Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial (POINT)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00991029 |
Recruitment Status
:
Active, not recruiting
First Posted
: October 7, 2009
Last Update Posted
: March 12, 2018
|
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- No Results Posted
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A transient ischemic attack (TIA) is a transient episode of neurological dysfunction caused by focal brain, spinal cord, or retinal ischemia, without acute infarction. An ischemic stroke is a cerebral infarction. In POINT, eligibility is limited to brain TIAs and to minor ischemic strokes (with an NIH Stroke Scale [NIHSS] score less than or equal to 3).
TIAs are common [25], and are often harbingers of disabling strokes. Approximately 250,000-350,000 TIAs are diagnosed each year in the US. Given median survival of more than 8 years [32], there are approximately 2.4 million TIA survivors. In a national survey, one in fifteen of those over 65 years old reported a history of TIA [33], which is equivalent to a prevalence of 2.3 million in older Americans. Based on the prevalence of undiagnosed transient neurological events, the true incidence of TIA may be twice as high as the rates of diagnosis [33]. Based on our review of the National Inpatient Sample for 1997-2003, there were an average of 200,000 hospital admissions for TIA each year, with annual charges climbing quickly in the period to $2.6 billion in 2003.
Composite endpoint of new ischemic vascular events: ischemic stroke, myocardial infarction or ischemic vascular death at 90 days.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Ischemic Attack, Transient | Drug: Clopidogrel Drug: placebo | Phase 3 |
Platelet-Oriented Inhibition in New TIA and minor ischemic stroke (POINT) Trial, is a prospective, randomized, double-blind, multicenter trial with the primary null hypothesis that, in patients with TIA or minor ischemic stroke treated with aspirin 50-325 mg/day, there is no difference in the event-free survival at 90 days in those treated with clopidogrel (600 mg loading dose then 75 mg/day) compared to placebo when subjects are randomized within 12 hours of time last known free of new ischemic symptoms.
Its primary objective is to determine whether clopidogrel 75 mg/day by mouth after a loading dose of 600 mg of clopidogrel is effective in preventing major ischemic vascular events (ischemic stroke, myocardial infarction, and ischemic vascular death) at 90 days when initiated within 12 hours of TIA or minor ischemic stroke onset in patients receiving aspirin 50-325 mg/day (with a dose of 150-200 mg daily for 5 days followed by 75-100 mg daily strongly recommended).
Patients over 18 years of age with high-risk TIA (defined as an ABCD2 score greater than or equal to 4) or minor ischemic stroke (with NIHSS less than or equal to 3) who can be treated within 12 hours of time last known free of new ischemic symptoms will be enrolled.
Subjects will be randomized 1:1 (clopidogrel: placebo), controlling for clinical center. A study participant's eligibility will be determined by site personnel prior to accessing the Randomization Module in the WebDCU™, a web-enabled clinical trials management system that was developed by the NETT Statistics and Data Management Center (SDMC) at Medical University of South Carolina (MUSC).Qualified users will access the Randomization Interface and complete a protocol-specific eligibility checklist. If the Randomization Interface finds the patient to be eligible based on the information provided, a randomization number and a confirmatory e-mail are generated.
Each subject is followed for 90 days from randomization; the trial will be completed in 7 years.
A total of 5,840 patients will be recruited. Recruitment will occur over 90 months, with a goal rate of 0.40 subjects/site/month for US sites, and a goal rate of 0.47 subjects/site/month for OUS sites. Current participating sites can be found at: http://www.pointtrial.org/node/18.
