Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
AstraZeneca
ClinicalTrials.gov Identifier:
NCT01144338
First received: June 10, 2010
Last updated: May 4, 2015
Last verified: May 2015
  Purpose

This study will compare the impact of including exenatide once weekly in addition to usual care vs. usual care without exenatide on major cardiovascular outcomes as measured by the primary composite endpoint of cardiovascular-related death, nonfatal myocardial infarction (MI), or nonfatal stroke.


Condition Intervention Phase
Type 2 Diabetes Mellitus
Drug: Exenatide Once Weekly
Drug: Placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL). A Randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly in Patients With Type 2 Diabetes Mellitus.

Resource links provided by NLM:


Further study details as provided by AstraZeneca:

Primary Outcome Measures:
  • The primary efficacy outcome variable is defined as the composite endpoint of cardiovascular death, nonfatal MI, or nonfatal stroke [ Time Frame: Time to first event. Information collected during study period (anticipated to be up to 7.5 years). ] [ Designated as safety issue: No ]
  • The primary safety outcome variable is defined as the composite endpoint of cardiovascular death, nonfatal MI, or nonfatal stroke. [ Time Frame: Time to first event. Information collected during study period (anticipated to be up to 7.5 years). ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • All-cause mortality [ Time Frame: Time to event. Information collected during study period (anticipated to be up to 7.5 years). ] [ Designated as safety issue: No ]
  • Components of the primary composite endpoint (cardiovascular death, fatal or nonfatal MI, fatal or nonfatal stroke). [ Time Frame: Time to first event. Information collected during study period (anticipated to be up to 7.5 years). ] [ Designated as safety issue: No ]
  • Hospitalization for acute coronary syndrome [ Time Frame: Time to first event. Information collected during study period (anticipated to be up to 7.5 years). ] [ Designated as safety issue: No ]
  • Hospitalization for heart failure [ Time Frame: Time to first event. Information collected during study period (anticipated to be up to 7.5 years). ] [ Designated as safety issue: No ]

Estimated Enrollment: 14000
Study Start Date: June 2010
Estimated Study Completion Date: April 2018
Estimated Primary Completion Date: April 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exenatide Once Weekly Drug: Exenatide Once Weekly
Subcutaneous injection, 2 mg, administered once weekly.
Placebo Comparator: Placebo Drug: Placebo
Subcutaneous injection, matching volume of placebo, administered once weekly.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patient has type 2 diabetes mellitus
  • Patient has an HbA1c of ≥ 6.5 % and ≤ 10.0% and is currently using one of the following treatment regimens: A) Treatment with 0-3 oral antihyperglycemic agents B) Insulin therapy, either alone or in combination with up to two oral agents
  • Female patients must not be breast feeding and agree to use an effective method of contraception or must not otherwise be at risk of becoming pregnant.

Exclusion Criteria:

  • Patient has a diagnosis of type 1 diabetes mellitus, or a history of ketoacidosis.
  • Patient has ever been treated with an approved or investigational GLP-1 receptor agonist.
  • Patient is enrolled in another experimental protocol which involves the use of an investigational drug or device, or an intervention that would interfere with the conduct of the trial.
  • Patient has a planned or anticipated revascularization procedure.
  • Pregnancy or planned pregnancy during the trial period.
  • Patient has end-stage renal disease or an estimated glomerular filtration rate (eGFR) of <30 mL/min/1.73m2.
  • Patient has a history of gastroparesis or pancreatitis.
  • Personal or family history of medullary thyroid cancer or MEN2 (Multiple EndocrineNeoplasia Type 2) or calcitonin level of >40 ng/L at baseline.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01144338

