CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01243424
Recruitment Status : Completed
First Posted : November 18, 2010
Last Update Posted : September 3, 2018
Eli Lilly and Company
Information provided by (Responsible Party):
Boehringer Ingelheim

Brief Summary:
The aim of the study is to investigate the longterm impact on cardiovascular morbidity and mortality, relevant efficacy parameters (e.g., glycaemic parameters) and safety (e.g., weight and hypoglycaemia) of treatment with linagliptin in patients with type 2 diabetes at elevated cardiovascular risk receiving usual care, and compare outcome against glimepiride.

Condition or disease Intervention/treatment Phase
Diabetes Mellitus, Type 2 Drug: linagliptin Drug: glimepiride Drug: linagliptin placebo Drug: glimepride placebo Phase 3

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 6103 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: A Multicentre, International, Randomised, Parallel Group, Double Blind Study to Evaluate Cardiovascular Safety of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk.
Actual Study Start Date : October 26, 2010
Actual Primary Completion Date : August 21, 2018
Actual Study Completion Date : August 21, 2018

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: linagliptin
patient to receive linagliptin or glimepiride placebo overencapsulated tablet QD
Drug: linagliptin
linagliptin tablets 5mg QD

Drug: glimepride placebo
glimepiride placebo

Active Comparator: glimepiride 1-4 mg QD
patient to receive glimepiride 1-4 mg or linagliptin placebo tablet QD
Drug: glimepiride
glimepiride over-encapsulated tablet 1-4 mg QD

Drug: linagliptin placebo
linagliptin placebo

Primary Outcome Measures :
  1. Time to first occurrence of any of the following adjudicated components of the primary composite endpoint: CV death (including fatal stroke and fatal MI), non-fatal MI (excluding silent MI) or non-fatal stroke [ Time Frame: 432 weeks ]

Secondary Outcome Measures :
  1. Time to first occurrence of any of the following adjudicated components of CV death (including fatal stroke and fatal MI), non-fatal MI (excluding silent MI), non-fatal stroke or hospitalisation for unstable angina pectoris [ Time Frame: 432 weeks ]
  2. Proportion of patients on study treatment at study end, that at Final Visit maintain glycemic control (HbA1c <= 7.0%) without need for rescue medication, without any moderate/severe hypoglycaemic episodes and without > 2% weight gain (from V6 on) [ Time Frame: 432 weeks ]
  3. Occurence of any of the adjudicated components of the composite primary and composite first key secondary endpoint. [ Time Frame: 432 weeks ]
  4. Transitions in albuminuria classes between baseline and Final visit. [ Time Frame: 432 weeks ]
  5. Proportion of patients on study treatment at study end, that at Final Visit maintain glycaemic control (HbA1c <= 7.0%) without need for rescue medication and without > 2% weight gain (from V6 on) [ Time Frame: 432 weeks ]
  6. Occurence of and time to composite endpoint of all CEC confirmed adjudicated events [ Time Frame: 432 weeks ]
  7. Change from baseline to Final Visit in diabetes related laboratory parameters: HbA1c, fasting plasma glucose, Total cholesterol, LDL cholesterol, HDL cholesterol, Triglycerides, Creatinine, eGFR (MDRD formula), Urinary Albumin [ Time Frame: 432 weeks ]
  8. Beta-cell function sub-study: The model-calculated insulin secretion rate at a fixed glucose concentration at 4 years as derived from a 3-hour meal tolerance test [ Time Frame: 208 weeks ]
  9. Continuous glucose monitoring sub-study: The glucose variability determined by the change from baseline in the inter-quartile range of diurnal glucose variability to end of study [ Time Frame: 432 weeks ]
  10. Cognition sub-study: Occurrence of accelerated cognitive decline at end of follow-up (a dichotomous outcome measure; presence or absence of accelerated cognitive decline) [ Time Frame: 432 weeks ]

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion criteria:

  1. Type 2 diabetes
  2. Elevated glycosylated haemoglobin (HbA1c): 6.5 - 8.5%, inclusive, if treatment naïve or mono-/dual therapy with metformin and/or an alpha-glucosidase inhibitor; 6.5 - 7.5%, inclusive, if treatment with sulphonylurea/glinide in mono- or dual (with metformin OR an alpha-glucosidase inhibitor) therapy)
  3. Pre-existing cardiovascular disease OR specified diabetes end-organ damage OR age => 70 years OR two or more specified cardiovascular risk factor
  4. BMI =< 45kg/m²
  5. age between >= 40 and =< 85 years
  6. signed and dated written ICF
  7. stable anti-diabetic background for at least 8 wks before study start

Exclusion criteria:

  1. Type 1 diabetes
  2. Treatment with other antidiabetic drugs (e.g. rosiglitazone, pioglitazone, Glucagon-like peptide 1 (GLP-1) analogue/agonists, Dipeptidyl-peptidase IV (DPP-IV) inhibitors or any insulin) prior to informed consent (previous short term use of insulin (up to two weeks) is allowed if taken at least 8 weeks prior informed consent)
  3. treatment with any anti-obesity drug less than 3 months before ICF
  4. uncontrolled hyperglycemia
  5. previous or planned bariatric surgery or intervention
  6. current or planned system corticoid treatment
  7. change in thyroid hormones treatment
  8. acute liver disease or impaired hepatic function
  9. pre-planned coronary artery revascularization within 6 months of ICF
  10. known hypersensitivity to any of the components
  11. Inappropriateness of glimepiride treatment for renal safety issues according to local prescribing information
  12. congestive heart failure class III or IV
  13. acute or chronic metabolic acidosis
  14. hereditary galactose intolerance
  15. alcohol or drug abuse
  16. participation in another trail with IMP given 2 months before IMP start
  17. pre-menopausal women who are nursing or pregnant or of child-bearing potential and not willing to use acceptable method of birth control
  18. patients considered reliable by the investigator
  19. acute coronary syndrome =< 6 wks before ICF
  20. stroke or TIA =< 3 months prior to ICF

