Trial record 1 of 1 for:    N0577
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Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2016 by Alliance for Clinical Trials in Oncology
Sponsor:
Collaborators:
National Cancer Institute (NCI)
European Organisation for Research and Treatment Center (EORTC)
NCIC Clinical Trials Group
Information provided by (Responsible Party):
Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier:
NCT00887146
First received: April 22, 2009
Last updated: March 17, 2016
Last verified: March 2016
  Purpose
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma.

Condition Intervention Phase
Brain and Central Nervous System Tumors
Drug: concomitant temozolomide (TMZ)
Radiation: radiotherapy
Drug: procarbazine
Drug: adjuvant temozolomide (TMZ)
Drug: CCNU
Drug: vincristine
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Phase III Intergroup Study of Radiotherapy With Concomitant and Adjuvant Temozolomide Versus Radiotherapy With Adjuvant PCV Chemotherapy in Patients With 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma

Resource links provided by NLM:


Further study details as provided by Alliance for Clinical Trials in Oncology:

Primary Outcome Measures:
  • Progression-free survival [ Time Frame: Up to 5 years post-treatment ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Overall survival [ Time Frame: Up to 5 years post-treatment ] [ Designated as safety issue: No ]
  • Objective tumor response [ Time Frame: Up to 5 years post-treatment ] [ Designated as safety issue: No ]
  • Treatment-related adverse event as per the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 [ Time Frame: Up to 5 years post-treatment ] [ Designated as safety issue: Yes ]
  • Time to progression (eg, clinical progression, radiographic progression or neurocognitive progression) [ Time Frame: Up to 5 years post-treatment ] [ Designated as safety issue: No ]

Estimated Enrollment: 360
Study Start Date: September 2009
Estimated Primary Completion Date: December 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Arm A - Radiotherapy followed by PCV

Patients undergo radiotherapy (RT) 5 days per week for about 6-7 weeks. (Cycle 1 is about 6 to 7 weeks)

Cycle 2 rest period is about 4 weeks.

Patients receive PCV chemotherapy for about 6-7 weeks, a total of 6 cycles.

Radiation: radiotherapy Drug: procarbazine
Days 8-21: 60 mg/m^2 orally
Drug: CCNU
Day 1: 110 mg/m^2 orally
Drug: vincristine
Days 8 and 29: 1.4 mg/m^2 IV
Active Comparator: Arm B - Radiotherapy + TMZ followed by TMZ

Patients undergo radiotherapy (RT) and temozolomide (TMZ) treatment for 5 days per week for about 6-7 weeks (Cycle 1).

Cycle 2 rest period is about 4 weeks.

Patients receive adjuvant temozolomide for about 4 weeks, a total of 6 cycles. TMZ may be extended to 12 cycles if the patient shows acceptable tolerance and no evidence of progression.

Drug: concomitant temozolomide (TMZ)
75 mg/m^2, orally daily
Radiation: radiotherapy Drug: adjuvant temozolomide (TMZ)
150 or 200 mg/m^2 orally

Detailed Description:

This study will be a randomized phase III for patients with newly diagnosed co-deleted 1p/19q anaplastic glioma or high risk low grade glioma. The trial will only enroll patients with 1p/19q co-deletion. This study includes two arms as described in the "Arms" section. A dynamic allocation procedure will be used to allocate an equal number of patients to different arms (Arms A:B = 1:1). This procedure will balance the marginal distributions of the stratification factors among arms. The stratification factors that will be used are cooperative groups (EORTC vs. all North American groups), age (≤ 50 vs. > 50), performance score (ECOG 0-1 vs. 2), and tumor grade (anaplastic glioma vs. low grade glioma).

The primary goal is to determine whether patients who receive radiotherapy with concomitant temozolomide (TMZ) followed by adjuvant temozolomide (RT + TMZ --> TMZ) (Arm B) have a marginally better progression free survival (PFS) as compared with patients who receive radiotherapy followed by PCV chemotherapy (RT --> PCV)(Arm A).

Secondary Goals:

  1. Time to Progression - To determine whether patients who receive (RT + TMZ --> TMZ) have a significantly longer time to progression (clinical or radiographic progression) as compared with patients who receive radiotherapy followed by adjuvant PCV chemotherapy (RT --> PCV).
  2. Correlation between exploratory biomarkers and survival - To determine whether there is a difference in survival based on t(1;19)(q10, p10) translocation status and MGMT promoter hypermethylation status.
  3. Descriptive Comparisons of Additional Secondary Endpoints - To perform descriptive comparisons of additional secondary outcome endpoints, including overall survival, objective tumor response, prognostic factor analysis and quality of life.
  4. Toxicity - To determine the toxicity of the treatment in each arm and perform descriptive comparisons.
  5. Neurocognitive and Quality of Life (QOL) Effects - To determine the neurocognitive and QOL effects in patients treated on this protocol and correlate these results with outcome endpoints.
  6. Banking of Biospecimens and Neuroimaging Studies - To store blood products (i.e., plasma, DNA and buffy coat), tumor tissue and MRI/CT images for future scientific investigations.

After completion of study treatment, patients are followed every 12 weeks for 1 year, then every 4 months for 2 years and then every 6 months until progressive disease or until the end of study participation.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Pre-Registration Inclusion Criteria:

Central Pathology Review Submission: This review is mandatory prior to registration to confirm eligibility. Patients must be willing to submit tissue samples for mandatory central pathology review submission and deletion status determination. It should be initiated as soon after surgery as possible.

