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Correlation of Genetic Polymorphism and Livedo Vasculitis

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00975871
First Posted: September 14, 2009
Last Update Posted: October 23, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Taiwan University Hospital
  Purpose
Livedo vasculitis is disease with recurrent courses of painful foot or ankle ulcerations, followed by healed white scars. The actual mechanism of its pathophysiology is not yet clear. It has been reported to be associated with some gene mutations, for example, factor V Leiden gene. This study is aimed to find the possible relation of these gene mutations in Taiwanese patients.

Condition
Livedo Vasculitis Livedoid Vasculitis Livedoid Vasculopathy Genetic Pleomorphism Leiden Mutation

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Correlation of Genetic Polymorphism and Livedo Vasculitis

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   Samples With DNA
Buccal mucosa cotton tip swab

Enrollment: 50
Study Start Date: October 2007
Study Completion Date: April 2009
Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
Detailed Description:
Livedo vasculitis is a chronic, recurrent painful ulcerations on the ankles and feet. This chronic disease is characterized by healed white, atrophic scars named atrophie blanche. The histopathological exam on the lesion site reveals fibrin deposition within the vessel walls. It has been reported to be related to factor V Leiden mutation (heterozygous) (22.2%), prothrombin G20210A gene mutation (8.3%), PAI promotor 4G/4G genotype and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in about total 30% livedo vasculitis patients. This study is trying to find the correlation between Taiwanese patients and these four genes.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
General population
Criteria

Inclusion Criteria:

  • Clinical diagnosis of livedo vasculitis

Exclusion Criteria:

  • No special exclusion criteria
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00975871


Locations
Taiwan
National Taiwan University Hospital
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Tsen-Fang Tsai, MD National Taiwan University Hospital
  More Information

Responsible Party: Tsen-Fang Tsai/M.D, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00975871     History of Changes
Other Study ID Numbers: 0961172000
First Submitted: September 11, 2009
First Posted: September 14, 2009
Last Update Posted: October 23, 2009
Last Verified: October 2009

Keywords provided by National Taiwan University Hospital:
Livedo vasculitis
Genetic pleomorphism

Additional relevant MeSH terms:
Vasculitis
Vascular Diseases
Cardiovascular Diseases