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01243424

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United States, Alabama
North Alabama Research Center, LLC
Athens, Alabama, United States, 35611
Alabama Internal Medicine, PC
Birmingham, Alabama, United States, 35235
Cahaba Research, Inc.
Birmingham, Alabama, United States, 35242
Internal Medicine Center, LLC
Mobile, Alabama, United States, 36608
Diagnostic and Medical Clinic
Mobile, Alabama, United States, 36695
Extended Arm Physicians, Inc.
Montgomery, Alabama, United States, 36106
Office of Dr. Terence T. Hart MD
Tuscumbia, Alabama, United States, 35674
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Advanced Clinical Research
Pell City, Alaska, United States, 35128
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Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
Mesa, Arizona, United States, 85203
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
Mesa, Arizona, United States, 85213
Genova Clinical Research
Tucson, Arizona, United States, 85704
Quality of Life Medical & Research Center
Tucson, Arizona, United States, 85712
United States, Arkansas
Northeast Arkansas Baptist Clinic
Jonesboro, Arkansas, United States, 72404
Medical Investigations, Inc
Little Rock, Arkansas, United States, 72205
Aureus Research, Inc
Little Rock, Arkansas, United States, 72211
United States, California
Desert Oasis Healthcare
Bermuda Dunes, California, United States, 92203
Edinger Medical Group and Research Center
Fountain Valley, California, United States, 92708
Clinical Trials of St. Jude Heritage Med. Group
Fullerton, California, United States, 92835
Long Beach Center for Clinical Research
Long Beach, California, United States, 90807
Office of Dr. Richard S. Cherlin
Los Gatos, California, United States, 95032
Providence Clinical Research
North Hollywood, California, United States, 91606
Chaparral Medical Group, Inc
Pomona, California, United States, 91767
ARI Clinical Trials, Inc
Redondo Beach, California, United States, 90277
San Diego Sports Medicine and Family Health Center
San Diego, California, United States, 92120
West Coast Research, LLC
San Ramon, California, United States, 94582
University of California Los Angeles
Sylmar, California, United States, 91342
Metabolic Institute of America
Tarzana, California, United States, 91356
Matrix Research Institute
Tustin, California, United States, 92780
Orange County Research Center
Tustin, California, United States, 92780
Westlake Medical Research
Westlake Village, California, United States, 91361
United States, Colorado
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
Colorado Springs, Colorado, United States, 80909
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
Colorado Springs, Colorado, United States, 80920
United States, Florida
East Coast Medical Associates
Boca Raton, Florida, United States, 33433
Todd Kazdan, DO Family Practice
Davie, Florida, United States, 33314
Century Clinical Research, Inc
Daytona Beach, Florida, United States, 32117
Doral Research Center
Doral, Florida, United States, 33172
Riverside Clinical Research
Edgewater, Florida, United States, 32132
Alan Graff, MD, PA
Fort Lauderdale, Florida, United States, 33309
M & O Clinical Research, LLC
Fort Lauderdale, Florida, United States, 33316
Eastern Research
Hialeah, Florida, United States, 33013
Research in Miami Inc
Hialeah, Florida, United States, 33013
Jacksonville Impotence Treatment Center
Jacksonville, Florida, United States, 32223
East Coast Institute for Research, LLC
Jacksonville, Florida, United States, 32258
Care Partners Clinical Research LLC
Jacksonville, Florida, United States, 32277
Precision Clinical Research, LLC
Lauderdale Lakes, Florida, United States, 33319
Veritas Research Corporation
Miami, Florida, United States, 33126
APF Research, LLC
Miami, Florida, United States, 33134
Swiss Medical Research
Miami, Florida, United States, 33135
University of Miami
Miami, Florida, United States, 33136
South Miami Clinical Research
Miami, Florida, United States, 33143
Well Pharma Medical Research
Miami, Florida, United States, 33143
Advanced Pharma CR, LLC
Miami, Florida, United States, 33147
AppleMed Research Group, LLC
Miami, Florida, United States, 33155
Kendall South Medical Center, Inc
Miami, Florida, United States, 33185
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States, 34652
Advanced Research Institute, Inc
New Port Richey, Florida, United States, 34653
Sunshine Research Center
Opa-locka, Florida, United States, 33054
Diabetes and Endocrine Center of Orlando
Orlando, Florida, United States, 32803
Suncoast Clinical Research
Palm Harbor, Florida, United States, 34684
Misal Khan, MD FRCS, ED, PA
Panama City, Florida, United States, 32401
Iconic Clinical Trials
Pembroke Pines, Florida, United States, 33024
Gulf Region Clinical Research Institute
Pensacola, Florida, United States, 32514
St. John's Center for Clinical Research
Ponte Vedra Beach, Florida, United States, 32081
Metabolic Research Institute
West Palm Beach, Florida, United States, 33401
United States, Georgia
PMI Health Research Group
Atlanta, Georgia, United States, 30312
Atlanta Diabetes Associates
Atlanta, Georgia, United States, 30318
Albert F. Johary MD, PC
Dunwoody, Georgia, United States, 30338
Georgia Clinical Research, LLC
Snellville, Georgia, United States, 30078
United States, Idaho
Hayden Lake Family Physicians
Hayden Lake, Idaho, United States, 83835
Boise Kidney and Hypertension Institute
Meridian, Idaho, United States, 83642
United States, Illinois
Suburban Clinical Research
Bolingbrook, Illinois, United States, 60490
Cedar-Crosse Research Center
Chicago, Illinois, United States, 60607
John H. Stroger Jr. Hospital of Cook Country
Chicago, Illinois, United States, 60612
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Chicago, Illinois, United States, 60616