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 5840 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Investigator) |
Primary Purpose: | Treatment |
Official Title: | Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial |
Actual Study Start Date : | May 28, 2010 |
Estimated Primary Completion Date : | June 2018 |
Estimated Study Completion Date : | December 2018 |

Arm | Intervention/treatment |
---|---|
Active Comparator: clopidogrel
Patients assigned to clopidogrel in addition to aspirin
|
Drug: Clopidogrel
Loading dose of 600mg followed by 75 milligrams, oral, one tablet daily for 89 days
Other Name: Plavix
|
Placebo Comparator: placebo
Patients assigned to placebo in addition to aspirin
|
Drug: placebo
Loading dose of 8 tablets followed by one tablet daily for 89 days
|
- New ischemic vascular events (ischemic stroke, myocardial infarction, and ischemic vascular death [ Time Frame: 90 days ]
- secondary outcomes will be evaluated, separately including risk of ischemic stroke, intracranial hemorrhage, and major hemorrhage, and the composite of the primary outcome and major hemorrhage. [ Time Frame: 90 days ]

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
-
Neurological deficit (based on history or exam) attributed to focal brain ischemia and EITHER:
- High risk TIA: Complete resolution of the deficit at the time of randomization AND ABCD2 score of (greater than or equal to) 4 OR
- Minor ischemic stroke: residual deficit with NIHSS of (less than or equal to) 3 at the time of randomization
- Ability to randomize within 12 hours of time last known free of new ischemic symptoms.
- Head CT or MRI ruling out hemorrhage or other pathology, such as vascular malformation, tumor, or abscess, that could explain symptoms or contraindicate therapy.
- Ability to tolerate aspirin at a does of 50-325 mg/day.
Exclusion Criteria
- Age <18 years
- TIA symptoms limited to isolated numbness, isolated visual changes, or isolated dizziness/vertigo.
- In the judgment of the treating physician, a candidate for thrombolysis, endarterectomy or endovascular intervention, unless the subject declines both endarterectomy and endovascular intervention at the time of evaluation for eligibility.
- Receipt of any intravenous or intra-arterial thrombolysis within 1 week prior to index event.
- Gastrointestinal bleed or major surgery within 3 months prior to index event.
- History of nontraumatic intracranial hemorrhage.
- Clear indication for anticoagulation (e.g., warfarin, heparin) anticipated during the study period (atrial fibrillation, mechanical heart valve, deep venous thrombosis, pulmonary embolism, antiphospholipid antibody syndrome, hypercoagulable state).
- Qualifying ischemic event induced by angiography or surgery.
- Severe non-cardiovascular comorbidity with life expectancy <3 months.
-
Contraindication to clopidogrel or aspirin.
- Known allergy
- Severe renal (serum creatinine >2 mg/dL or 176.8umol/L) or hepatic insufficiency (prior or concurrent diagnosis, with International Normalized Ratio (INR)>1.5 or any resultant complication, such as variceal bleeding, encephalopathy, or icterus)
- Hemostatic disorder or systemic bleeding in the past 3 months
- Current thrombocytopenia (platelet count <100 x10^9/l) or neutropenia (<1 x10^9/l)
- History of drug-induced hematologic or hepatic abnormalities
- Anticipated requirement for long-term (>7 day) non-study antiplatelet drugs (eg, dipyridamole, clopidogrel, ticlopidine), or Non-steroidal Anti-inflammatory Drugs (NSAIDs) affecting platelet function (such as prior vascular stent or arthritis).
- Inability to swallow medications.
- At risk for pregnancy: premenopausal or post menopausal woman within 12 months of last menses without a negative pregnancy test or not committing to adequate birth control (e.g., oral contraceptive, two methods of barrier birth control, or abstinence).
- Unavailability for follow-up.
- Signed and dated informed consent not obtained from patient.
- Other neurological conditions that would complicate assessment of outcomes during follow-up.
- Ongoing treatment in another study of an investigational therapy that may potentially interact with study drug, or treatment in such a study within the last 7 days.
