Trial record 1 of 1 for:    E2408
Previous Study | Return to List | Next Study

Bendamustine Hydrochloride and Rituximab With or Without Bortezomib Followed by Rituximab With or Without Lenalidomide in Treating Patients With High-Risk Stage II, Stage III, or Stage IV Follicular Lymphoma

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2014 by Eastern Cooperative Oncology Group
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Eastern Cooperative Oncology Group
ClinicalTrials.gov Identifier:
NCT01216683
First received: October 6, 2010
Last updated: March 13, 2015
Last verified: June 2014
  Purpose

RATIONALE: Drugs used in chemotherapy, such as bendamustine hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing. It is not yet known whether giving bendamustine hydrochloride and rituximab together alone is more effective than giving bendamustine hydrochloride and rituximab together with bortezomib or lenalidomide in treating follicular lymphoma.

PURPOSE: This randomized phase II trial is studying giving bendamustine hydrochloride and rituximab together with or without bortezomib followed by rituximab with or without lenalidomide to see how well they work in treating patients with high-risk stage II, stage III, or stage IV follicular lymphoma.


Condition Intervention Phase
Lymphoma
Biological: rituximab
Drug: bendamustine hydrochloride
Drug: bortezomib
Drug: lenalidomide
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A 3-Arm Randomized Phase II Trial of Bendamustine-Rituximab (BR) Followed by Rituximab vs Bortezomib-BR (BVR) Followed by Rituximab vs BR Followed by Lenalidomide/Rituximab in High Risk Follicular Lymphoma

Resource links provided by NLM:


Further study details as provided by Eastern Cooperative Oncology Group:

Primary Outcome Measures:
  • Complete remission (CR) rate after induction therapy [ Designated as safety issue: No ]
  • 1-year post-induction disease-free survival rate [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Progression-free survival at 3 years [ Designated as safety issue: No ]
  • Overall survival at 5 years [ Designated as safety issue: No ]
  • Effect of continuation therapy in converting partial response or stable disease from induction into CR [ Designated as safety issue: No ]
  • Association of the original FLIPI-1 score with the recently reported FLIPI-2 score [ Designated as safety issue: No ]
  • Relationship between FLIPI-2 score and outcome [ Designated as safety issue: No ]
  • Overall health-related quality of life and disease-related symptoms as assessed by the FACT-Lymphoma subscale (FACTLym) [ Designated as safety issue: No ]
  • Treatment-related symptoms as assessed by the 13-item FACT-Fatigue scale and the 11-item FACT/GOG-Neurotoxicity scale [ Designated as safety issue: No ]
  • Disease-related symptoms and distress as assessed by the patient self-report assessment [ Designated as safety issue: No ]
  • Number of co-morbidities as assessed by the Cumulative Illness Rating Scale (CIRS) at 2 years [ Designated as safety issue: No ]
  • Relationship between CIRS score and outcome [ Designated as safety issue: No ]

Estimated Enrollment: 250
Study Start Date: December 2010
Estimated Primary Completion Date: August 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I
Patients receive rituximab IV on day 1 and bendamustine hydrochloride IV over 1 hour on days 1 and 2. Treatment repeats every 28 days for 6 courses in the absence of disease progression or unacceptable toxicity. Beginning 4 weeks after the completion of induction therapy, patients receive rituximab IV on day 1. Treatment repeats every 8 weeks for 2 years in the absence of disease progression or unacceptable toxicity.
Biological: rituximab
Given IV
Drug: bendamustine hydrochloride
Given IV
Experimental: Arm II
Patients receive rituximab IV on day 1, bortezomib IV on days 1, 4, 8, and 11, and bendamustine hydrochloride IV over 1 hour on days 1 and 4. Treatment repeats every 28 days for 6 courses in the absence of disease progression or unacceptable toxicity. Beginning 4 weeks after the completion of induction therapy, patients receive rituximab as in arm I.
Biological: rituximab
Given IV
Drug: bendamustine hydrochloride
Given IV
Drug: bortezomib
Given IV
Experimental: Arm III
Patients receive rituximab IV on day 1 and bendamustine hydrochloride IV over 1 hour on days 1 and 2. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity. Immediately after completing induction therapy, patients receive oral lenalidomide on days 1-21. Treatment repeats every 28 days for 13 courses in the absence of disease progression or unacceptable toxicity. Beginning 4 weeks after the completion of induction therapy, patients receive rituximab IV on day 1. Treatment repeats every 8 weeks for 2 years in the absence of disease progression or unacceptable toxicity.
Biological: rituximab
Given IV
Drug: bendamustine hydrochloride
Given IV
Drug: lenalidomide
Given orally

