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The Comparison of Oxidative Stress Between Inhalation Anesthetics

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ClinicalTrials.gov Identifier: NCT00965445
Recruitment Status : Completed
First Posted : August 25, 2009
Last Update Posted : August 26, 2009
Sponsor:
Information provided by:
Chang Gung Memorial Hospital

Study Description
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Brief Summary:
Oxidative stress is an unavoidable event during cardiac surgery. Isoprostanes have been demonstrated to be a reliable biomarker for the evaluation of oxidative stress in vivo.The aims of this study are(1)to develop an accurate liquid chromatography-tandem mass spectrometry methods for the detection of urinary isoprostane isomers in samples collected from healthy volunteers(for method quality control) and patients receiving a cardiac surgery (2)to investigate the change of isoprostanes after cardiopulmonary bypass(CPB) (3)to investigate the effect of different anesthetics on isoprostanes.

Condition or disease
Oxidative Stress Cardiac Surgery

Detailed Description:

Enhanced production of oxygen free radicals can lead to the generation of oxidative stress, which is harmful to human tissue and organs. Reactive oxygen species are released abruptly during some surgical procedures, and they are the major causes of ischemia-reperfusion injuries.Isoprostanes have been demonstrated to be a reliable biomarker for the evaluation of oxidative stress in vivo. Therefore, accurately monitoring and avoiding the occurrence of oxidative stress during surgery is an important clinical issue.

Isoprostanes are a series of prostaglandin-like compounds produced by non-enzymatic peroxidation of arachidonic acid.The aims of this study are(1)to develop an accurate liquid chromatography-tandem mass spectrometry methods for the detection of urinary isoprostane isomers in samples collected from patients receiving a cardiac surgery (2)to investigate the change of isoprostanes after cardiopulmonary bypass (3)to investigate the effect of different anesthetics on isoprostanes during surgery.

Study Design
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Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: The Comparison of Oxidative Stress Between Inhalation Anesthetics
Study Start Date : March 2007
Actual Primary Completion Date : December 2007
Actual Study Completion Date : December 2007
Groups and Cohorts
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Group/Cohort
cardiac surgery with CPB


Outcome Measures
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Primary Outcome Measures :
  1. isoprostanes isomer as marker of oxidative stress [ Time Frame: one day ]

Biospecimen Retention:   Samples Without DNA
thirty milliliters of urine was collected from urine bag of patients at the following times: baseline before anesthesia, 30 minutes before cardiopulmonary bypass, during cardiopulmonary bypass, after the end of cardiopulmonary bypass.

Eligibility Criteria
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Ages Eligible for Study:   25 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
patients receiving cardiac valve surgery in Taipei Change Gung Memorial Hospital will be invited to participate this study
Criteria

Inclusion Criteria:

  • patients receiving cardiac valve surgery in ASA II-III physical status

Exclusion Criteria:

  • trauma, infection, low ejection fraction (less than 25%), liver cirrhosis, or acute renal failure, and emergency surgery
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00965445


Locations
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Taiwan
Dept. of Anesthesiology, Chang Gung Memorial Hospital
Taipei, Taiwan, 105
Sponsors and Collaborators
Chang Gung Memorial Hospital
Investigators
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Principal Investigator: Yun-Hui Teng, MD Chang Gung Memorial Hospital
More Information
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Responsible Party: Chang Gung Memorial Hospital
ClinicalTrials.gov Identifier: NCT00965445    
Other Study ID Numbers: CGMH-IRB-96-0019B
CGMH-IRB-96-0019B
First Posted: August 25, 2009    Key Record Dates
Last Update Posted: August 26, 2009
Last Verified: August 2009
Keywords provided by Chang Gung Memorial Hospital:
isoprostanes
mass spectrometry
Additional relevant MeSH terms:
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Respiratory Aspiration
Respiration Disorders
Respiratory Tract Diseases
Pathologic Processes