- Previously enrolled in the POINT study.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00991029

United States, Arizona | |
Chandler Regional Medical Center | |
Chandler, Arizona, United States, 85224 | |
Banner University Medical Center - Tucson Campus | |
Tucson, Arizona, United States, 85724 | |
United States, California | |
Mercy San Juan Medical Center | |
Carmichael, California, United States, 95608 | |
UCSD Health La Jolla | |
La Jolla, California, United States, 92037 | |
Loma Linda University Medical Center | |
Loma Linda, California, United States, 92354 | |
Long Beach Memorial Medical Center | |
Long Beach, California, United States, 90806 | |
Kaiser Permanente Los Angeles Medical Center | |
Los Angeles, California, United States, 90027 | |
Cedars-Sinai Medical Center | |
Los Angeles, California, United States, 90048 | |
Ronald Reagan UCLA Medical Center | |
Los Angeles, California, United States, 90095 | |
Desert Regional Medical Center | |
Palm Springs, California, United States, 92262 | |
Huntington Memorial Hospital | |
Pasadena, California, United States, 91105 | |
UC Davis Medical Center | |
Sacramento, California, United States, 95817 | |
Mercy General Hospital | |
Sacramento, California, United States, 95819 | |
Scripps Mercy Hospital San Diego | |
San Diego, California, United States, 92103 | |
UCSD Medical Center - Hillcrest Hospital | |
San Diego, California, United States, 92103 | |
San Francisco General Hospital | |
San Francisco, California, United States, 94110 | |
UCSF Medical Center | |
San Francisco, California, United States, 94143 | |
Stanford University Medical Center | |
Stanford, California, United States, 94305 | |
Los Robles Hospital and Medical Center | |
Thousand Oaks, California, United States, 91360 | |
United States, Colorado | |
University of Colorado Hospital | |
Aurora, Colorado, United States, 80045 | |
Swedish Medical Center | |
Englewood, Colorado, United States, 80113 | |
St. Anthony Hospital | |
Lakewood, Colorado, United States, 80228 | |
United States, Connecticut | |
Yale-New Haven Hospital | |
New Haven, Connecticut, United States, 06510 | |
United States, Delaware | |
Christiana Hospital | |
Newark, Delaware, United States, 19713 | |
United States, District of Columbia | |
George Washington University Hospital | |
Washington, District of Columbia, United States, 20037 | |
United States, Florida | |
UF Health Shands Hospital | |
Gainesville, Florida, United States, 32608 | |
University of Florida | |
Jacksonville, Florida, United States, 32209 | |
Sarasota Memorial Hospital | |
Sarasota, Florida, United States, 34239 | |
United States, Georgia | |
Grady Memorial Hospital | |
Atlanta, Georgia, United States, 30303 | |
Emory University Hospital Midtown | |
Atlanta, Georgia, United States, 30308 | |
Emory University Hospital | |
Atlanta, Georgia, United States, 30322 | |
Augusta University Medical Center | |
Augusta, Georgia, United States, 30912 | |
United States, Hawaii | |
the Queen's Medical Center | |
Honolulu, Hawaii, United States, 96813 | |
United States, Illinois | |
Northwestern Memorial Hospital | |
Chicago, Illinois, United States, 60611 | |
Rush University Medical Center | |
Chicago, Illinois, United States, 60612 | |
University of Illinois Hospital | |
Chicago, Illinois, United States, 60612 | |
Alexian Brothers Medical Center | |
Elk Grove Village, Illinois, United States, 60007 | |
Evanston Hospital | |
Evanston, Illinois, United States, 60201 | |
NorthShore Glenbrook Hospital | |
Glenview, Illinois, United States, 60026 | |
Presence Saint Joseph Medical Center | |
Joliet, Illinois, United States, 60435 | |
