |
Odessa, Texas, United States, 79761 | |
Texas Oncology | |
Paris, Texas, United States, 75460-5004 | |
North Texas Regional Cancer Center | |
Plano, Texas, United States, 75075 | |
Cancer Care Centers of South Texas | |
San Antonio, Texas, United States, 78217 | |
Texas Oncology | |
Waco, Texas, United States, 76712 | |
United States, Virginia | |
Danville Hematology & Oncology | |
Danville, Virginia, United States, 24541 | |
Hematology Oncology Associates of Fredricksburg | |
Fredericksburg, Virginia, United States, 22408 | |
Peninsula Cancer Institute | |
Newport News, Virginia, United States, 23601 | |
Blue Ridge Cancer Care | |
Roanoke, Virginia, United States, 24014 | |
United States, Washington | |
Swedish Cancer Institute-Eastside Hematology/Oncology | |
Bellevue, Washington, United States, 98005 | |
Providence Cancer Center at Sacred Heart Medical Center | |
Spokane, Washington, United States, 99208 | |
Wenatchee Valley Medical Center | |
Wenatchee, Washington, United States, 98801 | |
Yakima Valley Memorial Hospital/North Star Lodge | |
Yakima, Washington, United States, 98902 | |
United States, West Virginia | |
Charleston Area Medical Center | |
Charleston, West Virginia, United States, 25304 | |
City Hospital - West Virginia University Hospital East | |
Martinsburg, West Virginia, United States, 25401 | |
Wheeling Hospital | |
Wheeling, West Virginia, United States, 26003 | |
United States, Wisconsin | |
Aspirus Regional Cancer Center | |
Wausau, Wisconsin, United States, 53792 | |
France | |
Local Institution | |
Blois cedex, France, 41016 | |
Local Institution | |
Bordeaux, France, 33300 | |
Local Institution | |
Chalon/Saone Cedex, France, 71100 | |
Local Institution | |
Chambéry, France, 73011 | |
Local Institution | |
Le Mans Cedex 09, France, 72037 | |
Local Institution | |
Pierre Benite, France, 69495 | |
Local Institution | |
PRINGY cedex, France, 74374 | |
Germany | |
Local Institution | |
Amberg, Germany, 92224 | |
Local Institution | |
Aschaffenburg, Germany | |
Local Institution | |
Baden-Baden, Germany | |
Local Institution | |
Bamberg, Germany, 96049 | |
Local Institution | |
Berlin, Germany, 12203 | |
Local Institution | |
Berlin, Germany, 13353 | |
Local Institution | |
Bonn, Germany, 53105 | |
Local Institution | |
Bottrop, Germany, 46236 | |
Local Institution | |
Coburg, Germany, 96450 | |
Local Institution | |
Darmstadt, Germany, 64283 | |
Local Institution | |
Essen, Germany, 45136 | |
Local Institution | |
Frankfurt am Main, Germany | |
Local Institution | |
Frankurt am Main, Germany, 60389 | |
Local Institution | |
Greifswald, Germany, 17475 | |
Local Institution | |
Hamm, Germany, 59063 | |
Local Institution | |
Hof, Germany, 95028 | |
Local Institution | |
Idar-Oberstein, Germany, 55743 | |
Local Institution | |
Kaiserslautern, Germany | |
Local Institution | |
Kassel, Germany, 34117 | |
Local Institution | |
Koblenz, Germany, 56068 | |
Local Institution | |
Köln, Germany, 50674 | |
Local Institution | |
Köln, Germany, 50677 | |
Local Institution | |
Landshut, Germany, 84028 | |
Local Institution | |
Lebach, Germany, 66822 | |
Local Institution | |
Leipzig, Germany, 04103 | |
Local Institution | |
Mülheim A. D. Ruhr, Germany, 45468 | |
Local Institution | |
Offenbach, Germany | |
Local Institution | |
Potsdam, Germany, 14467 | |
Local Institution | |
Rostock, Germany, 18057 | |
Local Institution | |
Rötha, Germany, 04571 | |
Local Institution | |
Singen, Germany, 78224 | |
Local Institution | |
Soest, Germany, 59494 | |
Local Institution | |
Ulm, Germany, 89081 | |
Local Institution | |
Velbert, Germany, 42551 | |
Local Institution | |
Weiden, Germany, 92637 | |
Local Institution | |
Würzburg, Germany, 97080 | |
Italy | |
Local Institution | |
Bari, Italy, 70124 | |
Local Institution | |
Brescia, Italy, 25123 | |
Local Institution | |
Brindisi, Italy, 72100 | |
Local Institution | |
Catania, Italy, 95124 | |
Local Institution | |
Florence, Italy, 50134 | |
Local Institution | |
Milano, Italy, 20162 | |
Local Institution | |
Milan, Italy, 20122 | |
Local Institution | |
Modena, Italy, 44100 | |
Local Institution | |
Monza, Italy, 20052 | |
Local Institution | |
Pavia, Italy, 27100 | |
Local Institution | |
Perugia, Italy, 06156 | |
Local Institution | |
Pesaro, Italy, 61122 | |
Local Institution | |
Rionero in Vulture, Italy, 85028 | |
Local Institution | |
Roma, Italy, 00189 | |
Local Institution | |
Rome, Italy, 00161 | |
Local Institution | |
Rome, Italy, 00168 | |
Local Institution | |
Siena, Italy, 53100 | |
Local Institution | |
Terni, Italy, 05100 | |
Local Institution | |
Udine, Italy, 33100 | |
Netherlands | |
Local Institution | |
Hoofddorp, Netherlands, 2134 TM | |
Puerto Rico | |
Puerto Rico Hematology Oncology Group | |
Bayamon, Puerto Rico, 00961 | |
Russian Federation | |
Local Institution | |
Saint-Petersburg, Russian Federation, 197022 | |
Spain | |
Local Institution | |
La Coruña, Spain, 15006 | |
Local Institution | |
Oviedo - Asturias, Spain, 33006 | |
Local Institution | |
Pamplona, Spain, 31008 | |
Local Institution | |
Salamanca, Spain, 37007 | |
Local Institution | |
Santiago De Compostela-A Coruña, Spain, 15706 | |
Local Insitution | |
Toledo, Spain, 45004 |
Study Director: | Bristol-Myers Squibb | Bristol-Myers Squibb |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Bristol-Myers Squibb |
ClinicalTrials.gov Identifier: | NCT01244750 |
Other Study ID Numbers: |
CA180-330 |
First Posted: | November 19, 2010 Key Record Dates |
Last Update Posted: | January 23, 2018 |
Last Verified: | January 2018 |
Chronic Phase - Chronic Myeloid Leukemia |
Leukemia Leukemia, Myeloid Leukemia, Myelogenous, Chronic, BCR-ABL Positive Neoplasms by Histologic Type |
Neoplasms Myeloproliferative Disorders Bone Marrow Diseases Hematologic Diseases |