Pharmakon Inc
Evergreen Park, Illinois, United States, 60805
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American Health Network
Avon, Indiana, United States, 46123
Investigators Research Group, LLC
Brownsburg, Indiana, United States, 46112
American Health Network of Indiana, LLC
Franklin, Indiana, United States, 46131
Mapleton Medical Center
Indianapolis, Indiana, United States, 46205
American Health Network, LLC
Indianapolis, Indiana, United States, 46254
McKinley Research, LLC
Mishawaka, Indiana, United States, 46545
American Health Network of Indiana, LLC
Muncie, Indiana, United States, 47304
United States, Kentucky
MCM Clinical Research, LLC
Florence, Kentucky, United States, 41042
Kentucky Diabetes Endocrinology Center
Lexington, Kentucky, United States, 40503
Four Rivers Clinical Research, Inc
Paducah, Kentucky, United States, 42003
United States, Louisiana
Crescent City Clinical Research
Metairie, Louisiana, United States, 70006
United States, Maine
Acadia Clinical Research, LLC
Bangor, Maine, United States, 04401
United States, Maryland
Office of Dr. Stephen R. Smith, MD
Baltimore, Maryland, United States, 21234
Endocrine and Metabolic Consultants
Rockville, Maryland, United States, 20852
United States, Massachusetts
Tristan Medical Enterprises, PC dba Regeneris
North Attleboro, Massachusetts, United States, 02760
United States, Michigan
ClinSite, LLC
Canton, Michigan, United States, 48187
Apex Medical Research, AMR Inc
Flint, Michigan, United States, 48504
Westside Family Medical Center, PC
Kalamazoo, Michigan, United States, 49009
Tri City Medical Centers, PC
Livonia, Michigan, United States, 48152
KMED Research
Saint Clair Shores, Michigan, United States, 48081
Tri-County Research, Inc
Sterling Heights, Michigan, United States, 48310
Medical Research Associates
Traverse City, Michigan, United States, 49684
Oakland Medical Research Center
Troy, Michigan, United States, 48085
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Park Nicollet Institute
Minneapolis, Minnesota, United States, 55416
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The Center for Clinical Trials, Inc.
Biloxi, Mississippi, United States, 39531
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Mercy Health Research
Saint Louis, Missouri, United States, 63141
United States, Nebraska
Quality Clinical Research
Omaha, Nebraska, United States, 68114
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Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
Henderson, Nevada, United States, 89052
Clinical Research of South Nevada
Las Vegas, Nevada, United States, 89121
Palm Medical Research Center
Las Vegas, Nevada, United States, 89148
United States, New Jersey
Atco Medical Associates, PC
Atco, New Jersey, United States, 08004
Summit Medical Group
Clifton, New Jersey, United States, 07012
USMA Clinical Research
Elizabeth, New Jersey, United States, 07201
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Elizabeth, New Jersey, United States, 07202
United States, New York
Albany Medical Center / Albany Medical College
Albany, New York, United States, 12206
Endocrine Associates of Long Island, PC
Smithtown, New York, United States, 11787
Southgate Medical Group/ Southgate Medical Park
West Seneca, New York, United States, 14224
United States, North Carolina
OnSite Clinical Solutions, LLC
Asheville, North Carolina, United States, 28801
Kernodle Clinic West
Burlington, North Carolina, United States, 27215
The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27517
Internal Medicine Research
Charlotte, North Carolina, United States, 28204
Gaffney Health Services
Charlotte, North Carolina, United States, 28205
Durham Internal Medicine Associates
Durham, North Carolina, United States, 27704
Sentara Family Medicine
Elizabeth City, North Carolina, United States, 27909
PMG Research of Raleigh, LLC
Raleigh, North Carolina, United States, 27609
Carolina Research Center, Inc
Shelby, North Carolina, United States, 28150
Piedmont Healthcare
Statesville, North Carolina, United States, 28625
PMG Research of Wilmington, LLC
Wilmington, North Carolina, United States, 28401
United States, Ohio
Community Health Care of Manchester
Akron, Ohio, United States, 44319
Community Medical Associates, LLC
Austintown, Ohio, United States, 44515
Harrison Community Research Center
Cadiz, Ohio, United States, 43907
Medical Frontiers, LLC
Carlisle, Ohio, United States, 45005
Genoa Medical Center
Genoa, Ohio, United States, 43430
Office of Dr. Craig S. Thompson, MD, LLC
Marion, Ohio, United States, 43302
RAS Health Limited
Marion, Ohio, United States, 43302
Advanced Medical Research, LLC
Maumee, Ohio, United States, 43537
Pharmacotherapy Research Associates, Inc
Zanesville, Ohio, United States, 43701
United States, Oklahoma
Infinity Research Group, LLC
Oklahoma City, Oklahoma, United States, 73103
Castlerock Clinical Research Consultants, LLC
Tulsa, Oklahoma, United States, 74136
United States, Oregon
Oregon Medical Group
Eugene, Oregon, United States, 97401
United States, Pennsylvania
Harleysville Medical Associates
Harleysville, Pennsylvania, United States, 19438
Detweiler Family Medicine & Associates, PC
Lansdale, Pennsylvania, United States, 19446
Temple University School of Medicine
Philadelphia, Pennsylvania, United States, 19140
Warminster Medical Associates, PC
Warminster, Pennsylvania, United States, 18974
United States, Rhode Island
New England Center for Clinical Research, Inc
Cranston, Rhode Island, United States, 02920
United States, South Carolina
Hartwell Research Group, LLC
Anderson, South Carolina, United States, 29621
Paris View Family Practice
Greenville, South Carolina, United States, 29601
Mountain View Clinical Research
Greer, South Carolina, United States, 29651
South Carolina Nephrology and Hypertension Center, Inc