Registration Inclusion Criteria:

  1. Age ≥ 18 years
  2. Newly diagnosed and ≤ 3 months from surgical diagnosis
  3. Histological confirmation of anaplastic glioma (oligodendroglioma, mixed, or astrocytoma [WHO grade 2 or 3] or low grade glioma [WHO grade 2], as determined by pre-registration central pathology review. Note: Mixed gliomas are eligible, regardless of the degree of astrocytic or oligodendrocytic predominance, as long as the tumor is also co-deleted for 1p and 19q.
  4. Patients with codeleted low grade gliomas must also be considered "high risk" by clinical criteria utilized in RTOG 9802 and must be either: age ≥ 40 and any surgical therapy or age < 40 and subtotal resection or biopsy.
  5. Tumor tissue must show co-deletion for the relevant portions of chromosomes 1p and 19q by FISH analysis, as defined by the testing laboratory.
  6. Surgery (partial or gross total resection or biopsy) must be performed ≥ 2 weeks prior to registration. Patient must have recovered from the effects of surgery.
  7. The following laboratory values obtained ≤ 21 days prior to registration.

    1. Absolute neutrophil count (ANC) ≥ 1500/mm^3
    2. Platelet (PLTs) count ≥ 100,000/mm^3
    3. Hemoglobin (Hgb) > 9.0g/dL
    4. Total bilirubin ≤ 1.5 x upper limit of normal (ULN)
    5. Serum glutamic oxaloacetic transaminase (SGOT) aspartate transaminase (AST) ≤ 3 x ULN
    6. Creatinine ≤ 1.5 x ULN
  8. Negative serum or urine pregnancy test done ≤ 7 days prior to registration for women of childbearing potential only.
  9. Willing and able to complete neurocognitive testing without assistance and the Quality of Life (QOL) questionnaires with or without assistance
  10. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
  11. Provide informed written consent.
  12. Willing to return to enrolling institution for follow-up during the Active Monitoring Phase (ie, active treatment and observation portion) of the study
  13. Mandatory Tissue Samples for Correlative Research -Patient willing to provide tissue samples for correlative research purposes

Registration Exclusion Criteria:

  1. Fetal/Newborn Toxicity: Any of the following because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects: Pregnant women, nursing women, men or women of childbearing potential who are unwilling to employ adequate contraception during this study and for up to 6 months following the completion of temozolomide treatments.
  2. Received any prior surgery, radiation therapy or chemotherapy for any central nervous system (CNS) neoplasm. Note: Patients who have had a prior low grade glioma with or without surgery and who now have anaplastic glioma with no prior radiation or chemotherapy are eligible for the study.
  3. Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.
  4. Concomitant serious immunocompromised status (other than that related to concomitant steroids) that would compromise the safety of the patient on the study.
  5. Patients known to be Human Immunodeficiency Virus (HIV) positive and currently receiving retroviral therapy. Note: Patients known to be HIV positive, but without clinical evidence of an immunocompromised state, are eligible for the study.
  6. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
  7. Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm.
  8. Other active malignancy within 5 years of registration. Exceptions:

    Non-melanotic skin cancer or carcinoma in situ of the cervix. Note: If there is a history of prior malignancy, the patient must not be receiving other specific treatment (other than hormonal therapy) for their cancer.

  9. History of myocardial infarction ≤ 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias.
  10. Recent history of hepatitis infection or treating physician determined that the patient would be at significant risk of reactivation of hepatitis.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00887146