  Hide Study Locations
Locations
United States, Alabama
Research Site
Birmingham, Alabama, United States
United States, Arizona
Research Site
Glendale, Arizona, United States
Research Site
Phoenix, Arizona, United States
Research Site
Tuscon, Arizona, United States
United States, Arkansas
Research Site
Jonesboro, Arkansas, United States
Research Site
Little Rock, Arkansas, United States
United States, California
Research Site
Chula Vista, California, United States
Research Site
Concord, California, United States
Research Site
Escondido, California, United States
Research Site
Fullerton, California, United States
Research Site
Greenbrae, California, United States
Research Site
Huntington Beach, California, United States
Research Site
La Mesa, California, United States
Research Site
Laguna Hills, California, United States
Research Site
Long Beach, California, United States
Research Site
Los Angeles, California, United States
Research Site
Northridge, California, United States
Research Site
Oceanside, California, United States
Research Site
Orange, California, United States
Research Site
Redondo Beach, California, United States
Research Site
San Diego, California, United States
Research Site
Sylmar, California, United States
Research Site
Torrance, California, United States
Research Site
Tustin, California, United States
Research Site
Victorville, California, United States
United States, Colorado
Research Site
Aurora, Colorado, United States
Research Site
Colorado Springs, Colorado, United States
Research Site
Littleton, Colorado, United States
United States, Connecticut
Research Site
Thomaston, Connecticut, United States
United States, District of Columbia
Research Site
Washington, District of Columbia, United States
United States, Florida
Research Site
Cape Coral, Florida, United States
Research Site
Ft. Lauderdale, Florida, United States
Research Site
Jacksonville, Florida, United States
Research Site
Sarasota, Florida, United States
United States, Georgia
Research Site
Atlanta, Georgia, United States
Research Site
Decatur, Georgia, United States
Research Site
Marietta, Georgia, United States
Research Site
Roswell, Georgia, United States
United States, Idaho
Research Site
Pocatello, Idaho, United States
United States, Illinois
Research Site
Chicago, Illinois, United States
Research Site
Hines, Illinois, United States
Research Site
Rock Island, Illinois, United States
Research Site
Springfield, Illinois, United States
United States, Indiana
Research Site
Avon, Indiana, United States
Research Site
Gary, Indiana, United States
Research Site
Greenfield, Indiana, United States
Research Site
Indianapolis, Indiana, United States
United States, Iowa
Research Site
Des Moines, Iowa, United States
United States, Kansas
Research Site
Kansas City, Kansas, United States
United States, Kentucky
Research Site
Covington, Kentucky, United States
Research Site
Evansville, Kentucky, United States
Research Site
Lexington, Kentucky, United States
United States, Louisiana
Research Site
Alexandria, Louisiana, United States
United States, Maine
Research Site
Auburn, Maine, United States
United States, Maryland
Research Site
Baltimore, Maryland, United States
Research Site
Randallstown, Maryland, United States
Research Site
Rockville, Maryland, United States
United States, Michigan
Research Site
Alpena, Michigan, United States
Research Site
Ann Arbor, Michigan, United States
Research Site
Bloomfield Hills, Michigan, United States
Research Site
Detroit, Michigan, United States
United States, Minnesota
Research Site
Duluth, Minnesota, United States
Research Site
Minneapolis, Minnesota, United States
Research Site
St Cloud, Minnesota, United States
United States, Missouri
Research Site
Bridgeton, Missouri, United States
Research Site