Loyola University Medical Center | |
Maywood, Illinois, United States, 60153 | |
Southern Illinois University Memorial Medical Center | |
Springfield, Illinois, United States, 62781 | |
United States, Iowa | |
University of Iowa Hospitals and Clinics | |
Iowa City, Iowa, United States, 52242 | |
United States, Kansas | |
University of Kansas Hospital | |
Kansas City, Kansas, United States, 66160 | |
United States, Kentucky | |
St. Elizabeth Medical Center South | |
Edgewood, Kentucky, United States, 41017 | |
St. Elizabeth Hospital | |
Florence, Kentucky, United States, 41042 | |
St. Elizabeth Hospital Fort Thomas | |
Fort Thomas, Kentucky, United States, 41075 | |
University of Kentucky Hospital | |
Lexington, Kentucky, United States, 40536 | |
University of Louisville Hospital | |
Louisville, Kentucky, United States, 40202 | |
United States, Maryland | |
University of Maryland Medical Center | |
Baltimore, Maryland, United States, 21201 | |
Frederick Memorial Hospital | |
Frederick, Maryland, United States, 21701 | |
United States, Massachusetts | |
Massachusetts General Hospital | |
Boston, Massachusetts, United States, 02114 | |
Brigham and Women's Hospital | |
Boston, Massachusetts, United States, 02115 | |
Boston Medical Center | |
Boston, Massachusetts, United States, 02118 | |
Beth Israel Deaconess Medical Center | |
Boston, Massachusetts, United States, 02215 | |
UMASS Memorial Medical Center | |
Worcester, Massachusetts, United States, 01655 | |
United States, Michigan | |
Detroit Receiving Hospital | |
Detroit, Michigan, United States, 48201 | |
Harper University Hospital | |
Detroit, Michigan, United States, 48201 | |
Henry Ford Hospital | |
Detroit, Michigan, United States, 48202 | |
Sinai-Grace Hospital | |
Detroit, Michigan, United States, 48235 | |
St. John Hospital and Medical Center | |
Detroit, Michigan, United States, 48236 | |
Mercy Health Saint Mary's | |
Grand Rapids, Michigan, United States, 49503 | |
William Beaumont Hospital | |
Royal Oak, Michigan, United States, 48073 | |
William Beaumont Hospital - Troy | |
Troy, Michigan, United States, 48085 | |
Henry Ford West Bloomfield Hospital | |
West Bloomfield, Michigan, United States, 48322 | |
United States, Minnesota | |
Fairview Southdale Hospital | |
Edina, Minnesota, United States, 55435 | |
Abbott Northwestern Hospital | |
Minneapolis, Minnesota, United States, 55407 | |
Hennepin County Medical Center | |
Minneapolis, Minnesota, United States, 55415 | |
University of Minnesota Medical Center Hospital | |
Minneapolis, Minnesota, United States, 55454 | |
Mayo Clinic Saint Mary's Campus | |
Rochester, Minnesota, United States, 55902 | |
United Hospital | |
Saint Paul, Minnesota, United States, 55102 | |
United States, Missouri | |
Barnes Jewish Hospital | |
Saint Louis, Missouri, United States, 63110 | |
Mercy Hospital | |
Saint Louis, Missouri, United States, 63141 | |
Mercy Hospital | |
Springfield, Missouri, United States, 65804 | |
United States, Montana | |
Benefis Hospitals Inc | |
Great Falls, Montana, United States, 59405 | |
Great Falls Clinic Hospital, Great Falls | |
Great Falls, Montana, United States, 59405 | |
United States, New Hampshire | |
Dartmouth-Hitchcock Medical Center | |
Lebanon, New Hampshire, United States, 03766 | |
United States, New Jersey | |
Cooper University Hospital | |
Camden, New Jersey, United States, 08103 | |
JFK Medical Center | |
Edison, New Jersey, United States, 08820 | |
Hackensack University Medical Center | |
Hackensack, New Jersey, United States, 07601 | |
Jersey Shore University Medical Center | |
Neptune, New Jersey, United States, 07753 | |