Contacts
Contact: Kurt Jaeckle, MD 904-953-7102

  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Cancer Center Recruiting
Birmingham, Alabama, United States, 35233
Contact: John Fiveash, MD    205-975-0224      
United States, Alaska
Providence Alaska Medical Center Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Alaska Breast Care and Surgery LLC Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Alaska Oncology and Hematology LLC Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Alaska Regional Hospital Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Alaska Women's Cancer Care Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Anchorage Oncology Centre Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Katmai Oncology Group Recruiting
Anchorage, Alaska, United States, 99508
Contact: Keith Lanier, MD    503-216-6300      
Anchorage Radiation Therapy Center Recruiting
Anchorage, Alaska, United States, 99504
Contact: Keith Lanier, MD    503-216-6300      
United States, Arizona
Saint Joseph's Hospital and Medical Center Recruiting
Phoenix, Arizona, United States, 85013
Contact: David Brachman, MD    602-240-3370      
Arizona Oncology Services Foundation Recruiting
Scottsdale, Arizona, United States, 85260
Contact: David Brachman, MD    602-240-3370      
United States, Arkansas
CHI Saint Vincent Cancer Center Hot Springs Recruiting
Hot Springs, Arkansas, United States, 71913
Contact: Mehmet Copur, MD    308-398-5450      
United States, California
Providence Saint Joseph Medical Center/Disney Family Cancer Center Recruiting
Burbank, California, United States, 91505
Contact: Keith Lanier, MD    503-216-6300      
Comprehensive Cancer Care and Research Institute of Colorado LLC Recruiting
Englewood, California, United States, 80113
Contact: Keren Sturtz, MD    303-777-2663      
California Cancer Center - North Fresno Recruiting
Fresno, California, United States, 93720
Contact: Uzair Chaudhary, MD    559-256-9680      
Kaiser Permanente Los Angeles Medical Center Recruiting
Los Angeles, California, United States, 90027
Contact: Michael Girvigian, MD    323-783-8930      
Cedars-Sinai Medical Center Recruiting
Los Angeles, California, United States, 90048
Contact: Jethro Hu, MD    310-423-8100      
United States, Colorado
Rocky Mountain Cancer Centers-Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz, MD    303-777-2663      
The Medical Center of Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz, MD    303-777-2663      
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers-Boulder Recruiting
Boulder, Colorado, United States, 80304
Contact: Keren Sturtz, MD    303-777-2663      
Memorial Hospital Colorado Springs Recruiting
Colorado Springs, Colorado, United States, 80909
Contact: Brian Kavanagh, MD    720-848-0154      
Rocky Mountain Cancer Centers-Penrose Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz, MD    303-777-2663      
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz, MD    303-777-2663      
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Keren Sturtz, MD    303-777-2663      
Colorado Blood Cancer Institute Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz, MD    303-777-2663      
Presbyterian - Saint Lukes Medical Center - Health One Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers-Midtown Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers-Rose Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz, MD    303-649-5469      
Rose Medical Center Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz, MD    303-777-2663      
Colorado Cancer Research Program NCORP Recruiting
Denver, Colorado, United States, 80222
Contact: Keren Sturtz, MD    303-777-2663      
Mercy Medical Center Recruiting
Durango, Colorado, United States, 81301
Contact: Keren Sturtz, MD    303-777-2663      
Mountain Blue Cancer Care Center Recruiting
Golden, Colorado, United States, 80401
Contact: Keren Sturtz, MD    303-777-2663      
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers-Greenwood Village Recruiting
Greenwood Village, Colorado, United States, 80111
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers-Lakewood Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz, MD    303-777-2663      
Saint Anthony Hospital Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz, MD    303-777-2663      
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers-Littleton Recruiting
Littleton, Colorado, United States, 80120
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers-Sky Ridge Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz, MD    303-649-5469      
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers-Longmont Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz, MD    303-777-2663      
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz, MD    303-777-2663      
Parker Adventist Hospital Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers-Parker Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz, MD    303-777-2663      
Saint Mary Corwin Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers - Pueblo Recruiting
Pueblo, Colorado, United States, 81008
Contact: Keren Sturtz, MD    303-777-2663      
Rocky Mountain Cancer Centers-Thornton Recruiting
Thornton, Colorado, United States, 80260
Contact: Keren Sturtz, MD    303-777-2663      
United States, Florida
John Fitzgerald Kennedy Medical Center Recruiting
Atlantis, Florida, United States, 33462
Contact: Georges Hatoum, MD    561-548-1414      
Mayo Clinic in Florida Recruiting
Jacksonville, Florida, United States, 32224
Contact: Kurt Jaeckle, MD    904-953-7102      
Baptist Cancer Institute Recruiting
Jacksonville, Florida, United States, 32207
Contact: Robert Zaiden, MD    904-202-7051      
United States, Georgia
Piedmont Hospital Recruiting
Atlanta, Georgia, United States, 30309
Contact: Adam Nowlan, MD    404-605-4924      
Geisinger Medical Group Recruiting
State College, Georgia, United States, 16801
Contact: Scott Turner, MD    319-363-2690      
United States, Idaho
Saint Luke's Mountain States Tumor Institute Recruiting
Boise, Idaho, United States, 83712
Contact: Paul Montgomery, MD    208-381-2711      
Kootenai Medical Center Recruiting
Couer D'Alene, Idaho, United States, 83814
Contact: Benjamin Marchello, MD    406-238-6290      
Saint Luke's Mountain States Tumor Institute - Fruitland Recruiting
Fruitland, Idaho, United States, 83619
Contact: Keith Lanier, MD    503-216-6300      
Saint Luke's Mountain States Tumor Institute - Meridian Recruiting
Meridian, Idaho, United States, 83642
Contact: Keith Lanier, MD    503-216-6300      