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed (biopsy-proven) diagnosis of follicular B-cell non-Hodgkin lymphoma with no evidence of transformation to large cell histology

    • Patients having both diffuse and follicular architectural elements are eligible if the histology is predominantly follicular (i.e., ≥ 50% of the cross-sectional area) and there is no evidence of transformation to a large cell histology
    • Diagnostic confirmation (i.e., core needle or excisional lymph node biopsy) required if the interval since tissue diagnosis of low-grade malignant lymphoma is > 24 months

      • Bone marrow biopsy alone not acceptable
  • Stage II, III, or IV AND grade 1, 2, or 3a disease
  • Must meet criteria for High Tumor Burden (higher risk) as defined by either the Groupe D'Etude des Lymphomes Follicularies (GELF) criteria OR the follicular lymphoma international prognostic index (FLIPI) as defined below:

    • Patient must meet ≥ 1 of the following GELF criteria:

      • Nodal or extranodal mass ≥ 7 cm
      • At least 3 nodal masses > 3.0 cm in diameter
      • Systemic symptoms due to lymphoma or B symptoms
      • Splenomegaly with spleen > 16 cm by CT scan
      • Evidence of compression syndrome (e.g., ureteral, orbital, gastrointestinal) or pleural or peritoneal serous effusion due to lymphoma (irrespective of cell content)
      • Leukemic presentation (≥ 5.0 x 10^9/L malignant circulating follicular cells)
      • Cytopenias (polymorphonuclear leukocytes < 1.0 X 10^9/L, hemoglobin < 10 g/dL, and/or platelets < 100 x 10^9/L)
    • Patient must have a FLIPI-1 score of 3, 4, or 5 (1 point per criterion below):

      • Age ≥ 60 years
      • Stage III-IV disease
      • Hemoglobin level < 12 g/dL
      • > 4 nodal areas
      • Serum LDH level above normal
  • At least 1 objective measurable disease parameter

    • Baseline measurements and evaluations (PET and CT) obtained within 6 weeks of randomization
    • Measurable disease in the liver is required if the liver is the only site of lymphoma

PATIENT CHARACTERISTICS:

  • See Disease Characteristics
  • ECOG performance status 0-2
  • ANC ≥ 1,500/mm³ (includes neutrophils and bands)
  • Platelet count ≥ 100,000/mm³
  • Creatinine ≤ 2.0 mg/dL
  • AST and ALT ≤ 5 x upper limit of normal (ULN)
  • Alkaline phosphatase ≤ 5 x ULN
  • Total bilirubin ≤ 1.5 x ULN (patients with known Gilbert disease should contact the study PI)
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use 2 effective methods (1 highly effective and 1 additional effective method) of contraception ≥ 28 days before, during, and for ≥ 28 days after completing study treatment
  • HIV-positive patients must meet all of the following criteria:

    • HIV is sensitive to antiretroviral therapy
    • Must be willing to take effective antiretroviral therapy if indicated
    • No history of CD4 < 300 cells/mm³ prior to or at the time of lymphoma diagnosis
    • No history of AIDS-defining conditions
    • If on antiretroviral therapy, must not be taking zidovudine or stavudine
    • Must be willing to take prophylaxis for Pneumocystis jiroveci pneumonia (PCP) during therapy and ≥ 2 months following completion of study therapy or until the CD4 cells recover to over 250 cells/mm³
  • No recent history of malignancy except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for ≥ 2 years
  • No active, uncontrolled infections (afebrile for > 48 hours off antibiotics)
  • No ≥ grade 2 neuropathy
  • No myocardial infarction within the past 6 months
  • No NYHA class III-IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities
  • No serious medical or psychiatric illness likely to interfere with participation in this clinical study
  • No known hypersensitivity to boron or mannitol
  • No chronic carriers of hepatitis B virus (HBV) with positive hepatitis surface antigen (HBsAg +)