Robert Wood Johnson University Hospital | |
New Brunswick, New Jersey, United States, 08901 | |
United States, New York | |
Lincoln Medical and Mental Health Center | |
Bronx, New York, United States, 10451 | |
Kings County Hospital Center | |
Brooklyn, New York, United States, 11203 | |
SUNY Downstate Medical Center | |
Brooklyn, New York, United States, 11203 | |
Maimonides Medical Center | |
Brooklyn, New York, United States, 11219 | |
Buffalo General Medical Center | |
Buffalo, New York, United States, 14203 | |
New York Presbyterian / Columbia University Medical Center | |
New York, New York, United States, 10032 | |
NYP Weill Cornell Medical Center | |
New York, New York, United States, 10065 | |
Rochester General Hospital | |
Rochester, New York, United States, 14621 | |
Strong Memorial Hospital | |
Rochester, New York, United States, 14642 | |
Stony Brook University Hospital | |
Stony Brook, New York, United States, 11794 | |
SUNY Upstate Medical University | |
Syracuse, New York, United States, 13210 | |
United States, North Carolina | |
Guilford Neurologic Associates | |
Greensboro, North Carolina, United States, 27405 | |
Wake Forest Baptist Medical Center | |
Winston-Salem, North Carolina, United States, 27157 | |
United States, Ohio | |
Summa Akron City Hospital | |
Akron, Ohio, United States, 44304 | |
Mercy Health West Hospital | |
Cincinnati, Ohio, United States, 45211 | |
Christ Hospital | |
Cincinnati, Ohio, United States, 45219 | |
University of Cincinnati Medical Center | |
Cincinnati, Ohio, United States, 45219 | |
Good Samaritan Hospital | |
Cincinnati, Ohio, United States, 45220 | |
Jewish Hospital | |
Cincinnati, Ohio, United States, 45236 | |
Bethesda North Hospital | |
Cincinnati, Ohio, United States, 45242 | |
MetroHealth Medical Center | |
Cleveland, Ohio, United States, 44109 | |
Cleveland Clinic | |
Cleveland, Ohio, United States, 44195 | |
OSU Wexner Medical Center | |
Columbus, Ohio, United States, 43210 | |
Mount Carmel East Hospital | |
Columbus, Ohio, United States, 43213 | |
Miami Valley Hospital | |
Dayton, Ohio, United States, 45409 | |
University of Toledo Medical Center | |
Toledo, Ohio, United States, 43614 | |
United States, Oregon | |
Providence Portland Medical Center | |
Portland, Oregon, United States, 97213 | |
Providence St. Vincent Medical Center | |
Portland, Oregon, United States, 97225 | |
Oregon Health and Science University Hospital | |
Portland, Oregon, United States, 97239 | |
Portland VA Medical Center | |
Portland, Oregon, United States, 97239 | |
United States, Pennsylvania | |
Abington Memorial Hospital | |
Abington, Pennsylvania, United States, 19001 | |
Lehigh Valley Hospital | |
Allentown, Pennsylvania, United States, 18103 | |
Pennsylvania State Hershey Medical Center | |
Hershey, Pennsylvania, United States, 17033 | |
Hahnemann University Hospital | |
Philadelphia, Pennsylvania, United States, 19102 | |
Hospital of the University of Pennsylvania | |
Philadelphia, Pennsylvania, United States, 19104 | |
Penn Presbyterian Medical Center | |
Philadelphia, Pennsylvania, United States, 19104 | |
Pennsylvania Hospital | |
Philadelphia, Pennsylvania, United States, 19107 | |
Thomas Jefferson University Hospital | |
Philadelphia, Pennsylvania, United States, 19107 | |
Temple University Hospital | |
Philadelphia, Pennsylvania, United States, 19140 | |
UPMC Presbyterian Hospital | |
Pittsburgh, Pennsylvania, United States, 15213 | |
UPMC Shadyside Hospital | |
Pittsburgh, Pennsylvania, United States, 15232 | |
WellSpan York Hospital | |
York, Pennsylvania, United States, 17403 | |
United States, Rhode Island | |
