Longitudinal Study in Perimenopausal Women With Risk Factors for Atherosclerosis
|ClinicalTrials.gov Identifier: NCT00921011|
Recruitment Status : Completed
First Posted : June 16, 2009
Last Update Posted : April 5, 2018
The study hypothesis (or theory) is that monthly loss of iron before menopause may reduce women's risk of hardening of the arteries, or atherosclerosis.
This study uses noninvasive, noncontrast magnetic resonance imaging (MRI) of arteries in women entering menopause. This will help to determine if there is a correlation between iron accumulation and hardening of the arteries. In addition, blood levels of hormones will be measured to help show differences due to hormone levels vs. iron accumulation.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||177 participants|
|Official Title:||Iron and Atherosclerosis: Longitudinal Study in Perimenopausal Women With Risk Factors for Atherosclerosis|
|Study Start Date :||May 2009|
|Actual Primary Completion Date :||February 2018|
|Actual Study Completion Date :||March 2018|
Women at the beginning stages of menopause
- vessel wall changes over time that precede plaque buildup [ Time Frame: baseline, 1-year follow-up and 2-year follow-up ]
- development of cardiovascular disease [ Time Frame: annually for 4 years after baseline visit ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00921011
|United States, Ohio|
|The Ohio State Univeristy Medical Center|
|Columbus, Ohio, United States, 43210|
|Principal Investigator:||Subha V Raman, MD||Ohio State University|