    • Patients with a prior history of HBV infection, but immune, with only IgG hepatitis core antibody positive (HBcAb+), must receive antiviral prophylaxis (e.g., lamivudine 100 mg po daily) for ≥ 1 week prior to course 1 and throughout induction and continuation therapy and for ≥ 12 months after the last rituximab dose
  • Must register into the mandatory RevAssist® program and be willing and able to comply with the requirements of RevAssist® (for patients randomized to arm III)

PRIOR CONCURRENT THERAPY:

  • No prior chemotherapy, radiotherapy, or immunotherapy for lymphoma

    • Prednisone or other corticosteroids used for non-lymphomatous conditions will not be considered as prior chemotherapy
    • A prior/recent short course (< 2 weeks) of steroids for symptom relief of lymphoma-related symptoms is allowed
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01216683

  Hide Study Locations
Locations
United States, California
Marin Cancer Care Inc Recruiting
Greenbrae, California, United States, 94904
Contact: Peter D. Eisenberg    415-925-5000    info@marinspecialtycare.com   
Principal Investigator: Peter D. Eisenberg         
Salinas Valley Memorial Recruiting
Salinas, California, United States, 93901
Contact: Geetha N. Varma    831-759-1838    tnielsen2@svmh.com   
Principal Investigator: Geetha N. Varma         
Stanford University Hospitals and Clinics Recruiting
Stanford, California, United States, 94305
Contact: Ranjana H. Advani    650-498-7061    clinicaltrials@med.stanford.edu   
Principal Investigator: Ranjana H. Advani         
United States, Colorado
The Medical Center of Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Boulder Recruiting
Boulder, Colorado, United States, 80304
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Cancer Research Program CCOP Recruiting
Denver, Colorado, United States, 80224-2522
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Saint Joseph Hospital Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Presbyterian - Saint Lukes Medical Center - Health One Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Midtown Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Rose Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rose Medical Center Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Blood Cancer Institute Recruiting
Denver, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Comprehensive Cancer Care and Research Institute of Colorado LLC Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Poudre Valley Hospital Recruiting
Fort Collins, Colorado, United States, 80524
Contact: Regina J. Brown    970-297-6150      
Principal Investigator: Regina J. Brown         
Mountain Blue Cancer Care Center Recruiting
Golden, Colorado, United States, 80401
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Greenwood Village Recruiting
Greenwood Village, Colorado, United States, 80111
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Lakewood Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Anthony Hospital Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Sky Ridge Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Sky Ridge Medical Center Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Parker Adventist Hospital Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Parker Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Mary Corwin Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
North Suburban Medical Center Terminated
Thornton, Colorado, United States, 80229
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
United States, Delaware
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Gregory A. Masters    302-733-6227      
Principal Investigator: Gregory A. Masters         
United States, Georgia
Emory University/Winship Cancer Institute Recruiting
Atlanta, Georgia, United States, 30322
Contact: Christopher R. Flowers    404-778-1868      
Principal Investigator: Christopher R. Flowers         
Georgia Regents University Medical Center Recruiting
Augusta, Georgia, United States, 30912
Contact: Sharad A. Ghamande    706-721-1663    cancer@georgiahealth.edu   
Principal Investigator: Sharad A. Ghamande         
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
United States, Illinois
Rush - Copley Medical Center Recruiting
Aurora, Illinois, United States, 60504
Contact: Ronnie F. Luyun    800-446-5532      
Principal Investigator: Ronnie F. Luyun         
Illinois CancerCare-Bloomington Recruiting
Bloomington, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Saint Joseph Medical Center Recruiting
Bloomington, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Graham Hospital Association Terminated
Canton, Illinois, United States, 61520
Illinois CancerCare-Canton Recruiting
Canton, Illinois, United States, 61520
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Carthage Recruiting
Carthage, Illinois, United States, 62321
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Memorial Hospital Terminated
Carthage, Illinois, United States, 62321
Centralia Oncology Clinic Active, not recruiting
Centralia, Illinois, United States, 62801