Saint Luke's Mountain States Tumor Institute - Nampa Recruiting
Nampa, Idaho, United States, 83686
Contact: Keith Lanier, MD    503-216-6300      
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin Marchello, MD    406-238-6290      
Kootenai Cancer Clinic Recruiting
Sandpoint, Idaho, United States, 83864
Contact: Benjamin Marchello, MD    406-238-6290      
Saint Luke's Mountain States Tumor Institute-Twin Falls Recruiting
Twin Falls, Idaho, United States, 83301
Contact: Keith Lanier, MD    503-216-6300      
United States, Illinois
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Priya Kumthekar, MD    312-908-5035      
Hematology Oncology Associates-Highland Park Recruiting
Highland Park, Illinois, United States, 60035
Contact: Priya Kumthekar, MD    312-908-5035      
NorthShore Hematology Oncology-Libertyville Recruiting
Libertyville, Illinois, United States, 60048
Contact: Priya Kumthekar, MD    312-908-5035      
Illinois Cancer Specialists-Niles Recruiting
Niles, Illinois, United States, 60714
Contact: Priya Kumthekar, MD    312-908-5035      
Advocate Lutheran General Hospital Recruiting
Park Ridge, Illinois, United States, 60068
Contact: Heather Leeper, MD    847-723-4500      
Hematology Oncology Associates of Illinois-Skokie Recruiting
Skokie, Illinois, United States, 60076
Contact: Priya Kumthekar, MD    312-908-5035      
United States, Indiana
Memorial Regional Cancer Center-Day Road Recruiting
Mishawaka, Indiana, United States, 46544
Contact: Thomas Reid, MD    574-647-1100      
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Thomas Reid, MD    574-647-1100      
United States, Iowa
Mary Greeley Medical Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph Merchant, MD    515-956-2759      
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph Merchant, MD    515-956-2759      
McFarland Clinic PC-Boone Recruiting
Boone, Iowa, United States, 50036
Contact: Joseph Merchant, MD    515-956-2759      
Medical Oncology and Hematology Associates-West Des Moines Recruiting
Clive, Iowa, United States, 50325
Contact: Robert Behrens, MD    515-244-7586      
Mercy Cancer Center - West Lakes Recruiting
Clive, Iowa, United States, 50325
Contact: Mehmet Copur, MD    308-398-5450      
Alegent Health Mercy Hospital Recruiting
Council Bluffs, Iowa, United States, 51503
Contact: Mehmet Copur, MD    308-398-5450      
Greater Regional Medical Center Recruiting
Creston, Iowa, United States, 50801
Contact: Mehmet Copur, MD    308-398-5450      
Iowa Lutheran Hospital Recruiting
Des Moines, Iowa, United States, 50316
Contact: Robert Behrens, MD    515-244-7586      
Iowa-Wide Oncology Research Coalition NCORP Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert Behrens, MD    515-244-7586      
Medical Oncology and Hematology Associates-Des Moines Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert Behrens, MD    515-244-7586      
Medical Oncology and Hematology Associates-Laurel Recruiting
Des Moines, Iowa, United States, 50314
Contact: Mehmet Copur, MD    308-398-5450      
Mercy Medical Center-Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Mehmet Copur, MD    308-398-5450      
Iowa Methodist Medical Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert Behrens, MD    515-244-7586      
McFarland Clinic PC-Trinity Cancer Center Recruiting
Fort Dodge, Iowa, United States, 50501
Contact: Joseph Merchant, MD    515-956-2759      
McFarland Clinic PC-Jefferson Recruiting
Jefferson, Iowa, United States, 50129
Contact: Joseph Merchant, MD    515-956-2759      
McFarland Clinic PC-Marshalltown Recruiting
Marshalltown, Iowa, United States, 50158
Contact: Joseph Merchant, MD    515-956-2759      
Mercy Medical Center-West Lakes Recruiting
West Des Moines, Iowa, United States, 50266
Contact: Mehmet Copur, MD    308-398-5450      
Methodist West Hospital Recruiting
West Des Moines, Iowa, United States, 50266
Contact: Robert Behrens, MD    515-244-7586      
United States, Kentucky
Flaget Memorial Hospital Recruiting
Bardstown, Kentucky, United States, 40004
Contact: Mehmet Copur, MD    308-398-5450      
Commonwealth Cancer Center-Corbin Recruiting
Corbin, Kentucky, United States, 40701
Contact: Mehmet Copur, MD    308-398-5450      
Saint Joseph Radiation Oncology Resource Center Recruiting
Lexington, Kentucky, United States, 40504
Contact: Mehmet Copur, MD    308-398-5450      
Saint Joseph Hospital East Recruiting
Lexington, Kentucky, United States, 40509
Contact: Mehmet Copur, MD    308-398-5450      
Norton Hospital Pavilion and Medical Campus Recruiting
Louisville, Kentucky, United States, 40202
Contact: Aaron Spalding, MD    502-629-2500      
Jewish Hospital Recruiting
Louisville, Kentucky, United States, 40202
Contact: Mehmet Copur, MD    308-398-5450      
Saints Mary and Elizabeth Hospital Recruiting
Louisville, Kentucky, United States, 40215
Contact: Mehmet Copur, MD    308-398-5450      
Jewish Hospital Medical Center Northeast Recruiting
Louisville, Kentucky, United States, 40245
Contact: Mehmet Copur, MD    308-398-5450      
Jewish Hospital Medical Center South Recruiting
Shepherdsville, Kentucky, United States, 40165
Contact: Mehmet Copur, MD    308-398-5450      
United States, Maine
Maine Medical Center - Bramhall Campus Recruiting
Portland, Maine, United States, 04102
Contact: Ian Bristol, MD    207-396-8377      
Maine Medical Center- Scarborough Campus Recruiting
Scarborough, Maine, United States, 04074
Contact: Ian Bristol, MD    207-396-8377      
United States, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center Recruiting
Baltimore, Maryland, United States, 21287
Contact: Matthias Holdhoff, MD    443-287-0337      
United States, Michigan
Henry Ford Hospital Recruiting
Detroit, Michigan, United States, 48202
Contact: Robert Chapman, MD    313-916-1784      
Botsford Hospital Recruiting
Farmington, Michigan, United States, 48336
Contact: Peter Chen, MD    248-551-7038      
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Nagpal Sunil, MD    269-382-2500      
Michigan Cancer Specialists Recruiting
Roseville, Michigan, United States, 48066
Contact: Peter Chen, MD    248-551-7038      
William Beaumont Hospital-Royal Oak Recruiting
Royal Oak, Michigan, United States, 48073
Contact: Peter Chen, MD    248-551-7038      
Comprehensive Medical Center PLLC Recruiting
Royal Oak, Michigan, United States, 48073
Contact: Peter Chen, MD    248-551-7038      
Hematology Oncology Consultants PC-Royal Oak Recruiting
Royal Oak, Michigan, United States, 48073
Contact: Peter Chen, MD    248-551-7038      
Cancer Care Associates PC Recruiting
Royal Oak, Michigan, United States, 48073
