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Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

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ClinicalTrials.gov Identifier: NCT00978640
Recruitment Status : Unknown
Verified June 2012 by University of Aarhus.
Recruitment status was:  Active, not recruiting
First Posted : September 17, 2009
Last Update Posted : June 20, 2012
Sponsor:
Information provided by (Responsible Party):
University of Aarhus

Brief Summary:

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).

Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.

In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.


Condition or disease Intervention/treatment Phase
Healthy Other: fast and exercise Other: exercise Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 8 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise
Study Start Date : September 2009
Estimated Primary Completion Date : June 2012
Estimated Study Completion Date : June 2012

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: fasting and exercise
36 h fast and 1 h ergometer cycling 50% VO2max
Other: fast and exercise
fasting 36 h and exercise 1 h 50% VO2max

Experimental: exercise
1 h ergometer cycling 50% VO2max
Other: exercise
exercise 1 h 50% VO2max




Primary Outcome Measures :
  1. Sirt1 activity [ Time Frame: 60 min ]

Secondary Outcome Measures :
  1. secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover. [ Time Frame: 4 h ]


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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy men
  • Body mass index (BMI) 20-26
  • age 18-45 years

Exclusion Criteria:

  • any kind of disease
  • any use of medicine

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00978640


Locations
Denmark
mikkel Holm Vendelbo
Århus, Jylland, Denmark, 8000
Sponsors and Collaborators
University of Aarhus

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT00978640     History of Changes
Other Study ID Numbers: 07.09.2009
First Posted: September 17, 2009    Key Record Dates
Last Update Posted: June 20, 2012
Last Verified: June 2012

Keywords provided by University of Aarhus:
Sirt1 activity