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Jane N. Winter    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Jane N. Winter         
Rush University Medical Center Terminated
Chicago, Illinois, United States, 60612
Carle on Vermilion Recruiting
Danville, Illinois, United States, 61832
Contact: Ronnie F. Luyun    800-446-5532      
Principal Investigator: Ronnie F. Luyun         
Cancer Care Center of Decatur Active, not recruiting
Decatur, Illinois, United States, 62526
Decatur Memorial Hospital Active, not recruiting
Decatur, Illinois, United States, 62526
Carle Physician Group-Effingham Recruiting
Effingham, Illinois, United States, 62401
Contact: Ronnie F. Luyun    800-446-5532      
Principal Investigator: Ronnie F. Luyun         
Crossroads Cancer Center Active, not recruiting
Effingham, Illinois, United States, 62401
Eureka Hospital Active, not recruiting
Eureka, Illinois, United States, 61530
Illinois CancerCare-Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare Galesburg Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Mason District Hospital Terminated
Havana, Illinois, United States, 62644
Hinsdale Hematology Oncology Associates Incorporated Recruiting
Hinsdale, Illinois, United States, 60521
Contact: Elyse C. Schneiderman    630-654-1790    info@hhoaltd.com   
Principal Investigator: Elyse C. Schneiderman         
Illinois CancerCare-Kewanee Clinic Recruiting
Kewanee, Illinois, United States, 61443
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
North Shore Hematology Oncology Recruiting
Libertyville, Illinois, United States, 60048
Contact: Jane N. Winter    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Jane N. Winter         
Illinois CancerCare-Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Mcdonough District Hospital Terminated
Macomb, Illinois, United States, 61455
Carle Physician Group-Mattoon/Charleston Recruiting
Mattoon, Illinois, United States, 61938
Contact: Ronnie F. Luyun    800-446-5532      
Principal Investigator: Ronnie F. Luyun         
Illinois CancerCare-Monmouth Terminated
Monmouth, Illinois, United States, 61462
Illinois Cancer Specialists-Niles Recruiting
Niles, Illinois, United States, 60714
Contact: Jane N. Winter    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Jane N. Winter         
Bromenn Regional Medical Center Terminated
Normal, Illinois, United States, 61761
Community Cancer Center Foundation Terminated
Normal, Illinois, United States, 61761
Ottawa Regional Hospital and Healthcare Center Active, not recruiting
Ottawa, Illinois, United States, 61350
Illinois CancerCare-Ottawa Clinic Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Pekin Recruiting
Pekin, Illinois, United States, 61554
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Pekin Cancer Treatment Center Recruiting
Pekin, Illinois, United States, 61554
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois Oncology Research Association CCOP Terminated
Peoria, Illinois, United States, 61615
Methodist Medical Center of Illinois Recruiting
Peoria, Illinois, United States, 61603
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Proctor Hospital Terminated
Peoria, Illinois, United States, 61614
Illinois CancerCare-Peru Recruiting
Peru, Illinois, United States, 61354
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois Valley Hospital Terminated
Peru, Illinois, United States, 61354
Illinois CancerCare-Princeton Recruiting
Princeton, Illinois, United States, 61356
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Perry Memorial Hospital Terminated
Princeton, Illinois, United States, 61356
Swedish American Hospital Withdrawn
Rockford, Illinois, United States, 61104
SwedishAmerican Regional Cancer Center/ACT Recruiting
Rockford, Illinois, United States, 61107
Contact: Harvey E. Einhorn    779-696-9400    cancercare@swedishamerican.org   
Principal Investigator: Harvey E. Einhorn         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Ronnie F. Luyun    800-446-5532      
Principal Investigator: Ronnie F. Luyun         
The Carle Foundation Hospital Recruiting
Urbana, Illinois, United States, 61801
Contact: Ronnie F. Luyun    800-446-5532      
Principal Investigator: Ronnie F. Luyun         
United States, Indiana
Horizon Oncology Center Withdrawn
Lafayette, Indiana, United States, 47905
IU Health Arnett Cancer Care Active, not recruiting
Lafayette, Indiana, United States, 47904
Franciscan Saint Anthony Health-Michigan City Recruiting
Michigan City, Indiana, United States, 46360
Contact: Ronnie F. Luyun    800-446-5532      
Principal Investigator: Ronnie F. Luyun         
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Ottumwa Regional Health Center Active, not recruiting
Ottumwa, Iowa, United States, 52501
Mercy Medical Center-Sioux City Terminated
Sioux City, Iowa, United States, 51104
Saint Luke's Regional Medical Center Terminated
Sioux City, Iowa, United States, 51104
Siouxland Hematology Oncology Associates Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
United States, Kansas
Lawrence Memorial Hospital Recruiting
Lawrence, Kansas, United States, 66044
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Wesley Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