Contact: Peter Chen, MD    248-551-7038      
Mitchell Folbe MD PC Recruiting
Sterling Heights, Michigan, United States, 48314
Contact: Peter Chen, MD    248-551-7038      
William Beaumont Hospital - Troy Recruiting
Troy, Michigan, United States, 48098
Contact: Peter Chen, MD    248-551-7038      
Michigan Institute of Urology-Town Center Recruiting
Troy, Michigan, United States, 48084
Contact: Peter Chen, MD    248-551-7038      
Claudia BR Herke MD PC Recruiting
Troy, Michigan, United States, 48085
Contact: Peter Chen, MD    248-551-7038      
Hematology Oncology Consultants PC-Troy Recruiting
Troy, Michigan, United States, 48098
Contact: Peter Chen, MD    248-551-7038      
United States, Minnesota
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Patrick Flynn, MD    952-993-1517      
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Patrick Flynn, MD    952-993-1517      
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Patrick Flynn, MD    952-993-1517      
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Patrick Flynn, MD    952-993-1517      
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick Flynn, MD    952-993-1517      
Saint John's Hospital-Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick Flynn, MD    952-993-1517      
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Patrick Flynn, MD    952-993-1517      
Health Partners Inc Recruiting
Minneapolis, Minnesota, United States, 55454
Contact: Patrick Flynn, MD    952-993-1517      
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Patrick Flynn, MD    952-993-1517      
New Ulm Medical Center Recruiting
New Ulm, Minnesota, United States, 56073
Contact: Patrick Flynn, MD    952-993-1517      
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Patrick Flynn, MD    952-993-1517      
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Kurt Jaeckle, MD    904-953-7102      
Park Nicollet Clinic-Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick Flynn, MD    952-993-1517      
Metro Minnesota Community Oncology Research Consortium Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick Flynn, MD    952-993-1517      
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Patrick Flynn, MD    952-993-1517      
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Patrick Flynn, MD    952-993-1517      
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Patrick Flynn, MD    952-993-1517      
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Patrick Flynn, MD    952-993-1517      
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Patrick Flynn, MD    952-993-1517      
Rice Memorial Hospital Recruiting
Wilmar, Minnesota, United States, 56201
Contact: Patrick Flynn, MD    952-993-1517      
Minnesota Oncology and Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Patrick Flynn, MD    952-993-1517      
United States, Missouri
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Jian Campian, MD    314-747-4241      
United States, Montana
Saint Vincent Healthcare Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin Marchello, MD    406-238-6290      
Montana Cancer Consortium NCORP Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin Marchello, MD    406-238-6290      
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59107
Contact: Benjamin Marchello, MD    406-238-6290      
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin Marchello, MD    406-238-6290      
Saint James Community Hospital and Cancer Treatment Center Recruiting
Butte, Montana, United States, 59701
Contact: Benjamin Marchello, MD    406-238-6290      
Benefis Healthcare-Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin Marchello, MD    406-238-6290      
Saint Peter's Community Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin Marchello, MD    406-238-6290      
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin Marchello, MD    406-238-6290      
Community Medical Hospital Recruiting
Missoula, Montana, United States, 59801
Contact: Benjamin Marchello, MD    406-238-6290      
Saint Patrick Hospital - Community Hospital Recruiting
Missoula, Montana, United States, 59802
Contact: Benjamin Marchello, MD    406-238-6290      
United States, Nebraska
CHI Health Saint Francis Recruiting
Grand Island, Nebraska, United States, 68803
Contact: Mehmet Copur, MD    308-398-5450      
CHI Health Good Samaritan Recruiting
Kearney, Nebraska, United States, 68847
Contact: Mehmet Copur, MD    308-398-5450      
Nebraska Hematology and Oncology Recruiting
Lincoln, Nebraska, United States, 68506
Contact: Gamini Soori, MD    402-393-3110      
Nebraska Cancer Research Center Recruiting
Lincoln, Nebraska, United States, 68510
Contact: Gamini Soori, MD    402-393-3110      
Saint Elizabeth Regional Medical Center Recruiting
Lincoln, Nebraska, United States, 68510
Contact: Mehmet Copur, MD    308-398-5450      
Faith Regional Medical Offices West Recruiting
Norfolk, Nebraska, United States, 68701
Contact: Gamini Soori, MD    402-393-3110      
Great Plains Regional Medical Center Recruiting
North Platte, Nebraska, United States, 69101
Contact: Gamini Soori, MD    402-393-3110      
University of Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
Contact: Nicole Shonka, MD    402-559-5520      
Oncology Hematology West PC Recruiting
Omaha, Nebraska, United States, 68114
Contact: Gamini Soori, MD    402-393-3110      
Alegent Health Immanuel Medical Center Recruiting
Omaha, Nebraska, United States, 68122
Contact: Mehmet Copur, MD    308-398-5450      
Hematology and Oncology Consultants PC Recruiting
Omaha, Nebraska, United States, 68122
Contact: Mehmet Copur, MD    308-398-5450      
Alegent Health Bergan Mercy Medical Center Recruiting
Omaha, Nebraska, United States, 68124
Contact: Gamini Soori, MD    402-393-3110      
Missouri Valley Cancer Consortium Recruiting
Omaha, Nebraska, United States, 68106
Contact: Gamini Soori, MD    402-393-3110      
Alegent Health Lakeside Hospital Recruiting
Omaha, Nebraska, United States, 68130
Contact: Gamini Soori, MD    402-393-3110      
Creighton University Medical Center Recruiting
Omaha, Nebraska, United States, 68131
Contact: Mehmet Copur, MD    308-398-5450      
Oncology Hematology West Recruiting
Omaha, Nebraska, United States, 68124
Contact: Gamini Soori, MD    402-393-3110      
Midlands Community Hospital Recruiting
Papillion, Nebraska, United States, 68046
Contact: Mehmet Copur, MD    308-398-5450      
United States, Nevada
Cancer and Blood Specialists-Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: John Ellerton, MD    702-822-2000      