Orangeburg, South Carolina, United States, 29118
Carolina Diabetes & Kidney Center
Sumter, South Carolina, United States, 29150
United States, Tennessee
PMG Research of Bristol
Bristol, Tennessee, United States, 37620
University Diabetes and Endocrine Consultants
Chattanooga, Tennessee, United States, 37411
University of Tennessee
Memphis, Tennessee, United States, 38163
Trinity Clinical Research, LLC
Tullahoma, Tennessee, United States, 37388
United States, Texas
KRK Medical Research
Arlington, Texas, United States, 76012
Austin Center for Clinical Research
Austin, Texas, United States, 78758
Punzi Medical Center
Carrollton, Texas, United States, 75006
Dallas Diabetes and Endocrine Center
Dallas, Texas, United States, 75230
Baylor Endocrine Center
Dallas, Texas, United States, 75246
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390-8858
Jacon Medical Research Associates, LLC
Houston, Texas, United States, 77030
JVC Family Medicine
Houston, Texas, United States, 77040
Clinical Trial Network
Houston, Texas, United States, 77074
Endocrine and Psychiastry Center
Houston, Texas, United States, 77095
Pioneer Research Solutions, Inc.
Houston, Texas, United States, 77099
Midland Clinical Research Center
Midland, Texas, United States, 79707
Hill Country Medical Associates
New Braunfels, Texas, United States, 78130
Naidu Clinic
Odessa, Texas, United States, 79761
The Methodist Hospital d/b/a HMRI CCAT at Pearland
Pearland, Texas, United States, 77584
Village Health Partners
Plano, Texas, United States, 75024
Sun Research Institute
San Antonio, Texas, United States, 78215
Northeast Clinical Research of San Antonio, LLC
Schertz, Texas, United States, 78154
Kenneth Otah and Associates
Sugar Land, Texas, United States, 77478
United States, Utah
PHS Clinical Trials
Midvale, Utah, United States, 84047
Highland Clinical Research
Salt Lake City, Utah, United States, 84124
United States, Virginia
Burke Internal Medicine and Research
Burke, Virginia, United States, 22015
Ettrick Health Center
Ettrick, Virginia, United States, 23803
Manassas Clinical Research Center
Manassas, Virginia, United States, 20110
Clinical Research Partners, LLC
Richmond, Virginia, United States, 23220
Richmond Family Practice
Richmond, Virginia, United States, 23220
United States, Washington
Larry D Stonesifer, MD Inc., PS
Federal Way, Washington, United States, 98003
Premier Clinical Research
Spokane, Washington, United States, 99204
Instituto de Investigaciones Clínicas de Bahía Blanca
Bahía Blanca, Argentina, B8000FTD
Caba, Argentina, C1119ACN
Caba, Argentina, C1440AAD
Instituto Médico Especializado
Capital Federal, Argentina, C1405BCH
Consultorios Asociados de Endocrinología e Invest Clínica
Capital Federal, Argentina, C1425AGC
IPAC - Clínica Privada Caraffa SRL
Cordoba, Argentina, X5008KKF
Instituto Cardiovascular de Corrientes Juana Francisca Cabra
Corrientes, Argentina, W3400AMZ
Córdoba, Argentina, X5000BNB
Hospital Italiano de La Plata
La Plata, Argentina, B1900AWT
Mendoza, Argentina, M5500EVJ
Instituto de Investigaciones Clinicas de Rosario
Rosario, Argentina, S2000CVD
Instituto de Hematología y Medicina Clínica Dr. Rubén Davoli
Rosario, Argentina, S2000CXP
Hospital San Bernardo
Salta, Argentina, A4406CLA
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, Argentina, T4000ICL
Instituto de Investigaciones Biomédicas
Santa Fe, Argentina, S3000FNF
Centro de Investigaciones Clínicas del Litoral
Santa Fe, Argentina, S3000SWO
Australia, Queensland
Royal Brisbane & Women's Hospital-Endocrinology
Herston, Queensland, Australia, 4029
Logan Hospital
Meadowbrook, Queensland, Australia, 4131
Australia, South Australia
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Australia, Victoria
Eastern Clinical Research Unit
East Ringwood, Victoria, Australia, 3135
Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Blankenberge - PRAC Vileyn, Geert
Blankenberge, Belgium, 8370
Bonheiden - HOSP Imelda
Bonheiden, Belgium, 2820
De Pinte - PRAC Hollanders, Geert
De Pinte, Belgium, 9840
Retie - PRAC De Vos, Axel
Dessel, Belgium, 2480
Deurne - PRAC Heyvaert, Frank
Deurne, Belgium, 2100
Deurne - PRAC Verelst, Joost
Deurne, Belgium, 2100
Genk - PRAC Vernijns, J.
Genk, Belgium, 3600
Gozée - PRAC De Meulemeester, Marc
Gozée, Belgium, 6534
Hasselt - PRAC Vantroyen, Daniel
Hasselt, Belgium, 3500
Herent - PRAC Denolf, Bart
Herent, Belgium, 3020
Linkebeek - PRAC Maury, Olivier
Linkebeek, Belgium, 1630
Moorsel - PRAC Van Mulders, N.
Moorsel, Belgium, 9310
Natoye - PRAC Balthazar, Y.
Natoye, Belgium, 5360
Tremelo - PRAC Vermeersch, Lode
Tremelo, Belgium, 3210
Hospital Universitário João de Barros Barreto
Belém, Brazil, 66073-000
Universidade Federal do Paraná
Curitiba, Brazil, 80060-900
Hospital Geral de Goiânia Alberto Rassi
Goiânia, Brazil, 74043-110
Centro de Pesquisas Clínicas Ltda
Higienópolis, Brazil, 01244-030
Centro de Estudos em Diabetes e Hipertensão
Joaquim Távora, Brazil, 60115-282
Irmandade Santa Casa de Misericordia de Porto Alegre
Porto Alegre, Brazil, 90020-090
Centro de Pesquisas em Diabetes
Porto Alegre, Brazil, 90035-170
Instituto Estadual de Diabetes e Endocrinologia
Río de Janeiro, Brazil, 20211-340
Irmandade da Santa Casa de Misericórdia de São Paulo - IPEC - Instituto de Pesquisa Clínica
Santa Cecília, Brazil, 01221-020
Instituto de Molestias Cardiovasculares - IMC
São José do Rio Preto, Brazil, 15015-210
Hospital das Clinicas da FMUSP
São Paulo, Brazil, 05403-900
Hospital do Rim e Hipertensão - UNIFESP
Vila Clementino, Brazil, 04025-011
Univ.Multiprofile Hospital "Dr. Georgy Stranski" EAD, Pleven
Pleven, Bulgaria, 5800
Multiprofile Hospital for Active Treatment
Sofia, Bulgaria, 1431
Multiprofile Hospital for Active Treatment "Zaritza Johanna"
Sofia, Bulgaria, 1527
Military Medical Academy, Clin. Endocrinology & Metab. Dis.
Sofia, Bulgaria, 1606
MHAT Prof Stoyan Kirkovich AD
Stara Zagora, Bulgaria, 6000