Rhode Island Hospital | |
Providence, Rhode Island, United States, 02903 | |
United States, South Carolina | |
Medical University of South Carolina University Hospital | |
Charleston, South Carolina, United States, 29425 | |
Palmetto Health Richland | |
Columbia, South Carolina, United States, 29203 | |
United States, Tennessee | |
Vanderbilt University Hospital | |
Nashville, Tennessee, United States, 37323 | |
United States, Texas | |
University Medical Center Brackenridge | |
Austin, Texas, United States, 78701 | |
Seton Medical Center | |
Austin, Texas, United States, 78705 | |
Texas Health Presbyterian Hospital - Dallas | |
Dallas, Texas, United States, 75231 | |
Valley Baptist Medical Center - Harlingen | |
Harlingen, Texas, United States, 78550 | |
Ben Taub General Hospital | |
Houston, Texas, United States, 77030 | |
Houston Methodist Hospital | |
Houston, Texas, United States, 77030 | |
Memorial Hermann Texas Medical Center | |
Houston, Texas, United States, 77030 | |
University of Texas Health Science Center San Antonio | |
San Antonio, Texas, United States, 78229 | |
United States, Virginia | |
UVA Medical Center | |
Charlottesville, Virginia, United States, 22908 | |
Bon Secours St. Francis Medical Center | |
Richmond, Virginia, United States, 23114 | |
Bon Secours St. Mary's Hospital | |
Richmond, Virginia, United States, 23226 | |
Henrico Doctors' Hospital - Forest Campus | |
Richmond, Virginia, United States, 23229 | |
Henrico Doctors' Hospital - Parham Campus | |
Richmond, Virginia, United States, 23294 | |
United States, Washington | |
Harborview Medical Center | |
Seattle, Washington, United States, 98104 | |
University of Washington Medical Center | |
Seattle, Washington, United States, 98195 | |
United States, West Virginia | |
WVU Healthcare Ruby Memorial Hospital | |
Morgantown, West Virginia, United States, 26505 | |
United States, Wisconsin | |
Columbia St. Mary's Hospital | |
Milwaukee, Wisconsin, United States, 53211 | |
Aurora St. Luke's Medical Center | |
Milwaukee, Wisconsin, United States, 53215 | |
Froedtert Memorial Lutheran Hospital | |
Milwaukee, Wisconsin, United States, 53226 | |
Australia, New South Wales | |
Gosford Hospital | |
Gosford, New South Wales, Australia | |
John Hunter Hospital | |
New Lambton, New South Wales, Australia | |
Australia, South Australia | |
Royal Adelaide Hospital | |
Adelaide, South Australia, Australia | |
Australia, Victoria | |
Box Hill Hospital | |
Box Hill, Victoria, Australia | |
Monash Medical Centre | |
Clayton, Victoria, Australia | |
The Northern Hospital | |
Epping, Victoria, Australia | |
Footscray Hospital | |
Footscray, Victoria, Australia | |
Austin Hospital | |
Heidelberg, Victoria, Australia | |
Royal Melbourne Hospital | |
Parkville, Victoria, Australia | |
Canada, Alberta | |
University of Calgary - Foothills Campus | |
Calgary, Alberta, Canada | |
Grey Nuns Hospital | |
Edmonton, Alberta, Canada | |
University of Alberta Hospital | |
Edmonton, Alberta, Canada | |
Canada, British Columbia | |
Vancouver General Hospital | |
Vancouver, British Columbia, Canada | |
Canada, Ontario | |
London Health Sciences Center | |
London, Ontario, Canada | |
Canada, Quebec | |
Charles LeMoyne Hospital | |
Greenfield Park, Quebec, Canada | |
Montreal General Hospital | |
Montreal, Quebec, Canada | |
Notre-Dame Hospital | |
Montreal, Quebec, Canada | |
Canada | |
Enfant-Jesus Hospital | |
Quebec, Canada | |
Finland | |
Helsinki University Central Hospital | |
Helsinki, Finland | |
Turku University Hospital | |
Turku, Finland | |
France | |
Fleyriat Hospital | |
Bourg-en-Bresse, France | |
Pierre Wetheimer Hospital | |