Comprehensive Cancer Centers of Nevada-Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: John Ellerton, MD    702-822-2000      
Las Vegas Cancer Center-Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: John Ellerton, MD    702-822-2000      
21st Century Oncology-Henderson Recruiting
Henderson, Nevada, United States, 89074
Contact: John Ellerton, MD    702-822-2000      
Comprehensive Cancer Centers of Nevada-Southeast Henderson Recruiting
Henderson, Nevada, United States, 89074
Contact: John Ellerton, MD    702-822-2000      
Cancer and Blood Specialists-Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John Ellerton, MD    702-822-2000      
Nevada Cancer Research Foundation NCORP Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John Ellerton, MD    702-822-2000      
Radiation Oncology Centers of Nevada Central Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John Ellerton, MD    702-822-2000      
21st Century Oncology-Fort Apache Recruiting
Las Vegas, Nevada, United States, 89109
Contact: John Ellerton, MD    702-822-2000      
21st Century Oncology Recruiting
Las Vegas, Nevada, United States, 89109
Contact: John Ellerton, MD    702-822-2000      
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Recruiting
Las Vegas, Nevada, United States, 89109
Contact: John Ellerton, MD    702-822-2000      
HealthCare Partners Medical Group Oncology/Hematology-San Martin Recruiting
Las Vegas, Nevada, United States, 89113
Contact: John Ellerton, MD    702-822-2000      
Radiation Oncology Centers of Nevada Southeast Recruiting
Las Vegas, Nevada, United States, 89119
Contact: John Ellerton, MD    702-822-2000      
Cancer Therapy and Integrative Medicine Recruiting
Las Vegas, Nevada, United States, 89121
Contact: John Ellerton, MD    702-822-2000      
21st Century Oncology-Vegas Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John Ellerton, MD    702-822-2000      
Comprehensive Cancer Centers of Nevada-Central Valley Recruiting
Las Vegas, Nevada, United States, 89169
Contact: John Ellerton, MD    702-822-2000      
Comprehensive Cancer Centers of Nevada-Northwest Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John Ellerton, MD    702-822-2000      
HealthCare Partners Medical Group Oncology/Hematology-Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: John Ellerton, MD    702-822-2000      
Comprehensive Cancer Centers of Nevada-Summerlin Recruiting
Las Vegas, Nevada, United States, 89144
Contact: John Ellerton, MD    702-822-2000      
Cancer and Blood Specialists-Fort Apache Recruiting
Las Vegas, Nevada, United States, 89148
Contact: John Ellerton, MD    702-822-2000      
Comprehensive Cancer Centers of Nevada Recruiting
Las Vegas, Nevada, United States, 89148
Contact: John Ellerton, MD    702-822-2000      
Las Vegas Cancer Center-Medical Center Recruiting
Las Vegas, Nevada, United States, 89148
Contact: John Ellerton, MD    702-822-2000      
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Recruiting
Las Vegas, Nevada, United States, 89149
Contact: John Ellerton, MD    702-822-2000      
Cancer and Blood Specialists-Shadow Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John Ellerton, MD    702-822-2000      
United States, New Hampshire
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Lara Kunschner-Ronan, MD    603-650-6312      
United States, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital Recruiting
New Brunswick, New Jersey, United States, 08903
Contact: Sabin Motwani, MD    973-972-5053      
Rutgers Cancer Institute of New Jersey Recruiting
New Brunswick, New Jersey, United States, 08903
Contact: Sabin Motwani, MD    973-972-5053      
United States, New Mexico
University of New Mexico Cancer Center Recruiting
Albuquerque, New Mexico, United States, 87102
Contact: Fa-Chyi Lee, MD    505-925-0407      
United States, New York
Highland Hospital Recruiting
Rochester, New York, United States, 14620
Contact: Yuhchyau Chen, MD    585-276-4543      
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Yuhchyau Chen, MD    585-276-4543      
United States, North Dakota
Altru Cancer Center Recruiting
Grand Forks, North Dakota, United States, 58201
Contact: Grant Seeger, MD    701-780-5860      
United States, Ohio
Cleveland Clinic Cancer Center Beachwood Recruiting
Beachwood, Ohio, United States, 44122
Contact: Samuel Chao, MD    216-445-8776      
Adena Regional Medical Center Recruiting
Chillicothe, Ohio, United States, 54601
Contact: John Kuebler, MD    614-488-2118      
Good Samaritan Hospital - Cincinnati Recruiting
Cincinnati, Ohio, United States, 45220
Contact: Mehmet Copur, MD    308-398-5450      
Bethesda North Hospital Recruiting
Cincinnati, Ohio, United States, 45242
Contact: Mehmet Copur, MD    308-398-5450      
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Joseph Gibbons, MD    216-844-4735      
Cleveland Clinic Cancer Center/Fairview Hospital Recruiting
Cleveland, Ohio, United States, 44111
Contact: Samuel Chao, MD    216-445-8776      
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Samuel Chao, MD    216-445-8776      
Grant Medical Center Recruiting
Columbus, Ohio, United States, 43215
Contact: John Kuebler, MD    614-566-3275      
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: John Kuebler, MD    614-488-2118      
Columbus NCI Community Oncology Research Program Recruiting
Columbus, Ohio, United States, 43215
Contact: John Kuebler, MD    614-488-2118      
Doctors Hospital Recruiting
Columbus, Ohio, United States, 43228
Contact: John Kuebler, MD    614-488-2118      
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: John Kuebler, MD    614-488-2118      
Mount Carmel Health Center West Recruiting
Columbus, Ohio, United States, 43222
Contact: John Kuebler, MD    614-488-2118      
Columbus Oncology and Hematology Associates Inc Recruiting
Columbus, Ohio, United States, 43214
Contact: John Kuebler, MD    614-488-2118      
Delaware Health Center-Grady Cancer Center Recruiting
Delaware, Ohio, United States, 43015
Contact: John Kuebler, MD    614-488-2118      
Delaware Radiation Oncology Recruiting
Delaware, Ohio, United States, 43015
Contact: John Kuebler, MD    614-488-2118      
Grady Memorial Hospital Recruiting
Delaware, Ohio, United States, 43015
Contact: John Kuebler, MD    614-488-2118      
Cleveland Clinic Cancer Center Independence Recruiting
Independence, Ohio, United States, 44131
Contact: Samuel Chao, MD    216-445-8776      
Fairfield Medical Center Recruiting
Lancaster, Ohio, United States, 43130
Contact: John Kuebler, MD    614-488-2118      
Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: John Kuebler, MD    614-488-2118      