United States, Louisiana
Ochsner Health Center-Summa Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
Ochsner Medical Center Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
Ochsner Baptist Medical Center Recruiting
New Orleans, Louisiana, United States, 70115
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
United States, Maryland
Greater Baltimore Medical Center Recruiting
Baltimore, Maryland, United States, 21204
Contact: Marshall A. Levine    443-849-3706      
Principal Investigator: Marshall A. Levine         
United States, Massachusetts
Dana-Farber Harvard Cancer Center Recruiting
Boston, Massachusetts, United States, 02115
Contact: Jon E. Arnason       jarnason@bidmc.harvard.edu   
Principal Investigator: Jon E. Arnason         
Tufts Medical Center Recruiting
Boston, Massachusetts, United States, 02111
Contact: Andrew M. Evens    617-636-5000    ContactUsCancerCenter@TuftsMedicalCenter.org   
Principal Investigator: Andrew M. Evens         
University of Massachusetts Medical School Recruiting
Worcester, Massachusetts, United States, 01655
Contact: Alan G. Rosmarin    508-856-3216    cancer.research@umassmed.edu   
Principal Investigator: Alan G. Rosmarin         
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Green Bay Oncology - Escanaba Recruiting
Escanaba, Michigan, United States, 49431
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Green Bay Oncology - Iron Mountain Recruiting
Iron Mountain, Michigan, United States, 49801
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Allegiance Health Recruiting
Jackson, Michigan, United States, 49201
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Sunil Nagpal    269-373-7458      
Principal Investigator: Sunil Nagpal         
Bronson Methodist Hospital Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Sunil Nagpal    269-373-7458      
Principal Investigator: Sunil Nagpal         
Borgess Medical Center Recruiting
Kalamazoo, Michigan, United States, 49001
Contact: Sunil Nagpal    269-373-7458      
Principal Investigator: Sunil Nagpal         
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
United States, Minnesota
Sanford Clinic North-Bemidgi Recruiting
Bemidji, Minnesota, United States, 56601
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Essentia Health Saint Joseph's Medical Center Recruiting
Brainerd, Minnesota, United States, 56401
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Essentia Health Cancer Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Essentia Health Saint Mary's Medical Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Miller-Dwan Hospital Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Hutchinson Area Health Care Recruiting
Hutchinson, Minnesota, United States, 55350
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Thomas M. Habermann    507-538-7623      
Principal Investigator: Thomas M. Habermann         
Metro-Minnesota CCOP Terminated
Saint Louis Park, Minnesota, United States, 55416
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Lakeview Hospital Active, not recruiting
Stillwater, Minnesota, United States, 55082
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Minnesota Oncology and Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United States, Missouri
Saint Francis Medical Center Active, not recruiting
Cape Girardeau, Missouri, United States, 63703
United States, New Jersey
Cooper Hospital University Medical Center Withdrawn
Camden, New Jersey, United States, 08103
Veterans Adminstration New Jersey Health Care System Recruiting
East Orange, New Jersey, United States, 07018-1095
Contact: Basil S. Kasimis    800-475-2336    patricia.goyer@med.va.gov   
Principal Investigator: Basil S. Kasimis         
Hunterdon Medical Center Terminated
Flemington, New Jersey, United States, 08822
Cancer Institute of New Jersey At Hamilton Recruiting
Hamilton, New Jersey, United States, 08690
Contact: Kevin A. David    732-235-8675      
Principal Investigator: Kevin A. David         
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Withdrawn
Mount Holly, New Jersey, United States, 08060
Rutgers Cancer Institute of New Jersey Recruiting
New Brunswick, New Jersey, United States, 08903
Contact: Kevin A. David    732-235-8675      
Principal Investigator: Kevin A. David         
UMDNJ - New Jersey Medical School Active, not recruiting
Newark, New Jersey, United States, 07103
United States, New York
New York University Langone Medical Center Active, not recruiting
New York, New York, United States, 10016
United States, North Dakota
Essentia Health Cancer Center-South University Clinic Active, not recruiting
Fargo, North Dakota, United States, 58103
Roger Maris Cancer Center Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Sanford Clinic North-Fargo Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Sanford Medical Center-Fargo Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center Recruiting
Akron, Ohio, United States, 44304
Contact: Jennifer E. Payne    330-375-6101      
Principal Investigator: Jennifer E. Payne         
Toledo Clinic Cancer Centers-Bowling Green Terminated
Bowling Green, Ohio, United States, 43402
