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Correlation of Genetic Polymorphism and Livedo Vasculitis

This study has been completed.
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 11, 2009
Last updated: October 21, 2009
Last verified: October 2009
Livedo vasculitis is disease with recurrent courses of painful foot or ankle ulcerations, followed by healed white scars. The actual mechanism of its pathophysiology is not yet clear. It has been reported to be associated with some gene mutations, for example, factor V Leiden gene. This study is aimed to find the possible relation of these gene mutations in Taiwanese patients.

Livedo Vasculitis
Livedoid Vasculitis
Livedoid Vasculopathy
Genetic Pleomorphism
Leiden Mutation

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Correlation of Genetic Polymorphism and Livedo Vasculitis

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   Samples With DNA
Buccal mucosa cotton tip swab

Enrollment: 50
Study Start Date: October 2007
Study Completion Date: April 2009
Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
Detailed Description:
Livedo vasculitis is a chronic, recurrent painful ulcerations on the ankles and feet. This chronic disease is characterized by healed white, atrophic scars named atrophie blanche. The histopathological exam on the lesion site reveals fibrin deposition within the vessel walls. It has been reported to be related to factor V Leiden mutation (heterozygous) (22.2%), prothrombin G20210A gene mutation (8.3%), PAI promotor 4G/4G genotype and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in about total 30% livedo vasculitis patients. This study is trying to find the correlation between Taiwanese patients and these four genes.

Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
General population

Inclusion Criteria:

  • Clinical diagnosis of livedo vasculitis

Exclusion Criteria:

  • No special exclusion criteria
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Please refer to this study by its identifier: NCT00975871

National Taiwan University Hospital
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Tsen-Fang Tsai, MD National Taiwan University Hospital
  More Information

Responsible Party: Tsen-Fang Tsai/M.D, National Taiwan University Hospital Identifier: NCT00975871     History of Changes
Other Study ID Numbers: 0961172000
Study First Received: September 11, 2009
Last Updated: October 21, 2009

Keywords provided by National Taiwan University Hospital:
Livedo vasculitis
Genetic pleomorphism

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases processed this record on May 24, 2017