Hillcrest Hospital Cancer Center Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Samuel Chao, MD    216-445-8776      
Knox Community Hospital Recruiting
Mount Vernon, Ohio, United States, 43050
Contact: John Kuebler, MD    614-488-2118      
Licking Memorial Hospital Recruiting
Newark, Ohio, United States, 43055
Contact: John Kuebler, MD    614-488-2118      
Newark Radiation Oncology Recruiting
Newark, Ohio, United States, 43055
Contact: John Kuebler, MD    614-488-2118      
Saint Ann's Hospital Recruiting
Westerville, Ohio, United States, 43081
Contact: John Kuebler, MD    614-488-2118      
Cleveland Clinic Wooster Specialty Center Recruiting
Wooster, Ohio, United States, 44691
Contact: Samuel Chao, MD    216-445-8776      
Genesis Healthcare System Cancer Care Center Recruiting
Zanesville, Ohio, United States, 43701
Contact: John Kuebler, MD    614-488-2118      
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Terence Herman, MD    405-271-3016      
United States, Oregon
Saint Charles Health System Recruiting
Bend, Oregon, United States, 97701
Contact: Keith Lanier, MD    303-777-2663      
Providence Oncology and Hematology Care Southeast Recruiting
Clackamas, Oregon, United States, 97015
Contact: Keith Lanier, MD    503-216-6300      
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Keith Lanier, MD    503-216-6300      
Bay Area Hospital Recruiting
Coos Bay, Oregon, United States, 97420
Contact: Keith Lanier, MD    503-216-6300      
Providence Newberg Medical Center Recruiting
Newberg, Oregon, United States, 97132
Contact: Keith Lanier, MD    503-216-6300      
Providence Willamette Falls Medical Center Recruiting
Oregon City, Oregon, United States, 97045
Contact: Keith Lanier, MD    503-216-6300      
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Keith Lanier, MD    503-216-6300      
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Keith Lanier, MD    503-216-6300      
United States, Pennsylvania
Abington Memorial Hospital Recruiting
Abington, Pennsylvania, United States, 19001
Contact: Willard Andrews, MD    215-481-2400      
Saint Luke's University Hospital-Bethlehem Campus Recruiting
Bethlehem, Pennsylvania, United States, 18015
Contact: Hugh Moulding, MD    484-526-6000      
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822
Contact: Scott Turner, MD    319-363-2690      
Geisinger Medical Center-Cancer Center Hazleton Recruiting
Hazleton, Pennsylvania, United States, 18201
Contact: Scott Turner, MD    319-363-2690      
Geisinger Medical Oncology-Lewisburg Recruiting
Lewisburg, Pennsylvania, United States, 17837
Contact: Scott Turner, MD    319-363-2690      
Lewistown Hospital Recruiting
Lewistown, Pennsylvania, United States, 17044
Contact: Scott Turner, MD    319-363-2690      
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Jon Glass, MD    215-503-7005      
University of Pittsburgh Cancer Institute (UPCI) Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: David Clump, MD    412-623-6270      
Geisinger Wyoming Valley/Henry Cancer Center Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Scott Turner, MD    319-363-2690      
United States, South Carolina
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: Michael Lindhorst, MD    843-792-4271      
Greenville Health System Cancer Institute-Easley Recruiting
Easley, South Carolina, United States, 29640
Contact: David Grisell, MD    864-241-6251      
Greenville Health System Cancer Institute-Andrews Recruiting
Greenville, South Carolina, United States, 29601
Contact: David Grisell, MD    864-241-6251      
Greenville Health System Cancer Institute-Butternut Recruiting
Greenville, South Carolina, United States, 29605
Contact: David Griselle, MD    864-241-6251      
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: David Grisell, MD    864-241-6251      
Greenville Memorial Hospital Recruiting
Greenville, South Carolina, United States, 29605
Contact: David Grisell, MD    864-241-6251      
Greenville Health System Cancer Institute-Eastside Recruiting
Greenville, South Carolina, United States, 29615
Contact: David Grisell, MD    864-241-6251      
Greenville Health System Cancer Institute-Greer Recruiting
Greer, South Carolina, United States, 29650
Contact: David Grisell, MD    864-241-6251      
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: David Grisell, MD    864-241-6251      
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: David Grisell, MD    864-241-6251      
United States, South Dakota
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Joshua Lukenbill, MD    605-755-2301      
United States, Tennessee
Memorial Hospital Recruiting
Chattanooga, Tennessee, United States, 37404
Contact: Mehmet Copur, MD    308-398-5450      
Pulmonary Medicine Center of Chattanooga-Hixson Recruiting
Hixson, Tennessee, United States, 37343
Contact: Mehmet Copur, MD    308-398-5450      
Vanderbilt University-Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Paul Moots, MD    615-936-0216      
Memorial GYN Plus Recruiting
Ooltewah, Tennessee, United States, 37363
Contact: Mehmet Copur, MD    308-398-5450      
United States, Texas
University of Texas Medical Branch Recruiting
Galveston, Texas, United States, 77555
Contact: Martin Colman, MD    409-772-6723      
UTMB Cancer Center at Victory Lakes Recruiting
League City, Texas, United States, 77573
Contact: Martin Colman, MD    409-772-6723      
United States, Utah
American Fork Hospital / Huntsman Intermountain Cancer Center Recruiting
American Fork, Utah, United States, 84003
Contact: Jeffrey Lee, MD    801-507-3888      
Sandra L Maxwell Cancer Center Recruiting
Cedar City, Utah, United States, 84720
Contact: Jeffrey Lee, MD    801-507-3888      
Logan Regional Hospital Recruiting
Logan, Utah, United States, 84321
Contact: Jeffrey Lee, MD    801-507-3888      
Intermountain Medical Center Recruiting
Murray, Utah, United States, 84157
Contact: Jeffrey Lee, MD    801-507-3888      
McKay-Dee Hospital Center Recruiting
Ogden, Utah, United States, 84403
Contact: Jeffrey Lee, MD    801-507-3888      
Utah Valley Regional Medical Center Recruiting
Provo, Utah, United States, 84604
Contact: Jeffrey Lee, MD    801-507-3888      
Dixie Medical Center Regional Cancer Center Recruiting
Saint George, Utah, United States, 84770
Contact: Jeffrey Lee, MD    801-507-3888      
Utah Cancer Specialists-Salt Lake City Recruiting
Salt Lake City, Utah, United States, 84106
Contact: Jeffrey Lee, MD    801-507-3888      
LDS Hospital Recruiting
Salt Lake City, Utah, United States, 84143
Contact: Jeffrey Lee, MD    801-507-3888      
