Trial record 1 of 1 for:    RTOG 0815
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Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
National Cancer Institute (NCI)
NRG Oncology
Information provided by (Responsible Party):
Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier:
NCT00936390
First received: July 8, 2009
Last updated: March 8, 2016
Last verified: March 2016
  Purpose

RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors. Androgens can cause the growth of prostate cancer cells. Androgen-deprivation therapy may lessen the amount of androgens made by the body. It is not yet known whether radiation therapy is more effective with or without androgen-deprivation therapy in treating patients with prostate cancer.

PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with androgen-deprivation therapy in treating patients with prostate cancer.


Condition Intervention Phase
Prostate Cancer
Drug: bicalutamide
Drug: buserelin
Drug: flutamide
Drug: goserelin acetate
Drug: leuprolide acetate
Drug: triptorelin
Radiation: 3-dimensional conformal radiation therapy
Radiation: intensity-modulated radiation therapy
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer

Resource links provided by NLM:


Further study details as provided by Radiation Therapy Oncology Group:

Primary Outcome Measures:
  • Overall survival (OS) [ Time Frame: From the date of randomization to the date of death due to any cause. ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Biochemical failure according to the Phoenix (nadir + 2) definition [ Time Frame: From the date of randomization to the date of first documented rise in PSA of 2 ng/ml above the post treatment nadir value. ] [ Designated as safety issue: No ]
  • Local recurrence [ Time Frame: From the date of randomization to the date of first palpable progression or pathologic confirmation of local progression or to the date of first biochemical failure (nadir +2ng/ml) once the possibility of distant metastasis is ruled out. ] [ Designated as safety issue: No ]
  • Regional recurrence [ Time Frame: From the date of randomization to the date of first documented progression in pelvic lymph nodes or the date of first documented biochemical failure (BCF) if the CT of the pelvis was prompted by a BCF. ] [ Designated as safety issue: No ]
  • Distant metastasis [ Time Frame: From the date of randomization to the date of first documented metastatic disease by any measure or to the date of first documented biochemical failure if diagnostic imaging is prompted by BCF. ] [ Designated as safety issue: No ]
  • Prostate cancer-specific mortality [ Time Frame: From the date of randomization to the date of death due to prostate cancer/complication of treatment. ] [ Designated as safety issue: No ]
  • Non-prostate cancer-specific mortality [ Time Frame: From the date of randomization to the date of death without the evidence of prostate cancer/complication of treatment. ] [ Designated as safety issue: No ]
  • Rate of salvage androgen-deprivation therapy [ Time Frame: From the end of treatment to the date of first administration of ADT. ] [ Designated as safety issue: No ]
  • Rates of OS for patients treated with the 3 different radiotherapy modalities in each arm [ Time Frame: From the date of randomization to the date of death due to any cause. ] [ Designated as safety issue: No ]
  • Incidence of "acute" adverse events as assessed by NCI Common Toxicity Criteria for Adverse Effects (CTCAE) v. 4.0 [ Time Frame: From the start of radiation therapy (RT) to first occurrence of worse severity of adverse event within 30 days after the completion of RT. ] [ Designated as safety issue: Yes ]
  • Time to "late" grade 3+ adverse events as assessed by NCI CTCAE v. 4.0 [ Time Frame: From the date of completion of RT to the date of first grade 3 or above adverse event occurring 30 days after the completion of RT. ] [ Designated as safety issue: Yes ]
  • Freedom from Failure [ Time Frame: From date of randomization to the date of first event of biochemical failure or local recurrence or regional reccurrence or distant metastasis. ] [ Designated as safety issue: No ]
  • Comparison of prostate cancer-specific health related quality of life (HRQOL) change as measured by EPIC [ Time Frame: From date of randomization to the following times: last week of RT, 6 months, 1 year and 5 years post RT. ] [ Designated as safety issue: No ]
  • Comparison of fatigue status as measured by the Patient Reported Outcome Measurement Information System (PROMIS) fatigue domain [ Time Frame: From date of randomization to the following times: last week of RT, 6 months, 1 year and 5 years post RT. ] [ Designated as safety issue: No ]
  • Assessment and comparison of Quality Adjusted Life Years (QALYs) [ Time Frame: From date of randomization to the following times: last week of RT, 6 months, 1 year and 5 years post RT. ] [ Designated as safety issue: No ]
  • Correlation between the fatigue PROMIS score change and plasma cytokine change [ Time Frame: From date of randomization to 3 weeks from start of RT. ] [ Designated as safety issue: No ]

Enrollment: 1538
Study Start Date: September 2009
Estimated Primary Completion Date: December 2020 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Arm I
Patients undergo external-beam radiation therapy (EBRT) once daily on days 1-5. Some patients instead receive EBRT with high-dose rate or low-dose rate brachytherapy implant.
Radiation: 3-dimensional conformal radiation therapy
Given as external-beam radiation therapy
Radiation: intensity-modulated radiation therapy
Given as external-beam radiation therapy
Experimental: Arm II
Patients receive androgen-deprivation therapy comprising luteinizing-hormone releasing-hormone (LHRH) agonist (leuprolide, goserelin, buserelin, or triptorelin) subcutaneously or as an injection every 1 to 3 months AND an oral antiandrogen therapy (flutamide 3 times daily or bicalutamide once daily) for 6 months. Beginning 8 weeks after the first LHRH injection, patients undergo radiotherapy as in arm I.
Drug: bicalutamide
Given orally
Drug: buserelin
Given subcutaneously or as an injection
Drug: flutamide
Given orally
Drug: goserelin acetate
Given subcutaneously or as an injection
Drug: leuprolide acetate
Given subcutaneously or as an injection
Drug: triptorelin
Given subcutaneously or as an injection
Radiation: 3-dimensional conformal radiation therapy
Given as external-beam radiation therapy
Radiation: intensity-modulated radiation therapy
Given as external-beam radiation therapy

Detailed Description:

OBJECTIVES:

Primary

  • Demonstrate an overall survival (OS) advantage in patients with intermediate-risk prostate cancer treated with dose-escalated radiotherapy (RT) with versus without short-term androgen-deprivation therapy (ADT).