Canada, Migration Data
IUCPQ (Laval University)
Quebec, Migration Data, Canada, G1V 4G5
Canada, Newfoundland and Labrador
First Line Medical Services Ltd.
St. John's, Newfoundland and Labrador, Canada, A1E 2C2
Topsail Road Medical Clinic
St. John's, Newfoundland and Labrador, Canada, A1E 2E2
Canada, Ontario
Cambridge Cardiac Care Inc.
Cambridge, Ontario, Canada, N1R 6V6
Hamilton Medical Research Group
Hamilton, Ontario, Canada, L8M 1K7
SKDS Research Incorporated
Newmarket, Ontario, Canada, L3Y 5G8
Wilderman Medical Clinic
Thornhill, Ontario, Canada, L4J 1W3
St. Michael's Hospital
Toronto, Ontario, Canada, M5C 2T2
Albion Finch Medical Centre
Toronto, Ontario, Canada, M9V 4B4
Canada, Prince Edward Island
Kings County Medical Centre
Montague, Prince Edward Island, Canada, C0A 1R0
Canada, Quebec
Dynamik Research
Pointe Claire, Quebec, Canada, H9R 3J1
Consulta Privada Maria Loreto Aguirre Coveña
Providencia, Chile, 7500010
Hospital de Servicios Médicos Godoy Ltda
Providencia, Chile
Centro Medico Antulawen
Temuco, Chile
Hospital Naval Almirante Nef
Viña del Mar, Chile
Barranquilla, Colombia
Centro Cientifico Asistencial Jose Luis Accini
Barranquilla, Colombia
Fundacion del Caribe de Investigacion Biomedica
Barranquilla, Colombia
Endocare Research Institute
Bogota, Colombia
Dexa Diabetes Servicios Médicos Ltda
Bogotá, Colombia
UNIENDO Unidad Integral de Endocrinologia
Bogotá, Colombia
Centro cardiovascular Aristides
Cartagena, Colombia
centro de Diagnostico Cardiologico para la Investigacion Bio
Cartagena, Colombia
Fundacion Cardiovascular de Colombia
El Bosque, Colombia
Fundación Oftalmologica de Santander
El Bosque, Colombia
Fundación Centro de Investigaciones Biomédicas Riescard
Tolima, Colombia
Internal & Diabetology Ambulance, Jablonec nad Nisou
Jablonec nad Nisou, Czechia, 466 01
Diabetology & Internal Ambulance
Olomouc-Lazce, Czechia, 779 00
Internal & Diabetology Ambulance Dr. Vrkoc, Ostrava
Ostrava, Czechia, 702 00
Cardiology ambulance, Plzen
Plzen, Czechia, 301 00
ResTrial s.r.o.
Praha 8, Czechia, 181 00
Diebetology internal Ambulance
Praha, Czechia, 101 00
Internal & Diabetology Ambulance, Prostejov
Prostejov, Czechia, 796 01
Hospital Strakonice, Internal Department
Strakonice, Czechia, 386 29
Diabetesklinikka, Mehiläinen Töölö
Helsinki, Finland, 00260
Lääkärikeskus Ite
Joensuu, Finland, 80100
Lääkärikeskus Aava Kerava
Kerava, Finland, 04200
Kokkolan Lääkärikeskus
Kokkola, Finland, 67100
Kuopio, Finland, FI-70100
Terveystalo Oulu, Diapolis
Oulu, Finland, FI-90100
Turku, Finland, FI-20520
CAB Hell M, MG, Behren Les Forbach
Behren Les Forbach, France, 57460
HOP Haut Levèque, Diabéto, Pessac
Bordeaux, France, 33075
CAB Lemarie B, MG, Bourg des Cptes
Bourg des Comptes, France, 35890
CAB Cadinot Dr D, Broglie
Broglie, France, 27270
CAB Breton Dr Nicolas
Béziers, France, 34500
CAB Ferrier R, MG, Cannes
Cannes, France, 06400
CAB Jordan E, MG, Carbonne
Carbonne, France, 31390
CAB Merlin P, MG Castets
Castets, France, 40260
CAB Fonteny R, MG, Chartres
Chartres, France, 28000
CAB Fournier P, MG, Chartres
Chartres, France, 28000
CAB Martocq G, MG, Cournonterral
Cournonterral, France, 34660
HOP, Fort de France, Fort de France
Fort De France, France, 97261
CAB Le Mouel S, MG, Hinx
Hinx, France, 40180
CAB Pholsena, MG, La Réunion
La Reunion, France, 97410
CAB Bismuth M
Labarthe sur Leze, France, 31860
CAB Zimmermann D
Louvigne De Bie, France, 35680
CAB Mainetti P, MG, Maintenon
Maintenon, France, 28130
CAB Barucq F, MG, Orthez
Orthez, France, 64300
CAB Mostephai M
Orthez, France, 64300
CAB Cassagnes JL, MG, Palau Del Vidre
Palau Del Vidre, France, 66690
CAB Mercey Y, MG, St Genies des Fontaines
Saint Genies Des Fontaines, France, 66740
Hop St Dié des Vosges, Diabéto, St Dié des Vosges
St Dié des Vosges Cedex, France, 88187
CAB Bonneau D, MG, Thouars
Thouars, France, 79100
CAB Morel H, MG, Tilly sur Seulles
Tilly sur Seulles, France, 14250
Unimed Ajara LLC, Private Practice
Batumi, Georgia, 6004
Central Hospital LTD 'Gormedi', Gori
Gori, Georgia, 1400
L&J Clinic, Kutaisi
Kutaisi, Georgia, 4600
EC Cardiology Clinic,Tbilisi
Tbilisi, Georgia, 0144
National Center for Diabetes Research Ltd., Tbilisi
Tbilisi, Georgia, 0159
National Institute of Endocrinology, Tbilisi
Tbilisi, Georgia, 0159
Zhordania Institute of Human Reproduction, Tbilisi
Tbilisi, Georgia, 0159
Medical Centre Medelite Ltd., Tbilisi
Tbilisi, Georgia, 0177
Chemotherapy & Immunotherapy Clinic 'Medulla', Tbilisi
Tbilisi, Georgia, 0186
JSC 'Curatio'
Zugdidi, Georgia, 2100
Universitätsklinikum Aachen, AöR
Aachen, Germany, 52074
Studienzentrum Klausmann
Aschaffenburg, Germany, 63739
Gemeinschaftspraxis, Asslar
Asslar, Germany, 35614
Diabetes Schwerpunktpraxis
Bad Nauheim, Germany, 61231
Praxis Dr. Naumburger, Berlin
Berlin, Germany, 10409
emovis GmbH
Berlin, Germany, 10629
Praxis Dr. Rieker, Berlin
Berlin, Germany, 10789
IFG Institut für Gesundheitsförderung GmbH
Berlin, Germany, 12621
MVZ DaVita Dormagen GmbH
Dormagen- Hackenbroich, Germany, 41540
Praxis Dr. Busch, Dortmund
Dortmund, Germany, 44137
Dresden, Germany, 01307
Praxis Dr. Schlecht, Eisenach
Eisenach, Germany, 99817
ZKS Südbrandenburg GmbH
Elsterwerda, Germany, 04910
Praxis Dr. Huptas, Essen
Essen, Germany, 45307
Praxis Dr. Schmidt, Flörsheim
Flörsheim, Germany, 65439
Institut für Stoffwechselforschung, Frankfurt
Frankfurt, Germany, 60322
Praxis Dr. Groeneveld, Furth im Wald
Furth im Wald, Germany, 93437
Praxis Dr. Kohlhas, Gebhardshain
Gebhardshain, Germany, 57580
Praxis Dr. Samer, Haag
Haag, Germany, 83527
Klinische Forschung Management & Services GmbH
Hamburg, Germany, 20253
Diabetologische Schwerpunktpraxis
Hamburg, Germany, 21073
Praxis Dr. Burkhardt, Hamburg
Hamburg, Germany, 22335
Diabeteszentrum Alstertal, Hamburg
Hamburg, Germany, 22391
Praxis Dr. Herrmann, Hatten
Kirchhatten, Germany, 26209
Dünnwaldpraxis, Köln