Mercy Medical Center Recruiting
Canton, Ohio, United States, 44708
Contact: Mitchell Haut    888-293-4673      
Principal Investigator: Mitchell Haut         
Aultman Health Foundation Withdrawn
Canton, Ohio, United States, 44710
Geaugra Hospital Recruiting
Chardon, Ohio, United States, 44024
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
MetroHealth Medical Center Recruiting
Cleveland, Ohio, United States, 44109
Contact: Bruce J. Averbook    216-778-8526    kbauchens@metrohealth.org   
Principal Investigator: Bruce J. Averbook         
Ireland Cancer Center Landerbrook Health Center Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
Lake University Ireland Cancer Center Recruiting
Mentor, Ohio, United States, 44060
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
Southwest General Health Center Ireland Cancer Center Recruiting
Middleburg Heights, Ohio, United States, 44130
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
UHHS-Chagrin Highlands Medical Center Recruiting
Orange Village, Ohio, United States, 44122
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
Toledo Clinic Cancer Centers-Oregon Terminated
Oregon, Ohio, United States, 43616
Ireland Cancer Center at Firelands Regional Medical Center Recruiting
Sandusky, Ohio, United States, 44870
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
Flower Hospital Terminated
Sylvania, Ohio, United States, 43560
Toledo Community Hospital Oncology Program CCOP Active, not recruiting
Toledo, Ohio, United States, 43617
Toledo Clinic Cancer Centers-Toledo Recruiting
Toledo, Ohio, United States, 43623
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
University Hospitals Sharon Health Center Recruiting
Wadsworth, Ohio, United States, 44281
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
UH-Seidman Cancer Center at Saint John Medical Center Recruiting
Westlake, Ohio, United States, 44145
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
UHHS-Westlake Medical Center Recruiting
Westlake, Ohio, United States, 44145
Contact: Paolo F. Caimi    800-641-2422      
Principal Investigator: Paolo F. Caimi         
United States, Pennsylvania
Abington Memorial Hospital Recruiting
Abington, Pennsylvania, United States, 19001
Contact: Willard G. Andrews    215-481-2402      
Principal Investigator: Willard G. Andrews         
Bryn Mawr Hospital Withdrawn
Bryn Mawr, Pennsylvania, United States, 19010
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Ephrata Cancer Center Withdrawn
Ephrata, Pennsylvania, United States, 17522
Geisinger Medical Center-Cancer Center Hazleton Recruiting
Hazleton, Pennsylvania, United States, 18201
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Penn State Milton S Hershey Medical Center Active, not recruiting
Hershey, Pennsylvania, United States, 17033-0850
Geisinger Medical Oncology at Evangelical Community Hospital Recruiting
Lewisburg, Pennsylvania, United States, 17837
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Lewistown Hospital Recruiting
Lewistown, Pennsylvania, United States, 17044
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Paoli Memorial Hospital Withdrawn
Paoli, Pennsylvania, United States, 19301
Pennsylvania Hospital Active, not recruiting
Philadelphia, Pennsylvania, United States, 19107
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Barbara Pro    215-955-6084      
Principal Investigator: Barbara Pro         
Aria Health-Torresdale Campus Terminated
Philadelphia, Pennsylvania, United States, 19114
Geisinger Medical Oncology-Pottsville Recruiting
Pottsville, Pennsylvania, United States, 17901
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Hematology and Oncology Associates of North East Pennsylvania Recruiting
Scranton, Pennsylvania, United States, 18508
Contact: Barbara Pro    215-955-6084      
Principal Investigator: Barbara Pro         
Mount Nittany Medical Center Active, not recruiting
State College, Pennsylvania, United States, 16803
Geisinger Medical Group Recruiting
State College, Pennsylvania, United States, 16801
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Terrence P. Cescon    610-988-9323      
Principal Investigator: Terrence P. Cescon         
Geisinger Wyoming Valley Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Lankenau Medical Center Withdrawn
Wynnewood, Pennsylvania, United States, 19096
United States, South Dakota
Sanford Cancer Center-Oncology Clinic Recruiting
Sioux Falls, South Dakota, United States, 57104
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Sanford USD Medical Center - Sioux Falls Recruiting
Sioux Falls, South Dakota, United States, 57117-5134
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
United States, Tennessee
Vanderbilt-Ingram Cancer Center Cool Springs Active, not recruiting
Franklin, Tennessee, United States, 37067
Vanderbilt-Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Nishitha Reddy    800-811-8480      
Principal Investigator: Nishitha Reddy         
United States, Texas
Parkland Memorial Hospital Active, not recruiting
Dallas, Texas, United States, 75235
University of Texas Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75390
Contact: Harris V. Naina    214-648-7097      
Principal Investigator: Harris V. Naina         
United States, West Virginia
West Virginia University Charleston Recruiting
Charleston, West Virginia, United States, 25304
Contact: Steven J. Jubelirer    304-344-3457      
Principal Investigator: Steven J. Jubelirer         
West Virginia University Healthcare Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Abraham S. Kanate    304-293-2745    sfilburn@hsc.wvu.edu   
Principal Investigator: Abraham S. Kanate         
United States, Wisconsin
Langlade Hospital and Cancer Center Recruiting
Antigo, Wisconsin, United States, 54409
Contact: Hamied R. Rezazadeh    877-405-6866      
Principal Investigator: Hamied R. Rezazadeh         
Fox Valley Hematology and Oncology Recruiting
Appleton, Wisconsin, United States, 54911
Contact: William A. Conkright    920-749-1171      
Principal Investigator: William A. Conkright         
Marshfield Clinic-Chippewa Center Active, not recruiting
Chippewa Falls, Wisconsin, United States, 54729
Marshfield Clinic Cancer Center at Sacred Heart Active, not recruiting
Eau Claire, Wisconsin, United States, 54701
Aurora BayCare Medical Center Active, not recruiting
Green Bay, Wisconsin, United States, 54311-6519
Bellin Memorial Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54301
Green Bay Oncology at Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301-3526
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Green Bay Oncology Limited at Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
UW Cancer Center Johnson Creek Active, not recruiting
Johnson Creek, Wisconsin, United States, 53038
Gundersen Lutheran Medical Center Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Kurt Oettel    608-775-2385    cancerctr@gundluth.org   
Principal Investigator: Kurt Oettel         
Dean Hematology and Oncology Clinic Active, not recruiting
Madison, Wisconsin, United States, 53717
University of Wisconsin Hospital and Clinics Recruiting
Madison, Wisconsin, United States, 53792
Contact: Brad S. Kahl    877-405-6866      
Principal Investigator: Brad S. Kahl         
Vince Lombardi Cancer Clinic-Marinette Active, not recruiting
Marinette, Wisconsin, United States, 54143
Marshfield Clinic Active, not recruiting
Marshfield, Wisconsin, United States, 54449
Saint Joseph's Hospital Active, not recruiting
Marshfield, Wisconsin, United States, 54449
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Timothy S. Fenske    414-805-4380      
Principal Investigator: Timothy S. Fenske         
Marshfield Clinic-Minocqua Center Active, not recruiting
Minocqua, Wisconsin, United States, 54548
Oconomowoc Memorial Hospital-ProHealth Care Inc Recruiting
Oconomowoc, Wisconsin, United States, 53066-3896
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Green Bay Oncology - Oconto Falls Recruiting
Oconto Falls, Wisconsin, United States, 54154
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Vince Lombardi Cancer Clinic - Oshkosh Active, not recruiting
Oshkosh, Wisconsin, United States, 54904
Marshfield Clinic at James Beck Cancer Center Active, not recruiting
Rhinelander, Wisconsin, United States, 54501
Saint Mary's Hospital Active, not recruiting
Rhinelander, Wisconsin, United States, 54501
Marshfield Clinic-Rice Lake Center Active, not recruiting
Rice Lake, Wisconsin, United States, 54868
Saint Nicholas Hospital Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Vince Lombardi Cancer Clinic-Sheboygan Active, not recruiting
Sheboygan, Wisconsin, United States, 53081
Saint Michael's Hospital Active, not recruiting
Stevens Point, Wisconsin, United States, 54481
Marshfield Clinic Cancer Care at Saint Michael's Hospital Active, not recruiting
Stevens Point, Wisconsin, United States, 54481
Green Bay Oncology - Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235
Contact: Brian L. Burnette    800-432-6049      
Principal Investigator: Brian L. Burnette         
Aurora Medical Center in Summit Active, not recruiting
Summit, Wisconsin, United States, 53066
Vince Lombardi Cancer Clinic Active, not recruiting
Two Rivers, Wisconsin, United States, 54241
Waukesha Memorial Hospital - ProHealth Care Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Aspirus Regional Cancer Center Recruiting
Wausau, Wisconsin, United States, 54401
Contact: Hamied R. Rezazadeh    877-405-6866      
Principal Investigator: Hamied R. Rezazadeh         
Aurora Cancer Care-Milwaukee West Active, not recruiting
Wauwatosa, Wisconsin, United States, 53226
Diagnostic and Treatment Center Active, not recruiting
Weston, Wisconsin, United States, 54476
Marshfield Clinic - Weston Center Active, not recruiting
Weston, Wisconsin, United States, 54476
Marshfield Clinic - Wisconsin Rapids Center Active, not recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
Riverview Hospital Recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
Contact: Ronnie J. Kirschling    877-405-6866      
Principal Investigator: Ronnie J. Kirschling         
Sponsors and Collaborators
Eastern Cooperative Oncology Group
Investigators
Principal Investigator: Andrew M. Evens, DO, MS Robert H. Lurie Cancer Center
  More Information