Secondary

  • Determine whether the addition of ADT to dose-escalated RT versus RT alone improves clinical failures, biochemical failure by the "nadir +2", freedom from failure, rate of salvage ADT, and prostate cancer-specific mortality in these patients.
  • Estimate the magnitude of benefit of ADT with respect to OS in patients treated with different RT modalities (i.e., external-beam radiation therapy alone vs low-dose rate brachytherapy boost vs high-dose rate brachytherapy boost).
  • Compare acute and late treatment adverse events of these regimens and correlate these events with the presence or absence of pre-existing comorbidity as documented by the Adult Comorbidity Evaluation 27 assessment.

OUTLINE: This is a multicenter, dose-escalation study of radiotherapy. Patients are stratified according to number of risk factors (1 vs 2-3), comorbidity (ACE-27 grade ≥ 2 vs < 2), and radiotherapy (RT) modality (dose-escalated external-beam RT [EBRT] vs EBRT and low-dose rate brachytherapy boost vs EBRT and high-dose rate brachytherapy boost). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients undergo EBRT* once daily on days 1-5 for about 9 weeks (44 treatments). Some patients instead receive EBRT with high-dose rate or low-dose rate brachytherapy implant on days 1-5 for about 5 weeks (25 treatments). NOTE: *Type of RT is at discretion of treating physician and may include either 3D-conformal RT or intensity-modulated RT.
  • Arm II: Patients receive androgen-deprivation therapy comprising luteinizing-hormone releasing-hormone (LHRH) agonist (leuprolide, goserelin, buserelin, or triptorelin) subcutaneously or as an injection every 1 to 3 months AND an oral antiandrogen therapy (flutamide 3 times daily or bicalutamide once daily) for 6 months. Beginning 8 weeks after the first LHRH injection, patients undergo radiotherapy as in arm I.

After completion of study therapy, patients are followed up periodically.

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed adenocarcinoma of the prostate diagnosed within the past 180 days and at intermediate-risk for recurrence by meeting 1 or more of the following criteria:

    • Gleason score = 7
    • Prostate Specific Antigen (PSA) > 10 and ≤ 20 ng/mL

      • Baseline serum PSA value performed within 60 days with an FDA-approved assay (e.g., Abbott, Hybritech)
      • Baseline PSA must not be obtained during any of the following time frames:10-day period after prostate biopsy, after initiation of androgen-deprivation therapy, or within the past 30 days after discontinuation of finasteride (90 days for dutasteride)
    • Clinical stage T2b or T2c disease
    • Patients previously diagnosed with low-risk (Gleason score < 6, clinical stage < T2a, and PSA < 10 ng/mL) prostate cancer undergoing active surveillance who are re-biopsied and found to have intermediate-risk disease according to the protocol criteria are eligible for enrollment within 6 months of the repeat biopsy procedure
  • Patients with Gleason Score ≥ 8, PSA > 20 ng/mL, OR clinical stage ≥ T3 are ineligible for this trial

    • If findings of extracapsular extension or seminal vesicle invasion are noted on prostate MRI, this study, if used, will not render patients ineligible for accrual to this protocol
    • Primary tumor staging for eligibility purposes is to be based on palpable or core biopsy evidence only with respect to extracapsular extension or seminal vesicle involvement
  • No patients with all 3 intermediate-risk factors who also have ≥ 50% of the number of their biopsy cores positive for cancer

    • The percentage of biopsy cores involved will only be considered with respect to eligibility for those patients with all 3 of the above risk factors (i.e., patients with one or two of the above risk factors are eligible irrespective of the percentage of biopsy cores involved)
  • Clinically negative lymph nodes as established by imaging (pelvic and/or abdominal CT scan or MRI), nodal sampling, or dissection within the past 60 days (required for patients with 2-3 risk factors)

    • Abdominal imaging not required for a single intermediate-risk factor (these studies may be obtained at the discretion of the treating physician)
    • Lymph nodes that are equivocal or questionable by imaging allowed without biopsy if nodes ≤ 1.5 cm
    • Any node > 1.5 cm on imaging requires a negative biopsy
  • No evidence of bone metastases on bone scan within the past 60 days

    • Bone scan not required for patients with a single intermediate-risk factor (scan may be obtained at the discretion of the treating physician)
    • Equivocal bone scan findings allowed if plain film x-rays negative for metastasis

PATIENT CHARACTERISTICS:

  • Zubrod performance status 0-1
  • Absolute neutrophil count (ANC) ≥ 1,800/mm^3*
  • Platelet count ≥ 100,000/mm^3*
  • Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention to achieve level allowed)*
  • NOTE: *For patients undergoing brachytherapy only.
  • Fertile patients must use effective contraception during and for the 3 months after cessation of protocol treatment
  • No invasive malignancy or hematological malignancy (e.g., leukemia, lymphoma, myeloma) within the past 5 years except adequately treated non-melanomatous skin cancer

    • Prior diagnoses of carcinoma in situ allowed
  • No severe or active co-morbidity with any of the following:

    • Unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months
    • Transmural myocardial infarction within the past 6 months
    • Acute bacterial or fungal infection requiring intravenous antibiotics
    • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy, within the past 30 days
    • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects

      • Laboratory tests for liver function and coagulation parameters not required for entry into this protocol
    • AIDS based upon current Centers for Disease Control (CDC) definition

      • HIV testing not required for entry into this protocol
      • HIV-seropositive patients who do not meet criteria for diagnosis of AIDS allowed

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • No prior radical surgery (prostatectomy), high-intensity focused ultrasound, or cryosurgery for prostate cancer
  • No prior hormonal therapy, such as LHRH agonists (e.g., goserelin, leuprolide), antiandrogens (e.g., flutamide, bicalutamide), estrogens (e.g., DES), or bilateral orchiectomy
  • No finasteride within past 30 days (90 days for dutasteride)
  • No prior or concurrent cytotoxic chemotherapy for prostate cancer

    • Prior chemotherapy for a different cancer allowed
  • No prior radiotherapy (RT), including brachytherapy, to the region of the study cancer that would result in overlap of RT fields

    • Patients undergoing brachytherapy must have transrectal ultrasound confirmation of prostate volume < 60 cc, American Urological Association (AUA) score ≤ 15 within the past 60 days of registration, and no history of prior transurethral resection of the prostate (TURP)
    • TURP allowed for patients who receive external-beam radiation therapy only
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00936390