Chesterfield, Missouri, United States
Research Site
Kansas City, Missouri, United States
United States, Montana
Research Site
Billings, Montana, United States
Research Site
Butte, Montana, United States
United States, Nebraska
Research Site
Omaha, Nebraska, United States
United States, Nevada
Research Site
Las Vegas, Nevada, United States
Research Site
Reno, Nevada, United States
United States, New Jersey
Research Site
Haddon Heights, New Jersey, United States
Research Site
Hamilton, New Jersey, United States
Research Site
Lyons, New Jersey, United States
Research Site
Margate, New Jersey, United States
Research Site
South Plainfield, New Jersey, United States
United States, New York
Research Site
Albany, New York, United States
Research Site
Bronx, New York, United States
Research Site
Manhasset, New York, United States
Research Site
New York, New York, United States
Research Site
North Massapequa, New York, United States
Research Site
Rosedale, New York, United States
Research Site
Smithtown, New York, United States
United States, North Carolina
Research Site
Charlotte, North Carolina, United States
Research Site
Durham, North Carolina, United States
Research Site
Greensboro, North Carolina, United States
Research Site
Hickory, North Carolina, United States
Research Site
Jacksonville, North Carolina, United States
Research Site
Mooresville, North Carolina, United States
Research Site
Morehead City, North Carolina, United States
Research Site
Raleigh, North Carolina, United States
Research Site
Salisbury, North Carolina, United States
Research Site
Statesville, North Carolina, United States
Research Site
Wilmington, North Carolina, United States
Research Site
Winston-Salem, North Carolina, United States
United States, North Dakota
Research Site
Fargo, North Dakota, United States
United States, Ohio
Research Site
Barberton, Ohio, United States
Research Site
Canal Fulton, Ohio, United States
Research Site
Cleveland, Ohio, United States
Research Site
Columbus, Ohio, United States
Research Site
Kettering, Ohio, United States
Research Site
Mentor, Ohio, United States
Research Site
Toledo, Ohio, United States
United States, Oklahoma
Research Site
Oklahoma City, Oklahoma, United States
United States, Pennsylvania
Research Site
Altoona, Pennsylvania, United States
Research Site
Bethlehem, Pennsylvania, United States
Research Site
Feasterville, Pennsylvania, United States
Research Site
Lansdale, Pennsylvania, United States
Research Site
Newport, Pennsylvania, United States
Research Site
Penndel, Pennsylvania, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Tipton, Pennsylvania, United States
United States, Rhode Island
Research Site
Pawtucket, Rhode Island, United States
United States, South Carolina
Research Site
Charleston, South Carolina, United States
Research Site
Mount Pleasant, South Carolina, United States
Research Site
Murrells Inlet, South Carolina, United States
United States, South Dakota
Research Site
Rapid City, South Dakota, United States
United States, Tennessee
Research Site
Bristol, Tennessee, United States
Research Site
Chattanooga, Tennessee, United States
Research Site
Jackson, Tennessee, United States
Research Site
Johnson City, Tennessee, United States
Research Site
Kingsport, Tennessee, United States
Research Site
Knoxville, Tennessee, United States
Research Site
McKenzie, Tennessee, United States
Research Site
Nashville, Tennessee, United States
United States, Texas
Research Site
Arlington, Texas, United States
Research Site
Dallas, Texas, United States
Research Site
El Paso, Texas, United States
Research Site
Friendswood, Texas, United States
Research Site
Houston, Texas, United States
Research Site
San Antonio, Texas, United States
Research Site
Webster, Texas, United States
United States, Utah
