Impact of Physical Activity on Left Ventricular Mass and Lipid Metabolism
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|ClinicalTrials.gov Identifier: NCT01199211|
Recruitment Status : Terminated (IRB approval expired)
First Posted : September 10, 2010
Last Update Posted : July 31, 2020
|Condition or disease||Intervention/treatment|
|Left Ventricular Hypertrophy||Other: Exercise training, women, marathon|
Left ventricular hypertrophy, defined as an increase in the mass of the left ventricle may occur as a physiologic response to exercise (athletic remodeling aka "athletic heart"), but is most frequently encountered as a pathological manifestation of cardiovascular disease. The early determinants of athletic remodeling in the general population are largely unknown. In order to longitudinally explore the early determinants of athletic remodeling, we will recruit from the community, physically untrained women who have volunteered to run a marathon. We will prospectively assess left ventricular mass and function by echocardiogram during three consecutive stages/visits:
- Baseline: prior to starting intense physical training
- Trained: at the end of at least 12 week training period, prior to running the marathon.
- Post-marathon: 6 weeks after running the marathon.
In addition, exercise impacts lipid metabolism and short-term exercise is known to increase HDL levels in plasma. Human HDL is structurally heterogeneous, comprising at least sixteen discrete species. It has multiple functions, pertinent to cardiovascular medicine such as the ability to accept effluxed cholesterol from the artery wall, culminating in sterol uptake in the liver. This "reverse cholesterol transport pathway" is thought to prevent the accumulation of cholesterol in the artery wall. We will assess the clinical and genetic determinants of the HDL response to physical exercise.
|Study Type :||Observational|
|Actual Enrollment :||187 participants|
|Official Title:||Impact of Physical Activity on Left Ventricular Mass and Lipid Metabolism in Healthy Female Volunteers Training for a Marathon|
|Study Start Date :||February 2011|
|Actual Primary Completion Date :||October 2017|
|Actual Study Completion Date :||October 2017|
Exercise training, women, marathon.
Other: prospective study with no intervention
Other: Exercise training, women, marathon
Prospective study with no intervention in women who have volunteered to run a full marathon or a half-marathon. Each subject will serve as own control. Each subject will be studies at 3 stages: baseline, after at least 12 weeks of training for the marathon (we will not provide training), 6 weeks after running the marathon.
- Lipid Metabolism [ Time Frame: Baseline, In-Training, Post-training (at least 6 weeks after the race) ]
- Heart architecture and function [ Time Frame: Baseline, In-training, Post-training ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01199211
|United States, California|
|CTSI - University of California San Francisco|
|San Francisco, California, United States, 94143|
|Principal Investigator:||Eveline Stock, MD||University of California, San Francisco|
|Principal Investigator:||Nelson Schiller, MD||University of California, San Francisco|