  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States, 35233
United States, Alaska
Fairbanks Memorial Hospital
Fairbanks, Alaska, United States, 99701
United States, Arizona
Arizona Center for Cancer Care-Peoria
Peoria, Arizona, United States, 85381
Saint Joseph's Hospital and Medical Center
Phoenix, Arizona, United States, 85013
21st Century Oncology-Scottsdale
Scottsdale, Arizona, United States, 85251
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
Arizona Oncology Services Foundation
Scottsdale, Arizona, United States, 85260
Arizona Oncology Associates-West Orange Grove
Tucson, Arizona, United States, 85704
United States, Arkansas
Mercy Cancer Center-Hot Springs
Hot Springs, Arkansas, United States, 71913
United States, California
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, United States, 95603
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States, 94704
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, United States, 91505
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, United States, 95682
Mercy San Juan Medical Center
Carmichael, California, United States, 95608
Enloe Medical Center
Chico, California, United States, 95926
21st Century Oncology - El Segundo
El Segundo, California, United States, 90245
Fresno Cancer Center
Fresno, California, United States, 93720
Saint Agnes Medical Center
Fresno, California, United States, 93720
Marin General Hospital
Greenbrae, California, United States, 94904
Veterans Administration Long Beach Medical Center
Long Beach, California, United States, 90822
Los Angeles County-USC Medical Center
Los Angeles, California, United States, 90033
USC / Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Memorial Medical Center
Modesto, California, United States, 95355
Kaiser Permanente Oakland-Broadway
Oakland, California, United States, 94611
Kaiser Permanente-Oakland
Oakland, California, United States, 94611
Desert Regional Medical Center
Palm Springs, California, United States, 92262
Stanford Cancer Institute
Palo Alto, California, United States, 94304
Feather River Cancer Center
Paradise, California, United States, 95969
Pomona Valley Hospital Medical Center
Pomona, California, United States, 91767
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cardova, California, United States, 95670
Kaiser Permanente-Redwood City
Redwood City, California, United States, 94063
Kaiser Permanente-Richmond
Richmond, California, United States, 94801
Rohnert Park Cancer Center
Rohnert Park, California, United States, 94928
Kaiser Permanente-Roseville
Roseville, California, United States, 95661
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, United States, 95661
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, United States, 95678
Sutter General Hospital
Sacramento, California, United States, 95816
Kaiser Permanente - Sacramento
Sacramento, California, United States, 95825
Mercy General Hospital Radiation Oncology Center
Sacramento, California, United States, 95819
Kaiser Permanente-South Sacramento
Sacramento, California, United States, 95823
South Sacramento Cancer Center
Sacramento, California, United States, 95823
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States, 95817
University of California San Diego
San Diego, California, United States, 92103
Kaiser Permanente-San Francisco
San Francisco, California, United States, 94115
UCSF Medical Center-Mount Zion
San Francisco, California, United States, 94115
California Pacific Medical Center-Pacific Campus
San Francisco, California, United States, 94118
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, United States, 95119
Kaiser Permanente San Leandro
San Leandro, California, United States, 94577
Kaiser Permanente-San Rafael
San Rafael, California, United States, 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States, 95051
Kaiser Permanente-Santa Rosa
Santa Rosa, California, United States, 95403
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, United States, 94080
Kaiser Permanente-South San Francisco
South San Francisco, California, United States, 94080
Kaiser Permanente-Stockton
Stockton, California, United States, 95210
David Grant United States Air Force Medical Center
Travis AFB, California, United States, 94535-1800
Tahoe Forest Cancer Center
Truckee, California, United States, 96161
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Vacaville, California, United States, 95687
Sutter Solano Medical Center/Cancer Center
Vallejo, California, United States, 94589
Kaiser Permanente-Walnut Creek
Walnut Creek, California, United States, 94596
United States, Colorado
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado, United States, 80012
University of Colorado Cancer Center - Anschutz Cancer Pavilion
Aurora, Colorado, United States, 80045
The Urology Center of Colorado
Denver, Colorado, United States, 80211
The Shaw Regional Cancer Center
Edwards, Colorado, United States, 81632
Poudre Valley Hospital
Fort Collins, Colorado, United States, 80524
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado, United States, 81502
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado, United States, 80120
United States, Connecticut
Hartford Hospital
Hartford, Connecticut, United States, 06102
Saint Francis Hospital and Medical Center
Hartford, Connecticut, United States, 06105
Yale-New Haven Hospital Saint Raphael Campus
Hew Haven, Connecticut, United States, 06511
Midstate Medical Center
Meriden, Connecticut, United States, 06451
The Hospital of Central Connecticut
New Britain, Connecticut, United States, 06050
United States, Delaware
Helen F Graham Cancer Center
Newark, Delaware, United States, 19713
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States, 19718
United States, Florida
University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States, 33442
Broward Health Medical Center
Fort Lauderdale, Florida, United States, 33316
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224-9980
Florida Hospital Kissimmee
Kissimmee, Florida, United States, 34744
Lakeland Regional Cancer Center
Lakeland, Florida, United States, 33805
The Watson Clinic
Lakeland, Florida, United States, 33805
Jackson Memorial Hospital-Holtz Children's Hospital
Miami, Florida, United States, 33136
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States, 33136
South Miami Hospital
Miami, Florida, United States, 33143
Florida Hospital Orlando
Orlando, Florida, United States, 32803
Bay Medical Center
Panama City, Florida, United States, 32401
James A. Haley Veterans Affairs Hospital
Tampa, Florida, United States, 33612
United States, Georgia
Northside Hospital
Atlanta, Georgia, United States, 30342
Piedmont Hospital
Atlanta, Georgia, United States, 30309
