Antiarrythmic Drugs - Long-term Follow-up in the Modern Era
|ClinicalTrials.gov Identifier: NCT01082055|
Recruitment Status : Unknown
Verified March 2010 by University of Dundee.
Recruitment status was: Active, not recruiting
First Posted : March 5, 2010
Last Update Posted : March 5, 2010
Antiarrhythmic drugs are associated with significant side effect profiles. Amiodarone has primarily class III action and whilst it has unrivalled efficacy in management of certain arrhythmias, it has a formidable side effect profile. Complications of continued therapy include, thyroiditis, hepatitis, cholestasis, increased skin sensitivity and pulmonary fibrosis. Current prescribing guidelines recommend frequent blood tests to monitor kidney, liver and thyroid function, in addition to frequent pulmonary function tests. Sotalol is a betablocker which possesses class III action in high doses and may predispose to QT prolongation Other class I agents such as flecainide and propafenone can be associated with sudden cardiac death in certain populations, and may predispose to other arrhythmias.
This study will examine the incidence of discontinuation of AAD therapy and adverse events.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||5000 participants|
|Observational Model:||Ecologic or Community|
|Official Title:||Retrospective Record Linkage Study to Investigate the Incidence of Complications and Follow-up Associated With Anti-arrythmic Drug Therapy|
|Study Start Date :||March 2010|
|Estimated Primary Completion Date :||March 2011|
|Estimated Study Completion Date :||March 2011|
|Currently receiving antiarrythmic drugs|
- Adverse Event [ Time Frame: 10 years ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01082055
|Univeristy of Dundee|
|Dundee, United Kingdom, DD1 9SY|