Bron, France | |
Adolphe de Rothschild Ophthalmologic Foundation | |
Paris, France | |
Bichat-Claude Bernard Hospital | |
Paris, France | |
Pitie-Salpetriere Hospital | |
Paris, France | |
Foch Hospital | |
Suresnes, France | |
Germany | |
University Hospital of Ulm | |
Ulm, Baden-Württemberg, Germany, 89081 | |
Neurological Clinic Bad Neustadt | |
Bad Neustadt an der Saale, Germany | |
Vivantes Hospital Neukolln | |
Berlin, Germany | |
Central Bremen Hospital | |
Bremen, Germany | |
University Hospital Essen | |
Essen, Germany | |
University Hospital Frankfurt | |
Frankfurt, Germany | |
University Medical Center Hamburg | |
Hamburg, Germany | |
Hannover Medical School | |
Hannover, Germany | |
University Hospital Heidelberg | |
Heidelberg, Germany | |
University Hospital Schleswig-Holstein Kiel Campus | |
Kiel, Germany | |
University Medical Center Leipzig | |
Leipzig, Germany | |
University Hospital Munster | |
Munster, Germany | |
Mexico | |
Mexican Association for Clinical Research | |
Pachuca, Hidalgo, Mexico | |
Central Hospital Dr. Ignacio Morones Prieto | |
San Luis Potosí, San Luis Potosi, Mexico, 78240 | |
Culiacan General Hospital | |
Culiacan, Sinaloa, Mexico | |
Neurosciences Clinical Trials | |
Culiacan, Sinaloa, Mexico | |
ABC Medical Center Santa Fe | |
Mexico City, Mexico | |
New Zealand | |
Auckland City Hospital | |
Auckland, New Zealand | |
Spain | |
Hospital del Mar | |
Barcelona, Spain | |
Santa Creu and Sant Pau Hospital | |
Barcelona, Spain | |
Vall d'Hebron Hospital | |
Barcelona, Spain | |
Basurto Hospital | |
Bilbao, Spain | |
Burgos University Hospital | |
Burgos, Spain | |
Hospital Donostia | |
Donostia, Spain | |
Girona University HOspital | |
Girona, Spain | |
La Fe University Hospital | |
Valencia, Spain | |
Miguel Servet Hospital | |
Zaragoza, Spain | |
United Kingdom | |
Addenbrooke's Hospital | |
Cambridge, United Kingdom | |
Queen Elizabeth University Hospital | |
Glasgow, United Kingdom | |
Northwick Park Hospital | |
Harrow, United Kingdom | |
The Royal London Hospital | |
London, United Kingdom | |
University College Hospital | |
London, United Kingdom | |
Luton and Dunstable University Hospital | |
Luton, United Kingdom | |
John Radcliffe Hospital | |
Oxford, United Kingdom | |
Royal United Hospital - Bath | |
Somerset, United Kingdom | |
Southampton General Hospital | |
Southampton, United Kingdom | |
Royal Stoke University Hospital | |
Stoke-on-Trent, United Kingdom |
Principal Investigator: | S. Claiborne Johnston, MD, PhD | University of Texas, Austin | |
Principal Investigator: | J. Donald Easton, MD | University of California, San Francisco | |
Principal Investigator: | Anthony S. Kim, MD, MAS | University of California, San Francisco |
Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | University of California, San Francisco |
ClinicalTrials.gov Identifier: | NCT00991029 History of Changes |
Other Study ID Numbers: |
1U01S062835-01A1 |
First Posted: | October 7, 2009 Key Record Dates |
Last Update Posted: | March 12, 2018 |
Last Verified: | March 2018 |
Studies a U.S. FDA-regulated Drug Product: | Yes | |
Studies a U.S. FDA-regulated Device Product: | No |
Keywords provided by University of California, San Francisco:
Transient Ischemic Attack TIA minor stroke |
Additional relevant MeSH terms:
Ischemia Ischemic Attack, Transient Pathologic Processes Brain Ischemia Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases |
Clopidogrel Platelet Aggregation Inhibitors Purinergic P2Y Receptor Antagonists Purinergic P2 Receptor Antagonists Purinergic Antagonists Purinergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs |