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Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER®)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Novo Nordisk A/S
ClinicalTrials.gov Identifier:
NCT01179048
First received: August 6, 2010
Last updated: January 10, 2017
Last verified: January 2017
  Purpose
This trial is conducted in Africa, Asia, Europe, and North and South America. The aim of this trial is to determine the long term effect of liraglutide on cardiovascular events in subjects with type 2 diabetes.

Condition Intervention Phase
Diabetes
Diabetes Mellitus, Type 2
Drug: liraglutide
Drug: placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: A Long-term, Multi-centre, International, Randomised Double-blind, Placebo-controlled Trial to Determine Liraglutide Effects on Cardiovascular Events

Resource links provided by NLM:


Further study details as provided by Novo Nordisk A/S:

Primary Outcome Measures:
  • Time From Randomisation to First Occurrence of Cardiovascular Death, Non-fatal Myocardial Infarction, or Non-fatal Stroke (a Composite Cardiovascular Outcome) [ Time Frame: from randomisation (visit 3; month 0) to last contact (visit 16; up to month 60+30 days) ]
    Subjects experiencing a first event of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke (a composite cardiovascular outcome).


Secondary Outcome Measures:
  • Time From Rand. to First Occurrence of an Expanded Composite Cardiovascular Outcome Defined as Either Cardiovascular Death, Non-fatal Myocardial Infarction, Non-fatal Stroke, Revascularisation, Hospitalisation for Unstable Angina or for Heart Failure. [ Time Frame: from randomisation (visit 3; month 0) to last contact (visit 16; up to month 60+30 days) ]
    Subjects experiencing first occurrence of an expanded composite cardiovascular outcome defined as either cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularisation, hospitalisation for unstable angina or for heart failure.

  • Time From Randomisation to All Cause Death [ Time Frame: from randomisation (visit 3; month 0) to last contact (visit 16; up to month 60+30 days) ]
    Subjects with a death by any cause (all-cause death) between randomisation date and last follow-up date.

  • Time From Randomisation to Each Individual Component of the Expanded Composite Cardiovascular Outcome [ Time Frame: from randomisation (visit 3; month 0) to last contact (visit 16; up to month 60+30 days) ]
    Subjects experiencing each of the individual component of the expanded composite cardiovascular outcome (defined as either cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularisation, hospitalisation for unstable angina or heart failure)


Enrollment: 9340
Study Start Date: August 2010
Study Completion Date: December 2015
Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Liraglutide Drug: liraglutide
Maximum dose of 1.8 mg liraglutide, injected subcutaneously (under the skin) once daily. Administered in addition to the subject's standard treatment
Placebo Comparator: Placebo Drug: placebo
Maximum dose of 1.8 mg placebo, injected subcutaneously (under the skin) once daily. Administered in addition to the subject's standard treatment

  Eligibility

Ages Eligible for Study:   50 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Type 2 diabetes
  • Age min. 50 years at screening and concomitant cardiovascular, cerebrovascular or peripheral vascular disease or chronic renal failure or chronic heart failure OR age min. 60 years at screening and other specified risk factors of cardiovascular disease
  • HbA1c: 7.0% or above
  • Anti-diabetic drug naive or treated with one or more oral anti-diabetic drugs (OADs) or treated with human NPH insulin or long-acting insulin analogue or premixed insulin, alone or in combination with OAD(s)

Exclusion Criteria:

  • Type 1 diabetes
  • Use of a glucagon-like peptide-1 (GLP-1) receptor agonist (exenatide, liraglutide or other) or pramlintide or any dipeptidyl peptidase 4 (DPP-4) inhibitor within the 3 months prior to screening (trial start)
  • Use of insulin other than human NPH insulin or long-acting insulin analogue or premixed insulin within 3 months prior to screening. Short-term use of other insulin during this period in connection with intercurrent illness is allowed, at Investigator's discretion
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01179048

  Hide Study Locations
Locations
United States, Alabama
Novo Nordisk Investigational Site
Alabaster, Alabama, United States, 35007
Novo Nordisk Investigational Site
Birmingham, Alabama, United States, 35209
Novo Nordisk Investigational Site
Birmingham, Alabama, United States, 35294
Novo Nordisk Investigational Site
Huntsville, Alabama, United States, 35801
Novo Nordisk Investigational Site
Mobile, Alabama, United States, 36608
United States, Arizona
Novo Nordisk Investigational Site
Tempe, Arizona, United States, 85283
United States, Arkansas
Novo Nordisk Investigational Site
Little Rock, Arkansas, United States, 72205-5446
Novo Nordisk Investigational Site
Little Rock, Arkansas, United States, 72205
United States, California
Novo Nordisk Investigational Site
Anaheim, California, United States, 92801
Novo Nordisk Investigational Site
Cerritos, California, United States, 90703-2115
Novo Nordisk Investigational Site
Escondido, California, United States, 92025
Novo Nordisk Investigational Site
Fresno, California, United States, 93721-1443
Novo Nordisk Investigational Site
Los Angeles, California, United States, 90017-4006
Novo Nordisk Investigational Site
Los Banos, California, United States, 93635
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Mission Hills, California, United States, 91345
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Montclair, California, United States, 91763
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San Diego, California, United States, 92111
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Tustin, California, United States, 92780
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Walnut Creek, California, United States, 94598
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Watsonville, California, United States, 95076
United States, Colorado
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Aurora, Colorado, United States, 80045-7402
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Denver, Colorado, United States, 80220
United States, Delaware
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Newark, Delaware, United States, 19713
United States, Florida
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Bradenton, Florida, United States, 34201
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Clearwater, Florida, United States, 33756
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Deland, Florida, United States, 32724
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Fort Lauderdale, Florida, United States, 33316
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Kissimmee, Florida, United States, 34744
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Miami, Florida, United States, 33136
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Orlando, Florida, United States, 32804
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St. Petersburg, Florida, United States, 33711
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Tampa, Florida, United States, 34677
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West Palm Beach, Florida, United States, 33409
United States, Georgia
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Lawrenceville, Georgia, United States, 30046
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Roswell, Georgia, United States, 30076
United States, Illinois
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Chicago, Illinois, United States, 60612
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Chicago, Illinois, United States, 60616
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Chicago, Illinois, United States, 60654
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Crystal Lake, Illinois, United States, 60012
United States, Indiana
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Indianapolis, Indiana, United States, 46260-1992
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Michigan City, Indiana, United States, 46360
United States, Iowa
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Des Moines, Iowa, United States, 50314-2610
United States, Kentucky
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Lexington, Kentucky, United States, 40502
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Louisville, Kentucky, United States, 40202
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Louisville, Kentucky, United States, 40206
United States, Louisiana
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Metairie, Louisiana, United States, 70006-2930
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Monroe, Louisiana, United States, 71203
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Natchitoches, Louisiana, United States, 71457-5881
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New Orleans, Louisiana, United States, 70112
United States, Maryland
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Baltimore, Maryland, United States, 21204
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Baltimore, Maryland, United States, 21218-2829
United States, Michigan
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Bloomfield Hills, Michigan, United States, 48302
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Dearborn, Michigan, United States, 48124
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Interlochen, Michigan, United States, 49643
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Troy, Michigan, United States, 48085-5524
United States, Minnesota
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Minneapolis, Minnesota, United States, 55416
United States, Missouri
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Springfield, Missouri, United States, 65807
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St. Louis, Missouri, United States, 63108
United States, Montana
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Great Falls, Montana, United States, 59405
United States, Nebraska
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Omaha, Nebraska, United States, 68105
United States, New Hampshire
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Lebanon, New Hampshire, United States, 03756
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Nashua, New Hampshire, United States, 03063
United States, New Jersey
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Mine Hill, New Jersey, United States, 07803
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Neptune, New Jersey, United States, 07753-4859
United States, New York
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Albany, New York, United States, 12208
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Buffalo, New York, United States, 14221-7091
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New York, New York, United States, 10032
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New York, New York, United States, 10036
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New York, New York, United States, 10065
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Smithtown, New York, United States, 11787
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Syracuse, New York, United States, 13210
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Westfield, New York, United States, 14787
United States, North Carolina
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Asheville, North Carolina, United States, 28801
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Burlington, North Carolina, United States, 27215-8700
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Chapel Hill, North Carolina, United States, 27517
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Greensboro, North Carolina, United States, 27401
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Greenville, North Carolina, United States, 27834
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Monroe, North Carolina, United States, 28110
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Mooresville, North Carolina, United States, 28117
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Morehead City, North Carolina, United States, 28557
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Whiteville, North Carolina, United States, 28472
United States, Ohio
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Cadiz, Ohio, United States, 43907
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Cincinnati, Ohio, United States, 45219
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Cincinnati, Ohio, United States, 45220-2213
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Cleveland, Ohio, United States, 44106
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Marion, Ohio, United States, 43302
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Middleburg Heights, Ohio, United States, 44310
United States, Oklahoma
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Oklahoma City, Oklahoma, United States, 73103
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Oklahoma City, Oklahoma, United States, 73104
United States, Pennsylvania
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Altoona, Pennsylvania, United States, 16602
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Beaver, Pennsylvania, United States, 15009-1957
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Hatfield, Pennsylvania, United States, 19440
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Philadelphia, Pennsylvania, United States, 19104
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Philadelphia, Pennsylvania, United States, 19107
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Pittsburgh, Pennsylvania, United States, 15243
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Uniontown, Pennsylvania, United States, 15401
United States, South Carolina
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Charleston, South Carolina, United States, 29455
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Columbia, South Carolina, United States, 29203
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Greenville, South Carolina, United States, 29607
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Greer, South Carolina, United States, 29651
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Murrells Inlet, South Carolina, United States, 29576
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Myrtle Beach, South Carolina, United States, 29572
United States, Tennessee
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Bartlett, Tennessee, United States, 38133
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Kingsport, Tennessee, United States, 37660
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Memphis, Tennessee, United States, 38163
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Nashville, Tennessee, United States, 37212
United States, Texas
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Arlington, Texas, United States, 76014
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Corpus Christi, Texas, United States, 78404
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Dallas, Texas, United States, 75230
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Dallas, Texas, United States, 75231
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Dallas, Texas, United States, 75246
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Dallas, Texas, United States, 75390
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Houston, Texas, United States, 77070
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Houston, Texas, United States, 77095
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Longview, Texas, United States, 75605
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Lubbock, Texas, United States, 79423
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Odessa, Texas, United States, 79761
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San Antonio, Texas, United States, 78228-3419
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San Antonio, Texas, United States, 78229
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Schertz, Texas, United States, 78154
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Tomball, Texas, United States, 77375
United States, Utah
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Salt Lake City, Utah, United States, 84102
United States, Vermont
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South Burlington, Vermont, United States, 05403
United States, Washington
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Spokane, Washington, United States, 99210
United States, Wisconsin
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Madison, Wisconsin, United States, 53717
Australia, New South Wales
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Blacktown, New South Wales, Australia, 2148
Australia, Queensland
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Douglas, Queensland, Australia, 4814
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Herston, Queensland, Australia, 4029
Novo Nordisk Investigational Site
Meadowbrook, Queensland, Australia, 4131
Australia, South Australia
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Daw Park, South Australia, Australia, 5041
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Keswick, South Australia, Australia, 5035
Australia, Tasmania
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Hobart, Tasmania, Australia, 7000
Australia, Victoria
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Box Hill, Victoria, Australia, 3128
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Fitzroy, Victoria, Australia, 3065
Australia, Western Australia
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Fremantle, Western Australia, Australia, 6160
Austria
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Graz, Austria, 8036
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Wien, Austria, 1030
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Wien, Austria, 1090
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Wien, Austria, 1130
Novo Nordisk Investigational Site
Wien, Austria, 1140
Belgium
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Edegem, Belgium, 2650
Novo Nordisk Investigational Site
Gent, Belgium, 9000
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Leuven, Belgium, 3000
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Liège, Belgium, 4000
Brazil
Novo Nordisk Investigational Site
Fortaleza, Ceara, Brazil, 60115-282
Novo Nordisk Investigational Site
Fortaleza, Ceara, Brazil, 60160-230
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Fortaleza, Ceara, Brazil, 60170-001
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Aparecida de Goiania, Goias, Brazil, 74935-530
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Curitiba, Parana, Brazil, 80010-030
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Curitiba, Parana, Brazil, 80030-110
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Belém, Para, Brazil, 66073-000
Novo Nordisk Investigational Site
Caxias Do Sul, Rio Grande do Sul, Brazil, 95070-560
Novo Nordisk Investigational Site
Porto Alegre, Rio Grande do Sul, Brazil, 90035-001
Novo Nordisk Investigational Site
Campinas, Sao Paulo, Brazil, 13059-740
Novo Nordisk Investigational Site
Campinas, Sao Paulo, Brazil, 13073-350
Novo Nordisk Investigational Site
São Paulo, Sao Paulo, Brazil, 01223-001
Novo Nordisk Investigational Site
São Paulo, Sao Paulo, Brazil, 01228-000
Novo Nordisk Investigational Site
São Paulo, Sao Paulo, Brazil, 01244-030
Novo Nordisk Investigational Site
São Paulo, Sao Paulo, Brazil, 04020-041
Novo Nordisk Investigational Site
São Paulo, Sao Paulo, Brazil, 05403-000
Novo Nordisk Investigational Site
Aracajú, Brazil, 49020-270
Novo Nordisk Investigational Site
Belo Horizonte, Brazil, 30150-221
Novo Nordisk Investigational Site
Campinas, Brazil, 13084-971
Novo Nordisk Investigational Site
Curitiba, Brazil, 80420-011
Novo Nordisk Investigational Site
Curitiba, Brazil, 80810-040
Novo Nordisk Investigational Site
Fortaleza, Brazil, 60430-350
Novo Nordisk Investigational Site
Goiânia, Brazil, 74110-120
Novo Nordisk Investigational Site
Joinville, Brazil, 05001-100
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Marília, Brazil, 17519-000
Novo Nordisk Investigational Site
Mogi Das Cruzes, Brazil, 08780-090
Novo Nordisk Investigational Site
Porto Alegre, Brazil, 90035-170
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Recife, Brazil, 52020-010
Novo Nordisk Investigational Site
Rio de Janeiro, Brazil, 20211-340
Novo Nordisk Investigational Site
Rio de Janeiro, Brazil, 20551-030
Novo Nordisk Investigational Site
Santos, Brazil, 11045-904
Novo Nordisk Investigational Site
Sao Paulo, Brazil, 01323-001
Novo Nordisk Investigational Site
Sao Paulo, Brazil, 04011-030
Novo Nordisk Investigational Site
Sao Paulo, Brazil, 04012-909
Novo Nordisk Investigational Site
São Paulo, Brazil, 05403-000
Canada, Alberta
Novo Nordisk Investigational Site
Edmonton, Alberta, Canada, T5J 3N4
Canada, British Columbia
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Vancouver, British Columbia, Canada, V6H 3X8
Canada, Manitoba
Novo Nordisk Investigational Site
Winnipeg, Manitoba, Canada, R3E 3P4
Canada, Newfoundland and Labrador
Novo Nordisk Investigational Site
St.John's, Newfoundland and Labrador, Canada, A1B 3V6
Canada, Nova Scotia
Novo Nordisk Investigational Site
Halifax, Nova Scotia, Canada, B3H 2Y9
Canada, Ontario
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Cambridge, Ontario, Canada, N1R 7L6
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Cornwall, Ontario, Canada, K6H 4M4
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London, Ontario, Canada, N6A 4V2
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London, Ontario, Canada, N6G 2M1
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Mississauga, Ontario, Canada, L5M 2V8
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Scarborough, Ontario, Canada, M1E 5E9
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Smiths Falls, Ontario, Canada, K7A 4W8
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Thunder Bay, Ontario, Canada, P7A 4V7
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Toronto, Ontario, Canada, M5C 2T2
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Toronto, Ontario, Canada, M5T 3L9
Canada, Quebec
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Montreal, Quebec, Canada, H2W 1R7
Canada
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Quebec, Canada, G1V 4G2
Novo Nordisk Investigational Site
Quebec, Canada, G1V 4G5
China, Beijing
Novo Nordisk Investigational Site
Beijing, Beijing, China, 100044
Novo Nordisk Investigational Site
Beijing, Beijing, China, 100730
Novo Nordisk Investigational Site
Beijing, Beijing, China, 100853
China, Fujian
Novo Nordisk Investigational Site
Xiamen, Fujian, China, 361003
China, Guangdong
Novo Nordisk Investigational Site
Guangzhou, Guangdong, China, 510120
China, Jiangsu
Novo Nordisk Investigational Site
Zhenjiang, Jiangsu, China, 212001
China, Shandong
Novo Nordisk Investigational Site
Qingdao, Shandong, China, 266003
China, Shanghai
Novo Nordisk Investigational Site
Shanghai, Shanghai, China, 200003
Czech Republic
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Plzen, Czech Republic, 304 60
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Praha, Czech Republic, 128 08
Denmark
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Aalborg, Denmark, 9100
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Esbjerg, Denmark, 6700
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Gentofte, Denmark, 2820
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Hvidovre, Denmark, 2650
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Odense, Denmark, 5000
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Århus C, Denmark, 8000
Finland
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Kuopio, Finland, 70210
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Lahti, Finland, 15110
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Oulu, Finland, 90029
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Tampere, Finland, 33520
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Vantaa, Finland, FIN-01600
France
Novo Nordisk Investigational Site
Corbeil Essonnes, France, 91106
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Jarny, France, 54800
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Nimes, France, 30006
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Paris, France, 75877
Germany
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Angermünde/OT Wolletz, Germany, 16278
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Aschaffenburg, Germany, 63739
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Berlin, Germany, 12163
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Berlin, Germany, 13055
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Dillingen, Germany, 89407
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Dresden, Germany, 01219
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Elsterwerda, Germany, 04910
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Essen, Germany, 45219
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Falkensee, Germany, 14612
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Gifhorn, Germany, 38518
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Hamburg, Germany, 22587
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Karlsbad, Germany, 76307
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Leipzig, Germany, 04103
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Leipzig, Germany, 04275
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Ludwigshafen, Germany, 67059
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Mannheim, Germany, 68163
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München, Germany, 80336
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Oldenburg, Germany, 23758
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Schkeuditz, Germany, 04435
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Schweinfurt, Germany, 97421
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St. Ingbert, Germany, 66386
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Ulm, Germany, 89081
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Villingen-Schwenningen, Germany, 78048
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Wangen, Germany, 88239
Greece
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Athens, Greece, GR-10552
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Athens, Greece, GR-11527
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Crete, Greece, 71001
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Thessaloniki, Greece, GR-57001
India
Novo Nordisk Investigational Site
Hyderabad, Andhra Pradesh, India, 500034
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Hyderbad, Andhra Pradesh, India, 500 012
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Guwahati, Assam, India, 781007
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Karnal, Haryana, India, 132001
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Bangalore, Karnataka, India, 560 003
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Bangalore, Karnataka, India, 560043
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Bangalore, Karnataka, India, 560052
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Manipal, Karnataka, India, 576104
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Kochi, Kerala, India, 682041
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Indore, Madhya Pradesh, India, 452010
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Mumbai, Maharashtra, India, 400012
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Chandigarh, Punjab, India, 160012
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Chennai, Tamil Nadu, India, 600029
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Chennai, Tamil Nadu, India, 600086
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Madurai, Tamil Nadu, India, 625 020
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Vellore, Tamil Nadu, India, 632004
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Kolkata, West Bengal, India, 700054
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Thriruvananthapuram, India, 695 032
Ireland
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Dublin 9, Ireland
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Dublin, Ireland, DUBLIN 4
Israel
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Haifa, Israel, 31096
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Haifa, Israel, 35152
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Jerusalem, Israel, 91120
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Petah-Tikva, Israel, 49372
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Tel Hashomer, Israel, 52621
Italy
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Bologna, Italy, 40138
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Catanzaro, Italy, 88100
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Chieti Scalo, Italy, 66100
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Firenze, Italy, 50141
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Latina, Italy, 04100
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Lucca, Italy, 55100
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Milano, Italy, 20132
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Padova, Italy, 35128
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Palermo, Italy, 90127
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Roma, Italy, 00133
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Roma, Italy, 00161
Korea, Republic of
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Goyang, Korea, Republic of, 410-719
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Seoul, Korea, Republic of, 130-701
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Seoul, Korea, Republic of, 137-701
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Seoul, Korea, Republic of, 139-827
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Sungnam, Korea, Republic of, 463-707
Mexico
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Tijuana, Baja California Norte, Mexico, 22010
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Guadalajara, Jalisco, Mexico, 44600
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Guadalajara, Jalisco, Mexico, 44650
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Aguascalientes, Mexico, 20230
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Durango, Mexico, 34000
Novo Nordisk Investigational Site
Durango, Mexico, 34080
Novo Nordisk Investigational Site
Monterrey, Mexico, 64460
Novo Nordisk Investigational Site
San Luis Potosi, Mexico, 78200
Netherlands
Novo Nordisk Investigational Site
Amsterdam, Netherlands, 1066 EC
Novo Nordisk Investigational Site
Eindhoven, Netherlands, 5631 BM
Novo Nordisk Investigational Site
Etten-Leur, Netherlands, 4872 LP
Novo Nordisk Investigational Site
Goes, Netherlands, 4461 LT
Novo Nordisk Investigational Site
Groningen, Netherlands, 9728 NT
Novo Nordisk Investigational Site
Hoogeveen, Netherlands, 7909 AA
Novo Nordisk Investigational Site
Maastricht, Netherlands, 6229 HX
Novo Nordisk Investigational Site
Nijmegen, Netherlands, 6525 GA
Novo Nordisk Investigational Site
Utrecht, Netherlands, 3584 CX
Norway
Novo Nordisk Investigational Site
Oslo, Norway, 0407
Novo Nordisk Investigational Site
Oslo, Norway, 0586
Novo Nordisk Investigational Site
Stavanger, Norway, 4011
Novo Nordisk Investigational Site
Trondheim, Norway, 7030
Novo Nordisk Investigational Site
Tønsberg, Norway, 3117
Poland
Novo Nordisk Investigational Site
Bialystok, Poland, 15-435
Novo Nordisk Investigational Site
Bydgoszcz, Poland, 85-822
Novo Nordisk Investigational Site
Katowice, Poland, 40-084
Novo Nordisk Investigational Site
Krakow, Poland, 31-261
Novo Nordisk Investigational Site
Krakow, Poland, 31-271
Novo Nordisk Investigational Site
Krakow, Poland, 31-501
Novo Nordisk Investigational Site
Lodz, Poland, 93-338
Novo Nordisk Investigational Site
Poznan, Poland, 60-569
Novo Nordisk Investigational Site
Pulawy, Poland, 24-100
Novo Nordisk Investigational Site
Ruda Slaska, Poland, 41-709
Novo Nordisk Investigational Site
Warszawa, Poland, 01-192
Novo Nordisk Investigational Site
Warszawa, Poland, 02-507
Novo Nordisk Investigational Site
Wroclaw, Poland, 50-088
Puerto Rico
Novo Nordisk Investigational Site
Bayamon, Puerto Rico, 00961
Novo Nordisk Investigational Site
Caguas, Puerto Rico, 00725
Romania
Novo Nordisk Investigational Site
Craiova, Dolj, Romania, 200642
Novo Nordisk Investigational Site
Targu Mures, Mures, Romania, 540098
Novo Nordisk Investigational Site
Bacau, Romania, 600114
Novo Nordisk Investigational Site
Bucharest, Romania, 020475
Novo Nordisk Investigational Site
Constanta, Romania, 900591
Novo Nordisk Investigational Site
Deva, Romania, 330084
Novo Nordisk Investigational Site
Iasi, Romania, 700547
Novo Nordisk Investigational Site
Satu Mare, Romania, 440055
Novo Nordisk Investigational Site
Sibiu, Romania, 550245
Novo Nordisk Investigational Site
Timisoara, Romania, 300736
Russian Federation
Novo Nordisk Investigational Site
Arkhangelsk, Russian Federation, 163001
Novo Nordisk Investigational Site
Arkhangelsk, Russian Federation, 163045
Novo Nordisk Investigational Site
Barnaul, Russian Federation, 656045
Novo Nordisk Investigational Site
Kazan, Russian Federation, 420043
Novo Nordisk Investigational Site
Moscow, Russian Federation, 117036
Novo Nordisk Investigational Site
Moscow, Russian Federation, 119435
Novo Nordisk Investigational Site
Moscow, Russian Federation, 125367
Novo Nordisk Investigational Site
Moscow, Russian Federation, 127486
Novo Nordisk Investigational Site
Nizhniy Novgorod, Russian Federation, 603126
Novo Nordisk Investigational Site
Penza, Russian Federation, 440026
Novo Nordisk Investigational Site
Saratov, Russian Federation, 410053
Novo Nordisk Investigational Site
Smolensk, Russian Federation, 214019
Novo Nordisk Investigational Site
Tumen, Russian Federation, 625023
Novo Nordisk Investigational Site
Yaroslavl, Russian Federation, 150062
Serbia
Novo Nordisk Investigational Site
Belgrade, Serbia, 11000
South Africa
Novo Nordisk Investigational Site
Bloemfontein, Free State, South Africa, 9301
Novo Nordisk Investigational Site
Johannesburg, Gauteng, South Africa, 1829
Novo Nordisk Investigational Site
Johannesburg, Gauteng, South Africa, 2013
Novo Nordisk Investigational Site
Lenasia, Gauteng, South Africa, 1827
Novo Nordisk Investigational Site
Midrand, Gauteng, South Africa, 1685
Novo Nordisk Investigational Site
Pretoria, Gauteng, South Africa, 0001
Novo Nordisk Investigational Site
Pretoria, Gauteng, South Africa, 0083
Novo Nordisk Investigational Site
Pretoria, Gauteng, South Africa, 0181
Novo Nordisk Investigational Site
Durban, KwaZulu-Natal, South Africa, 4091
Novo Nordisk Investigational Site
Durban, KwaZulu-Natal, South Africa, 4126
Novo Nordisk Investigational Site
Durban, KwaZulu-Natal, South Africa, 4320
Novo Nordisk Investigational Site
Tongaat, KwaZulu-Natal, South Africa, 4400
Novo Nordisk Investigational Site
Cape Town, Western Cape, South Africa
Novo Nordisk Investigational Site
Somerset West, Western Cape, South Africa, 7130
Novo Nordisk Investigational Site
Alberton, South Africa, 1449
Novo Nordisk Investigational Site
Cape Town, South Africa, 7530
Spain
Novo Nordisk Investigational Site
Almería, Spain, 04001
Novo Nordisk Investigational Site
Barcelona, Spain, 08036
Novo Nordisk Investigational Site
La Coruña, Spain, 15006
Novo Nordisk Investigational Site
Madrid, Spain, 28040
Novo Nordisk Investigational Site
Mora de Ebre, Spain, 43740
Novo Nordisk Investigational Site
Mostoles - Madrid -, Spain, 28935
Novo Nordisk Investigational Site
Palma de Mallorca, Spain, 07198
Novo Nordisk Investigational Site
Pozuelo de Alarcon, Spain, 28223
Novo Nordisk Investigational Site
Sevilla, Spain, 41003
Novo Nordisk Investigational Site
Sevilla, Spain, 41014
Novo Nordisk Investigational Site
Valladolid, Spain, 47005
Sweden
Novo Nordisk Investigational Site
Göteborg, Sweden, 413 45
Novo Nordisk Investigational Site
Malmö, Sweden, 205 02
Novo Nordisk Investigational Site
Stockholm, Sweden, 111 57
Novo Nordisk Investigational Site
Stockholm, Sweden, 113 24
Novo Nordisk Investigational Site
Stockholm, Sweden, 141 86
Novo Nordisk Investigational Site
Örebro, Sweden, 701 85
Taiwan
Novo Nordisk Investigational Site
Changhua, Taiwan, 500
Novo Nordisk Investigational Site
Kaoshiung, Taiwan, 807
Novo Nordisk Investigational Site
Tainan city, Taiwan, 710
Novo Nordisk Investigational Site
Taoyuan, Taiwan, 333
Turkey
Novo Nordisk Investigational Site
Ankara, Turkey, 06100
Novo Nordisk Investigational Site
Ankara, Turkey, 06500
Novo Nordisk Investigational Site
Antalya, Turkey, 07058
Novo Nordisk Investigational Site
Bursa, Turkey, 16059
Novo Nordisk Investigational Site
Gaziantep, Turkey, 27070
Novo Nordisk Investigational Site
Istanbul, Turkey, 34096
Novo Nordisk Investigational Site
Istanbul, Turkey, 34098
Novo Nordisk Investigational Site
Istanbul, Turkey, 34360
Novo Nordisk Investigational Site
Istanbul, Turkey, 34371
Novo Nordisk Investigational Site
Istanbul, Turkey, 34390
Novo Nordisk Investigational Site
Istanbul, Turkey, 34722
Novo Nordisk Investigational Site
Istanbul, Turkey, 34890
Novo Nordisk Investigational Site
Istanbul, Turkey
Novo Nordisk Investigational Site
Izmir, Turkey, 35100
Novo Nordisk Investigational Site
Izmir, Turkey, 35340
Novo Nordisk Investigational Site
Kayseri, Turkey, 38039
United Arab Emirates
Novo Nordisk Investigational Site
Dubai, United Arab Emirates, 4545
Novo Nordisk Investigational Site
Dubai, United Arab Emirates, 7272
United Kingdom
Novo Nordisk Investigational Site
Aberdeen, United Kingdom, AB25 1LD
Novo Nordisk Investigational Site
Birmingham, United Kingdom, B9 5SS
Novo Nordisk Investigational Site
Bristol, United Kingdom, BS10 5NB
Novo Nordisk Investigational Site
Coventry, United Kingdom, CV2 2DX
Novo Nordisk Investigational Site
Devon, United Kingdom, EX2 5DW
Novo Nordisk Investigational Site
Dundee, United Kingdom, DD1 9SY
Novo Nordisk Investigational Site
Edinburgh, United Kingdom, EH16 4SA
Novo Nordisk Investigational Site
Glasgow, United Kingdom, G31 2ER
Novo Nordisk Investigational Site
Guildford, United Kingdom, GU2 7XX
Novo Nordisk Investigational Site
Hull, United Kingdom, HU3 2RW
Novo Nordisk Investigational Site
Livington, United Kingdom, EH54 6PP
Novo Nordisk Investigational Site
London, United Kingdom, W2 1NY
Novo Nordisk Investigational Site
Manchester, United Kingdom, M6 8HD
Novo Nordisk Investigational Site
Norwich, United Kingdom, NR4 7TJ
Novo Nordisk Investigational Site
Nuneaton, United Kingdom, CV10 7DJ
Novo Nordisk Investigational Site
Plymouth, United Kingdom, PL6 8BQ
Novo Nordisk Investigational Site
St Helens, United Kingdom, WA9 3DA
Novo Nordisk Investigational Site
Swansea, United Kingdom, SA6 6NL
Novo Nordisk Investigational Site
Torquay, United Kingdom, TQ2 7AA
Novo Nordisk Investigational Site
West Midlands, United Kingdom, B71 4HJ
Sponsors and Collaborators
Novo Nordisk A/S
Investigators
Study Director: Global Clinical Registry (GCR, 1452) Novo Nordisk A/S
  More Information

Additional Information:
Publications:

Responsible Party: Novo Nordisk A/S
ClinicalTrials.gov Identifier: NCT01179048     History of Changes
Other Study ID Numbers: EX2211-3748
2009-012201-19 ( EudraCT Number )
U1111-1113-7090 ( Other Identifier: WHO )
CTR20130003 ( Other Identifier: CFDA )
Study First Received: August 6, 2010
Results First Received: December 16, 2016
Last Updated: January 10, 2017

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Liraglutide
Hypoglycemic Agents
Physiological Effects of Drugs
Incretins
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists

ClinicalTrials.gov processed this record on March 27, 2017