United States, Virginia
Virginia Commonwealth University/Massey Cancer Center Recruiting
Richmond, Virginia, United States, 23298
Contact: Mark Malkin, MD    804-828-8340      
United States, Washington
Providence Regional Cancer System-Aberdeen Recruiting
Aberdeen, Washington, United States, 98520
Contact: Keith Lanier, MD    503-216-6300      
Cancer Care Center at Island Hospital Recruiting
Anacortes, Washington, United States, 98221
Contact: Keith Lanier, MD    503-216-6300      
PeaceHealth Saint Joseph Medical Center Recruiting
Bellingham, Washington, United States, 98225
Contact: Keith Lanier, MD    503-216-6300      
Harrison HealthPartners Hematology and Oncology-Bremerton Recruiting
Bremerton, Washington, United States, 98310
Contact: Mehmet Copur, MD    308-398-5450      
Harrison Medical Center Recruiting
Bremerton, Washington, United States, 98310
Contact: Mehmet Copur, MD    308-398-5450      
Highline Medical Center-Main Campus Recruiting
Burien, Washington, United States, 98166
Contact: Mehmet Copur, MD    308-398-5450      
Providence Regional Cancer System-Centralia Recruiting
Centralia, Washington, United States, 98531
Contact: Keith Lanier, MD    503-216-6300      
Saint Elizabeth Hospital Recruiting
Enumclaw, Washington, United States, 98022
Contact: Mehmet Copur, MD    308-398-5450      
Providence Regional Cancer Partnership Recruiting
Everett, Washington, United States, 98201
Contact: Keith Lanier, MD    503-216-6300      
Saint Francis Hospital Recruiting
Federal Way, Washington, United States, 98003
Contact: Mehmet Copur, MD    308-398-5450      
EvergreenHealth Medical Center Recruiting
Kirkland, Washington, United States, 99218
Contact: George Laramore, MD    206-598-4118      
Providence Regional Cancer System-Lacey Recruiting
Lacey, Washington, United States, 98503
Contact: Keith Lanier, MD    503-216-6300      
Saint Clare Hospital Recruiting
Lakewood, Washington, United States, 98499
Contact: Mehmet Copur, MD    308-398-5450      
Saint John Medical Center Recruiting
Longview, Washington, United States, 98632
Contact: Keith Lanier, MD    503-216-6300      
Harrison HealthPartners Hematology and Oncology-Poulsbo Recruiting
Poulsbo, Washington, United States, 98370
Contact: Mehmet Copur, MD    308-398-5450      
Group Health Cooperative-Seattle Recruiting
Seattle, Washington, United States, 98112
Contact: Keith Lanier, MD    503-216-6300      
Virginia Mason Medical Center Recruiting
Seattle, Washington, United States, 98101
Contact: Craig Nichols, MD    206-223-6193      
Pacific Gynecology Specialists Recruiting
Seattle, Washington, United States, 98104
Contact: Keith Lanier, MD    503-216-6300      
Fred Hutchinson Cancer Research Center Recruiting
Seattle, Washington, United States, 98109
Contact: George Laramore, MD    206-598-4118      
Minor and James Medical PLLC Recruiting
Seattle, Washington, United States, 98104
Contact: Keith Lanier, MD    503-216-6300      
Providence Regional Cancer System-Shelton Recruiting
Shelton, Washington, United States, 98584
Contact: Keith Lanier, MD    503-216-6300      
Rockwood Cancer Treatment Center-DHEC-Downtown Recruiting
Spokane, Washington, United States, 99204
Contact: Keith Lanier, MD    503-216-6300      
Evergreen Hematology and Oncology PS Recruiting
Spokane, Washington, United States, 99218
Contact: Keith Lanier, MD    503-216-6300      
Rockwood Clinic Cancer Treatment Center-Valley Recruiting
Spokane Valley, Washington, United States, 99216
Contact: Keith Lanier, MD    503-216-6300      
Franciscan Research Center-Northwest Medical Plaza Recruiting
Tacoma, Washington, United States, 98405
Contact: Mehmet Copur, MD    308-398-5450      
Northwest Medical Specialties PLLC Recruiting
Tacoma, Washington, United States, 98405
Contact: Mehmet Copur, MD    308-398-5450      
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Keith Lanier, MD    503-216-6300      
Providence Saint Mary Regional Cancer Center Recruiting
Walla Walla, Washington, United States, 99362
Contact: Keith Lanier, MD    503-216-6300      
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Recruiting
Yakima, Washington, United States, 98902
Contact: Keith Lanier, MD    503-216-6300      
Providence Regional Cancer System-Yelm Recruiting
Yelm, Washington, United States, 98597
Contact: Keith Lanier, MD    503-216-6300      
United States, Wisconsin
Gundersen Lutheran Medical Center Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Collin Driscoll, MD    608-782-7300      
Aurora Saint Luke's Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Ali Choucair, MD    414-384-5111      
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Joseph Bovi, MD    414-805-4474      
D N Greenwald Center Recruiting
Mukwonago, Wisconsin, United States, 53149
Contact: Timothy Wassenaar, MD    262-928-2570      
Oconomowoc Memorial Hospital-ProHealth Care Inc Recruiting
Oconomowoc, Wisconsin, United States, 53066
Contact: Timothy Wassenaar, M.D.    262-928-2570      
Waukesha Memorial Hospital Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Timothy Wassenaar, MD    262-928-2570      
United States, Wyoming
Cheyenne Regional Medical Center-West Recruiting
Cheyenne, Wyoming, United States, 82001
Contact: Keren Sturtz, MD    303-777-2663      
Big Horn Basin Cancer Center Recruiting
Cody, Wyoming, United States, 82414
Contact: Benjamin Marchello, MD    406-238-6290      
Billings Clinic-Cody Recruiting
Cody, Wyoming, United States, 82414
Contact: Benjamin Marchello, MD    406-238-6290      
Sponsors and Collaborators
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)
European Organisation for Research and Treatment Center (EORTC)
NCIC Clinical Trials Group
Investigators
Study Chair: Kurt Jaeckle, MD Mayo Clinic
  More Information

Additional Information:
Responsible Party: Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier: NCT00887146     History of Changes
Other Study ID Numbers: Alliance N0577  NCI-2011-01915  EORTC-26081-22086  EudraCT-2008-007295-14  CDR0000640442 
Study First Received: April 22, 2009
Last Updated: March 17, 2016
Health Authority: United States: NCI Central Institutional Review Board

Keywords provided by Alliance for Clinical Trials in Oncology:
adult anaplastic astrocytoma
adult anaplastic oligodendroglioma
adult mixed glioma

Additional relevant MeSH terms:
Central Nervous System Neoplasms
Nervous System Neoplasms
Neoplasms
Neoplasms by Site
Nervous System Diseases
Dacarbazine
Procarbazine
Temozolomide
Alkylating Agents
Antineoplastic Agents
Antineoplastic Agents, Alkylating
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on May 26, 2016