Emory University/Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Grady Health System
Atlanta, Georgia, United States, 30303
John B Amos Cancer Center
Columbus, Georgia, United States, 31904
Northside Hospital-Forsyth
Cumming, Georgia, United States, 30041
Atlanta VA Medical Center
Decatur, Georgia, United States, 30033
Piedmont Fayette Hospital
Fayetteville, Georgia, United States, 30214
Northeast Georgia Medical Center
Gainesville, Georgia, United States, 30501
Memorial University Medical Center
Savannah, Georgia, United States, 31404
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, United States, 31405
United States, Hawaii
Queen's Medical Center
Honolulu, Hawaii, United States, 96813
University of Hawaii Cancer Center
Honolulu, Hawaii, United States, 96813
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, United States, 96817
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, United States, 83706
Idaho Urologic Institute-Meridian
Meridian, Idaho, United States, 83642
Kootenai Cancer Center
Post Falls, Idaho, United States, 83854
United States, Illinois
Saint Anthony's Health
Alton, Illinois, United States, 62002
Memorial Hospital of Carbondale
Carbondale, Illinois, United States, 62902
Advocate Illinois Masonic Medical Center
Chicago, Illinois, United States, 60657
Northwestern University
Chicago, Illinois, United States, 60611
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States, 60612-3785
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States, 60637
Decatur Memorial Hospital
Decatur, Illinois, United States, 62526
Crossroads Cancer Center
Effingham, Illinois, United States, 62401
Hines Veterans Administration Hospital
Hines, Illinois, United States, 60141
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Pekin Cancer Treatment Center
Pekin, Illinois, United States, 61554
OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
Peoria, Illinois, United States, 61615-7827
OSF Saint Francis Medical Center
Peoria, Illinois, United States, 61637
SwedishAmerican Regional Cancer Center/ACT
Rockford, Illinois, United States, 61114
Saint John's Hospital
Springfield, Illinois, United States, 62702
Memorial Medical Center
Springfield, Illinois, United States, 62781-0001
Memorial and Saint Elizabeth's Health Care Services LLP
Swansea, Illinois, United States, 62226
United States, Indiana
Saint Vincent Anderson Regional Hospital/Cancer Center
Anderson, Indiana, United States, 46016
IU Health West Hospital
Avon, Indiana, United States, 46123
IU Health Bloomington
Bloomington, Indiana, United States, 47403
Radiation Oncology Associates PC
Fort Wayne, Indiana, United States, 46804
Parkview Hospital Randallia
Fort Wayne, Indiana, United States, 46805
IU Health Goshen Center for Cancer Care
Goshen, Indiana, United States, 46526
IU Health Central Indiana Cancer Centers-East
Indianapolis, Indiana, United States, 46219
IU Health Methodist Hospital
Indianapolis, Indiana, United States, 46202
Richard L. Roudebush Veterans Affairs Medical Center
Indianapolis, Indiana, United States, 46202
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, United States, 46202
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center
Ames, Iowa, United States, 50010
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa, United States, 50325
Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
Iowa Oncology Research Association CCOP
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, United States, 50309
Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa, United States, 50314
Mercy Medical Center - Des Moines
Des Moines, Iowa, United States, 50314
Iowa Lutheran Hospital
Des Moines, Iowa, United States, 50316
Finley Hospital
Dubuque, Iowa, United States, 52001
United States, Kansas
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, United States, 67801
Cancer Center of Kansas - El Dorado
El Dorado, Kansas, United States, 67042
Lawrence Memorial Hospital
Lawrence, Kansas, United States, 66044
Kansas City Cancer Centers-Southwest
Overland Park, Kansas, United States, 66210
Cancer Center of Kansas - Wellington
Wellington, Kansas, United States, 67152
Associates In Womens Health
Wichita, Kansas, United States, 67208
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas, United States, 67208
Cancer Center of Kansas - Main Office
Wichita, Kansas, United States, 67214
Via Christi Regional Medical Center
Wichita, Kansas, United States, 67214
Wesley Medical Center
Wichita, Kansas, United States, 67214
Wichita CCOP
Wichita, Kansas, United States, 67214
Cancer Center of Kansas - Winfield
Winfield, Kansas, United States, 67156
United States, Kentucky
Baptist Health Lexington
Lexington, Kentucky, United States, 40503
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, United States, 40536
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, United States, 40202
Owensboro Health Mitchell Memorial Cancer Center
Owensboro, Kentucky, United States, 42303
United States, Louisiana
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States, 70809
Tulane University Health Sciences Center
New Orleans, Louisiana, United States, 70112
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States, 70121
United States, Maine
Central Maine Medical Center
Lewiston, Maine, United States, 04240
Maine Medical Center- Scarborough Campus
Scarborough, Maine, United States, 04074
United States, Maryland
Anne Arundel Medical Center
Annapolis, Maryland, United States, 21401
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, United States, 21201
Greater Baltimore Medical Center
Baltimore, Maryland, United States, 21204
Saint Agnes Hospital
Baltimore, Maryland, United States, 21229
Upper Chesapeake Medical Center
Bel Air, Maryland, United States, 21015
Walter Reed National Military Medical Center
Bethesda, Maryland, United States, 20889-5600
Central Maryland Radiation Oncology in Howard County
Columbia, Maryland, United States, 21044
Tate Cancer Center
Glen Burnie, Maryland, United States, 21061
Holy Cross Hospital
Silver Spring, Maryland, United States, 20910
United States, Massachusetts
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States, 02114
Boston Medical Center
Boston, Massachusetts, United States, 02118
Mass General/North Shore Cancer Center
Danvers, Massachusetts, United States, 01923
Saint Anne's Hospital
Fall River, Massachusetts, United States, 02721
Cape Cod Hospital
Hyannis, Massachusetts, United States, 02601
Lowell General Hospital
Lowell, Massachusetts, United States, 01854
Berkshire Hematology Oncology PC
Pittsfield, Massachusetts, United States, 01201
Beth Israel Deaconess Hospital-Plymouth
Plymouth, Massachusetts, United States, 02360
Baystate Medical Center
Springfield, Massachusetts, United States, 01199
D'Amour Center for Cancer Care