Additional Information:
No publications provided

Responsible Party: Eastern Cooperative Oncology Group
ClinicalTrials.gov Identifier: NCT01216683     History of Changes
Other Study ID Numbers: E2408, E2408, NCI-2011-02644, CDR0000683312
Study First Received: October 6, 2010
Last Updated: March 13, 2015
Health Authority: United States: Food and Drug Administration

Keywords provided by Eastern Cooperative Oncology Group:
contiguous stage II grade 1 follicular lymphoma
contiguous stage II grade 2 follicular lymphoma
contiguous stage II grade 3 follicular lymphoma
noncontiguous stage II grade 1 follicular lymphoma
noncontiguous stage II grade 2 follicular lymphoma
noncontiguous stage II grade 3 follicular lymphoma
stage III grade 1 follicular lymphoma
stage III grade 2 follicular lymphoma
stage III grade 3 follicular lymphoma
stage IV grade 1 follicular lymphoma
stage IV grade 2 follicular lymphoma
stage IV grade 3 follicular lymphoma

Additional relevant MeSH terms:
Lymphoma
Lymphoma, Follicular
Immune System Diseases
Immunoproliferative Disorders
Lymphatic Diseases
Lymphoma, Non-Hodgkin
Lymphoproliferative Disorders
Neoplasms
Neoplasms by Histologic Type
Bendamustine
Bortezomib
Lenalidomide
Nitrogen Mustard Compounds
Rituximab
Alkylating Agents
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Antineoplastic Agents
Antineoplastic Agents, Alkylating
Antirheumatic Agents
Growth Inhibitors
Growth Substances
Immunologic Factors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses

ClinicalTrials.gov processed this record on April 23, 2015