Revitalization of Teeth With Necrotic Pulps and Open Apexes Using Platelet-Rich Plasma
|ClinicalTrials.gov Identifier: NCT01212939|
Recruitment Status : Terminated (No advantage seen during continued animal studies. Difficult recruitment.)
First Posted : October 1, 2010
Last Update Posted : April 4, 2014
|Condition or disease|
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Procedures Participants in this study must be in overall good health and not allergic to the materials used during this study treatment. If you agree to participate in this study, you will receive a screening visit to determine whether you will qualify for the study. At that time, your medical history will be reviewed, your blood pressure and pulse will be taken and you will be asked to fill out detailed medical and dental histories. In addition, you will receive an examination of your teeth and gums.
In the first appointment, after anesthetizing you with a local anesthetic similar to Novocain and application of a rubber dam to isolate your tooth, an opening will be made into the root canal(s). The canal(s) will be cleaned and medicated with antibiotics to get rid of the infection and sealed with a temporary filling material. Except for the use of antibiotics the rest of the procedures done in this appointment are similar to what the investigators do for the patients for need root canal treatment.
In the second appointment, after providing anesthesia with Novocain and application of rubber dam again, the temporary filling will be removed and the antibiotic will be removed using sterile water. The canal will be then dried. During this appointment, 20 ml of whole blood will be taken from your arm vein and will be used to prepare concentrated cells for injection into the prepared canal and sealed again with a temporary filling material. This part is different than what the investigators normally do for patients who need root canal treatment. For those patients the investigators fill the canals and seal the opening into the root canals with a permanent filling material.
You will return three to seven days later to the endodontic clinic and at that time, after rubber dam application, the temporary filling material will be removed and the tooth will be double sealed with permanent filling materials. This is an extra step that the investigators normally do not take for patients who need root canal treatment. A dental assistant or a dentist will call you to make an appointment at 3, 6, 12, 18, and 24 months following completion of your root canal treatment to check the vitality of the tooth using an ice stick and closure of the root end. Checking the process of healing in your tooth is similar to what the investigators routinely do for our patients who require root canal treatment.
Risks The study will require drawing blood from your arm. Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others. Other risks associated with having blood drawn are slight but may include bleeding, fainting or feeling light-headed, hematoma (blood accumulating under the skin), and infection (a slight risk any time the skin is broken). In rare instances, it may cause severe pain of infection. Depending upon the complications, your dentist may decide to remove the PRP completely out of the root canal and the use other procedures to treat your tooth. Should root canal failure occur, further dental treatment will be rendered at no charge to you.
Benefits Whether or not you will benefit from this study is not yet known. However, there is a possibility of saving the tooth with this procedure. Your participation will help dentists learn about the importance of regeneration of nerves in teeth with infection and open root ends, and may help save your tooth.
Participants' Rights Your participation in this study is voluntary. Your decision whether or not to participate or terminate at any time will not affect your present or future treatment here at the Dental School. You may withdraw from the study at any time that you want to.
Alternative Treatments You can choose not to participate in this study and have your tooth treated with the standard root canal procedures or have it extracted. Refusal to participate in this study will involve no penalties or loss of usual benefits to which you are entitled.
Confidentiality The medical information collected in this study will be available to the investigators, the U.S. Food and Drug Administration, and the Institutional Review Board of Loma Linda University. The results may be published but your name will not be used in publications. However, submission of the information will be accomplished with strict adherence to the professional standards of confidentiality. See attached PHI Authorization for more information about your privacy. Your name and address will be kept on record at the investigator's office in case you need to be contacted in the future about this study.
|Study Type :||Observational|
|Estimated Enrollment :||10 participants|
|Official Title:||Revitalization of Teeth With Necrotic Pulps and Open Apexes Using Platelet-Rich Plasma|
|Study Start Date :||October 2012|
|Primary Completion Date :||December 2013|
|Study Completion Date :||December 2013|
- stop the infection [ Time Frame: 6 weeks ]
- Revitalizing the nerve of the tooth [ Time Frame: Every 3-6 months for two years ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01212939
|United States, California|
|Loma Linda Dental School|
|Loma Linda, California, United States, 92350|
|Loma Linda University|
|Loma Linda, California, United States, 92354|
|Principal Investigator:||Mahmoud Torabinejad, DDS||Loma Linda University|