Springfield, Massachusetts, United States, 01107
Saint Vincent Hospital/Reliant Medical Group
Worcester, Massachusetts, United States, 01608
United States, Michigan
Bixby Medical Center
Adrian, Michigan, United States, 49221
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States, 48109
Veteran's Administration Medical Center - Ann Arbor
Ann Arbor, Michigan, United States, 48105
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, United States, 48106-0995
Bronson Battle Creek
Battle Creek, Michigan, United States, 49017
McLaren-Bay Region
Bay City, Michigan, United States, 48708
Henry Ford Macomb Hospital
Clinton Township, Michigan, United States, 48038
Huron Valley-Sinai Hospital
Commerce, Michigan, United States, 48382
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Saint John Hospital and Medical Center
Detroit, Michigan, United States, 48236
Green Bay Oncology - Escanaba
Escanaba, Michigan, United States, 49431
Botsford General Hospital
Farmington, Michigan, United States, 48334
21st Century Oncology-Farmington Hills
Farmington Hills, Michigan, United States, 48334
Genesys Hurley Cancer Institute
Flint, Michigan, United States, 48503
Genesys Regional Medical Center-West Flint Campus
Flint, Michigan, United States, 48532
McLaren-Flint
Flint, Michigan, United States, 48532
Mercy Health Saint Mary's
Grand Rapids, Michigan, United States, 49503
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, United States, 49503
Green Bay Oncology - Iron Mountain
Iron Mountain, Michigan, United States, 49801
West Michigan Cancer Center
Kalamazoo, Michigan, United States, 49007
Bronson Methodist Hospital
Kalamazoo, Michigan, United States, 49007
Borgess Medical Center
Kalamazoo, Michigan, United States, 49001
Sparrow Hospital
Lansing, Michigan, United States, 48912
Great Lakes Cancer Institute-Lapeer Campus
Lapeer, Michigan, United States, 48446
McLaren-Macomb
Mount Clemens, Michigan, United States, 48043
McLaren-Central Michigan
Mount Pleasant, Michigan, United States, 48858
Mercy Health Mercy Campus
Muskegon, Michigan, United States, 49444
McLaren Cancer Institute-Owosso
Owosso, Michigan, United States, 48867
Northern Michigan Regional Hospital
Petoskey, Michigan, United States, 49770
Saint Joseph Mercy Oakland
Pontiac, Michigan, United States, 48341
Saint Joseph Mercy Port Huron
Port Huron, Michigan, United States, 48060
Crittenton Hospital
Rochester, Michigan, United States, 48307
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan, United States, 48073
Saint Mary's of Michigan
Saginaw, Michigan, United States, 48601
Downriver Center for Oncology
Trenton, Michigan, United States, 48183
21st Century Oncology-Troy
Troy, Michigan, United States, 48098
William Beaumont Hospital - Troy
Troy, Michigan, United States, 48098
Saint John Macomb-Oakland Hospital
Warren, Michigan, United States, 48093
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, United States, 48322
United States, Minnesota
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, United States, 56007
Sanford Clinic North-Bemidgi
Bemidji, Minnesota, United States, 56601
Miller-Dwan Hospital
Duluth, Minnesota, United States, 55805
Saint Luke's Hospital of Duluth
Duluth, Minnesota, United States, 55805
Fairview-Southdale Hospital
Edina, Minnesota, United States, 55435
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota, United States, 56001
Mayo Clinic
Rochester, Minnesota, United States, 55905
Regions Hospital
Saint Paul, Minnesota, United States, 55101
United States, Missouri
Saint Francis Medical Center
Cape Girardeau, Missouri, United States, 63703
Mercy Hospital-Joplin
Joplin, Missouri, United States, 64804
Kansas City Cancer Centers - North
Kansas City, Missouri, United States, 64154
Kansas City Cancer Center - South
Kansas City, Missouri, United States, 64131
Kansas City Cancer Center-Lee's Summit
Lee's Summit, Missouri, United States, 64064
Phelps County Regional Medical Center
Rolla, Missouri, United States, 65401
Saint Louis-Cape Girardeau CCOP
Saint Louis, Missouri, United States, 63141
Washington University School of Medicine
Saint Louis, Missouri, United States, 63110
Siteman Cancer Center-South County
Saint Louis, Missouri, United States, 63129
Barnes-Jewish West County Hospital
Saint Louis, Missouri, United States, 63141
Mercy Hospital Saint Louis
Saint Louis, Missouri, United States, 63141
Missouri Baptist Medical Center
Saint Louis, Missouri, United States, 63131
Siteman Cancer Center - Saint Peters
Saint Peters, Missouri, United States, 63376
CoxHealth South Hospital
Springfield, Missouri, United States, 65807
Mercy Hospital Springfield
Springfield, Missouri, United States, 65804
Cancer Research for the Ozarks NCORP
Springfield, Missouri, United States, 65804
United States, Montana
Montana Cancer Consortium CCOP
Billings, Montana, United States, 59101
Northern Rockies Radiation Oncology Center
Billings, Montana, United States, 59101
Billings Clinic Cancer Center
Billings, Montana, United States, 59107
Berdeaux, Donald MD (UIA Investigator)
Great Falls, Montana, United States, 59405
Great Falls Clinic
Great Falls, Montana, United States, 59405
United States, Nebraska
Saint Elizabeth Regional Medical Center
Lincoln, Nebraska, United States, 68510
Missouri Valley Cancer Consortium
Omaha, Nebraska, United States, 68106
Nebraska Methodist Hospital
Omaha, Nebraska, United States, 68114
Alegent Health Immanuel Medical Center
Omaha, Nebraska, United States, 68122
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, United States, 68124
Alegent Health Lakeside Hospital
Omaha, Nebraska, United States, 68130
Creighton University Medical Center
Omaha, Nebraska, United States, 68131
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
United States, New Hampshire
Concord Hospital
Concord, New Hampshire, United States, 03301
Exeter Hospital
Exeter, New Hampshire, United States, 03833
Cheshire Medical Center-Dartmouth-Hitchcock Keene
Keene, New Hampshire, United States, 03431
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Elliot Hospital
Manchester, New Hampshire, United States, 03103
United States, New Jersey
Ocean Medical Center
Brick, New Jersey, United States, 08724
Cooper Hospital University Medical Center
Camden, New Jersey, United States, 08103
Veterans Adminstration New Jersey Health Care System
East Orange, New Jersey, United States, 07018-1095
CentraState Medical Center
Freehold, New Jersey, United States, 07728
Princeton Radiation Oncology Center
Monroe, New Jersey, United States, 08831
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
Mount Holly, New Jersey, United States, 08060
Jersey Shore Medical Center
Neptune, New Jersey, United States, 07753
UMDNJ - Robert Wood Johnson University Hospital
New Brunswick, New Jersey, United States, 08903