Research Site
Layton, Utah, United States
United States, Washington
Research Site
Spokane, Washington, United States
Argentina
Research Site
Buenos Aires, Argentina
Research Site
Caba, Argentina
Research Site
Capital Federal, Argentina
Research Site
CiudadAutonoma de Buenos Aires, Argentina
Research Site
Cordoba, Argentina
Research Site
Godoy Cruz, Argentina
Research Site
Jujuy, Argentina
Research Site
Mar del Plata Buenos Aires, Argentina
Research Site
Rosario, Argentina
Research Site
Salta, Argentina
Research Site
San Miguel de Tucuman, Argentina
Research Site
Santa Rosa, Argentina
Australia
Research Site
Adelaide, Australia
Research Site
Camperdown, Australia
Research Site
Clayton, Australia
Research Site
Elizabeth Vale, Australia
Research Site
Fitzroy, Australia
Research Site
Forresters Beach, Australia
Research Site
Garran, Australia
Research Site
Geelong, Australia
Research Site
Heidelberg West, Australia
Research Site
Meadobank, Australia
Research Site
Milton, Australia
Research Site
Parkville, Australia
Research Site
Sydney, Australia
Austria
Research Site
Feldkirch, Austria
Research Site
Graz, Austria
Research Site
Innsbruck, Austria
Research Site
Salzburg, Austria
Research Site
Wien, Austria
Research Site
Zams, Austria
Belgium
Research Site
Bruxelles, Belgium
Research Site
Leuven, Belgium
Research Site
Merksem, Belgium
Research Site
Ronse, Belgium
Brazil
Research Site
Aparecida de Goiânia, Brazil
Research Site
Belém, Brazil
Research Site
Brasilia, Brazil
Research Site
Campinas, Brazil
Research Site
Curitiba, Brazil
Research Site
Fortaleza, Brazil
Research Site
Goiânia, Brazil
Research Site
Marília, Brazil
Research Site
Passo Fundo, Brazil
Research Site
Recife, Brazil
Research Site
Sao Paulo, Brazil
Research Site
São Paulo, Brazil
Bulgaria
Research Site
Blagoevgrad, Bulgaria
Research Site
Gabrovo, Bulgaria
Research Site
Gulyantsi, Bulgaria
Research Site
Plovdiv, Bulgaria
Research Site
Sevlievo, Bulgaria
Research Site
Sliven, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Stara Zagora, Bulgaria
Canada, Alberta
Research Site
Calgary, Alberta, Canada
Canada, British Columbia
Research Site
Delta, British Columbia, Canada
Research Site
New Westminster, British Columbia, Canada
Research Site
Surrey, British Columbia, Canada
Research Site
Vancouver, British Columbia, Canada
Canada, Manitoba
Research Site
Winnipeg, Manitoba, Canada
Canada, New Brunswick
Research Site
Moncton, New Brunswick, Canada
Canada, Nova Scotia
Research Site
Bridgewater, Nova Scotia, Canada
Research Site
Liverpool, Nova Scotia, Canada
Canada, Ontario
Research Site
Cambridge, Ontario, Canada
Research Site
Guelph, Ontario, Canada
Research Site
Hamilton, Ontario, Canada
Research Site
Kitchener, Ontario, Canada
Research Site
London, Ontario, Canada
Research Site
North York, Ontario, Canada
Research Site
Ottawa, Ontario, Canada
Research Site
Scarborough, Ontario, Canada
Research Site
Smiths Falls, Ontario, Canada
Research Site
Toronto, Ontario, Canada
Canada, Quebec
Research Site
Laval, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Terrebonne, Quebec, Canada
Canada
Research Site
Quebec, Canada
Chile
Research Site
Osorno, Chile
Research Site
Puerto Varas, Chile
Research Site
Santiago, Chile
Research Site
Temuco, Chile
Research Site
Vina del Mar, Chile
China
Research Site
Beijing, China
Research Site
Changsha, China
Research Site
Chongqing, China
Research Site
Chuangchun, China
Research Site
Guangzhou, China
Research Site
Guiyang, China
Research Site
Hangzhou, China
Research Site
Hong Kong, China
Research Site
Nanchang, China
Research Site
Nanjing, China
Research Site
Nanning, China
Research Site
Shanghai, China
Research Site
Shengyang, China
Research Site
Shijiazhuang, China
Research Site
Siping, China
Research Site
Suzhou, China
Research Site