Köln, Germany, 51069
Praxis Dr. Klein, Künzing
Künzing, Germany, 94550
Praxis Dr. Nischik, Leipzig
Leipzig, Germany, 04109
Praxis Dr. Kropp, Lübeck
Lübeck, Germany, 23554
PFÜTZNER Science & Health Institute GmbH
Mainz, Germany, 55128
Diabetologische Schwerpunktpraxis
Münster, Germany, 48153
Praxis Dr. Böckmann
Neumünster, Germany, 24534
Praxis Dr. Hilgenberg
Rehburg-Loccum, Germany, 31547
Praxis Dr. Naudts, Rodgau
Rodgau/Dudenhofen, Germany, 63110
Praxis Dr. Hirschhäuser
Saarbrücken, Germany, 66121
Praxis Dr. Segner, St. Ingberg
Saint Ingbert / Oberwürzbach, Germany, 66386
Praxis Dr. Herrmann
Schwabenheim, Germany, 55270
Praxis Dr. Dietlein
Stadtbergen, Germany, 86391
Praxis Dr. Sauter
Wangen, Germany, 88239
Schwerpunktpraxis Diabetologie
Zwenkau, Germany, 04442
General Hospital of Athens Evangelismos
Athens, Greece, 10676
General University Hospital "Attikon"
Haidari, Athens, Greece, 12410
Univ. Gen. Hosp. of Ioannina
Ioannina, Greece, 45500
General Hospital "Amalia Fleming"
Melissia, Athens, Greece, 15127
General Hospital "Amalia Fleming" 1st Pathology Department
Melissia, Athens, Greece
General Hospital of Nikaia
Nikaia, Greece, 18484
University General Hospital of Thessaloniki AHEPA
Thessaloniki, Greece, 54636
General Hopsital of Thessaloniki "Ippokrateio"
Thessaloniki, Greece, 54642
Kliniki Thermi
Thessaloniki, Greece, 57001
Hong Kong
Alice Ho Miu Ling Nethersole Hospital
Hong Kong, Hong Kong
Prince of Wales Hospital
Hong Kong, Hong Kong
Queen Mary Hospital
Hong Kong, Hong Kong
Imre Magyar Hospital, Ajka
Ajka, Hungary, 8400
Lausmed Kft. Outpatient Unit of Internal Medicine
Baja, Hungary, 6500
Karolyi Sandor Hospital, Budapest
Budapest, Hungary, 1041
Bekes County Pandy Kalman Hospital
Gyula, Hungary, 5700
Erzsebet Hospital, Hodmezövasarhely
Hódmezövásárhely, Hungary, 6800
Dr. Samuel Diosszilagyi Hospital and Outpatient Clinic, Mako
Mako, Hungary, 6900
TaNa Med Kft.
Mosonmagyarovar, Hungary, 9200
Grof Esterhazy Hospital and Outpatient Clinic
Papa, Hungary, 8500
Tolna County Balassa Janos Hospital
Szekszard, Hungary, 7100
Shree Krishna Hospital and Heart Care Centre, Ahmedabad
Ahmedabad, India, 380052
CIIGMA Institute of Medical Sciences Pvt Ltd
Aurangabad, India, 431001
MS Ramaiah Memorial Hospital,
Bangalore, Karnataka, India, 560054
Diabetes care and research centre
Bangalore, India, 560010
Manipal Hospital
Bangalore, India, 560017
Bangalore Diabetes Centre (BDC)- Medisys Clinical Research
Bangalore, India, 560043
Belgaum Diabetes Centre, Belgaum
Belgaum, India, 590001
Swamy Diabetes Centre
Chennai, India, 600 028
Apollo Hospitals
Chennai, India, 600010
M V Hospital For Diabetes and Diabetes Research Centre
Chennai, India, 600013
Dr. Mohans Diabetes Speciality Centre
Chennai, India, 600086
Kovai Diabetes Speciality Centre & Hospital
Coimbatore, India, 641009
TOTALL Diabetes Hormone Institute
Indore, India, 452010
Diabetes Thyroid and Endocrine Centre
Jaipur, India, 302 006
Diamed Clinical Research Services Pvt. Ltd.
Jaipur, India, 302016
Grant Medical Foundation, Ruby Hall Clinic
Maharashtra, India, 411001
K.G.N. Diabetes and Endocrine Centre
Mumbai, Maharastra, India, 400008
Global Hospital- Superspeciality & Transplant Centre
Mumbai, India, 400012
Mumbai, India, 400014
Sunil's Diabetes care and Research Centre
Nagpur, India, 440 010
Jahingir Clinical Development Centre
Pune, India, 411001
Deshmukh Clinic
Pune, India, 411030
Diabetes Care Center
Thiruvananthapuram, India, 695 010
Yalamanchi Hospitals & Research Centres Pvt Ltd.
Vijayawada, India, 520 002
The Red House Family Practice
Co. Cork, Ireland, CORK
Connolly Hospital Blanchardstown
Dublin, Ireland, 15
The Palms GP Surgery
Gorey, Ireland, Wexford
Fethard-on-Sea Medical Practice
Wexford, Ireland, Wexford
Barzilai Medical Center
Ashkelon, Israel, 78278
Rambam Medical Center
Haifa, Israel, 31096
Edith Wolfson Medical Center, Diabetic Unit, Holon
Holon, Israel, 58100
Hadassah Medical Center, Ein-Karem
Jerusalem, Israel, 91120
Western Galilee Hospital
Nahariya, Israel, 22100
The Chaim Sheba Medical Center Tel Hashomer
Tel Hashomer, Israel, 52621
Sourasky Medical Center
Tel-Aviv, Israel, 64239
Ospedale "SS. Trinità"
Cagliari, Italy, 09100
Policlinico Universitario Mater Domini, Universita di Catanzaro
Catanzaro, Italy, 88100
Policlinico San Martino
Genova, Italy, 16132
Ospedale di Guastalla
Guastalla (RE), Italy, 42016
A.O.U.Policlinico G.Martino
Messina, Italy, 98125
Fondazione Centro San Raffaele del Monte Tabor
Milano, Italy, 20132
Ospedale S. Pertini
Roma, Italy, 00100
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
Roma, Italy, 00189
IRCCS Gruppo Multimedica
Sesto San Giovanni (MI), Italy, 20099
Daishinkai Medical Corporation Ookuma Hospital
Aichi, Nagoya, Japan, 462-0825
Chibanishi General Hospital
Chiba, Matsudo, Japan, 270-2251
New Tokyo Heart Clinic
Chiba, Matsudo, Japan, 271-0077
Kashinoki I.M. Clinic, Fukushima, I.M.
Fukushima, Date, Japan, 960-0418
Japan Community Health care Organization Nihonmatsu Hospital
Fukushima, Nihonmatsu, Japan, 964-8501
Iwase General Hospital
Fukushima, Sukagawa, Japan, 962-8503
Iryohojinshadan Sasaki Clinic
Hyogo, Amagasaki, Japan, 660-0827
Takasagoseibu Hospital
Hyogo, Takasago, Japan, 676-0812
Kanagawa Cardiovascular and Respiratory Center
Kanagawa, Yokohama, Japan, 236-0051
Jinnouchi Clinic Diabetes Care Center
Kumamoto, Kumamoto, Japan, 862-0976
Kumamoto Rosai Hospital
Kumamoto, Yatsushiro, Japan, 866-8533
Koga General Hospital
Miyazaki, Miyazaki, Japan, 880-0041
Saitama Medical Cooperative Association Hanyu General Hospital
Saitama, Hanyu, Japan, 348-0045
Nihon University Itabashi Hospital
Tokyo, Itabashi-ku, Japan, 173-8610
Korea, Republic of
Korea University Ansan Hospital
Ansan, Korea, Republic of, 15355
Inje University Busan Paik Hospital
Busan, Korea, Republic of, 614-735
Keimyung University Dongsan Medical Center
Daegu, Korea, Republic of, 700-712
National Health Insurance Service Ilsan Hospital
Goyang, Korea, Republic of, 410-719
Dongguk University Ilsan Hospital
Goyang, Korea, Republic of, 410-773
Inje University Ilsan Paik Hospital
Goyang, Korea, Republic of, 411-706
Chonbuk National University Hospital
Jeonju, Korea, Republic of, 561-712
Pusan National Univ. Hosp
Pusan, Korea, Republic of, 602-739
Seoul National University Bundang Hospital
Seongnam, Korea, Republic of, 463-707
Korea University Anam Hospital
Seoul, Korea, Republic of, 02841
Korea University Guro Hospital
Seoul, Korea, Republic of, 08308
Kangdong Sacred Heart Hospital
Seoul, Korea, Republic of, 134-701
Ajou University Hospital
Suwon, Korea, Republic of, 443-380
Wonju Severance Christian Hosp
Wonju, Korea, Republic of, 220-701
Pusan National University Yangsan Hospital
Yangsan, Korea, Republic of, 626-770
Monash University
Johor Bahru, Johor, Malaysia, 80100
Hospital University Sains Malaysia
Kota Bharu, Malaysia, 16150
Hospital Kuala Lumpur
Kuala Lumpur, Malaysia, 50586
University Malaya Medical Centre
Kuala Lumpur, Malaysia, 59100
Hospital Tengku Ampuan Afzan
Kuantan, Malaysia, 25100
Hospital Melaka
Melaka, Malaysia, 75400
Penang Medical College
Penang, Malaysia, 10450
Hospital Taiping
Taiping, Malaysia, 34000
Hospital General de Acapulco
Acapulco, Mexico, 39570
Centro de Investigacion Cardiometabolica de Aguascalientes
Aguascalientes, Mexico, 20234
Instituto Nacional de Cardiologia Ignacio Chavez
Distrito Federal, Mexico, 14080
Unidad de Investigacion Clinica Cardiometabolica de Occident
Guadalajara, Mexico, 44150
Hospital Universitario Dr Jose Eleuterio Gonzalez
Monterrey, Mexico, 64460
Huisartspraktijk Emmers
's-hertogenbosch, Netherlands, 5235 KG
Almere, Netherlands, 1311 RL
Academisch Medisch Centrum (AMC)
Amsterdam, Netherlands, 1105 AZ
Rode Kruis Ziekenhuis Beverwijk
Beverwijk, Netherlands, 1942 LE
Andromed Breda
Breda, Netherlands, 4811 SW
Noordwest Ziekenhuisgroep, location Den Helder
Den Helder, Netherlands, 1782 GZ
Andromed Eindhoven
Eindhoven, Netherlands, 5611 NV
Andromed Noord
Groningen, Netherlands, 9711 SG
Vasculair Onderzoek Centrum
Hoorn, Netherlands, 1624 NP
Maastricht Universitair Medisch Centrum
Maastricht, Netherlands, 6229 HX
Andromed Rotterdam
Rotterdam, Netherlands, 3039 BD
Rotterdam Research Institute
Rotterdam, Netherlands, 3039 BD
Ikazia Ziekenhuis
Rotterdam, Netherlands, 3083 AN
Antonius Ziekenhuis
Sneek, Netherlands, 8601 ZK
Andromed Oost
Velp, Netherlands, 6883 ES
Andromed Leiden-Zoetermeer
Zoetermeer, Netherlands, 2724 EK
New Zealand
Christchurch Hospital
Christchurch, New Zealand, 4710
RMC Medical Research Ltd
Dunedin, New Zealand, 9012
P3 Research, Wellington
Newtown Wellington NZ, New Zealand, 6021
P3 Research, Promed House
Tauranga, New Zealand, 3110
Bodø Legesenter AS, avd. for med. studier
Bodø, Norway, N-8001
Medi 3 Innlandet AS, avd Elverum
Elverum, Norway, N-2408
Vestre Viken HF, Bærum sykehus
Gjettum, Norway, N-1346
M3 Helse AS
Hamar, Norway, N-2317
Bylegene SA
Jessheim, Norway, N-2050
Lierskogen, Norway, N-3420
Rådhuset Spesialistsenter
Oslo, Norway, N-0160
Sandvika Spesialistsenter
Sandvika, Norway, N-1337
Grålum Legesenter
Sarpsborg, Norway, N-1727
Forusakutten - Kolibri Medical, Avd. Stavanger
Stavanger, Norway, N-4005
Medi 3 AS
Ålesund, Norway, N-6002
Instituto Delgado de Investigacion Medica
Arequipa, Peru, LIMA 54
Clinica San Pedro
Huacho, Peru
Hospital Nacional Dos de Mayo
Lima, Peru, 01
Clinica Internacional
Lima, Peru, LIMA 1
Centro de Investigaciones Médicas METABOLICARE SAC
Lima, Peru, Lima 27
Clinica San Gabriel
Lima, Peru, Lima 32
Centro De Especialidades Medicas Santa Maria S.A.C
Piura, Peru
Clinica San Judas Tadeo
San Miguel, Peru, 32
Center for Diabetes Care
Iloilo, Philippines, 5000
Mary Mediatrix Medical Center
Lipa City, Batangas, Philippines, 4217
Philippine General Hospital
Manila, Philippines, 1000
University of Santo Tomas Hospital
Manila, Philippines, 1008
Manila Doctors Hospital
Manila, Philippines, 1011
Asian Hospital & Medical Center
Muntinlupa, Philippines, 1781
St. Luke's Medical Center
Quezon City, Philippines, 1102
Quirino Memorial Medical Center
Quezon City, Philippines, 1109
Cardinal Santos Medical Center
San Juan, Philippines, 1503
Surigao Health Specialists
Surigao, Philippines, 8400
Hospital Fernando Fonseca, EPE
Amadora, Portugal, 2700-276
CHLO, EPE - Hospital de Santa Cruz
Carnaxide, Portugal, 2799-523
CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
Coimbra, Portugal, 3000-075
Centro Hospitalar da Cova da Beira Hospital Pêro da Covilhã
Covilhã, Portugal, 6200-251
Hospital Distrital Figueira da Foz, EPE
Figueira da Foz, Portugal, 3094-001
Hospital da Luz
Lisboa, Portugal, 1500-650
Centro Hospitalar São João,EPE
Porto, Portugal, 4202-451
Centro Hospitalar de Entre o Douro e Vouga, E.P.E. - Hospital de São Sebastião
Santa Maria da Feira, Portugal, 4520-211
SC Diabol SRL, Brasov
Brasov, Romania, 500365
Nicodiab SRL, Bucharest
Bucharest, Romania, 010507
SC Medical Centre "Sanatatea Ta" SRL, Bucharest
Bucharest, Romania, 020614
Consultmed SRL, Iasi
Iasi, Romania, 700547
Emergency County Clinical Hospital, Sibiu
Sibiu, Romania, 550245
Private Practice Dr. Remus Gagiu
Tirgoviste, Romania, 130083
Russian Federation
LLC Clinic of new technologies of medicine
Dzerzhinsky, Russian Federation, 140091
City Clinical Hospital No. 6 of MoH of Udmurt Republic
Izhevsk, Russian Federation, 436000
City Clinical Hospital No. 4, Moscow
Moscow, Russian Federation, 115093
City Clinical Hospital No. 13, Moscow
Moscow, Russian Federation, 115280
State Institution "Central Clinical Hospital of RAS", Moscow
Moscow, Russian Federation, 117333
City Clinical Hospital No. 61, Moscow
Moscow, Russian Federation, 119048
State Healthcare Institution, Regional hospital #2
Rostov-na-Donu, Russian Federation, 344029
Limited Liability Company "CENTER DIABET", Samara
Samara, Russian Federation, 443067
MMU City Outpatient Clinic no. 20, Saratov
Saratov, Russian Federation, 410018
Clinical Medical Center Zvezdara, Belgrade
Belgrade, Serbia, 11000
Clinical Centre Nis
Nis, Serbia, 18000
General Hospital Pancevo
Pancevo, Serbia, 26000
General Hospital Subotica, Internal Medicine
Subotica, Serbia, 24000
Clinical Hospital Center Zemun
Zemun, Serbia, 11080
DIASTYLE s.r.o., Diabetology Outpatient Department
Banska Bystrica, Slovakia, 974 01
ENDIAMED s.r.o., Dolny Kubin
Dolny Kubin, Slovakia, 026 01
CELL B s.r.o.
Levice, Slovakia, 934 01
Levice, Slovakia, 934 01
Funkystuff s.r.o., Nove Zamky
Nove Zamky, Slovakia, 940 01
Diabetologicka ambulancia MUDr. Lucia Gajdosikova s.r.o.
Povazska Bystrica, Slovakia, 017 01
MEDIVASA s.r.o., Outpatient Clinic, Zilina
Zilina, Slovakia, 010 01
South Africa
Dr. P. Patel
Cape Town, South Africa, 7764
Dr. E. L. Janari
Cape Town, South Africa, 7965
Dr. Vawda
Durban, South Africa, 4091
Parklands Medical Centre
Durban, South Africa, 4091
Dr. Jurgens
Krugersdorp, South Africa, 1739
Dr. H. Makan
Lenasia, South Africa, 1827
Dr. D. R. Lakha, Johannesburg
Lenasia, South Africa, 2033
Greenacres Hospital
Port Elizabeth, South Africa, 6045
Dr. M. Seeber
Pretoria, South Africa, 0083
Vergelegen Medi-Clinic
Somerset West, South Africa, 7130
C.A.P. Sardenya
Barcelona, Spain, 08025
CAP Les Corts
Barcelona, Spain, 08028
CAP Casanova
Barcelona, Spain, 08036
CAP Burjassot 1
Burjassot, Spain, 46100
C.S. Natahoyo
Gijon, Spain, 33212
Hospital Universitari de Girona Doctor Josep Trueta
Girona, Spain, 17007
CAP Florida
L'Hospitalet de Llobregat, Spain, 08905
Hospital de Bellvitge
L'Hospitalet de Llobregat, Spain, 08907
CAP La Roca
La Roca Del Vallés (Barcelona), Spain, 08430
Hospital General Universitario Gregorio Marañón
Madrid, Spain, 28007
C.S. El Cristo
Oviedo, Spain, 33006
C.S. Colloto
Oviedo, Spain, 33010
C.S. Vallobin-La Florida
Oviedo, Spain, 33012
ABS Pineda de Mar
Pineda de Mar, Spain, 08397
Hospital de l'Esperit Sant
Santa Coloma De Gramanet, Spain, 08923
CAP Tàrrega
Tàrrega, Spain, 25300
CS Ingeniero Joaquin Benlloch
Valencia, Spain, 46006
Hospital Clínico de Valencia
Valencia, Spain, 46010
CTC Sahlgrenska Universitetssjukhuset
Göteborg, Sweden, 413 45
Sjukhuset, Härnösand
Härnösand, Sweden, 87182
Avonova Hälsa AB
Järfälla, Sweden, 177 30
Skånes universitetssjukhus, Malmö
Malmö, Sweden, 20502
Dalecarlia Clinical Research Center
Rättvik, Sweden, 795 30
Södra Dalarnas vårdcentral, Hedemora
Rättvik, Sweden, 79530
Näsets Läkargrupp
Skanör, Sweden, 239 33
Vårdcentralen Silentzvägen
Uddevalla, Sweden, 451 50
S3 Clinical Research Centers
Vällingby, Sweden, 162 68
Allgemeine Medizin
Basel, Switzerland, 4057
FMH endocrinologia diabetologia
Bellinzona, Switzerland, 6500
Inselspital Bern
Bern, Switzerland, 3010
Dr. Pietro Gerber
Lugano, Switzerland, 6900
Chang-Hua Christian Hospital
Changhua, Taiwan, 500
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan, 807
E-Da Hospital
Kaohsiung, Taiwan, 824
Far Eastern Memorial Hospital
New Taipei City, Taiwan, 220
Taichung Veterans General Hospital
Taichung,, Taiwan, 40705
China Medical University Hospital
Taichung, Taiwan, 40447
Tainan, Taiwan, 704
National Taiwan University Hospital
Taipei, Taiwan, 100
Shih-Kong Wu Ho-Shu Memorial Hospital
Taipei, Taiwan, 111
Taipe Veterans General Hospital
Taipei, Taiwan, 11217
Cheng Hsin General Hospital
Taipei, Taiwan, 112
Tri-Service General Hospital
Taipei, Taiwan, 114
Cardinal Tien Hospital
Taipei, Taiwan, 23137
Taipei Medical University-Shuang Ho Hospital
Taipei, Taiwan, 235
Mackay Memorial Hospital
Taipei, Taiwan, 25160
HOP Fattouma Bourguiba, Mint, Monastir
Monastir, Tunisia, 5000
HOP Hédi Chaker, Endo, Sfax
Sfax, Tunisia, 3029
HOP Farhat Hached, Mint, Sousse
Sousse, Tunisia, 4000
HOP Habib Thameur, Mint, Tunis
Tunis, Tunisia, 1008
Donetsk Regional Clinical Hosp, Therapy Department
Donetsk, Ukraine, 83003
Ivano-Frankivsk City Central Clinical Hospital
Ivano-Frankivsk, Ukraine, 76000
City Clinical Hospital No. 17, Kharkov
Kharkiv, Ukraine, 61037
City Clinical Hospital No. 27, Kharkiv
Kharkov, Ukraine, 61002
Clinic for Cardiology "Sertse i sudyny", Kiev
Kiev, Ukraine, 01032
City Clinical Hospital No. 1, Kiev
Kiev, Ukraine, 02091
Poliklinika #2, Kyiv
Kyiv, Ukraine, 02002
City Hospital No. 5, Lvov
Lvov, Ukraine, 73013
Odeska zaliznichna likarnya, Odessa
Odesa, Ukraine, 65039
Vinnitsia Regional Endocrinology Dispensary
Vinnitsa, Ukraine, 21010
United Kingdom
Crouch Oak Family Practice
Addlestone, United Kingdom, KT15 2BH
Ash Vale Health Centre, Aldershot
Ash Vale, Aldershot, United Kingdom, GU12 5BA
Birmingham Heartlands Hospital
Birmingham, United Kingdom, B9 5SS
Hathaway Medical Centre
Chippenham, United Kingdom, SN14 6GT
University Hospital of North Durham
Durham, United Kingdom, DH1 5TW
St Mary's Surgery
Ely, United Kingdom, CB7 4HF
Gloucestershire Royal Hospital
Gloucester, United Kingdom, GL1 3NN
James Paget University Hospital
Great Yarmouth, United Kingdom, NR31 6LA
Morriston Hospital
Swansea, United Kingdom, SA6 6NL
Royal Cornwall Hospital
Truro, United Kingdom, TR1 3LJ
Sponsors and Collaborators
Boehringer Ingelheim
Eli Lilly and Company
Study Chair: Boehringer Ingelheim Boehringer Ingelheim

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Boehringer Ingelheim Identifier: NCT01243424     History of Changes
Other Study ID Numbers: 1218.74
2009-013157-15 ( EudraCT Number )
First Posted: November 18, 2010    Key Record Dates
Last Update Posted: September 3, 2018
Last Verified: August 2018

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Anti-Arrhythmia Agents
Hypoglycemic Agents
Physiological Effects of Drugs
Immunosuppressive Agents
Immunologic Factors
Hormones, Hormone Substitutes, and Hormone Antagonists
Dipeptidyl-Peptidase IV Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action