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08903
UMDNJ - New Jersey Medical School
Newark, New Jersey, United States, 07103
Newark Beth Israel Medical Center
Newark, New Jersey, United States, 07112
The Medical Center At Princeton
Princeton, New Jersey, United States, 08540-3298
Riverview Medical Center/Booker Cancer Center
Red Bank, New Jersey, United States, 07701
Sparta Cancer Treatment Center
Sparta, New Jersey, United States, 07871
Community Medical Center
Toms River, New Jersey, United States, 08755
Virtua West Jersey Hospital Voorhees
Voorhees, New Jersey, United States, 08043
MD Anderson Cancer Center at Cooper-Voorhees
Voorhees, New Jersey, United States, 08043
Prostate Cancer Center of New Jersey
West Orange, New Jersey, United States, 07052
United States, New Mexico
Lovelace Medical Center-Downtown
Albuquerque, New Mexico, United States, 87102
University of New Mexico
Albuquerque, New Mexico, United States, 87102
University of New Mexico Cancer Center
Albuquerque, New Mexico, United States, 87106
Radiation Oncology Associates
Albuquerque, New Mexico, United States, 87109
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico, United States, 88011
United States, New York
New York Oncology Hematology PC - Albany
Albany, New York, United States, 12206
Saint Peters Hospital-Albany
Albany, New York, United States, 12208
Southside Hospital
Bay Shore, New York, United States, 11706
Lourdes Hospital
Binghamton, New York, United States, 13905
Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
Brooklyn, New York, United States, 11209
State University of New York Downstate Medical Center
Brooklyn, New York, United States, 11203
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Sands Cancer Center
Canandiaqua, New York, United States, 14424
Mary Imogene Bassett Hospital
Cooperstown, New York, United States, 13326
Arnot Ogden Medical Center/Falck Cancer Center
Elmira, New York, United States, 14905
North Shore University Hospital
Manhasset, New York, United States, 11030
North Shore-LIJ Health System NCORP
Manhasset, New York, United States, 11030
Long Island Jewish Medical Center
New Hyde Park, New York, United States, 11040
North Shore-LIJ Health System/Center for Advanced Medicine
New Hyde Park, New York, United States, 11040
Columbia University Medical Center
New York, New York, United States, 10032
Hudson Valley Oncology Associates
Poughkeepsie, New York, United States, 12601
University of Rochester
Rochester, New York, United States, 14642
University Radiation Oncology
Rochester, New York, United States, 14626
Highland Hospital
Rochester, New York, United States, 14620
United States, North Carolina
Randolph Hospital
Asheboro, North Carolina, United States, 27203
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Duke University Medical Center
Durham, North Carolina, United States, 27710
Cone Health Cancer Center
Greensboro, North Carolina, United States, 27403
The Coleman Radiation Center-Carteret General Hospital
Morehead City, North Carolina, United States, 28557
CarolinaEast Health System-Medical Center
New Bern, North Carolina, United States, 28560
Duke Cancer Institute Macon Pond
Raleigh, North Carolina, United States, 27607
Rex Cancer Center
Raleigh, North Carolina, United States, 27607
South Atlantic Radiation Oncology
Supply, North Carolina, United States, 28462
Coastal Carolina Radiation Oncology
Wilmington, North Carolina, United States, 28401
New Hanover Regional Medical Center/Zimmer Cancer Center
Wilmington, North Carolina, United States, 28401
Southeast Cancer Consortium-Upstate NCORP
Winston-Salem, North Carolina, United States, 27104
United States, North Dakota
Mid Dakota Clinic
Bismarck, North Dakota, United States, 58501
Sanford Bismarck Medical Center
Bismarck, North Dakota, United States, 58501
Saint Alexius Medical Center
Bismarck, North Dakota, United States, 58501
Sanford Clinic North-Fargo
Fargo, North Dakota, United States, 58122
Sanford Medical Center-Fargo
Fargo, North Dakota, United States, 58122
Trinity Cancer Care Center
Minot, North Dakota, United States, 58701
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center
Akron, Ohio, United States, 44304
Akron General Medical Center
Akron, Ohio, United States, 44307
Summa Barberton Hospital
Barberton, Ohio, United States, 44203
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio, United States, 44122
Geaugra Hospital
Chardon, Ohio, United States, 44024
Adena Regional Medical Center
Chillicothe, Ohio, United States, 45601
University of Cincinnati
Cincinnati, Ohio, United States, 45267
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio, United States, 44111
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Case Western Reserve University
Cleveland, Ohio, United States, 44106
Doctors Hospital
Columbus, Ohio, United States, 43228
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210
Riverside Methodist Hospital
Columbus, Ohio, United States, 43214
Columbus CCOP
Columbus, Ohio, United States, 43215
Grant Medical Center
Columbus, Ohio, United States, 43215
The Mark H Zangmeister Center
Columbus, Ohio, United States, 43219
Mount Carmel Health Center West
Columbus, Ohio, United States, 43222
Grady Memorial Hospital
Delaware, Ohio, United States, 43015
Mercy Cancer Center-Elyria
Elyria, Ohio, United States, 44035
Cleveland Clinic Cancer Center Independence
Independence, Ohio, United States, 44131
Marietta Memorial Hospital
Marietta, Ohio, United States, 45750
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio, United States, 43537
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, United States, 44124
Summa Health Center at Lake Medina
Medina, Ohio, United States, 44256
Lake University Ireland Cancer Center
Mentor, Ohio, United States, 44060
Southwest General Health Center Ireland Cancer Center
Middleburg Heights, Ohio, United States, 44130
Licking Memorial Hospital
Newark, Ohio, United States, 43055
Saint Charles Hospital
Oregon, Ohio, United States, 43616
University Hospitals Parma Medical Center
Parma, Ohio, United States, 44129
Southern Ohio Medical Center
Portsmouth, Ohio, United States, 45662
Robinson Radiation Oncology
Ravenna, Ohio, United States, 44266
Cancer Care Center, Incorporated
Salem, Ohio, United States, 44460
North Coast Cancer Care
Sandusky, Ohio, United States, 44870
Ireland Cancer Center at Firelands Regional Medical Center
Sandusky, Ohio, United States, 44870
Flower Hospital
Sylvania, Ohio, United States, 43560
University of Toledo
Toledo, Ohio, United States, 43614
Mercy Saint Anne Hospital
Toledo, Ohio, United States, 43623
University Pointe
West Chester, Ohio, United States, 45069
Saint Ann's Hospital
Westerville, Ohio, United States, 43081
UHHS-Westlake Medical Center
Westlake, Ohio, United States, 44145
Cancer Treatment Center
Wooster, Ohio, United States, 44691
Cleveland Clinic Wooster Specialty Center
Wooster, Ohio, United States, 44691
Wright-Patterson Medical Center
Wright-Patterson Afb, Ohio, United States, 45433-5529
Genesis HealthCare System
Zanesville, Ohio, United States, 43701
United States, Oklahoma
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
United States, Oregon
Clackamas Radiation Oncology Center
Clackamas, Oregon, United States, 97015
Willamette Valley Cancer Center
Eugene, Oregon, United States, 97401
Three Rivers Community Hospital
Grants Pass, Oregon, United States, 97527
Legacy Mount Hood Medical Center
Gresham, Oregon, United States, 97030
Rogue Valley Medical Center
Medford, Oregon, United States, 97504
Providence Medford Medical Center
Medford, Oregon, United States, 97504
Asante Health System
Medford, Oregon, United States, 97504
Providence Milwaukie Hospital
Milwaukie, Oregon, United States, 97222
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon, United States, 97210
Providence Portland Medical Center
Portland, Oregon, United States, 97213
Western Oncology Research Consortium
Portland, Oregon, United States, 97213
Providence Saint Vincent Medical Center
Portland, Oregon, United States, 97225
Legacy Meridian Park Hospital
Tualatin, Oregon, United States, 97062
United States, Pennsylvania
Abington Memorial Hospital
Abington, Pennsylvania, United States, 19001
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania, United States, 18015
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, United States, 19010
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Mercy Fitzgerald Hospital
Darby, Pennsylvania, United States, 19023-1291
Delaware County Memorial Hospital
Drexel Hill, Pennsylvania, United States, 19026
Northeast Radiation Oncology Center
Dunmore, Pennsylvania, United States, 18512
The Regional Cancer Center
Erie, Pennsylvania, United States, 16505
Fox Chase Cancer Center Buckingham
Furlong, Pennsylvania, United States, 18925
Adams Cancer Center
Gettysburg, Pennsylvania, United States, 17325
Cherry Tree Cancer Center
Hanover, Pennsylvania, United States, 17331
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, United States, 17033-0850
Academic Urology Prostate Center
King of Prussia, Pennsylvania, United States, 19406
Saint Mary Medical and Regional Cancer Center
Langhorne, Pennsylvania, United States, 19047
Upper Delaware Valley Cancer Center
Milford, Pennsylvania, United States, 18337
Paoli Memorial Hospital
Paoli, Pennsylvania, United States, 19301
Albert Einstein Medical Center
Philadelphia, Pennsylvania, United States, 19141
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
Temple University Hospital
Philadelphia, Pennsylvania, United States, 19140
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19107
VA Pittsburgh Healthcare System
Pittsburgh, Pennsylvania, United States, 15240
Reading Hospital
West Reading, Pennsylvania, United States, 19611
Lankenau Medical Center
Wynnewood, Pennsylvania, United States, 19096
Mainline Health CCOP
Wynnewood, Pennsylvania, United States, 19096
WellSpan Health-York Hospital
York, Pennsylvania, United States, 17405
United States, South Carolina
AnMed Health Hospital
Anderson, South Carolina, United States, 29621
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Greenville Health System Cancer Institute-Eastside
Greenville, South Carolina, United States, 29615
Greenville Health System Cancer Institute-Faris
Greenville, South Carolina, United States, 29605
Self Regional Healthcare
Greenwood, South Carolina, United States, 29646
Greenville Health System Cancer Institute-Greer
Greer, South Carolina, United States, 29650
Gibbs Cancer Center-Pelham
Greer, South Carolina, United States, 29651
Carolina Regional Cancer Center
Myrtle Beach, South Carolina, United States, 29577
Greenville Health System Cancer Institute-Seneca
Seneca, South Carolina, United States, 29672
Greenville Health System Cancer Institute-Spartanburg
Spartanburg, South Carolina, United States, 29307
Spartanburg Medical Center
Spartanburg, South Carolina, United States, 29303
United States, South Dakota
Rapid City Regional Hospital
Rapid City, South Dakota, United States, 57701
United States, Tennessee
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee, United States, 37660
Thompson Cancer Survival Center
Knoxville, Tennessee, United States, 37916
Blount Memorial Hospital
Maryville, Tennessee, United States, 37804
United States, Texas
Texas Oncology-Arlington South
Arlington, Texas, United States, 76014
Texas Oncology-Austin Midtown
Austin, Texas, United States, 78705
Texas Oncology - Central Austin Cancer Center
Austin, Texas, United States, 78731
Texas Oncology - South Austin Cancer Center
Austin, Texas, United States, 78745
Texas Oncology Bedford
Bedford, Texas, United States, 76022
Texas Cancer Center - Medical City Dallas
Dallas, Texas, United States, 75230
Texas Oncology Methodist Charlton Cancer Center
Dallas, Texas, United States, 75237
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, United States, 75390
Texas Oncology-Denton South
Denton, Texas, United States, 76210
Brooke Army Medical Center
Fort Sam Houston, Texas, United States, 78234
The Klabzuba Cancer Center
Fort Worth, Texas, United States, 76104
University of Texas Medical Branch
Galveston, Texas, United States, 77555-0565
Memorial Hermann Memorial City Medical Center
Houston, Texas, United States, 77024
M D Anderson Cancer Center
Houston, Texas, United States, 77030
UTMB Cancer Center at Victory Lakes
League City, Texas, United States, 77573
Texas Oncology - Lewisville
Lewisville, Texas, United States, 75067
Texas Oncology-Longview Cancer Center
Longview, Texas, United States, 75601
West Texas Cancer Center
Odessa, Texas, United States, 79761
Texas Oncology-Seton Williamson
Round Rock, Texas, United States, 78665
Texas Oncology - Round Rock Cancer Center
Round Rock, Texas, United States, 78681
Texas Cancer Center-Sherman
Sherman, Texas, United States, 75090
Texas Oncology Cancer Center Sugar Land
Sugar Land, Texas, United States, 77479
Texas Oncology-Wichita Falls Texoma Cancer Center
Wichita Falls, Texas, United States, 76310
United States, Utah
Sandra L Maxwell Cancer Center
Cedar City, Utah, United States, 84720
Intermountain Medical Center
Murray, Utah, United States, 84157
McKay-Dee Hospital Center
Ogden, Utah, United States, 84403
Utah Valley Regional Medical Center
Provo, Utah, United States, 84604
Dixie Medical Center Regional Cancer Center
Saint George, Utah, United States, 84770
Utah Cancer Specialists-Salt Lake City
Salt Lake City, Utah, United States, 84106
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, United States, 84112
LDS Hospital
Salt Lake City, Utah, United States, 84143
United States, Vermont
Southwestern Vermont Medical Center
Bennington, Vermont, United States, 05201
Rutland Regional Medical Center
Rutland, Vermont, United States, 05701
Norris Cotton Cancer Center-North
Saint Johnsbury, Vermont, United States, 05819
United States, Virginia
Inova Alexandria Hospital
Alexandria, Virginia, United States, 22304
Danville Regional Medical Center
Danville, Virginia, United States, 24541
Augusta Health Cancer Center
Fishersville, Virginia, United States, 22939
Sentara Cancer Institute at Sentara CarePlex Hospital
Hampton, Virginia, United States, 23666
Sentara Rockingham Memorial Hospital Hahn Cancer Center
Harrisonburg, Virginia, United States, 22801
Sentara Hospitals
Norfolk, Virginia, United States, 23507
Southwest VA Regional Cancer Center
Norton, Virginia, United States, 24273
Naval Medical Center - Portsmouth
Portsmouth, Virginia, United States, 23708-2197
Oncology and Hematology Associates of Southwest Virginia
Roanoke, Virginia, United States, 24014
Sentara Virginia Beach General Hospital
Virginia Beach, Virginia, United States, 23454
United States, Washington
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, United States, 98225
Saint Francis Hospital
Federal Way, Washington, United States, 98003
Virginia Mason CCOP
Seattle, Washington, United States, 98101
Virginia Mason Medical Center
Seattle, Washington, United States, 98101
Cancer Care Northwest - Spokane South
Spokane, Washington, United States, 99202
Cancer Care Northwest-North Spokane
Spokane, Washington, United States, 99218
Legacy Salmon Creek Hospital
Vancouver, Washington, United States, 98686
Compass Oncology Vancouver
Vancouver, Washington, United States, 98684
PeaceHealth Southwest Medical Center
Vancouver, Washington, United States, 98664
United States, Wisconsin
Appleton Medical Center
Appleton, Wisconsin, United States, 54911
Saint Mary's Hospital
Green Bay, Wisconsin, United States, 54303
Bellin Memorial Hospital
Green Bay, Wisconsin, United States, 54301
Saint Vincent Hospital
Green Bay, Wisconsin, United States, 54301
Green Bay Oncology Limited at Saint Mary's Hospital
Green Bay, Wisconsin, United States, 54303
Aurora BayCare Medical Center
Green Bay, Wisconsin, United States, 54311-6519
Green Bay Oncology at Saint Vincent Hospital
Green Bay, Wisconsin, United States, 54301-3526
UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin, United States, 53038
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin, United States, 54601
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States, 54601
Bay Area Medical Center
Marinette, Wisconsin, United States, 54143
Vince Lombardi Cancer Clinic-Marinette
Marinette, Wisconsin, United States, 54143
Community Memorial Hospital
Menomonee Falls, Wisconsin, United States, 53051
Columbia Saint Mary's Hospital - Ozaukee
Mequon, Wisconsin, United States, 53097
Columbia Saint Mary's Water Tower Medical Commons
Milwaukee, Wisconsin, United States, 53211
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, United States, 53215
Froedtert and the Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Zablocki Veterans Administration Medical Center
Milwaukee, Wisconsin, United States, 53295
Green Bay Oncology - Oconto Falls
Oconto Falls, Wisconsin, United States, 54154
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, United States, 54904
Wheaton Franciscan Cancer Care - All Saints
Racine, Wisconsin, United States, 53405
Door County Cancer Center
Sturgeon Bay, Wisconsin, United States, 54235-1495
Green Bay Oncology - Sturgeon Bay
Sturgeon Bay, Wisconsin, United States, 54235
Aurora Medical Center in Summit
Summit, Wisconsin, United States, 53066
Aurora West Allis Medical Center
West Allis, Wisconsin, United States, 53227
The Alyce and Elmore Kraemer Cancer Care Center
West Bend, Wisconsin, United States, 53095
Riverview Hospital
Wisconsin Rapids, Wisconsin, United States, 54494
United States, Wyoming
Welch Cancer Center
Sheridan, Wyoming, United States, 82801
Canada, Alberta
Tom Baker Cancer Centre
Calgary, Alberta, Canada, T2N 4N2
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Canada, British Columbia
BCCA-Cancer Centre for the Southern Interior
Kelowna, British Columbia, Canada, V1Y 5L3
BCCA-Vancouver Island Cancer Centre
Victoria, British Columbia, Canada, V8R 6V5
Canada, New Brunswick
Atlantic Health Sciences Corporation-Saint John Regional Hospital
Saint John, New Brunswick, Canada, E2L 4L2
Canada, Nova Scotia
QEII Health Sciences Centre/Capital District Health Authority
Halifax, Nova Scotia, Canada, B3H 1V8
Canada, Ontario
Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, Canada, L8V 5C2
London Regional Cancer Program
London, Ontario, Canada, N6A 4L6
Ottawa Health Research Institute-General Division
Ottawa, Ontario, Canada, K1H 1C4
Irving Greenberg Family Cancer Centre
Ottawa, Ontario, Canada, K2H 8P4
Thunder Bay Regional Health Science Centre
Thunder Bay, Ontario, Canada, P7B 6V4
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Canada, Quebec
Hopital Maisonneuve-Rosemont
Montreal, Quebec, Canada, H1T 2M4
CHUM - Hopital Notre-Dame
Montreal, Quebec, Canada, H2L 4M1
McGill University Department of Oncology
Montreal, Quebec, Canada, H2W 1S6
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Quebec City, Quebec, Canada, G1R 2J6
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada, J1H 5N4
Canada, Saskatchewan
Allan Blair Cancer Centre
Regina, Saskatchewan, Canada, S4T 7T1
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada, S7N 4H4
Sponsors and Collaborators
Radiation Therapy Oncology Group
National Cancer Institute (NCI)
NRG Oncology
Investigators
Study Chair: Alvaro A. Martinez, MD, FACR 21st Century Oncology - Michigan Institute for Radiation Oncology
  More Information

Responsible Party: Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier: NCT00936390     History of Changes
Other Study ID Numbers: RTOG 0815  CDR0000648194  NCI-2011-01948 
Study First Received: July 8, 2009
Last Updated: March 8, 2016
Health Authority: United States: Federal Government

Keywords provided by Radiation Therapy Oncology Group:
adenocarcinoma of the prostate
stage IIB prostate cancer
stage IIA prostate cancer

Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Neoplasms
Genital Diseases, Male
Prostatic Diseases
Goserelin
Triptorelin Pamoate
Leuprolide
Flutamide
Bicalutamide
Buserelin
Androgens
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Androgen Antagonists
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Luteolytic Agents
Contraceptive Agents, Female
Contraceptive Agents
Reproductive Control Agents
Fertility Agents, Female
Fertility Agents
Hormones

ClinicalTrials.gov processed this record on July 27, 2016