Tianjin, China
Research Site
Wenzhou, China
Research Site
Wuhan, China
Research Site
Xian, China
Research Site
Yueyang, China
Colombia
Research Site
Barranquilla, Colombia
Research Site
Bogotá, Colombia
Research Site
Bogotá D.C., Colombia
Research Site
Cali, Colombia
Research Site
Manizales, Colombia
Research Site
Medellin, Colombia
Research Site
Medellín, Colombia
Czech Republic
Research Site
Olomouc-Lazce, Czech Republic
Research Site
Praha 10, Prague, Czech Republic
Research Site
Praha 4, Czech Republic
Research Site
Svitavy, Czech Republic
Research Site
Znojmo, Czech Republic
Germany
Research Site
Aachen, Germany
Research Site
Aschaffenburg, Germany
Research Site
Bad Nauheim, Germany
Research Site
Bad Oeynhausen, Germany
Research Site
Berlin, Germany
Research Site
Bochum, Germany
Research Site
Burg, Germany
Research Site
Burghausen, Germany
Research Site
Chemnitz, Germany
Research Site
Dortmund, Germany
Research Site
Dresden, Germany
Research Site
Eschweiler, Germany
Research Site
Essen, Germany
Research Site
Gießen, Germany
Research Site
Herne, Germany
Research Site
Hohenmölsen, Germany
Research Site
Kassel, Germany
Research Site
Kiel-Kronshagen, Germany
Research Site
Köthen, Germany
Research Site
Lichtenfels, Germany
Research Site
Mainz, Germany
Research Site
Mayen, Germany
Research Site
München, Germany
Research Site
Münster, Germany
Research Site
Obermichelbach, Germany
Research Site
Osnabrueck, Germany
Research Site
Riesa, Germany
Research Site
Rotenburg, Germany
Research Site
Stuttgart, Germany
Research Site
Würzburg, Germany
Hong Kong
Research Site
Hong Kong, Hong Kong
Research Site
Shatin, Hong Kong
Hungary
Research Site
Balatonfüred, Hungary
Research Site
Budapest, Hungary
Research Site
Csongrad, Hungary
Research Site
Debrecen, Hungary
Research Site
Eger, Hungary
Research Site
Gyor, Hungary
Research Site
Hodmezovasarhely, Hungary
Research Site
Jászberény, Hungary
Research Site
Kaposvár, Hungary
Research Site
Kecskemét, Hungary
Research Site
Komarom, Hungary
Research Site
Mosonmagyarovar, Hungary
Research Site
Nagykanizsa, Hungary
Research Site
Nyíregyháza, Hungary
Research Site
Pápa, Hungary
Research Site
Pécs, Hungary
Research Site
Szekszárd, Hungary
Research Site
Szentes, Hungary
Research Site
Szigetvár, Hungary
Research Site
Szikszo, Hungary
Research Site
Székesfehérvár, Hungary
Research Site
Sátoraljaújhely, Hungary
Research Site
Veszprem, Hungary
Research Site
Zalaegerszeg, Hungary
Israel
Research Site
Givatayim, Israel
Research Site
Hadera, Israel
Research Site
Haifa, Israel
Research Site
Holon, Israel
Research Site
Jerusalem, Israel
Research Site
Kfar Saba, Israel
Research Site
Nahariya, Israel
Research Site
Nazareth, Israel
Research Site
Petah Tikva, Israel
Research Site
Safed, Israel
Research Site
Tel-Aviv, Israel
Italy
Research Site
Firenze, Italy
Research Site
Foggia, Italy
Research Site
Milano, Italy
Research Site
Pisa, Italy
Research Site
Roma, Italy
Research Site
Sesto San Giovanni, Italy
Research Site
Terni, Italy
Research Site
Udine, Italy
Korea, Republic of
Research Site
Busan, Korea, Republic of
Research Site
Daegu, Korea, Republic of
Research Site
Gwangjin-gu, Korea, Republic of
Research Site
Gyeonggi-do, Korea, Republic of
Research Site
Incheon, Korea, Republic of
Research Site
Seongnam-si, Korea, Republic of
Research Site
Seoul, Korea, Republic of
Research Site
Suwon, Korea, Republic of
Research Site
Suwon-si, Korea, Republic of
Research Site
Ulsan, Korea, Republic of
Latvia
Research Site
Daugavpils, Latvia
Research Site
Jelgava, Latvia
Research Site
Kuldiga, Latvia
Research Site
Ogre, Latvia
Research Site
Riga, Latvia
Research Site
Talsi, Latvia
Research Site
Tukums, Latvia
Lithuania
Research Site
Kaunas, Lithuania
Research Site
Kedainiai, Lithuania
Research Site
Klaipeda, Lithuania
Research Site
Panevezys, Lithuania
Research Site
Ukmerge, Lithuania
Research Site
Utena, Lithuania
Research Site
Vilnius, Lithuania
Malaysia
Research Site
Alor Setar, Malaysia
Research Site
Batu Caves, Malaysia
Research Site
Kota Samarahan, Malaysia
Research Site
Kuala Lumpur, Malaysia
Research Site
Kuching, Malaysia
Research Site
Sungai Buloh, Malaysia
Research Site
Taiping, Malaysia
Mexico
Research Site
Aguascalientes, Mexico
Research Site
Cuautla, Mexico
Research Site
Durango, Mexico
Research Site
Guadalajara, Mexico
Research Site
Mexico, Mexico
Research Site
Monterrey, Mexico
Research Site
Puebla, Mexico
Research Site
Queretaro, Mexico
Research Site
San Luis Potosí, Mexico
Netherlands
Research Site
Amersfoort, Netherlands
Research Site
Amsterdam, Netherlands
Research Site
Breda, Netherlands
Research Site
Eindhoven, Netherlands
Research Site
Groningen, Netherlands
Research Site
Hardenberg, Netherlands
Research Site
Hoogeveen, Netherlands
Research Site
Meppel, Netherlands
Research Site
Rotterdam, Netherlands
Research Site
Sneek, Netherlands
Research Site
Utrecht, Netherlands
Research Site
Velp, Netherlands
Research Site
Zoetermeer, Netherlands
New Zealand
Research Site
Christchurch, New Zealand
Research Site
Hamilton, New Zealand
Research Site
Nelson, New Zealand
Research Site
Newtown, New Zealand
Research Site
Palmerston North, New Zealand
Research Site
Takapuna, New Zealand
Research Site
Tauranga, New Zealand
Research Site
Wellington, New Zealand
Philippines
Research Site
Cebu, Philippines
Research Site
Iloilo City, Philippines
Research Site
Manila, Philippines
Research Site
Marikina, Philippines
Research Site
Marikina City, Philippines
Research Site
Pasig, Philippines
Research Site
Quezon, Philippines
Research Site
Quezon City, Philippines
Research Site
San Juan, Philippines
Poland
Research Site
Elbląg, Poland
Research Site
Gdynia, Poland
Research Site
Grodzisk Mazowiecki, Poland
Research Site
Grudziadz, Poland
Research Site
Katowice, Poland
Research Site
Lublin, Poland
Research Site
Ostrołęka, Poland
Research Site
Poznań, Poland
Research Site
Płock, Poland
Research Site
Słupsk, Poland
Research Site
Warszawa, Poland
Research Site
Wroclaw, Poland
Research Site
Wrocław, Poland
Research Site
Łask, Poland
Research Site
Łódź, Poland
Research Site
Łęczna, Poland
Romania
Research Site
Bacau, Romania
Research Site
Bucharest, Romania
Research Site
Bucuresti, Romania
Research Site
Buzau, Romania
Research Site
Cluj Napoca, Romania
Research Site
Craiova, Romania
Research Site
Iasi, Romania
Research Site
Oradea, Romania
Research Site
Ploiesti, Romania
Research Site
Satu-Mare, Romania
Research Site
Timisoara, Romania
Research Site
Timișoara, Romania
Research Site
Zalau, Romania
Russian Federation
Research Site
Ekaterinburg, Russian Federation
Research Site
Kemerovo, Russian Federation
Research Site
Krasnoyarsk, Russian Federation
Research Site
Moscow, Russian Federation
Research Site
Nizhnii Novgorod, Russian Federation
Research Site
Novosibirsk, Russian Federation
Research Site
Saint Petersburg, Russian Federation
Research Site
St. Peterburg, Russian Federation
Research Site
St.Рetersburg, Russian Federation
Research Site
Thymen, Russian Federation
Research Site
Tomsk, Russian Federation
Research Site
Yaroslavl, Russian Federation
Slovakia
Research Site
Bardejov, Slovakia
Research Site
Bratislava, Slovakia
Research Site
Kosice, Slovakia
Research Site
Lucenec, Slovakia
Research Site
Presov, Slovakia
Research Site
Roznava, Slovakia
Research Site
Trebisov, Slovakia
Research Site
Zilina, Slovakia
South Africa
Research Site
Boksburg, South Africa
Research Site
Brits, South Africa
Research Site
Cape Town, South Africa
Research Site
Centurion, South Africa
Research Site
Durban, South Africa
Research Site
Johannesburg, South Africa
Research Site
Kempton Park, South Africa
Research Site
Lenasia, South Africa
Research Site
Lynnwood Ridge, South Africa
Research Site
Paarl, South Africa
Research Site
Parktown, South Africa
Research Site
Phoenix, South Africa
Research Site
Port Elizabeth, South Africa
Research Site
Potchefstroom, South Africa
Research Site
Pretoria, South Africa
Research Site
Soweto, South Africa
Research Site
Umkomaas, South Africa
Spain
Research Site
A Coruña, Spain
Research Site
Alcalá de Henares, Spain
Research Site
Avila, Spain
Research Site
Ferrol, Spain
Research Site
Girona, Spain
Research Site
Granada, Spain
Research Site
Lleida, Spain
Research Site
Madrid, Spain
Research Site
Manacor, Spain
Research Site
Málaga, Spain
Research Site
Palma de Mallorca, Spain
Research Site
Palma deMallorca, Spain
Research Site
Salamanca, Spain
Research Site
Sevilla, Spain
Research Site
Tarragona, Spain
Taiwan
Research Site
Changhua, Taiwan
Research Site
Kaohsiung, Taiwan
Research Site
Kaohsiung Hsien, Taiwan
Research Site
Kweishan Shiang, Taiwan
Research Site
New Taipei City, Taiwan
Research Site
Taichung, Taiwan
Research Site
Tainan County, Taiwan
Research Site
Taipei, Taiwan
Thailand
Research Site
Bangkok, Thailand
Ukraine
Research Site
Chernivtsi, Ukraine
Research Site
Dnepropetrovsk, Ukraine
Research Site
Dnipropetrovsk, Ukraine
Research Site
Donetck, Ukraine
Research Site
Donetsk, Ukraine
Research Site
Ivano-Frankivsk, Ukraine
Research Site
Kharkiv, Ukraine
Research Site
Kiev, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Odesa, Ukraine
Research Site
Odessa, Ukraine
Research Site
Sumy, Ukraine
Research Site
Ternopil, Ukraine
Research Site
Uzhgorod, Ukraine
Research Site
Vinnytsia, Ukraine
Research Site
Zaporizhia, Ukraine
Research Site
Zaporizhzhya, Ukraine
Research Site
Zhytomyr, Ukraine
United Kingdom
Research Site
Aberdeen, United Kingdom
Research Site
Addlestone, United Kingdom
Research Site
Birmingham, United Kingdom
Research Site
Blackpool, United Kingdom
Research Site
Bradford, United Kingdom
Research Site
Bristol, United Kingdom
Research Site
Cambridge, United Kingdom
Research Site
Chippenham, United Kingdom
Research Site
Coventry, United Kingdom
Research Site
Dundee, United Kingdom
Research Site
Edinburgh, United Kingdom
Research Site
Glasgow, United Kingdom
Research Site
Hull, United Kingdom
Research Site
Inverness, United Kingdom
Research Site
Irvine, United Kingdom
Research Site
Leicester, United Kingdom
Research Site
Liverpool, United Kingdom
Research Site
Manchester, United Kingdom
Research Site
Northampton, United Kingdom
Research Site
Ormskirk, United Kingdom
Research Site
Peterborough, United Kingdom
Research Site
Plymouth, United Kingdom
Research Site
Redhill, United Kingdom
Research Site
Sheffield, United Kingdom
Research Site
Suffolk, United Kingdom
Research Site
Swansea, United Kingdom
Research Site
Trowbridge, United Kingdom
Research Site
West Sussex, United Kingdom
Sponsors and Collaborators
AstraZeneca
Investigators
Study Director: Nardev Khurmi, MD AstraZeneca
  More Information

No publications provided by AstraZeneca

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: AstraZeneca
ClinicalTrials.gov Identifier: NCT01144338     History of Changes
Other Study ID Numbers: D5551C00003, MB001-002, BCB109
Study First Received: June 10, 2010
Last Updated: May 4, 2015
Health Authority: United States: Food and Drug Administration

Keywords provided by AstraZeneca:
exenatide once weekly
cardiovascular
Bydureon
Amylin

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Endocrine System Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Exenatide
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Hypoglycemic Agents
Incretins
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on May 21, 2015